Leman Yel

Title(s)Emeritus Faculty, Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-4566
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    1. Patient experience with subcutaneous immunoglobulin 20%, Ig20Gly, for primary immunodeficiency diseases: a prespecified post hoc analysis of combined data from 2 pivotal trials. BMC Immunol. 2020 05 04; 21(1):24. Meckley LM, Wu Y, Ito D, Berner T, McCoy B, Yel L. PMID: 32366233.
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    2. Safety and tolerability of subcutaneous immunoglobulin 20% in primary immunodeficiency diseases from two continents. Immunotherapy. 2019 08; 11(12):1057-1065. Suez D, Kriván G, Jolles S, Stein M, Gupta S, Paris K, van Hagen PM, Brodszki N, Engl W, Leibl H, McCoy B, Yel L. PMID: 31268374.
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    3. Tolerability of Ig20Gly during onboarding in patients with primary immunodeficiency diseases. Ann Allergy Asthma Immunol. 2019 09; 123(3):271-279.e1. Gupta S, Stein M, Hussain I, Paris K, Engl W, McCoy B, Rabbat CJ, Yel L. PMID: 31228628.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    4. Population pharmacokinetic modeling and simulation of immunoglobulin exposure with varying dosing intervals of subcutaneous immunoglobulin 20% (Ig20Gly) in patients with primary immunodeficiency diseases. Int Immunopharmacol. 2019 Jun; 71:404-410. Dumas T, Berry NS, Wolfsegger M, Jolles S, McCoy B, Yel L. PMID: 30952104.
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    5. Tolerability of subcutaneous immunoglobulin 20%, Ig20Gly, in pediatric patients with primary immunodeficiencies. Immunotherapy. 2019 04; 11(5):397-406. Paris K, Haddad E, Borte M, Brodszki N, Dérfalvi B, Maródi L, Hussain I, Darter A, Engl W, Leibl H, McCoy B, Yel L. PMID: 30626238.
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    6. Response to the Letter to the Editor Regarding "Assessment of Local Adverse Reactions to Subcutaneous Immunoglobulin (SCIG) in Clinical Trials". J Clin Immunol. 2017 11; 37(8):739-740. Suez D, Stein M, Gupta S, Hussain I, Melamed I, Paris K, Darter A, Bourgeois C, Fritsch S, Leibl H, McCoy B, Gelmont D, Yel L. PMID: 28875256.
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    7. Efficacy, safety, tolerability and pharmacokinetics of a novel human immune globulin subcutaneous, 20%: a Phase 2/3 study in Europe in patients with primary immunodeficiencies. Clin Exp Immunol. 2017 Jan; 187(1):146-159. Borte M, Kriván G, Derfalvi B, Maródi L, Harrer T, Jolles S, Bourgeois C, Engl W, Leibl H, McCoy B, Gelmont D, Yel L. PMID: 27613250.
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    8. Efficacy, Safety, and Pharmacokinetics of a Novel Human Immune Globulin Subcutaneous, 20 % in Patients with Primary Immunodeficiency Diseases in North America. J Clin Immunol. 2016 10; 36(7):700-12. Suez D, Stein M, Gupta S, Hussain I, Melamed I, Paris K, Darter A, Bourgeois C, Fritsch S, Leibl H, McCoy B, Gelmont D, Yel L. PMID: 27582171.
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    9. Recombinant human hyaluronidase facilitated subcutaneous immunoglobulin treatment in pediatric patients with primary immunodeficiencies: long-term efficacy, safety and tolerability. Immunotherapy. 2016 10; 8(10):1175-86. Wasserman RL, Melamed I, Kobrynski L, Puck J, Gupta S, Doralt J, Sharkhawy M, Engl W, Leibl H, Gelmont D, Yel L. PMID: 27468136.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    10. Long-Term Tolerability, Safety, and Efficacy of Recombinant Human Hyaluronidase-Facilitated Subcutaneous Infusion of Human Immunoglobulin for Primary Immunodeficiency. J Clin Immunol. 2016 08; 36(6):571-82. Wasserman RL, Melamed I, Stein MR, Engl W, Sharkhawy M, Leibl H, Puck J, Rubinstein A, Kobrynski L, Gupta S, Grant AJ, Ratnayake A, Richmond WG, Church J, Yel L, Gelmont D. PMID: 27220317.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    11. Common variable immunodeficiency associated with microdeletion of chromosome 1q42.1-q42.3 and inositol 1,4,5-trisphosphate kinase B (ITPKB) deficiency. Clin Transl Immunology. 2016 Jan; 5(1):e59. Louis AG, Yel L, Cao JN, Agrawal S, Gupta S. PMID: 26900472.
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    12. A Novel Targeted Screening Tool for Hypogammaglobulinemia: Measurement of Serum Immunoglobulin (IgG, IgM, IgA) Levels from Dried Blood Spots (Ig-DBS Assay). J Clin Immunol. 2015 Aug; 35(6):573-82. Yel L, Rabbat CJ, Cunningham-Rundles C, Orange JS, Torgerson TR, Verbsky JW, Wang Y, Fu M, Robins TS, Edwards MS, Nymann-Andersen J. PMID: 26275445.
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    13. Autoimmunity and inflammation in X-linked agammaglobulinemia. J Clin Immunol. 2014 Aug; 34(6):627-32. Hernandez-Trujillo VP, Scalchunes C, Cunningham-Rundles C, Ochs HD, Bonilla FA, Paris K, Yel L, Sullivan KE. PMID: 24909997.
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    14. Improving patient tolerability in immunoglobulin treatment: focus on stabilizer effects. Expert Rev Clin Immunol. 2013 Jun; 9(6):577-87. Sun A, Teschner W, Yel L. PMID: 23730887.
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    15. T and B cell deficiency associated with yellow nail syndrome. Scand J Immunol. 2012 Mar; 75(3):329-35. Gupta S, Samra D, Yel L, Agrawal S. PMID: 21995335.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    16. H2AX gene does not have a modifier effect on ataxia-telangiectasia phenotype. Int J Immunogenet. 2011 Jun; 38(3):209-13. Mesci L, Ozdag H, Yel L, Ozgur TT, Tan C, Sanal O. PMID: 21199394.
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    17. Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions. Mol Immunol. 2011 Jan; 48(4):610-22. Zan H, Zhang J, Al-Qahtani A, Pone EJ, White CA, Lee D, Yel L, Mai T, Casali P. PMID: 21111482.
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    18. Clinical features of chronic granulomatous disease: a series of 26 patients from a single center. Turk J Pediatr. 2010 Nov-Dec; 52(6):576-81. Turul-Ozgür T, Türkkani-Asal G, Tezcan I, Köker MY, Metin A, Yel L, Ersoy F, Sanal O. PMID: 21428188.
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    19. Selective IgA deficiency. J Clin Immunol. 2010 Jan; 30(1):10-6. Yel L. PMID: 20101521.
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    20. Clinical and immunological features in IgM deficiency. Int Arch Allergy Immunol. 2009; 150(3):291-8. Yel L, Ramanuja S, Gupta S. PMID: 19494527.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    21. Parvovirus B19-induced persistent pure red cell aplasia in a child with T-cell immunodeficiency. Pediatr Hematol Oncol. 2009 Mar; 26(2):63-8. Tavil B, Sanal O, Turul T, Yel L, Gurgey A, Gumruk F. PMID: 19322736.
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    22. Differential sensitivity of naïve and subsets of memory CD4+ and CD8+ T cells to hydrogen peroxide-induced apoptosis. Genes Immun. 2007 Oct; 8(7):560-9. Gupta S, Young T, Yel L, Su H, Gollapudi S. PMID: 17690685.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    23. A case of interleukin-12 receptor beta-1 deficiency with recurrent leishmaniasis. Pediatr Infect Dis J. 2007 Apr; 26(4):366-8. Sanal O, Turkkani G, Gumruk F, Yel L, Secmeer G, Tezcan I, Kara A, Ersoy F. PMID: 17414409.
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    24. Arsenic trioxide induces apoptosis via the mitochondrial pathway by upregulating the expression of Bax and Bim in human B cells. Int J Oncol. 2007 Feb; 30(2):313-8. Baysan A, Yel L, Gollapudi S, Su H, Gupta S. PMID: 17203211.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    25. Health-related quality of life and treatment satisfaction in North American patients with primary immunedeficiency diseases receiving subcutaneous IgG self-infusions at home. J Clin Immunol. 2006 Jan; 26(1):65-72. Nicolay U, Kiessling P, Berger M, Gupta S, Yel L, Roifman CM, Gardulf A, Eichmann F, Haag S, Massion C, Ochs HD. PMID: 16418804.
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    26. Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondria. Int J Mol Med. 2005 Dec; 16(6):971-7. Yel L, Brown LE, Su K, Gollapudi S, Gupta S. PMID: 16273274.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    27. Role of NF-kappaB signaling pathway in increased tumor necrosis factor-alpha-induced apoptosis of lymphocytes in aged humans. Cell Death Differ. 2005 Feb; 12(2):177-83. Gupta S, Bi R, Kim C, Chiplunkar S, Yel L, Gollapudi S. PMID: 15647756.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    28. Molecular analysis of a large cohort of patients with the hyper immunoglobulin M (IgM) syndrome. Blood. 2005 Mar 01; 105(5):1881-90. Lee WI, Torgerson TR, Schumacher MJ, Yel L, Zhu Q, Ochs HD. PMID: 15358621.
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    29. Defective anti-polysaccharide antibody response in patients with ataxia-telangiectasia. Turk J Pediatr. 2004 Jul-Sep; 46(3):208-13. Sanal O, Ozbas-Gerçeker F, Yel L, Ersoy F, Tezcan I, Berkel AI, Metin A, Gatti RA. PMID: 15503472.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    30. Antibody response to a seven-valent pneumococcal conjugated vaccine in patients with ataxia-telangiectasia. J Clin Immunol. 2004 Jul; 24(4):411-7. Sanal O, Ersoy F, Tezcan I, Metin A, Turul T, Gariboglu S, Yel L. PMID: 15163897.
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    31. Characterization of naïve, memory and effector CD8+ T cells: effect of age. Exp Gerontol. 2004 Apr; 39(4):545-50. Gupta S, Bi R, Su K, Yel L, Chiplunkar S, Gollapudi S. PMID: 15050289.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    32. Cellular immunodeficiency and autoimmunity in long-term mineral oil administration. Ann Allergy Asthma Immunol. 2004 Jan; 92(1):88-91. Yel L, Chen W, Gupta S. PMID: 14756470.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    33. A role of fas-associated death domain (FADD) in increased apoptosis in aged humans. J Clin Immunol. 2004 Jan; 24(1):24-9. Gupta S, Kim C, Yel L, Gollapudi S. PMID: 14997030.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    34. Severe T- and B-cell immune deficiency associated with malignant thymoma. Ann Allergy Asthma Immunol. 2003 Nov; 91(5):501-5. Yel L, Liao O, Lin F, Gupta S. PMID: 14692437.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    35. Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination. Nat Immunol. 2003 Oct; 4(10):1023-8. Imai K, Slupphaug G, Lee WI, Revy P, Nonoyama S, Catalan N, Yel L, Forveille M, Kavli B, Krokan HE, Ochs HD, Fischer A, Durandy A. PMID: 12958596.
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    36. Arsenic trioxide induces apoptosis in peripheral blood T lymphocyte subsets by inducing oxidative stress: a role of Bcl-2. . 2003 Aug; 2(8):711-9. Gupta S, Yel L, Kim D, Kim C, Chiplunkar S, Gollapudi S. PMID: 12939460.
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    37. Effect of age on molecular signaling of TNF-alpha-induced apoptosis in human lymphocytes. Mech Ageing Dev. 2003 Apr; 124(4):503-9. Gupta S, Chiplunkar S, Kim C, Yel L, Gollapudi S. PMID: 12714259.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    38. Biochemical and molecular basis of thimerosal-induced apoptosis in T cells: a major role of mitochondrial pathway. Genes Immun. 2002 Aug; 3(5):270-8. Makani S, Gollapudi S, Yel L, Chiplunkar S, Gupta S. PMID: 12140745.
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    39. Griscelli disease: genotype-phenotype correlation in an array of clinical heterogeneity. J Clin Immunol. 2002 Jul; 22(4):237-43. Sanal O, Ersoy F, Tezcan I, Metin A, Yel L, Ménasché G, Gürgey A, Berkel I, de Saint Basile G. PMID: 12148598.
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    40. T-ALL with monoclonal gammopathy and hairy cell features. Am J Hematol. 2000 Oct; 65(2):166-70. Yetgin S, Olcay L, Yel L, Tuncer M, Tezcan I, Erdemli E, Oner AF, Behm FG. PMID: 10996836.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    41. An allelic variant of Griscelli disease: presentation with severe hypotonia, mental-motor retardation, and hypopigmentation consistent with Elejalde syndrome (neuroectodermal melanolysosomal disorder). J Neurol. 2000 Jul; 247(7):570-2. Sanal O, Yel L, Kucukali T, Gilbert-Barnes E, Tardieu M, Texcan I, Ersoy F, Metin A, de Saint Basile G. PMID: 10993506.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    42. Isolated cutaneous response to granulocyte-monocyte colony stimulating factor in fatal idiopathic disseminated Bacillus-Calmette-Guerin infection. Eur J Pediatr. 2000 Mar; 159(3):149-52. Sanal O, Morgan G, Göçmen A, Novelli V, Klein N, Tezcan I, Ersoy F, Berkel AI, Yel L. PMID: 10664224.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    43. TNF-alpha-induced apoptosis in neonatal lymphocytes: TNFRp55 expression and downstream pathways of apoptosis. Genes Immun. 2000; 1(4):271-9. Aggarwal S, Gollapudi S, Yel L, Gupta AS, Gupta S. PMID: 11196704.
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    44. Cartilage-hair hypoplasia syndrome: increased apoptosis of T lymphocytes is associated with altered expression of Fas (CD95), FasL (CD95L), IAP, Bax, and Bcl2. J Clin Immunol. 1999 Nov; 19(6):428-34. Yel L, Aggarwal S, Gupta S. PMID: 10634217.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    45. Bronchiectasis due to ciliary aplasia in Turner's syndrome. Turk J Pediatr. 1999 Oct-Dec; 41(4):525-9. Ozçelik U, Tuncel M, Göçmen A, Balci S, Erbil M, Yel L, Kiper N. PMID: 10770124.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    46. Impaired IgG antibody production to pneumococcal polysaccharides in patients with ataxia-telangiectasia. J Clin Immunol. 1999 Sep; 19(5):326-34. Sanal O, Ersoy F, Yel L, Tezcan I, Metin A, Ozyürek H, Gariboglu S, Fikrig S, Berkel AI, Rijkers GT, Zegers BJ. PMID: 10535610.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    47. A case of chronic severe neutropenia: oral findings and consequences of short-term granulocyte colony-stimulating factor treatment. Aust Dent J. 1998 Feb; 43(1):9-13. Hastürk H, Tezcan I, Yel L, Ersoy F, Sanal O, Yamalik N, Berker E. PMID: 9583218.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    48. Defective serum opsonization activity in children aged 6-48 months having acute purulent otitis media. Turk J Pediatr. 1997 Oct-Dec; 39(4):453-7. Tezcan I, Yilmaz Y, Oner F, Yel L, Sanal O, Ersoy F, Onerci M, Berkel AI. PMID: 9433146.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    49. Mutations in the mu heavy-chain gene in patients with agammaglobulinemia. N Engl J Med. 1996 Nov 14; 335(20):1486-93. Yel L, Minegishi Y, Coustan-Smith E, Buckley RH, Trübel H, Pachman LM, Kitchingman GR, Campana D, Rohrer J, Conley ME. PMID: 8890099.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    50. Dyskeratosis congenita: unusual onset with isolated neutropenia at an early age. Acta Paediatr Jpn. 1996 Jun; 38(3):288-90. Yel L, Tezcan I, Sanal O, Ersoy F, Berkel AI. PMID: 8741326.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    51. Homozygous C2 deficiency: association with defective alternative pathway function and immunoglobulin deficiency. Int Arch Allergy Immunol. 1996 Jun; 110(2):195-8. Sanal O, Yel L, Tezcan I, Ersoy F, Berkel AI. PMID: 8645999.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    52. Low expression of T-cell receptor-CD3 complex: a case with a clinical presentation resembling humoral immunodeficiency. Turk J Pediatr. 1996 Jan-Mar; 38(1):81-4. Sanal O, Yel L, Ersoy F, Tezcan I, Berkel AI. PMID: 8819625.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    53. Selective IgA deficiency with unusual features: development of common variable immunodeficiency, Sjögren's syndrome, autoimmune hemolytic anemia and immune thrombocytopenic purpura. Acta Paediatr Jpn. 1995 Aug; 37(4):526-9. Sanal O, Ersoy F, Metin A, Tezcan I, Berkel AI, Yel L. PMID: 7572159.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    54. Bare lymphocyte syndrome with lack of HLA class I and II antigens. Presentation of two cases. Turk J Pediatr. 1995 Apr-Jun; 37(2):141-6. Ersoy F, Sanal O, Tezcan I, Yel L, Metin A. PMID: 7597764.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    55. Oral findings, treatment and follow-up of a case with major aphthous stomatitis (Sutton's disease). J Clin Pediatr Dent. 1994; 19(1):49-53. Yel L, Tezcan I, Hasturk H, Ersoy F, Sanal O, Yavuzyilmaz E. PMID: 7865424.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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