Gulab Zode

Title(s)Professor, Ophthalmology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-4366
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    Collapse Biography 
    Collapse Education and Training
    University of North Texas HSC, Fort WorthPhd08/2008cell biology
    Collapse Awards and Honors
    Alcon labs2023Alcon Senior Scientist Award from Alcon Research Institute, Fort Worth, Tx
    UNTHSC2021Nominated for TEMES award (recognizing outstanding researcher in Texas)
    UNTHSC2018Subrecipient of Lewis Rudin Glaucoma Prize
    UNTHSC2018Rising Star Innovation Award, University of North Texas Health Sci. Ctr.
    NEI2012NIH Pathway to Independence Award
    American Society of Human Genetics 2011Semifinalist for Trainee Research Award
    University of Iowa, IA2011First Prize in poster presentation
    UNTHSC2007First prize for oral presentation at Research Appreciation Day
    ARVO2007Wood Balkema Memorial Travel Grant for excellence in research
    UNTHSC2007Rachel Dauphin Memorial Scholarship for excellence in research
    UNTHSC2006Third prize in poster presentation at Research Appreciation Day

    Collapse Overview 
    Collapse Overview
    My laboratory is interested in understanding the pathological mechanisms involved in glaucomatous damage to trabecular meshwork (TM) and retinal ganglion cells (RGCs). Our primary focus is to understand the role of protein misfolding and its associated cellular processes including endoplasmic reticulum (ER) stress and autophagy/mitophagy in the glaucomatous TM damage and RGCs loss. Our long-term goal is to develop novel glaucoma treatment by targeting these pathologies via small molecule or genome editing methods.

    Collapse Research 
    Collapse Research Activities and Funding
    Non-Viral Delivery Methods of Genome Editing for the Treatment of Glaucoma
    Alcon Research Institute Aug 1, 2023 - Jul 30, 2026
    Role: PI
    Development and characterization of an inducible model for myocilin POAG
    NEI R21 EY034333Aug 1, 2023 - Jul 30, 2025
    Role: PI
    Impaired TRVP4-eNOS signaling in TM contributes to glaucoma
    NIH R01EY034238Sep 1, 2022 - Jun 30, 2027
    Role: Principal Investigator
    Novel Genome Editing for the Treatment of Glaucoma
    NIH R01EY030366Jul 1, 2019 - Apr 30, 2024
    Role: Principal Investigator
    Crosstalk Between Unfolded Protein Response and Autophagy for the Treatment of Glaucoma
    NIH R01EY026177Mar 1, 2016 - Apr 30, 2026
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Genetic and pharmacological correction of impaired mitophagy in retinal ganglion cells rescues glaucomatous neurodegeneration. bioRxiv. 2025 Feb 15. Maddineni P, Kodati B, Kaipa BR, Kesavan K, Cameron Millar J, Yacoub S, Kasetti RB, Clark AF, Zode GS. PMID: 39990391; PMCID: PMC11844533.
      View in: PubMed   Mentions:
    2. Impaired axonal transport contributes to neurodegeneration in a Cre-inducible mouse model of myocilin-associated glaucoma. JCI Insight. 2025 Jan 21; 10(5). Kaipa BR, Kasetti R, Sundaresan Y, Li L, Yacoub S, Millar JC, Cho W, Skowronska-Krawczyk D, Maddineni P, Palczewski K, Zode GS. PMID: 39836483.
      View in: PubMed   Mentions:    Fields:    
    3. Mouse Model of Glucocorticoid-Induced Glaucoma. Methods Mol Biol. 2025; 2858:131-141. Maddineni P, Sundaresan Y, Zode G. PMID: 39433673.
      View in: PubMed   Mentions:    Fields:    
    4. A Reduction in Mitophagy Is Associated with Glaucomatous Neurodegeneration in Rodent Models of Glaucoma. Int J Mol Sci. 2024 Dec 04; 25(23). Chaphalkar RM, Kodati B, Maddineni P, He S, Brooks CD, Stankowska DL, Yang S, Zode G, Krishnamoorthy RR. PMID: 39684751; PMCID: PMC11642561.
      View in: PubMed   Mentions:    Fields:    
    5. Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches. Invest Ophthalmol Vis Sci. 2024 Dec 02; 65(14):32. Acott TS, Fautsch MP, Mao W, Ethier CR, Huang AS, Kelley MJ, Aga M, Bhattacharya SK, Borras T, Bovenkamp D, Chowdhury UR, Clark AF, Dibas MI, Du Y, Elliott MH, Faralli JA, Gong H, Herberg S, Johnstone MA, Kaufman PL, Keller KE, Kelly RA, Krizaj D, Kuehn MH, Li HL, Lieberman R, Lin SC, Liu Y, McDonnell FS, McDowell CM, McLellan GJ, Mzyk P, Nair KS, Overby DR, Peters DM, Raghunathan V, Rao PV, Roddy GW, Sharif NA, Shim MS, Sun Y, Thomson BR, Toris CB, Willoughby CE, Zhang HF, Freddo TF, Fuchshofer R, Hill KR, Karimi A, Kizhatil K, Kopcyznski CC, Liton P, Patel G, Peng M, Pattabiraman PP, Prasanna G, Reina-Torres E, Samples EG, Samples JR, Steel CL, Strohmaier CA, Subramanian P, Sugali CK, van Batenburg-Sherwood J, Wong C, Youngblood H, Zode GS, White E, Stamer WD. PMID: 39693082; PMCID: PMC11708870.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    6. Impaired axonal transport at the optic nerve head contributes to neurodegeneration in a novel Cre-inducible mouse model of myocilin glaucoma. bioRxiv. 2024 Nov 02. Kaipa BR, Kasetti R, Sundaresan Y, Li L, Yacoub S, Millar C, Cho W, Skowronska-Krawczyk D, Maddineni P, Palczewski K, Zode G. PMID: 39345520; PMCID: PMC11429981.
      View in: PubMed   Mentions:
    7. Lentiviral mediated delivery of CRISPR/Cas9 reduces intraocular pressure in a mouse model of myocilin glaucoma. Sci Rep. 2024 03 23; 14(1):6958. Patil SV, Kaipa BR, Ranshing S, Sundaresan Y, Millar JC, Nagarajan B, Kiehlbauch C, Zhang Q, Jain A, Searby CC, Scheetz TE, Clark AF, Sheffield VC, Zode GS. PMID: 38521856; PMCID: PMC10960846.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    8. Steroid-Induced Ocular Hypertension in Mice Is Differentially Reduced by Selective EP2, EP3, EP4, and IP Prostanoid Receptor Agonists. Int J Mol Sci. 2024 Mar 15; 25(6). Sharif NA, Millar JC, Zode G, Ota T. PMID: 38542305; PMCID: PMC10970031.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    9. Lentiviral mediated delivery of CRISPR/Cas9 reduces intraocular pressure in a mouse model of myocilin glaucoma. Res Sq. 2023 Dec 19. Patil SV, Kaipa BR, Ranshing S, Sundaresan Y, Millar JC, Nagarajan B, Kiehlbauch C, Zhang Q, Jain A, Searby CC, Scheetz TE, Clark AF, Sheffield VC, Zode GS. PMID: 38196579; PMCID: PMC10775399.
      View in: PubMed   Mentions:
    10. Modulation of Mitochondrial Metabolic Parameters and Antioxidant Enzymes in Healthy and Glaucomatous Trabecular Meshwork Cells with Hybrid Small Molecule SA-2. Int J Mol Sci. 2023 Jul 17; 24(14). Amankwa CE, Young O, DebNath B, Gondi SR, Rangan R, Ellis DZ, Zode G, Stankowska DL, Acharya S. PMID: 37511316; PMCID: PMC10380487.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    11. Therapeutic applications of CRISPR/Cas9 gene editing technology for the treatment of ocular diseases. FEBS J. 2023 Nov; 290(22):5248-5269. Sundaresan Y, Yacoub S, Kodati B, Amankwa CE, Raola A, Zode G. PMID: 36877952; PMCID: PMC10480348.
      View in: PubMed   Mentions: 3     Fields:    
    12. Viral Vector-Induced Ocular Hypertension in Mice. Methods Mol Biol. 2023; 2708:77-97. Millar JC, Sundaresan Y, Zode GS, Clark AF. PMID: 37558962.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    13. A Novel Mouse Model of TGFβ2-Induced Ocular Hypertension Using Lentiviral Gene Delivery. Int J Mol Sci. 2022 Jun 21; 23(13). Patil SV, Kasetti RB, Millar JC, Zode GS. PMID: 35805889; PMCID: PMC9266301.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    14. Neogenin pathway positively regulates fibronectin production by glomerular mesangial cells. Am J Physiol Cell Physiol. 2022 07 01; 323(1):C226-C235. Chaudhari S, Yazdizadeh Shotorbani P, Tao Y, Kasetti R, Zode G, Mathis KW, Ma R. PMID: 35704698; PMCID: PMC9273264.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    15. Enhanced Orai1-mediated store-operated Ca2+ channel/calpain signaling contributes to high glucose-induced podocyte injury. J Biol Chem. 2022 06; 298(6):101990. Tao Y, Chaudhari S, Shotorbani PY, Ding Y, Chen Z, Kasetti R, Zode G, Ma R. PMID: 35490782; PMCID: PMC9136128.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    16. Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms. Invest Ophthalmol Vis Sci. 2022 02 01; 63(2):12. McDowell CM, Kizhatil K, Elliott MH, Overby DR, van Batenburg-Sherwood J, Millar JC, Kuehn MH, Zode G, Acott TS, Anderson MG, Bhattacharya SK, Bertrand JA, Borras T, Bovenkamp DE, Cheng L, Danias J, De Ieso ML, Du Y, Faralli JA, Fuchshofer R, Ganapathy PS, Gong H, Herberg S, Hernandez H, Humphries P, John SWM, Kaufman PL, Keller KE, Kelley MJ, Kelly RA, Krizaj D, Kumar A, Leonard BC, Lieberman RL, Liton P, Liu Y, Liu KC, Lopez NN, Mao W, Mavlyutov T, McDonnell F, McLellan GJ, Mzyk P, Nartey A, Pasquale LR, Patel GC, Pattabiraman PP, Peters DM, Raghunathan V, Rao PV, Rayana N, Raychaudhuri U, Reina-Torres E, Ren R, Rhee D, Chowdhury UR, Samples JR, Samples EG, Sharif N, Schuman JS, Sheffield VC, Stevenson CH, Soundararajan A, Subramanian P, Sugali CK, Sun Y, Toris CB, Torrejon KY, Vahabikashi A, Vranka JA, Wang T, Willoughby CE, Xin C, Yun H, Zhang HF, Fautsch MP, Tamm ER, Clark AF, Ethier CR, Stamer WD. PMID: 35129590; PMCID: PMC8842499.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    17. Sodium 4-Phenylbutyrate Reduces Ocular Hypertension by Degrading Extracellular Matrix Deposition via Activation of MMP9. Int J Mol Sci. 2021 Sep 18; 22(18). Maddineni P, Kasetti RB, Kodati B, Yacoub S, Zode GS. PMID: 34576258; PMCID: PMC8465971.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    18. GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans. Nat Commun. 2021 08 12; 12(1):4877. Nair KS, Srivastava C, Brown RV, Koli S, Choquet H, Kang HS, Kuo YM, Grimm SA, Sutherland C, Badea A, Johnson GA, Zhao Y, Yin J, Okamoto K, Clark G, Borrás T, Zode G, Kizhatil K, Chakrabarti S, John SWM, Jorgenson E, Jetten AM. PMID: 34385434; PMCID: PMC8361148.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    19. Caveolar peroxynitrite formation impairs endothelial TRPV4 channels and elevates pulmonary arterial pressure in pulmonary hypertension. Proc Natl Acad Sci U S A. 2021 04 27; 118(17). Daneva Z, Marziano C, Ottolini M, Chen YL, Baker TM, Kuppusamy M, Zhang A, Ta HQ, Reagan CE, Mihalek AD, Kasetti RB, Shen Y, Isakson BE, Minshall RD, Zode GS, Goncharova EA, Laubach VE, Sonkusare SK. PMID: 33879616; PMCID: PMC8092599.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    20. Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma. Proc Natl Acad Sci U S A. 2021 04 20; 118(16). Patel PD, Chen YL, Kasetti RB, Maddineni P, Mayhew W, Millar JC, Ellis DZ, Sonkusare SK, Zode GS. PMID: 33853948; PMCID: PMC8072326.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    21. Autophagy stimulation reduces ocular hypertension in a murine glaucoma model via autophagic degradation of mutant myocilin. JCI Insight. 2021 03 08; 6(5). Kasetti RB, Maddineni P, Kiehlbauch C, Patil S, Searby CC, Levine B, Sheffield VC, Zode GS. PMID: 33539326; PMCID: PMC8021112.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    22. ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load. Nat Commun. 2020 11 05; 11(1):5594. Kasetti RB, Patel PD, Maddineni P, Patil S, Kiehlbauch C, Millar JC, Searby CC, Raghunathan V, Sheffield VC, Zode GS. PMID: 33154371; PMCID: PMC7644693.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    23. Fibulin-3 knockout mice demonstrate corneal dysfunction but maintain normal retinal integrity. J Mol Med (Berl). 2020 11; 98(11):1639-1656. Daniel S, Renwick M, Chau VQ, Datta S, Maddineni P, Zode G, Wade EM, Robertson SP, Petroll WM, Hulleman JD. PMID: 32964303; PMCID: PMC7606609.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    24. CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma. Mol Neurodegener. 2020 08 27; 15(1):48. Maddineni P, Kasetti RB, Patel PD, Millar JC, Kiehlbauch C, Clark AF, Zode GS. PMID: 32854767; PMCID: PMC7457267.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    25. Correction: Ex-vivo cultured human corneoscleral segment model to study the effects of glaucoma factors on trabecular meshwork. PLoS One. 2020; 15(8):e0238408. Kasetti RB, Patel PD, Maddineni P, Zode GS. PMID: 32841305; PMCID: PMC7447030.
      View in: PubMed   Mentions:    Fields:    
    26. Ex-vivo cultured human corneoscleral segment model to study the effects of glaucoma factors on trabecular meshwork. PLoS One. 2020; 15(6):e0232111. Kasetti RB, Patel PD, Maddineni P, Zode GS. PMID: 32579557; PMCID: PMC7314024.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    27. Mechanisms underlying selective coupling of endothelial Ca2+ signals with eNOS vs. IK/SK channels in systemic and pulmonary arteries. J Physiol. 2020 09; 598(17):3577-3596. Ottolini M, Daneva Z, Chen YL, Cope EL, Kasetti RB, Zode GS, Sonkusare SK. PMID: 32463112; PMCID: PMC7484264.
      View in: PubMed   Mentions: 27     Fields:    
    28. Technical brief: Direct, real-time electrochemical measurement of nitric oxide in ex vivo cultured human corneoscleral segments. Mol Vis. 2020; 26:434-444. Patel PD, Kasetti RB, Sonkusare SK, Zode GS. PMID: 32565671; PMCID: PMC7300198.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    29. Endogenous ocular lipids as potential modulators of intraocular pressure. J Cell Mol Med. 2020 04; 24(7):3856-3900. Edwards G, Arcuri J, Wang H, Ziebarth N, Zode G, Lee RK, Bhattacharya SK. PMID: 32090468; PMCID: PMC7171415.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    30. Zika Virus Infects Trabecular Meshwork and Causes Trabeculitis and Glaucomatous Pathology in Mouse Eyes. mSphere. 2019 05 08; 4(3). Singh PK, Kasetti RB, Zode GS, Goyal A, Juzych MS, Kumar A. PMID: 31068433; PMCID: PMC6506617.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    31. Transforming growth factor β2 (TGFβ2) signaling plays a key role in glucocorticoid-induced ocular hypertension. J Biol Chem. 2018 06 22; 293(25):9854-9868. Kasetti RB, Maddineni P, Patel PD, Searby C, Sheffield VC, Zode GS. PMID: 29743238; PMCID: PMC6016452.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    32. Consensus recommendations for trabecular meshwork cell isolation, characterization and culture. Exp Eye Res. 2018 06; 171:164-173. Keller KE, Bhattacharya SK, Borrás T, Brunner TM, Chansangpetch S, Clark AF, Dismuke WM, Du Y, Elliott MH, Ethier CR, Faralli JA, Freddo TF, Fuchshofer R, Giovingo M, Gong H, Gonzalez P, Huang A, Johnstone MA, Kaufman PL, Kelley MJ, Knepper PA, Kopczynski CC, Kuchtey JG, Kuchtey RW, Kuehn MH, Lieberman RL, Lin SC, Liton P, Liu Y, Lütjen-Drecoll E, Mao W, Masis-Solano M, McDonnell F, McDowell CM, Overby DR, Pattabiraman PP, Raghunathan VK, Rao PV, Rhee DJ, Chowdhury UR, Russell P, Samples JR, Schwartz D, Stubbs EB, Tamm ER, Tan JC, Toris CB, Torrejon KY, Vranka JA, Wirtz MK, Yorio T, Zhang J, Zode GS, Fautsch MP, Peters DM, Acott TS, Stamer WD. PMID: 29526795; PMCID: PMC6042513.
      View in: PubMed   Mentions: 185     Fields:    Translation:HumansAnimals
    33. Glaucomatous cell derived matrices differentially modulate non-glaucomatous trabecular meshwork cellular behavior. Acta Biomater. 2018 04 15; 71:444-459. Raghunathan VK, Benoit J, Kasetti R, Zode G, Salemi M, Phinney BS, Keller KE, Staverosky JA, Murphy CJ, Acott T, Vranka J. PMID: 29524673; PMCID: PMC5899949.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    34. Methods for Analyzing Endoplasmic Reticulum Stress in the Trabecular Meshwork of Glaucoma Models. Methods Mol Biol. 2018; 1695:121-134. Maddineni P, Kasetti RB, Zode GS. PMID: 29190024.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    35. Increased synthesis and deposition of extracellular matrix proteins leads to endoplasmic reticulum stress in the trabecular meshwork. Sci Rep. 2017 11 02; 7(1):14951. Kasetti RB, Maddineni P, Millar JC, Clark AF, Zode GS. PMID: 29097767; PMCID: PMC5668243.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    36. CRISPR-Cas9-based treatment of myocilin-associated glaucoma. Proc Natl Acad Sci U S A. 2017 10 17; 114(42):11199-11204. Jain A, Zode G, Kasetti RB, Ran FA, Yan W, Sharma TP, Bugge K, Searby CC, Fingert JH, Zhang F, Clark AF, Sheffield VC. PMID: 28973933; PMCID: PMC5651749.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    37. Dexamethasone-Induced Ocular Hypertension in Mice: Effects of Myocilin and Route of Administration. Am J Pathol. 2017 Apr; 187(4):713-723. Patel GC, Phan TN, Maddineni P, Kasetti RB, Millar JC, Clark AF, Zode GS. PMID: 28167045; PMCID: PMC5397678.
      View in: PubMed   Mentions: 47     Fields:    Translation:Animals
    38. Expression of Mutant Myocilin Induces Abnormal Intracellular Accumulation of Selected Extracellular Matrix Proteins in the Trabecular Meshwork. Invest Ophthalmol Vis Sci. 2016 Nov 01; 57(14):6058-6069. Kasetti RB, Phan TN, Millar JC, Zode GS. PMID: 27820874; PMCID: PMC5102566.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    39. A Novel Luciferase Assay For Sensitively Monitoring Myocilin Variants in Cell Culture. Invest Ophthalmol Vis Sci. 2016 Apr 01; 57(4):1939-50. Zadoo S, Nguyen A, Zode G, Hulleman JD. PMID: 27092720; PMCID: PMC5110263.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    40. Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma. J Clin Invest. 2015 Aug 03; 125(8):3303. Zode GS, Kuehn MH, Nishimura DY, Searby CC, Mohan K, Grozdanic SD, Bugge K, Anderson MG, Clark AF, Stone EM, Sheffield VC. PMID: 26237042; PMCID: PMC4563763.
      View in: PubMed   Mentions: 23     Fields:    
    41. Increased Endoplasmic Reticulum Stress in Human Glaucomatous Trabecular Meshwork Cells and Tissues. Invest Ophthalmol Vis Sci. 2015 Jun; 56(6):3860-8. Peters JC, Bhattacharya S, Clark AF, Zode GS. PMID: 26066753; PMCID: PMC4468426.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    42. Rat, mouse, and primate models of chronic glaucoma show sustained elevation of extracellular ATP and altered purinergic signaling in the posterior eye. Invest Ophthalmol Vis Sci. 2015 May; 56(5):3075-83. Lu W, Hu H, Sévigny J, Gabelt BT, Kaufman PL, Johnson EC, Morrison JC, Zode GS, Sheffield VC, Zhang X, Laties AM, Mitchell CH. PMID: 26024091; PMCID: PMC4439132.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    43. Mechanosensitive release of adenosine 5'-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: a mechanism for purinergic involvement in chronic strain. Glia. 2014 Sep; 62(9):1486-501. Beckel JM, Argall AJ, Lim JC, Xia J, Lu W, Coffey EE, Macarak EJ, Shahidullah M, Delamere NA, Zode GS, Sheffield VC, Shestopalov VI, Laties AM, Mitchell CH. PMID: 24839011; PMCID: PMC4133947.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    44. Ocular-specific ER stress reduction rescues glaucoma in murine glucocorticoid-induced glaucoma. J Clin Invest. 2014 May; 124(5):1956-65. Zode GS, Sharma AB, Lin X, Searby CC, Bugge K, Kim GH, Clark AF, Sheffield VC. PMID: 24691439; PMCID: PMC4001532.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimals
    45. Topical ocular sodium 4-phenylbutyrate rescues glaucoma in a myocilin mouse model of primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2012 Mar; 53(3):1557-65. Zode GS, Bugge KE, Mohan K, Grozdanic SD, Peters JC, Koehn DR, Anderson MG, Kardon RH, Stone EM, Sheffield VC. PMID: 22328638; PMCID: PMC3339917.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimals
    46. Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma. J Clin Invest. 2011 Sep; 121(9):3542-53. Zode GS, Kuehn MH, Nishimura DY, Searby CC, Mohan K, Grozdanic SD, Bugge K, Anderson MG, Clark AF, Stone EM, Sheffield VC. PMID: 21821918; PMCID: PMC3163970.
      View in: PubMed   Mentions: 177     Fields:    Translation:HumansAnimalsCells
    47. Role of TGFbeta/Smad signaling in gremlin induction of human trabecular meshwork extracellular matrix proteins. Invest Ophthalmol Vis Sci. 2011 Jul 15; 52(8):5251-9. Sethi A, Jain A, Zode GS, Wordinger RJ, Clark AF. PMID: 21642622; PMCID: PMC3176052.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    48. Transforming growth factor-β2 increases extracellular matrix proteins in optic nerve head cells via activation of the Smad signaling pathway. Mol Vis. 2011; 17:1745-58. Zode GS, Sethi A, Brun-Zinkernagel AM, Chang IF, Clark AF, Wordinger RJ. PMID: 21738403; PMCID: PMC3130727.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    49. Bone morphogenetic protein 4 inhibits TGF-beta2 stimulation of extracellular matrix proteins in optic nerve head cells: role of gremlin in ECM modulation. Glia. 2009 May; 57(7):755-66. Zode GS, Clark AF, Wordinger RJ. PMID: 19031438.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    50. Focus on molecules: gremlin. Exp Eye Res. 2008 Aug; 87(2):78-9. Wordinger RJ, Zode G, Clark AF. PMID: 18201700; PMCID: PMC2649704.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    51. Activation of the BMP canonical signaling pathway in human optic nerve head tissue and isolated optic nerve head astrocytes and lamina cribrosa cells. Invest Ophthalmol Vis Sci. 2007 Nov; 48(11):5058-67. Zode GS, Clark AF, Wordinger RJ. PMID: 17962458.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    52. Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma. Invest Ophthalmol Vis Sci. 2007 Mar; 48(3):1191-200. Wordinger RJ, Fleenor DL, Hellberg PE, Pang IH, Tovar TO, Zode GS, Fuller JA, Clark AF. PMID: 17325163.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansCells
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