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Trina M Norden-Krichmar

Title(s)Professor Emeritus, Epidemiology and Biostats
SchoolUC Irvine Joe C. Wen School of Population & Public Health
Address856 Health Sciences Quad
University of California, Irvine
Irvine CA 92697-3957
Phone(949) 824-0306
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    Collapse Research 
    Collapse research activities and funding
    Transcriptomics of Liver in Alcoholic Hepatitis
    NIH U01AA021838Jan 1, 2013 - Dec 31, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Germline Variants Influence Chronic Liver Disease Progression through Distinct Pathways. medRxiv. 2025 Sep 18. Vujkovic M, Kaplan DE, Ghouse J, Loza BL, Brancale J, Lewis A, Zhang DY, Levin MG, Veatch OJ, Johnson JP, Schneider CV, Verma A, Wangensteen KJ, Scorletti E, Gill D, Konkwo C, Garófalo AM, Guare LA, Schwantes-An TW, Abreu MV, Gellert-Kristensen H, Pedersen OB, Erikstrup C, Bundgaard JS, Sørensen E, Ostrowski SR, Bundgaard H, Lee KM, Shaked A, Olthoff KM, Hoteit MA, Speliotes EK, Chen Y, Oliveri A, Yin L, Valenti LV, Malvestiti F, Marchelli D, Miano L, Anstee QM, Daly AK, Cordell HJ, Darlay R, Verweij N, Hindy G, Locke A, Matsuura K, Asrani SK, Testa G, Lotta LA, Jones MB, Dochtermann DR, Norden-Krichmar TM, Teerlink CC, Devineni P, Pyarajan S, Rader DJ, Tanaka Y, Voight BF, Vilarinho S, Bastarache LA, Stender S, Tsao PS, Penn Medicine Biobank, DBDS Genomic Consortium, BioVU Biobank, Michigan Genomics Initiative, Regeneron Genetics Center, Indiana Biobank, All Of Us Research Program, Milano Biobank, LITMUS Consortium, VA Million Veteran Program, Morgan TR, Lynch JA, Chang KM. PMID: 41001506; PMCID: PMC12458504.
      View in: PubMed   Mentions:
    2. Clinical and genetic risk factors for progressive fibrosis in metabolic dysfunction-associated steatotic liver disease. Hepatol Commun. 2024 07 01; 8(7). Kaplan DE, Teerlink CC, Schwantes-An TH, Norden-Krichmar TM, DuVall SL, Morgan TR, Tsao PS, Voight BF, Lynch JA, Vujkovic M, Chang KM. PMID: 38967582; PMCID: PMC11227360.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    3. Identification of integrated proteomics and transcriptomics signature of alcohol-associated liver disease using machine learning. PLOS Digit Health. 2024 Feb; 3(2):e0000447. Listopad S, Magnan C, Day LZ, Asghar A, Stolz A, Tayek JA, Liu ZX, Jacobs JM, Morgan TR, Norden-Krichmar TM. PMID: 38335183; PMCID: PMC10857706.
      View in: PubMed   Mentions: 2  
    4. Single-cell transcriptomics of peripheral blood mononuclear cells indicates impaired immune and inflammatory responses in alcohol-associated hepatitis. Hum Immunol. 2024 Jan; 85(1):110735. Liu X, Liu ZX, Morgan TR, Norden-Krichmar TM. PMID: 38040543; PMCID: PMC12549007.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Heterogeneity in familial clustering of metabolic syndrome components in the multiethnic GENNID study. Obesity (Silver Spring). 2024 01; 32(1):176-186. Wan JY, Goodman D, Makhnoon S, Norden-Krichmar TM, Wu B, Edwards KL. PMID: 37823211; PMCID: PMC10872471.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Genomic approaches to explore susceptibility and pathogenesis of alcohol use disorder and alcohol-associated liver disease. Hepatology. 2025 May 01; 81(5):1595-1606. Norden-Krichmar TM, Rotroff D, Schwantes-An TH, Bataller R, Goldman D, Nagy LE, Liangpunsakul S. PMID: 37796138; PMCID: PMC10985049.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. Predicting moderate drinking behaviors in National Health and Nutrition Examination Survey participants using biochemical and demographical factors with machine learning. Alcohol. 2023 12; 113:1-10. Leaks K, Norden-Krichmar T, Brody JP. PMID: 37543050.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Urinary glyphosate and AMPA levels in a cross-sectional study of postmenopausal women: Associations with organic eating behavior and dietary intake. Int J Hyg Environ Health. 2023 07; 252:114211. Lucia RM, Liao X, Huang WL, Forman D, Kim A, Ziogas A, Norden-Krichmar TM, Goodman D, Alvarez A, Masunaka I, Pathak KV, McGilvrey M, Hegde AM, Pirrotte P, Park HL. PMID: 37393842; PMCID: PMC10503538.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    9. Integrated Transcriptomic and Proteomic Analysis Identifies Plasma Biomarkers of Hepatocellular Failure in Alcohol-Associated Hepatitis. Am J Pathol. 2022 12; 192(12):1658-1669. Argemi J, Kedia K, Gritsenko MA, Clemente-Sanchez A, Asghar A, Herranz JM, Liu ZX, Atkinson SR, Smith RD, Norden-Krichmar TM, Day LZ, Stolz A, Tayek JA, Bataller R, Morgan TR, Jacobs JM, Southern California Alcoholic Hepatitis Consortium and the InTeam Consortium. PMID: 36243044; PMCID: PMC9765311.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    10. Differentiating between liver diseases by applying multiclass machine learning approaches to transcriptomics of liver tissue or blood-based samples. JHEP Rep. 2022 Oct; 4(10):100560. Listopad S, Magnan C, Asghar A, Stolz A, Tayek JA, Liu ZX, Morgan TR, Norden-Krichmar TM. PMID: 36119721; PMCID: PMC9472076.
      View in: PubMed   Mentions: 4  
    11. Association of Glyphosate Exposure with Blood DNA Methylation in a Cross-Sectional Study of Postmenopausal Women. Environ Health Perspect. 2022 04; 130(4):47001. Lucia RM, Huang WL, Pathak KV, McGilvrey M, David-Dirgo V, Alvarez A, Goodman D, Masunaka I, Odegaard AO, Ziogas A, Pirrotte P, Norden-Krichmar TM, Park HL. PMID: 35377194; PMCID: PMC8978648.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    12. DEGnext: classification of differentially expressed genes from RNA-seq data using a convolutional neural network with transfer learning. BMC Bioinformatics. 2022 Jan 06; 23(1):17. Kakati T, Bhattacharyya DK, Kalita JK, Norden-Krichmar TM. PMID: 34991439; PMCID: PMC8734099.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    13. Genetic signature of human longevity in PKC and NF-κB signaling. Aging Cell. 2021 07; 20(7):e13362. Ryu S, Han J, Norden-Krichmar TM, Zhang Q, Lee S, Zhang Z, Atzmon G, Niedernhofer LJ, Robbins PD, Barzilai N, Schork NJ, Suh Y. PMID: 34197020; PMCID: PMC8282271.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    14. Association of mammographic density with blood DNA methylation. Epigenetics. 2022 05; 17(5):531-546. Lucia RM, Huang WL, Alvarez A, Masunaka I, Ziogas A, Goodman D, Odegaard AO, Norden-Krichmar TM, Park HL. PMID: 34116608; PMCID: PMC9067527.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    15. Genome-wide association analysis of metabolic syndrome quantitative traits in the GENNID multiethnic family study. Diabetol Metab Syndr. 2021 Jun 01; 13(1):59. Wan JY, Goodman DL, Willems EL, Freedland AR, Norden-Krichmar TM, Santorico SA, Edwards KL, American Diabetes GENNID Study Group. PMID: 34074324; PMCID: PMC8170963.
      View in: PubMed   Mentions: 12  
    16. Gene expression profiling of fibroblasts in a family with LMNA-related cardiomyopathy reveals molecular pathways implicated in disease pathogenesis. BMC Med Genet. 2020 07 22; 21(1):152. Widyastuti HP, Norden-Krichmar TM, Grosberg A, Zaragoza MV. PMID: 32698886; PMCID: PMC7374820.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    17. Rationale, Study Design, and Cohort Characteristics for the Markers for Environmental Exposures (MEE) Study. Int J Environ Res Public Health. 2020 03 09; 17(5). Lucia RM, Huang WL, Alvarez A, Thampy D, Elyasian M, Hidajat A, Yang K, Forman D, Pebdani A, Masunaka I, Brain S, Heditsian D, Lee V, Goodman D, Norden-Krichmar TM, Odegaard AO, Ziogas A, Park HL. PMID: 32182891; PMCID: PMC7084413.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    18. Evidence for gene-smoking interactions for hearing loss and deafness in Japanese American families. Hear Res. 2020 03 01; 387:107875. Wan JY, Cataby C, Liem A, Jeffrey E, Norden-Krichmar TM, Goodman D, Santorico SA, Edwards KL, American Diabetes Association GENNID Study Group. PMID: 31896498; PMCID: PMC7046312.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    19. A-Lister: a tool for analysis of differentially expressed omics entities across multiple pairwise comparisons. BMC Bioinformatics. 2019 Nov 19; 20(1):595. Listopad SA, Norden-Krichmar TM. PMID: 31744472; PMCID: PMC6862834.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. Transethnic meta-analysis of metabolic syndrome in a multiethnic study. Genet Epidemiol. 2020 01; 44(1):16-25. Willems EL, Wan JY, Norden-Krichmar TM, Edwards KL, Santorico SA. PMID: 31647587; PMCID: PMC6986323.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    21. Effective discovery of rare variants by pooled target capture sequencing: A comparative analysis with individually indexed target capture sequencing. Mutat Res. 2018 05; 809:24-31. Ryu S, Han J, Norden-Krichmar TM, Schork NJ, Suh Y. PMID: 29677560; PMCID: PMC5962423.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    22. Identification of a gene expression signature predicting survival in oral cavity squamous cell carcinoma using Monte Carlo cross validation. Oral Oncol. 2018 03; 78:72-79. Schomberg J, Ziogas A, Anton-Culver H, Norden-Krichmar T. PMID: 29496061; PMCID: PMC7853240.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    23. Variants Near CCK Receptors are Associated With Electrophysiological Responses to Pre-pulse Startle Stimuli in a Mexican American Cohort. Twin Res Hum Genet. 2015 Dec; 18(6):727-37. Norden-Krichmar TM, Gizer IR, Phillips E, Wilhelmsen KC, Schork NJ, Ehlers CL. PMID: 26608796; PMCID: PMC4727900.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    24. Microbial metabolic networks in a complex electrogenic biofilm recovered from a stimulus-induced metatranscriptomics approach. Sci Rep. 2015 Oct 07; 5:14840. Ishii S, Suzuki S, Tenney A, Norden-Krichmar TM, Nealson KH, Bretschger O. PMID: 26443302; PMCID: PMC4595844.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    25. Protective variant associated with alcohol dependence in a Mexican American cohort. BMC Med Genet. 2014 Dec 21; 15:136. Norden-Krichmar TM, Gizer IR, Wilhelmsen KC, Schork NJ, Ehlers CL. PMID: 25527893; PMCID: PMC4337107.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    26. Correlation analysis of genetic admixture and social identification with body mass index in a Native American community. Am J Hum Biol. 2014 May-Jun; 26(3):347-60. Norden-Krichmar TM, Gizer IR, Libiger O, Wilhelmsen KC, Ehlers CL, Schork NJ. PMID: 24757035; PMCID: PMC4068510.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    27. Microbial population and functional dynamics associated with surface potential and carbon metabolism. ISME J. 2014 May; 8(5):963-78. Ishii S, Suzuki S, Norden-Krichmar TM, Phan T, Wanger G, Nealson KH, Sekiguchi Y, Gorby YA, Bretschger O. PMID: 24351938; PMCID: PMC3996694.
      View in: PubMed   Mentions: 41     Fields:    Translation:CellsPHPublic Health
    28. Identifying the microbial communities and operational conditions for optimized wastewater treatment in microbial fuel cells. Water Res. 2013 Dec 01; 47(19):7120-30. Ishii S, Suzuki S, Norden-Krichmar TM, Wu A, Yamanaka Y, Nealson KH, Bretschger O. PMID: 24183402.
      View in: PubMed   Mentions: 13     Fields:    Translation:CellsPHPublic Health
    29. A novel metatranscriptomic approach to identify gene expression dynamics during extracellular electron transfer. Nat Commun. 2013; 4:1601. Ishii S, Suzuki S, Norden-Krichmar TM, Tenney A, Chain PS, Scholz MB, Nealson KH, Bretschger O. PMID: 23511466.
      View in: PubMed   Mentions: 57     Fields:    Translation:Cells
    30. Whole transcriptome analysis of the silicon response of the diatom Thalassiosira pseudonana. BMC Genomics. 2012 Sep 20; 13:499. Shrestha RP, Tesson B, Norden-Krichmar T, Federowicz S, Hildebrand M, Allen AE. PMID: 22994549; PMCID: PMC3478156.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    31. Influence of cobalamin scarcity on diatom molecular physiology and identification of a cobalamin acquisition protein. Proc Natl Acad Sci U S A. 2012 Jun 26; 109(26):E1762-71. Bertrand EM, Allen AE, Dupont CL, Norden-Krichmar TM, Bai J, Valas RE, Saito MA. PMID: 22652568; PMCID: PMC3387067.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    32. Functionally stable and phylogenetically diverse microbial enrichments from microbial fuel cells during wastewater treatment. PLoS One. 2012; 7(2):e30495. Ishii S, Suzuki S, Norden-Krichmar TM, Nealson KH, Sekiguchi Y, Gorby YA, Bretschger O. PMID: 22347379; PMCID: PMC3274515.
      View in: PubMed   Mentions: 24     Fields:    Translation:PHPublic Health
    33. Characterization of the small RNA transcriptome of the diatom, Thalassiosira pseudonana. PLoS One. 2011; 6(8):e22870. Norden-Krichmar TM, Allen AE, Gaasterland T, Hildebrand M. PMID: 21857960; PMCID: PMC3155517.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    34. Computational prediction and experimental validation of Ciona intestinalis microRNA genes. BMC Genomics. 2007 Nov 29; 8:445. Norden-Krichmar TM, Holtz J, Pasquinelli AE, Gaasterland T. PMID: 18047675; PMCID: PMC2243180.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    35. Modulation of oligosynaptic cutaneous and muscle afferent reflex pathways during fictive locomotion and scratching in the cat. J Neurophysiol. 1998 Jan; 79(1):447-63. Degtyarenko AM, Simon ES, Norden-Krichmar T, Burke RE. PMID: 9425213.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
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