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William E Karnes

Title(s)Health Sciences Professor, Medicine
Phone(714) 456-6745
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    BETA-CATENIN AND RAR INTERACT AT THE PKC ALPHA PROMOTER
    NIH/NIDDK R01DK056378Aug 1, 1999 - Jul 31, 2004
    Role: Co-Principal Investigator
    PKC--MEDIATED GROWTH AND APOPTOSIS
    NIH/NCI R29CA071974Sep 30, 1996 - Sep 29, 2001
    Role: Principal Investigator
    MECHANISMS OF LIGAND-INDEPENDENT TRANSFORMATION BY C-ERB
    NIH/NCI K11CA001674Sep 1, 1992 - Aug 31, 1997
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zachariah R, Samarasena J, Luba D, Duh E, Dao T, Requa J, Ninh A, Karnes W. Prediction of Polyp Pathology Using Convolutional Neural Networks Achieves "Resect and Discard" Thresholds. Am J Gastroenterol. 2019 Oct 23. PMID: 31651444.
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    2. Urban G, Tripathi P, Alkayali T, Mittal M, Jalali F, Karnes W, Baldi P. Deep Learning Localizes and Identifies Polyps in Real Time With 96% Accuracy in Screening Colonoscopy. Gastroenterology. 2018 10; 155(4):1069-1078.e8. PMID: 29928897.
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    3. Chin M, Karnes W, Jamal MM, Lee JG, Lee R, Samarasena J, Bechtold ML, Nguyen DL. Use of the Endocuff during routine colonoscopy examination improves adenoma detection: A meta-analysis. World J Gastroenterol. 2016 Nov 21; 22(43):9642-9649. PMID: 27920485.
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    4. Tsang WY, Ziogas A, Lin BS, Seery TE, Karnes W, Stamos MJ, Zell JA. Role of primary tumor resection among chemotherapy-treated patients with synchronous stage IV colorectal cancer: a survival analysis. J Gastrointest Surg. 2014 Mar; 18(3):592-8. PMID: 24297651.
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    5. Ritland SR, Gendler SJ, Burgart LJ, Fry DW, Nelson JM, Bridges AJ, Andress L, Karnes WE. Inhibition of epidermal growth factor receptor tyrosine kinase fails to suppress adenoma formation in ApcMin mice but induces duodenal injury. Cancer Res. 2000 Sep 01; 60(17):4678-81. PMID: 10987266.
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    6. Klein IK, Ritland SR, Burgart LJ, Ziesmer SC, Roche PC, Gendler SJ, Karnes WE. Adenoma-specific alterations of protein kinase C isozyme expression in Apc(MIN) mice. Cancer Res. 2000 Apr 15; 60(8):2077-80. PMID: 10786662.
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    7. Karnes WE. Implications of low COX-2 expression in colorectal neoplasms with defective DNA mismatch repair. J Cell Biochem Suppl. 2000; 34:23-7. PMID: 10762011.
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    8. Weller SG, Klein IK, Penington RC, Karnes WE. Distinct protein kinase C isozymes signal mitogenesis and apoptosis in human colon cancer cells. Gastroenterology. 1999 Oct; 117(4):848-57. PMID: 10500067.
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    9. Desai DS, Hirai S, Karnes WE, Niles RM, Ohno S. Cloning and characterization of the murine PKC alpha promoter: identification of a retinoic acid response element. Biochem Biophys Res Commun. 1999 Sep 16; 263(1):28-34. PMID: 10486248.
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    10. Karnes WE, Shattuck-Brandt R, Burgart LJ, DuBois RN, Tester DJ, Cunningham JM, Kim CY, McDonnell SK, Schaid DJ, Thibodeau SN. Reduced COX-2 protein in colorectal cancer with defective mismatch repair. Cancer Res. 1998 Dec 01; 58(23):5473-7. PMID: 9850081.
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    11. Karnes WE, Weller SG, Adjei PN, Kottke TJ, Glenn KS, Gores GJ, Kaufmann SH. Inhibition of epidermal growth factor receptor kinase induces protease-dependent apoptosis in human colon cancer cells. Gastroenterology. 1998 May; 114(5):930-9. PMID: 9558281.
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    12. Rand A, Glenn KS, Alvares CP, White MB, Thibodeau SM, Karnes WE. p53 functional loss in a colon cancer cell line with two missense mutations (218leu and 248trp) on separate alleles. Cancer Lett. 1996 Jan 02; 98(2):183-91. PMID: 8556707.
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    13. Boardman LA, Karnes WE. Src family of tyrosine kinases: a role of c-yes in colon carcinogenesis? Gastroenterology. 1995 Jan; 108(1):291-4. PMID: 7806054.
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    14. Kaufman DK, Brown RD, Karnes WE. Involuntary tonic spasms of a limb due to a brain stem lacunar infarction. Stroke. 1994 Jan; 25(1):217-9. PMID: 8266372.
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    15. Rodriguez M, Karnes WE, Bartleson JD, Pineda AA. Plasmapheresis in acute episodes of fulminant CNS inflammatory demyelination. Neurology. 1993 Jun; 43(6):1100-4. PMID: 8170550.
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    16. Chen MC, Lee AT, Karnes WE, Avedian D, Martin M, Sorvillo JM, Soll AH. Paracrine control of gastric epithelial cell growth in culture by transforming growth factor-alpha. Am J Physiol. 1993 Feb; 264(2 Pt 1):G390-6. PMID: 8447422.
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    17. Craig PM, Territo MC, Karnes WE, Walsh JH. Helicobacter pylori secretes a chemotactic factor for monocytes and neutrophils. Gut. 1992 Aug; 33(8):1020-3. PMID: 1398224.
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    18. Karnes WE, Walsh JH, Wu SV, Kim RS, Martin MG, Wong HC, Mendelsohn J, Park JG, Cuttitta F. Autonomous proliferation of colon cancer cells that coexpress transforming growth factor alpha and its receptor. Variable effects of receptor-blocking antibody. Gastroenterology. 1992 Feb; 102(2):474-85. PMID: 1732118.
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    19. Goldschmiedt M, Barnett CC, Schwarz BE, Karnes WE, Redfern JS, Feldman M. Effect of age on gastric acid secretion and serum gastrin concentrations in healthy men and women. Gastroenterology. 1991 Oct; 101(4):977-90. PMID: 1889722.
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    20. Walsh JH, Karnes WE, Cuttitta F, Walker A. Autocrine growth factors and solid tumor malignancy. West J Med. 1991 Aug; 155(2):152-63. PMID: 1926844.
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    21. Karnes WE, Ohning GV, Sytnik B, Kim SW, Walsh JH. Elevation of meal-stimulated gastrin release in subjects with Helicobacter pylori infection: reversal by low intragastric pH. Rev Infect Dis. 1991 Jul-Aug; 13 Suppl 8:S665-70. PMID: 1925307.
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    22. Karnes WE, Samloff IM, Siurala M, Kekki M, Sipponen P, Kim SW, Walsh JH. Positive serum antibody and negative tissue staining for Helicobacter pylori in subjects with atrophic body gastritis. Gastroenterology. 1991 Jul; 101(1):167-74. PMID: 2044906.
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    23. Karnes WE, Berlin RG, Maxwell V, Sytnik B, Root JK, Walsh JH. Prolonged inhibition of acid secretion causes hypergastrinaemia without altering pH inhibition of gastrin release in humans. Aliment Pharmacol Ther. 1990 Oct; 4(5):443-56. PMID: 2129633.
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    24. Karnes WE, Walsh JH. The gastrin hypothesis. Implications for antisecretory drug selection. J Clin Gastroenterol. 1990; 12 Suppl 2:S7-12. PMID: 2246496.
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    25. Karnes WE, Maxwell V, Sytnik B, Chew P, Walsh JH. Prolonged inhibition of meal-stimulated acid secretion and gastrin release following single subcutaneous administration of octreotide (SMS 201-995) in man. Aliment Pharmacol Ther. 1989 Dec; 3(6):527-38. PMID: 2518866.
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