Leman Yel

Title(s)Emeritus Faculty, Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-4566
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Steady-State Serum IgG Trough Levels Are Adequate for Pharmacokinetic Assessment in Patients with Immunodeficiencies Receiving Subcutaneous Immune Globulin. J Clin Immunol. 2021 May 26. Li Z, McCoy B, Engl W, Yel L. PMID: 34036490.
      View in: PubMed   Mentions:    Fields:    
    2. Patient experience with subcutaneous immunoglobulin 20%, Ig20Gly, for primary immunodeficiency diseases: a prespecified post hoc analysis of combined data from 2 pivotal trials. BMC Immunol. 2020 05 04; 21(1):24. Meckley LM, Wu Y, Ito D, Berner T, McCoy B, Yel L. PMID: 32366233.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Safety and tolerability of subcutaneous immunoglobulin 20% in primary immunodeficiency diseases from two continents. Immunotherapy. 2019 08; 11(12):1057-1065. Suez D, Kriván G, Jolles S, Stein M, Gupta S, Paris K, van Hagen PM, Brodszki N, Engl W, Leibl H, McCoy B, Yel L. PMID: 31268374.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    4. Tolerability of Ig20Gly during onboarding in patients with primary immunodeficiency diseases. Ann Allergy Asthma Immunol. 2019 09; 123(3):271-279.e1. Gupta S, Stein M, Hussain I, Paris K, Engl W, McCoy B, Rabbat CJ, Yel L. PMID: 31228628.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    5. Population pharmacokinetic modeling and simulation of immunoglobulin exposure with varying dosing intervals of subcutaneous immunoglobulin 20% (Ig20Gly) in patients with primary immunodeficiency diseases. Int Immunopharmacol. 2019 Jun; 71:404-410. Dumas T, Berry NS, Wolfsegger M, Jolles S, McCoy B, Yel L. PMID: 30952104.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Tolerability of subcutaneous immunoglobulin 20%, Ig20Gly, in pediatric patients with primary immunodeficiencies. Immunotherapy. 2019 04; 11(5):397-406. Paris K, Haddad E, Borte M, Brodszki N, Dérfalvi B, Maródi L, Hussain I, Darter A, Engl W, Leibl H, McCoy B, Yel L. PMID: 30626238.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    7. Response to the Letter to the Editor Regarding "Assessment of Local Adverse Reactions to Subcutaneous Immunoglobulin (SCIG) in Clinical Trials". J Clin Immunol. 2017 11; 37(8):739-740. Suez D, Stein M, Gupta S, Hussain I, Melamed I, Paris K, Darter A, Bourgeois C, Fritsch S, Leibl H, McCoy B, Gelmont D, Yel L. PMID: 28875256.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Efficacy, Safety, and Pharmacokinetics of a Novel Human Immune Globulin Subcutaneous, 20 % in Patients with Primary Immunodeficiency Diseases in North America. J Clin Immunol. 2016 10; 36(7):700-12. Suez D, Stein M, Gupta S, Hussain I, Melamed I, Paris K, Darter A, Bourgeois C, Fritsch S, Leibl H, McCoy B, Gelmont D, Yel L. PMID: 27582171.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    9. Recombinant human hyaluronidase facilitated subcutaneous immunoglobulin treatment in pediatric patients with primary immunodeficiencies: long-term efficacy, safety and tolerability. Immunotherapy. 2016 10; 8(10):1175-86. Wasserman RL, Melamed I, Kobrynski L, Puck J, Gupta S, Doralt J, Sharkhawy M, Engl W, Leibl H, Gelmont D, Yel L. PMID: 27468136.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    10. Long-Term Tolerability, Safety, and Efficacy of Recombinant Human Hyaluronidase-Facilitated Subcutaneous Infusion of Human Immunoglobulin for Primary Immunodeficiency. J Clin Immunol. 2016 08; 36(6):571-82. Wasserman RL, Melamed I, Stein MR, Engl W, Sharkhawy M, Leibl H, Puck J, Rubinstein A, Kobrynski L, Gupta S, Grant AJ, Ratnayake A, Richmond WG, Church J, Yel L, Gelmont D. PMID: 27220317.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCTClinical Trials
    11. Common variable immunodeficiency associated with microdeletion of chromosome 1q42.1-q42.3 and inositol 1,4,5-trisphosphate kinase B (ITPKB) deficiency. Clin Transl Immunology. 2016 Jan; 5(1):e59. Louis AG, Yel L, Cao JN, Agrawal S, Gupta S. PMID: 26900472.
      View in: PubMed   Mentions:
    12. A Novel Targeted Screening Tool for Hypogammaglobulinemia: Measurement of Serum Immunoglobulin (IgG, IgM, IgA) Levels from Dried Blood Spots (Ig-DBS Assay). J Clin Immunol. 2015 Aug; 35(6):573-82. Yel L, Rabbat CJ, Cunningham-Rundles C, Orange JS, Torgerson TR, Verbsky JW, Wang Y, Fu M, Robins TS, Edwards MS, Nymann-Andersen J. PMID: 26275445.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    13. Autoimmunity and inflammation in X-linked agammaglobulinemia. J Clin Immunol. 2014 Aug; 34(6):627-32. Hernandez-Trujillo VP, Scalchunes C, Cunningham-Rundles C, Ochs HD, Bonilla FA, Paris K, Yel L, Sullivan KE. PMID: 24909997.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    14. Improving patient tolerability in immunoglobulin treatment: focus on stabilizer effects. Expert Rev Clin Immunol. 2013 Jun; 9(6):577-87. Sun A, Teschner W, Yel L. PMID: 23730887.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions. Mol Immunol. 2011 Jan; 48(4):610-22. Zan H, Zhang J, Al-Qahtani A, Pone EJ, White CA, Lee D, Yel L, Mai T, Casali P. PMID: 21111482.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    16. Clinical features of chronic granulomatous disease: a series of 26 patients from a single center. Turk J Pediatr. 2010 Nov-Dec; 52(6):576-81. Turul-Ozgür T, Türkkani-Asal G, Tezcan I, Köker MY, Metin A, Yel L, Ersoy F, Sanal O. PMID: 21428188.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    17. Selective IgA deficiency. J Clin Immunol. 2010 Jan; 30(1):10-6. Yel L. PMID: 20101521.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansAnimals
    18. Clinical and immunological features in IgM deficiency. Int Arch Allergy Immunol. 2009; 150(3):291-8. Yel L, Ramanuja S, Gupta S. PMID: 19494527.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    19. Parvovirus B19-induced persistent pure red cell aplasia in a child with T-cell immunodeficiency. Pediatr Hematol Oncol. 2009 Mar; 26(2):63-8. Tavil B, Sanal O, Turul T, Yel L, Gurgey A, Gumruk F. PMID: 19322736.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    20. A case of interleukin-12 receptor beta-1 deficiency with recurrent leishmaniasis. Pediatr Infect Dis J. 2007 Apr; 26(4):366-8. Sanal O, Turkkani G, Gumruk F, Yel L, Secmeer G, Tezcan I, Kara A, Ersoy F. PMID: 17414409.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    21. Arsenic trioxide induces apoptosis via the mitochondrial pathway by upregulating the expression of Bax and Bim in human B cells. Int J Oncol. 2007 Feb; 30(2):313-8. Baysan A, Yel L, Gollapudi S, Su H, Gupta S. PMID: 17203211.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    22. Health-related quality of life and treatment satisfaction in North American patients with primary immunedeficiency diseases receiving subcutaneous IgG self-infusions at home. J Clin Immunol. 2006 Jan; 26(1):65-72. Nicolay U, Kiessling P, Berger M, Gupta S, Yel L, Roifman CM, Gardulf A, Eichmann F, Haag S, Massion C, Ochs HD. PMID: 16418804.
      View in: PubMed   Mentions: 69     Fields:    Translation:Humans
    23. Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondria. Int J Mol Med. 2005 Dec; 16(6):971-7. Yel L, Brown LE, Su K, Gollapudi S, Gupta S. PMID: 16273274.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    24. Molecular analysis of a large cohort of patients with the hyper immunoglobulin M (IgM) syndrome. Blood. 2005 Mar 01; 105(5):1881-90. Lee WI, Torgerson TR, Schumacher MJ, Yel L, Zhu Q, Ochs HD. PMID: 15358621.
      View in: PubMed   Mentions: 66     Fields:    Translation:Humans
    25. Antibody response to a seven-valent pneumococcal conjugated vaccine in patients with ataxia-telangiectasia. J Clin Immunol. 2004 Jul; 24(4):411-7. Sanal O, Ersoy F, Tezcan I, Metin A, Turul T, Gariboglu S, Yel L. PMID: 15163897.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCellsCTClinical Trials
    26. Defective anti-polysaccharide antibody response in patients with ataxia-telangiectasia. Turk J Pediatr. 2004 Jul-Sep; 46(3):208-13. Sanal O, Ozbas-Gerçeker F, Yel L, Ersoy F, Tezcan I, Berkel AI, Metin A, Gatti RA. PMID: 15503472.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    27. Characterization of naïve, memory and effector CD8+ T cells: effect of age. Exp Gerontol. 2004 Apr; 39(4):545-50. Gupta S, Bi R, Su K, Yel L, Chiplunkar S, Gollapudi S. PMID: 15050289.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    28. Cellular immunodeficiency and autoimmunity in long-term mineral oil administration. Ann Allergy Asthma Immunol. 2004 Jan; 92(1):88-91. Yel L, Chen W, Gupta S. PMID: 14756470.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    29. A role of fas-associated death domain (FADD) in increased apoptosis in aged humans. J Clin Immunol. 2004 Jan; 24(1):24-9. Gupta S, Kim C, Yel L, Gollapudi S. PMID: 14997030.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    30. Severe T- and B-cell immune deficiency associated with malignant thymoma. Ann Allergy Asthma Immunol. 2003 Nov; 91(5):501-5. Yel L, Liao O, Lin F, Gupta S. PMID: 14692437.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    31. Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination. Nat Immunol. 2003 Oct; 4(10):1023-8. Imai K, Slupphaug G, Lee WI, Revy P, Nonoyama S, Catalan N, Yel L, Forveille M, Kavli B, Krokan HE, Ochs HD, Fischer A, Durandy A. PMID: 12958596.
      View in: PubMed   Mentions: 186     Fields:    Translation:HumansAnimalsCells
    32. Arsenic trioxide induces apoptosis in peripheral blood T lymphocyte subsets by inducing oxidative stress: a role of Bcl-2. . 2003 Aug; 2(8):711-9. Gupta S, Yel L, Kim D, Kim C, Chiplunkar S, Gollapudi S. PMID: 12939460.
      View in: PubMed   Mentions:
    33. Effect of age on molecular signaling of TNF-alpha-induced apoptosis in human lymphocytes. Mech Ageing Dev. 2003 Apr; 124(4):503-9. Gupta S, Chiplunkar S, Kim C, Yel L, Gollapudi S. PMID: 12714259.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    34. Griscelli disease: genotype-phenotype correlation in an array of clinical heterogeneity. J Clin Immunol. 2002 Jul; 22(4):237-43. Sanal O, Ersoy F, Tezcan I, Metin A, Yel L, Ménasché G, Gürgey A, Berkel I, de Saint Basile G. PMID: 12148598.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
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