Steven Chessler | UCI Profiles

Chessler, Steven David

Title	Associate Professor
Institution	University of California, Irvine
Department	Medicine
Address	1001 Health Sciences Road CA 92697-3950
Phone	(949) 824-3578
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Research

Research Activities and Funding

Neuroligins and Neuroligin-Neurexin Interactions in Islet Beta Cell Function
NIH/NIDDK R01DK080971Jun 10, 2009 - Mar 31, 2014
Role: Principal Investigator

SERUM GAD65 AS A BIOMARKER OF ISLET INJURY, INSULITIS AND TRANSPLANT REJECTION
NIH/NIDDK R21DK077466Sep 30, 2006 - Aug 31, 2009
Role: Principal Investigator

GAD65 release in autoimmune diabetes
NIH/NIDDK R03DK065877Feb 1, 2004 - Feb 28, 2006
Role: Principal Investigator

GAD RELEASE FROM BETA CELLS IN TYPE 1 DIABETES
NIH/NIDDK K08DK002944Mar 1, 2001 - Feb 28, 2006
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.

List All | Timeline

Chessler S, Lee DE. Alarming increase in HbA1c and near misdiagnosis of diabetes mellitus resulting from a clinical laboratory instrument upgrade and haemoglobin variant. BMJ Case Rep. 2018 Jun 14; 2018. PMID: 29903779.

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Vallejo D, Lee SH, Lee D, Zhang C, Rapier C, Chessler S, Lee AP. Cell-sized lipid vesicles for cell-cell synaptic therapies. Technology (Singap World Sci). 2017 Dec; 5(4):201-213. PMID: 29744376.

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Munder A, Israel LL, Kahremany S, Ben-Shabat-Binyamini R, Zhang C, Kolitz-Domb M, Viskind O, Levine A, Senderowitz H, Chessler S, Lellouche JP, Gruzman A. Mimicking Neuroligin-2 Functions in ß-Cells by Functionalized Nanoparticles as a Novel Approach for Antidiabetic Therapy. ACS Appl Mater Interfaces. 2017 Jan 18; 9(2):1189-1206. PMID: 28045486.

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Zhang C, Caldwell TA, Mirbolooki MR, Duong D, Park EJ, Chi NW, Chessler S. Extracellular CADM1 interactions influence insulin secretion by rat and human islet ß-cells and promote clustering of syntaxin-1. Am J Physiol Endocrinol Metab. 2016 06 01; 310(11):E874-85. PMID: 27072493.

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Zhong L, Yeh TY, Hao J, Pourtabatabaei N, Mahata SK, Shao J, Chessler S, Chi NW. Nutritional energy stimulates NAD+ production to promote tankyrase-mediated PARsylation in insulinoma cells. PLoS One. 2015; 10(4):e0122948. PMID: 25876076; PMCID: PMC4395342.

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Zhang C, Suckow AT, Chessler S. Coculture analysis of extracellular protein interactions affecting insulin secretion by pancreatic beta cells. J Vis Exp. 2013 Jun 15; (76):e50365. PMID: 23793074; PMCID: PMC3727474.

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Zhang C, Suckow AT, Chessler S. Altered pancreatic islet function and morphology in mice lacking the Beta-cell surface protein neuroligin-2. PLoS One. 2013; 8(6):e65711. PMID: 23776533; PMCID: PMC3679192.

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Suckow AT, Zhang C, Egodage S, Comoletti D, Taylor P, Miller MT, Sweet IR, Chessler S. Transcellular neuroligin-2 interactions enhance insulin secretion and are integral to pancreatic ß cell function. J Biol Chem. 2012 Jun 08; 287(24):19816-26. PMID: 22528485; PMCID: PMC3370167.

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Mosedale M, Egodage S, Calma RC, Chi NW, Chessler S. Neurexin-1a contributes to insulin-containing secretory granule docking. J Biol Chem. 2012 Feb 24; 287(9):6350-61. PMID: 22235116; PMCID: PMC3307300.

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Suckow AT, Craige B, Faundez V, Cain WJ, Chessler S. An AP-3-dependent mechanism drives synaptic-like microvesicle biogenesis in pancreatic islet beta-cells. Am J Physiol Endocrinol Metab. 2010 Jul; 299(1):E23-32. PMID: 20442321; PMCID: PMC2904044.

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Suckow AT, Comoletti D, Waldrop MA, Mosedale M, Egodage S, Taylor P, Chessler S. Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion. Endocrinology. 2008 Dec; 149(12):6006-17. PMID: 18755801; PMCID: PMC2613060.

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Waldrop MA, Suckow AT, Marcovina SM, Chessler S. Release of glutamate decarboxylase-65 into the circulation by injured pancreatic islet beta-cells. Endocrinology. 2007 Oct; 148(10):4572-8. PMID: 17584960.

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Waldrop MA, Suckow AT, Hall TR, Hampe CS, Marcovina SM, Chessler S. A highly sensitive immunoassay resistant to autoantibody interference for detection of the diabetes-associated autoantigen glutamic acid decarboxylase 65 in blood and other biological samples. Diabetes Technol Ther. 2006 Apr; 8(2):207-18. PMID: 16734550.

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Suckow AT, Sweet IR, Van Yserloo B, Rutledge EA, Hall TR, Waldrop M, Chessler S. Identification and characterization of a novel isoform of the vesicular gamma-aminobutyric acid transporter with glucose-regulated expression in rat islets. J Mol Endocrinol. 2006 Feb; 36(1):187-99. PMID: 16461938.

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Chessler S, Hampe CS, Ortqvist E, Simonson WT, Bekris L. Immune reactivity to GAD25 in type 1 diabetes mellitus. Autoimmunity. 2002 Aug; 35(5):335-41. PMID: 12515288.

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Chessler S. Debt repayment for trainees. N Engl J Med. 2002 Jun 20; 346(25):2013; author reply 2014. PMID: 12075069.

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Chessler S, Simonson WT, Sweet IR, Hammerle LP. Expression of the vesicular inhibitory amino acid transporter in pancreatic islet cells: distribution of the transporter within rat islets. Diabetes. 2002 Jun; 51(6):1763-71. PMID: 12031963.

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Chessler S, Lernmark A. Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues. J Biol Chem. 2000 Feb 18; 275(7):5188-92. PMID: 10671565.

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