Sudhir Gupta

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-5818, 8600
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    Collapse Research 
    Collapse Research Activities and Funding
    TNF-Induced Apoptosis of Lymphocytes in Aged Humans
    NIH R01AG018313Jun 1, 2002 - Apr 30, 2006
    Role: Principal Investigator
    NIH R13AI039530Feb 1, 1996 - Jan 31, 1997
    Role: Principal Investigator
    NIH R13AI029498Feb 15, 1990 - Feb 14, 1991
    Role: Principal Investigator
    NIH R01AI026465Jul 1, 1988 - Mar 31, 1992
    Role: Principal Investigator
    NIH R13AI025809Sep 30, 1987 - Aug 31, 1988
    Role: Principal Investigator
    NIH R13AI023582Feb 26, 1986 - Feb 25, 1987
    Role: Principal Investigator
    NIH R01AG004361Apr 1, 1984 - Nov 30, 1987
    Role: Principal Investigator
    NIH R01AI020717Sep 15, 1983 - Mar 31, 1987
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Subcutaneous Immunoglobulin 16.5% (Cutaquig®) in Primary Immunodeficiency Disease: Safety, Tolerability, Efficacy, and Patient Experience with Enhanced Infusion Regimens. J Clin Immunol. 2023 08; 43(6):1414-1425. Gupta S, DeAngelo J, Melamed I, Walter JE, Kobayashi AL, Bridges T, Sublett JW, Bernstein JA, Koterba A, Manning M, Maltese J, Hoeller S, Turpel-Kantor E, Kreuwel H, Kobayashi RH. PMID: 37160610; PMCID: PMC10169187.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Infections in DNA Repair Defects. Pathogens. 2023 Mar 10; 12(3). Yilmaz Demirdag Y, Gupta S. PMID: 36986362; PMCID: PMC10054915.
      View in: PubMed   Mentions:
    3. Dendritic cells in inborn errors of immunity. Front Immunol. 2023; 14:1080129. Gupta S, Agrawal A. PMID: 36756122; PMCID: PMC9899832.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Subcutaneous immunoglobulin 16.5% for the treatment of pediatric patients with primary antibody immunodeficiency. Expert Rev Clin Immunol. 2022 Nov 15; 1-11. Gupta S, Kobayashi RH, Litzman J, Cherwin L, Hoeller S, Kreuwel H. PMID: 36346032.
      View in: PubMed   Mentions: 1     Fields:    
    5. SARS-CoV-2-Specific and Functional Cytotoxic CD8 Cells in Primary Antibody Deficiency: Natural Infection and Response to Vaccine. J Clin Immunol. 2022 07; 42(5):914-922. Gupta S, Agrawal S, Sandoval A, Su H, Tran M, Demirdag Y. PMID: 35366743; PMCID: PMC8976534.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    6. Immune Response to SARS-CoV-2 Vaccine in 2 Men. Int Arch Allergy Immunol. 2022; 183(3):350-359. Gupta S, Su H, Agrawal S. PMID: 34794147; PMCID: PMC8678225.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    7. Editorial: Advances in Primary Immunodeficiencies in India. Front Immunol. 2021; 12:701335. Gupta S, Sehgal S. PMID: 34249007; PMCID: PMC8263926.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. Collagenous Gastritis in Primary Selective IgM Deficiency: Transition to EBV+ Gastric Adenocarcinoma. Case Reports Immunol. 2021; 2021:5574944. Narsai T, Su H, Braxton D, Gupta S. PMID: 34123443; PMCID: PMC8172285.
      View in: PubMed   Mentions: 2  
    9. Progression of primary selective immunoglobulin M deficiency to common variable immunodeficiency. Ann Allergy Asthma Immunol. 2021 06; 126(6):723-724. Narsai T, Gupta S. PMID: 33607249.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Update on Infections in Primary Antibody Deficiencies. Front Immunol. 2021; 12:634181. Demirdag YY, Gupta S. PMID: 33643318; PMCID: PMC7905085.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    11. SARS-CoV-2-Associated T-Cell Responses in the Presence of Humoral Immunodeficiency. Int Arch Allergy Immunol. 2021; 182(3):195-209. Gupta S, Su H, Narsai T, Agrawal S. PMID: 33486489; PMCID: PMC7900460.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    12. Reconstitution of IgG Subclasses Following Immunoglobulin Administration in Adult Patients with Common Variable Immune Deficiency. Int Arch Allergy Immunol. 2021; 182(3):243-253. Reeder D, Gupta S. PMID: 33053553.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. CD8 Treg Cells Inhibit B-Cell Proliferation and Immunoglobulin Production. Int Arch Allergy Immunol. 2020; 181(12):947-955. Gupta S, Su H, Agrawal S. PMID: 32799212.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    14. Phenotypic analysis of T follicular helper and T follicular regulatory cells in primary selective IgM deficiency. Hum Immunol. 2020 Oct - Nov; 81(10-11):625-633. Kasahara TM, Bento CAM, Gupta S. PMID: 32773096.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    15. Phenotypically defined subpopulations of circulating follicular helper T cells in common variable immunodeficiency. Immun Inflamm Dis. 2020 09; 8(3):441-446. Yesillik S, Gupta S. PMID: 32618135; PMCID: PMC7416056.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    16. Actinotignum schaalii Abscess in a Patient with Common Variable Immunodeficiency. Pathogens. 2020 Jun 22; 9(6). Panganiban CM, Gupta S. PMID: 32580346; PMCID: PMC7350303.
      View in: PubMed   Mentions: 2  
    17. In vitro Effects of CD8+ Regulatory T Cells on Human B Cell Subpopulations. Int Arch Allergy Immunol. 2020; 181(6):476-480. Gupta S, Agrawal S. PMID: 32248193.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    18. Retraction Note: Role of the NF-κB signaling cascade and NF-κB-targeted genes in failing human hearts. J Mol Med (Berl). 2020 04; 98(4):613. Gupta S, Sen S. PMID: 32221639.
      View in: PubMed   Mentions:    Fields:    
    19. Comprehensive clinical and immunological features of 62 adult patients with selective primary IgM deficiency. Am J Clin Exp Immunol. 2019; 8(6):55-67. Lucuab-Fegurgur DL, Gupta S. PMID: 31970029; PMCID: PMC6971419.
      View in: PubMed   Mentions: 6  
    20. Reconstitution of IgG Subclasses following Immunoglobulin Therapy in Adult Primary Hypogammaglobulinemia. Int Arch Allergy Immunol. 2019; 180(3):221-232. Sharma T, Gupta S. PMID: 31509832.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    21. IgAλ monoclonal gammopathy of undetermined significance (MGUS) associated with primary selective IgM deficiency. Am J Clin Exp Immunol. 2019; 8(4):37-46. Gupta S, Agrawal S. PMID: 31497382; PMCID: PMC6726973.
      View in: PubMed   Mentions: 3  
    22. Clinical and Immunological Features of 78 Adult Patients with Primary Selective IgG Subclass Deficiencies. Arch Immunol Ther Exp (Warsz). 2019 Oct; 67(5):325-334. Khokar A, Gupta S. PMID: 31363786.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    23. Phenotypic Analysis of CD4+ Treg, CD8+ Treg, and Breg Cells in Adult Common Variable Immunodeficiency Patients. Int Arch Allergy Immunol. 2019; 180(2):150-158. Yesillik S, Agrawal S, Gollapudi SV, Gupta S. PMID: 31284281.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    24. Tolerability of Ig20Gly during onboarding in patients with primary immunodeficiency diseases. Ann Allergy Asthma Immunol. 2019 09; 123(3):271-279.e1. Gupta S, Stein M, Hussain I, Paris K, Engl W, McCoy B, Rabbat CJ, Yel L. PMID: 31228628.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    25. Defining Primary Selective IgM Deficiency. J Clin Immunol. 2019 05; 39(4):350-352. Gupta S, Gupta A. PMID: 31073845.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    26. Cytomegalovirus Colitis in Primary Hypogammaglobulinemia With Normal CD4+ T Cells: Deficiency of CMV-Specific CD8+ T Cells. Front Immunol. 2019; 10:399. Agrawal S, Khokhar A, Gupta S. PMID: 30899266; PMCID: PMC6416218.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    27. Molecular changes associated with increased TNF-α-induced apoptotis in naïve (TN) and central memory (TCM) CD8+ T cells in aged humans. Immun Ageing. 2018; 15:2. Gupta S, Su H, Agrawal S, Gollapudi S. PMID: 29387134; PMCID: PMC5775550.
      View in: PubMed   Mentions: 5  
    28. IgG4-related disease presenting as hoarseness and postcricoid ulcer. Ann Allergy Asthma Immunol. 2018 02; 120(2):211-212. Hamadani S, Wang B, Gupta S. PMID: 29217085.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    29. Selective IgM Deficiency-An Underestimated Primary Immunodeficiency. Front Immunol. 2017; 8:1056. Gupta S, Gupta A. PMID: 28928736; PMCID: PMC5591887.
      View in: PubMed   Mentions: 40     Fields:    
    30. Role of Dendritic Cells in Inflammation and Loss of Tolerance in the Elderly. Front Immunol. 2017; 8:896. Agrawal A, Agrawal S, Gupta S. PMID: 28798751; PMCID: PMC5526855.
      View in: PubMed   Mentions: 65     Fields:    
    31. FcμR in human B cell subsets in primary selective IgM deficiency, and regulation of FcμR and production of natural IgM antibodies by IGIV. Hum Immunol. 2016 Dec; 77(12):1194-1201. Gupta S, Agrawal S, Gollapudi S, Kubagawa H. PMID: 27751883; PMCID: PMC5812685.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    32. Anaphylaxis to IVIG. Arch Immunol Ther Exp (Warsz). 2017 Feb; 65(1):11-19. Williams SJ, Gupta S. PMID: 27412077.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    33. Anaphylaxis to IGIV in immunoglobulin-naïve common variable immunodeficiency patient in the absence of IgG anti-IgA antibodies: successful administration of low IgA-containing immunoglobulin. Allergy Asthma Clin Immunol. 2016; 12:23. Gharib A, Caperton C, Gupta S. PMID: 27190527; PMCID: PMC4869305.
      View in: PubMed   Mentions: 3  
    34. Ins and Outs of Antibodies. J Clin Immunol. 2016 05; 36 Suppl 1:1-4. Gupta S. PMID: 27169867.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    35. Reversal of oxidative stress-induced apoptosis in T and B lymphocytes by Coenzyme Q10 (CoQ10). Am J Clin Exp Immunol. 2016; 5(2):41-7. Gollapudi S, Gupta S. PMID: 27168954; PMCID: PMC4858601.
      View in: PubMed   Mentions: 6  
    36. Analysis of subsets of B cells, Breg, CD4Treg and CD8Treg cells in adult patients with primary selective IgM deficiency. Am J Clin Exp Immunol. 2016; 5(1):21-32. Louis AG, Agrawal S, Gupta S. PMID: 27168952; PMCID: PMC4858603.
      View in: PubMed   Mentions: 17  
    37. Common variable immunodeficiency associated with microdeletion of chromosome 1q42.1-q42.3 and inositol 1,4,5-trisphosphate kinase B (ITPKB) deficiency. Clin Transl Immunology. 2016 Jan; 5(1):e59. Louis AG, Yel L, Cao JN, Agrawal S, Gupta S. PMID: 26900472; PMCID: PMC4735063.
      View in: PubMed   Mentions: 8  
    38. Good syndrome presenting with CD8⁺ T-Cell large granular lymphocyte leukemia. Oncotarget. 2015 Nov 03; 6(34):36577-86. Caperton C, Agrawal S, Gupta S. PMID: 26429871; PMCID: PMC4742196.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    39. Syndrome of selective IgM deficiency with severe T cell deficiency associated with disseminated cutaneous mycobacterium avium intracellulaire infection. Am J Clin Exp Immunol. 2015; 4(2):15-27. Gharib A, Louis AG, Agrawal S, Gupta S. PMID: 26550546; PMCID: PMC4620120.
      View in: PubMed   Mentions: 6  
    40. Thymosin Beta 4 protects mice from monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy. PLoS One. 2014; 9(11):e110598. Wei C, Kim IK, Li L, Wu L, Gupta S. PMID: 25412097; PMCID: PMC4239012.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    41. Alterations in gene array patterns in dendritic cells from aged humans. PLoS One. 2014; 9(9):e106471. Cao JN, Agrawal A, Sharman E, Jia Z, Gupta S. PMID: 25191744; PMCID: PMC4156347.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    42. Dendritic cells from aged subjects display enhanced inflammatory responses to Chlamydophila pneumoniae. Mediators Inflamm. 2014; 2014:436438. Prakash S, Agrawal S, Ma D, Gupta S, Peterson EM, Agrawal A. PMID: 25253920; PMCID: PMC4165882.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    43. The science and arts of antibodies. J Clin Immunol. 2014 Jul; 34 Suppl 1:S1-3. Gupta S, Schwarz HP. PMID: 24760115.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    44. Can microRNAs emerge as biomarkers in distinguishing HFpEF versus HFrEF? Int J Cardiol. 2014 Aug 20; 175(3):395-9. Nair N, Gupta S, Collier IX, Gongora E, Vijayaraghavan K. PMID: 25002320.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    45. NF-κB-mediated integrin-linked kinase regulation in angiotensin II-induced pro-fibrotic process in cardiac fibroblasts. Life Sci. 2014 Jun 27; 107(1-2):68-75. Thakur S, Li L, Gupta S. PMID: 24802124.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    46. Primary selective IgM deficiency: an ignored immunodeficiency. Clin Rev Allergy Immunol. 2014 Apr; 46(2):104-11. Louis AG, Gupta S. PMID: 23760686.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    47. Inhibition of nuclear factor-κB in the lungs prevents monocrotaline-induced pulmonary hypertension in mice. Hypertension. 2014 Jun; 63(6):1260-9. Li L, Wei C, Kim IK, Janssen-Heininger Y, Gupta S. PMID: 24614212.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    48. Role of dendritic cells in innate and adaptive immune response in human aging. Exp Gerontol. 2014 Jun; 54:47-52. Gupta S. PMID: 24370374.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    49. NF-κB-mediated miR-30b regulation in cardiomyocytes cell death by targeting Bcl-2. Mol Cell Biochem. 2014 Feb; 387(1-2):135-41. Wei C, Li L, Gupta S. PMID: 24178239.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    50. Inflammation & autoimmunity in human ageing: dendritic cells take a center stage. Indian J Med Res. 2013 Nov; 138(5):711-6. Gupta S, Agrawal A. PMID: 24434323; PMCID: PMC3928701.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    51. Tolerance and autoimmunity in primary immunodeficiency disease: a comprehensive review. Clin Rev Allergy Immunol. 2013 Oct; 45(2):162-9. Gupta S, Louis AG. PMID: 23296947.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    52. Dendritic cells from the elderly display an intrinsic defect in the production of IL-10 in response to lithium chloride. Exp Gerontol. 2013 Nov; 48(11):1285-92. Agrawal S, Gollapudi S, Gupta S, Agrawal A. PMID: 23988651.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    53. Circulating miRNAs as potential marker for pulmonary hypertension. PLoS One. 2013; 8(5):e64396. Wei C, Henderson H, Spradley C, Li L, Kim IK, Kumar S, Hong N, Arroliga AC, Gupta S. PMID: 23717609; PMCID: PMC3662705.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    54. Increased activation and cytokine secretion in B cells stimulated with leptin in aged humans. Immun Ageing. 2013 Jan 23; 10(1):3. Gupta S, Agrawal S, Gollapudi S. PMID: 23343052; PMCID: PMC3557206.
      View in: PubMed   Mentions: 18  
    55. Thymosin β4 and cardiac protection: implication in inflammation and fibrosis. Ann N Y Acad Sci. 2012 Oct; 1269:84-91. Gupta S, Kumar S, Sopko N, Qin Y, Wei C, Kim IK. PMID: 23045975.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    56. Impaired secretion of interferons by dendritic cells from aged subjects to influenza : role of histone modifications. Age (Dordr). 2013 Oct; 35(5):1785-97. Prakash S, Agrawal S, Cao JN, Gupta S, Agrawal A. PMID: 23007963; PMCID: PMC3776111.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    57. Increased IL-21 secretion by aged CD4+T cells is associated with prolonged STAT-4 activation and CMV seropositivity. Aging (Albany NY). 2012 Sep; 4(9):648-59. Agrawal A, Su H, Chen J, Osann K, Agrawal S, Gupta S. PMID: 23064011; PMCID: PMC3492228.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    58. Thymosin beta 4 protects cardiomyocytes from oxidative stress by targeting anti-oxidative enzymes and anti-apoptotic genes. PLoS One. 2012; 7(8):e42586. Wei C, Kumar S, Kim IK, Gupta S. PMID: 22880044; PMCID: PMC3411836.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    59. T and B cell deficiency associated with yellow nail syndrome. Scand J Immunol. 2012 Mar; 75(3):329-35. Gupta S, Samra D, Yel L, Agrawal S. PMID: 21995335.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    60. Cardiac-specific genetic inhibition of nuclear factor-κB prevents right ventricular hypertrophy induced by monocrotaline. Am J Physiol Heart Circ Physiol. 2012 Apr 15; 302(8):H1655-66. Kumar S, Wei C, Thomas CM, Kim IK, Seqqat R, Kumar R, Baker KM, Jones WK, Gupta S. PMID: 22245771.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    61. Primary immunodeficiencies in India: a perspective. Ann N Y Acad Sci. 2012 Feb; 1250:73-9. Gupta S, Madkaikar M, Singh S, Sehgal S. PMID: 22224794.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    62. Thymosin beta 4 prevents oxidative stress by targeting antioxidant and anti-apoptotic genes in cardiac fibroblasts. PLoS One. 2011; 6(10):e26912. Kumar S, Gupta S. PMID: 22046407; PMCID: PMC3201979.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    63. Significance of thymosin β4 and implication of PINCH-1-ILK-α-parvin (PIP) complex in human dilated cardiomyopathy. PLoS One. 2011; 6(5):e20184. Sopko N, Qin Y, Finan A, Dadabayev A, Chigurupati S, Qin J, Penn MS, Gupta S. PMID: 21625516; PMCID: PMC3098280.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    64. Leptin activates human B cells to secrete TNF-α, IL-6, and IL-10 via JAK2/STAT3 and p38MAPK/ERK1/2 signaling pathway. J Clin Immunol. 2011 Jun; 31(3):472-8. Agrawal S, Gollapudi S, Su H, Gupta S. PMID: 21243519; PMCID: PMC3132280.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansCells
    65. A farewell. J Clin Immunol. 2010 Nov; 30(6):775-6. Gupta S. PMID: 20953682; PMCID: PMC2970814.
      View in: PubMed   Mentions:    Fields:    
    66. Human dendritic cells activated via dectin-1 are efficient at priming Th17, cytotoxic CD8 T and B cell responses. PLoS One. 2010 Oct 18; 5(10):e13418. Agrawal S, Gupta S, Agrawal A. PMID: 20976143; PMCID: PMC2956651.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    67. Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity. Age (Dordr). 2011 Sep; 33(3):363-76. Sridharan A, Esposo M, Kaushal K, Tay J, Osann K, Agrawal S, Gupta S, Agrawal A. PMID: 20953722; PMCID: PMC3168606.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    68. TLR1/2, TLR7, and TLR9 signals directly activate human peripheral blood naive and memory B cell subsets to produce cytokines, chemokines, and hematopoietic growth factors. J Clin Immunol. 2011 Feb; 31(1):89-98. Agrawal S, Gupta S. PMID: 20821041; PMCID: PMC3064903.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansCells
    69. Impaired functions of peripheral blood monocyte subpopulations in aged humans. J Clin Immunol. 2010 Nov; 30(6):806-13. Nyugen J, Agrawal S, Gollapudi S, Gupta S. PMID: 20703784; PMCID: PMC2970801.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCells
    70. Impact of aging on dendritic cell functions in humans. Ageing Res Rev. 2011 Jul; 10(3):336-45. Agrawal A, Gupta S. PMID: 20619360; PMCID: PMC3030666.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    71. Antibodies: basic mechanisms and emerging concepts. J Clin Immunol. 2010 May; 30 Suppl 1:S1-3. Gupta S. PMID: 20387105; PMCID: PMC2883096.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    72. Adaptive and Innate Immune Responses in Autism: Rationale for Therapeutic Use of Intravenous Immunoglobulin. J Clin Immunol. 2010 May; 30 Suppl 1:S90-6. Gupta S, Samra D, Agrawal S. PMID: 20393790; PMCID: PMC2883089.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    73. Age-associated epigenetic modifications in human DNA increase its immunogenicity. Aging (Albany NY). 2010 Mar 20; 2(2):93-100. Agrawal A, Tay J, Yang GE, Agrawal S, Gupta S. PMID: 20354270; PMCID: PMC2850145.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    74. Impaired pneumovax-23-induced monocyte-derived cytokine production in patients with common variable immunodeficiency. J Clin Immunol. 2010 May; 30(3):435-41. Hong R, Agrawal S, Gollapudi S, Gupta S. PMID: 20177958.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    75. Age-related alterations of gene expression patterns in human CD8+ T cells. Aging Cell. 2010 Feb; 9(1):19-31. Cao JN, Gollapudi S, Sharman EH, Jia Z, Gupta S. PMID: 19878143.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    76. Clinical and immunological features in IgM deficiency. Int Arch Allergy Immunol. 2009; 150(3):291-8. Yel L, Ramanuja S, Gupta S. PMID: 19494527.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    77. Differential effect of human herpesvirus 6A on cell division and apoptosis among naive and central and effector memory CD4+ and CD8+ T-cell subsets. J Virol. 2009 Jun; 83(11):5442-50. Gupta S, Agrawal S, Gollapudi S. PMID: 19297473; PMCID: PMC2681935.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    78. Concurrent upregulation of endogenous proapoptotic and antiapoptotic factors in failing human hearts. Nat Clin Pract Cardiovasc Med. 2009 Mar; 6(3):250-61. Haider N, Arbustini E, Gupta S, Liu H, Narula N, Hajjar R, Moorjani N, Westaby S, Semigran MJ, Dec GW, Chandrashekhar Y, Narula J. PMID: 19234503.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    79. Increased reactivity of dendritic cells from aged subjects to self-antigen, the human DNA. J Immunol. 2009 Jan 15; 182(2):1138-45. Agrawal A, Tay J, Ton S, Agrawal S, Gupta S. PMID: 19124757; PMCID: PMC2621318.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    80. Immune homeostasis: regulatory T cells (Treg) and molecules. J Clin Immunol. 2008 Nov; 28(6):617-8. Gupta S. PMID: 18982430.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    81. Vaccinia virus proteins activate human dendritic cells to induce T cell responses in vitro. Vaccine. 2009 Jan 01; 27(1):88-92. Agrawal S, Gupta S, Agrawal A. PMID: 18977270.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    82. Blockade of NF-kappaB using IkappaB alpha dominant-negative mice ameliorates cardiac hypertrophy in myotrophin-overexpressed transgenic mice. J Mol Biol. 2008 Sep 05; 381(3):559-68. Young D, Popovic ZB, Jones WK, Gupta S. PMID: 18620706; PMCID: PMC2688722.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    83. CD95-mediated apoptosis in naïve, central and effector memory subsets of CD4+ and CD8+ T cells in aged humans. Exp Gerontol. 2008 Apr; 43(4):266-74. Gupta S, Gollapudi S. PMID: 18215485.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    84. Broad and specific caspase inhibitor-induced acute repression of apoptosis in atherosclerotic lesions evaluated by radiolabeled annexin A5 imaging. J Am Coll Cardiol. 2007 Dec 11; 50(24):2305-12. Sarai M, Hartung D, Petrov A, Zhou J, Narula N, Hofstra L, Kolodgie F, Isobe S, Fujimoto S, Vanderheyden JL, Virmani R, Reutelingsperger C, Wong ND, Gupta S, Narula J. PMID: 18068039.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    85. Prevention of cardiac hypertrophy and heart failure by silencing of NF-kappaB. J Mol Biol. 2008 Jan 18; 375(3):637-49. Gupta S, Young D, Maitra RK, Gupta A, Popovic ZB, Yong SL, Mahajan A, Wang Q, Sen S. PMID: 18037434; PMCID: PMC2277468.
      View in: PubMed   Mentions: 63     Fields:    Translation:Animals
    86. Biology of dendritic cells in aging. J Clin Immunol. 2008 Jan; 28(1):14-20. Agrawal A, Agrawal S, Tay J, Gupta S. PMID: 17828583.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    87. Differential sensitivity of naïve and subsets of memory CD4+ and CD8+ T cells to hydrogen peroxide-induced apoptosis. Genes Immun. 2007 Oct; 8(7):560-9. Gupta S, Young T, Yel L, Su H, Gollapudi S. PMID: 17690685.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    88. Effector memory CD8+ T cells are resistant to apoptosis. Ann N Y Acad Sci. 2007 Aug; 1109:145-50. Gupta S, Gollapudi S. PMID: 17785300.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    89. Death of memory T-cell subsets in humans: changes during aging. Expert Rev Clin Immunol. 2007 Jul; 3(4):637-45. Gupta S, Gupta AA. PMID: 20477167.
      View in: PubMed   Mentions: 2     Fields:    
    90. Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway. J Immunol. 2007 Jun 01; 178(11):6912-22. Agrawal A, Agrawal S, Cao JN, Su H, Osann K, Gupta S. PMID: 17513740.
      View in: PubMed   Mentions: 189     Fields:    Translation:HumansCells
    91. Hyperimmunoglobulinemia E syndrome associated with coronary artery aneurysms: deficiency of central memory CD4+ T cells and expansion of effector memory CD4+ T cells. Ann Allergy Asthma Immunol. 2007 Apr; 98(4):389-92. Young TY, Jerome D, Gupta S. PMID: 17458437.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    92. Susceptibility of naïve and subsets of memory T cells to apoptosis via multiple signaling pathways. Autoimmun Rev. 2007 Aug; 6(7):476-81. Gupta S, Gollapudi S. PMID: 17643936.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    93. Arsenic trioxide induces apoptosis via the mitochondrial pathway by upregulating the expression of Bax and Bim in human B cells. Int J Oncol. 2007 Feb; 30(2):313-8. Baysan A, Yel L, Gollapudi S, Su H, Gupta S. PMID: 17203211.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    94. Dendritic cells in human aging. Exp Gerontol. 2007 May; 42(5):421-6. Agrawal A, Agrawal S, Gupta S. PMID: 17182207; PMCID: PMC1909691.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    95. Thimerosal induces TH2 responses via influencing cytokine secretion by human dendritic cells. J Leukoc Biol. 2007 Feb; 81(2):474-82. Agrawal A, Kaushal P, Agrawal S, Gollapudi S, Gupta S. PMID: 17079650.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    96. Differential sensitivity of naïve and memory subsets of human CD8+ T cells to TNF-alpha-induced apoptosis. J Clin Immunol. 2006 May; 26(3):193-203. Gupta S, Su H, Bi R, Gollapudi S. PMID: 16783459.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    97. A paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis. Immun Ageing. 2006 May 19; 3:5. Gupta S, Agrawal A, Agrawal S, Su H, Gollapudi S. PMID: 16712718; PMCID: PMC1475884.
      View in: PubMed   Mentions: 27  
    98. The primary vasculitides: a clinicopathologic correlation. Am J Clin Pathol. 2005 Dec; 124 Suppl:S84-95. Narula N, Gupta S, Narula J. PMID: 16468419.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    99. Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondria. Int J Mol Med. 2005 Dec; 16(6):971-7. Yel L, Brown LE, Su K, Gollapudi S, Gupta S. PMID: 16273274.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    100. TNF-alpha-induced apoptosis in human naïve and memory CD8+ T cells in aged humans. Exp Gerontol. 2006 Jan; 41(1):69-77. Gupta S, Gollapudi S. PMID: 16289923.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    101. Molecular mechanisms of TNF-alpha-induced apoptosis in naïve and memory T cell subsets. Autoimmun Rev. 2006 Apr; 5(4):264-8. Gupta S, Gollapudi S. PMID: 16697967.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    102. Life and death of lymphocytes: a role in immunesenescence. Immun Ageing. 2005 Aug 23; 2:12. Gupta S, Su H, Bi R, Agrawal S, Gollapudi S. PMID: 16115325; PMCID: PMC1236953.
      View in: PubMed   Mentions: 22  
    103. Role of the NF-kappaB signaling cascade and NF-kappaB-targeted genes in failing human hearts. J Mol Med (Berl). 2005 Dec; 83(12):993-1004. Gupta S, Sen S. PMID: 16133425.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    104. Central memory and effector memory subsets of human CD4(+) and CD8(+) T cells display differential sensitivity to TNF-{alpha}-induced apoptosis. Ann N Y Acad Sci. 2005 Jun; 1050:108-14. Gupta S, Bi R, Gollapudi S. PMID: 16014525.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    105. Molecular mechanisms of apoptosis in the cells of the immune system in human aging. Immunol Rev. 2005 Jun; 205:114-29. Gupta S. PMID: 15882349.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    106. Mortals turn me on... J Nucl Med. 2005 Jun; 46(6):906-8. Gupta S, Reutelingsperger C, Narula J. PMID: 15937298.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    107. Axon reactive B cells clonally expanded in the cerebrospinal fluid of patients with multiple sclerosis. J Clin Immunol. 2005 May; 25(3):254-64. Zhang Y, Da RR, Guo W, Ren HM, Hilgenberg LG, Sobel RA, Tourtellotte WW, Smith MA, Olek M, Gupta S, Robertson RT, Nagra R, Van Den Noort S, Qin Y. PMID: 15981091.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    108. Molecular mechanisms of TNF-alpha-induced apoptosis in aging human T cell subsets. Int J Biochem Cell Biol. 2005 May; 37(5):1034-42. Gupta S, Gollapudi S. PMID: 15743676.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    109. Inhibition of NF-kappaB induces regression of cardiac hypertrophy, independent of blood pressure control, in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2005 Jul; 289(1):H20-9. Gupta S, Young D, Sen S. PMID: 15749748.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    110. Role of NF-kappaB signaling pathway in increased tumor necrosis factor-alpha-induced apoptosis of lymphocytes in aged humans. Cell Death Differ. 2005 Feb; 12(2):177-83. Gupta S, Bi R, Kim C, Chiplunkar S, Yel L, Gollapudi S. PMID: 15647756.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    111. Polyclonal B-cell expansion in the cerebrospinal fluid of patients with pseudotumor cerebri. J Clin Immunol. 2004 Nov; 24(6):674-82. Da RR, Kao G, Guo WZ, Olek M, Gupta S, Zhang Y, Van Den Noort S, Qin Y. PMID: 15622452.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    112. Characterization of naïve, memory and effector CD8+ T cells: effect of age. Exp Gerontol. 2004 Apr; 39(4):545-50. Gupta S, Bi R, Su K, Yel L, Chiplunkar S, Gollapudi S. PMID: 15050289.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    113. Cardiac overexpression of myotrophin triggers myocardial hypertrophy and heart failure in transgenic mice. J Biol Chem. 2004 May 07; 279(19):20422-34. Sarkar S, Leaman DW, Gupta S, Sil P, Young D, Morehead A, Mukherjee D, Ratliff N, Sun Y, Rayborn M, Hollyfield J, Sen S. PMID: 14970239.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    114. A role of inhibitor of apoptosis (IAP) proteins in increased lymphocyte apoptosis in aged humans. Mech Ageing Dev. 2004 Feb; 125(2):99-101. Gupta S. PMID: 15037009.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    115. Chronic HIV type 1 infection down-regulates expression of DAP kinase and p19ARF-p53 checkpoint and is associated with resistance to CD95-mediated apoptosis in HUT78 T cells. AIDS Res Hum Retroviruses. 2004 Feb; 20(2):183-9. Kim CH, Chiplunkar S, Gupta S. PMID: 15018706.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    116. Cellular immunodeficiency and autoimmunity in long-term mineral oil administration. Ann Allergy Asthma Immunol. 2004 Jan; 92(1):88-91. Yel L, Chen W, Gupta S. PMID: 14756470.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    117. A role of fas-associated death domain (FADD) in increased apoptosis in aged humans. J Clin Immunol. 2004 Jan; 24(1):24-9. Gupta S, Kim C, Yel L, Gollapudi S. PMID: 14997030.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    118. Severe T- and B-cell immune deficiency associated with malignant thymoma. Ann Allergy Asthma Immunol. 2003 Nov; 91(5):501-5. Yel L, Liao O, Lin F, Gupta S. PMID: 14692437.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    119. Arsenic trioxide induces apoptosis in peripheral blood T lymphocyte subsets by inducing oxidative stress: a role of Bcl-2. Mol Cancer Ther. 2003 Aug; 2(8):711-9. Gupta S, Yel L, Kim D, Kim C, Chiplunkar S, Gollapudi S. PMID: 12939460.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    120. Effect of age on molecular signaling of TNF-alpha-induced apoptosis in human lymphocytes. Mech Ageing Dev. 2003 Apr; 124(4):503-9. Gupta S, Chiplunkar S, Kim C, Yel L, Gollapudi S. PMID: 12714259.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    121. Increased spontaneous, tumor necrosis factor receptor- and CD95 (Fas)-mediated apoptosis in cord blood T-cell subsets from Turner's syndrome. Genes Immun. 2003 Apr; 4(3):239-43. Gupta S, Chiplunkar S, Gupta A, Gollapudi S. PMID: 12700600.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    122. Changes in mitochondrial membrane potential and mitochondrial mass occur independent of the activation of caspase-8 and caspase-3 during CD95-mediated apoptosis in peripheral blood T cells. Int J Oncol. 2003 Mar; 22(3):597-600. Gollapudi S, McCormick MJ, Gupta S. PMID: 12579313.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    123. Molecular basis of rifampicin-induced inhibition of anti-CD95-induced apoptosis of peripheral blood T lymphocytes: the role of CD95 ligand and FLIPs. J Clin Immunol. 2003 Jan; 23(1):11-22. Gollapudi S, Jaidka S, Gupta S. PMID: 12645856.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    124. Molecular signaling in death receptor and mitochondrial pathways of apoptosis (Review). Int J Oncol. 2003 Jan; 22(1):15-20. Gupta S. PMID: 12469180.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    125. Activation of nuclear factor-kappaB is necessary for myotrophin-induced cardiac hypertrophy. J Cell Biol. 2002 Dec 23; 159(6):1019-28. Gupta S, Purcell NH, Lin A, Sen S. PMID: 12486112; PMCID: PMC2173971.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    126. A decision between life and death during TNF-alpha-induced signaling. J Clin Immunol. 2002 Jul; 22(4):185-94. Gupta S. PMID: 12148593.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    127. Myotrophin-kappaB DNA interaction in the initiation process of cardiac hypertrophy. Biochim Biophys Acta. 2002 May 08; 1589(3):247-60. Gupta S, Sen S. PMID: 12031792.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    128. Tumor necrosis factor-alpha-induced apoptosis in T cells from aged humans: a role of TNFR-I and downstream signaling molecules. Exp Gerontol. 2002 Jan-Mar; 37(2-3):293-9. Gupta S. PMID: 11772515.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    129. Molecular steps of tumor necrosis factor receptor-mediated apoptosis. Curr Mol Med. 2001 Jul; 1(3):317-24. Gupta S. PMID: 11899080.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    130. Immunological treatments for autism. J Autism Dev Disord. 2000 Oct; 30(5):475-9. Gupta S. PMID: 11098887.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    131. Molecular and biochemical pathways of apoptosis in lymphocytes from aged humans. Vaccine. 2000 Feb 25; 18(16):1596-601. Gupta S. PMID: 10689134.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    132. A possible role of multidrug resistance-associated protein (MRP) in basic fibroblast growth factor secretion by AIDS-associated Kaposi's sarcoma cells: a survival molecule? J Clin Immunol. 1998 Jul; 18(4):256-63. Gupta S, Aggarwal S, Nakamura S. PMID: 9710742.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    133. Th1- and Th2-like cytokines in CD4+ and CD8+ T cells in autism. J Neuroimmunol. 1998 May 01; 85(1):106-9. Gupta S, Aggarwal S, Rashanravan B, Lee T. PMID: 9627004.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
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