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Klassen, Henry John

Title(s)Associate Professor In Residence, Ophthalmology
Phone(949) 824-0710
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    Collapse Research 
    Collapse Research Activities and Funding
    Characterization of transgenic neural stem cells
    NIH/NINDS R21NS044060Jul 5, 2002 - Jun 30, 2005
    Role: Principal Investigator
    FUNCTION OF TRANSPLANTS TO THE OUTER RETINA
    NIH/NEI F32EY006697Mar 30, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yang J, Menges S, Gu P, Tongbai R, Samuel M, Prather RS, Klassen H. Porcine Neural Progenitor Cells Derived from Tissue at Different Gestational Ages Can Be Distinguished by Global Transcriptome. Cell Transplant. 2017 09; 26(9):1582-1595. PMID: 29113465.
      View in: PubMed
    2. Cooper AE, Cho JH, Menges S, Masood S, Xie J, Yang J, Klassen H. Immunosuppressive Treatment Can Alter Visual Performance in the Royal College of Surgeons Rat. J Ocul Pharmacol Ther. 2016 06; 32(5):296-303. PMID: 27008099.
      View in: PubMed
    3. Klassen H. Stem cells in clinical trials for treatment of retinal degeneration. Expert Opin Biol Ther. 2016; 16(1):7-14. PMID: 26414165.
      View in: PubMed
    4. Tucker BA, Park IH, Qi SD, Klassen HJ, Jiang C, Yao J, Redenti S, Daley GQ, Young MJ. Correction: Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice. PLoS One. 2015; 10(5):e0125947. PMID: 25950705.
      View in: PubMed
    5. Sheu J, Klassen H, Bauer G. Cellular manufacturing for clinical applications. Dev Ophthalmol. 2014; 53:178-88. PMID: 24732771.
      View in: PubMed
    6. Qin Z, Yang J, Klassen HJ, Aswad DW. Isoaspartyl protein damage and repair in mouse retina. Invest Ophthalmol Vis Sci. 2014 Mar 13; 55(3):1572-9. PMID: 24550364.
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    7. Yang J, Gu P, Menges S, Klassen H. Quantitative changes in gene transcription during induction of differentiation in porcine neural progenitor cells. Mol Vis. 2012; 18:1484-504. PMID: 22736940; PMCID: PMC3380908.
    8. Klassen H, Tucker BA, Liew CG, La Cour M, Wang HC. Stem cells in large animal models of retinal and neurological disease. Stem Cells Int. 2012; 2012:460504. PMID: 22666270.
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    9. Yang J, Wang J, Gu P, You XJ, Klassen H. Feline Neural Progenitor Cells I: Long-Term Expansion under Defined Culture Conditions. Stem Cells Int. 2012; 2012:108340. PMID: 22577394.
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    10. Klassen H, Kiilgaard JF, Warfvinge K, Samuel MS, Prather RS, Wong F, Petters RM, la Cour M, Young MJ. Photoreceptor Differentiation following Transplantation of Allogeneic Retinal Progenitor Cells to the Dystrophic Rhodopsin Pro347Leu Transgenic Pig. Stem Cells Int. 2012; 2012:939801. PMID: 22567027.
      View in: PubMed
    11. Torrez LB, Perez Y, Yang J, Zur Nieden NI, Klassen H, Liew CG. Derivation of neural progenitors and retinal pigment epithelium from common marmoset and human pluripotent stem cells. Stem Cells Int. 2012; 2012:417865. PMID: 22550507.
      View in: PubMed
    12. You XJ, Yang J, Gu P, Liew CG, Klassen HJ. Feline neural progenitor cells II: use of novel plasmid vector and hybrid promoter to drive expression of glial cell line-derived neurotrophic factor transgene. Stem Cells Int. 2012; 2012:604982. PMID: 22550512.
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    13. Christiansen AT, Tao SL, Smith M, Wnek GE, Prause JU, Young MJ, Klassen H, Kaplan HJ, la Cour M, Kiilgaard JF. Subretinal implantation of electrospun, short nanowire, and smooth poly(e-caprolactone) scaffolds to the subretinal space of porcine eyes. Stem Cells Int. 2012; 2012:454295. PMID: 22550509.
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    14. Christiansen AT, Kiilgaard JF, Smith M, Ejstrup R, Wnek GE, Prause JU, Young MJ, Klassen H, Kaplan H, La Cour M. The influence of brightness on functional assessment by mferg: a study on scaffolds used in retinal cell transplantation in pigs. Stem Cells Int. 2012; 2012:263264. PMID: 22550501.
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    15. Klassen H. New tool for retinal degeneration research. Invest Ophthalmol Vis Sci. 2012 Feb 01; 53(2):926. PMID: 22345364.
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    16. Warfvinge K, Schwartz PH, Kiilgaard JF, la Cour M, Young MJ, Scherfig E, Klassen H. Xenotransplantation of human neural progenitor cells to the subretinal space of nonimmunosuppressed pigs. J Transplant. 2011; 2011:948740. PMID: 21766011.
      View in: PubMed
    17. Tucker BA, Park IH, Qi SD, Klassen HJ, Jiang C, Yao J, Redenti S, Daley GQ, Young MJ. Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice. PLoS One. 2011 Apr 29; 6(4):e18992. PMID: 21559507.
      View in: PubMed
    18. Wang J, Yang J, Gu P, Klassen H. Effects of glial cell line-derived neurotrophic factor on cultured murine retinal progenitor cells. Mol Vis. 2010 Dec 31; 16:2850-66. PMID: 21203407.
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    19. Ejstrup R, Kiilgaard JF, Tucker BA, Klassen HJ, Young MJ, La Cour M. Pharmacokinetics of intravitreal glial cell line-derived neurotrophic factor: experimental studies in pigs. Exp Eye Res. 2010 Dec; 91(6):890-5. PMID: 20883692.
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    20. You XJ, Gu P, Wang J, Song T, Yang J, Liew CG, Klassen H. Efficient transduction of feline neural progenitor cells for delivery of glial cell line-derived neurotrophic factor using a feline immunodeficiency virus-based lentiviral construct. J Ophthalmol. 2011; 2011. PMID: 20936061.
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    21. Cho SJ, Lee YS, Lee JI, Bang JI, Yang J, Klassen H, Kong IK. Confirmation of germ-line transmission in the red fluorescence protein (RFP) transgenic cloned male cat. Cell Reprogram. 2010 Dec; 12(6):739-47. PMID: 20818992.
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    22. Sodha S, Wall K, Redenti S, Klassen H, Young MJ, Tao SL. Microfabrication of a three-dimensional polycaprolactone thin-film scaffold for retinal progenitor cell encapsulation. J Biomater Sci Polym Ed. 2011; 22(4-6):443-56. PMID: 20566039.
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    23. Jiang C, Klassen H, Zhang X, Young M. Laser injury promotes migration and integration of retinal progenitor cells into host retina. Mol Vis. 2010 Jun 04; 16:983-90. PMID: 20577598.
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    24. Steedman MR, Tao SL, Klassen H, Desai TA. Enhanced differentiation of retinal progenitor cells using microfabricated topographical cues. Biomed Microdevices. 2010 Jun; 12(3):363-9. PMID: 20077017; PMCID: PMC2859162.
    25. Gu P, Yang J, Wang J, Young MJ, Klassen H. Sequential changes in the gene expression profile of murine retinal progenitor cells during the induction of differentiation. Mol Vis. 2009 Oct 20; 15:2111-22. PMID: 19862338.
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    26. Tucker BA, Redenti SM, Jiang C, Swift JS, Klassen HJ, Smith ME, Wnek GE, Young MJ. The use of progenitor cell/biodegradable MMP2-PLGA polymer constructs to enhance cellular integration and retinal repopulation. Biomaterials. 2010 Jan; 31(1):9-19. PMID: 19775744.
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    27. Kyhn MV, Klassen H, Johansson UE, Warfvinge K, Lavik E, Kiilgaard JF, Prause JU, Scherfig E, Young M, la Cour M. Delayed administration of glial cell line-derived neurotrophic factor (GDNF) protects retinal ganglion cells in a pig model of acute retinal ischemia. Exp Eye Res. 2009 Dec; 89(6):1012-20. PMID: 19735654.
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    28. Schmitt S, Aftab U, Jiang C, Redenti S, Klassen H, Miljan E, Sinden J, Young M. Molecular characterization of human retinal progenitor cells. Invest Ophthalmol Vis Sci. 2009 Dec; 50(12):5901-8. PMID: 19553622.
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    29. Aftab U, Jiang C, Tucker B, Kim JY, Klassen H, Miljan E, Sinden J, Young M. Growth kinetics and transplantation of human retinal progenitor cells. Exp Eye Res. 2009 Sep; 89(3):301-10. PMID: 19524569.
      View in: PubMed
    30. Redenti S, Neeley WL, Rompani S, Saigal S, Yang J, Klassen H, Langer R, Young MJ. Engineering retinal progenitor cell and scrollable poly(glycerol-sebacate) composites for expansion and subretinal transplantation. Biomaterials. 2009 Jul; 30(20):3405-14. PMID: 19361860.
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    31. Kyhn MV, Warfvinge K, Scherfig E, Kiilgaard JF, Prause JU, Klassen H, Young M, la Cour M. Acute retinal ischemia caused by controlled low ocular perfusion pressure in a porcine model. Electrophysiological and histological characterisation. Exp Eye Res. 2009 Jun; 88(6):1100-6. PMID: 19450446.
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    32. Yang J, Klassen H, Pries M, Wang W, Nissen MH. Vitreous humor and albumin augment the proliferation of cultured retinal precursor cells. J Neurosci Res. 2009 Feb; 87(2):495-502. PMID: 18803297.
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    33. Klassen H, Warfvinge K, Schwartz PH, Kiilgaard JF, Shamie N, Jiang C, Samuel M, Scherfig E, Prather RS, Young MJ. Isolation of progenitor cells from GFP-transgenic pigs and transplantation to the retina of allorecipients. Cloning Stem Cells. 2008 Sep; 10(3):391-402. PMID: 18729769.
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    34. Redenti S, Tao S, Yang J, Gu P, Klassen H, Saigal S, Desai T, Young MJ. Retinal tissue engineering using mouse retinal progenitor cells and a novel biodegradable, thin-film poly(e-caprolactone) nanowire scaffold. J Ocul Biol Dis Infor. 2008 Mar; 1(1):19-29. PMID: 20072632; PMCID: PMC2802414.
    35. Tucker B, Klassen H, Yang L, Chen DF, Young MJ. Elevated MMP Expression in the MRL Mouse Retina Creates a Permissive Environment for Retinal Regeneration. Invest Ophthalmol Vis Sci. 2008 Apr; 49(4):1686-95. PMID: 18385092.
      View in: PubMed
    36. Klassen H, Reubinoff B. Stem cells in a new light. Nat Biotechnol. 2008 Feb; 26(2):187-8. PMID: 18259172.
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    37. Neeley WL, Redenti S, Klassen H, Tao S, Desai T, Young MJ, Langer R. A microfabricated scaffold for retinal progenitor cell grafting. Biomaterials. 2008 Feb; 29(4):418-26. PMID: 17961646.
      View in: PubMed
    38. Jiang C, Moore MJ, Zhang X, Klassen H, Langer R, Young M. Intravitreal injections of GDNF-loaded biodegradable microspheres are neuroprotective in a rat model of glaucoma. Mol Vis. 2007 Sep 24; 13:1783-92. PMID: 17960131.
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    39. Klassen H, Schwartz PH, Ziaeian B, Nethercott H, Young MJ, Bragadottir R, Tullis GE, Warfvinge K, Narfstrom K. Neural precursors isolated from the developing cat brain show retinal integration following transplantation to the retina of the dystrophic cat. Vet Ophthalmol. 2007 Jul-Aug; 10(4):245-53. PMID: 17565557.
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    40. Hori J, Ng TF, Shatos M, Klassen H, Streilein JW, Young MJ. Neural progenitor cells lack immunogenicity and resist destruction as allografts. 2003. Ocul Immunol Inflamm. 2007 May-Jun; 15(3):261-73. PMID: 17613840.
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    41. Klassen H. Recruitment of endogenous neural progenitor cells by malignant neoplasms of the central nervous system. Curr Stem Cell Res Ther. 2007 May; 2(2):113-9. PMID: 18220896.
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    42. Zhang Y, Klassen HJ, Tucker BA, Perez MT, Young MJ. CNS progenitor cells promote a permissive environment for neurite outgrowth via a matrix metalloproteinase-2-dependent mechanism. J Neurosci. 2007 Apr 25; 27(17):4499-506. PMID: 17460063.
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    43. Tao S, Young C, Redenti S, Zhang Y, Klassen H, Desai T, Young MJ. Survival, migration and differentiation of retinal progenitor cells transplanted on micro-machined poly(methyl methacrylate) scaffolds to the subretinal space. Lab Chip. 2007 Jun; 7(6):695-701. PMID: 17538710.
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    44. Klassen H, Kiilgaard JF, Zahir T, Ziaeian B, Kirov I, Scherfig E, Warfvinge K, Young MJ. Progenitor cells from the porcine neural retina express photoreceptor markers after transplantation to the subretinal space of allorecipients. Stem Cells. 2007 May; 25(5):1222-30. PMID: 17218397.
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    45. Ng TF, Klassen HJ, Hori J, Young MJ. Retinal transplantation. Chem Immunol Allergy. 2007; 92:300-16. PMID: 17264505.
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    46. Zahir T, Klassen H, Tomita M, Young MJ. Sorbitol causes preferential selection of Muller glial precursors from late retinal progenitor cells in vitro. Mol Vis. 2006 Dec 20; 12:1606-14. PMID: 17200660.
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    47. Yang J, Klassen H, Pries M, Wang W, Nissen MH. Aqueous humor enhances the proliferation of rat retinal precursor cells in culture, and this effect is partially reproduced by ascorbic acid. Stem Cells. 2006 Dec; 24(12):2766-75. PMID: 16902197.
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    48. Young MJ, Klassen HJ. Polymeric delivery of neuroprotective compounds to the vitreous cavity: a potential treatment for glaucoma. Arch Soc Esp Oftalmol. 2006 Aug; 81(8):429-32. PMID: 16933165.
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    49. Klassen H. Transplantation of cultured progenitor cells to the mammalian retina. Expert Opin Biol Ther. 2006 May; 6(5):443-51. PMID: 16610975.
      View in: PubMed
    50. Warfvinge K, Kiilgaard JF, Klassen H, Zamiri P, Scherfig E, Streilein W, Prause JU, Young MJ. Retinal progenitor cell xenografts to the pig retina: immunological reactions. Cell Transplant. 2006; 15(7):603-12. PMID: 17176612.
      View in: PubMed
    51. Tomita M, Lavik E, Klassen H, Zahir T, Langer R, Young MJ. Biodegradable polymer composite grafts promote the survival and differentiation of retinal progenitor cells. Stem Cells. 2005 Nov-Dec; 23(10):1579-88. PMID: 16293582.
      View in: PubMed
    52. Warfvinge K, Kiilgaard JF, Lavik EB, Scherfig E, Langer R, Klassen HJ, Young MJ. Retinal progenitor cell xenografts to the pig retina: morphologic integration and cytochemical differentiation. Arch Ophthalmol. 2005 Oct; 123(10):1385-93. PMID: 16219730.
      View in: PubMed
    53. Schwartz PH, Nethercott H, Kirov II, Ziaeian B, Young MJ, Klassen H. Expression of neurodevelopmental markers by cultured porcine neural precursor cells. Stem Cells. 2005 Oct; 23(9):1286-94. PMID: 16100001.
      View in: PubMed
    54. Lavik EB, Klassen H, Warfvinge K, Langer R, Young MJ. Fabrication of degradable polymer scaffolds to direct the integration and differentiation of retinal progenitors. Biomaterials. 2005 Jun; 26(16):3187-96. PMID: 15603813.
      View in: PubMed
    55. Zahir T, Klassen H, Young MJ. Effects of ciliary neurotrophic factor on differentiation of late retinal progenitor cells. Stem Cells. 2005 Mar; 23(3):424-32. PMID: 15749937.
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    56. Klassen HJ, Ng TF, Kurimoto Y, Kirov I, Shatos M, Coffey P, Young MJ. Multipotent retinal progenitors express developmental markers, differentiate into retinal neurons, and preserve light-mediated behavior. Invest Ophthalmol Vis Sci. 2004 Nov; 45(11):4167-73. PMID: 15505071.
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    57. Klassen H, Ziaeian B, Kirov II, Young MJ, Schwartz PH. Isolation of retinal progenitor cells from post-mortem human tissue and comparison with autologous brain progenitors. J Neurosci Res. 2004 Aug 01; 77(3):334-43. PMID: 15248289.
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    58. Klassen H, Sakaguchi DS, Young MJ. Stem cells and retinal repair. Prog Retin Eye Res. 2004 Mar; 23(2):149-81. PMID: 15094129.
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    59. Schwartz PH, Bryant PJ, Fuja TJ, Su H, O'Dowd DK, Klassen H. Isolation and characterization of neural progenitor cells from post-mortem human cortex. J Neurosci Res. 2003 Dec 15; 74(6):838-51. PMID: 14648588.
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    60. Mizumoto H, Mizumoto K, Shatos MA, Klassen H, Young MJ. Retinal transplantation of neural progenitor cells derived from the brain of GFP transgenic mice. Vision Res. 2003 Jul; 43(16):1699-708. PMID: 12818339.
      View in: PubMed
    61. Klassen HJ, Imfeld KL, Kirov II, Tai L, Gage FH, Young MJ, Berman MA. Expression of cytokines by multipotent neural progenitor cells. Cytokine. 2003 May; 22(3-4):101-6. PMID: 12849709.
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    62. Klassen H, Imfeld KL, Ray J, Young MJ, Gage FH, Berman MA. The immunological properties of adult hippocampal progenitor cells. Vision Res. 2003 Apr; 43(8):947-56. PMID: 12668064.
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    63. Hori J, Ng TF, Shatos M, Klassen H, Streilein JW, Young MJ. Neural progenitor cells lack immunogenicity and resist destruction as allografts. Stem Cells. 2003; 21(4):405-16. PMID: 12832694.
      View in: PubMed
    64. Huncharek M, Kupelnick B, Klassen H. Maternal smoking during pregnancy and the risk of childhood brain tumors: a meta-analysis of 6566 subjects from twelve epidemiological studies. J Neurooncol. 2002 Mar; 57(1):51-7. PMID: 12125967.
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    65. Huncharek M, Kupelnick B, Klassen H. Paternal smoking during pregnancy and the risk of childhood brain tumors: results of a meta-analysis. In Vivo. 2001 Nov-Dec; 15(6):535-41. PMID: 11887341.
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    66. Klassen H, Schwartz MR, Bailey AH, Young MJ. Surface markers expressed by multipotent human and mouse neural progenitor cells include tetraspanins and non-protein epitopes. Neurosci Lett. 2001 Oct 26; 312(3):180-2. PMID: 11602340.
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    67. Whiteley SJ, Klassen H, Coffey PJ, Young MJ. Photoreceptor rescue after low-dose intravitreal IL-1beta injection in the RCS rat. Exp Eye Res. 2001 Oct; 73(4):557-68. PMID: 11825026.
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    68. Huncharek M, Klassen H, Kupelnick B. Dietary beta-carotene intake and the risk of epithelial ovarian cancer: a meta-analysis of 3,782 subjects from five observational studies. In Vivo. 2001 Jul-Aug; 15(4):339-43. PMID: 11695227.
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    69. Klassen H, Whiteley SJ, Young MJ, Lund RD. Graft location affects functional rescue following RPE cell transplantation in the RCS rat. Exp Neurol. 2001 May; 169(1):114-21. PMID: 11312564.
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    70. Mizumoto H, Mizumoto K, Whiteley SJ, Shatos M, Klassen H, Young MJ. Transplantation of human neural progenitor cells to the vitreous cavity of the Royal College of Surgeons rat. Cell Transplant. 2001 Mar-Apr; 10(2):223-33. PMID: 11332637.
      View in: PubMed
    71. Young MJ, Ray J, Whiteley SJ, Klassen H, Gage FH. Neuronal differentiation and morphological integration of hippocampal progenitor cells transplanted to the retina of immature and mature dystrophic rats. Mol Cell Neurosci. 2000 Sep; 16(3):197-205. PMID: 10995547.
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    72. Schnell L, Fearn S, Klassen H, Schwab ME, Perry VH. Acute inflammatory responses to mechanical lesions in the CNS: differences between brain and spinal cord. Eur J Neurosci. 1999 Oct; 11(10):3648-58. PMID: 10564372.
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    73. Sauvé Y, Klassen H, Whiteley SJ, Lund RD. Visual field loss in RCS rats and the effect of RPE cell transplantation. Exp Neurol. 1998 Aug; 152(2):243-50. PMID: 9710524.
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    74. Klassen H, Klassen MK, Huncharek M. Group B streptococcal meningitis presenting as stroke in a nondebilitated man. Yale J Biol Med. 1995 Jan-Apr; 68(1-2):1-6. PMID: 8748460.
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    75. Huncharek M, Klassen H, Klassen M. Splenic artery aneurysm and upper gastrointestinal bleeding in a nulliparous woman. A case history. Angiology. 1994 Aug; 45(8):733-5. PMID: 8048783.
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    76. Huncharek M, Klassen H. Acyclovir in varicella pneumonia in healthy adults. Respiration. 1993; 60(4):254-5. PMID: 8265885.
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    77. Klassen H, Lund RD. Parameters of retinal graft-mediated responses are related to underlying target innervation. Brain Res. 1990 Nov 19; 533(2):181-91. PMID: 2289140.
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    78. Klassen H, Lund RD. Retinal graft-mediated pupillary responses in rats: restoration of a reflex function in the mature mammalian brain. J Neurosci. 1990 Feb; 10(2):578-87. PMID: 2303861.
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    79. Klassen H, Lund RD. Anatomical and behavioral correlates of a xenograft-mediated pupillary reflex. Exp Neurol. 1988 Oct; 102(1):102-8. PMID: 2846337.
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    80. Klassen H, Lund RD. Retinal transplants can drive a pupillary reflex in host rat brains. Proc Natl Acad Sci U S A. 1987 Oct; 84(19):6958-60. PMID: 3477821.
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