Michael J. Parsons

Title(s)Associate Professor, Developmental & Cell Biology
SchoolSchool of Biological Sciences
Address4361 Natural Sciences II
Zot 2305
Irvine CA 92697
Phone(949) 824-8728
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    Collapse Research 
    Collapse research activities and funding
    High-Throughput Screen For FDA Approved Drugs That Amplify Beta-Cell Mass In Vivo
    NIH RC4DK090816Sep 30, 2010 - Aug 31, 2013
    Role: Co-Principal Investigator
    Transgenic tools for Gal4 regulated gene expression in zebrafish
    NIH R01HD058530Aug 1, 2008 - May 31, 2013
    Role: Co-Principal Investigator
    Characterizing the Role of Pancreatic Progenitors in Regeneration
    NIH R01DK080730Apr 1, 2008 - May 31, 2022
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Generation and application of endogenously floxed alleles for cell-specific knockout in zebrafish. Dev Cell. 2023 Nov 20; 58(22):2614-2626.e7. Shin M, Yin HM, Shih YH, Nozaki T, Portman D, Toles B, Kolb A, Luk K, Isogai S, Ishida K, Hanasaka T, Parsons MJ, Wolfe SA, Burns CE, Burns CG, Lawson ND. PMID: 37633272; PMCID: PMC10840978.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    2. An inducible model of chronic hyperglycemia. Dis Model Mech. 2023 08 01; 16(8). Tucker TR, Knitter CA, Khoury DM, Eshghi S, Tran S, Sharrock AV, Wiles TJ, Ackerley DF, Mumm JS, Parsons MJ. PMID: 37401381; PMCID: PMC10417516.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    3. Elevated glycolysis imparts functional ability to CD8+ T cells in HIV infection. Life Sci Alliance. 2021 11; 4(11). Rahman AN, Liu J, Mujib S, Kidane S, Ali A, Szep S, Han C, Bonner P, Parsons M, Benko E, Kovacs C, Yue FY, Ostrowski M. PMID: 34548381; PMCID: PMC8473722.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    4. SOX9 modulates cancer biomarker and cilia genes in pancreatic cancer. Hum Mol Genet. 2021 04 30; 30(6):485-499. Edelman HE, McClymont SA, Tucker TR, Pineda S, Beer RL, McCallion AS, Parsons MJ. PMID: 33693707; PMCID: PMC8101357.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    5. Attenuating the Epidermal Growth Factor Receptor-Extracellular Signal-Regulated Kinase-Sex-Determining Region Y-Box 9 Axis Promotes Liver Progenitor Cell-Mediated Liver Regeneration in Zebrafish. Hepatology. 2021 04; 73(4):1494-1508. So J, Kim M, Lee SH, Ko S, Lee DA, Park H, Azuma M, Parsons MJ, Prober D, Shin D. PMID: 32602149; PMCID: PMC7769917.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    6. Endoderm Jagged induces liver and pancreas duct lineage in zebrafish. Nat Commun. 2017 10 03; 8(1):769. Zhang D, Gates KP, Barske L, Wang G, Lancman JJ, Zeng XI, Groff M, Wang K, Parsons MJ, Crump JG, Dong PDS. PMID: 28974684; PMCID: PMC5626745.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    7. Sox9b is a mediator of retinoic acid signaling restricting endocrine progenitor differentiation. Dev Biol. 2016 10 01; 418(1):28-39. Huang W, Beer RL, Delaspre F, Wang G, Edelman HE, Park H, Azuma M, Parsons MJ. PMID: 27565026; PMCID: PMC5031550.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    8. Gfap-positive radial glial cells are an essential progenitor population for later-born neurons and glia in the zebrafish spinal cord. Glia. 2016 07; 64(7):1170-89. Johnson K, Barragan J, Bashiruddin S, Smith CJ, Tyrrell C, Parsons MJ, Doris R, Kucenas S, Downes GB, Velez CM, Schneider C, Sakai C, Pathak N, Anderson K, Stein R, Devoto SH, Mumm JS, Barresi MJ. PMID: 27100776; PMCID: PMC4918407.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    9. Centroacinar cells: At the center of pancreas regeneration. Dev Biol. 2016 May 01; 413(1):8-15. Beer RL, Parsons MJ, Rovira M. PMID: 26963675; PMCID: PMC4834238.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    10. First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass. Elife. 2015 Jul 28; 4. Wang G, Rajpurohit SK, Delaspre F, Walker SL, White DT, Ceasrine A, Kuruvilla R, Li RJ, Shim JS, Liu JO, Parsons MJ, Mumm JS. PMID: 26218223; PMCID: PMC4534842.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    11. Centroacinar Cells Are Progenitors That Contribute to Endocrine Pancreas Regeneration. Diabetes. 2015 Oct; 64(10):3499-509. Delaspre F, Beer RL, Rovira M, Huang W, Wang G, Gee S, Vitery Mdel C, Wheelan SJ, Parsons MJ. PMID: 26153247; PMCID: PMC4587647.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    12. Fate mapping of ptf1a-expressing cells during pancreatic organogenesis and regeneration in zebrafish. Dev Dyn. 2015 Jun; 244(6):724-35. Wang YJ, Park JT, Parsons MJ, Leach SD. PMID: 25773748; PMCID: PMC4838417.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    13. Carbamate nerve agent prophylatics exhibit distinct toxicological effects in the zebrafish embryo model. Neurotoxicol Teratol. 2015 Jul-Aug; 50:1-10. Fischer A, Wolman M, Granato M, Parsons M, McCallion AS, Proescher J, English E. PMID: 25968237.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    14. Retinoic acid plays an evolutionarily conserved and biphasic role in pancreas development. Dev Biol. 2014 Oct 01; 394(1):83-93. Huang W, Wang G, Delaspre F, Vitery Mdel C, Beer RL, Parsons MJ. PMID: 25127993; PMCID: PMC4623430.
      View in: PubMed   Mentions: 19     Fields:    
    15. Differential in vivo tumorigenicity of diverse KRAS mutations in vertebrate pancreas: A comprehensive survey. Oncogene. 2015 May 21; 34(21):2801-6. Park JT, Johnson N, Liu S, Levesque M, Wang YJ, Ho H, Huso D, Maitra A, Parsons MJ, Prescott JD, Leach SD. PMID: 25065594; PMCID: PMC4836617.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    16. Distinct Notch signaling outputs pattern the developing arterial system. Development. 2014 Apr; 141(7):1544-52. Quillien A, Moore JC, Shin M, Siekmann AF, Smith T, Pan L, Moens CB, Parsons MJ, Lawson ND. PMID: 24598161; PMCID: PMC4074308.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    17. Aldh1-expressing endocrine progenitor cells regulate secondary islet formation in larval zebrafish pancreas. PLoS One. 2013; 8(9):e74350. Matsuda H, Parsons MJ, Leach SD. PMID: 24147152; PMCID: PMC3798260.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    18. Adoption of the Q transcriptional regulatory system for zebrafish transgenesis. Methods. 2014 Apr 01; 66(3):433-40. Subedi A, Macurak M, Gee ST, Monge E, Goll MG, Potter CJ, Parsons MJ, Halpern ME. PMID: 23792917; PMCID: PMC3883888.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    19. Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development. Development. 2012 Sep; 139(17):3232-41. Provost E, Wehner KA, Zhong X, Ashar F, Nguyen E, Green R, Parsons MJ, Leach SD. PMID: 22872088; PMCID: PMC3413166.
      View in: PubMed   Mentions: 50     Fields:    
    20. Zebrafish sox9b is crucial for hepatopancreatic duct development and pancreatic endocrine cell regeneration. Dev Biol. 2012 Jun 15; 366(2):268-78. Manfroid I, Ghaye A, Naye F, Detry N, Palm S, Pan L, Ma TP, Huang W, Rovira M, Martial JA, Parsons MJ, Moens CB, Voz ML, Peers B. PMID: 22537488; PMCID: PMC3364407.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    21. Automated reporter quantification in vivo: high-throughput screening method for reporter-based assays in zebrafish. PLoS One. 2012; 7(1):e29916. Walker SL, Ariga J, Mathias JR, Coothankandaswamy V, Xie X, Distel M, Köster RW, Parsons MJ, Bhalla KN, Saxena MT, Mumm JS. PMID: 22238673; PMCID: PMC3251595.
      View in: PubMed   Mentions: 52     Fields:    Translation:Animals
    22. Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):19264-9. Rovira M, Huang W, Yusuff S, Shim JS, Ferrante AA, Liu JO, Parsons MJ. PMID: 22084084; PMCID: PMC3228434.
      View in: PubMed   Mentions: 52     Fields:    
    23. Genetic inducible fate mapping in larval zebrafish reveals origins of adult insulin-producing β-cells. Development. 2011 Feb; 138(4):609-17. Wang Y, Rovira M, Yusuff S, Parsons MJ. PMID: 21208992; PMCID: PMC3026409.
      View in: PubMed   Mentions: 60     Fields:    
    24. In vivo development of outer retinal synapses in the absence of glial contact. J Neurosci. 2010 Sep 08; 30(36):11951-61. Williams PR, Suzuki SC, Yoshimatsu T, Lawrence OT, Waldron SJ, Parsons MJ, Nonet ML, Wong RO. PMID: 20826659; PMCID: PMC2946228.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    25. Proneural gene-linked neurogenesis in zebrafish cerebellum. Dev Biol. 2010 Jul 01; 343(1-2):1-17. Kani S, Bae YK, Shimizu T, Tanabe K, Satou C, Parsons MJ, Scott E, Higashijima S, Hibi M. PMID: 20388506.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    26. A novel model of retinal ablation demonstrates that the extent of rod cell death regulates the origin of the regenerated zebrafish rod photoreceptors. J Comp Neurol. 2010 Mar 15; 518(6):800-14. Montgomery JE, Parsons MJ, Hyde DR. PMID: 20058308; PMCID: PMC3656417.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    27. Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas. Mech Dev. 2009 Oct; 126(10):898-912. Parsons MJ, Pisharath H, Yusuff S, Moore JC, Siekmann AF, Lawson N, Leach SD. PMID: 19595765; PMCID: PMC3640481.
      View in: PubMed   Mentions: 213     Fields:    Translation:Animals
    28. Regeneration of the pancreas in adult zebrafish. Diabetes. 2009 Aug; 58(8):1844-51. Moss JB, Koustubhan P, Greenman M, Parsons MJ, Walter I, Moss LG. PMID: 19491207; PMCID: PMC2712797.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    29. Nitroreductase-mediated cell ablation in transgenic zebrafish embryos. Methods Mol Biol. 2009; 546:133-43. Pisharath H, Parsons MJ. PMID: 19378102.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    30. Gal4/UAS transgenic tools and their application to zebrafish. Zebrafish. 2008; 5(2):97-110. Halpern ME, Rhee J, Goll MG, Akitake CM, Parsons M, Leach SD. PMID: 18554173; PMCID: PMC6469517.
      View in: PubMed   Mentions: 106     Fields:    Translation:Animals
    31. Transactivation from Gal4-VP16 transgenic insertions for tissue-specific cell labeling and ablation in zebrafish. Dev Biol. 2007 Apr 15; 304(2):811-24. Davison JM, Akitake CM, Goll MG, Rhee JM, Gosse N, Baier H, Halpern ME, Leach SD, Parsons MJ. PMID: 17335798; PMCID: PMC3470427.
      View in: PubMed   Mentions: 210     Fields:    Translation:AnimalsCells
    32. Targeted ablation of beta cells in the embryonic zebrafish pancreas using E. coli nitroreductase. Mech Dev. 2007 Mar; 124(3):218-29. Pisharath H, Rhee JM, Swanson MA, Leach SD, Parsons MJ. PMID: 17223324; PMCID: PMC2583263.
      View in: PubMed   Mentions: 202     Fields:    Translation:AnimalsCells
    33. Essential and overlapping roles for laminin alpha chains in notochord and blood vessel formation. Dev Biol. 2006 Jan 01; 289(1):64-76. Pollard SM, Parsons MJ, Kamei M, Kettleborough RN, Thomas KA, Pham VN, Bae MK, Scott A, Weinstein BM, Stemple DL. PMID: 16321372.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    34. Differential requirements for COPI transport during vertebrate early development. Dev Cell. 2004 Oct; 7(4):547-58. Coutinho P, Parsons MJ, Thomas KA, Hirst EM, Saúde L, Campos I, Williams PH, Stemple DL. PMID: 15469843.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    35. Lefty antagonism of Squint is essential for normal gastrulation. Curr Biol. 2002 Dec 23; 12(24):2129-35. Feldman B, Concha ML, Saúde L, Parsons MJ, Adams RJ, Wilson SW, Stemple DL. PMID: 12498688.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    36. Zebrafish mutants identify an essential role for laminins in notochord formation. Development. 2002 Jul; 129(13):3137-46. Parsons MJ, Pollard SM, Saúde L, Feldman B, Coutinho P, Hirst EM, Stemple DL. PMID: 12070089.
      View in: PubMed   Mentions: 100     Fields:    Translation:Animals
    37. Removal of dystroglycan causes severe muscular dystrophy in zebrafish embryos. Development. 2002 Jul; 129(14):3505-12. Parsons MJ, Campos I, Hirst EM, Stemple DL. PMID: 12091319.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
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