Ahmed Medhat Mohyeldin

Title(s)Assistant Health Sciences Professor, Neurosurgery
Address1001 Health Sciences Road
Irvine CA 92697-3950
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    1. TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas. Clin Cancer Res. 2021 Aug 25. Gonzalez-Buendia E, Zhao J, Wang L, Mukherjee S, Zhang D, Arrieta VA, Feldstein E, Kane JR, Kang SJ, Lee-Chang C, Mahajan A, Chen L, Realubit R, Karan C, Magnuson L, Horbinski C, Marshall SA, Sarkaria JN, Mohyeldin A, Nakano I, Bansal M, James CD, Brat DJ, Ahmed A, Canoll P, Rabadan R, Shilatifard A, Sonabend AM. PMID: 34433651.
      View in: PubMed   Mentions:    Fields:    
    2. Microsurgical Anatomy of the Endoscopy-Assisted Retrosigmoid Intradural Suprameatal Approach to the Meckel's Cave. Oper Neurosurg (Hagerstown). 2021 07 15; 21(2):41-47. Xu Y, Hendricks BK, Nunez MA, Mohyeldin A, Fernandez-Miranda JC, Cohen-Gadol AA. PMID: 33930162.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Microsurgical anatomy of the lateral posterior choroidal artery: implications for intraventricular surgery involving the choroid plexus. J Neurosurg. 2021 Apr 09; 1-16. Xu Y, Mohyeldin A, Doniz-Gonzalez A, Vigo V, Pastor-Escartin F, Meng L, Cohen-Gadol AA, Fernandez-Miranda JC. PMID: 33836500.
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    4. Multi-compartment skull base orbital cavernous venous malformation: A rare presentation of a common orbital mass. Am J Ophthalmol Case Rep. 2021 Mar; 21:101020. Azad AD, Sears CM, Hwang PH, Mohyeldin A, Fernandez-Miranda J, Kossler AL. PMID: 33598587.
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    5. Endoscopic Endonasal Odontoidectomy with Nasopharyngeal Flap Reconstruction. J Neurol Surg B Skull Base. 2021 Feb; 82(Suppl 1):S12-S13. London NR, Mohyeldin A, Carrau RL, Prevedello DM. PMID: 33717803.
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    6. The transsylvian corridor through minimally invasive transcranial approaches: a comparative anatomical study. Neurosurg Rev. 2021 Oct; 44(5):2619-2627. Martinez-Perez R, Beer-Furlan A, Albonette-Felicio T, Hardesty DA, Mohyeldin A, Hara T, Carrau RL, Prevedello DM. PMID: 33210182.
      View in: PubMed   Mentions: 2     Fields:    
    7. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2. J Clin Invest. 2020 11 02; 130(11):6187. Wang J, Cheng P, Pavlyukov MS, Yu H, Zhang Z, Kim SH, Minata M, Mohyeldin A, Xie W, Chen D, Goidts V, Frett B, Hu W, Li H, Shin YJ, Lee Y, Nam DH, Kornblum HI, Wang M, Nakano I. PMID: 33044225.
      View in: PubMed   Mentions: 2     Fields:    
    8. Video Demonstration of a Tunneled Temporoparietal Fascia Flap: How I Do It. Laryngoscope. 2021 04; 131(4):E1088-E1093. London NR, Mohyeldin A, Silveira-Bertazzo G, Prevedello DM, Carrau RL. PMID: 32965673.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2. J Clin Invest. 2020 09 01; 130(9):5027. Wang J, Cheng P, Pavlyukov MS, Yu H, Zhang Z, Kim SH, Minata M, Mohyeldin A, Xie W, Chen D, Goidts V, Frett B, Hu W, Li H, Shin YJ, Lee Y, Nam DH, Kornblum HI, Wang M, Nakano I. PMID: 32870163.
      View in: PubMed   Mentions:    Fields:    
    10. Managing complications of endoscopic transsphenoidal surgery in pituitary adenomas. Expert Rev Endocrinol Metab. 2020 09; 15(5):311-319. Abhinav K, Tyler M, Dale OT, Mohyeldin A, Fernandez-Miranda JC, Katznelson L. PMID: 32744080.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Sinonasal undifferentiated carcinoma: Institutional trend toward induction chemotherapy followed by definitive chemoradiation. Head Neck. 2020 11; 42(11):3197-3205. London NR, Mohyeldin A, Daoud G, Gamez ME, Blakaj D, Bonomi M, Prevedello DM, Carrau RL. PMID: 32681692.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Contributing factors for delayed postoperative cerebrospinal fluid leaks and suggested treatment algorithm. Int Forum Allergy Rhinol. 2020 06; 10(6):779-784. London NR, Mohyeldin A, Montaser AS, Tanjararak K, Prevedello DM, Otto BA, Carrau RL. PMID: 32362077.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Targeting glioma-initiating cells via the tyrosine metabolic pathway. J Neurosurg. 2020 Feb 14; 134(3):721-732. Yamashita D, Bernstock JD, Elsayed G, Sadahiro H, Mohyeldin A, Chagoya G, Ilyas A, Mooney J, Estevez-Ordonez D, Yamaguchi S, Flanary VL, Hackney JR, Bhat KP, Kornblum HI, Zamboni N, Kim SH, Chiocca EA, Nakano I. PMID: 32059178.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    14. When a Meningioma Isn't: Endoscopic Endonasal Orbital Decompression and Biopsy of Skull Base Rosai-Dorfman Disease Treated Previously with Empiric Radiation Therapy. World Neurosurg. 2020 Mar; 135:141-145. Shah V, Mohyeldin A, London NR, Fritz J, Prevedello DM, Carrau RL, Hardesty DA. PMID: 31843730.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Acute presentation of spinal gouty arthritis: A case report and review of literature. Surg Neurol Int. 2019; 10:232. Akhter AS, Mohyeldin A, Grossbach AJ. PMID: 31893133.
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    16. Lower Extremity Paralysis After Radiofrequency Ablation of Vertebral Metastases. World Neurosurg. 2020 Jan; 133:178-184. Huntoon K, Eltobgy M, Mohyeldin A, Elder JB. PMID: 31606502.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    17. Pediatric craniopharyngioma. Childs Nerv Syst. 2019 11; 35(11):2133-2145. Drapeau A, Walz PC, Eide JG, Rugino AJ, Shaikhouni A, Mohyeldin A, Carrau RL, Prevedello DM. PMID: 31385085.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    18. Tumor. Oper Neurosurg (Hagerstown). 2019 Aug 01; 17(Suppl 2):S119-S152. Elder JB, Sherman JH, Prevedello DM, Szerlip NJ, Spratt DE, Shaikhouni A, Mohyeldin A, Perez-Roman RJ, Buttrick SS, Ali SC, Komotar RJ, Todeschini A, Shahein M, Revuelta JM, Hardesty D, Carrau RL, Zada G, Giannotta S, Dornbos D, Lonser RR. PMID: 31099848.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Pediatric pituitary adenomas. Childs Nerv Syst. 2019 11; 35(11):2107-2118. Walz PC, Drapeau A, Shaikhouni A, Eide J, Rugino AJ, Mohyeldin A, Carrau R, Prevedello D. PMID: 31302729.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation. Cell Rep. 2019 02 12; 26(7):1893-1905.e7. Minata M, Audia A, Shi J, Lu S, Bernstock J, Pavlyukov MS, Das A, Kim SH, Shin YJ, Lee Y, Koo H, Snigdha K, Waghmare I, Guo X, Mohyeldin A, Gallego-Perez D, Wang J, Chen D, Cheng P, Mukheef F, Contreras M, Reyes JF, Vaillant B, Sulman EP, Cheng SY, Markert JM, Tannous BA, Lu X, Kango-Singh M, Lee LJ, Nam DH, Nakano I, Bhat KP. PMID: 30759398.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    21. Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors. Cancer Cell. 2018 07 09; 34(1):119-135.e10. Pavlyukov MS, Yu H, Bastola S, Minata M, Shender VO, Lee Y, Zhang S, Wang J, Komarova S, Wang J, Yamaguchi S, Alsheikh HA, Shi J, Chen D, Mohyeldin A, Kim SH, Shin YJ, Anufrieva K, Evtushenko EG, Antipova NV, Arapidi GP, Govorun V, Pestov NB, Shakhparonov MI, Lee LJ, Nam DH, Nakano I. PMID: 29937354.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    22. Brachyury-YAP Regulatory Axis Drives Stemness and Growth in Cancer. Cell Rep. 2017 Oct 10; 21(2):495-507. Shah SR, David JM, Tippens ND, Mohyeldin A, Martinez-Gutierrez JC, Ganaha S, Schiapparelli P, Hamilton DH, Palena C, Levchenko A, Quiñones-Hinojosa A. PMID: 29020634.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    23. Stereotactic Biopsy Platforms with Intraoperative Imaging Guidance. Neurosurg Clin N Am. 2017 Oct; 28(4):465-475. Mohyeldin A, Elder JB. PMID: 28917276.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    24. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2. J Clin Invest. 2017 Aug 01; 127(8):3075-3089. Wang J, Cheng P, Pavlyukov MS, Yu H, Zhang Z, Kim SH, Minata M, Mohyeldin A, Xie W, Chen D, Goidts V, Frett B, Hu W, Li H, Shin YJ, Lee Y, Nam DH, Kornblum HI, Wang M, Nakano I. PMID: 28737508.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    25. FOXD1-ALDH1A3 Signaling Is a Determinant for the Self-Renewal and Tumorigenicity of Mesenchymal Glioma Stem Cells. Cancer Res. 2016 12 15; 76(24):7219-7230. Cheng P, Wang J, Waghmare I, Sartini S, Coviello V, Zhang Z, Kim SH, Mohyeldin A, Pavlyukov MS, Minata M, Valentim CL, Chhipa RR, Bhat KP, Dasgupta B, La Motta C, Kango-Singh M, Nakano I. PMID: 27569208.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    26. Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner. Cancer Cell. 2016 Feb 08; 29(2):201-13. Kim SH, Ezhilarasan R, Phillips E, Gallego-Perez D, Sparks A, Taylor D, Ladner K, Furuta T, Sabit H, Chhipa R, Cho JH, Mohyeldin A, Beck S, Kurozumi K, Kuroiwa T, Iwata R, Asai A, Kim J, Sulman EP, Cheng SY, Lee LJ, Nakada M, Guttridge D, DasGupta B, Goidts V, Bhat KP, Nakano I. PMID: 26859459.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    27. Real-time magnetic resonance imaging-guided frameless stereotactic brain biopsy: technical note. J Neurosurg. 2016 Apr; 124(4):1039-46. Mohyeldin A, Lonser RR, Elder JB. PMID: 26495951.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    28. MELK-a conserved kinase: functions, signaling, cancer, and controversy. Clin Transl Med. 2015; 4:11. Ganguly R, Mohyeldin A, Thiel J, Kornblum HI, Beullens M, Nakano I. PMID: 25852826.
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    29. Sinonasal morbidity following endoscopic endonasal skull base surgery. Clin Neurol Neurosurg. 2015 Mar; 130:162-7. Awad AJ, Mohyeldin A, El-Sayed IH, Aghi MK. PMID: 25621713.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    30. Nuances in the treatment of malignant tumors of the clival and petroclival region. Int Arch Otorhinolaryngol. 2014 Oct; 18(Suppl 2):S157-72. Mohyeldin A, Prevedello DM, Jamshidi AO, Ditzel Filho LF, Carrau RL. PMID: 25992140.
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    31. Medullary thyroid carcinoma presenting as a supraglottic mass. Ear Nose Throat J. 2014 Oct-Nov; 93(10-11):E40-2. White J, Mohyeldin A, Schwartz A, Bielamowicz S. PMID: 25397389.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    32. Novel tunneling system for implantation of percutaneous nerve field stimulator electrodes: a technical note. Neuromodulation. 2015 Jun; 18(4):313-6; discussion 316. Shaw A, Mohyeldin A, Zibly Z, Ikeda D, Deogaonkar M. PMID: 25123149.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    33. Role of cancer stem cells in spine tumors: review of current literature. Neurosurgery. 2012 Jul; 71(1):117-25. Hsu W, Mohyeldin A, Shah SR, Gokaslan ZL, Quinones-Hinojosa A. PMID: 22418583.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    34. Chordoma: current concepts, management, and future directions. Lancet Oncol. 2012 Feb; 13(2):e69-76. Walcott BP, Nahed BV, Mohyeldin A, Coumans JV, Kahle KT, Ferreira MJ. PMID: 22300861.
      View in: PubMed   Mentions: 163     Fields:    Translation:Humans
    35. Gene and viral therapy for glioblastoma: a review of clinical trials and future directions. Cancer J. 2012 Jan-Feb; 18(1):82-8. Mohyeldin A, Chiocca EA. PMID: 22290261.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    36. Generation of chordoma cell line JHC7 and the identification of Brachyury as a novel molecular target. J Neurosurg. 2011 Oct; 115(4):760-9. Hsu W, Mohyeldin A, Shah SR, ap Rhys CM, Johnson LF, Sedora-Roman NI, Kosztowski TA, Awad OA, McCarthy EF, Loeb DM, Wolinsky JP, Gokaslan ZL, Quiñones-Hinojosa A. PMID: 21699479.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    37. Harvey Cushing's early experience with pediatric gliomas. Childs Nerv Syst. 2011 May; 27(5):819-24. Sedora-Román NI, Pendleton C, Mohyeldin A, Quiñones-Hinojosa A. PMID: 21287180.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    38. Mesenchymal stem cells: new approaches for the treatment of neurological diseases. Curr Stem Cell Res Ther. 2010 Dec; 5(4):326-44. Momin EN, Mohyeldin A, Zaidi HA, Vela G, Quiñones-Hinojosa A. PMID: 20528757.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    39. Oxygen in stem cell biology: a critical component of the stem cell niche. Cell Stem Cell. 2010 Aug 06; 7(2):150-61. Mohyeldin A, Garzón-Muvdi T, Quiñones-Hinojosa A. PMID: 20682444.
      View in: PubMed   Mentions: 513     Fields:    Translation:HumansAnimalsCells
    40. Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons. Glia. 2010 Aug; 58(10):1168-76. Halim ND, Mcfate T, Mohyeldin A, Okagaki P, Korotchkina LG, Patel MS, Jeoung NH, Harris RA, Schell MJ, Verma A. PMID: 20544852.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    41. Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells. J Biol Chem. 2008 Aug 15; 283(33):22700-8. McFate T, Mohyeldin A, Lu H, Thakar J, Henriques J, Halim ND, Wu H, Schell MJ, Tsang TM, Teahan O, Zhou S, Califano JA, Jeoung NH, Harris RA, Verma A. PMID: 18541534.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansCells
    42. Survival and invasiveness of astrocytomas promoted by erythropoietin. J Neurosurg. 2007 Feb; 106(2):338-50. Mohyeldin A, Dalgard CL, Lu H, Mcfate T, Tait AS, Patel VC, Wong K, Rushing E, Roy S, Acs G, Verma A. PMID: 17410721.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    43. Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1. J Biol Chem. 2005 Dec 23; 280(51):41928-39. Lu H, Dalgard CL, Mohyeldin A, McFate T, Tait AS, Verma A. PMID: 16223732.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansCells
    44. Erythropoietin receptor function and expression in epithelial ovarian carcinoma. Gynecol Oncol. 2005 Dec; 99(3):571-7. McBroom JW, Acs G, Rose GS, Krivak TC, Mohyeldin A, Verma A. PMID: 16051335.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    45. Erythropoietin signaling promotes invasiveness of human head and neck squamous cell carcinoma. Neoplasia. 2005 May; 7(5):537-43. Mohyeldin A, Lu H, Dalgard C, Lai SY, Cohen N, Acs G, Verma A. PMID: 15967106.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    46. Endogenous 2-oxoacids differentially regulate expression of oxygen sensors. Biochem J. 2004 Jun 01; 380(Pt 2):419-24. Dalgard CL, Lu H, Mohyeldin A, Verma A. PMID: 14984367.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    47. Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progression. Am J Pathol. 2003 Jun; 162(6):1789-806. Acs G, Zhang PJ, McGrath CM, Acs P, McBroom J, Mohyeldin A, Liu S, Lu H, Verma A. PMID: 12759237.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
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