Parsons, Michael J

TitleAssociate Professor
InstitutionUniversity of California, Irvine
DepartmentDevelopmental & Cell Biology
Address4361 Natural Sciences II
Zot 2305
CA 92697
Phone(949) 824-8728
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    Collapse Research 
    Collapse Research Activities and Funding
    High-Throughput Screen For FDA Approved Drugs That Amplify Beta-Cell Mass In Vivo
    NIH/NIDDK RC4DK090816Sep 30, 2010 - Aug 31, 2013
    Role: Co-Principal Investigator
    Transgenic tools for Gal4 regulated gene expression in zebrafish
    NIH/NICHD R01HD058530Aug 1, 2008 - May 31, 2013
    Role: Co-Principal Investigator
    Characterizing the Role of Pancreatic Progenitors in Regeneration
    NIH/NIDDK R01DK080730Apr 1, 2008 - May 31, 2022
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Garzia L, Kijima N, Morrissy AS, De Antonellis P, Guerreiro-Stucklin A, Holgado BL, Wu X, Wang X, Parsons M, Zayne K, Manno A, Kuzan-Fischer C, Nor C, Donovan LK, Liu J, Qin L, Garancher A, Liu KW, Mansouri S, Luu B, Thompson YY, Ramaswamy V, Peacock J, Farooq H, Skowron P, Shih DJH, Li A, Ensan S, Robbins CS, Cybulsky M, Mitra S, Ma Y, Moore R, Mungall A, Cho YJ, Weiss WA, Chan JA, Hawkins CE, Massimino M, Jabado N, Zapotocky M, Sumerauer D, Bouffet E, Dirks P, Tabori U, Sorensen PHB, Brastianos PK, Aldape K, Jones SJM, Marra MA, Woodgett JR, Wechsler-Reya RJ, Fults DW, Taylor MD. A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases. Cell. 2018 May 31; 173(6):1549. PMID: 29856958.
      View in: PubMed
    2. Garzia L, Kijima N, Morrissy AS, De Antonellis P, Guerreiro-Stucklin A, Holgado BL, Wu X, Wang X, Parsons M, Zayne K, Manno A, Kuzan-Fischer C, Nor C, Donovan LK, Liu J, Qin L, Garancher A, Liu KW, Mansouri S, Luu B, Thompson YY, Ramaswamy V, Peacock J, Farooq H, Skowron P, Shih DJH, Li A, Ensan S, Robbins CS, Cybulsky M, Mitra S, Ma Y, Moore R, Mungall A, Cho YJ, Weiss WA, Chan JA, Hawkins CE, Massimino M, Jabado N, Zapotocky M, Sumerauer D, Bouffet E, Dirks P, Tabori U, Sorensen PHB, Brastianos PK, Aldape K, Jones SJM, Marra MA, Woodgett JR, Wechsler-Reya RJ, Fults DW, Taylor MD. A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases. Cell. 2018 Feb 22; 172(5):1050-1062.e14. PMID: 29474906.
      View in: PubMed
    3. Zhang D, Gates KP, Barske L, Wang G, Lancman JJ, Zeng XI, Groff M, Wang K, Parsons M, Crump JG, Dong PDS. Endoderm Jagged induces liver and pancreas duct lineage in zebrafish. Nat Commun. 2017 10 03; 8(1):769. PMID: 28974684.
      View in: PubMed
    4. Wilcox AG, Vizor L, Parsons M, Banks G, Nolan PM. Inducible Knockout of Mouse Zfhx3 Emphasizes Its Key Role in Setting the Pace and Amplitude of the Adult Circadian Clock. J Biol Rhythms. 2017 Oct; 32(5):433-443. PMID: 28816086.
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    5. Janecka M, Marzi SJ, Parsons M, Liu L, Paya-Cano JL, Smith RG, Fernandes C, Schalkwyk LC. Genetic polymorphisms and their association with brain and behavioural measures in heterogeneous stock mice. Sci Rep. 2017 Feb 01; 7:41204. PMID: 28145470.
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    6. Huang W, Beer RL, Delaspre F, Wang G, Edelman HE, Park H, Azuma M, Parsons M. Sox9b is a mediator of retinoic acid signaling restricting endocrine progenitor differentiation. Dev Biol. 2016 10 01; 418(1):28-39. PMID: 27565026.
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    7. Balzani E, Lassi G, Maggi S, Sethi S, Parsons M, Simon M, Nolan PM, Tucci V. The Zfhx3-Mediated Axis Regulates Sleep and Interval Timing in Mice. Cell Rep. 2016 07 19; 16(3):615-21. PMID: 27373158.
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    8. Johnson K, Barragan J, Bashiruddin S, Smith CJ, Tyrrell C, Parsons M, Doris R, Kucenas S, Downes GB, Velez CM, Schneider C, Sakai C, Pathak N, Anderson K, Stein R, Devoto SH, Mumm JS, Barresi MJ. Gfap-positive radial glial cells are an essential progenitor population for later-born neurons and glia in the zebrafish spinal cord. Glia. 2016 07; 64(7):1170-89. PMID: 27100776.
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    9. de la Hoya M, Soukarieh O, López-Perolio I, Vega A, Walker LC, van Ierland Y, Baralle D, Santamariña M, Lattimore V, Wijnen J, Whiley P, Blanco A, Raponi M, Hauke J, Wappenschmidt B, Becker A, Hansen TV, Behar R, Investigators K, Niederacher D, Arnold N, Dworniczak B, Steinemann D, Faust U, Rubinstein W, Hulick PJ, Houdayer C, Caputo SM, Castera L, Pesaran T, Chao E, Brewer C, Southey MC, van Asperen CJ, Singer CF, Sullivan J, Poplawski N, Mai P, Peto J, Johnson N, Burwinkel B, Surowy H, Bojesen SE, Flyger H, Lindblom A, Margolin S, Chang-Claude J, Rudolph A, Radice P, Galastri L, Olson JE, Hallberg E, Giles GG, Milne RL, Andrulis IL, Glendon G, Hall P, Czene K, Blows F, Shah M, Wang Q, Dennis J, Michailidou K, McGuffog L, Bolla MK, Antoniou AC, Easton DF, Couch FJ, Tavtigian S, Vreeswijk MP, Parsons M, Meeks HD, Martins A, Goldgar DE, Spurdle AB. Combined genetic and splicing analysis of BRCA1 c.[594-2A>C; 641A>G] highlights the relevance of naturally occurring in-frame transcripts for developing disease gene variant classification algorithms. Hum Mol Genet. 2016 06 01; 25(11):2256-2268. PMID: 27008870.
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    10. Beer RL, Parsons M, Rovira M. Centroacinar cells: At the center of pancreas regeneration. Dev Biol. 2016 May 01; 413(1):8-15. PMID: 26963675; PMCID: PMC4834238 [Available on 05/01/17].
    11. Militi S, Maywood ES, Sandate CR, Chesham JE, Barnard AR, Parsons M, Vibert JL, Joynson GM, Partch CL, Hastings MH, Nolan PM. Early doors (Edo) mutant mouse reveals the importance of period 2 (PER2) PAS domain structure for circadian pacemaking. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):2756-61. PMID: 26903623; PMCID: PMC4791021.
    12. Wong CC, Parsons M, Lester KJ, Burrage J, Eley TC, Mill J, Dempster EL, Gregory AM. Epigenome-Wide DNA Methylation Analysis of Monozygotic Twins Discordant for Diurnal Preference. Twin Res Hum Genet. 2015 Dec; 18(6):662-9. PMID: 26678051.
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    13. Parsons M, Brancaccio M, Sethi S, Maywood ES, Satija R, Edwards JK, Jagannath A, Couch Y, Finelli MJ, Smyllie NJ, Esapa C, Butler R, Barnard AR, Chesham JE, Saito S, Joynson G, Wells S, Foster RG, Oliver PL, Simon MM, Mallon AM, Hastings MH, Nolan PM. The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis. Cell. 2015 Jul 30; 162(3):607-21. PMID: 26232227; PMCID: PMC4537516.
    14. Wang G, Rajpurohit SK, Delaspre F, Walker SL, White DT, Ceasrine A, Kuruvilla R, Li RJ, Shim JS, Liu JO, Parsons M, Mumm JS. First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic ß-cell mass. Elife. 2015 Jul 28; 4. PMID: 26218223; PMCID: PMC4534842.
    15. Delaspre F, Beer RL, Rovira M, Huang W, Wang G, Gee S, Vitery Mdel C, Wheelan SJ, Parsons M. Centroacinar Cells Are Progenitors That Contribute to Endocrine Pancreas Regeneration. Diabetes. 2015 Oct; 64(10):3499-509. PMID: 26153247; PMCID: PMC4587647 [Available on 10/01/16].
    16. Wang YJ, Park JT, Parsons M, Leach SD. Fate mapping of ptf1a-expressing cells during pancreatic organogenesis and regeneration in zebrafish. Dev Dyn. 2015 Jun; 244(6):724-35. PMID: 25773748; PMCID: PMC4838417.
    17. Fischer A, Wolman M, Granato M, Parsons M, McCallion AS, Proescher J, English E. Carbamate nerve agent prophylatics exhibit distinct toxicological effects in the zebrafish embryo model. Neurotoxicol Teratol. 2015 Jul-Aug; 50:1-10. PMID: 25968237.
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    18. Denis D, French CC, Rowe R, Zavos HM, Nolan PM, Parsons M, Gregory AM. A twin and molecular genetics study of sleep paralysis and associated factors. J Sleep Res. 2015 Aug; 24(4):438-46. PMID: 25659590; PMCID: PMC4950339.
    19. Goldman-Mellor S, Gregory AM, Caspi A, Harrington H, Parsons M, Poulton R, Moffitt TE. Mental health antecedents of early midlife insomnia: evidence from a four-decade longitudinal study. Sleep. 2014 Nov 01; 37(11):1767-75. PMID: 25364072; PMCID: PMC4196060.
    20. Huang W, Wang G, Delaspre F, Vitery Mdel C, Beer RL, Parsons M. Retinoic acid plays an evolutionarily conserved and biphasic role in pancreas development. Dev Biol. 2014 Oct 01; 394(1):83-93. PMID: 25127993; PMCID: PMC4623430.
    21. Parsons M, Lester KJ, Barclay NL, Archer SN, Nolan PM, Eley TC, Gregory AM. Polymorphisms in the circadian expressed genes PER3 and ARNTL2 are associated with diurnal preference and GNß3 with sleep measures. J Sleep Res. 2014 Oct; 23(5):595-604. PMID: 24635757; PMCID: PMC4320759.
    22. Quillien A, Moore JC, Shin M, Siekmann AF, Smith T, Pan L, Moens CB, Parsons M, Lawson ND. Distinct Notch signaling outputs pattern the developing arterial system. Development. 2014 Apr; 141(7):1544-52. PMID: 24598161; PMCID: PMC4074308.
    23. Matsuda H, Parsons M, Leach SD. Aldh1-expressing endocrine progenitor cells regulate secondary islet formation in larval zebrafish pancreas. PLoS One. 2013; 8(9):e74350. PMID: 24147152; PMCID: PMC3798260.
    24. Parsons M, Lester KJ, Barclay NL, Nolan PM, Eley TC, Gregory AM. Replication of Genome-Wide Association Studies (GWAS) loci for sleep in the British G1219 cohort. Am J Med Genet B Neuropsychiatr Genet. 2013 Jul; 162B(5):431-8. PMID: 23780892.
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    25. Subedi A, Macurak M, Gee ST, Monge E, Goll MG, Potter CJ, Parsons M, Halpern ME. Adoption of the Q transcriptional regulatory system for zebrafish transgenesis. Methods. 2014 Apr 01; 66(3):433-40. PMID: 23792917; PMCID: PMC3883888.
    26. Barclay NL, Eley TC, Parsons M, Willis TA, Gregory AM. Monozygotic twin differences in non-shared environmental factors associated with chronotype. J Biol Rhythms. 2013 Feb; 28(1):51-61. PMID: 23382591.
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    27. Parsons M, Grimm C, Paya-Cano JL, Fernandes C, Liu L, Philip VM, Chesler EJ, Nietfeld W, Lehrach H, Schalkwyk LC. Genetic variation in hippocampal microRNA expression differences in C57BL/6 J X DBA/2 J (BXD) recombinant inbred mouse strains. BMC Genomics. 2012 Sep 13; 13:476. PMID: 22974136; PMCID: PMC3496628.
    28. Provost E, Wehner KA, Zhong X, Ashar F, Nguyen E, Green R, Parsons M, Leach SD. Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development. Development. 2012 Sep; 139(17):3232-41. PMID: 22872088; PMCID: PMC3413166.
    29. Bryson JB, Hobbs C, Parsons M, Bosch KD, Pandraud A, Walsh FS, Doherty P, Greensmith L. Amyloid precursor protein (APP) contributes to pathology in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Hum Mol Genet. 2012 Sep 01; 21(17):3871-82. PMID: 22678056.
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    30. Manfroid I, Ghaye A, Naye F, Detry N, Palm S, Pan L, Ma TP, Huang W, Rovira M, Martial JA, Parsons M, Moens CB, Voz ML, Peers B. Zebrafish sox9b is crucial for hepatopancreatic duct development and pancreatic endocrine cell regeneration. Dev Biol. 2012 Jun 15; 366(2):268-78. PMID: 22537488; PMCID: PMC3364407.
    31. Walker SL, Ariga J, Mathias JR, Coothankandaswamy V, Xie X, Distel M, Köster RW, Parsons M, Bhalla KN, Saxena MT, Mumm JS. Automated reporter quantification in vivo: high-throughput screening method for reporter-based assays in zebrafish. PLoS One. 2012; 7(1):e29916. PMID: 22238673; PMCID: PMC3251595.
    32. Rovira M, Huang W, Yusuff S, Shim JS, Ferrante AA, Liu JO, Parsons M. Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):19264-9. PMID: 22084084; PMCID: PMC3228434.
    33. Wang Y, Rovira M, Yusuff S, Parsons M. Genetic inducible fate mapping in larval zebrafish reveals origins of adult insulin-producing ß-cells. Development. 2011 Feb; 138(4):609-17. PMID: 21208992; PMCID: PMC3026409.
    34. Williams PR, Suzuki SC, Yoshimatsu T, Lawrence OT, Waldron SJ, Parsons M, Nonet ML, Wong RO. In vivo development of outer retinal synapses in the absence of glial contact. J Neurosci. 2010 Sep 08; 30(36):11951-61. PMID: 20826659; PMCID: PMC2946228.
    35. Kani S, Bae YK, Shimizu T, Tanabe K, Satou C, Parsons M, Scott E, Higashijima S, Hibi M. Proneural gene-linked neurogenesis in zebrafish cerebellum. Dev Biol. 2010 Jul 01; 343(1-2):1-17. PMID: 20388506.
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    36. Montgomery JE, Parsons M, Hyde DR. A novel model of retinal ablation demonstrates that the extent of rod cell death regulates the origin of the regenerated zebrafish rod photoreceptors. J Comp Neurol. 2010 Mar 15; 518(6):800-14. PMID: 20058308; PMCID: PMC3656417.
    37. Lad HV, Liu L, Paya-Cano JL, Parsons M, Kember R, Fernandes C, Schalkwyk LC. Behavioural battery testing: evaluation and behavioural outcomes in 8 inbred mouse strains. Physiol Behav. 2010 Mar 03; 99(3):301-16. PMID: 19931548.
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    38. Quwailid MM, Parsons M, Denny P. Report on the 22nd International Mammalian Genome Conference. Mamm Genome. 2009 Nov 20. PMID: 19936831.
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    39. Parsons M, Pisharath H, Yusuff S, Moore JC, Siekmann AF, Lawson N, Leach SD. Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas. Mech Dev. 2009 Oct; 126(10):898-912. PMID: 19595765; PMCID: PMC3640481.
    40. Moss JB, Koustubhan P, Greenman M, Parsons M, Walter I, Moss LG. Regeneration of the pancreas in adult zebrafish. Diabetes. 2009 Aug; 58(8):1844-51. PMID: 19491207; PMCID: PMC2712797.
    41. Nolan PM, Parsons M. Clocks go forward: progress in the molecular genetic analysis of rhythmic behaviour. Mamm Genome. 2009 Feb; 20(2):67-70. PMID: 19145460.
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    42. Pisharath H, Parsons M. Nitroreductase-mediated cell ablation in transgenic zebrafish embryos. Methods Mol Biol. 2009; 546:133-43. PMID: 19378102.
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    43. Parsons M, Grimm CH, Paya-Cano JL, Sugden K, Nietfeld W, Lehrach H, Schalkwyk LC. Using hippocampal microRNA expression differences between mouse inbred strains to characterise miRNA function. Mamm Genome. 2008 Aug; 19(7-8):552-60. PMID: 18594913; PMCID: PMC2755775.
    44. Halpern ME, Rhee J, Goll MG, Akitake CM, Parsons M, Leach SD. Gal4/UAS transgenic tools and their application to zebrafish. Zebrafish. 2008; 5(2):97-110. PMID: 18554173.
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    45. Parsons M, Mata I, Beperet M, Iribarren-Iriso F, Arroyo B, Sainz R, Arranz MJ, Kerwin R. A dopamine D2 receptor gene-related polymorphism is associated with schizophrenia in a Spanish population isolate. Psychiatr Genet. 2007 Jun; 17(3):159-63. PMID: 17417059.
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    46. Davison JM, Akitake CM, Goll MG, Rhee JM, Gosse N, Baier H, Halpern ME, Leach SD, Parsons M. Transactivation from Gal4-VP16 transgenic insertions for tissue-specific cell labeling and ablation in zebrafish. Dev Biol. 2007 Apr 15; 304(2):811-24. PMID: 17335798; PMCID: PMC3470427.
    47. Pisharath H, Rhee JM, Swanson MA, Leach SD, Parsons M. Targeted ablation of beta cells in the embryonic zebrafish pancreas using E. coli nitroreductase. Mech Dev. 2007 Mar; 124(3):218-29. PMID: 17223324; PMCID: PMC2583263.
    48. Pollard SM, Parsons M, Kamei M, Kettleborough RN, Thomas KA, Pham VN, Bae MK, Scott A, Weinstein BM, Stemple DL. Essential and overlapping roles for laminin alpha chains in notochord and blood vessel formation. Dev Biol. 2006 Jan 01; 289(1):64-76. PMID: 16321372.
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    49. Scheid MP, Parsons M, Woodgett JR. Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation. Mol Cell Biol. 2005 Mar; 25(6):2347-63. PMID: 15743829; PMCID: PMC1061613.
    50. Coutinho P, Parsons M, Thomas KA, Hirst EM, Saúde L, Campos I, Williams PH, Stemple DL. Differential requirements for COPI transport during vertebrate early development. Dev Cell. 2004 Oct; 7(4):547-58. PMID: 15469843.
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    51. Parsons M, D'Souza UM, Arranz MJ, Kerwin RW, Makoff AJ. The -1438A/G polymorphism in the 5-hydroxytryptamine type 2A receptor gene affects promoter activity. Biol Psychiatry. 2004 Sep 15; 56(6):406-10. PMID: 15364038.
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    52. Feldman B, Concha ML, Saúde L, Parsons M, Adams RJ, Wilson SW, Stemple DL. Lefty antagonism of Squint is essential for normal gastrulation. Curr Biol. 2002 Dec 23; 12(24):2129-35. PMID: 12498688.
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    53. Jones RG, Elford AR, Parsons M, Wu L, Krawczyk CM, Yeh WC, Hakem R, Rottapel R, Woodgett JR, Ohashi PS. CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly. J Exp Med. 2002 Aug 05; 196(3):335-48. PMID: 12163562; PMCID: PMC2193932.
    54. Parsons M, Campos I, Hirst EM, Stemple DL. Removal of dystroglycan causes severe muscular dystrophy in zebrafish embryos. Development. 2002 Jul; 129(14):3505-12. PMID: 12091319.
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    55. Parsons M, Pollard SM, Saúde L, Feldman B, Coutinho P, Hirst EM, Stemple DL. Zebrafish mutants identify an essential role for laminins in notochord formation. Development. 2002 Jul; 129(13):3137-46. PMID: 12070089.
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