Frithjof R. Kruggel

Title(s)Professor, Biomedical Engineering
SchoolSamueli School of Engineering
Address202 Rockwell Engineering Center
Zot 2715
Irvine CA 92697
Phone(949) 824-3729
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Analyzing the cortical fine structure as revealed by ex-vivo anatomical MRI. J Comp Neurol. 2023 Dec; 531(18):2146-2161. Kruggel F, Solodkin A. PMID: 37522626.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Gyral and sulcal connectivity in the human cerebral cortex. Cereb Cortex. 2023 04 04; 33(8):4216-4229. Kruggel F, Solodkin A. PMID: 36104856.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Heritability of Structural Patterning in the Human Cerebral Cortex. Neuroimage. 2020 11 01; 221:117169. Kruggel F, Solodkin A. PMID: 32693166.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    4. Determinants of structural segregation and patterning in the human cortex. Neuroimage. 2019 08 01; 196:248-260. Kruggel F, Solodkin A. PMID: 30995518.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. A Simple Measure for Acuity in Medical Images. IEEE Trans Image Process. 2018 Nov; 27(11):5225-5233. Kruggel F. PMID: 29994711.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. The macro-structural variability of the human neocortex. Neuroimage. 2018 05 15; 172:620-630. Kruggel F. PMID: 29410357.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    7. Newborn insula gray matter volume is prospectively associated with early life adiposity gain. Int J Obes (Lond). 2017 09; 41(9):1434-1439. Rasmussen JM, Entringer S, Kruggel F, Cooper DM, Styner M, Gilmore JH, Potkin SG, Wadhwa PD, Buss C. PMID: 28487552; PMCID: PMC5585030.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. The brain anatomy of attention-deficit/hyperactivity disorder in young adults - a magnetic resonance imaging study. PLoS One. 2017; 12(4):e0175433. Gehricke JG, Kruggel F, Thampipop T, Alejo SD, Tatos E, Fallon J, Muftuler LT. PMID: 28406942; PMCID: PMC5391018.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCTClinical Trials
    9. Analysis of longitudinal diffusion-weighted images in healthy and pathological aging: An ADNI study. J Neurosci Methods. 2017 02 15; 278:101-115. Kruggel F, Masaki F, Solodkin A, Alzheimer’s Disease Neuroimaging Initiative. PMID: 28057473.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    10. A novel maturation index based on neonatal diffusion tensor imaging reflects typical perinatal white matter development in humans. Int J Dev Neurosci. 2017 Feb; 56:42-51. Rasmussen JM, Kruggel F, Gilmore JH, Styner M, Entringer S, Consing KN, Potkin SG, Wadhwa PD, Buss C. PMID: 27988340; PMCID: PMC5316374.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    11. Quantitative mapping of the per-axon diffusion coefficients in brain white matter. Magn Reson Med. 2016 Apr; 75(4):1752-63. Kaden E, Kruggel F, Alexander DC. PMID: 25974332; PMCID: PMC4975722.
      View in: PubMed   Mentions: 95     Fields:    Translation:Humans
    12. In vivo parahippocampal white matter pathology as a biomarker of disease progression to Alzheimer's disease. J Comp Neurol. 2013 Dec 15; 521(18):4300-17. Solodkin A, Chen EE, Van Hoesen GW, Heimer L, Shereen A, Kruggel F, Mastrianni J. PMID: 23839862.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    13. Behavioral and neuroanatomical investigation of Highly Superior Autobiographical Memory (HSAM). Neurobiol Learn Mem. 2012 Jul; 98(1):78-92. LePort AK, Mattfeld AT, Dickinson-Anson H, Fallon JH, Stark CE, Kruggel F, Cahill L, McGaugh JL. PMID: 22652113; PMCID: PMC3764458.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    14. Cortical Surface Reconstruction from High-Resolution MR Brain Images. Int J Biomed Imaging. 2012; 2012:870196. Osechinskiy S, Kruggel F. PMID: 22481909; PMCID: PMC3296314.
      View in: PubMed   Mentions: 4  
    15. Nonparametric Bayesian inference of the fiber orientation distribution from diffusion-weighted MR images. Med Image Anal. 2012 May; 16(4):876-88. Kaden E, Kruggel F. PMID: 22381587.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    16. Empirical derivation of the reference region for computing diagnostic sensitive ¹⁸fluorodeoxyglucose ratios in Alzheimer's disease based on the ADNI sample. Biochim Biophys Acta. 2012 Mar; 1822(3):457-66. Rasmussen JM, Lakatos A, van Erp TG, Kruggel F, Keator DB, Fallon JT, Macciardi F, Potkin SG, Alzheimer's Disease Neuroimaging Initiative. PMID: 21958592; PMCID: PMC5849233.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    17. A reproducing kernel hilbert space approach for q-ball imaging. IEEE Trans Med Imaging. 2011 Nov; 30(11):1877-86. Kaden E, Kruggel F. PMID: 21609878.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    18. Deformable registration of histological sections to brain MR images using a hybrid boundary-based slice-to-volume approach. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:4876-9. Osechinskiy S, Kruggel F. PMID: 22255431.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. Slice-to-Volume Nonrigid Registration of Histological Sections to MR Images of the Human Brain. Anat Res Int. 2011; 2011:287860. Osechinskiy S, Kruggel F. PMID: 22567290; PMCID: PMC3335496.
      View in: PubMed   Mentions: 9  
    20. PDE-based reconstruction of the cerebral cortex from MR images. Annu Int Conf IEEE Eng Med Biol Soc. 2010; 2010:4278-83. Osechinskiy S, Kruggel F. PMID: 21095750.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    21. Impact of scanner hardware and imaging protocol on image quality and compartment volume precision in the ADNI cohort. Neuroimage. 2010 Feb 01; 49(3):2123-33. Kruggel F, Turner J, Muftuler LT, Alzheimer's Disease Neuroimaging Initiative. PMID: 19913626; PMCID: PMC2951115.
      View in: PubMed   Mentions: 61     Fields:    Translation:Humans
    22. Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. PLoS One. 2009 Aug 07; 4(8):e6501. Potkin SG, Guffanti G, Lakatos A, Turner JA, Kruggel F, Fallon JH, Saykin AJ, Orro A, Lupoli S, Salvi E, Weiner M, Macciardi F, Alzheimer's Disease Neuroimaging Initiative. PMID: 19668339; PMCID: PMC2719581.
      View in: PubMed   Mentions: 201     Fields:    Translation:Humans
    23. Effects of advanced aging on the neural correlates of successful recognition memory. Neuropsychologia. 2009 Apr; 47(5):1352-61. Wang TH, Kruggel F, Rugg MD. PMID: 19428399; PMCID: PMC2680799.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    24. Quantitative comparison of high-resolution MRI and myelin-stained histology of the human cerebral cortex. Annu Int Conf IEEE Eng Med Biol Soc. 2009; 2009:85-9. Osechinskiy S, Kruggel F. PMID: 19964920.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    25. Automatic segmentation of human brain sulci. Med Image Anal. 2008 Aug; 12(4):442-451. Yang F, Kruggel F. PMID: 18325826.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    26. Robust parametrization of brain surface meshes. Med Image Anal. 2008 Jun; 12(3):291-9. Kruggel F. PMID: 18226945.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    27. Texture-based segmentation of diffuse lesions of the brain's white matter. Neuroimage. 2008 Feb 01; 39(3):987-96. Kruggel F, Paul JS, Gertz HJ. PMID: 18006334.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    28. Texture anisotropy of the brain's white matter as revealed by anatomical MRI. IEEE Trans Med Imaging. 2007 May; 26(5):678-85. Kovalev V, Kruggel F. PMID: 17518062.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    29. MRI-based volumetry of head compartments: normative values of healthy adults. Neuroimage. 2006 Mar; 30(1):1-11. Kruggel F. PMID: 16289929.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    30. Quasi-real-time neurosurgery support by MRI processing via grid computing. Neurosurg Clin N Am. 2005 Jan; 16(1):65-75. Lippmann H, Kruggel F. PMID: 15561529.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    31. Structural correlates of mild cognitive impairment. Neurobiol Aging. 2004 Aug; 25(7):913-24. Wolf H, Hensel A, Kruggel F, Riedel-Heller SG, Arendt T, Wahlund LO, Gertz HJ. PMID: 15212845.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCTClinical Trials
    32. Does the pattern of atrophy of the Corpus callosum differ between patients with frontotemporal dementia and patients with Alzheimer's disease? Dement Geriatr Cogn Disord. 2004; 18(1):44-9. Hensel A, Ibach B, Muller U, Kruggel F, Kiefer M, Gertz HJ. PMID: 15084793.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    33. An object-based approach for detecting small brain lesions: application to Virchow-Robin spaces. IEEE Trans Med Imaging. 2004 Feb; 23(2):246-55. Descombes X, Kruggel F, Wollny G, Gertz HJ. PMID: 14964568.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    34. Analyzing the neocortical fine-structure. Med Image Anal. 2003 Sep; 7(3):251-64. Kruggel F, Brückner MK, Arendt T, Wiggins CJ, von Cramon DY. PMID: 12946467.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    35. Gender and age effects in structural brain asymmetry as measured by MRI texture analysis. Neuroimage. 2003 Jul; 19(3):895-905. Kovalev VA, Kruggel F, von Cramon DY. PMID: 12880818.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    36. Age dependency of the hemodynamic response as measured by functional near-infrared spectroscopy. Neuroimage. 2003 Jul; 19(3):555-64. Schroeter ML, Zysset S, Kruggel F, von Cramon DY. PMID: 12880787.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCTClinical Trials
    37. The relationship between head size and intracranial volume in elderly subjects. Brain Res. 2003 May 23; 973(1):74-80. Wolf H, Kruggel F, Hensel A, Wahlund LO, Arendt T, Gertz HJ. PMID: 12729955.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    38. Do quiescent arachnoid cysts alter CNS functional organization?: A fMRI and morphometric study. Neurology. 2002 Dec 24; 59(12):1935-9. Hund-Georgiadis M, Yves Von Cramon D, Kruggel F, Preul C. PMID: 12499486.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    39. Near-infrared spectroscopy can detect brain activity during a color-word matching Stroop task in an event-related design. Hum Brain Mapp. 2002 Sep; 17(1):61-71. Schroeter ML, Zysset S, Kupka T, Kruggel F, Yves von Cramon D. PMID: 12203689; PMCID: PMC6872032.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCTClinical Trials
    40. Computional cost of nonrigid registration algorithms based on fluid dynamics. IEEE Trans Med Imaging. 2002 Aug; 21(8):946-52. Wollny G, Kruggel F. PMID: 12472267.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    41. Morphometry of the corpus callosum in patients with questionable and mild dementia. J Neurol Neurosurg Psychiatry. 2002 Jul; 73(1):59-61. Hensel A, Wolf H, Kruggel F, Riedel-Heller SG, Nikolaus C, Arendt T, Gertz HJ. PMID: 12082047; PMCID: PMC1757286.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    42. ICA of fMRI group study data. Neuroimage. 2002 Jul; 16(3 Pt 1):551-63. Svensén M, Kruggel F, Benali H. PMID: 12169242.
      View in: PubMed   Mentions: 59     Fields:    Translation:Humans
    43. Estimating the effective degrees of freedom in univariate multiple regression analysis. Med Image Anal. 2002 Mar; 6(1):63-75. Kruggel F, Pélégrini-Issac M, Benali H. PMID: 11836135.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    44. Theta-power differences in patients with mild cognitive impairment under rest condition and during haptic tasks. Alzheimer Dis Assoc Disord. 2002 Jan-Mar; 16(1):40-8. Grunwald M, Busse F, Hensel A, Riedel-Heller S, Kruggel F, Arendt T, Wolf H, Gertz HJ. PMID: 11882748.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    45. Hemodynamic and electroencephalographic responses to illusory figures: recording of the evoked potentials during functional MRI. Neuroimage. 2001 Dec; 14(6):1327-36. Kruggel F, Herrmann CS, Wiggins CJ, von Cramon DY. PMID: 11707088.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    46. Segmentation of large brain lesions. IEEE Trans Med Imaging. 2001 Jul; 20(7):666-9. Hojjatoleslami SA, Kruggel F. PMID: 11465472.
      View in: PubMed   Mentions: 11     Fields:    
    47. Three-dimensional texture analysis of MRI brain datasets. IEEE Trans Med Imaging. 2001 May; 20(5):424-33. Kovalev VA, Kruggel F, Gertz HJ, von Cramon DY. PMID: 11403201.
      View in: PubMed   Mentions: 28     Fields:    
    48. Correlation between cortical theta activity and hippocampal volumes in health, mild cognitive impairment, and mild dementia. J Clin Neurophysiol. 2001 Mar; 18(2):178-84. Grunwald M, Busse F, Hensel A, Kruggel F, Riedel-Heller S, Wolf H, Arendt T, Gertz HJ. PMID: 11435810.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCTClinical Trials
    49. Hippocampal volume discriminates between normal cognition; questionable and mild dementia in the elderly. Neurobiol Aging. 2001 Mar-Apr; 22(2):177-86. Wolf H, Grunwald M, Kruggel F, Riedel-Heller SG, Angerhöfer S, Hojjatoleslami A, Hensel A, Arendt T, Gertz H. PMID: 11182467.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCTClinical Trials
    50. Improvement of source localization by dynamical systems based modeling (DSBM). Brain Topogr. 2001; 13(3):219-26. Uhl C, Hutt A, Kruggel F. PMID: 11302400.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    51. Nonlinear regression of functional MRI data: an item recognition task study. Neuroimage. 2000 Aug; 12(2):173-83. Kruggel F, Zysset S, von Cramon DY. PMID: 10913323.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    52. Recording of the event-related potentials during functional MRI at 3.0 Tesla field strength. Magn Reson Med. 2000 Aug; 44(2):277-82. Kruggel F, Wiggins CJ, Herrmann CS, von Cramon DY. PMID: 10918327.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    53. Detection of fixed points in spatiotemporal signals by a clustering method. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 2000 May; 61(5 Pt A):R4691-3. Hutt A, Svensén M, Kruggel F, Friedrich R. PMID: 11031503.
      View in: PubMed   Mentions: 1     Fields:    
    54. Probabilistic modeling of single-trial fMRI data. IEEE Trans Med Imaging. 2000 Jan; 19(1):25-35. Svensén M, Kruggel F, von Cramon DY. PMID: 10782616.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    55. Comparison of filtering methods for fMRI datasets. Neuroimage. 1999 Nov; 10(5):530-43. Kruggel F, von Cramon DY, Descombes X. PMID: 10547330.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    56. Modeling the hemodynamic response in single-trial functional MRI experiments. Magn Reson Med. 1999 Oct; 42(4):787-97. Kruggel F, von Cramon DY. PMID: 10502769.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    57. Alignment of magnetic-resonance brain datasets with the stereotactical coordinate system. Med Image Anal. 1999 Jun; 3(2):175-85. Kruggel F, Yves von Cramon D. PMID: 10711997.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    58. Transient Analysis of the Biomechanics of the Human Head with a High-Resolution 3D Finite Element Model. Comput Methods Biomech Biomed Engin. 1999; 2(1):49-64. Hartmann U, Kruggel F. PMID: 11264818.
      View in: PubMed   Mentions:    Fields:    
    59. Combining electrophysiological and hemodynamic measures of the auditory oddball. Psychophysiology. 1999 Jan; 36(1):142-7. Opitz B, Mecklinger A, Von Cramon DY, Kruggel F. PMID: 10098390.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCTClinical Trials
    60. Temporal properties of the hemodynamic response in functional MRI. Hum Brain Mapp. 1999; 8(4):259-71. Kruggel F, von Cramon DY. PMID: 10619419; PMCID: PMC6873324.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    61. Spatio-temporal fMRI analysis using Markov random fields. IEEE Trans Med Imaging. 1998 Dec; 17(6):1028-39. Descombes X, Kruggel F, von Cramon DY. PMID: 10048860.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    62. fMRI signal restoration using a spatio-temporal Markov Random Field preserving transitions. Neuroimage. 1998 Nov; 8(4):340-9. Descombes X, Kruggel F, von Cramon DY. PMID: 9811552.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    63. Modeling hemodynamic response for analysis of functional MRI time-series. Hum Brain Mapp. 1998; 6(4):283-300. Rajapakse JC, Kruggel F, Maisog JM, von Cramon DY. PMID: 9704266; PMCID: PMC6873384.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    64. A new concept for EEG/MEG signal analysis: detection of interacting spatial modes. Hum Brain Mapp. 1998; 6(3):137-49. Uhl C, Kruggel F, Opitz B, Yves von Cramon D. PMID: 9673669; PMCID: PMC6873359.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    65. Secondary parkinsonism due to focal substantia nigra lesions: a PET study with [18F]FDG and [18F]fluorodopa. Acta Neurol Scand. 1996 Jun; 93(6):387-92. Boecker H, Weindl A, Leenders K, Antonini A, Kuwert T, Kruggel F, Grafin von Einsiedel H, Conrad B. PMID: 8836298.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    66. Inhibitory and excitatory interhemispheric transfers between motor cortical areas in normal humans and patients with abnormalities of the corpus callosum. Brain. 1995 Apr; 118 ( Pt 2):429-40. Meyer BU, Röricht S, Gräfin von Einsiedel H, Kruggel F, Weindl A. PMID: 7735884.
      View in: PubMed   Mentions: 167     Fields:    Translation:Humans
    67. [Importance of antiphospholipid antibodies in cerebral ischemia]. Nervenarzt. 1993 Dec; 64(12):806-13. Kruggel F, Klingelhöfer J, Sander D, Conrad B. PMID: 8114982.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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