Guzowski, John F

TitleAssociate Professor
InstitutionUniversity of California, Irvine
DepartmentNeurobiology & Behavior
Address108 Bonney Research Lab
Zot 3800
CA 92697
Phone(949) 824-0259, 0261
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    Collapse Research 
    Collapse Research Activities and Funding
    Cytokines, Synapses, Neural Circuits and Cognition
    NIH/NIMH R01MH082930Aug 25, 2009 - May 31, 2013
    Role: Principal Investigator
    Memory Consolidation: Hippocampus &Gene Expression
    NIH/NIMH R01MH060123Apr 15, 2000 - Feb 28, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lomeli N, Di K, Czerniawski J, Guzowski J, Bota DA. Cisplatin-induced mitochondrial dysfunction is associated with impaired cognitive function in rats. Free Radic Biol Med. 2017 01; 102:274-286. PMID: 27908784.
      View in: PubMed
    2. Pevzner A, Guzowski J. Immediate-early gene transcriptional activation in hippocampus CA1 and CA3 does not accurately reflect rapid, pattern completion-based retrieval of context memory. Learn Mem. 2014 Jan; 22(1):1-5. PMID: 25512571; PMCID: PMC4274330.
    3. Czerniawski J, Miyashita T, Lewandowski G, Guzowski J. Systemic lipopolysaccharide administration impairs retrieval of context-object discrimination, but not spatial, memory: Evidence for selective disruption of specific hippocampus-dependent memory functions during acute neuroinflammation. Brain Behav Immun. 2015 Feb; 44:159-66. PMID: 25451612; PMCID: PMC4358899.
    4. Alaghband Y, O'Dell SJ, Azarnia S, Khalaj AJ, Guzowski J, Marshall JF. Retrieval-induced NMDA receptor-dependent Arc expression in two models of cocaine-cue memory. Neurobiol Learn Mem. 2014 Dec; 116:79-89. PMID: 25225165; PMCID: PMC4262590.
    5. Czerniawski J, Guzowski J. Acute neuroinflammation impairs context discrimination memory and disrupts pattern separation processes in hippocampus. J Neurosci. 2014 Sep 10; 34(37):12470-80. PMID: 25209285; PMCID: PMC4160778.
    6. Pevzner A, Miyashita T, Schiffman AJ, Guzowski J. Temporal dynamics of Arc gene induction in hippocampus: relationship to context memory formation. Neurobiol Learn Mem. 2012 Mar; 97(3):313-20. PMID: 22390855.
      View in: PubMed
    7. Kubik S, Miyashita T, Kubik-Zahorodna A, Guzowski J. Loss of activity-dependent Arc gene expression in the retrosplenial cortex after hippocampal inactivation: interaction in a higher-order memory circuit. Neurobiol Learn Mem. 2012 Jan; 97(1):124-31. PMID: 22100445.
      View in: PubMed
    8. Miyashita T, Kubik S, Haghighi N, Steward O, Guzowski J. Rapid activation of plasticity-associated gene transcription in hippocampal neurons provides a mechanism for encoding of one-trial experience. J Neurosci. 2009 Jan 28; 29(4):898-906. PMID: 19176799; PMCID: PMC2749324.
    9. Bramham CR, Worley PF, Moore MJ, Guzowski J. The immediate early gene arc/arg3.1: regulation, mechanisms, and function. J Neurosci. 2008 Nov 12; 28(46):11760-7. PMID: 19005037; PMCID: PMC2615463.
    10. Alkire MT, Guzowski J. Hypothesis: suppression of memory protein formation underlies anesthetic-induced amnesia. Anesthesiology. 2008 Nov; 109(5):768-70. PMID: 18946284; PMCID: PMC2699485.
    11. Kubik S, Miyashita T, Guzowski J. Using immediate-early genes to map hippocampal subregional functions. Learn Mem. 2007 Nov; 14(11):758-70. PMID: 18007019.
      View in: PubMed
    12. Miyashita T, Kubik S, Lewandowski G, Guzowski J. Networks of neurons, networks of genes: an integrated view of memory consolidation. Neurobiol Learn Mem. 2008 Mar; 89(3):269-84. PMID: 17931913; PMCID: PMC2293276.
    13. Lin G, Chawla MK, Olson K, Barnes CA, Guzowski J, Bjornsson C, Shain W, Roysam B. A multi-model approach to simultaneous segmentation and classification of heterogeneous populations of cell nuclei in 3D confocal microscope images. Cytometry A. 2007 Sep; 71(9):724-36. PMID: 17654650.
      View in: PubMed
    14. Steward O, Huang F, Guzowski J. A form of perforant path LTP can occur without ERK1/2 phosphorylation or immediate early gene induction. Learn Mem. 2007 Jun; 14(6):433-45. PMID: 17562895; PMCID: PMC1896093.
    15. Han JH, Kushner SA, Yiu AP, Cole CJ, Matynia A, Brown RA, Neve RL, Guzowski J, Silva AJ, Josselyn SA. Neuronal competition and selection during memory formation. Science. 2007 Apr 20; 316(5823):457-60. PMID: 17446403.
      View in: PubMed
    16. Fletcher BR, Baxter MG, Guzowski J, Shapiro ML, Rapp PR. Selective cholinergic depletion of the hippocampus spares both behaviorally induced Arc transcription and spatial learning and memory. Hippocampus. 2007; 17(3):227-34. PMID: 17286278.
      View in: PubMed
    17. Sutherland VL, Timlin JA, Nieman LT, Guzowski J, Chawla MK, Worley PF, Roysam B, McNaughton BL, Sinclair MB, Barnes CA. Advanced imaging of multiple mRNAs in brain tissue using a custom hyperspectral imager and multivariate curve resolution. J Neurosci Methods. 2007 Feb 15; 160(1):144-8. PMID: 17049619; PMCID: PMC1815393.
    18. Vazdarjanova A, Ramirez-Amaya V, Insel N, Plummer TK, Rosi S, Chowdhury S, Mikhael D, Worley PF, Guzowski J, Barnes CA. Spatial exploration induces ARC, a plasticity-related immediate-early gene, only in calcium/calmodulin-dependent protein kinase II-positive principal excitatory and inhibitory neurons of the rat forebrain. J Comp Neurol. 2006 Sep 20; 498(3):317-29. PMID: 16871537.
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    19. Tafoya LC, Mameli M, Miyashita T, Guzowski J, Valenzuela CF, Wilson MC. Expression and function of SNAP-25 as a universal SNARE component in GABAergic neurons. J Neurosci. 2006 Jul 26; 26(30):7826-38. PMID: 16870728.
      View in: PubMed
    20. Guzowski J, Miyashita T, Chawla MK, Sanderson J, Maes LI, Houston FP, Lipa P, McNaughton BL, Worley PF, Barnes CA. Recent behavioral history modifies coupling between cell activity and Arc gene transcription in hippocampal CA1 neurons. Proc Natl Acad Sci U S A. 2006 Jan 24; 103(4):1077-82. PMID: 16415163; PMCID: PMC1347968.
    21. Guzowski J, Timlin JA, Roysam B, McNaughton BL, Worley PF, Barnes CA. Mapping behaviorally relevant neural circuits with immediate-early gene expression. Curr Opin Neurobiol. 2005 Oct; 15(5):599-606. PMID: 16150584.
      View in: PubMed
    22. McIntyre CK, Miyashita T, Setlow B, Marjon KD, Steward O, Guzowski J, McGaugh JL. Memory-influencing intra-basolateral amygdala drug infusions modulate expression of Arc protein in the hippocampus. Proc Natl Acad Sci U S A. 2005 Jul 26; 102(30):10718-23. PMID: 16020527; PMCID: PMC1175582.
    23. Zhang WP, Guzowski J, Thomas SA. Mapping neuronal activation and the influence of adrenergic signaling during contextual memory retrieval. Learn Mem. 2005 May-Jun; 12(3):239-47. PMID: 15930502; PMCID: PMC1142451.
    24. Lin G, Chawla MK, Olson K, Guzowski J, Barnes CA, Roysam B. Hierarchical, model-based merging of multiple fragments for improved three-dimensional segmentation of nuclei. Cytometry A. 2005; 63(1):20-33. PMID: 15584021.
      View in: PubMed
    25. Guzowski J, Knierim JJ, Moser EI. Ensemble dynamics of hippocampal regions CA3 and CA1. Neuron. 2004 Nov 18; 44(4):581-4. PMID: 15541306.
      View in: PubMed
    26. Chawla MK, Lin G, Olson K, Vazdarjanova A, Burke SN, McNaughton BL, Worley PF, Guzowski J, Roysam B, Barnes CA. 3D-catFISH: a system for automated quantitative three-dimensional compartmental analysis of temporal gene transcription activity imaged by fluorescence in situ hybridization. J Neurosci Methods. 2004 Oct 15; 139(1):13-24. PMID: 15351517.
      View in: PubMed
    27. Vazdarjanova A, Guzowski J. Differences in hippocampal neuronal population responses to modifications of an environmental context: evidence for distinct, yet complementary, functions of CA3 and CA1 ensembles. J Neurosci. 2004 Jul 21; 24(29):6489-96. PMID: 15269259.
      View in: PubMed
    28. Dickey CA, Gordon MN, Mason JE, Wilson NJ, Diamond DM, Guzowski J, Morgan D. Amyloid suppresses induction of genes critical for memory consolidation in APP + PS1 transgenic mice. J Neurochem. 2004 Jan; 88(2):434-42. PMID: 14690531.
      View in: PubMed
    29. Lin G, Adiga U, Olson K, Guzowski J, Barnes CA, Roysam B. A hybrid 3D watershed algorithm incorporating gradient cues and object models for automatic segmentation of nuclei in confocal image stacks. Cytometry A. 2003 Nov; 56(1):23-36. PMID: 14566936.
      View in: PubMed
    30. Vazdarjanova A, McNaughton BL, Barnes CA, Worley PF, Guzowski J. Experience-dependent coincident expression of the effector immediate-early genes arc and Homer 1a in hippocampal and neocortical neuronal networks. J Neurosci. 2002 Dec 01; 22(23):10067-71. PMID: 12451105.
      View in: PubMed
    31. Bottai D, Guzowski J, Schwarz MK, Kang SH, Xiao B, Lanahan A, Worley PF, Seeburg PH. Synaptic activity-induced conversion of intronic to exonic sequence in Homer 1 immediate early gene expression. J Neurosci. 2002 Jan 01; 22(1):167-75. PMID: 11756499.
      View in: PubMed
    32. Guzowski J. Insights into immediate-early gene function in hippocampal memory consolidation using antisense oligonucleotide and fluorescent imaging approaches. Hippocampus. 2002; 12(1):86-104. PMID: 11918292.
      View in: PubMed
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