David Butler Hoyt

Title(s)Professor Emeritus, Surgery
Address1001 Health Sciences Road
Irvine CA 92697-3950
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    Collapse Research 
    Collapse Research Activities and Funding
    Resuscitation Outcomes Consortium (ROC) Regional Clinical Center, San Diego
    NIH U01HL077908Sep 1, 2004 - Dec 31, 2016
    Role: Co-Principal Investigator
    Hemorrhagic Shock and Pancreatic Enzyme Products
    NIH R01HL076180Mar 1, 2004 - Feb 28, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Evidence Review for the American College of Surgeons Quality Verification Part I: Building Quality and Safety Resources and Infrastructure. J Am Coll Surg. 2020 11; 231(5):557-569.e1. Hu QL, Fischer CP, Wescott AB, Maggard-Gibbons M, Hoyt DB, Ko CY. PMID: 33002588.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. The anatomy of an article: Methods and results. J Trauma Acute Care Surg. 2017 09; 83(3):543-550. Sauaia A, Moore EE, Crebs J, Maier R, Hoyt DB, Shackford SR. PMID: 28463937.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    3. Prehospital Resuscitation of Traumatic Hemorrhagic Shock with Hypertonic Solutions Worsens Hypocoagulation and Hyperfibrinolysis. Shock. 2015 Jul; 44(1):25-31. Delano MJ, Rizoli SB, Rhind SG, Cuschieri J, Junger W, Baker AJ, Dubick MA, Hoyt DB, Bulger EM. PMID: 25784523.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCTClinical Trials
    4. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. JAMA. 2015 Feb 03; 313(5):471-82. Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, Cohen MJ, Cotton BA, Fabian TC, Inaba K, Kerby JD, Muskat P, O'Keeffe T, Rizoli S, Robinson BR, Scalea TM, Schreiber MA, Stein DM, Weinberg JA, Callum JL, Hess JR, Matijevic N, Miller CN, Pittet JF, Hoyt DB, Pearson GD, Leroux B, van Belle G, PROPPR Study Group . PMID: 25647203.
      View in: PubMed   Mentions: 289     Fields:    Translation:HumansCellsCTClinical Trials
    5. The anatomy of an article: title, abstract, and introduction. J Trauma Acute Care Surg. 2014 May; 76(5):1322-7. Sauaia A, Moore EE, Crebs JL, Maier RV, Hoyt DB, Shackford SR. PMID: 24747468.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    6. Current opinion on catheter-based hemorrhage control in trauma patients. J Trauma Acute Care Surg. 2014 Mar; 76(3):888-93. Holcomb JB, Fox EE, Scalea TM, Napolitano LM, Albarado R, Gill B, Dunkin BJ, Kirkpatrick AW, Cotton BA, Inaba K, DuBose JJ, Cohen AM, Azizzadeh A, Brenner M, Cohen MJ, Wade CE, Lumsden AB, Andrassy R, Rhee PM, Bass BL, Mattox KL, Britt LD, Eastman AB, Hoyt DB, Rasmussen TE, Catheter-Based Hemorrhage Control Study Group . PMID: 24553566.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    7. Preparing senior medical students for surgical internship: the value of a half-day intervention. Am Surg. 2014 Jan; 80(1):102-4. Mowlds DS, Patel MS, Khalsa B, Foe-Parker JE, Salibian AA, Rama A, Jafari F, Whealon MD, Hoyt DB, Stamos MJ, Endres JE, Smith BR. PMID: 24401528.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Prehospital hypertonic saline resuscitation attenuates the activation and promotes apoptosis of neutrophils in patients with severe traumatic brain injury. Shock. 2013 Nov; 40(5):366-74. Junger WG, Rhind SG, Rizoli SB, Cuschieri J, Baker AJ, Shek PN, Hoyt DB, Bulger EM. PMID: 24088993.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    9. Early intervention to promote medical student interest in surgery and the surgical subspecialties. J Surg Educ. 2013 Jan-Feb; 70(1):81-6. Patel MS, Mowlds DS, Khalsa B, Foe-Parker JE, Rama A, Jafari F, Whealon MD, Salibian A, Hoyt DB, Stamos MJ, Endres JE, Smith BR. PMID: 23337675.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    10. Penetrating oesophageal injury: a contemporary analysis of the National Trauma Data Bank. Injury. 2013 Jan; 44(1):48-55. Patel MS, Malinoski DJ, Zhou L, Neal ML, Hoyt DB. PMID: 22209382.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    11. Risk factors for venous thromboembolism in critically ill trauma patients who cannot receive chemical prophylaxis. Injury. 2013 Jan; 44(1):80-5. Malinoski D, Ewing T, Patel MS, Jafari F, Sloane B, Nguyen B, Barrios C, Kong A, Cinat M, Dolich M, Lekawa M, Hoyt DB. PMID: 22047757.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansPHPublic Health
    12. Implementation of a cost-saving algorithm for pelvic radiographs in blunt trauma patients. J Trauma. 2011 Sep; 71(3):582-4. Barleben A, Jafari F, Rose J, Dolich M, Malinoski D, Lekawa M, Hoyt D, Cinat M. PMID: 21908996.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    13. Laser Doppler imaging for early detection of hemorrhage. J Trauma. 2011 Aug; 71(2):401-6. Kaiser ML, Kong AP, Steward E, Whealon M, Patel M, Hoyt DB, Cinat ME. PMID: 21825944.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    14. State of the art of fluid resuscitation 2010: prehospital and immediate transition to the hospital. J Trauma. 2011 May; 70(5 Suppl):S2-10. McSwain NE, Champion HR, Fabian TC, Hoyt DB, Wade CE, Eastridge BJ, Proctor KG, Rasmussen TE, Roussel RR, Butler FK, Holcomb JB, Schreiber MA, Shackford SR, Blackbourne LH. PMID: 21841563.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    15. Risk factors for traumatic injury findings on thoracic computed tomography among patients with blunt trauma having a normal chest radiograph. Arch Surg. 2011 Apr; 146(4):459-63. Kaiser ML, Whealon MD, Barrios C, Dobson SC, Malinoski DJ, Dolich MO, Lekawa ME, Hoyt DB, Cinat ME. PMID: 21502456.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. Postinjury depression is a serious complication in adolescents after major trauma: injury severity and injury-event factors predict depression and long-term quality of life deficits. J Trauma. 2011 Apr; 70(4):923-30. Han PP, Holbrook TL, Sise MJ, Sack DI, Sise CB, Hoyt DB, Coimbra R, Potenza B, Anderson JP. PMID: 21610397.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    17. The impact of select chronic diseases on outcomes after trauma: a study from the National Trauma Data Bank. J Am Coll Surg. 2011 Jan; 212(1):96-104. Patel MS, Malinoski DJ, Nguyen XM, Hoyt DB. PMID: 21184957.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    18. The clinical significance of occult thoracic injury in blunt trauma patients. Am Surg. 2010 Oct; 76(10):1063-6. Kaiser M, Whealon M, Barrios C, Dobson S, Malinoski D, Dolich M, Lekawa M, Hoyt D, Cinat M. PMID: 21105610.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    19. Severe traumatic injury: regional variation in incidence and outcome. Ann Surg. 2010 Jul; 252(1):149-57. Minei JP, Schmicker RH, Kerby JD, Stiell IG, Schreiber MA, Bulger E, Tisherman S, Hoyt DB, Nichol G, Resuscitation Outcome Consortium Investigators . PMID: 20531005.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    20. Inhibition of intraluminal pancreatic enzymes with nafamostat mesilate improves clinical outcomes after hemorrhagic shock in swine. J Trauma. 2010 May; 68(5):1078-83. Kim HD, Malinoski DJ, Borazjani B, Patel MS, Chen J, Slone J, Nguyen XM, Steward E, Schmid-Schonbein GW, Hoyt DB. PMID: 20453762.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    21. Standard prophylactic enoxaparin dosing leads to inadequate anti-Xa levels and increased deep venous thrombosis rates in critically ill trauma and surgical patients. J Trauma. 2010 Apr; 68(4):874-80. Malinoski D, Jafari F, Ewing T, Ardary C, Conniff H, Baje M, Kong A, Lekawa ME, Dolich MO, Cinat ME, Barrios C, Hoyt DB. PMID: 20386282.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    22. Educational initiative on critical bleeding in trauma: Chicago, July 11-13, 2008. J Trauma. 2010 Jan; 68(1):225-30. Bouillon B, Brohi K, Hess JR, Holcomb JB, Parr MJ, Hoyt DB. PMID: 20065778.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    23. Pancreatic duct: A suitable route to oxygenate tissue during pancreas hypothermic preservation? Transpl Immunol. 2010 Feb; 22(3-4):191-4. Mirbolooki MR, Alexander M, Hoyt DB, Lakey JR. PMID: 19900551.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    24. Utility of thoracic computed tomography after blunt trauma: when is chest radiograph enough? Am Surg. 2009 Oct; 75(10):966-9. Barrios C, Malinoski D, Dolich M, Lekawa M, Hoyt D, Cinat M. PMID: 19886146.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    25. Early predictors of the need for emergent surgery to control hemorrhage in hypotensive trauma patients. Am Surg. 2009 Oct; 75(10):986-90. Kaiser M, Ahearn P, Nguyen XM, Barleben A, Cinat M, Barrios C, Hoyt D, Malinoski D. PMID: 19886150.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    26. Elevated serum pancreatic enzyme levels after hemorrhagic shock predict organ failure and death. J Trauma. 2009 Sep; 67(3):445-9. Malinoski DJ, Hadjizacharia P, Salim A, Kim H, Dolich MO, Cinat M, Barrios C, Lekawa ME, Hoyt DB. PMID: 19741384.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    27. The United States critical illness and injury trials group: an introduction. J Trauma. 2009 Aug; 67(2 Suppl):S159-60. Cobb JP, Cairns CB, Bulger E, Wong HR, Parsons PE, Angus DC, Gentile NT, Hoyt DB, Schwinn DA, Wiener-Kronish JP, Upperman JS. PMID: 19667851.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    28. Successful management of occult pneumothorax without tube thoracostomy despite positive pressure ventilation. Am Surg. 2008 Oct; 74(10):958-61. Barrios C, Tran T, Malinoski D, Lekawa M, Dolich M, Lush S, Hoyt D, Cinat ME. PMID: 18942622.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    29. Management of coagulopathy in the patients with multiple injuries: results from an international survey of clinical practice. J Trauma. 2008 Oct; 65(4):755-64; discussion 764-5. Hoyt DB, Dutton RP, Hauser CJ, Hess JR, Holcomb JB, Kluger Y, Mackway-Jones K, Parr MJ, Rizoli SB, Yukioka T, Bouillon B. PMID: 18849787.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    30. The coagulopathy of trauma: a review of mechanisms. J Trauma. 2008 Oct; 65(4):748-54. Hess JR, Brohi K, Dutton RP, Hauser CJ, Holcomb JB, Kluger Y, Mackway-Jones K, Parr MJ, Rizoli SB, Yukioka T, Hoyt DB, Bouillon B. PMID: 18849786.
      View in: PubMed   Mentions: 184     Fields:    Translation:Humans
    31. Traumatic coagulopathy: where are the good experimental models? J Trauma. 2008 Oct; 65(4):766-71. Parr MJ, Bouillon B, Brohi K, Dutton RP, Hauser CJ, Hess JR, Holcomb JB, Kluger Y, Mackway-Jones K, Rizoli SB, Yukioka T, Hoyt DB. PMID: 18849788.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    32. Acute care surgery: a new training and practice model in the United States. World J Surg. 2008 Aug; 32(8):1630-5. Hoyt DB, Kim HD, Barrios C. PMID: 18408966.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    33. Air medical response to traumatic brain injury: a computer learning algorithm analysis. J Trauma. 2008 Apr; 64(4):889-97. Davis DP, Peay J, Good B, Sise MJ, Kennedy F, Eastman AB, Velky T, Hoyt DB. PMID: 18404053.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. The U.S. trauma surgeon's current scope of practice: can we deliver acute care surgery? J Trauma. 2008 Apr; 64(4):955-65; discussion 965-8. Cothren CC, Moore EE, Hoyt DB. PMID: 18404062.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    35. The impact of safety belt use on liver injuries in motor vehicle crashes: the importance of motor vehicle safety systems. J Trauma. 2007 Aug; 63(2):300-6. Holbrook TL, Hoyt DB, Eastman AB, Sise MJ, Kennedy F, Velky T, Conroy C, Pacyna S, Erwin S. PMID: 17693827.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    36. Motor vehicle-related cardiac and aortic injuries differ from other thoracic injuries. J Trauma. 2007 Jun; 62(6):1462-7. Conroy C, Hoyt DB, Eastman AB, Holbrook TL, Pacyna S, Erwin S, Vaughan T, Sise M, Kennedy F, Velky T. PMID: 17563667.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    37. Hypertonic saline and pentoxifylline attenuates gut injury after hemorrhagic shock: the kinder, gentler resuscitation. J Trauma. 2007 Apr; 62(4):818-27; discussion 827-8. Deree J, de Campos T, Shenvi E, Loomis WH, Hoyt DB, Coimbra R. PMID: 17426535.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    38. Trauma in adolescents causes long-term marked deficits in quality of life: adolescent children do not recover preinjury quality of life or function up to two years postinjury compared to national norms. J Trauma. 2007 Mar; 62(3):577-83; discussion 583. Holbrook TL, Hoyt DB, Coimbra R, Potenza B, Sise MJ, Sack DI, Anderson JP. PMID: 17414331.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    39. From "leaky buckets" to vascular injuries: understanding models of uncontrolled hemorrhage. J Am Coll Surg. 2007 Apr; 204(4):665-72. Hirshberg A, Hoyt DB, Mattox KL. PMID: 17382227.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    40. Damage control resuscitation: directly addressing the early coagulopathy of trauma. J Trauma. 2007 Feb; 62(2):307-10. Holcomb JB, Jenkins D, Rhee P, Johannigman J, Mahoney P, Mehta S, Cox ED, Gehrke MJ, Beilman GJ, Schreiber M, Flaherty SF, Grathwohl KW, Spinella PC, Perkins JG, Beekley AC, McMullin NR, Park MS, Gonzalez EA, Wade CE, Dubick MA, Schwab CW, Moore FA, Champion HR, Hoyt DB, Hess JR. PMID: 17297317.
      View in: PubMed   Mentions: 200     Fields:    Translation:Humans
    41. Head-injured patients who "talk and die": the San Diego perspective. J Trauma. 2007 Feb; 62(2):277-81. Davis DP, Kene M, Vilke GM, Sise MJ, Kennedy F, Eastman AB, Velky T, Hoyt DB. PMID: 17297312.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    42. Hypertonic saline resuscitation: efficacy may require early treatment in severely injured patients. J Trauma. 2007 Feb; 62(2):299-306. Hashiguchi N, Lum L, Romeril E, Chen Y, Yip L, Hoyt DB, Junger WG. PMID: 17297316.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    43. Patient factors and operating room resuscitation predict mortality in traumatic abdominal aortic injury: a 20-year analysis. J Vasc Surg. 2007 Mar; 45(3):493-7. Deree J, Shenvi E, Fortlage D, Stout P, Potenza B, Hoyt DB, Coimbra R. PMID: 17254736.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    44. Practice patterns and outcomes of retrievable vena cava filters in trauma patients: an AAST multicenter study. J Trauma. 2007 Jan; 62(1):17-24; discussion 24-5. Karmy-Jones R, Jurkovich GJ, Velmahos GC, Burdick T, Spaniolas K, Todd SR, McNally M, Jacoby RC, Link D, Janczyk RJ, Ivascu FA, McCann M, Obeid F, Hoff WS, McQuay N, Tieu BH, Schreiber MA, Nirula R, Brasel K, Dunn JA, Gambrell D, Huckfeldt R, Harper J, Schaffer KB, Tominaga GT, Vinces FY, Sperling D, Hoyt D, Coimbra R, Rosengart MR, Forsythe R, Cothren C, Moore EE, Haut ER, Hayanga AJ, Hird L, White C, Grossman J, Nagy K, Livaudais W, Wood R, Zengerink I, Kortbeek JB. PMID: 17215729.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    45. Hypertonic saline and pentoxifylline reduces hemorrhagic shock resuscitation-induced pulmonary inflammation through attenuation of neutrophil degranulation and proinflammatory mediator synthesis. J Trauma. 2007 Jan; 62(1):104-11. Deree J, Martins JO, Leedom A, Lamon B, Putnam J, de Campos T, Hoyt DB, Wolf P, Coimbra R. PMID: 17215740.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    46. Nonoperative management reduces the overall mortality of grades 3 and 4 blunt liver injuries. Int Surg. 2006 Sep-Oct; 91(5):251-7. Coimbra R, Hoyt DB, Engelhart S, Fortlage D. PMID: 17061668.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    47. Pentoxifylline attenuates stored blood-induced inflammation: A new perspective on an old problem. Surgery. 2006 Aug; 140(2):186-91. Deree J, Lall R, Melbostad H, Loomis W, Hoyt DB, Coimbra R. PMID: 16904968.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    48. Neutrophil degranulation and the effects of phosphodiesterase inhibition. J Surg Res. 2006 Jun 01; 133(1):22-8. Deree J, Lall R, Melbostad H, Grant M, Hoyt DB, Coimbra R. PMID: 16690368.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    49. Timing of fluid resuscitation shapes the hemodynamic response to uncontrolled hemorrhage: analysis using dynamic modeling. J Trauma. 2006 Jun; 60(6):1221-7. Hirshberg A, Hoyt DB, Mattox KL. PMID: 16766964.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    50. The predictive value of field versus arrival Glasgow Coma Scale score and TRISS calculations in moderate-to-severe traumatic brain injury. J Trauma. 2006 May; 60(5):985-90. Davis DP, Serrano JA, Vilke GM, Sise MJ, Kennedy F, Eastman AB, Velky T, Hoyt DB. PMID: 16688059.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    51. HSPTX protects against hemorrhagic shock resuscitation-induced tissue injury: an attractive alternative to Ringer's lactate. J Trauma. 2006 Jan; 60(1):41-51. Coimbra R, Porcides R, Loomis W, Melbostad H, Lall R, Deree J, Wolf P, Hoyt DB. PMID: 16456435.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    52. LPS-induced acute lung injury is attenuated by phosphodiesterase inhibition: effects on proinflammatory mediators, metalloproteinases, NF-kappaB, and ICAM-1 expression. J Trauma. 2006 Jan; 60(1):115-25. Coimbra R, Melbostad H, Loomis W, Porcides RD, Wolf P, Tobar M, Hoyt DB. PMID: 16456445.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    53. Recovery at one year following isolated traumatic brain injury: a Western Trauma Association prospective multicenter trial. J Trauma. 2005 Dec; 59(6):1298-304; discussion 1304. Livingston DH, Lavery RF, Mosenthal AC, Knudson MM, Lee S, Morabito D, Manley GT, Nathens A, Jurkovich G, Hoyt DB, Coimbra R. PMID: 16394900.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    54. High rates of acute stress disorder impact quality-of-life outcomes in injured adolescents: mechanism and gender predict acute stress disorder risk. J Trauma. 2005 Nov; 59(5):1126-30. Holbrook TL, Hoyt DB, Coimbra R, Potenza B, Sise M, Anderson JP. PMID: 16385290.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    55. Are we the problem? Overcoming obstacles to implementing intervention programs. J Trauma. 2005 Sep; 59(3 Suppl):S135-6; discussion S146-66. Hoyt DB. PMID: 16355050.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    56. Effect of the Uniform Accident and Sickness Policy Provision Law on alcohol screening and intervention in trauma centers. J Trauma. 2005 Sep; 59(3):624-31. Gentilello LM, Donato A, Nolan S, Mackin RE, Liebich F, Hoyt DB, LaBrie RA. PMID: 16361905.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansPHPublic Health
    57. Phosphodiesterase inhibition decreases nuclear factor-kappaB activation and shifts the cytokine response toward anti-inflammatory activity in acute endotoxemia. J Trauma. 2005 Sep; 59(3):575-82. Coimbra R, Melbostad H, Loomis W, Tobar M, Hoyt DB. PMID: 16361898.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    58. Role of hypertonic saline and pentoxifylline on neutrophil activation and tumor necrosis factor-alpha synthesis: a novel resuscitation strategy. J Trauma. 2005 Aug; 59(2):257-64; discussion 264-5. Coimbra R, Loomis W, Melbostad H, Tobar M, Porcides RD, Lall R, Holbrook T, Hoyt DB. PMID: 16294063.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    59. Reversal of anticoagulation in trauma: a North-American survey on clinical practices among trauma surgeons. J Trauma. 2005 Aug; 59(2):375-82. Coimbra R, Hoyt DB, Anjaria DJ, Potenza BM, Fortlage D, Hollingsworth-Fridlund P. PMID: 16294078.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    60. A follow-up analysis of factors associated with head-injury mortality after paramedic rapid sequence intubation. J Trauma. 2005 Aug; 59(2):486-90. Davis DP, Stern J, Sise MJ, Hoyt DB. PMID: 16294099.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    61. The impact of prehospital endotracheal intubation on outcome in moderate to severe traumatic brain injury. J Trauma. 2005 May; 58(5):933-9. Davis DP, Peay J, Sise MJ, Vilke GM, Kennedy F, Eastman AB, Velky T, Hoyt DB. PMID: 15920406.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    62. Long-term posttraumatic stress disorder persists after major trauma in adolescents: new data on risk factors and functional outcome. J Trauma. 2005 Apr; 58(4):764-9; discussion 769-71. Holbrook TL, Hoyt DB, Coimbra R, Potenza B, Sise M, Anderson JP. PMID: 15824653.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    63. Metastatic meningioma to the liver successfully treated with a wedge resection and radiation therapy: report of a case. Surg Today. 2005; 35(1):82-5. Ku JK, Vasquez JC, Hoyt DB, Coimbra R. PMID: 15622471.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    64. Nonspecific phosphodiesterase inhibition attenuates liver injury in acute endotoxemia. Surg Infect (Larchmt). 2005; 6(1):73-85. Coimbra R, Porcides RD, Melbostad H, Loomis W, Tobar M, Hoyt DB, Wolf P. PMID: 15865553.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    65. LPS-stimulated PMN activation and proinflammatory mediator synthesis is downregulated by phosphodiesterase inhibition: role of pentoxifylline. J Trauma. 2004 Dec; 57(6):1157-63. Coimbra R, Loomis W, Melbostad H, Tobar M, Porcides RD, Hoyt DB. PMID: 15625444.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    66. Working Group on Trauma Research Program summary report: National Heart Lung Blood Institute (NHLBI), National Institute of General Medical Sciences (NIGMS), and National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH), and the Department of Defense (DOD). J Trauma. 2004 Aug; 57(2):410-5. Hoyt DB, Holcomb J, Abraham E, Atkins J, Sopko G, Working Group on Trauma Research . PMID: 15345998.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    67. Intestinal lymphoma causing intussusception in HIV(+) patient: a rare presentation. Curr Surg. 2004 Jul-Aug; 61(4):386-9. Farrier J, Dinerman C, Hoyt DB, Coimbra R. PMID: 15276346.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    68. The impact of hypoxia and hyperventilation on outcome after paramedic rapid sequence intubation of severely head-injured patients. J Trauma. 2004 Jul; 57(1):1-8; discussion 8-10. Davis DP, Dunford JV, Poste JC, Ochs M, Holbrook T, Fortlage D, Size MJ, Kennedy F, Hoyt DB. PMID: 15284540.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCTClinical Trials
    69. The use of recombinant factor VIIa for severe intractable bleeding during spine surgery. Spine (Phila Pa 1976). 2004 Jun 15; 29(12):1384-7; discussion 1388. Kaw LL, Coimbra R, Potenza BM, Garfin SR, Hoyt DB. PMID: 15187645.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    70. The effect of age on functional outcome in mild traumatic brain injury: 6-month report of a prospective multicenter trial. J Trauma. 2004 May; 56(5):1042-8. Mosenthal AC, Livingston DH, Lavery RF, Knudson MM, Lee S, Morabito D, Manley GT, Nathens A, Jurkovich G, Hoyt DB, Coimbra R. PMID: 15179244.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    71. The use of quantitative end-tidal capnometry to avoid inadvertent severe hyperventilation in patients with head injury after paramedic rapid sequence intubation. J Trauma. 2004 Apr; 56(4):808-14. Davis DP, Dunford JV, Ochs M, Park K, Hoyt DB. PMID: 15187747.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    72. Inhibition of enteral enzymes by enteroclysis with nafamostat mesilate reduces neutrophil activation and transfusion requirements after hemorrhagic shock. J Trauma. 2004 Mar; 56(3):501-10; discussion 510-1. Doucet JJ, Hoyt DB, Coimbra R, Schmid-Schönbein GW, Junger WG, Paul L W, Loomis WH, Hugli TE. PMID: 15128119.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    73. Urgent and emergent thoracotomy for penetrating chest trauma. J Trauma. 2004 Mar; 56(3):664-8; discussion 668-9. Karmy-Jones R, Nathens A, Jurkovich GJ, Shatz DV, Brundage S, Wall MJ, Engelhardt S, Hoyt DB, Holcroft J, Knudson MM, Michaels A, Long W. PMID: 15128141.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansPHPublic Health
    74. Effects of phosphodiesterase inhibition on the inflammatory response after shock: role of pentoxifylline. J Trauma. 2004 Feb; 56(2):442-9. Coimbra R, Melbostad H, Hoyt DB. PMID: 14960994.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    75. The impact of major trauma: quality-of-life outcomes are worse in women than in men, independent of mechanism and injury severity. J Trauma. 2004 Feb; 56(2):284-90. Holbrook TL, Hoyt DB. PMID: 14960969.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    76. Acute cholecystitis with a hemocholecyst as an unusual presentation of gallbladder cancer: report of a case. Surg Today. 2004; 34(11):973-6. Ku J, DeLaRosa J, Kang J, Hoyt D, Coimbra R. PMID: 15526137.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    77. The epidemiology of serious and fatal injury in San Diego County over an 11-year period. J Trauma. 2004 Jan; 56(1):68-75. Potenza BM, Hoyt DB, Coimbra R, Fortlage D, Holbrook T, Hollingsworth-Fridlund P, Trauma Research and Education Foundation . PMID: 14749568.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    78. Rock on--staying focused on our way to greatness. J Trauma. 2004 Jan; 56(1):1-6. Hoyt DB. PMID: 14749558.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    79. Outcomes in open tibia fractures: relationship between delay in treatment and infection. J Trauma. 2003 Nov; 55(5):949-54. Khatod M, Botte MJ, Hoyt DB, Meyer RS, Smith JM, Akeson WH. PMID: 14608171.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    80. Pentoxifylline reduces acute lung injury in chronic endotoxemia. J Surg Res. 2003 Nov; 115(1):92-9. Michetti C, Coimbra R, Hoyt DB, Loomis W, Junger W, Wolf P. PMID: 14572778.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    81. National survey of trauma surgeons' use of alcohol screening and brief intervention. J Trauma. 2003 Nov; 55(5):849-56. Schermer CR, Gentilello LM, Hoyt DB, Moore EE, Moore JB, Rozycki GS, Feliciano DV. PMID: 14608155.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansPHPublic Health
    82. Paramedic-administered neuromuscular blockade improves prehospital intubation success in severely head-injured patients. J Trauma. 2003 Oct; 55(4):713-9. Davis DP, Ochs M, Hoyt DB, Bailey D, Marshall LK, Rosen P. PMID: 14566128.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    83. Fluid resuscitation: the target from an analysis of trauma systems and patient survival. J Trauma. 2003 May; 54(5 Suppl):S31-5. Hoyt DB. PMID: 12768099.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    84. Does sexual dimorphism influence outcome of traumatic brain injury patients? The answer is no! J Trauma. 2003 Apr; 54(4):689-700. Coimbra R, Hoyt DB, Potenza BM, Fortlage D, Hollingsworth-Fridlund P. PMID: 12707530.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    85. The effect of paramedic rapid sequence intubation on outcome in patients with severe traumatic brain injury. J Trauma. 2003 Mar; 54(3):444-53. Davis DP, Hoyt DB, Ochs M, Fortlage D, Holbrook T, Marshall LK, Rosen P. PMID: 12634522.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    86. A twelve-year analysis of disease and provider complications on an organized level I trauma service: as good as it gets? J Trauma. 2003 Jan; 54(1):26-36; discussion 36-7. Hoyt DB, Coimbra R, Potenza B, Doucet J, Fortlage D, Holingsworth-Fridlund P, Holbrook T. PMID: 12544896.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    87. An assessment of the potential for reducing future combat deaths through medical technologies and training. J Trauma. 2002 Dec; 53(6):1160-5. Blood CG, Puyana JC, Pitlyk PJ, Hoyt DB, Bjerke HS, Fridman J, Walker GJ, Zouris JM, Zhang J. PMID: 12478044.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    88. Gender differences in long-term posttraumatic stress disorder outcomes after major trauma: women are at higher risk of adverse outcomes than men. J Trauma. 2002 Nov; 53(5):882-8. Holbrook TL, Hoyt DB, Stein MB, Sieber WJ. PMID: 12435938.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    89. Female gender does not protect blunt trauma patients from complications and mortality. J Trauma. 2002 Sep; 53(3):436-41; discussion 441. Rappold JF, Coimbra R, Hoyt DB, Potenza BM, Fortlage D, Holbrook T, Minard G. PMID: 12352477.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
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