Brian Paegel • UCI Profiles

Brian Matthew Paegel

Title(s)	Professor, Pharmaceutical Sciences
School	School of Pharmacy and Pharmaceutical Sciences
Address	101 Theory, Suite 100 Irvine CA 92697-3958
Phone	(949) 824-9368
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Research

research activities and funding

Activity-Based DNA-Encoded Library Technology
NIH R35GM140890Apr 1, 2021 - Jan 31, 2026
Role: Principal Investigator

Polarization-Activated Droplet Sorting
NIH R21EB024116Apr 15, 2017 - Aug 2, 2019
Role: Principal Investigator

High-Throughput Droplet-Scale Functional Screening of DNA-Encoded Combinatorial Libraries
NIH R01GM120491Apr 1, 2017 - Jan 31, 2021
Role: Principal Investigator

Evolving and Engineering New Protease Tools for Mass Spectrometry Proteomics
NIH DP2OD008535Sep 30, 2011 - Jun 30, 2016
Role: Principal Investigator

Microfluidic Processors for Directed Evolution and Synthetic Biology
NIH R00GM083155Dec 1, 2007 - Nov 30, 2011
Role: Principal Investigator

Microfluidic Processors for Directed Evolution and Synthetic Biology
NIH K99GM083155Dec 1, 2007 - Nov 30, 2008
Role: Principal Investigator

Quantitative Microfluidic Molecular Evolution
NIH F32GM073438Feb 1, 2005 - Jan 31, 2007
Role: Principal Investigator

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Solid-phase DNA-encoded library synthesis: a master builder's instructions. Nat Protoc. 2025 May 22. Dixit A, Paegel BM. PMID: 40404924.

View in: PubMed Mentions: Fields:
Cli Clinical Laboratory Techniques Sci Science
Activity-Based DNA-Encoded Library Screening for Selective Inhibitors of Eukaryotic Translation. ACS Cent Sci. 2024 Oct 23; 10(10):1960-1968. Barhoosh H, Dixit A, Cochrane WG, Cavett V, Prince RN, Blair BO, Ward FR, McClure KF, Patten PA, Paulick MG, Paegel BM. PMID: 39463829; PMCID: PMC11503492.

View in: PubMed Mentions:
Building Block-Centric Approach to DNA-Encoded Library Design. J Chem Inf Model. 2024 Jun 24; 64(12):4661-4672. Fitzgerald PR, Dixit A, Zhang C, Mobley DL, Paegel BM. PMID: 38860710; PMCID: PMC11200258.

View in: PubMed Mentions: Fields:
Che Chemistry Med Medical Informatics
Dose-Response Activity-Based DNA-Encoded Library Screening. ACS Med Chem Lett. 2023 Sep 14; 14(9):1295-1303. Fitzgerald PR, Cochrane WG, Paegel BM. PMID: 37736190; PMCID: PMC10510511.

View in: PubMed Mentions: 2
Hydrogel-Encapsulated Beads Enable Proximity-Driven Encoded Library Synthesis and Screening. ACS Cent Sci. 2023 Aug 23; 9(8):1603-1610. Cavett V, Chan AI, Cunningham CN, Paegel BM. PMID: 37637732; PMCID: PMC10451030.

View in: PubMed Mentions: 1
Highly Parallelized Screening of Functionally Enhanced XNA Aptamers in Uniform Hydrogel Particles. ACS Synth Biol. 2023 07 21; 12(7):2127-2134. Yik EJ, Medina E, Paegel BM, Chaput JC. PMID: 37410977.

View in: PubMed Mentions: 3 Fields:
Bio Biotechnology Mol Molecular Biology
Liposomal Permeation Assay for Droplet-Scale Pharmacokinetic Screening. J Med Chem. 2023 05 11; 66(9):6288-6296. Hu J, Chan AI, Adaligil E, Kekessie I, Takahashi M, Song A, Cunningham CN, Paegel BM. PMID: 37075027; PMCID: PMC10184116.

View in: PubMed Mentions: 1 Fields:
Che Chemistry
Translation:Cells
Translating the Genome into Drugs. Acc Chem Res. 2023 02 21; 56(4):489-499. Dixit A, Barhoosh H, Paegel BM. PMID: 36757774; PMCID: PMC9948288.

View in: PubMed Mentions: 6 Fields:
Che Chemistry
Translation:Humans
Study of an RNA-Focused DNA-Encoded Library Informs Design of a Degrader of a r(CUG) Repeat Expansion. J Am Chem Soc. 2022 12 07; 144(48):21972-21979. Gibaut QMR, Akahori Y, Bush JA, Taghavi A, Tanaka T, Aikawa H, Ryan LS, Paegel BM, Disney MD. PMID: 36399603; PMCID: PMC9878440.

View in: PubMed Mentions: 6 Fields:
Che Chemistry
Translation:Humans Cells
DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor. Proc Natl Acad Sci U S A. 2022 02 08; 119(6). Benhamou RI, Suresh BM, Tong Y, Cochrane WG, Cavett V, Vezina-Dawod S, Abegg D, Childs-Disney JL, Adibekian A, Paegel BM, Disney MD. PMID: 35110406; PMCID: PMC8833215.

View in: PubMed Mentions: 16 Fields:
Sci Science
Translation:Humans Cells
Antibacterial Discovery via Phenotypic DNA-Encoded Library Screening. ACS Chem Biol. 2021 12 17; 16(12):2752-2756. Cochrane WG, Fitzgerald PR, Paegel BM. PMID: 34806373; PMCID: PMC8688339.

View in: PubMed Mentions: 11 Fields:
Bio Biochemistry Bio Biology
Translation:Cells
Chiral lipid bilayers are enantioselectively permeable. Nat Chem. 2021 08; 13(8):786-791. Hu J, Cochrane WG, Jones AX, Blackmond DG, Paegel BM. PMID: 34112989; PMCID: PMC8325640.

View in: PubMed Mentions: 9 Fields:
Che Chemistry
DNA-Encoded Chemistry: Drug Discovery from a Few Good Reactions. Chem Rev. 2021 06 23; 121(12):7155-7177. Fitzgerald PR, Paegel BM. PMID: 33044817; PMCID: PMC8345262.

View in: PubMed Mentions: 42 Fields:
Che Chemistry
Multiplexed Enzyme Activity-Based Probe Display via Hybridization. ACS Comb Sci. 2020 11 09; 22(11):579-585. Cavett V, Paegel BM. PMID: 32803953; PMCID: PMC7655629.

View in: PubMed Mentions: 1 Fields:
Che Chemistry
Translation:Cells
Considerations for Achieving Maximized DNA Recovery in Solid-Phase DNA-Encoded Library Synthesis. ACS Comb Sci. 2020 11 09; 22(11):649-655. Price AK, Paegel BM. PMID: 32786319; PMCID: PMC7655546.

View in: PubMed Mentions: Fields:
Che Chemistry
Translation:Cells
Cycloisomerization of Olefins in Water. Angew Chem Int Ed Engl. 2020 07 27; 59(31):12998-13003. Matos JLM, Green SA, Chun Y, Dang VQ, Dushin RG, Richardson P, Chen JS, Piotrowski DW, Paegel BM, Shenvi RA. PMID: 32285542; PMCID: PMC7500246.

View in: PubMed Mentions: 10 Fields:
Che Chemistry
Translation:Cells
Off-DNA DNA-Encoded Library Affinity Screening. ACS Comb Sci. 2020 01 13; 22(1):25-34. Hackler AL, FitzGerald FG, Dang VQ, Satz AL, Paegel BM. PMID: 31829554; PMCID: PMC6957756.

View in: PubMed Mentions: 14 Fields:
Che Chemistry
Translation:Cells
A Solution Phase Platform to Characterize Chemical Reaction Compatibility with DNA-Encoded Chemical Library Synthesis. ACS Comb Sci. 2019 10 14; 21(10):650-655. Ratnayake AS, Flanagan ME, Foley TL, Smith JD, Johnson JG, Bellenger J, Montgomery JI, Paegel BM. PMID: 31425646; PMCID: PMC6938256.

View in: PubMed Mentions: 14 Fields:
Che Chemistry
Translation:Cells
Fluorescence-Activated Droplet Sorting for Single-Cell Directed Evolution. ACS Synth Biol. 2019 06 21; 8(6):1430-1440. Vallejo D, Nikoomanzar A, Paegel BM, Chaput JC. PMID: 31120731; PMCID: PMC6942126.

View in: PubMed Mentions: 40 Fields:
Bio Biotechnology Mol Molecular Biology
Translation:Cells
Activity-Based DNA-Encoded Library Screening. ACS Comb Sci. 2019 05 13; 21(5):425-435. Cochrane WG, Malone ML, Dang VQ, Cavett V, Satz AL, Paegel BM. PMID: 30884226; PMCID: PMC6786493.

View in: PubMed Mentions: 24 Fields:
Che Chemistry
Translation:Cells
Integrated, Continuous Emulsion Creamer. Anal Chem. 2017 12 19; 89(24):13227-13234. Cochrane WG, Hackler AL, Cavett VJ, Price AK, Paegel BM. PMID: 29124927; PMCID: PMC5736441.

View in: PubMed Mentions: 7 Fields:
Che Chemistry Techniques
Poisson Statistics of Combinatorial Library Sampling Predict False Discovery Rates of Screening. ACS Comb Sci. 2017 08 14; 19(8):524-532. MacConnell AB, Paegel BM. PMID: 28682059; PMCID: PMC5558193.

View in: PubMed Mentions: 10 Fields:
Che Chemistry
An Integrated Microfluidic Processor for DNA-Encoded Combinatorial Library Functional Screening. ACS Comb Sci. 2017 03 13; 19(3):181-192. MacConnell AB, Price AK, Paegel BM. PMID: 28199790; PMCID: PMC5350604.

View in: PubMed Mentions: 32 Fields:
Che Chemistry
Translation:Humans Cells
High-throughput Identification of DNA-Encoded IgG Ligands that Distinguish Active and Latent Mycobacterium tuberculosis Infections. ACS Chem Biol. 2017 01 20; 12(1):234-243. Mendes KR, Malone ML, Ndungu JM, Suponitsky-Kroyter I, Cavett VJ, McEnaney PJ, MacConnell AB, Doran TM, Ronacher K, Stanley K, Utset O, Walzl G, Paegel BM, Kodadek T. PMID: 27957856; PMCID: PMC5250564.

View in: PubMed Mentions: 30 Fields:
Bio Biochemistry Bio Biology
Translation:Humans Cells
Evolution of a mass spectrometry-grade protease with PTM-directed specificity. Proc Natl Acad Sci U S A. 2016 12 20; 113(51):14686-14691. Tran DT, Cavett VJ, Dang VQ, Torres HL, Paegel BM. PMID: 27940920; PMCID: PMC5187733.

View in: PubMed Mentions: 16 Fields:
Sci Science
Translation:Humans Cells
Chemoselective Coupling Preserves the Substrate Integrity of Surface-Immobilized Oligonucleotides for Emulsion PCR-Based Gene Library Construction. ACS Comb Sci. 2017 01 09; 19(1):9-14. Malone ML, Cavett VJ, Paegel BM. PMID: 28064476; PMCID: PMC5243130.

View in: PubMed Mentions: 2 Fields:
Che Chemistry
What is a "DNA-Compatible" Reaction? ACS Comb Sci. 2016 Apr 11; 18(4):182-7. Malone ML, Paegel BM. PMID: 26971959; PMCID: PMC4946796.

View in: PubMed Mentions: 70 Fields:
Che Chemistry
hνSABR: Photochemical Dose-Response Bead Screening in Droplets. Anal Chem. 2016 Mar 01; 88(5):2904-11. Price AK, MacConnell AB, Paegel BM. PMID: 26815064; PMCID: PMC4776284.

View in: PubMed Mentions: 19 Fields:
Che Chemistry Techniques
Discovery in Droplets. Anal Chem. 2016 Jan 05; 88(1):339-53. Price AK, Paegel BM. PMID: 26558892; PMCID: PMC4865373.

View in: PubMed Mentions: 20 Fields:
Che Chemistry Techniques
Translation:Humans
DNA-Encoded Solid-Phase Synthesis: Encoding Language Design and Complex Oligomer Library Synthesis. ACS Comb Sci. 2015 Sep 14; 17(9):518-34. MacConnell AB, McEnaney PJ, Cavett VJ, Paegel BM. PMID: 26290177; PMCID: PMC4571006.

View in: PubMed Mentions: 55 Fields:
Che Chemistry
Translation:Cells
Microfluidic bead suspension hopper. Anal Chem. 2014 May 20; 86(10):5039-44. Price AK, MacConnell AB, Paegel BM. PMID: 24761972; PMCID: PMC4029372.

View in: PubMed Mentions: 14 Fields:
Che Chemistry Techniques
Layer-by-layer cell membrane assembly. Nat Chem. 2013 Nov; 5(11):958-63. Matosevic S, Paegel BM. PMID: 24153375; PMCID: PMC4003896.

View in: PubMed Mentions: 49 Fields:
Che Chemistry
Translation:Cells
Stepwise synthesis of giant unilamellar vesicles on a microfluidic assembly line. J Am Chem Soc. 2011 Mar 09; 133(9):2798-800. Matosevic S, Paegel BM. PMID: 21309555; PMCID: PMC3048828.

View in: PubMed Mentions: 51 Fields:
Che Chemistry
Microfluidic landscapes for evolution. Curr Opin Chem Biol. 2010 Oct; 14(5):568-73. Paegel BM. PMID: 20800535; PMCID: PMC2953605.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry
Microfluidic compartmentalized directed evolution. Chem Biol. 2010 Jul 30; 17(7):717-24. Paegel BM, Joyce GF. PMID: 20659684; PMCID: PMC2912841.

View in: PubMed Mentions: 25 Fields:
Bio Biochemistry Bio Biology Che Chemistry
Darwinian evolution on a chip. PLoS Biol. 2008 Apr 08; 6(4):e85. Paegel BM, Joyce GF. PMID: 18399721; PMCID: PMC2288630.

View in: PubMed Mentions: 7 Fields:
Bio Biology
Translation:Cells
Microfluidic serial dilution circuit. Anal Chem. 2006 Nov 01; 78(21):7522-7. Paegel BM, Grover WH, Skelley AM, Mathies RA, Joyce GF. PMID: 17073422; PMCID: PMC2566538.

View in: PubMed Mentions: 11 Fields:
Che Chemistry Techniques
Sparsely cross-linked "nanogel" matrixes as fluid, mechanically stabilized polymer networks for high-throughput microchannel DNA sequencing. Anal Chem. 2004 Sep 15; 76(18):5249-56. Doherty EA, Kan CW, Paegel BM, Yeung SH, Cao S, Mathies RA, Barron AE. PMID: 15362880.

View in: PubMed Mentions: 3 Fields:
Che Chemistry Techniques
Integrated hydrogenated amorphous Si photodiode detector for microfluidic bioanalytical devices. Anal Chem. 2003 Oct 15; 75(20):5300-5. Kamei T, Paegel BM, Scherer JR, Skelley AM, Street RA, Mathies RA. PMID: 14710806.

View in: PubMed Mentions: 9 Fields:
Che Chemistry Techniques
Translation:Cells
Microfluidic devices for DNA sequencing: sample preparation and electrophoretic analysis. Curr Opin Biotechnol. 2003 Feb; 14(1):42-50. Paegel BM, Blazej RG, Mathies RA. PMID: 12566001.

View in: PubMed Mentions: 23 Fields:
Bio Biotechnology
Translation:Cells
Polymorphism ratio sequencing: a new approach for single nucleotide polymorphism discovery and genotyping. Genome Res. 2003 Feb; 13(2):287-93. Blazej RG, Paegel BM, Mathies RA. PMID: 12566407; PMCID: PMC420372.

View in: PubMed Mentions: 6 Fields:
Gen Genetics
Translation:Humans Cells
Microchip bioprocessor for integrated nanovolume sample purification and DNA sequencing. Anal Chem. 2002 Oct 01; 74(19):5092-8. Paegel BM, Yeung SH, Mathies RA. PMID: 12380835.

View in: PubMed Mentions: 6 Fields:
Che Chemistry Techniques
High throughput DNA sequencing with a microfabricated 96-lane capillary array electrophoresis bioprocessor. Proc Natl Acad Sci U S A. 2002 Jan 22; 99(2):574-9. Paegel BM, Emrich CA, Wedemayer GJ, Scherer JR, Mathies RA. PMID: 11792836; PMCID: PMC117347.

View in: PubMed Mentions: 19 Fields:
Sci Science
Translation:Cells
High-pressure gel loader for capillary array electrophoresis microchannel plates. Biotechniques. 2001 Nov; 31(5):1150-2, 1154. Scherer JR, Paegel BM, Wedemayer GJ, Emrich CA, Lo J, Medintz IL, Mathies RA. PMID: 11730021.

View in: PubMed Mentions: 3 Fields:
Bio Biotechnology
High-performance genetic analysis using microfabricated capillary array electrophoresis microplates. Electrophoresis. 2001 Oct; 22(18):3845-56. Medintz IL, Paegel BM, Blazej RG, Emrich CA, Berti L, Scherer JR, Mathies RA. PMID: 11700713.

View in: PubMed Mentions: 4 Fields:
Che Chemistry Techniques
Translation:Humans
Microfabricated capillary array electrophoresis DNA analysis systems. J Chromatogr A. 2001 Jul 27; 924(1-2):265-70. Medintz IL, Paegel BM, Mathies RA. PMID: 11521873.

View in: PubMed Mentions: 4 Fields:
Che Chemistry Techniques
Translation:Humans Cells
Turn geometry for minimizing band broadening in microfabricated capillary electrophoresis channels. Anal Chem. 2000 Jul 15; 72(14):3030-7. Paegel BM, Hutt LD, Simpson PC, Mathies RA. PMID: 10939363.

View in: PubMed Mentions: 7 Fields:
Che Chemistry Techniques
Translation:Cells