David Jordan Adams

Title(s)Assistant Health Sciences Professor, Pediatrics
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(714) 509-3605
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    1. Tabernanthalog and ibogainalog inhibit the α7 and α9α10 nicotinic acetylcholine receptors via different mechanisms and with higher potency than the GABAA receptor and CaV2.2 channel. Biochem Pharmacol. 2024 05; 223:116183. Tae HS, Ortells MO, Yousuf A, Xu SQ, Akk G, Adams DJ, Arias HR. PMID: 38580167; PMCID: PMC11151864.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. Rational Design of Potent α-Conotoxin PeIA Analogues with Non-Natural Amino Acids for the Inhibition of Human α9α10 Nicotinic Acetylcholine Receptors. Mar Drugs. 2024 Feb 27; 22(3). Li T, Tae HS, Liang J, Zhang Z, Li X, Jiang T, Adams DJ, Yu R. PMID: 38535451; PMCID: PMC10971807.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Dual Antagonism of α9α10 nAChR and GABAB Receptor-Coupled CaV2.2 Channels by an Analgesic αO-Conotoxin Analogue. J Med Chem. 2024 Jan 25; 67(2):971-987. Li X, Tae HS, Chen S, Yousuf A, Huang L, Zhang J, Jiang T, Adams DJ, Yu R. PMID: 38217860.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    4. Interrater reliability of interictal EEG waveforms in Lennox-Gastaut Syndrome. Epilepsia Open. 2024 Feb; 9(1):176-186. Hu DK, Rana M, Adams DJ, Do L, Shrey DW, Hussain SA, Lopour BA. PMID: 37920928; PMCID: PMC10839292.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. A previously unrecognized superfamily of macro-conotoxins includes an inhibitor of the sensory neuron calcium channel Cav2.3. PLoS Biol. 2023 08; 21(8):e3002217. Hackney CM, Flórez Salcedo P, Mueller E, Koch TL, Kjelgaard LD, Watkins M, Zachariassen LG, Tuelung PS, McArthur JR, Adams DJ, Kristensen AS, Olivera B, Finol-Urdaneta RK, Safavi-Hemami H, Morth JP, Ellgaard L. PMID: 37535677; PMCID: PMC10437998.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    6. DM506 (3-Methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole fumarate), a Novel Derivative of Ibogamine, Inhibits α7 and α9α10 Nicotinic Acetylcholine Receptors by Different Allosteric Mechanisms. ACS Chem Neurosci. 2023 07 19; 14(14):2537-2547. Tae HS, Ortells MO, Tekarli BJ, Manetti D, Romanelli MN, McIntosh JM, Adams DJ, Arias HR. PMID: 37386821.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    7. Automated Patch Clamp Screening of Amiloride and 5-N,N-Hexamethyleneamiloride Analogs Identifies 6-Iodoamiloride as a Potent Acid-Sensing Ion Channel Inhibitor. Mol Pharm. 2023 07 03; 20(7):3367-3379. Finol-Urdaneta RK, McArthur JR, Aboelela A, Bujaroski RS, Majed H, Rangel A, Adams DJ, Ranson M, Kelso MJ, Buckley BJ. PMID: 37260417.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    8. The Antinociceptive Activity of (E)-3-(thiophen-2-yl)- N -(p-tolyl)acrylamide in Mice Is Reduced by (E)-3-(furan-2-yl)- N -methyl- N -(p-tolyl)acrylamide Through Opposing Modulatory Mechanisms at the α7 Nicotinic Acetylcholine Receptor. Anesth Analg. 2023 09 01; 137(3):691-701. Arias HR, Tae HS, Micheli L, Yousuf A, Manetti D, Romanelli MN, Ghelardini C, Adams DJ, Di Cesare Mannelli L. PMID: 37058425; PMCID: PMC10408732.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    9. Nicotinic acetylcholine receptor subtype expression, function, and pharmacology: Therapeutic potential of α-conotoxins. Pharmacol Res. 2023 05; 191:106747. Tae HS, Adams DJ. PMID: 37001708.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    10. Nicotinic acetylcholine receptors: Key targets for attenuating neurodegenerative diseases. Int J Biochem Cell Biol. 2023 04; 157:106387. Bye LJ, Finol-Urdaneta RK, Tae HS, Adams DJ. PMID: 36754161.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    11. Characterisation of Elevenin-Vc1 from the Venom of Conus victoriae: A Structural Analogue of α-Conotoxins. Mar Drugs. 2023 Jan 25; 21(2). Krishnarjuna B, Sunanda P, Seow J, Tae HS, Robinson SD, Belgi A, Robinson AJ, Safavi-Hemami H, Adams DJ, Norton RS. PMID: 36827123; PMCID: PMC9963005.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    12. Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis. Cancer Res. 2022 11 15; 82(22):4261-4273. Vaishnavi A, Juan J, Jacob M, Stehn C, Gardner EE, Scherzer MT, Schuman S, Van Veen JE, Murphy B, Hackett CS, Dupuy AJ, Chmura SA, van der Weyden L, Newberg JY, Liu A, Mann K, Rust AG, Weiss WA, Kinsey CG, Adams DJ, Grossmann A, Mann MB, McMahon M. PMID: 36112789; PMCID: PMC9664136.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    13. Mechanism of Action and Structure-Activity Relationship of α-Conotoxin Mr1.1 at the Human α9α10 Nicotinic Acetylcholine Receptor. J Med Chem. 2022 12 22; 65(24):16204-16217. Liang J, Tae HS, Zhao Z, Li X, Zhang J, Chen S, Jiang T, Adams DJ, Yu R. PMID: 36137181.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    14. Analgesic α-Conotoxin Binding Site on the Human GABAB Receptor. Mol Pharmacol. 2022 10; 102(4):196-208. Bony AR, McArthur JR, Komori A, Wong AR, Hung A, Adams DJ. PMID: 35944919.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    15. Single-Disulfide Conopeptide Czon1107, an Allosteric Antagonist of the Human α3β4 Nicotinic Acetylcholine Receptor. Mar Drugs. 2022 Jul 31; 20(8). Ma Y, Cao Q, Yang M, Gao Y, Fu S, Du W, Adams DJ, Jiang T, Tae HS, Yu R. PMID: 36005500; PMCID: PMC9409646.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Investigation of CACNA1I Cav3.3 Dysfunction in Hemiplegic Migraine. Front Mol Neurosci. 2022; 15:892820. Maksemous N, Blayney CD, Sutherland HG, Smith RA, Lea RA, Tran KN, Ibrahim O, McArthur JR, Haupt LM, Cader MZ, Finol-Urdaneta RK, Adams DJ, Griffiths LR. PMID: 35928792; PMCID: PMC9345121.
      View in: PubMed   Mentions: 5  
    17. Glycinergic Modulation of Pain in Behavioral Animal Models. Front Pharmacol. 2022; 13:860903. Peiser-Oliver JM, Evans S, Adams DJ, Christie MJ, Vandenberg RJ, Mohammadi SA. PMID: 35694265; PMCID: PMC9174897.
      View in: PubMed   Mentions: 3  
    18. Cysteine-Rich α-Conotoxin SII Displays Novel Interactions at the Muscle Nicotinic Acetylcholine Receptor. ACS Chem Neurosci. 2022 04 20; 13(8):1245-1250. Wilhelm P, Luna-Ramirez K, Chin YK, Dekan Z, Abraham N, Tae HS, Chow CY, Eagles DA, King GF, Lewis RJ, Adams DJ, Alewood PF. PMID: 35357806.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    19. Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider. Proc Natl Acad Sci U S A. 2022 02 01; 119(5). Finol-Urdaneta RK, Ziegman R, Dekan Z, McArthur JR, Heitmann S, Luna-Ramirez K, Tae HS, Mueller A, Starobova H, Chin YK, Wingerd JS, Undheim EAB, Cristofori-Armstrong B, Hill AP, Herzig V, King GF, Vetter I, Rash LD, Adams DJ, Alewood PF. PMID: 35074873; PMCID: PMC8812547.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    20. Analgesic α-conotoxins modulate native and recombinant GIRK1/2 channels via activation of GABAB receptors and reduce neuroexcitability. Br J Pharmacol. 2022 01; 179(1):179-198. Bony AR, McArthur JR, Finol-Urdaneta RK, Adams DJ. PMID: 34599513.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    21. ɑO-Conotoxin GeXIVA isomers modulate N-type calcium (CaV 2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABAB receptor activation. J Neurochem. 2022 01; 160(2):154-171. Yousuf A, Wu X, Bony AR, Sadeghi M, Huang YH, Craik DJ, Adams DJ. PMID: 34738241.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    22. Electrical properties and synaptic transmission in mouse intracardiac ganglion neurons in situ. Physiol Rep. 2021 09; 9(18):e15056. Harper AA, Adams DJ. PMID: 34582125; PMCID: PMC8477906.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    23. α-Conotoxin Bt1.8 from Conus betulinus selectively inhibits α6/α3β2β3 and α3β2 nicotinic acetylcholine receptor subtypes. J Neurochem. 2021 10; 159(1):90-100. Ning H, Huang B, Tae HS, Liu Z, Yu S, Li L, Zhang L, Adams DJ, Guo C, Dai Q. PMID: 34008858.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    24. Globular and ribbon isomers of Conus geographus α-conotoxins antagonize human nicotinic acetylcholine receptors. Biochem Pharmacol. 2021 08; 190:114638. Tae HS, Gao B, Jin AH, Alewood PF, Adams DJ. PMID: 34062129.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    25. Alkyne-Bridged α-Conotoxin Vc1.1 Potently Reverses Mechanical Allodynia in Neuropathic Pain Models. J Med Chem. 2021 03 25; 64(6):3222-3233. Belgi A, Burnley JV, MacRaild CA, Chhabra S, Elnahriry KA, Robinson SD, Gooding SG, Tae HS, Bartels P, Sadeghi M, Zhao FY, Wei H, Spanswick D, Adams DJ, Norton RS, Robinson AJ. PMID: 33724033.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    26. Trends in peptide drug discovery. Nat Rev Drug Discov. 2021 04; 20(4):309-325. Muttenthaler M, King GF, Adams DJ, Alewood PF. PMID: 33536635.
      View in: PubMed   Mentions: 363     Fields:    Translation:HumansAnimalsCells
    27. Spider Venom Peptide Pn3a Inhibition of Primary Afferent High Voltage-Activated Calcium Channels. Front Pharmacol. 2020; 11:633679. McArthur JR, Munasinghe NR, Finol-Urdaneta RK, Adams DJ, Christie MJ. PMID: 33584315; PMCID: PMC7875911.
      View in: PubMed   Mentions: 3  
    28. Venom-Derived Peptides Inhibiting Voltage-Gated Sodium and Calcium Channels in Mammalian Sensory Neurons. Adv Exp Med Biol. 2021; 1349:3-19. Yousuf A, Sadeghi M, Adams DJ. PMID: 35138607.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    29. Medicinal chemistry, pharmacology, and therapeutic potential of α-conotoxins antagonizing the α9α10 nicotinic acetylcholine receptor. Pharmacol Ther. 2021 06; 222:107792. Li X, Tae HS, Chu Y, Jiang T, Adams DJ, Yu R. PMID: 33309557.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    30. (E)-3-Furan-2-yl-N-p-tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor Potentiation. ACS Chem Neurosci. 2020 11 04; 11(21):3603-3614. Arias HR, Ghelardini C, Lucarini E, Tae HS, Yousuf A, Marcovich I, Manetti D, Romanelli MN, Elgoyhen AB, Adams DJ, Di Cesare Mannelli L. PMID: 33073974.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    31. Rational Design of α-Conotoxin RegIIA Analogues Selectively Inhibiting the Human α3β2 Nicotinic Acetylcholine Receptor through Computational Scanning. ACS Chem Neurosci. 2020 09 16; 11(18):2804-2811. Xu Q, Tae HS, Wang Z, Jiang T, Adams DJ, Yu R. PMID: 32649832.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    32. Interactions of the α3β2 Nicotinic Acetylcholine Receptor Interfaces with α-Conotoxin LsIA and its Carboxylated C-terminus Analogue: Molecular Dynamics Simulations. Mar Drugs. 2020 Jul 03; 18(7). Wen J, Adams DJ, Hung A. PMID: 32635340; PMCID: PMC7401271.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    33. Coronaridine congeners decrease neuropathic pain in mice and inhibit α9α10 nicotinic acetylcholine receptors and CaV2.2 channels. Neuropharmacology. 2020 09 15; 175:108194. Arias HR, Tae HS, Micheli L, Yousuf A, Ghelardini C, Adams DJ, Di Cesare Mannelli L. PMID: 32540451.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    34. Dimerization of α-Conotoxins as a Strategy to Enhance the Inhibition of the Human α7 and α9α10 Nicotinic Acetylcholine Receptors. J Med Chem. 2020 03 26; 63(6):2974-2985. Liang J, Tae HS, Xu X, Jiang T, Adams DJ, Yu R. PMID: 32101438.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    35. Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors. Br J Pharmacol. 2020 04; 177(8):1822-1840. Foo CS, Jobichen C, Hassan-Puttaswamy V, Dekan Z, Tae HS, Bertrand D, Adams DJ, Alewood PF, Sivaraman J, Nirthanan S, Kini RM. PMID: 31877243; PMCID: PMC7070178.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    36. Ketamine inhibits synaptic transmission and nicotinic acetylcholine receptor-mediated responses in rat intracardiac ganglia in situ. Neuropharmacology. 2020 03 15; 165:107932. Harper AA, Rimmer K, Dyavanapalli J, McArthur JR, Adams DJ. PMID: 31911104.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    37. Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom. Biochem Pharmacol. 2020 04; 174:113782. Luna-Ramirez K, Csoti A, McArthur JR, Chin YKY, Anangi R, Najera RDC, Possani LD, King GF, Panyi G, Yu H, Adams DJ, Finol-Urdaneta RK. PMID: 31881193.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    38. On-resin strategy to label α-conotoxins: Cy5-RgIA, a potent α9α10 nicotinic acetylcholine receptor imaging probe. Aust J Chem. 2020; 73(4):327-333. Muttenthaler M, Nevin ST, Inserra M, Lewis RJ, Adams DJ, Alewood P. PMID: 32394983; PMCID: PMC7212043.
      View in: PubMed   Mentions: 4  
    39. α-Conotoxin Vc1.1 Structure-Activity Relationship at the Human α9α10 Nicotinic Acetylcholine Receptor Investigated by Minimal Side Chain Replacement. ACS Chem Neurosci. 2019 10 16; 10(10):4328-4336. Chu X, Tae HS, Xu Q, Jiang T, Adams DJ, Yu R. PMID: 31411453.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    40. Molecular dynamics simulations of dihydro-β-erythroidine bound to the human α4β2 nicotinic acetylcholine receptor. Br J Pharmacol. 2019 08; 176(15):2750-2763. Yu R, Tae HS, Xu Q, Craik DJ, Adams DJ, Jiang T, Kaas Q. PMID: 31062355; PMCID: PMC6609542.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    41. Analgesic transient receptor potential vanilloid-1-active compounds inhibit native and recombinant T-type calcium channels. Br J Pharmacol. 2019 07; 176(13):2264-2278. McArthur JR, Finol-Urdaneta RK, Adams DJ. PMID: 30927254; PMCID: PMC6555866.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    42. Drysdalin, an antagonist of nicotinic acetylcholine receptors highlights the importance of functional rather than structural conservation of amino acid residues. FASEB Bioadv. 2019 Feb; 1(2):115-131. Chandna R, Tae HS, Seymour VAL, Chathrath S, Adams DJ, Kini RM. PMID: 32123825; PMCID: PMC6996315.
      View in: PubMed   Mentions: 6  
    43. Targeting of N-Type Calcium Channels via GABAB-Receptor Activation by α-Conotoxin Vc1.1 Variants Displaying Improved Analgesic Activity. J Med Chem. 2018 11 21; 61(22):10198-10205. Cai F, Xu N, Liu Z, Ding R, Yu S, Dong M, Wang S, Shen J, Tae HS, Adams DJ, Zhang X, Dai Q. PMID: 30358401.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    44. NMR Structure of μ-Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced NaV Channel Potency. Molecules. 2018 Oct 22; 23(10). Harvey PJ, Kurniawan ND, Finol-Urdaneta RK, McArthur JR, Van Lysebetten D, Dash TS, Hill JM, Adams DJ, Durek T, Craik DJ. PMID: 30360356; PMCID: PMC6222493.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    45. A lentiviral vector-based insertional mutagenesis screen identifies mechanisms of resistance to MAPK inhibitors in melanoma. Pigment Cell Melanoma Res. 2019 03; 32(2):332-335. Ranzani M, Alifrangis C, Thompson NA, Rust AG, Allahyar A, Iyer V, Price S, Ellis P, Turner G, de Ridder J, McDermott U, Adams DJ. PMID: 30218636.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    46. Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides. Sci Rep. 2018 09 07; 8(1):13397. Sousa SR, McArthur JR, Brust A, Bhola RF, Rosengren KJ, Ragnarsson L, Dutertre S, Alewood PF, Christie MJ, Adams DJ, Vetter I, Lewis RJ. PMID: 30194442; PMCID: PMC6128854.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    47. Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB. Biochem Pharmacol. 2018 09; 155:288-297. Wu X, Tae HS, Huang YH, Adams DJ, Craik DJ, Kaas Q. PMID: 30009767.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    48. Structure-Activity Studies Reveal the Molecular Basis for GABAB-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1. ACS Chem Biol. 2018 06 15; 13(6):1577-1587. Sadeghi M, Carstens BB, Callaghan BP, Daniel JT, Tae HS, O'Donnell T, Castro J, Brierley SM, Adams DJ, Craik DJ, Clark RJ. PMID: 29746088.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    49. Molecular Determinants Conferring the Stoichiometric-Dependent Activity of α-Conotoxins at the Human α9α10 Nicotinic Acetylcholine Receptor Subtype. J Med Chem. 2018 05 24; 61(10):4628-4634. Yu R, Tae HS, Tabassum N, Shi J, Jiang T, Adams DJ. PMID: 29733583.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    50. Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain. Br J Pharmacol. 2018 06; 175(12):2384-2398. Castro J, Grundy L, Deiteren A, Harrington AM, O'Donnell T, Maddern J, Moore J, Garcia-Caraballo S, Rychkov GY, Yu R, Kaas Q, Craik DJ, Adams DJ, Brierley SM. PMID: 29194563; PMCID: PMC5980271.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    51. A novel α-conopeptide Eu1.6 inhibits N-type (CaV2.2) calcium channels and exhibits potent analgesic activity. Sci Rep. 2018 01 17; 8(1):1004. Liu Z, Bartels P, Sadeghi M, Du T, Dai Q, Zhu C, Yu S, Wang S, Dong M, Sun T, Guo J, Peng S, Jiang L, Adams DJ, Dai Q. PMID: 29343689; PMCID: PMC5772529.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    52. Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors. Sci Rep. 2017 11 30; 7(1):16606. Durek T, Shelukhina IV, Tae HS, Thongyoo P, Spirova EN, Kudryavtsev DS, Kasheverov IE, Faure G, Corringer PJ, Craik DJ, Adams DJ, Tsetlin VI. PMID: 29192197; PMCID: PMC5709491.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    53. Neuropharmacology of venom peptides. Neuropharmacology. 2017 12; 127:1-3. Adams DJ, Lewis RJ. PMID: 29154773.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    54. In vivo and in vitro testing of native α-conotoxins from the injected venom of Conus purpurascens. Neuropharmacology. 2017 Dec; 127:253-259. Hoggard MF, Rodriguez AM, Cano H, Clark E, Tae HS, Adams DJ, Godenschwege TA, Marí F. PMID: 28917942.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    55. Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer. J Biol Chem. 2017 10 13; 292(41):17101-17112. Wu X, Huang YH, Kaas Q, Harvey PJ, Wang CK, Tae HS, Adams DJ, Craik DJ. PMID: 28851841; PMCID: PMC5641895.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    56. Role of CysI-CysIII Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors. ACS Omega. 2017 Aug 31; 2(8):4621-4631. Tabassum N, Tae HS, Jia X, Kaas Q, Jiang T, Adams DJ, Yu R. PMID: 30023726; PMCID: PMC6044955.
      View in: PubMed   Mentions: 6  
    57. Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1. Br J Pharmacol. 2018 06; 175(12):2284-2295. McArthur JR, Motin L, Gleeson EC, Spiller S, Lewis RJ, Duggan PJ, Tuck KL, Adams DJ. PMID: 28608537; PMCID: PMC5980596.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    58. Identifying transposon insertions and their effects from RNA-sequencing data. Nucleic Acids Res. 2017 Jul 07; 45(12):7064-7077. de Ruiter JR, Kas SM, Schut E, Adams DJ, Koudijs MJ, Wessels LFA, Jonkers J. PMID: 28575524; PMCID: PMC5499543.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    59. Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma. Nat Genet. 2017 Aug; 49(8):1219-1230. Kas SM, de Ruiter JR, Schipper K, Annunziato S, Schut E, Klarenbeek S, Drenth AP, van der Burg E, Klijn C, Ten Hoeve JJ, Adams DJ, Koudijs MJ, Wesseling J, Nethe M, Wessels LFA, Jonkers J. PMID: 28650484.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    60. α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition. Br J Pharmacol. 2018 06; 175(11):1855-1868. Cuny H, Yu R, Tae HS, Kompella SN, Adams DJ. PMID: 28477355; PMCID: PMC5979624.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    61. Identification of a Novel O-Conotoxin Reveals an Unusual and Potent Inhibitor of the Human α9α10 Nicotinic Acetylcholine Receptor. Mar Drugs. 2017 Jun 09; 15(6). Jiang S, Tae HS, Xu S, Shao X, Adams DJ, Wang C. PMID: 28598389; PMCID: PMC5484120.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    62. A Novel Lid-Covering Peptide Inhibitor of Nicotinic Acetylcholine Receptors Derived from αD-Conotoxin GeXXA. Mar Drugs. 2017 Jun 05; 15(6). Yang L, Tae HS, Fan Z, Shao X, Xu S, Zhao S, Adams DJ, Wang C. PMID: 28587231; PMCID: PMC5484114.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    63. Analgesic conopeptides targeting G protein-coupled receptors reduce excitability of sensory neurons. Neuropharmacology. 2017 Dec; 127:116-123. Sadeghi M, McArthur JR, Finol-Urdaneta RK, Adams DJ. PMID: 28533165.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    64. The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity. Sci Rep. 2017 04 20; 7(1):974. Wingerd JS, Mozar CA, Ussing CA, Murali SS, Chin YK, Cristofori-Armstrong B, Durek T, Gilchrist J, Vaughan CW, Bosmans F, Adams DJ, Lewis RJ, Alewood PF, Mobli M, Christie MJ, Rash LD. PMID: 28428547; PMCID: PMC5430537.
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    65. Transposon insertional mutagenesis in mice identifies human breast cancer susceptibility genes and signatures for stratification. Proc Natl Acad Sci U S A. 2017 03 14; 114(11):E2215-E2224. Chen L, Jenjaroenpun P, Pillai AM, Ivshina AV, Ow GS, Efthimios M, Zhiqun T, Tan TZ, Lee SC, Rogers K, Ward JM, Mori S, Adams DJ, Jenkins NA, Copeland NG, Ban KH, Kuznetsov VA, Thiery JP. PMID: 28251929; PMCID: PMC5358385.
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    66. Effects of linker sequence modifications on the structure, stability, and biological activity of a cyclic α-conotoxin. Biopolymers. 2016 Nov; 106(6):864-875. Carstens BB, Swedberg J, Berecki G, Adams DJ, Craik DJ, Clark RJ. PMID: 27038328.
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    67. Key Structural Determinants in the Agonist Binding Loops of Human β2 and β4 Nicotinic Acetylcholine Receptor Subunits Contribute to α3β4 Subtype Selectivity of α-Conotoxins. J Biol Chem. 2016 Nov 04; 291(45):23779-23792. Cuny H, Kompella SN, Tae HS, Yu R, Adams DJ. PMID: 27646000; PMCID: PMC5095430.
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    68. A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice. G3 (Bethesda). 2016 08 09; 6(8):2343-54. McIntyre RE, Nicod J, Robles-Espinoza CD, Maciejowski J, Cai N, Hill J, Verstraten R, Iyer V, Rust AG, Balmus G, Mott R, Flint J, Adams DJ. PMID: 27233670; PMCID: PMC4978889.
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    69. Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer. Proc Natl Acad Sci U S A. 2016 07 19; 113(29):8290-5. Ahmad I, Mui E, Galbraith L, Patel R, Tan EH, Salji M, Rust AG, Repiscak P, Hedley A, Markert E, Loveridge C, van der Weyden L, Edwards J, Sansom OJ, Adams DJ, Leung HY. PMID: 27357679; PMCID: PMC4961202.
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    70. Mechanism of direct Cav2.2 channel block by the κ-opioid receptor agonist U50488H. Neuropharmacology. 2016 10; 109:49-58. Berecki G, Motin L, Adams DJ. PMID: 27245500.
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    71. Structure-Activity Studies of Cysteine-Rich α-Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABA(B) Receptor Activation Reveal a Minimal Functional Motif. Angew Chem Int Ed Engl. 2016 Apr 04; 55(15):4692-6. Carstens BB, Berecki G, Daniel JT, Lee HS, Jackson KA, Tae HS, Sadeghi M, Castro J, O'Donnell T, Deiteren A, Brierley SM, Craik DJ, Adams DJ, Clark RJ. PMID: 26948522.
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    72. α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptors. Gut. 2017 06; 66(6):1083-1094. Castro J, Harrington AM, Garcia-Caraballo S, Maddern J, Grundy L, Zhang J, Page G, Miller PE, Craik DJ, Adams DJ, Brierley SM. PMID: 26887818; PMCID: PMC5532460.
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    73. Modulation of human Nav1.7 channel gating by synthetic α-scorpion toxin OD1 and its analogs. Channels (Austin). 2016; 10(2):139-47. Motin L, Durek T, Adams DJ. PMID: 26646206; PMCID: PMC4960991.
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    74. Adenoma development in familial adenomatous polyposis and MUTYH-associated polyposis: somatic landscape and driver genes. J Pathol. 2016 Jan; 238(1):98-108. Rashid M, Fischer A, Wilson CH, Tiffen J, Rust AG, Stevens P, Idziaszczyk S, Maynard J, Williams GT, Mustonen V, Sampson JR, Adams DJ. PMID: 26414517; PMCID: PMC4832337.
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    75. Transforming conotoxins into cyclotides: Backbone cyclization of P-superfamily conotoxins. Biopolymers. 2015 Nov; 104(6):682-92. Akcan M, Clark RJ, Daly NL, Conibear AC, de Faoite A, Heghinian MD, Sahil T, Adams DJ, Marí F, Craik DJ. PMID: 26172377.
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    76. Voltage-Gated R-Type Calcium Channel Inhibition via Human μ-, δ-, and κ-opioid Receptors Is Voltage-Independently Mediated by Gβγ Protein Subunits. Mol Pharmacol. 2016 Jan; 89(1):187-96. Berecki G, Motin L, Adams DJ. PMID: 26490245.
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    77. The utility of transposon mutagenesis for cancer studies in the era of genome editing. Genome Biol. 2015 Oct 19; 16:229. DeNicola GM, Karreth FA, Adams DJ, Wong CC. PMID: 26481584; PMCID: PMC4612416.
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    78. A Distinct Functional Site in Ω-Neurotoxins: Novel Antagonists of Nicotinic Acetylcholine Receptors from Snake Venom. ACS Chem Biol. 2015 Dec 18; 10(12):2805-15. Hassan-Puttaswamy V, Adams DJ, Kini RM. PMID: 26448325.
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    79. Molecular Basis for Differential Sensitivity of α-Conotoxin RegIIA at Rat and Human Neuronal Nicotinic Acetylcholine Receptors. Mol Pharmacol. 2015 Dec; 88(6):993-1001. Kompella SN, Cuny H, Hung A, Adams DJ. PMID: 26438212.
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    80. Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors. Sci Rep. 2015 Sep 23; 5:14261. Xu S, Zhang T, Kompella SN, Yan M, Lu A, Wang Y, Shao X, Chi C, Adams DJ, Ding J, Wang C. PMID: 26395518; PMCID: PMC4585798.
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    81. A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression. J Exp Med. 2015 Sep 21; 212(10):1551-69. Giotopoulos G, van der Weyden L, Osaki H, Rust AG, Gallipoli P, Meduri E, Horton SJ, Chan WI, Foster D, Prinjha RK, Pimanda JE, Tenen DG, Vassiliou GS, Koschmieder S, Adams DJ, Huntly BJ. PMID: 26304963; PMCID: PMC4577832.
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    82. Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1. Sci Rep. 2015 Aug 20; 5:13264. Yu R, Seymour VA, Berecki G, Jia X, Akcan M, Adams DJ, Kaas Q, Craik DJ. PMID: 26290113; PMCID: PMC4542547.
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    83. Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5(+/-) leukemia. BMC Cancer. 2015 Aug 13; 15:585. van der Weyden L, Giotopoulos G, Wong K, Rust AG, Robles-Espinoza CD, Osaki H, Huntly BJ, Adams DJ. PMID: 26269126; PMCID: PMC4542115.
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    84. PAX5 is a tumor suppressor in mouse mutagenesis models of acute lymphoblastic leukemia. Blood. 2015 Jun 04; 125(23):3609-17. Dang J, Wei L, de Ridder J, Su X, Rust AG, Roberts KG, Payne-Turner D, Cheng J, Ma J, Qu C, Wu G, Song G, Huether RG, Schulman B, Janke L, Zhang J, Downing JR, van der Weyden L, Adams DJ, Mullighan CG. PMID: 25855603; PMCID: PMC4458800.
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    85. α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors. J Am Chem Soc. 2015 Mar 11; 137(9):3209-12. Wan J, Huang JX, Vetter I, Mobli M, Lawson J, Tae HS, Abraham N, Paul B, Cooper MA, Adams DJ, Lewis RJ, Alewood PF. PMID: 25710197.
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    86. BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model. Proc Natl Acad Sci U S A. 2015 Feb 10; 112(6):E536-45. Perna D, Karreth FA, Rust AG, Perez-Mancera PA, Rashid M, Iorio F, Alifrangis C, Arends MJ, Bosenberg MW, Bollag G, Tuveson DA, Adams DJ. PMID: 25624498; PMCID: PMC4330752.
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    87. Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression. Nat Genet. 2015 Feb; 47(2):142-50. Takeda H, Wei Z, Koso H, Rust AG, Yew CC, Mann MB, Ward JM, Adams DJ, Copeland NG, Jenkins NA. PMID: 25559195.
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    88. Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma. J Natl Cancer Inst. 2015 Feb; 107(2). Aoude LG, Pritchard AL, Robles-Espinoza CD, Wadt K, Harland M, Choi J, Gartside M, Quesada V, Johansson P, Palmer JM, Ramsay AJ, Zhang X, Jones K, Symmons J, Holland EA, Schmid H, Bonazzi V, Woods S, Dutton-Regester K, Stark MS, Snowden H, van Doorn R, Montgomery GW, Martin NG, Keane TM, López-Otín C, Gerdes AM, Olsson H, Ingvar C, Borg A, Gruis NA, Trent JM, Jönsson G, Bishop DT, Mann GJ, Newton-Bishop JA, Brown KM, Adams DJ, Hayward NK. PMID: 25505254; PMCID: PMC4334787.
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    89. Inhibition of cholinergic pathways in Drosophila melanogaster by α-conotoxins. FASEB J. 2015 Mar; 29(3):1011-8. Heghinian MD, Mejia M, Adams DJ, Godenschwege TA, Marí F. PMID: 25466886; PMCID: PMC4422358.
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    90. Dicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targets. J Med Chem. 2014 Dec 11; 57(23):9933-44. Chhabra S, Belgi A, Bartels P, van Lierop BJ, Robinson SD, Kompella SN, Hung A, Callaghan BP, Adams DJ, Robinson AJ, Norton RS. PMID: 25393758.
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    91. Novel mechanism of voltage-gated N-type (Cav2.2) calcium channel inhibition revealed through α-conotoxin Vc1.1 activation of the GABA(B) receptor. Mol Pharmacol. 2015 Feb; 87(2):240-50. Huynh TG, Cuny H, Slesinger PA, Adams DJ. PMID: 25425625.
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    92. Alanine scan of α-conotoxin RegIIA reveals a selective α3β4 nicotinic acetylcholine receptor antagonist. J Biol Chem. 2015 Jan 09; 290(2):1039-48. Kompella SN, Hung A, Clark RJ, Marí F, Adams DJ. PMID: 25411242; PMCID: PMC4294472.
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    93. The mutational landscapes of genetic and chemical models of Kras-driven lung cancer. Nature. 2015 Jan 22; 517(7535):489-92. Westcott PM, Halliwill KD, To MD, Rashid M, Rust AG, Keane TM, Delrosario R, Jen KY, Gurley KE, Kemp CJ, Fredlund E, Quigley DA, Adams DJ, Balmain A. PMID: 25363767; PMCID: PMC4304785.
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    94. Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptors. Biochem Pharmacol. 2014 Oct 15; 91(4):534-42. Hopping G, Wang CI, Hogg RC, Nevin ST, Lewis RJ, Adams DJ, Alewood PF. PMID: 25101833.
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    95. Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation. J Gen Physiol. 2014 Apr; 143(4):465-79. Berecki G, McArthur JR, Cuny H, Clark RJ, Adams DJ. PMID: 24688019; PMCID: PMC3971658.
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    96. POT1 loss-of-function variants predispose to familial melanoma. Nat Genet. 2014 May; 46(5):478-481. Robles-Espinoza CD, Harland M, Ramsay AJ, Aoude LG, Quesada V, Ding Z, Pooley KA, Pritchard AL, Tiffen JC, Petljak M, Palmer JM, Symmons J, Johansson P, Stark MS, Gartside MG, Snowden H, Montgomery GW, Martin NG, Liu JZ, Choi J, Makowski M, Brown KM, Dunning AM, Keane TM, López-Otín C, Gruis NA, Hayward NK, Bishop DT, Newton-Bishop JA, Adams DJ. PMID: 24686849; PMCID: PMC4266105.
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    97. Identification of FoxR2 as an oncogene in medulloblastoma. Cancer Res. 2014 Apr 15; 74(8):2351-61. Koso H, Tsuhako A, Lyons E, Ward JM, Rust AG, Adams DJ, Jenkins NA, Copeland NG, Watanabe S. PMID: 24599127.
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    98. Insertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottleneck in lymphomagenesis. PLoS Genet. 2014 Feb; 10(2):e1004167. Huser CA, Gilroy KL, de Ridder J, Kilbey A, Borland G, Mackay N, Jenkins A, Bell M, Herzyk P, van der Weyden L, Adams DJ, Rust AG, Cameron E, Neil JC. PMID: 24586197; PMCID: PMC3937229.
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    99. Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels. Biochem Pharmacol. 2014 May 15; 89(2):276-86. Klint JK, Berecki G, Durek T, Mobli M, Knapp O, King GF, Adams DJ, Alewood PF, Rash LD. PMID: 24561180.
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    100. Inactivating CUX1 mutations promote tumorigenesis. Nat Genet. 2014 Jan; 46(1):33-8. Wong CC, Martincorena I, Rust AG, Rashid M, Alifrangis C, Alexandrov LB, Tiffen JC, Kober C, Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium, Green AR, Massie CE, Nangalia J, Lempidaki S, Döhner H, Döhner K, Bray SJ, McDermott U, Papaemmanuil E, Campbell PJ, Adams DJ. PMID: 24316979; PMCID: PMC3874239.
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    101. Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model. Nat Genet. 2014 Jan; 46(1):24-32. Bard-Chapeau EA, Nguyen AT, Rust AG, Sayadi A, Lee P, Chua BQ, New LS, de Jong J, Ward JM, Chin CK, Chew V, Toh HC, Abastado JP, Benoukraf T, Soong R, Bard FA, Dupuy AJ, Johnson RL, Radda GK, Chan EC, Wessels LF, Adams DJ, Jenkins NA, Copeland NG. PMID: 24316982; PMCID: PMC4131144.
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    102. Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroups. Proc Natl Acad Sci U S A. 2013 Nov 12; 110(46):E4325-34. Genovesi LA, Ng CG, Davis MJ, Remke M, Taylor MD, Adams DJ, Rust AG, Ward JM, Ban KH, Jenkins NA, Copeland NG, Wainwright BJ. PMID: 24167280; PMCID: PMC3832011.
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    103. Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors. J Biol Chem. 2013 Nov 29; 288(48):34428-42. Grishin AA, Cuny H, Hung A, Clark RJ, Brust A, Akondi K, Alewood PF, Craik DJ, Adams DJ. PMID: 24100032; PMCID: PMC3843058.
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    104. Cancer gene discovery: exploiting insertional mutagenesis. Mol Cancer Res. 2013 Oct; 11(10):1141-58. Ranzani M, Annunziato S, Adams DJ, Montini E. PMID: 23928056; PMCID: PMC3836224.
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    105. Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors. Biochem Pharmacol. 2013 Sep 15; 86(6):791-9. Inserra MC, Kompella SN, Vetter I, Brust A, Daly NL, Cuny H, Craik DJ, Alewood PF, Adams DJ, Lewis RJ. PMID: 23924607.
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    106. Identification of a neuronal transcription factor network involved in medulloblastoma development. Acta Neuropathol Commun. 2013 Jul 11; 1:35. Lastowska M, Al-Afghani H, Al-Balool HH, Sheth H, Mercer E, Coxhead JM, Redfern CP, Peters H, Burt AD, Santibanez-Koref M, Bacon CM, Chesler L, Rust AG, Adams DJ, Williamson D, Clifford SC, Jackson MS. PMID: 24252690; PMCID: PMC3893591.
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    107. Cake: a bioinformatics pipeline for the integrated analysis of somatic variants in cancer genomes. Bioinformatics. 2013 Sep 01; 29(17):2208-10. Rashid M, Robles-Espinoza CD, Rust AG, Adams DJ. PMID: 23803469; PMCID: PMC3740632.
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    108. Dicarba α-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors. ACS Chem Biol. 2013 Aug 16; 8(8):1815-21. van Lierop BJ, Robinson SD, Kompella SN, Belgi A, McArthur JR, Hung A, MacRaild CA, Adams DJ, Norton RS, Robinson AJ. PMID: 23768016.
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    109. Analysis of tumor heterogeneity and cancer gene networks using deep sequencing of MMTV-induced mouse mammary tumors. PLoS One. 2013; 8(5):e62113. Klijn C, Koudijs MJ, Kool J, ten Hoeve J, Boer M, de Moes J, Akhtar W, van Miltenburg M, Vendel-Zwaagstra A, Reinders MJ, Adams DJ, van Lohuizen M, Hilkens J, Wessels LF, Jonkers J. PMID: 23690930; PMCID: PMC3653918.
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    110. Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor. J Med Chem. 2013 May 09; 56(9):3557-67. Yu R, Kompella SN, Adams DJ, Craik DJ, Kaas Q. PMID: 23566299.
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    111. Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1. ACS Chem Biol. 2013; 8(6):1215-22. Durek T, Vetter I, Wang CI, Motin L, Knapp O, Adams DJ, Lewis RJ, Alewood PF. PMID: 23527544.
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    112. Mechanisms of conotoxin inhibition of N-type (Ca(v)2.2) calcium channels. Biochim Biophys Acta. 2013 Jul; 1828(7):1619-28. Adams DJ, Berecki G. PMID: 23380425.
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    113. Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome. PLoS Genet. 2012; 8(11):e1003022. McIntyre RE, Lakshminarasimhan Chavali P, Ismail O, Carragher DM, Sanchez-Andrade G, Forment JV, Fu B, Del Castillo Velasco-Herrera M, Edwards A, van der Weyden L, Yang F, Sanger Mouse Genetics Project, Ramirez-Solis R, Estabel J, Gallagher FA, Logan DW, Arends MJ, Tsang SH, Mahajan VB, Scudamore CL, White JK, Jackson SP, Gergely F, Adams DJ. PMID: 23166506; PMCID: PMC3499256.
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    114. Conotoxins targeting neuronal voltage-gated sodium channel subtypes: potential analgesics? Toxins (Basel). 2012 Nov 08; 4(11):1236-60. Knapp O, McArthur JR, Adams DJ. PMID: 23202314; PMCID: PMC3509706.
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    115. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature. 2012 Nov 15; 491(7424):399-405. Biankin AV, Waddell N, Kassahn KS, Gingras MC, Muthuswamy LB, Johns AL, Miller DK, Wilson PJ, Patch AM, Wu J, Chang DK, Cowley MJ, Gardiner BB, Song S, Harliwong I, Idrisoglu S, Nourse C, Nourbakhsh E, Manning S, Wani S, Gongora M, Pajic M, Scarlett CJ, Gill AJ, Pinho AV, Rooman I, Anderson M, Holmes O, Leonard C, Taylor D, Wood S, Xu Q, Nones K, Fink JL, Christ A, Bruxner T, Cloonan N, Kolle G, Newell F, Pinese M, Mead RS, Humphris JL, Kaplan W, Jones MD, Colvin EK, Nagrial AM, Humphrey ES, Chou A, Chin VT, Chantrill LA, Mawson A, Samra JS, Kench JG, Lovell JA, Daly RJ, Merrett ND, Toon C, Epari K, Nguyen NQ, Barbour A, Zeps N, Australian Pancreatic Cancer Genome Initiative, Kakkar N, Zhao F, Wu YQ, Wang M, Muzny DM, Fisher WE, Brunicardi FC, Hodges SE, Reid JG, Drummond J, Chang K, Han Y, Lewis LR, Dinh H, Buhay CJ, Beck T, Timms L, Sam M, Begley K, Brown A, Pai D, Panchal A, Buchner N, De Borja R, Denroche RE, Yung CK, Serra S, Onetto N, Mukhopadhyay D, Tsao MS, Shaw PA, Petersen GM, Gallinger S, Hruban RH, Maitra A, Iacobuzio-Donahue CA, Schulick RD, Wolfgang CL, Morgan RA, Lawlor RT, Capelli P, Corbo V, Scardoni M, Tortora G, Tempero MA, Mann KM, Jenkins NA, Perez-Mancera PA, Adams DJ, Largaespada DA, Wessels LF, Rust AG, Stein LD, Tuveson DA, Copeland NG, Musgrove EA, Scarpa A, Eshleman JR, Hudson TJ, Sutherland RL, Wheeler DA, Pearson JV, McPherson JD, Gibbs RA, Grimmond SM. PMID: 23103869; PMCID: PMC3530898.
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    117. Generation of the Sotos syndrome deletion in mice. Mamm Genome. 2012 Dec; 23(11-12):749-57. Migdalska AM, van der Weyden L, Ismail O, Sanger Mouse Genetics Project, Rust AG, Rashid M, White JK, Sánchez-Andrade G, Lupski JR, Logan DW, Arends MJ, Adams DJ. PMID: 22926222; PMCID: PMC3510424.
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    118. Loss of RASSF1A synergizes with deregulated RUNX2 signaling in tumorigenesis. Cancer Res. 2012 Aug 01; 72(15):3817-3827. van der Weyden L, Papaspyropoulos A, Poulogiannis G, Rust AG, Rashid M, Adams DJ, Arends MJ, O'Neill E. PMID: 22710434; PMCID: PMC4067151.
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    120. γ-Aminobutyric acid type B (GABAB) receptor expression is needed for inhibition of N-type (Cav2.2) calcium channels by analgesic α-conotoxins. J Biol Chem. 2012 Jul 06; 287(28):23948-57. Cuny H, de Faoite A, Huynh TG, Yasuda T, Berecki G, Adams DJ. PMID: 22613715; PMCID: PMC3390670.
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    121. Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels. Biochem Pharmacol. 2012 Aug 15; 84(4):540-8. Vetter I, Dekan Z, Knapp O, Adams DJ, Alewood PF, Lewis RJ. PMID: 22609441.
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    122. Increased tumorigenesis associated with loss of the tumor suppressor gene Cadm1. Mol Cancer. 2012 May 03; 11:29. van der Weyden L, Arends MJ, Rust AG, Poulogiannis G, McIntyre RE, Adams DJ. PMID: 22553910; PMCID: PMC3489691.
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    123. Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (Ca(V) 2.2) calcium channels. Br J Pharmacol. 2012 May; 166(2):486-500. Adams DJ, Callaghan B, Berecki G. PMID: 22091786; PMCID: PMC3417482.
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    124. The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature. 2012 Apr 29; 486(7402):266-70. Pérez-Mancera PA, Rust AG, van der Weyden L, Kristiansen G, Li A, Sarver AL, Silverstein KA, Grützmann R, Aust D, Rümmele P, Knösel T, Herd C, Stemple DL, Kettleborough R, Brosnan JA, Li A, Morgan R, Knight S, Yu J, Stegeman S, Collier LS, ten Hoeve JJ, de Ridder J, Klein AP, Goggins M, Hruban RH, Chang DK, Biankin AV, Grimmond SM, Australian Pancreatic Cancer Genome Initiative, Wessels LF, Wood SA, Iacobuzio-Donahue CA, Pilarsky C, Largaespada DA, Adams DJ, Tuveson DA. PMID: 22699621; PMCID: PMC3376394.
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    125. Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation. EMBO J. 2012 May 30; 31(11):2486-97. Wilson CH, Crombie C, van der Weyden L, Poulogiannis G, Rust AG, Pardo M, Gracia T, Yu L, Choudhary J, Poulin GB, McIntyre RE, Winton DJ, March HN, Arends MJ, Fraser AG, Adams DJ. PMID: 22510880; PMCID: PMC3365428.
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    126. An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model. Blood. 2012 May 10; 119(19):4512-23. Bergerson RJ, Collier LS, Sarver AL, Been RA, Lugthart S, Diers MD, Zuber J, Rappaport AR, Nixon MJ, Silverstein KA, Fan D, Lamblin AF, Wolff L, Kersey JH, Delwel R, Lowe SW, O'Sullivan MG, Kogan SC, Adams DJ, Largaespada DA. PMID: 22427200; PMCID: PMC3362364.
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    127. Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma. Proc Natl Acad Sci U S A. 2012 Apr 17; 109(16):5934-41. Mann KM, Ward JM, Yew CC, Kovochich A, Dawson DW, Black MA, Brett BT, Sheetz TE, Dupuy AJ, Australian Pancreatic Cancer Genome Initiative, Chang DK, Biankin AV, Waddell N, Kassahn KS, Grimmond SM, Rust AG, Adams DJ, Jenkins NA, Copeland NG. PMID: 22421440; PMCID: PMC3341075.
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    128. Localization of Nav 1.7 in the normal and injured rodent olfactory system indicates a critical role in olfaction, pheromone sensing and immune function. Channels (Austin). 2012 Mar-Apr; 6(2):103-10. Rupasinghe DB, Knapp O, Blomster LV, Schmid AB, Adams DJ, King GF, Ruitenberg MJ. PMID: 22622154.
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    129. The fine-scale architecture of structural variants in 17 mouse genomes. Genome Biol. 2012; 13(3):R18. Yalcin B, Wong K, Bhomra A, Goodson M, Keane TM, Adams DJ, Flint J. PMID: 22439878; PMCID: PMC3439969.
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    130. RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs. Biochem Pharmacol. 2012 Feb 01; 83(3):419-26. Franco A, Kompella SN, Akondi KB, Melaun C, Daly NL, Luetje CW, Alewood PF, Craik DJ, Adams DJ, Marí F. PMID: 22108175.
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    131. Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis. Nat Genet. 2011 Nov 06; 43(12):1202-9. March HN, Rust AG, Wright NA, ten Hoeve J, de Ridder J, Eldridge M, van der Weyden L, Berns A, Gadiot J, Uren A, Kemp R, Arends MJ, Wessels LF, Winton DJ, Adams DJ. PMID: 22057237; PMCID: PMC3233530.
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    132. In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. Cell. 2011 Oct 14; 147(2):382-95. Karreth FA, Tay Y, Perna D, Ala U, Tan SM, Rust AG, DeNicola G, Webster KA, Weiss D, Perez-Mancera PA, Krauthammer M, Halaban R, Provero P, Adams DJ, Tuveson DA, Pandolfi PP. PMID: 22000016; PMCID: PMC3236086.
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    133. Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABA(B) receptor. J Med Chem. 2011 Oct 13; 54(19):6984-92. Halai R, Callaghan B, Daly NL, Clark RJ, Adams DJ, Craik DJ. PMID: 21888386.
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    134. Computational identification of insertional mutagenesis targets for cancer gene discovery. Nucleic Acids Res. 2011 Aug; 39(15):e105. de Jong J, de Ridder J, van der Weyden L, Sun N, van Uitert M, Berns A, van Lohuizen M, Jonkers J, Adams DJ, Wessels LF. PMID: 21652642; PMCID: PMC3159484.
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    135. Purification of immature neuronal cells from neural stem cell progeny. PLoS One. 2011; 6(6):e20941. Azari H, Osborne GW, Yasuda T, Golmohammadi MG, Rahman M, Deleyrolle LP, Esfandiari E, Adams DJ, Scheffler B, Steindler DA, Reynolds BA. PMID: 21687800; PMCID: PMC3109004.
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    136. Modeling the evolution of ETV6-RUNX1-induced B-cell precursor acute lymphoblastic leukemia in mice. Blood. 2011 Jul 28; 118(4):1041-51. van der Weyden L, Giotopoulos G, Rust AG, Matheson LS, van Delft FW, Kong J, Corcoran AE, Greaves MF, Mullighan CG, Huntly BJ, Adams DJ. PMID: 21628403; PMCID: PMC3622520.
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    137. Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding. Angew Chem Int Ed Engl. 2011 Jul 11; 50(29):6527-9. de Araujo AD, Callaghan B, Nevin ST, Daly NL, Craik DJ, Moretta M, Hopping G, Christie MJ, Adams DJ, Alewood PF. PMID: 21630402.
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    138. Embryonic toxin expression in the cone snail Conus victoriae: primed to kill or divergent function? J Biol Chem. 2011 Jun 24; 286(25):22546-57. Safavi-Hemami H, Siero WA, Kuang Z, Williamson NA, Karas JA, Page LR, MacMillan D, Callaghan B, Kompella SN, Adams DJ, Norton RS, Purcell AW. PMID: 21504902; PMCID: PMC3121399.
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    139. Acute sensitivity of the oral mucosa to oncogenic K-ras. J Pathol. 2011 May; 224(1):22-32. van der Weyden L, Alcolea MP, Jones PH, Rust AG, Arends MJ, Adams DJ. PMID: 21381032; PMCID: PMC3627303.
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    140. Structure and activity of alpha-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABA(B) receptor-coupled N-type calcium channels. J Biol Chem. 2011 Mar 25; 286(12):10233-7. Daly NL, Callaghan B, Clark RJ, Nevin ST, Adams DJ, Craik DJ. PMID: 21252227; PMCID: PMC3060477.
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    141. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature. 2011 Jan 27; 469(7331):539-42. Varela I, Tarpey P, Raine K, Huang D, Ong CK, Stephens P, Davies H, Jones D, Lin ML, Teague J, Bignell G, Butler A, Cho J, Dalgliesh GL, Galappaththige D, Greenman C, Hardy C, Jia M, Latimer C, Lau KW, Marshall J, McLaren S, Menzies A, Mudie L, Stebbings L, Largaespada DA, Wessels LF, Richard S, Kahnoski RJ, Anema J, Tuveson DA, Perez-Mancera PA, Mustonen V, Fischer A, Adams DJ, Rust A, Chan-on W, Subimerb C, Dykema K, Furge K, Campbell PJ, Teh BT, Stratton MR, Futreal PA. PMID: 21248752; PMCID: PMC3030920.
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    142. Regulation of voltage-gated ion channels in excitable cells by the ubiquitin ligases Nedd4 and Nedd4-2. Channels (Austin). 2011 Jan-Feb; 5(1):79-88. Bongiorno D, Schuetz F, Poronnik P, Adams DJ. PMID: 21057195.
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    143. The engineering of an orally active conotoxin for the treatment of neuropathic pain. Angew Chem Int Ed Engl. 2010 Sep 03; 49(37):6545-8. Clark RJ, Jensen J, Nevin ST, Callaghan BP, Adams DJ, Craik DJ. PMID: 20533477.
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    144. Stabilization of α-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization. Antioxid Redox Signal. 2011 Jan 01; 14(1):87-95. Lovelace ES, Gunasekera S, Alvarmo C, Clark RJ, Nevin ST, Grishin AA, Adams DJ, Craik DJ, Daly NL. PMID: 20486767.
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    145. Slingshot: a PiggyBac based transposon system for tamoxifen-inducible 'self-inactivating' insertional mutagenesis. Nucleic Acids Res. 2010 Oct; 38(18):e173. Kong J, Wang F, Brenton JD, Adams DJ. PMID: 20688953; PMCID: PMC2952874.
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    146. Alpha-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of alpha3beta4 nicotinic acetylcholine receptors. J Biol Chem. 2010 Jul 16; 285(29):22254-63. Grishin AA, Wang CI, Muttenthaler M, Alewood PF, Lewis RJ, Adams DJ. PMID: 20466726; PMCID: PMC2903359.
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    147. Solving the alpha-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antagonists. J Am Chem Soc. 2010 Mar 17; 132(10):3514-22. Muttenthaler M, Nevin ST, Grishin AA, Ngo ST, Choy PT, Daly NL, Hu SH, Armishaw CJ, Wang CI, Lewis RJ, Martin JL, Noakes PG, Craik DJ, Adams DJ, Alewood PF. PMID: 20163143.
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    148. Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach. Cancer Res. 2010 Feb 01; 70(3):883-95. Mattison J, Kool J, Uren AG, de Ridder J, Wessels L, Jonkers J, Bignell GR, Butler A, Rust AG, Brosch M, Wilson CH, van der Weyden L, Largaespada DA, Stratton MR, Futreal PA, van Lohuizen M, Berns A, Collier LS, Hubbard T, Adams DJ. PMID: 20103622; PMCID: PMC2880710.
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    149. Analgesic α-conotoxins Vc1.1 and RgIA inhibit N-type calcium channels in sensory neurons of α9 nicotinic receptor knockout mice. Channels (Austin). 2010 Jan-Feb; 4(1):51-4. Callaghan B, Adams DJ. PMID: 20368690.
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    150. Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality. Cancer Res. 2009 Nov 01; 69(21):8429-37. Collier LS, Adams DJ, Hackett CS, Bendzick LE, Akagi K, Davies MN, Diers MD, Rodriguez FJ, Bender AM, Tieu C, Matise I, Dupuy AJ, Copeland NG, Jenkins NA, Hodgson JG, Weiss WA, Jenkins RB, Largaespada DA. PMID: 19843846; PMCID: PMC2771123.
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    151. Deep short-read sequencing of chromosome 17 from the mouse strains A/J and CAST/Ei identifies significant germline variation and candidate genes that regulate liver triglyceride levels. Genome Biol. 2009; 10(10):R112. Sudbery I, Stalker J, Simpson JT, Keane T, Rust AG, Hurles ME, Walter K, Lynch D, Teboul L, Brown SD, Li H, Ning Z, Nadeau JH, Croniger CM, Durbin R, Adams DJ. PMID: 19825173; PMCID: PMC2784327.
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    152. Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha9alpha10 nicotinic acetylcholine receptor. J Biol Chem. 2009 Jul 24; 284(30):20275-84. Halai R, Clark RJ, Nevin ST, Jensen JE, Adams DJ, Craik DJ. PMID: 19447885; PMCID: PMC2740453.
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    153. A high-throughput splinkerette-PCR method for the isolation and sequencing of retroviral insertion sites. Nat Protoc. 2009; 4(5):789-98. Uren AG, Mikkers H, Kool J, van der Weyden L, Lund AH, Wilson CH, Rance R, Jonkers J, van Lohuizen M, Berns A, Adams DJ. PMID: 19528954; PMCID: PMC3627465.
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    154. Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3. Toxicon. 2009 Jul; 54(1):56-61. Jensen JE, Durek T, Alewood PF, Adams DJ, King GF, Rash LD. PMID: 19306891.
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    155. Cancer gene discovery in mouse and man. Biochim Biophys Acta. 2009 Dec; 1796(2):140-61. Mattison J, van der Weyden L, Hubbard T, Adams DJ. PMID: 19285540; PMCID: PMC2756404.
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    156. Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues. J Biol Chem. 2009 Feb 20; 284(8):4944-51. Millard EL, Nevin ST, Loughnan ML, Nicke A, Clark RJ, Alewood PF, Lewis RJ, Adams DJ, Craik DJ, Daly NL. PMID: 19098004.
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    157. Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation. J Neurosci. 2008 Oct 22; 28(43):10943-51. Callaghan B, Haythornthwaite A, Berecki G, Clark RJ, Craik DJ, Adams DJ. PMID: 18945902; PMCID: PMC6671365.
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    158. Molecular engineering of conotoxins: the importance of loop size to alpha-conotoxin structure and function. J Med Chem. 2008 Sep 25; 51(18):5575-84. Jin AH, Daly NL, Nevin ST, Wang CI, Dutertre S, Lewis RJ, Adams DJ, Craik DJ, Alewood PF. PMID: 18754612.
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    159. omega-Conotoxin inhibition of excitatory synaptic transmission evoked by dorsal root stimulation in rat superficial dorsal horn. Neuropharmacology. 2008 Oct; 55(5):860-4. Motin L, Adams DJ. PMID: 18644398.
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    160. Neuronally micro-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels. J Biol Chem. 2008 Aug 01; 283(31):21621-8. Schroeder CI, Ekberg J, Nielsen KJ, Adams D, Loughnan ML, Thomas L, Adams DJ, Alewood PF, Lewis RJ. PMID: 18522941.
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    161. Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks. Cell. 2008 May 16; 133(4):727-41. Uren AG, Kool J, Matentzoglu K, de Ridder J, Mattison J, van Uitert M, Lagcher W, Sie D, Tanger E, Cox T, Reinders M, Hubbard TJ, Rogers J, Jonkers J, Wessels L, Adams DJ, van Lohuizen M, Berns A. PMID: 18485879; PMCID: PMC2405818.
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    162. Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by serum- and glucocorticoid-regulated kinase-1. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C73-80. Schuetz F, Kumar S, Poronnik P, Adams DJ. PMID: 18463232.
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    163. The three-dimensional structure of the analgesic alpha-conotoxin, RgIA. FEBS Lett. 2008 Mar 05; 582(5):597-602. Clark RJ, Daly NL, Halai R, Nevin ST, Adams DJ, Craik DJ. PMID: 18242183.
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    164. K(ir) and K(v) channels regulate electrical properties and proliferation of adult neural precursor cells. Mol Cell Neurosci. 2008 Feb; 37(2):284-97. Yasuda T, Bartlett PF, Adams DJ. PMID: 18023363.
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    165. Polymodal regulation of NMDA receptor channels. Channels (Austin). 2007 Sep-Oct; 1(5):334-43. Kloda A, Martinac B, Adams DJ. PMID: 18690040.
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    166. Chemical modification of conotoxins to improve stability and activity. ACS Chem Biol. 2007 Jul 20; 2(7):457-68. Craik DJ, Adams DJ. PMID: 17649970.
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    167. Purinergic receptor activation inhibits mitogen-stimulated proliferation in primary neurospheres from the adult mouse subventricular zone. Mol Cell Neurosci. 2007 Aug; 35(4):535-48. Stafford MR, Bartlett PF, Adams DJ. PMID: 17553694.
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    168. Structure of alpha-conotoxin BuIA: influences of disulfide connectivity on structural dynamics. BMC Struct Biol. 2007 Apr 20; 7:28. Jin AH, Brandstaetter H, Nevin ST, Tan CC, Clark RJ, Adams DJ, Alewood PF, Craik DJ, Daly NL. PMID: 17445276; PMCID: PMC1865545.
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    169. The doublecortin-expressing population in the developing and adult brain contains multipotential precursors in addition to neuronal-lineage cells. J Neurosci. 2007 Apr 04; 27(14):3734-42. Walker TL, Yasuda T, Adams DJ, Bartlett PF. PMID: 17409237; PMCID: PMC6672401.
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    170. Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2. J Biol Chem. 2007 Apr 20; 282(16):12135-42. Ekberg J, Schuetz F, Boase NA, Conroy SJ, Manning J, Kumar S, Poronnik P, Adams DJ. PMID: 17322297.
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    171. Liposome reconstitution and modulation of recombinant N-methyl-D-aspartate receptor channels by membrane stretch. Proc Natl Acad Sci U S A. 2007 Jan 30; 104(5):1540-5. Kloda A, Lua L, Hall R, Adams DJ, Martinac B. PMID: 17242368; PMCID: PMC1780071.
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    172. Omega-conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels. Eur J Neurosci. 2007 Jan; 25(2):435-44. Motin L, Yasuda T, Schroeder CI, Lewis RJ, Adams DJ. PMID: 17284184.
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    173. Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels. Mol Pharmacol. 2007 Mar; 71(3):676-85. Lewis RJ, Schroeder CI, Ekberg J, Nielsen KJ, Loughnan M, Thomas L, Adams DA, Drinkwater R, Adams DJ, Alewood PF. PMID: 17142296.
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    174. Identification of a novel class of nicotinic receptor antagonists: dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum. J Biol Chem. 2006 Aug 25; 281(34):24745-55. Loughnan M, Nicke A, Jones A, Schroeder CI, Nevin ST, Adams DJ, Alewood PF, Lewis RJ. PMID: 16790424.
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    175. The synthesis, structural characterization, and receptor specificity of the alpha-conotoxin Vc1.1. J Biol Chem. 2006 Aug 11; 281(32):23254-63. Clark RJ, Fischer H, Nevin ST, Adams DJ, Craik DJ. PMID: 16754662.
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    176. Alpha-selenoconotoxins, a new class of potent alpha7 neuronal nicotinic receptor antagonists. J Biol Chem. 2006 May 19; 281(20):14136-43. Armishaw CJ, Daly NL, Nevin ST, Adams DJ, Craik DJ, Alewood PF. PMID: 16500898.
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    177. Engineering stable peptide toxins by means of backbone cyclization: stabilization of the alpha-conotoxin MII. Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39):13767-72. Clark RJ, Fischer H, Dempster L, Daly NL, Rosengren KJ, Nevin ST, Meunier FA, Adams DJ, Craik DJ. PMID: 16162671; PMCID: PMC1236553.
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    178. Tertiapin-Q blocks recombinant and native large conductance K+ channels in a use-dependent manner. J Pharmacol Exp Ther. 2005 Sep; 314(3):1353-61. Kanjhan R, Coulson EJ, Adams DJ, Bellingham MC. PMID: 15947038.
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    179. Selective modulation of neuronal nicotinic acetylcholine receptor channel subunits by Go-protein subunits. J Neurosci. 2005 Apr 06; 25(14):3571-7. Fischer H, Liu DM, Lee A, Harries JC, Adams DJ. PMID: 15814787; PMCID: PMC6725378.
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    180. Developmental changes in expression of GABAA receptor-channels in rat intrinsic cardiac ganglion neurones. J Physiol. 2005 Apr 15; 564(Pt 2):465-74. Fischer H, Harper AA, Anderson CR, Adams DJ. PMID: 15731187; PMCID: PMC1464452.
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    181. Voltage-dependent inhibition of recombinant NMDA receptor-mediated currents by 5-hydroxytryptamine. Br J Pharmacol. 2005 Feb; 144(3):323-30. Kloda A, Adams DJ. PMID: 15655527; PMCID: PMC1576009.
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    182. Intravenous anaesthetics inhibit nicotinic acetylcholine receptor-mediated currents and Ca2+ transients in rat intracardiac ganglion neurons. Br J Pharmacol. 2005 Jan; 144(1):98-107. Weber M, Motin L, Gaul S, Beker F, Fink RH, Adams DJ. PMID: 15644873; PMCID: PMC1575970.
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    183. Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases. Chem Biol. 2005 Jan; 12(1):65-76. Rao FV, Houston DR, Boot RG, Aerts JM, Hodkinson M, Adams DJ, Shiomi K, Omura S, van Aalten DM. PMID: 15664516.
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    184. BRCTx is a novel, highly conserved RAD18-interacting protein. Mol Cell Biol. 2005 Jan; 25(2):779-88. Adams DJ, van der Weyden L, Gergely FV, Arends MJ, Ng BL, Tannahill D, Kanaar R, Markus A, Morris BJ, Bradley A. PMID: 15632077; PMCID: PMC543416.
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    185. Auxiliary subunit regulation of high-voltage activated calcium channels expressed in mammalian cells. Eur J Neurosci. 2004 Jul; 20(1):1-13. Yasuda T, Chen L, Barr W, McRory JE, Lewis RJ, Adams DJ, Zamponi GW. PMID: 15245474.
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    186. Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-methyl-D-aspartate receptors. Mol Pharmacol. 2004 Jun; 65(6):1386-96. Kloda A, Clements JD, Lewis RJ, Adams DJ. PMID: 15155832.
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    187. The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels. J Biol Chem. 2004 Aug 13; 279(33):34705-14. Mould J, Yasuda T, Schroeder CI, Beedle AM, Doering CJ, Zamponi GW, Adams DJ, Lewis RJ. PMID: 15166237.
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    188. Potassium channels and membrane potential in the modulation of intracellular calcium in vascular endothelial cells. J Cardiovasc Electrophysiol. 2004 May; 15(5):598-610. Adams DJ, Hill MA. PMID: 15149433.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    189. Functional maturation of isolated neural progenitor cells from the adult rat hippocampus. Eur J Neurosci. 2004 May; 19(9):2410-20. Hogg RC, Chipperfield H, Whyte KA, Stafford MR, Hansen MA, Cool SM, Nurcombe V, Adams DJ. PMID: 15128395.
      View in: PubMed   Mentions: 25  Translation:AnimalsCells
    190. Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2. J Biol Chem. 2004 Jul 09; 279(28):28930-5. Fotia AB, Ekberg J, Adams DJ, Cook DI, Poronnik P, Kumar S. PMID: 15123669.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    191. Structures of muO-conotoxins from Conus marmoreus. I nhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons. J Biol Chem. 2004 Jun 11; 279(24):25774-82. Daly NL, Ekberg JA, Thomas L, Adams DJ, Lewis RJ, Craik DJ. PMID: 15044438.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    192. Overexpressed Ca(v)beta3 inhibits N-type (Cav2.2) calcium channel currents through a hyperpolarizing shift of ultra-slow and closed-state inactivation. J Gen Physiol. 2004 Apr; 123(4):401-16. Yasuda T, Lewis RJ, Adams DJ. PMID: 15024042; PMCID: PMC2217459.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    193. Chemical and functional identification and characterization of novel sulfated alpha-conotoxins from the cone snail Conus anemone. J Med Chem. 2004 Feb 26; 47(5):1234-41. Loughnan ML, Nicke A, Jones A, Adams DJ, Alewood PF, Lewis RJ. PMID: 14971903.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    194. HADHB, HuR, and CP1 bind to the distal 3'-untranslated region of human renin mRNA and differentially modulate renin expression. J Biol Chem. 2003 Nov 07; 278(45):44894-903. Adams DJ, Beveridge DJ, van der Weyden L, Mangs H, Leedman PJ, Morris BJ. PMID: 12933794.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    195. Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of action, Na+ dependence, and structure-activity relationship. J Biol Chem. 2003 Oct 10; 278(41):40317-23. Sharpe IA, Palant E, Schroeder CI, Kaye DM, Adams DJ, Alewood PF, Lewis RJ. PMID: 12885787.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    196. Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA. J Biol Chem. 2003 Sep 05; 278(36):34451-7. Sharpe IA, Thomas L, Loughnan M, Motin L, Palant E, Croker DE, Alewood D, Chen S, Graham RM, Alewood PF, Adams DJ, Lewis RJ. PMID: 12824165.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    197. Muscarinic and nicotinic ACh receptor activation differentially mobilize Ca2+ in rat intracardiac ganglion neurons. J Neurophysiol. 2003 Sep; 90(3):1956-64. Beker F, Weber M, Fink RH, Adams DJ. PMID: 12761283.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    198. Alpha-conotoxins PnIA and [A10L]PnIA stabilize different states of the alpha7-L247T nicotinic acetylcholine receptor. J Biol Chem. 2003 Jul 18; 278(29):26908-14. Hogg RC, Hopping G, Alewood PF, Adams DJ, Bertrand D. PMID: 12746432.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    199. Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of alpha-conotoxin MII. J Med Chem. 2003 Mar 27; 46(7):1266-72. Blanchfield JT, Dutton JL, Hogg RC, Gallagher OP, Craik DJ, Jones A, Adams DJ, Lewis RJ, Alewood PF, Toth I. PMID: 12646037.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    200. The structure of the zinc finger domain from human splicing factor ZNF265 fold. J Biol Chem. 2003 Jun 20; 278(25):22805-11. Plambeck CA, Kwan AH, Adams DJ, Westman BJ, van der Weyden L, Medcalf RL, Morris BJ, Mackay JP. PMID: 12657633.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    201. Omega-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals. J Biol Chem. 2003 Feb 07; 278(6):4057-62. Adams DJ, Smith AB, Schroeder CI, Yasuda T, Lewis RJ. PMID: 12441339.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    202. Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence. J Biol Chem. 2003 Jan 31; 278(5):3137-44. Nicke A, Loughnan ML, Millard EL, Alewood PF, Adams DJ, Daly NL, Craik DJ, Lewis RJ. PMID: 12419800.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    203. A new level of conotoxin diversity, a non-native disulfide bond connectivity in alpha-conotoxin AuIB reduces structural definition but increases biological activity. J Biol Chem. 2002 Dec 13; 277(50):48849-57. Dutton JL, Bansal PS, Hogg RC, Adams DJ, Alewood PF, Craik DJ. PMID: 12376538.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    204. Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels. J Biol Chem. 2002 Jul 26; 277(30):27247-55. Nielsen KJ, Watson M, Adams DJ, Hammarström AK, Gage PW, Hill JM, Craik DJ, Thomas L, Adams D, Alewood PF, Lewis RJ. PMID: 12006587.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    205. Human non-pregnancy ribonuclease with anti-Kaposi's sarcoma activity. Cancer Lett. 2002 Feb 25; 176(2):183-9. Al-Owais MM, Hesse L, Talbot SJ, Adams DJ. PMID: 11804746.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
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