Ahmed Medhat Mohyeldin

Title(s)Assistant Health Sciences Professor, Neurosurgery
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(714) 456-6966
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    1. Impact of esthesioneuroblastoma treatment delays on overall patient survival. Laryngoscope. 2022 Apr 23. Tsutsumi K, Ahmed KH, Goshtasbi K, Torabi SJ, Mohyeldin A, Hsu FPK, Kuan EC. PMID: 35460271.
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    2. Microsurgical anatomy and the importance of the petrosal process of the sphenoid bone in endonasal surgery. J Neurosurg. 2022 Mar 11; 1-12. Doniz-Gonzalez A, Vigo V, Nunez MA, Xu Y, Mohyeldin A, Cohen-Gadol AA, Fernandez-Miranda JC. PMID: 35276642.
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    3. Microsurgical anatomy of the dorsal clinoidal space: implications for endoscopic endonasal parasellar surgery. J Neurosurg. 2022 Feb 04; 1-13. Xu Y, Nunez MA, Mohyeldin A, Vigo V, Mao Y, Cohen-Gadol AA, Fernandez-Miranda JC. PMID: 35120312.
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    4. Clinical outcomes, Kadish-INSICA staging and therapeutic targeting of somatostatin receptor 2 in olfactory neuroblastoma. Eur J Cancer. 2022 Feb; 162:221-236. Lechner M, Takahashi Y, Turri-Zanoni M, Liu J, Counsell N, Hermsen M, Kaur RP, Zhao T, Ramanathan M, Schartinger VH, Emanuel O, Helman S, Varghese J, Dudas J, Riechelmann H, Sprung S, Haybaeck J, Howard D, Engel NW, Stewart S, Brooks L, Pickles JC, Jacques TS, Fenton TR, Williams L, Vaz FM, O'Flynn P, Stimpson P, Wang S, Hannan SA, Unadkat S, Hughes J, Dwivedi R, Forde CT, Randhawa P, Gane S, Joseph J, Andrews PJ, Royle G, Franchi A, Maragliano R, Battocchio S, Bewicke-Copley H, Pipinikas C, Webster A, Thirlwell C, Ho D, Teschendorff A, Zhu T, Steele CD, Pillay N, Vanhaesebroeck B, Mohyeldin A, Fernandez-Miranda J, Park KW, Le QT, West RB, Saade R, Manes RP, Omay SB, Vining EM, Judson BL, Yarbrough WG, Sansovini M, Silvia N, Grassi I, Bongiovanni A, Capper D, Schüller U, Thavaraj S, Sandison A, Surda P, Hopkins C, Ferrari M, Mattavelli D, Rampinelli V, Facchetti F, Nicolai P, Bossi P, Henriquez OA, Magliocca K, Solares CA, Wise SK, Llorente JL, Patel ZM, Nayak JV, Hwang PH, Lacy PD, Woods R, O'Neill JP, Jay A, Carnell D, Forster MD, Ishii M, London NR, Bell DM, Gallia GL, Castelnuovo P, Severi S, Lund VJ, Hanna EY. PMID: 34980502.
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    5. Microvascular anatomy of the medial temporal region. J Neurosurg. 2021 Dec 24; 1-13. Xu Y, Mohyeldin A, Nunez MA, Doniz-Gonzalez A, Vigo V, Cohen-Gadol AA, Fernandez-Miranda JC. PMID: 34952521.
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    6. The association of frailty, age, and ASA classification with postoperative outcomes in minimally invasive pituitary surgery. Int Forum Allergy Rhinol. 2022 May; 12(5):780-783. Martin EC, Goshtasbi K, Birkenbeuel JL, Abiri A, Lehrich BM, Mohyeldin A, Hsu FPK, Kuan EC. PMID: 34821057.
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    7. TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas. Clin Cancer Res. 2021 10 15; 27(20):5669-5680. Gonzalez-Buendia E, Zhao J, Wang L, Mukherjee S, Zhang D, Arrieta VA, Feldstein E, Kane JR, Kang SJ, Lee-Chang C, Mahajan A, Chen L, Realubit R, Karan C, Magnuson L, Horbinski C, Marshall SA, Sarkaria JN, Mohyeldin A, Nakano I, Bansal M, James CD, Brat DJ, Ahmed A, Canoll P, Rabadan R, Shilatifard A, Sonabend AM. PMID: 34433651; PMCID: PMC8818263.
      View in: PubMed   Mentions:    Fields:    
    8. Microsurgical Anatomy of the Endoscopy-Assisted Retrosigmoid Intradural Suprameatal Approach to the Meckel's Cave. Oper Neurosurg (Hagerstown). 2021 07 15; 21(2):41-47. Xu Y, Hendricks BK, Nunez MA, Mohyeldin A, Fernandez-Miranda JC, Cohen-Gadol AA. PMID: 33930162.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Microsurgical anatomy of the lateral posterior choroidal artery: implications for intraventricular surgery involving the choroid plexus. J Neurosurg. 2021 Apr 09; 1-16. Xu Y, Mohyeldin A, Doniz-Gonzalez A, Vigo V, Pastor-Escartin F, Meng L, Cohen-Gadol AA, Fernandez-Miranda JC. PMID: 33836500.
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    10. Multi-compartment skull base orbital cavernous venous malformation: A rare presentation of a common orbital mass. Am J Ophthalmol Case Rep. 2021 Mar; 21:101020. Azad AD, Sears CM, Hwang PH, Mohyeldin A, Fernandez-Miranda J, Kossler AL. PMID: 33598587; PMCID: PMC7868709.
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    11. Endoscopic Endonasal Odontoidectomy with Nasopharyngeal Flap Reconstruction. J Neurol Surg B Skull Base. 2021 Feb; 82(Suppl 1):S12-S13. London NR, Mohyeldin A, Carrau RL, Prevedello DM. PMID: 33717803; PMCID: PMC7935724.
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    12. The transsylvian corridor through minimally invasive transcranial approaches: a comparative anatomical study. Neurosurg Rev. 2021 Oct; 44(5):2619-2627. Martinez-Perez R, Beer-Furlan A, Albonette-Felicio T, Hardesty DA, Mohyeldin A, Hara T, Carrau RL, Prevedello DM. PMID: 33210182.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    13. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2. J Clin Invest. 2020 11 02; 130(11):6187. Wang J, Cheng P, Pavlyukov MS, Yu H, Zhang Z, Kim SH, Minata M, Mohyeldin A, Xie W, Chen D, Goidts V, Frett B, Hu W, Li H, Shin YJ, Lee Y, Nam DH, Kornblum HI, Wang M, Nakano I. PMID: 33044225; PMCID: PMC7598038.
      View in: PubMed   Mentions: 2     Fields:    
    14. Video Demonstration of a Tunneled Temporoparietal Fascia Flap: How I Do It. Laryngoscope. 2021 04; 131(4):E1088-E1093. London NR, Mohyeldin A, Silveira-Bertazzo G, Prevedello DM, Carrau RL. PMID: 32965673.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2. J Clin Invest. 2020 09 01; 130(9):5027. Wang J, Cheng P, Pavlyukov MS, Yu H, Zhang Z, Kim SH, Minata M, Mohyeldin A, Xie W, Chen D, Goidts V, Frett B, Hu W, Li H, Shin YJ, Lee Y, Nam DH, Kornblum HI, Wang M, Nakano I. PMID: 32870163; PMCID: PMC7456217.
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    16. Managing complications of endoscopic transsphenoidal surgery in pituitary adenomas. Expert Rev Endocrinol Metab. 2020 09; 15(5):311-319. Abhinav K, Tyler M, Dale OT, Mohyeldin A, Fernandez-Miranda JC, Katznelson L. PMID: 32744080.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Sinonasal undifferentiated carcinoma: Institutional trend toward induction chemotherapy followed by definitive chemoradiation. Head Neck. 2020 11; 42(11):3197-3205. London NR, Mohyeldin A, Daoud G, Gamez ME, Blakaj D, Bonomi M, Prevedello DM, Carrau RL. PMID: 32681692.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Contributing factors for delayed postoperative cerebrospinal fluid leaks and suggested treatment algorithm. Int Forum Allergy Rhinol. 2020 06; 10(6):779-784. London NR, Mohyeldin A, Montaser AS, Tanjararak K, Prevedello DM, Otto BA, Carrau RL. PMID: 32362077.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Targeting glioma-initiating cells via the tyrosine metabolic pathway. J Neurosurg. 2020 Feb 14; 134(3):721-732. Yamashita D, Bernstock JD, Elsayed G, Sadahiro H, Mohyeldin A, Chagoya G, Ilyas A, Mooney J, Estevez-Ordonez D, Yamaguchi S, Flanary VL, Hackney JR, Bhat KP, Kornblum HI, Zamboni N, Kim SH, Chiocca EA, Nakano I. PMID: 32059178; PMCID: PMC8447888.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    20. When a Meningioma Isn't: Endoscopic Endonasal Orbital Decompression and Biopsy of Skull Base Rosai-Dorfman Disease Treated Previously with Empiric Radiation Therapy. World Neurosurg. 2020 Mar; 135:141-145. Shah V, Mohyeldin A, London NR, Fritz J, Prevedello DM, Carrau RL, Hardesty DA. PMID: 31843730.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    21. Acute presentation of spinal gouty arthritis: A case report and review of literature. Surg Neurol Int. 2019; 10:232. Akhter AS, Mohyeldin A, Grossbach AJ. PMID: 31893133; PMCID: PMC6911679.
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    22. Lower Extremity Paralysis After Radiofrequency Ablation of Vertebral Metastases. World Neurosurg. 2020 Jan; 133:178-184. Huntoon K, Eltobgy M, Mohyeldin A, Elder JB. PMID: 31606502.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. Pediatric craniopharyngioma. Childs Nerv Syst. 2019 11; 35(11):2133-2145. Drapeau A, Walz PC, Eide JG, Rugino AJ, Shaikhouni A, Mohyeldin A, Carrau RL, Prevedello DM. PMID: 31385085.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    24. Tumor. Oper Neurosurg (Hagerstown). 2019 Aug 01; 17(Suppl 2):S119-S152. Elder JB, Sherman JH, Prevedello DM, Szerlip NJ, Spratt DE, Shaikhouni A, Mohyeldin A, Perez-Roman RJ, Buttrick SS, Ali SC, Komotar RJ, Todeschini A, Shahein M, Revuelta JM, Hardesty D, Carrau RL, Zada G, Giannotta S, Dornbos D, Lonser RR. PMID: 31099848.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Pediatric pituitary adenomas. Childs Nerv Syst. 2019 11; 35(11):2107-2118. Walz PC, Drapeau A, Shaikhouni A, Eide J, Rugino AJ, Mohyeldin A, Carrau R, Prevedello D. PMID: 31302729.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    26. Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation. Cell Rep. 2019 02 12; 26(7):1893-1905.e7. Minata M, Audia A, Shi J, Lu S, Bernstock J, Pavlyukov MS, Das A, Kim SH, Shin YJ, Lee Y, Koo H, Snigdha K, Waghmare I, Guo X, Mohyeldin A, Gallego-Perez D, Wang J, Chen D, Cheng P, Mukheef F, Contreras M, Reyes JF, Vaillant B, Sulman EP, Cheng SY, Markert JM, Tannous BA, Lu X, Kango-Singh M, Lee LJ, Nam DH, Nakano I, Bhat KP. PMID: 30759398; PMCID: PMC6594377.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    27. Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors. Cancer Cell. 2018 07 09; 34(1):119-135.e10. Pavlyukov MS, Yu H, Bastola S, Minata M, Shender VO, Lee Y, Zhang S, Wang J, Komarova S, Wang J, Yamaguchi S, Alsheikh HA, Shi J, Chen D, Mohyeldin A, Kim SH, Shin YJ, Anufrieva K, Evtushenko EG, Antipova NV, Arapidi GP, Govorun V, Pestov NB, Shakhparonov MI, Lee LJ, Nam DH, Nakano I. PMID: 29937354; PMCID: PMC6048596.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    28. Brachyury-YAP Regulatory Axis Drives Stemness and Growth in Cancer. Cell Rep. 2017 Oct 10; 21(2):495-507. Shah SR, David JM, Tippens ND, Mohyeldin A, Martinez-Gutierrez JC, Ganaha S, Schiapparelli P, Hamilton DH, Palena C, Levchenko A, Quiñones-Hinojosa A. PMID: 29020634; PMCID: PMC5637538.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    29. Stereotactic Biopsy Platforms with Intraoperative Imaging Guidance. Neurosurg Clin N Am. 2017 Oct; 28(4):465-475. Mohyeldin A, Elder JB. PMID: 28917276.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    30. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2. J Clin Invest. 2017 Aug 01; 127(8):3075-3089. Wang J, Cheng P, Pavlyukov MS, Yu H, Zhang Z, Kim SH, Minata M, Mohyeldin A, Xie W, Chen D, Goidts V, Frett B, Hu W, Li H, Shin YJ, Lee Y, Nam DH, Kornblum HI, Wang M, Nakano I. PMID: 28737508; PMCID: PMC5531394.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    31. FOXD1-ALDH1A3 Signaling Is a Determinant for the Self-Renewal and Tumorigenicity of Mesenchymal Glioma Stem Cells. Cancer Res. 2016 12 15; 76(24):7219-7230. Cheng P, Wang J, Waghmare I, Sartini S, Coviello V, Zhang Z, Kim SH, Mohyeldin A, Pavlyukov MS, Minata M, Valentim CL, Chhipa RR, Bhat KP, Dasgupta B, La Motta C, Kango-Singh M, Nakano I. PMID: 27569208; PMCID: PMC5161538.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    32. Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner. Cancer Cell. 2016 Feb 08; 29(2):201-13. Kim SH, Ezhilarasan R, Phillips E, Gallego-Perez D, Sparks A, Taylor D, Ladner K, Furuta T, Sabit H, Chhipa R, Cho JH, Mohyeldin A, Beck S, Kurozumi K, Kuroiwa T, Iwata R, Asai A, Kim J, Sulman EP, Cheng SY, Lee LJ, Nakada M, Guttridge D, DasGupta B, Goidts V, Bhat KP, Nakano I. PMID: 26859459; PMCID: PMC4837946.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    33. Real-time magnetic resonance imaging-guided frameless stereotactic brain biopsy: technical note. J Neurosurg. 2016 Apr; 124(4):1039-46. Mohyeldin A, Lonser RR, Elder JB. PMID: 26495951.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    34. MELK-a conserved kinase: functions, signaling, cancer, and controversy. Clin Transl Med. 2015; 4:11. Ganguly R, Mohyeldin A, Thiel J, Kornblum HI, Beullens M, Nakano I. PMID: 25852826; PMCID: PMC4385133.
      View in: PubMed   Mentions: 47  
    35. Sinonasal morbidity following endoscopic endonasal skull base surgery. Clin Neurol Neurosurg. 2015 Mar; 130:162-7. Awad AJ, Mohyeldin A, El-Sayed IH, Aghi MK. PMID: 25621713.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    36. Medullary thyroid carcinoma presenting as a supraglottic mass. Ear Nose Throat J. 2014 Oct-Nov; 93(10-11):E40-2. White J, Mohyeldin A, Schwartz A, Bielamowicz S. PMID: 25397389.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    37. Nuances in the treatment of malignant tumors of the clival and petroclival region. Int Arch Otorhinolaryngol. 2014 Oct; 18(Suppl 2):S157-72. Mohyeldin A, Prevedello DM, Jamshidi AO, Ditzel Filho LF, Carrau RL. PMID: 25992140; PMCID: PMC4399585.
      View in: PubMed   Mentions: 4  
    38. Novel tunneling system for implantation of percutaneous nerve field stimulator electrodes: a technical note. Neuromodulation. 2015 Jun; 18(4):313-6; discussion 316. Shaw A, Mohyeldin A, Zibly Z, Ikeda D, Deogaonkar M. PMID: 25123149.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    39. Role of cancer stem cells in spine tumors: review of current literature. Neurosurgery. 2012 Jul; 71(1):117-25. Hsu W, Mohyeldin A, Shah SR, Gokaslan ZL, Quinones-Hinojosa A. PMID: 22418583.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    40. Chordoma: current concepts, management, and future directions. Lancet Oncol. 2012 Feb; 13(2):e69-76. Walcott BP, Nahed BV, Mohyeldin A, Coumans JV, Kahle KT, Ferreira MJ. PMID: 22300861.
      View in: PubMed   Mentions: 163     Fields:    Translation:Humans
    41. Gene and viral therapy for glioblastoma: a review of clinical trials and future directions. Cancer J. 2012 Jan-Feb; 18(1):82-8. Mohyeldin A, Chiocca EA. PMID: 22290261.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    42. Generation of chordoma cell line JHC7 and the identification of Brachyury as a novel molecular target. J Neurosurg. 2011 Oct; 115(4):760-9. Hsu W, Mohyeldin A, Shah SR, ap Rhys CM, Johnson LF, Sedora-Roman NI, Kosztowski TA, Awad OA, McCarthy EF, Loeb DM, Wolinsky JP, Gokaslan ZL, Quiñones-Hinojosa A. PMID: 21699479; PMCID: PMC4273567.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    43. Harvey Cushing's early experience with pediatric gliomas. Childs Nerv Syst. 2011 May; 27(5):819-24. Sedora-Román NI, Pendleton C, Mohyeldin A, Quiñones-Hinojosa A. PMID: 21287180.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    44. Mesenchymal stem cells: new approaches for the treatment of neurological diseases. Curr Stem Cell Res Ther. 2010 Dec; 5(4):326-44. Momin EN, Mohyeldin A, Zaidi HA, Vela G, Quiñones-Hinojosa A. PMID: 20528757.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    45. Oxygen in stem cell biology: a critical component of the stem cell niche. Cell Stem Cell. 2010 Aug 06; 7(2):150-61. Mohyeldin A, Garzón-Muvdi T, Quiñones-Hinojosa A. PMID: 20682444.
      View in: PubMed   Mentions: 520     Fields:    Translation:HumansAnimalsCells
    46. Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons. Glia. 2010 Aug; 58(10):1168-76. Halim ND, Mcfate T, Mohyeldin A, Okagaki P, Korotchkina LG, Patel MS, Jeoung NH, Harris RA, Schell MJ, Verma A. PMID: 20544852; PMCID: PMC2915787.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    47. Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells. J Biol Chem. 2008 Aug 15; 283(33):22700-8. McFate T, Mohyeldin A, Lu H, Thakar J, Henriques J, Halim ND, Wu H, Schell MJ, Tsang TM, Teahan O, Zhou S, Califano JA, Jeoung NH, Harris RA, Verma A. PMID: 18541534; PMCID: PMC2504897.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansCells
    48. Survival and invasiveness of astrocytomas promoted by erythropoietin. J Neurosurg. 2007 Feb; 106(2):338-50. Mohyeldin A, Dalgard CL, Lu H, Mcfate T, Tait AS, Patel VC, Wong K, Rushing E, Roy S, Acs G, Verma A. PMID: 17410721.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    49. Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1. J Biol Chem. 2005 Dec 23; 280(51):41928-39. Lu H, Dalgard CL, Mohyeldin A, McFate T, Tait AS, Verma A. PMID: 16223732.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansCells
    50. Erythropoietin receptor function and expression in epithelial ovarian carcinoma. Gynecol Oncol. 2005 Dec; 99(3):571-7. McBroom JW, Acs G, Rose GS, Krivak TC, Mohyeldin A, Verma A. PMID: 16051335.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    51. Erythropoietin signaling promotes invasiveness of human head and neck squamous cell carcinoma. Neoplasia. 2005 May; 7(5):537-43. Mohyeldin A, Lu H, Dalgard C, Lai SY, Cohen N, Acs G, Verma A. PMID: 15967106; PMCID: PMC1501166.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    52. Endogenous 2-oxoacids differentially regulate expression of oxygen sensors. Biochem J. 2004 Jun 01; 380(Pt 2):419-24. Dalgard CL, Lu H, Mohyeldin A, Verma A. PMID: 14984367; PMCID: PMC1224179.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    53. Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progression. Am J Pathol. 2003 Jun; 162(6):1789-806. Acs G, Zhang PJ, McGrath CM, Acs P, McBroom J, Mohyeldin A, Liu S, Lu H, Verma A. PMID: 12759237; PMCID: PMC1868129.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
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