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Hu, Yilin

Title(s)Assistant Professor, Molecular Biology & Biochemistry
Phone(949) 824-4615
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    1. Jasniewski AJ, Wilcoxen J, Tanifuji K, Hedman B, Hodgson KO, Britt RD, Hu Y, Ribbe MW. Spectroscopic Characterization of an Eight-Iron Nitrogenase Cofactor Precursor That Lacks the "9th Sulfur". Angew Chem Int Ed Engl. 2019 Aug 14. PMID: 31411369.
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    2. Rettberg LA, Stiebritz MT, Kang W, Lee CC, Ribbe MW, Hu Y. Structural and Mechanistic Insights into CO2 Activation by Nitrogenase Iron Protein. Chemistry. 2019 Aug 11. PMID: 31402524.
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    3. Lydon BR, Lee CC, Tanifuji K, Sickerman NS, Newcomb MP, Hu Y, Ribbe MW, Yang JY. Electrochemical Characterization of Isolated Nitrogenase Cofactors from Azotobacter vinelandii. Chembiochem. 2019 Aug 07. PMID: 31392810.
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    4. Rettberg LA, Kang W, Stiebritz MT, Hiller CJ, Lee CC, Liedtke J, Ribbe MW, Hu Y. Structural Analysis of a Nitrogenase Iron Protein from Methanosarcina acetivorans: Implications for CO2 Capture by a Surface-Exposed [Fe4S4] Cluster. MBio. 2019 Jul 09; 10(4). PMID: 31289188.
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    5. Lee CC, Stiebritz MT, Hu Y. Reactivity of [Fe4S4] Clusters toward C1 Substrates: Mechanism, Implications, and Potential Applications. Acc Chem Res. 2019 May 21; 52(5):1168-1176. PMID: 30977994.
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    6. Sickerman NS, Hu Y, Ribbe MW. Nitrogenases. Methods Mol Biol. 2019; 1876:3-24. PMID: 30317471.
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    7. Jasniewski A, Hu Y, Ribbe MW. Electron Paramagnetic Resonance Spectroscopy of Metalloproteins. Methods Mol Biol. 2019; 1876:197-211. PMID: 30317483.
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    8. Stiebritz MT, Hu Y. Computational Methods for Modeling Metalloproteins. Methods Mol Biol. 2019; 1876:245-266. PMID: 30317486.
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    9. Sickerman NS, Hu Y. Hydrogenases. Methods Mol Biol. 2019; 1876:65-88. PMID: 30317475.
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    10. Lee CC, Ribbe MW, Hu Y. Purification of Nitrogenase Proteins. Methods Mol Biol. 2019; 1876:111-124. PMID: 30317477.
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    11. Hiller CJ, Lee CC, Stiebritz MT, Rettberg LA, Hu Y. Strategies Towards Capturing Nitrogenase Substrates and Intermediates via Controlled Alteration of Electron Fluxes. Chemistry. 2019 Feb 18; 25(10):2389-2395. PMID: 30225894.
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    12. Lee CC, Hu Y, Ribbe MW. Reduction and Condensation of Aldehydes by the Isolated Cofactor of Nitrogenase. ACS Cent Sci. 2018 Oct 24; 4(10):1430-1435. PMID: 30410981.
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    13. Rettberg LA, Wilcoxen J, Lee CC, Stiebritz MT, Tanifuji K, Britt RD, Hu Y. Probing the coordination and function of Fe4S4 modules in nitrogenase assembly protein NifB. Nat Commun. 2018 07 19; 9(1):2824. PMID: 30026506.
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    14. Rettberg L, Tanifuji K, Jasniewski A, Ribbe MW, Hu Y. Radical S-Adenosyl-l-Methionine (SAM) Enzyme Involved in the Maturation of the Nitrogenase Cluster. Methods Enzymol. 2018; 606:341-361. PMID: 30097098.
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    15. Tanifuji K, Lee CC, Sickerman NS, Tatsumi K, Ohki Y, Hu Y, Ribbe MW. Tracing the 'ninth sulfur' of the nitrogenase cofactor via a semi-synthetic approach. Nat Chem. 2018 05; 10(5):568-572. PMID: 29662207.
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    16. Rebelein JG, Lee CC, Newcomb M, Hu Y, Ribbe MW. Characterization of an M-Cluster-Substituted Nitrogenase VFe Protein. MBio. 2018 03 13; 9(2). PMID: 29535200.
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    17. Lee CC, Wilcoxen J, Hiller CJ, Britt RD, Hu Y. Evaluation of the Catalytic Relevance of the CO-Bound States of V-Nitrogenase. Angew Chem Int Ed Engl. 2018 03 19; 57(13):3411-3414. PMID: 29409145.
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    18. Lee CC, Tanifuji K, Newcomb M, Liedtke J, Hu Y, Ribbe MW. A Comparative Analysis of the CO-Reducing Activities of MoFe Proteins Containing Mo- and V-Nitrogenase Cofactors. Chembiochem. 2018 04 04; 19(7):649-653. PMID: 29363247.
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    19. Sickerman NS, Ribbe MW, Hu Y. Nitrogenase Cofactor Assembly: An Elemental Inventory. Acc Chem Res. 2017 11 21; 50(11):2834-2841. PMID: 29064664.
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    20. Hiller CJ, Stiebritz MT, Lee CC, Liedtke J, Hu Y. Tuning Electron Flux through Nitrogenase with Methanogen Iron Protein Homologues. Chemistry. 2017 Nov 16; 23(64):16152-16156. PMID: 28984391.
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    21. Sickerman NS, Hu Y, Ribbe MW. Nitrogenase Assembly: Strategies and Procedures. Methods Enzymol. 2017; 595:261-302. PMID: 28882203.
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    22. Sickerman NS, Tanifuji K, Hu Y, Ribbe MW. Synthetic Analogues of Nitrogenase Metallocofactors: Challenges and Developments. Chemistry. 2017 Sep 12; 23(51):12425-12432. PMID: 28726330.
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    23. Sickerman NS, Hu Y, Ribbe MW. Activation of CO2 by Vanadium Nitrogenase. Chem Asian J. 2017 Aug 17; 12(16):1985-1996. PMID: 28544649.
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    24. Sickerman NS, Rettberg LA, Lee CC, Hu Y, Ribbe MW. Cluster assembly in nitrogenase. Essays Biochem. 2017 05 09; 61(2):271-279. PMID: 28487403.
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    25. Sickerman NS, Tanifuji K, Lee CC, Ohki Y, Tatsumi K, Ribbe MW, Hu Y. Reduction of C1 Substrates to Hydrocarbons by the Homometallic Precursor and Synthetic Mimic of the Nitrogenase Cofactor. J Am Chem Soc. 2017 01 18; 139(2):603-606. PMID: 28043123.
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    26. Rebelein JG, Lee CC, Hu Y, Ribbe MW. The in vivo hydrocarbon formation by vanadium nitrogenase follows a secondary metabolic pathway. Nat Commun. 2016 12 15; 7:13641. PMID: 27976719.
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    27. Rebelein JG, Stiebritz MT, Lee CC, Hu Y. Activation and reduction of carbon dioxide by nitrogenase iron proteins. Nat Chem Biol. 2017 02; 13(2):147-149. PMID: 27893704.
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    28. Tanifuji K, Sickerman N, Lee CC, Nagasawa T, Miyazaki K, Ohki Y, Tatsumi K, Hu Y, Ribbe MW. Structure and Reactivity of an Asymmetric Synthetic Mimic of Nitrogenase Cofactor. Angew Chem Int Ed Engl. 2016 12 12; 55(50):15633-15636. PMID: 27862765.
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    29. Fay AW, Blank MA, Rebelein JG, Lee CC, Ribbe MW, Hedman B, Hodgson KO, Hu Y. Assembly scaffold NifEN: A structural and functional homolog of the nitrogenase catalytic component. Proc Natl Acad Sci U S A. 2016 08 23; 113(34):9504-8. PMID: 27506795.
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    30. Hu Y, Ribbe MW. Nitrogenases-A Tale of Carbon Atom(s). Angew Chem Int Ed Engl. 2016 07 11; 55(29):8216-26. PMID: 27206025.
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    31. Hu Y, Ribbe MW. Maturation of nitrogenase cofactor-the role of a class E radical SAM methyltransferase NifB. Curr Opin Chem Biol. 2016 04; 31:188-94. PMID: 26969410.
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    32. Lee CC, Sickerman NS, Hu Y, Ribbe MW. YedY: A Mononuclear Molybdenum Enzyme with a Redox-Active Ligand? Chembiochem. 2016 Mar 15; 17(6):453-5. PMID: 26751730.
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    33. Fay AW, Wiig JA, Lee CC, Hu Y. Identification and characterization of functional homologs of nitrogenase cofactor biosynthesis protein NifB from methanogens. Proc Natl Acad Sci U S A. 2015 Dec 01; 112(48):14829-33. PMID: 26627238.
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    34. Lee CC, Fay AW, Weng TC, Krest CM, Hedman B, Hodgson KO, Hu Y, Ribbe MW. Uncoupling binding of substrate CO from turnover by vanadium nitrogenase. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):13845-9. PMID: 26515097.
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    35. Tanifuji K, Lee CC, Ohki Y, Tatsumi K, Hu Y, Ribbe MW. Combining a Nitrogenase Scaffold and a Synthetic Compound into an Artificial Enzyme. Angew Chem Int Ed Engl. 2015 Nov 16; 54(47):14022-5. PMID: 26473503.
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    36. Wiig JA, Hu Y, Ribbe MW. Refining the pathway of carbide insertion into the nitrogenase M-cluster. Nat Commun. 2015 Aug 11; 6:8034. PMID: 26259825.
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    37. Rebelein JG, Hu Y, Ribbe MW. Widening the Product Profile of Carbon Dioxide Reduction by Vanadium Nitrogenase. Chembiochem. 2015 Sep 21; 16(14):1993-6. PMID: 26266490.
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    38. Lee CC, Hu Y, Ribbe MW. Insights into hydrocarbon formation by nitrogenase cofactor homologs. MBio. 2015 Apr 14; 6(2). PMID: 25873377.
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    39. Hu Y, Ribbe MW. Nitrogenase and homologs. J Biol Inorg Chem. 2015 Mar; 20(2):435-45. PMID: 25491285.
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    40. Lee CC, Hu Y, Ribbe MW. Catalytic reduction of CN-, CO, and CO2 by nitrogenase cofactors in lanthanide-driven reactions. Angew Chem Int Ed Engl. 2015 Jan 19; 54(4):1219-22. PMID: 25420957.
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    41. Rebelein JG, Hu Y, Ribbe MW. Differential reduction of CO2 by molybdenum and vanadium nitrogenases. Angew Chem Int Ed Engl. 2014 Oct 20; 53(43):11543-6. PMID: 25205285.
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    42. Hu Y, Ribbe MW. A journey into the active center of nitrogenase. J Biol Inorg Chem. 2014 Aug; 19(6):731-6. PMID: 24752864.
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    43. Lee CC, Ribbe MW, Hu Y. Cleaving the n,n triple bond: the transformation of dinitrogen to ammonia by nitrogenases. Met Ions Life Sci. 2014; 14:147-76. PMID: 25416394.
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    44. Ribbe MW, Hu Y, Hodgson KO, Hedman B. Biosynthesis of nitrogenase metalloclusters. Chem Rev. 2014 Apr 23; 114(8):4063-80. PMID: 24328215.
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    45. Hu Y, Ribbe MW. Biosynthesis of the iron-molybdenum cofactor of nitrogenase. J Biol Chem. 2013 May 10; 288(19):13173-7. PMID: 23539617.
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    46. Wiig JA, Lee CC, Hu Y, Ribbe MW. Tracing the interstitial carbide of the nitrogenase cofactor during substrate turnover. J Am Chem Soc. 2013 Apr 03; 135(13):4982-3. PMID: 23514429.
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    47. Hu Y, Ribbe MW. Nitrogenase assembly. Biochim Biophys Acta. 2013 Aug-Sep; 1827(8-9):1112-22. PMID: 23232096.
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    48. Wiig JA, Hu Y, Chung Lee C, Ribbe MW. Radical SAM-dependent carbon insertion into the nitrogenase M-cluster. Science. 2012 Sep 28; 337(6102):1672-5. PMID: 23019652.
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    49. Lee CC, Hu Y, Ribbe MW. ATP-independent substrate reduction by nitrogenase P-cluster variant. Proc Natl Acad Sci U S A. 2012 May 01; 109(18):6922-6. PMID: 22509042.
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    50. Lee CC, Hu Y, Ribbe MW. ATP-independent formation of hydrocarbons catalyzed by isolated nitrogenase cofactors. Angew Chem Int Ed Engl. 2012 Feb 20; 51(8):1947-9. PMID: 22253035.
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    51. Hu Y, Ribbe MW. Biosynthesis of the metalloclusters of molybdenum nitrogenase. Microbiol Mol Biol Rev. 2011 Dec; 75(4):664-77. PMID: 22126998.
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    52. Hu Y, Lee CC, Ribbe MW. Vanadium nitrogenase: a two-hit wonder? Dalton Trans. 2012 Jan 28; 41(4):1118-27. PMID: 22101422.
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    53. Hu Y, Lee CC, Ribbe MW. Extending the carbon chain: hydrocarbon formation catalyzed by vanadium/molybdenum nitrogenases. Science. 2011 Aug 05; 333(6043):753-5. PMID: 21817053.
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    54. Fay AW, Blank MA, Lee CC, Hu Y, Hodgson KO, Hedman B, Ribbe MW. Spectroscopic characterization of the isolated iron-molybdenum cofactor (FeMoco) precursor from the protein NifEN. Angew Chem Int Ed Engl. 2011 Aug 16; 50(34):7787-90. PMID: 21726031.
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    55. Wiig JA, Hu Y, Ribbe MW. NifEN-B complex of Azotobacter vinelandii is fully functional in nitrogenase FeMo cofactor assembly. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8623-7. PMID: 21551100.
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    56. Hu Y, Ribbe MW. Biosynthesis of Nitrogenase FeMoco. Coord Chem Rev. 2011 May 01; 255(9-10):1218-1224. PMID: 21503270.
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    57. Lee CC, Hu Y, Ribbe MW. Tracing the hydrogen source of hydrocarbons formed by vanadium nitrogenase. Angew Chem Int Ed Engl. 2011 Jun 06; 50(24):5545-7. PMID: 21538750.
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    58. Hu Y, Ribbe MW. Historic overview of nitrogenase research. Methods Mol Biol. 2011; 766:3-7. PMID: 21833857.
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    59. Lee CC, Fay AW, Wiig JA, Ribbe MW, Hu Y. Assembly of nitrogenase MoFe protein. Methods Mol Biol. 2011; 766:31-47. PMID: 21833859.
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    60. Wiig JA, Lee CC, Fay AW, Hu Y, Ribbe MW. Purification of nitrogenase proteins. Methods Mol Biol. 2011; 766:93-103. PMID: 21833863.
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    61. Fay AW, Lee CC, Wiig JA, Hu Y, Ribbe MW. Protocols for cofactor isolation of nitrogenase. Methods Mol Biol. 2011; 766:239-48. PMID: 21833872.
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    62. Fay AW, Blank MA, Lee CC, Hu Y, Hodgson KO, Hedman B, Ribbe MW. Characterization of isolated nitrogenase FeVco. J Am Chem Soc. 2010 Sep 15; 132(36):12612-8. PMID: 20718463.
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    63. Lee CC, Hu Y, Ribbe MW. Vanadium nitrogenase reduces CO. Science. 2010 Aug 06; 329(5992):642. PMID: 20689010.
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    64. Hu Y, Ribbe MW. Decoding the nitrogenase mechanism: the homologue approach. Acc Chem Res. 2010 Mar 16; 43(3):475-84. PMID: 20030377.
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    65. Fay AW, Blank MA, Yoshizawa JM, Lee CC, Wiig JA, Hu Y, Hodgson KO, Hedman B, Ribbe MW. Formation of a homocitrate-free iron-molybdenum cluster on NifEN: implications for the role of homocitrate in nitrogenase assembly. Dalton Trans. 2010 Mar 28; 39(12):3124-30. PMID: 20221547.
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    66. Hu Y, Fay AW, Lee CC, Wiig JA, Ribbe MW. Dual functions of NifEN: insights into the evolution and mechanism of nitrogenase. Dalton Trans. 2010 Mar 28; 39(12):2964-71. PMID: 20221527.
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    67. Yoshizawa JM, Fay AW, Lee CC, Hu Y, Ribbe MW. Insertion of heterometals into the NifEN-associated iron-molybdenum cofactor precursor. J Biol Inorg Chem. 2010 Mar; 15(3):421-8. PMID: 19967421.
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    68. Lee CC, Blank MA, Fay AW, Yoshizawa JM, Hu Y, Hodgson KO, Hedman B, Ribbe MW. Stepwise formation of P-cluster in nitrogenase MoFe protein. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18474-8. PMID: 19828444.
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    69. Hu Y, Yoshizawa JM, Fay AW, Lee CC, Wiig JA, Ribbe MW. Catalytic activities of NifEN: implications for nitrogenase evolution and mechanism. Proc Natl Acad Sci U S A. 2009 Oct 06; 106(40):16962-6. PMID: 19805110.
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    70. Yoshizawa JM, Blank MA, Fay AW, Lee CC, Wiig JA, Hu Y, Hodgson KO, Hedman B, Ribbe MW. Optimization of FeMoco maturation on NifEN. J Am Chem Soc. 2009 Jul 08; 131(26):9321-5. PMID: 19514721.
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    71. Lee CC, Hu Y, Ribbe MW. Unique features of the nitrogenase VFe protein from Azotobacter vinelandii. Proc Natl Acad Sci U S A. 2009 Jun 09; 106(23):9209-14. PMID: 19478062.
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    72. Hu Y, Fay AW, Lee CC, Yoshizawa J, Ribbe MW. Assembly of nitrogenase MoFe protein. Biochemistry. 2008 Apr 01; 47(13):3973-81. PMID: 18314963.
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    73. Hu Y, Fay AW, Lee CC, Ribbe MW. P-cluster maturation on nitrogenase MoFe protein. Proc Natl Acad Sci U S A. 2007 Jun 19; 104(25):10424-9. PMID: 17563349.
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    74. Fay AW, Hu Y, Schmid B, Ribbe MW. Molecular insights into nitrogenase FeMoco insertion--the role of His 274 and His 451 of MoFe protein alpha subunit. J Inorg Biochem. 2007 Nov; 101(11-12):1630-41. PMID: 17521738.
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    75. Hu Y, Fay AW, Ribbe MW. Molecular insights into nitrogenase FeMo cofactor insertion: the role of His 362 of the MoFe protein alpha subunit in FeMo cofactor incorporation. J Biol Inorg Chem. 2007 May; 12(4):449-60. PMID: 17203313.
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    76. Hu Y, Corbett MC, Fay AW, Webber JA, Hodgson KO, Hedman B, Ribbe MW. Nitrogenase Fe protein: A molybdate/homocitrate insertase. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17125-30. PMID: 17062756.
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    77. Hu Y, Corbett MC, Fay AW, Webber JA, Hodgson KO, Hedman B, Ribbe MW. FeMo cofactor maturation on NifEN. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17119-24. PMID: 17050696.
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    78. Hu Y, Fay AW, Schmid B, Makar B, Ribbe MW. Molecular insights into nitrogenase FeMoco insertion: TRP-444 of MoFe protein alpha-subunit locks FeMoco in its binding site. J Biol Chem. 2006 Oct 13; 281(41):30534-41. PMID: 16893897.
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    79. Hu Y, Corbett MC, Fay AW, Webber JA, Hedman B, Hodgson KO, Ribbe MW. Nitrogenase reactivity with P-cluster variants. Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39):13825-30. PMID: 16166259.
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    80. Hu Y, Fay AW, Ribbe MW. Identification of a nitrogenase FeMo cofactor precursor on NifEN complex. Proc Natl Acad Sci U S A. 2005 Mar 01; 102(9):3236-41. PMID: 15728375.
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    81. Hu Y, Fay AW, Dos Santos PC, Naderi F, Ribbe MW. Characterization of Azotobacter vinelandii nifZ deletion strains. Indication of stepwise MoFe protein assembly. J Biol Chem. 2004 Dec 24; 279(52):54963-71. PMID: 15485884.
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    82. Ribbe MW, Hu Y, Guo M, Schmid B, Burgess BK. The FeMoco-deficient MoFe protein produced by a nifH deletion strain of Azotobacter vinelandii shows unusual P-cluster features. J Biol Chem. 2002 Jun 28; 277(26):23469-76. PMID: 11978793.
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