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Ovariectomy Reduces Vasocontractile Responses of Rat Middle Cerebral Arteries After Focal Cerebral Ischemia. J Cardiovasc Pharmacol. 2022 01 01; 79(1):e122-e128.
Rehnström M, Ahnstedt H, Krause DN, Edvinsson ML, Haanes KA, Edvinsson L. PMID: 34654785.
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1 Fields:
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Animals
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Hormonal influences in migraine - interactions of oestrogen, oxytocin and CGRP. Nat Rev Neurol. 2021 10; 17(10):621-633.
Krause DN, Warfvinge K, Haanes KA, Edvinsson L. PMID: 34545218.
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33 Fields:
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Humans
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Estrogen receptors α, β and GPER in the CNS and trigeminal system - molecular and functional aspects. J Headache Pain. 2020 Nov 10; 21(1):131.
Warfvinge K, Krause DN, Maddahi A, Edvinsson JCA, Edvinsson L, Haanes KA. PMID: 33167864; PMCID: PMC7653779.
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38 Fields:
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HumansAnimalsCells
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Oxytocin as a regulatory neuropeptide in the trigeminovascular system: Localization, expression and function of oxytocin and oxytocin receptors. Cephalalgia. 2020 10; 40(12):1283-1295.
Warfvinge K, Krause DN, Maddahi A, Grell AS, Edvinsson JC, Haanes KA, Edvinsson L. PMID: 32486908.
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16 Fields:
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AnimalsCells
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C-fibers may modulate adjacent Aδ-fibers through axon-axon CGRP signaling at nodes of Ranvier in the trigeminal system. J Headache Pain. 2019 Nov 12; 20(1):105.
Edvinsson JCA, Warfvinge K, Krause DN, Blixt FW, Sheykhzade M, Edvinsson L, Haanes KA. PMID: 31718551; PMCID: PMC6852900.
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47 Fields:
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AnimalsCells
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CGRP as the target of new migraine therapies - successful translation from bench to clinic. Nat Rev Neurol. 2018 06; 14(6):338-350.
Edvinsson L, Haanes KA, Warfvinge K, Krause DN. PMID: 29691490.
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335 Fields:
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Humans
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U0126 attenuates cerebral vasoconstriction and improves long-term neurologic outcome after stroke in female rats. J Cereb Blood Flow Metab. 2015 Mar; 35(3):454-60.
Ahnstedt H, Mostajeran M, Blixt FW, Warfvinge K, Ansar S, Krause DN, Edvinsson L. PMID: 25492115; PMCID: PMC4348385.
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22 Fields:
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AnimalsCells
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Genomic and non-genomic regulation of PGC1 isoforms by estrogen to increase cerebral vascular mitochondrial biogenesis and reactive oxygen species protection. Eur J Pharmacol. 2014 Jan 15; 723:322-9.
Kemper MF, Stirone C, Krause DN, Duckles SP, Procaccio V. PMID: 24275351; PMCID: PMC4028038.
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21 Fields:
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AnimalsCells
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Male-female differences in upregulation of vasoconstrictor responses in human cerebral arteries. PLoS One. 2013; 8(4):e62698.
Ahnstedt H, Cao L, Krause DN, Warfvinge K, Säveland H, Nilsson OG, Edvinsson L. PMID: 23658641; PMCID: PMC3639206.
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PubMed Mentions:
20 Fields:
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HumansCells
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Endogenous ovarian hormones affect mitochondrial efficiency in cerebral endothelium via distinct regulation of PGC-1 isoforms. J Cereb Blood Flow Metab. 2013 Jan; 33(1):122-8.
Kemper MF, Zhao Y, Duckles SP, Krause DN. PMID: 23093066; PMCID: PMC3597365.
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19 Fields:
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AnimalsCells
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17β-Estradiol prevents cell death and mitochondrial dysfunction by an estrogen receptor-dependent mechanism in astrocytes after oxygen-glucose deprivation/reperfusion. Free Radic Biol Med. 2012 Jun 1-15; 52(11-12):2151-60.
Guo J, Duckles SP, Weiss JH, Li X, Krause DN. PMID: 22554613; PMCID: PMC3377773.
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PubMed Mentions:
36 Fields:
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AnimalsCells
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International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors. Pharmacol Rev. 2010 Sep; 62(3):343-80.
Dubocovich ML, Delagrange P, Krause DN, Sugden D, Cardinali DP, Olcese J. PMID: 20605968; PMCID: PMC2964901.
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191 Fields:
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HumansAnimals
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[Mechanism of estrogen-mediated neuroprotection: regulation of mitochondrial function]. Sheng Li Ke Xue Jin Zhan. 2010 Jun; 41(3):165-70.
Guo JB, Tie L, Krause DN, Duckles SP, Li XJ. PMID: 21416974.
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HumansAnimalsCells
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Estrogen-receptor-mediated protection of cerebral endothelial cell viability and mitochondrial function after ischemic insult in vitro. J Cereb Blood Flow Metab. 2010 Mar; 30(3):545-54.
Guo J, Krause DN, Horne J, Weiss JH, Li X, Duckles SP. PMID: 19861973; PMCID: PMC2831126.
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35 Fields:
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AnimalsCells
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Dihydrotestosterone stimulates cerebrovascular inflammation through NFkappaB, modulating contractile function. J Cereb Blood Flow Metab. 2009 Feb; 29(2):244-53.
Gonzales RJ, Duckles SP, Krause DN. PMID: 18941467; PMCID: PMC2658637.
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PubMed Mentions:
25 Fields:
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Animals
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Mitochondrial effects of estrogen are mediated by estrogen receptor alpha in brain endothelial cells. J Pharmacol Exp Ther. 2008 Jun; 325(3):782-90.
Razmara A, Sunday L, Stirone C, Wang XB, Krause DN, Duckles SP, Procaccio V. PMID: 18354059; PMCID: PMC2650426.
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67 Fields:
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HumansCells
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Estrogen suppresses brain mitochondrial oxidative stress in female and male rats. Brain Res. 2007 Oct 24; 1176:71-81.
Razmara A, Duckles SP, Krause DN, Procaccio V. PMID: 17889838; PMCID: PMC2099309.
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68 Fields:
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AnimalsCells
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Cerebrovascular effects of oestrogen: multiplicity of action. Clin Exp Pharmacol Physiol. 2007 Aug; 34(8):801-8.
Duckles SP, Krause DN. PMID: 17600562.
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44 Fields:
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HumansAnimalsCells
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Androgenic/estrogenic balance in the male rat cerebral circulation: metabolic enzymes and sex steroid receptors. J Cereb Blood Flow Metab. 2007 Nov; 27(11):1841-52.
Gonzales RJ, Ansar S, Duckles SP, Krause DN. PMID: 17406656; PMCID: PMC2198927.
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29 Fields:
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Animals
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Age alters cerebrovascular inflammation and effects of estrogen. Am J Physiol Heart Circ Physiol. 2007 May; 292(5):H2333-40.
Sunday L, Osuna C, Krause DN, Duckles SP. PMID: 17208996; PMCID: PMC2198924.
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26 Fields:
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Animals
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Influence of sex steroid hormones on cerebrovascular function. J Appl Physiol (1985). 2006 Oct; 101(4):1252-61.
Krause DN, Duckles SP, Pelligrino DA. PMID: 16794020.
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PubMed Mentions:
168 Fields:
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Animals
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Estrogen and progestagens differentially modulate vascular proinflammatory factors. Am J Physiol Endocrinol Metab. 2006 Aug; 291(2):E261-7.
Sunday L, Tran MM, Krause DN, Duckles SP. PMID: 16492687; PMCID: PMC2198926.
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PubMed Mentions:
31 Fields:
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Animals
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Estrogen and mitochondria: a new paradigm for vascular protection? Mol Interv. 2006 Feb; 6(1):26-35.
Duckles SP, Krause DN, Stirone C, Procaccio V. PMID: 16507748.
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PubMed Mentions:
38 Fields:
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HumansAnimalsCells
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Testosterone augments endotoxin-mediated cerebrovascular inflammation in male rats. Am J Physiol Heart Circ Physiol. 2005 Nov; 289(5):H1843-50.
Razmara A, Krause DN, Duckles SP. PMID: 16006544.
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PubMed Mentions:
22 Fields:
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Animals
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Estrogen increases mitochondrial efficiency and reduces oxidative stress in cerebral blood vessels. Mol Pharmacol. 2005 Oct; 68(4):959-65.
Stirone C, Duckles SP, Krause DN, Procaccio V. PMID: 15994367.
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PubMed Mentions:
115 Fields:
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AnimalsCells
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Testosterone treatment increases thromboxane function in rat cerebral arteries. Am J Physiol Heart Circ Physiol. 2005 Aug; 289(2):H578-85.
Gonzales RJ, Ghaffari AA, Duckles SP, Krause DN. PMID: 15764681.
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PubMed Mentions:
35 Fields:
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Animals
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Estrogen receptor activation of phosphoinositide-3 kinase, akt, and nitric oxide signaling in cerebral blood vessels: rapid and long-term effects. Mol Pharmacol. 2005 Jan; 67(1):105-13.
Stirone C, Boroujerdi A, Duckles SP, Krause DN. PMID: 15496504.
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PubMed Mentions:
60 Fields:
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AnimalsCells
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Effect of estrogen on cerebrovascular prostaglandins is amplified in mice with dysfunctional NOS. Am J Physiol Heart Circ Physiol. 2004 Aug; 287(2):H588-94.
Li X, Geary GG, Gonzales RJ, Krause DN, Duckles SP. PMID: 15277199.
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PubMed Mentions:
12 Fields:
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Animals
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Estrogen suppresses IL-1beta-mediated induction of COX-2 pathway in rat cerebral blood vessels. Am J Physiol Heart Circ Physiol. 2004 May; 286(5):H2010-9.
Ospina JA, Brevig HN, Krause DN, Duckles SP. PMID: 14684367.
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PubMed Mentions:
38 Fields:
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Animals
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Testosterone suppresses endothelium-dependent dilation of rat middle cerebral arteries. Am J Physiol Heart Circ Physiol. 2004 Feb; 286(2):H552-60.
Gonzales RJ, Krause DN, Duckles SP. PMID: 14551047.
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PubMed Mentions:
31 Fields:
Translation:
Animals
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17 Beta-estradiol increases endothelial nitric oxide synthase mRNA copy number in cerebral blood vessels: quantification by real-time polymerase chain reaction. Eur J Pharmacol. 2003 Sep 30; 478(1):35-8.
Stirone C, Chu Y, Sunday L, Duckles SP, Krause DN. PMID: 14555182.
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PubMed Mentions:
25 Fields:
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Animals
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17beta-estradiol decreases vascular tone in cerebral arteries by shifting COX-dependent vasoconstriction to vasodilation. Am J Physiol Heart Circ Physiol. 2003 Jul; 285(1):H241-50.
Ospina JA, Duckles SP, Krause DN. PMID: 12637362.
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PubMed Mentions:
44 Fields:
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Animals
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Vascular neuroeffector mechanisms: the next 30 years. Trends Pharmacol Sci. 2002 Dec; 23(12):541-2.
Krause DN, Purdy RE, Pearce WJ, Duckles SP. PMID: 12457765.
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HumansAnimalsCells
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Multiple forms of estrogen receptor-alpha in cerebral blood vessels: regulation by estrogen. Am J Physiol Endocrinol Metab. 2003 Jan; 284(1):E184-92.
Stirone C, Duckles SP, Krause DN. PMID: 12388160.
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PubMed Mentions:
49 Fields:
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AnimalsCells
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MT(2) melatonin receptors are present and functional in rat caudal artery. J Pharmacol Exp Ther. 2002 Sep; 302(3):1295-302.
Masana MI, Doolen S, Ersahin C, Al-Ghoul WM, Duckles SP, Dubocovich ML, Krause DN. PMID: 12183692.
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PubMed Mentions:
46 Fields:
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AnimalsCells
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Male-female differences in the relative contribution of endothelial vasodilators released by rat tail artery. Life Sci. 2002 Aug 23; 71(14):1633-42.
Pak KJ, Geary GG, Duckles SP, Krause DN. PMID: 12137910.
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PubMed Mentions:
10 Fields:
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Animals
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Regional differences in the effect of oestrogen on vascular tone in isolated rabbit arteries. Pharmacol Toxicol. 2002 Aug; 91(2):77-82.
Saetrum Opgaard O, Duckles SP, Krause DN. PMID: 12420796.
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PubMed Mentions:
3 Fields:
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Animals
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Estrogen increases endothelial nitric oxide synthase via estrogen receptors in rat cerebral blood vessels: effect preserved after concurrent treatment with medroxyprogesterone acetate or progesterone. Stroke. 2002 Jun; 33(6):1685-91.
McNeill AM, Zhang C, Stanczyk FZ, Duckles SP, Krause DN. PMID: 12053012.
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PubMed Mentions:
49 Fields:
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AnimalsCells
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17beta-estradiol increases rat cerebrovascular prostacyclin synthesis by elevating cyclooxygenase-1 and prostacyclin synthase. Stroke. 2002 Feb; 33(2):600-5.
Ospina JA, Krause DN, Duckles SP. PMID: 11823676.
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PubMed Mentions:
42 Fields:
Translation:
Animals