Gulab Zode

Title(s)Professor, Ophthalmology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
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    1. Therapeutic applications of CRISPR/Cas9 gene editing technology for the treatment of ocular diseases. FEBS J. 2023 Mar 06. Sundaresan Y, Yacoub S, Kodati B, Amankwa CE, Raola A, Zode G. PMID: 36877952.
      View in: PubMed   Mentions:    Fields:    
    2. A Novel Mouse Model of TGFβ2-Induced Ocular Hypertension Using Lentiviral Gene Delivery. Int J Mol Sci. 2022 Jun 21; 23(13). Patil SV, Kasetti RB, Millar JC, Zode GS. PMID: 35805889; PMCID: PMC9266301.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Neogenin pathway positively regulates fibronectin production by glomerular mesangial cells. Am J Physiol Cell Physiol. 2022 07 01; 323(1):C226-C235. Chaudhari S, Yazdizadeh Shotorbani P, Tao Y, Kasetti R, Zode G, Mathis KW, Ma R. PMID: 35704698; PMCID: PMC9273264.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Enhanced Orai1-mediated store-operated Ca2+ channel/calpain signaling contributes to high glucose-induced podocyte injury. J Biol Chem. 2022 06; 298(6):101990. Tao Y, Chaudhari S, Shotorbani PY, Ding Y, Chen Z, Kasetti R, Zode G, Ma R. PMID: 35490782; PMCID: PMC9136128.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    5. Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms. Invest Ophthalmol Vis Sci. 2022 02 01; 63(2):12. McDowell CM, Kizhatil K, Elliott MH, Overby DR, van Batenburg-Sherwood J, Millar JC, Kuehn MH, Zode G, Acott TS, Anderson MG, Bhattacharya SK, Bertrand JA, Borras T, Bovenkamp DE, Cheng L, Danias J, De Ieso ML, Du Y, Faralli JA, Fuchshofer R, Ganapathy PS, Gong H, Herberg S, Hernandez H, Humphries P, John SWM, Kaufman PL, Keller KE, Kelley MJ, Kelly RA, Krizaj D, Kumar A, Leonard BC, Lieberman RL, Liton P, Liu Y, Liu KC, Lopez NN, Mao W, Mavlyutov T, McDonnell F, McLellan GJ, Mzyk P, Nartey A, Pasquale LR, Patel GC, Pattabiraman PP, Peters DM, Raghunathan V, Rao PV, Rayana N, Raychaudhuri U, Reina-Torres E, Ren R, Rhee D, Chowdhury UR, Samples JR, Samples EG, Sharif N, Schuman JS, Sheffield VC, Stevenson CH, Soundararajan A, Subramanian P, Sugali CK, Sun Y, Toris CB, Torrejon KY, Vahabikashi A, Vranka JA, Wang T, Willoughby CE, Xin C, Yun H, Zhang HF, Fautsch MP, Tamm ER, Clark AF, Ethier CR, Stamer WD. PMID: 35129590; PMCID: PMC8842499.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    6. Sodium 4-Phenylbutyrate Reduces Ocular Hypertension by Degrading Extracellular Matrix Deposition via Activation of MMP9. Int J Mol Sci. 2021 Sep 18; 22(18). Maddineni P, Kasetti RB, Kodati B, Yacoub S, Zode GS. PMID: 34576258; PMCID: PMC8465971.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    7. GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans. Nat Commun. 2021 08 12; 12(1):4877. Nair KS, Srivastava C, Brown RV, Koli S, Choquet H, Kang HS, Kuo YM, Grimm SA, Sutherland C, Badea A, Johnson GA, Zhao Y, Yin J, Okamoto K, Clark G, Borrás T, Zode G, Kizhatil K, Chakrabarti S, John SWM, Jorgenson E, Jetten AM. PMID: 34385434; PMCID: PMC8361148.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    8. Caveolar peroxynitrite formation impairs endothelial TRPV4 channels and elevates pulmonary arterial pressure in pulmonary hypertension. Proc Natl Acad Sci U S A. 2021 04 27; 118(17). Daneva Z, Marziano C, Ottolini M, Chen YL, Baker TM, Kuppusamy M, Zhang A, Ta HQ, Reagan CE, Mihalek AD, Kasetti RB, Shen Y, Isakson BE, Minshall RD, Zode GS, Goncharova EA, Laubach VE, Sonkusare SK. PMID: 33879616; PMCID: PMC8092599.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    9. Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma. Proc Natl Acad Sci U S A. 2021 04 20; 118(16). Patel PD, Chen YL, Kasetti RB, Maddineni P, Mayhew W, Millar JC, Ellis DZ, Sonkusare SK, Zode GS. PMID: 33853948; PMCID: PMC8072326.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    10. Autophagy stimulation reduces ocular hypertension in a murine glaucoma model via autophagic degradation of mutant myocilin. JCI Insight. 2021 03 08; 6(5). Kasetti RB, Maddineni P, Kiehlbauch C, Patil S, Searby CC, Levine B, Sheffield VC, Zode GS. PMID: 33539326; PMCID: PMC8021112.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    11. ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load. Nat Commun. 2020 11 05; 11(1):5594. Kasetti RB, Patel PD, Maddineni P, Patil S, Kiehlbauch C, Millar JC, Searby CC, Raghunathan V, Sheffield VC, Zode GS. PMID: 33154371; PMCID: PMC7644693.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    12. Fibulin-3 knockout mice demonstrate corneal dysfunction but maintain normal retinal integrity. J Mol Med (Berl). 2020 11; 98(11):1639-1656. Daniel S, Renwick M, Chau VQ, Datta S, Maddineni P, Zode G, Wade EM, Robertson SP, Petroll WM, Hulleman JD. PMID: 32964303; PMCID: PMC7606609.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    13. CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma. Mol Neurodegener. 2020 08 27; 15(1):48. Maddineni P, Kasetti RB, Patel PD, Millar JC, Kiehlbauch C, Clark AF, Zode GS. PMID: 32854767; PMCID: PMC7457267.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    14. Correction: Ex-vivo cultured human corneoscleral segment model to study the effects of glaucoma factors on trabecular meshwork. PLoS One. 2020; 15(8):e0238408. Kasetti RB, Patel PD, Maddineni P, Zode GS. PMID: 32841305; PMCID: PMC7447030.
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    15. Ex-vivo cultured human corneoscleral segment model to study the effects of glaucoma factors on trabecular meshwork. PLoS One. 2020; 15(6):e0232111. Kasetti RB, Patel PD, Maddineni P, Zode GS. PMID: 32579557; PMCID: PMC7314024.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    16. Mechanisms underlying selective coupling of endothelial Ca2+ signals with eNOS vs. IK/SK channels in systemic and pulmonary arteries. J Physiol. 2020 09; 598(17):3577-3596. Ottolini M, Daneva Z, Chen YL, Cope EL, Kasetti RB, Zode GS, Sonkusare SK. PMID: 32463112; PMCID: PMC7484264.
      View in: PubMed   Mentions: 16     Fields:    
    17. Technical brief: Direct, real-time electrochemical measurement of nitric oxide in ex vivo cultured human corneoscleral segments. Mol Vis. 2020; 26:434-444. Patel PD, Kasetti RB, Sonkusare SK, Zode GS. PMID: 32565671; PMCID: PMC7300198.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    18. Endogenous ocular lipids as potential modulators of intraocular pressure. J Cell Mol Med. 2020 04; 24(7):3856-3900. Edwards G, Arcuri J, Wang H, Ziebarth N, Zode G, Lee RK, Bhattacharya SK. PMID: 32090468; PMCID: PMC7171415.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    19. Zika Virus Infects Trabecular Meshwork and Causes Trabeculitis and Glaucomatous Pathology in Mouse Eyes. mSphere. 2019 05 08; 4(3). Singh PK, Kasetti RB, Zode GS, Goyal A, Juzych MS, Kumar A. PMID: 31068433; PMCID: PMC6506617.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    20. Transforming growth factor β2 (TGFβ2) signaling plays a key role in glucocorticoid-induced ocular hypertension. J Biol Chem. 2018 06 22; 293(25):9854-9868. Kasetti RB, Maddineni P, Patel PD, Searby C, Sheffield VC, Zode GS. PMID: 29743238; PMCID: PMC6016452.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    21. Consensus recommendations for trabecular meshwork cell isolation, characterization and culture. Exp Eye Res. 2018 06; 171:164-173. Keller KE, Bhattacharya SK, Borrás T, Brunner TM, Chansangpetch S, Clark AF, Dismuke WM, Du Y, Elliott MH, Ethier CR, Faralli JA, Freddo TF, Fuchshofer R, Giovingo M, Gong H, Gonzalez P, Huang A, Johnstone MA, Kaufman PL, Kelley MJ, Knepper PA, Kopczynski CC, Kuchtey JG, Kuchtey RW, Kuehn MH, Lieberman RL, Lin SC, Liton P, Liu Y, Lütjen-Drecoll E, Mao W, Masis-Solano M, McDonnell F, McDowell CM, Overby DR, Pattabiraman PP, Raghunathan VK, Rao PV, Rhee DJ, Chowdhury UR, Russell P, Samples JR, Schwartz D, Stubbs EB, Tamm ER, Tan JC, Toris CB, Torrejon KY, Vranka JA, Wirtz MK, Yorio T, Zhang J, Zode GS, Fautsch MP, Peters DM, Acott TS, Stamer WD. PMID: 29526795; PMCID: PMC6042513.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimals
    22. Glaucomatous cell derived matrices differentially modulate non-glaucomatous trabecular meshwork cellular behavior. Acta Biomater. 2018 04 15; 71:444-459. Raghunathan VK, Benoit J, Kasetti R, Zode G, Salemi M, Phinney BS, Keller KE, Staverosky JA, Murphy CJ, Acott T, Vranka J. PMID: 29524673; PMCID: PMC5899949.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    23. Methods for Analyzing Endoplasmic Reticulum Stress in the Trabecular Meshwork of Glaucoma Models. Methods Mol Biol. 2018; 1695:121-134. Maddineni P, Kasetti RB, Zode GS. PMID: 29190024.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    24. Increased synthesis and deposition of extracellular matrix proteins leads to endoplasmic reticulum stress in the trabecular meshwork. Sci Rep. 2017 11 02; 7(1):14951. Kasetti RB, Maddineni P, Millar JC, Clark AF, Zode GS. PMID: 29097767; PMCID: PMC5668243.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    25. CRISPR-Cas9-based treatment of myocilin-associated glaucoma. Proc Natl Acad Sci U S A. 2017 10 17; 114(42):11199-11204. Jain A, Zode G, Kasetti RB, Ran FA, Yan W, Sharma TP, Bugge K, Searby CC, Fingert JH, Zhang F, Clark AF, Sheffield VC. PMID: 28973933; PMCID: PMC5651749.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    26. Dexamethasone-Induced Ocular Hypertension in Mice: Effects of Myocilin and Route of Administration. Am J Pathol. 2017 Apr; 187(4):713-723. Patel GC, Phan TN, Maddineni P, Kasetti RB, Millar JC, Clark AF, Zode GS. PMID: 28167045; PMCID: PMC5397678.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    27. Expression of Mutant Myocilin Induces Abnormal Intracellular Accumulation of Selected Extracellular Matrix Proteins in the Trabecular Meshwork. Invest Ophthalmol Vis Sci. 2016 Nov 01; 57(14):6058-6069. Kasetti RB, Phan TN, Millar JC, Zode GS. PMID: 27820874; PMCID: PMC5102566.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    28. A Novel Luciferase Assay For Sensitively Monitoring Myocilin Variants in Cell Culture. Invest Ophthalmol Vis Sci. 2016 Apr 01; 57(4):1939-50. Zadoo S, Nguyen A, Zode G, Hulleman JD. PMID: 27092720; PMCID: PMC5110263.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    29. Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma. J Clin Invest. 2015 Aug 03; 125(8):3303. Zode GS, Kuehn MH, Nishimura DY, Searby CC, Mohan K, Grozdanic SD, Bugge K, Anderson MG, Clark AF, Stone EM, Sheffield VC. PMID: 26237042; PMCID: PMC4563763.
      View in: PubMed   Mentions: 23     Fields:    
    30. Increased Endoplasmic Reticulum Stress in Human Glaucomatous Trabecular Meshwork Cells and Tissues. Invest Ophthalmol Vis Sci. 2015 Jun; 56(6):3860-8. Peters JC, Bhattacharya S, Clark AF, Zode GS. PMID: 26066753; PMCID: PMC4468426.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    31. Rat, mouse, and primate models of chronic glaucoma show sustained elevation of extracellular ATP and altered purinergic signaling in the posterior eye. Invest Ophthalmol Vis Sci. 2015 May; 56(5):3075-83. Lu W, Hu H, Sévigny J, Gabelt BT, Kaufman PL, Johnson EC, Morrison JC, Zode GS, Sheffield VC, Zhang X, Laties AM, Mitchell CH. PMID: 26024091; PMCID: PMC4439132.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    32. Mechanosensitive release of adenosine 5'-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: a mechanism for purinergic involvement in chronic strain. Glia. 2014 Sep; 62(9):1486-501. Beckel JM, Argall AJ, Lim JC, Xia J, Lu W, Coffey EE, Macarak EJ, Shahidullah M, Delamere NA, Zode GS, Sheffield VC, Shestopalov VI, Laties AM, Mitchell CH. PMID: 24839011; PMCID: PMC4133947.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    33. Ocular-specific ER stress reduction rescues glaucoma in murine glucocorticoid-induced glaucoma. J Clin Invest. 2014 May; 124(5):1956-65. Zode GS, Sharma AB, Lin X, Searby CC, Bugge K, Kim GH, Clark AF, Sheffield VC. PMID: 24691439; PMCID: PMC4001532.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimals
    34. Topical ocular sodium 4-phenylbutyrate rescues glaucoma in a myocilin mouse model of primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2012 Mar; 53(3):1557-65. Zode GS, Bugge KE, Mohan K, Grozdanic SD, Peters JC, Koehn DR, Anderson MG, Kardon RH, Stone EM, Sheffield VC. PMID: 22328638; PMCID: PMC3339917.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimals
    35. Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma. J Clin Invest. 2011 Sep; 121(9):3542-53. Zode GS, Kuehn MH, Nishimura DY, Searby CC, Mohan K, Grozdanic SD, Bugge K, Anderson MG, Clark AF, Stone EM, Sheffield VC. PMID: 21821918; PMCID: PMC3163970.
      View in: PubMed   Mentions: 160     Fields:    Translation:HumansAnimalsCells
    36. Role of TGFbeta/Smad signaling in gremlin induction of human trabecular meshwork extracellular matrix proteins. Invest Ophthalmol Vis Sci. 2011 Jul 15; 52(8):5251-9. Sethi A, Jain A, Zode GS, Wordinger RJ, Clark AF. PMID: 21642622; PMCID: PMC3176052.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    37. Transforming growth factor-β2 increases extracellular matrix proteins in optic nerve head cells via activation of the Smad signaling pathway. Mol Vis. 2011; 17:1745-58. Zode GS, Sethi A, Brun-Zinkernagel AM, Chang IF, Clark AF, Wordinger RJ. PMID: 21738403; PMCID: PMC3130727.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    38. Bone morphogenetic protein 4 inhibits TGF-beta2 stimulation of extracellular matrix proteins in optic nerve head cells: role of gremlin in ECM modulation. Glia. 2009 May; 57(7):755-66. Zode GS, Clark AF, Wordinger RJ. PMID: 19031438.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    39. Focus on molecules: gremlin. Exp Eye Res. 2008 Aug; 87(2):78-9. Wordinger RJ, Zode G, Clark AF. PMID: 18201700; PMCID: PMC2649704.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    40. Activation of the BMP canonical signaling pathway in human optic nerve head tissue and isolated optic nerve head astrocytes and lamina cribrosa cells. Invest Ophthalmol Vis Sci. 2007 Nov; 48(11):5058-67. Zode GS, Clark AF, Wordinger RJ. PMID: 17962458.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    41. Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma. Invest Ophthalmol Vis Sci. 2007 Mar; 48(3):1191-200. Wordinger RJ, Fleenor DL, Hellberg PE, Pang IH, Tovar TO, Zode GS, Fuller JA, Clark AF. PMID: 17325163.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansCells
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