Travis John Wiles

Title(s)Assistant Professor, Molecular Biology & Biochemistry
SchoolSchool of Biological Sciences
AddressIrvine CA 92697
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    Connecting the Spatiotemporal Organization of Gut Bacterial Communities to the Emergence and Spread of Antibiotic Resistance
    NIH DP2AI154420May 5, 2021 - Apr 30, 2026
    Role: Principal Investigator
    Elucidation of Host and Bacterial Factors that Influence Resilience and Robustnes
    NIH F32AI112094Feb 1, 2014 - Jan 31, 2017
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Phollow reveals in situ phage transmission dynamics in the zebrafish gut microbiome at single-virion resolution. Nat Microbiol. 2025 May; 10(5):1067-1083. Ortiz de Ora L, Wiles ET, Zünd M, Bañuelos MS, Haro-Ramirez N, Suder DS, Ujagar N, Ayala-Angulo J, Trinh C, Knitter C, Gonen S, Nicholas DA, Wiles TJ. PMID: 40251446; PMCID: PMC12055606.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    2. The Vibrio type VI secretion system induces intestinal macrophage redistribution and enhanced intestinal motility. mBio. 2025 Jan 08; 16(1):e0241924. Ngo JS, Amitabh P, Sokoloff JG, Trinh C, Wiles TJ, Guillemin K, Parthasarathy R. PMID: 39576112; PMCID: PMC11708011.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    3. Phollow: Visualizing Gut Bacteriophage Transmission within Microbial Communities and Living Animals. bioRxiv. 2024 Jun 13. Ortiz de Ora L, Wiles ET, Zünd M, Bañuelos MS, Haro-Ramirez N, Suder DS, Ujagar N, Angulo JA, Trinh C, Knitter C, Gonen S, Nicholas DA, Wiles TJ. PMID: 38915633; PMCID: PMC11195241.
      View in: PubMed   Mentions:
    4. An inducible model of chronic hyperglycemia. Dis Model Mech. 2023 08 01; 16(8). Tucker TR, Knitter CA, Khoury DM, Eshghi S, Tran S, Sharrock AV, Wiles TJ, Ackerley DF, Mumm JS, Parsons MJ. PMID: 37401381; PMCID: PMC10417516.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    5. Cultivating Healthy Connections: Exploring and Engineering the Microbial Flow That Shapes Microbiomes. mSystems. 2021 Oct 26; 6(5):e0086321. Wiles TJ. PMID: 34609161; PMCID: PMC8547466.
      View in: PubMed   Mentions:    Fields:    
    6. Swimming motility of a gut bacterial symbiont promotes resistance to intestinal expulsion and enhances inflammation. PLoS Biol. 2020 03; 18(3):e3000661. Wiles TJ, Schlomann BH, Wall ES, Betancourt R, Parthasarathy R, Guillemin K. PMID: 32196484; PMCID: PMC7112236.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    7. Patterns of partnership: surveillance and mimicry in host-microbiota mutualisms. Curr Opin Microbiol. 2020 04; 54:87-94. Wiles TJ, Guillemin K. PMID: 32062152.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    8. Sublethal antibiotics collapse gut bacterial populations by enhancing aggregation and expulsion. Proc Natl Acad Sci U S A. 2019 10 22; 116(43):21392-21400. Schlomann BH, Wiles TJ, Wall ES, Guillemin K, Parthasarathy R. PMID: 31591228; PMCID: PMC6815146.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    9. The Other Side of the Coin: What Beneficial Microbes Can Teach Us about Pathogenic Potential. J Mol Biol. 2019 07 26; 431(16):2946-2956. Wiles TJ, Guillemin K. PMID: 31078557.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    10. Bacterial Cohesion Predicts Spatial Distribution in the Larval Zebrafish Intestine. Biophys J. 2018 12 04; 115(11):2271-2277. Schlomann BH, Wiles TJ, Wall ES, Guillemin K, Parthasarathy R. PMID: 30448038; PMCID: PMC6289661.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    11. Modernized Tools for Streamlined Genetic Manipulation and Comparative Study of Wild and Diverse Proteobacterial Lineages. mBio. 2018 10 09; 9(5). Wiles TJ, Wall ES, Schlomann BH, Hay EA, Parthasarathy R, Guillemin K. PMID: 30301859; PMCID: PMC6178617.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    12. The enteric nervous system promotes intestinal health by constraining microbiota composition. PLoS Biol. 2017 02; 15(2):e2000689. Rolig AS, Mittge EK, Ganz J, Troll JV, Melancon E, Wiles TJ, Alligood K, Stephens WZ, Eisen JS, Guillemin K. PMID: 28207737; PMCID: PMC5331947.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    13. Best practices for germ-free derivation and gnotobiotic zebrafish husbandry. Methods Cell Biol. 2017; 138:61-100. Melancon E, Gomez De La Torre Canny S, Sichel S, Kelly M, Wiles TJ, Rawls JF, Eisen JS, Guillemin K. PMID: 28129860; PMCID: PMC5568843.
      View in: PubMed   Mentions: 73     Fields:    Translation:Animals
    14. Host Gut Motility Promotes Competitive Exclusion within a Model Intestinal Microbiota. PLoS Biol. 2016 07; 14(7):e1002517. Wiles TJ, Jemielita M, Baker RP, Schlomann BH, Logan SL, Ganz J, Melancon E, Eisen JS, Guillemin K, Parthasarathy R. PMID: 27458727; PMCID: PMC4961409.
      View in: PubMed   Mentions: 103     Fields:    Translation:AnimalsCells
    15. Strengths and Limitations of Model Systems for the Study of Urinary Tract Infections and Related Pathologies. Microbiol Mol Biol Rev. 2016 Jun; 80(2):351-67. Barber AE, Norton JP, Wiles TJ, Mulvey MA. PMID: 26935136; PMCID: PMC4867371.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    16. Identification of Population Bottlenecks and Colonization Factors during Assembly of Bacterial Communities within the Zebrafish Intestine. mBio. 2015 Oct 27; 6(6):e01163-15. Stephens WZ, Wiles TJ, Martinez ES, Jemielita M, Burns AR, Parthasarathy R, Bohannan BJ, Guillemin K. PMID: 26507229; PMCID: PMC4626852.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    17. Combining quantitative genetic footprinting and trait enrichment analysis to identify fitness determinants of a bacterial pathogen. PLoS Genet. 2013; 9(8):e1003716. Wiles TJ, Norton JP, Russell CW, Dalley BK, Fischer KF, Mulvey MA. PMID: 23990803; PMCID: PMC3749937.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    18. A phyletically rare gene promotes the niche-specific fitness of an E. coli pathogen during bacteremia. PLoS Pathog. 2013 Feb; 9(2):e1003175. Wiles TJ, Norton JP, Smith SN, Lewis AJ, Mobley HL, Casjens SR, Mulvey MA. PMID: 23459509; PMCID: PMC3573123.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    19. The RTX pore-forming toxin α-hemolysin of uropathogenic Escherichia coli: progress and perspectives. Future Microbiol. 2013 Jan; 8(1):73-84. Wiles TJ, Mulvey MA. PMID: 23252494; PMCID: PMC3570152.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    20. The repeat-in-toxin family member TosA mediates adherence of uropathogenic Escherichia coli and survival during bacteremia. Infect Immun. 2012 Feb; 80(2):493-505. Vigil PD, Wiles TJ, Engstrom MD, Prasov L, Mulvey MA, Mobley HL. PMID: 22083710; PMCID: PMC3264304.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    21. Use of zebrafish to probe the divergent virulence potentials and toxin requirements of extraintestinal pathogenic Escherichia coli. PLoS Pathog. 2009 Dec; 5(12):e1000697. Wiles TJ, Bower JM, Redd MJ, Mulvey MA. PMID: 20019794; PMCID: PMC2785880.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    22. Origins and virulence mechanisms of uropathogenic Escherichia coli. Exp Mol Pathol. 2008 Aug; 85(1):11-9. Wiles TJ, Kulesus RR, Mulvey MA. PMID: 18482721; PMCID: PMC2595135.
      View in: PubMed   Mentions: 225     Fields:    
    23. Inactivation of host Akt/protein kinase B signaling by bacterial pore-forming toxins. Mol Biol Cell. 2008 Apr; 19(4):1427-38. Wiles TJ, Dhakal BK, Eto DS, Mulvey MA. PMID: 18234841; PMCID: PMC2291440.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
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