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John F. Guzowski

Title(s)Associate Professor, Neurobiology & Behavior
Phone(949) 824-0259, 0261
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    Collapse Research 
    Collapse Research Activities and Funding
    Cytokines, Synapses, Neural Circuits and Cognition
    NIH/NIMH R01MH082930Aug 25, 2009 - May 31, 2013
    Role: Principal Investigator
    Memory Consolidation: Hippocampus &Gene Expression
    NIH/NIMH R01MH060123Apr 15, 2000 - Feb 28, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lomeli N, Di K, Czerniawski J, Guzowski JF, Bota DA. Cisplatin-induced mitochondrial dysfunction is associated with impaired cognitive function in rats. Free Radic Biol Med. 2017 01; 102:274-286. PMID: 27908784.
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    2. Witharana WK, Cardiff J, Chawla MK, Xie JY, Alme CB, Eckert M, Lapointe V, Demchuk A, Maurer AP, Trivedi V, Sutherland RJ, Guzowski JF, Barnes CA, McNaughton BL. Nonuniform allocation of hippocampal neurons to place fields across all hippocampal subfields. Hippocampus. 2016 10; 26(10):1328-44. PMID: 27273259.
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    3. Pevzner A, Guzowski JF. Immediate-early gene transcriptional activation in hippocampus CA1 and CA3 does not accurately reflect rapid, pattern completion-based retrieval of context memory. Learn Mem. 2014 Jan; 22(1):1-5. PMID: 25512571.
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    4. Czerniawski J, Miyashita T, Lewandowski G, Guzowski JF. Systemic lipopolysaccharide administration impairs retrieval of context-object discrimination, but not spatial, memory: Evidence for selective disruption of specific hippocampus-dependent memory functions during acute neuroinflammation. Brain Behav Immun. 2015 Feb; 44:159-66. PMID: 25451612.
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    5. Alaghband Y, O'Dell SJ, Azarnia S, Khalaj AJ, Guzowski JF, Marshall JF. Retrieval-induced NMDA receptor-dependent Arc expression in two models of cocaine-cue memory. Neurobiol Learn Mem. 2014 Dec; 116:79-89. PMID: 25225165.
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    6. Czerniawski J, Guzowski JF. Acute neuroinflammation impairs context discrimination memory and disrupts pattern separation processes in hippocampus. J Neurosci. 2014 Sep 10; 34(37):12470-80. PMID: 25209285.
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    7. Pevzner A, Miyashita T, Schiffman AJ, Guzowski JF. Temporal dynamics of Arc gene induction in hippocampus: relationship to context memory formation. Neurobiol Learn Mem. 2012 Mar; 97(3):313-20. PMID: 22390855.
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    8. Kubik S, Miyashita T, Kubik-Zahorodna A, Guzowski JF. Loss of activity-dependent Arc gene expression in the retrosplenial cortex after hippocampal inactivation: interaction in a higher-order memory circuit. Neurobiol Learn Mem. 2012 Jan; 97(1):124-31. PMID: 22100445.
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    9. Miyashita T, Kubik S, Haghighi N, Steward O, Guzowski JF. Rapid activation of plasticity-associated gene transcription in hippocampal neurons provides a mechanism for encoding of one-trial experience. J Neurosci. 2009 Jan 28; 29(4):898-906. PMID: 19176799.
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    10. Bramham CR, Worley PF, Moore MJ, Guzowski JF. The immediate early gene arc/arg3.1: regulation, mechanisms, and function. J Neurosci. 2008 Nov 12; 28(46):11760-7. PMID: 19005037.
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    11. Alkire MT, Guzowski JF. Hypothesis: suppression of memory protein formation underlies anesthetic-induced amnesia. Anesthesiology. 2008 Nov; 109(5):768-70. PMID: 18946284.
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    12. Kubik S, Miyashita T, Guzowski JF. Using immediate-early genes to map hippocampal subregional functions. Learn Mem. 2007 Nov; 14(11):758-70. PMID: 18007019.
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    13. Miyashita T, Kubik S, Lewandowski G, Guzowski JF. Networks of neurons, networks of genes: an integrated view of memory consolidation. Neurobiol Learn Mem. 2008 Mar; 89(3):269-84. PMID: 17931913.
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    14. Lin G, Chawla MK, Olson K, Barnes CA, Guzowski JF, Bjornsson C, Shain W, Roysam B. A multi-model approach to simultaneous segmentation and classification of heterogeneous populations of cell nuclei in 3D confocal microscope images. Cytometry A. 2007 Sep; 71(9):724-36. PMID: 17654650.
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    15. Steward O, Huang F, Guzowski JF. A form of perforant path LTP can occur without ERK1/2 phosphorylation or immediate early gene induction. Learn Mem. 2007 Jun; 14(6):433-45. PMID: 17562895.
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    16. Han JH, Kushner SA, Yiu AP, Cole CJ, Matynia A, Brown RA, Neve RL, Guzowski JF, Silva AJ, Josselyn SA. Neuronal competition and selection during memory formation. Science. 2007 Apr 20; 316(5823):457-60. PMID: 17446403.
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    17. Fletcher BR, Baxter MG, Guzowski JF, Shapiro ML, Rapp PR. Selective cholinergic depletion of the hippocampus spares both behaviorally induced Arc transcription and spatial learning and memory. Hippocampus. 2007; 17(3):227-34. PMID: 17286278.
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    18. Sutherland VL, Timlin JA, Nieman LT, Guzowski JF, Chawla MK, Worley PF, Roysam B, McNaughton BL, Sinclair MB, Barnes CA. Advanced imaging of multiple mRNAs in brain tissue using a custom hyperspectral imager and multivariate curve resolution. J Neurosci Methods. 2007 Feb 15; 160(1):144-8. PMID: 17049619.
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    19. Vazdarjanova A, Ramirez-Amaya V, Insel N, Plummer TK, Rosi S, Chowdhury S, Mikhael D, Worley PF, Guzowski JF, Barnes CA. Spatial exploration induces ARC, a plasticity-related immediate-early gene, only in calcium/calmodulin-dependent protein kinase II-positive principal excitatory and inhibitory neurons of the rat forebrain. J Comp Neurol. 2006 Sep 20; 498(3):317-29. PMID: 16871537.
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    20. Tafoya LC, Mameli M, Miyashita T, Guzowski JF, Valenzuela CF, Wilson MC. Expression and function of SNAP-25 as a universal SNARE component in GABAergic neurons. J Neurosci. 2006 Jul 26; 26(30):7826-38. PMID: 16870728.
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    21. Guzowski JF, Miyashita T, Chawla MK, Sanderson J, Maes LI, Houston FP, Lipa P, McNaughton BL, Worley PF, Barnes CA. Recent behavioral history modifies coupling between cell activity and Arc gene transcription in hippocampal CA1 neurons. Proc Natl Acad Sci U S A. 2006 Jan 24; 103(4):1077-82. PMID: 16415163.
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    22. Guzowski JF, Timlin JA, Roysam B, McNaughton BL, Worley PF, Barnes CA. Mapping behaviorally relevant neural circuits with immediate-early gene expression. Curr Opin Neurobiol. 2005 Oct; 15(5):599-606. PMID: 16150584.
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    23. McIntyre CK, Miyashita T, Setlow B, Marjon KD, Steward O, Guzowski JF, McGaugh JL. Memory-influencing intra-basolateral amygdala drug infusions modulate expression of Arc protein in the hippocampus. Proc Natl Acad Sci U S A. 2005 Jul 26; 102(30):10718-23. PMID: 16020527.
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    24. Zhang WP, Guzowski JF, Thomas SA. Mapping neuronal activation and the influence of adrenergic signaling during contextual memory retrieval. Learn Mem. 2005 May-Jun; 12(3):239-47. PMID: 15930502.
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    25. Lin G, Chawla MK, Olson K, Guzowski JF, Barnes CA, Roysam B. Hierarchical, model-based merging of multiple fragments for improved three-dimensional segmentation of nuclei. Cytometry A. 2005; 63(1):20-33. PMID: 15584021.
      View in: PubMed
    26. Chawla MK, Guzowski JF, Ramirez-Amaya V, Lipa P, Hoffman KL, Marriott LK, Worley PF, McNaughton BL, Barnes CA. Sparse, environmentally selective expression of Arc RNA in the upper blade of the rodent fascia dentata by brief spatial experience. Hippocampus. 2005; 15(5):579-86. PMID: 15920719.
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    27. Guzowski JF, Knierim JJ, Moser EI. Ensemble dynamics of hippocampal regions CA3 and CA1. Neuron. 2004 Nov 18; 44(4):581-4. PMID: 15541306.
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    28. Chawla MK, Lin G, Olson K, Vazdarjanova A, Burke SN, McNaughton BL, Worley PF, Guzowski JF, Roysam B, Barnes CA. 3D-catFISH: a system for automated quantitative three-dimensional compartmental analysis of temporal gene transcription activity imaged by fluorescence in situ hybridization. J Neurosci Methods. 2004 Oct 15; 139(1):13-24. PMID: 15351517.
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    29. Vazdarjanova A, Guzowski JF. Differences in hippocampal neuronal population responses to modifications of an environmental context: evidence for distinct, yet complementary, functions of CA3 and CA1 ensembles. J Neurosci. 2004 Jul 21; 24(29):6489-96. PMID: 15269259.
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    30. Dickey CA, Gordon MN, Mason JE, Wilson NJ, Diamond DM, Guzowski JF, Morgan D. Amyloid suppresses induction of genes critical for memory consolidation in APP + PS1 transgenic mice. J Neurochem. 2004 Jan; 88(2):434-42. PMID: 14690531.
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    31. Lin G, Adiga U, Olson K, Guzowski JF, Barnes CA, Roysam B. A hybrid 3D watershed algorithm incorporating gradient cues and object models for automatic segmentation of nuclei in confocal image stacks. Cytometry A. 2003 Nov; 56(1):23-36. PMID: 14566936.
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    32. Vazdarjanova A, McNaughton BL, Barnes CA, Worley PF, Guzowski JF. Experience-dependent coincident expression of the effector immediate-early genes arc and Homer 1a in hippocampal and neocortical neuronal networks. J Neurosci. 2002 Dec 01; 22(23):10067-71. PMID: 12451105.
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    33. Bottai D, Guzowski JF, Schwarz MK, Kang SH, Xiao B, Lanahan A, Worley PF, Seeburg PH. Synaptic activity-induced conversion of intronic to exonic sequence in Homer 1 immediate early gene expression. J Neurosci. 2002 Jan 01; 22(1):167-75. PMID: 11756499.
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    34. Guzowski JF. Insights into immediate-early gene function in hippocampal memory consolidation using antisense oligonucleotide and fluorescent imaging approaches. Hippocampus. 2002; 12(1):86-104. PMID: 11918292.
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    35. Guzowski JF, McNaughton BL, Barnes CA, Worley PF. Imaging neural activity with temporal and cellular resolution using FISH. Curr Opin Neurobiol. 2001 Oct; 11(5):579-84. PMID: 11595491.
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    36. Guzowski JF, Worley PF. Cellular compartment analysis of temporal activity by fluorescence in situ hybridization (catFISH). Curr Protoc Neurosci. 2001 Aug; Chapter 1:Unit 1.8. PMID: 18428454.
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    37. Guzowski JF, Setlow B, Wagner EK, McGaugh JL. Experience-dependent gene expression in the rat hippocampus after spatial learning: a comparison of the immediate-early genes Arc, c-fos, and zif268. J Neurosci. 2001 Jul 15; 21(14):5089-98. PMID: 11438584.
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    38. Redish AD, Battaglia FP, Chawla MK, Ekstrom AD, Gerrard JL, Lipa P, Rosenzweig ES, Worley PF, Guzowski JF, McNaughton BL, Barnes CA. Independence of firing correlates of anatomically proximate hippocampal pyramidal cells. J Neurosci. 2001 Mar 01; 21(5):RC134. PMID: 11222672.
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    39. Guzowski JF, Lyford GL, Stevenson GD, Houston FP, McGaugh JL, Worley PF, Barnes CA. Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory. J Neurosci. 2000 Jun 01; 20(11):3993-4001. PMID: 10818134.
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    40. Guzowski JF, McNaughton BL, Barnes CA, Worley PF. Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles. Nat Neurosci. 1999 Dec; 2(12):1120-4. PMID: 10570490.
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    41. Guzowski JF, McGaugh JL. Antisense oligodeoxynucleotide-mediated disruption of hippocampal cAMP response element binding protein levels impairs consolidation of memory for water maze training. Proc Natl Acad Sci U S A. 1997 Mar 18; 94(6):2693-8. PMID: 9122258.
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    42. Wagner EK, Guzowski JF, Singh J. Transcription of the herpes simplex virus genome during productive and latent infection. Prog Nucleic Acid Res Mol Biol. 1995; 51:123-65. PMID: 7659774.
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    43. Guzowski JF, Singh J, Wagner EK. Transcriptional activation of the herpes simplex virus type 1 UL38 promoter conferred by the cis-acting downstream activation sequence is mediated by a cellular transcription factor. J Virol. 1994 Dec; 68(12):7774-89. PMID: 7966567.
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    44. Guzowski JF, Wagner EK. Mutational analysis of the herpes simplex virus type 1 strict late UL38 promoter/leader reveals two regions critical in transcriptional regulation. J Virol. 1993 Sep; 67(9):5098-108. PMID: 8394438.
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    45. Huang CJ, Goodart SA, Rice MK, Guzowski JF, Wagner EK. Mutational analysis of sequences downstream of the TATA box of the herpes simplex virus type 1 major capsid protein (VP5/UL19) promoter. J Virol. 1993 Sep; 67(9):5109-16. PMID: 8394439.
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    46. Goodart SA, Guzowski JF, Rice MK, Wagner EK. Effect of genomic location on expression of beta-galactosidase mRNA controlled by the herpes simplex virus type 1 UL38 promoter. J Virol. 1992 May; 66(5):2973-81. PMID: 1313912.
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