William E Karnes

Title(s)Health Sciences Professor, Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(714) 456-6745
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    BETA-CATENIN AND RAR INTERACT AT THE PKC ALPHA PROMOTER
    NIH R01DK056378Aug 1, 1999 - Jul 31, 2004
    Role: Co-Principal Investigator
    PKC--MEDIATED GROWTH AND APOPTOSIS
    NIH R29CA071974Sep 30, 1996 - Sep 29, 2001
    Role: Principal Investigator
    MECHANISMS OF LIGAND-INDEPENDENT TRANSFORMATION BY C-ERB
    NIH K11CA001674Sep 1, 1992 - Aug 31, 1997
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Polyp Worth Removing: A Paradigm for Measuring Colonoscopy Quality and Performance of Novel Technologies for Polyp Detection. J Clin Gastroenterol. 2021 Oct 01; 55(9):733-739. Karnes WE, Johnson DA, Berzin TM, Gross SA, Vargo JJ, Sharma P, Zachariah R, Samarasena JB, Anderson JC. PMID: 34334765.
      View in: PubMed   Mentions:    Fields:    
    2. Single-Day Low-Residue Diet Prior to Colonoscopy Demonstrates Improved Bowel Preparation Quality and Patient Tolerance over Clear Liquid Diet: A Randomized, Single-Blinded, Dual-Center Trial. Dig Dis Sci. 2021 Jun 10. Samarasena JB, El Hage Chehade N, Abadir A, Yu A, Tran E, Mai D, Thieu D, Albers G, Parekh NK, Karnes WE, Chang K, Jamal MM. PMID: 34114154.
      View in: PubMed   Mentions:    Fields:    
    3. Microbiome distinctions between the CRC carcinogenic pathways. Gut Microbes. 2021 Jan-Dec; 13(1):1854641. DeDecker L, Coppedge B, Avelar-Barragan J, Karnes W, Whiteson K. PMID: 33446008.
      View in: PubMed   Mentions: 2     Fields:    
    4. Establishing key research questions for the implementation of artificial intelligence in colonoscopy: a modified Delphi method. Endoscopy. 2021 09; 53(9):893-901. Ahmad OF, Mori Y, Misawa M, Kudo SE, Anderson JT, Bernal J, Berzin TM, Bisschops R, Byrne MF, Chen PJ, East JE, Eelbode T, Elson DS, Gurudu SR, Histace A, Karnes WE, Repici A, Singh R, Valdastri P, Wallace MB, Wang P, Stoyanov D, Lovat LB. PMID: 33167043.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Central Reading of Ulcerative Colitis Clinical Trial Videos Using Neural Networks. Gastroenterology. 2021 02; 160(3):710-719.e2. Gottlieb K, Requa J, Karnes W, Chandra Gudivada R, Shen J, Rael E, Arora V, Dao T, Ninh A, McGill J. PMID: 33098883.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    6. Endoscopy and central reading in inflammatory bowel disease clinical trials: achievements, challenges and future developments. Gut. 2021 02; 70(2):418-426. Gottlieb K, Daperno M, Usiskin K, Sands BE, Ahmad H, Howden CW, Karnes W, Oh YS, Modesto I, Marano C, Stidham RW, Reinisch W. PMID: 32699100.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Oral IBGard™ Before Colonoscopy: A Single-Center Double-Blinded, Randomized, Placebo-Controlled Trial. Dig Dis Sci. 2021 05; 66(5):1611-1619. Han JY, Moosvi Z, Duh E, Park S, Albers GC, Samarasena JB, Karnes W. PMID: 32519140.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Traditional serrated adenomas (TSA) and the company they keep: TSA presence predicts advanced neoplasm states. Int J Colorectal Dis. 2020 Jul; 35(7):1351-1354. Duh E, Sowa P, Roberts MB, Karnes W. PMID: 32358718.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Artificial Intelligence in Gastrointestinal Endoscopy. Clin Endosc. 2020 Mar; 53(2):132-141. Abadir AP, Ali MF, Karnes W, Samarasena JB. PMID: 32252506.
      View in: PubMed   Mentions:
    10. Artificial intelligence using convolutional neural networks for real-time detection of early esophageal neoplasia in Barrett's esophagus (with video). Gastrointest Endosc. 2020 06; 91(6):1264-1271.e1. Hashimoto R, Requa J, Dao T, Ninh A, Tran E, Mai D, Lugo M, El-Hage Chehade N, Chang KJ, Karnes WE, Samarasena JB. PMID: 31930967.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    11. Prediction of Polyp Pathology Using Convolutional Neural Networks Achieves "Resect and Discard" Thresholds. Am J Gastroenterol. 2020 01; 115(1):138-144. Zachariah R, Samarasena J, Luba D, Duh E, Dao T, Requa J, Ninh A, Karnes W. PMID: 31651444.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansPHPublic Health
    12. Deep Learning Localizes and Identifies Polyps in Real Time With 96% Accuracy in Screening Colonoscopy. Gastroenterology. 2018 10; 155(4):1069-1078.e8. Urban G, Tripathi P, Alkayali T, Mittal M, Jalali F, Karnes W, Baldi P. PMID: 29928897.
      View in: PubMed   Mentions: 99     Fields:    Translation:Humans
    13. Use of the Endocuff during routine colonoscopy examination improves adenoma detection: A meta-analysis. World J Gastroenterol. 2016 Nov 21; 22(43):9642-9649. Chin M, Karnes W, Jamal MM, Lee JG, Lee R, Samarasena J, Bechtold ML, Nguyen DL. PMID: 27920485.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    14. Role of primary tumor resection among chemotherapy-treated patients with synchronous stage IV colorectal cancer: a survival analysis. J Gastrointest Surg. 2014 Mar; 18(3):592-8. Tsang WY, Ziogas A, Lin BS, Seery TE, Karnes W, Stamos MJ, Zell JA. PMID: 24297651.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    15. Distinct protein kinase C isozymes signal mitogenesis and apoptosis in human colon cancer cells. Gastroenterology. 1999 Oct; 117(4):848-57. Weller SG, Klein IK, Penington RC, Karnes WE. PMID: 10500067.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    16. Reduced COX-2 protein in colorectal cancer with defective mismatch repair. Cancer Res. 1998 Dec 01; 58(23):5473-7. Karnes WE, Shattuck-Brandt R, Burgart LJ, DuBois RN, Tester DJ, Cunningham JM, Kim CY, McDonnell SK, Schaid DJ, Thibodeau SN. PMID: 9850081.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    17. Inhibition of epidermal growth factor receptor kinase induces protease-dependent apoptosis in human colon cancer cells. Gastroenterology. 1998 May; 114(5):930-9. Karnes WE, Weller SG, Adjei PN, Kottke TJ, Glenn KS, Gores GJ, Kaufmann SH. PMID: 9558281.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    18. Src family of tyrosine kinases: a role of c-yes in colon carcinogenesis? Gastroenterology. 1995 Jan; 108(1):291-4. Boardman LA, Karnes WE. PMID: 7806054.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Autonomous proliferation of colon cancer cells that coexpress transforming growth factor alpha and its receptor. Variable effects of receptor-blocking antibody. Gastroenterology. 1992 Feb; 102(2):474-85. Karnes WE, Walsh JH, Wu SV, Kim RS, Martin MG, Wong HC, Mendelsohn J, Park JG, Cuttitta F. PMID: 1732118.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    20. Positive serum antibody and negative tissue staining for Helicobacter pylori in subjects with atrophic body gastritis. Gastroenterology. 1991 Jul; 101(1):167-74. Karnes WE, Samloff IM, Siurala M, Kekki M, Sipponen P, Kim SW, Walsh JH. PMID: 2044906.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    21. The gastrin hypothesis. Implications for antisecretory drug selection. J Clin Gastroenterol. 1990; 12 Suppl 2:S7-12. Karnes WE, Walsh JH. PMID: 2246496.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
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