Steven David Chessler

Title(s)Professor Emeritus, Medicine
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
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    Collapse Research 
    Collapse Research Activities and Funding
    Neuroligins and Neuroligin-Neurexin Interactions in Islet Beta Cell Function
    NIH R01DK080971Jun 10, 2009 - Mar 31, 2016
    Role: Principal Investigator
    NIH R21DK077466Sep 30, 2006 - Aug 31, 2009
    Role: Principal Investigator
    GAD65 release in autoimmune diabetes
    NIH R03DK065877Feb 1, 2004 - Feb 28, 2006
    Role: Principal Investigator
    NIH K08DK002944Mar 1, 2001 - Feb 28, 2006
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The Portfolio Diet and Incident Type 2 Diabetes: Findings From the Women's Health Initiative Prospective Cohort Study. Diabetes Care. 2023 01 01; 46(1):28-37. Glenn AJ, Li J, Lo K, Jenkins DJA, Boucher BA, Hanley AJ, Kendall CWC, Shadyab AH, Tinker LF, Chessler SD, Howard BV, Liu S, Sievenpiper JL. PMID: 36162007; PMCID: PMC9797645.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    2. Safety and Efficacy of Lonapegsomatropin in Children With Growth Hormone Deficiency: enliGHten Trial 2-Year Results. J Clin Endocrinol Metab. 2022 06 16; 107(7):e2680-e2689. Maniatis AK, Casella SJ, Nadgir UM, Hofman PL, Saenger P, Chertock ED, Aghajanova EM, Korpal-Szczyrska M, Vlachopapadopoulou E, Malievskiy O, Chaychenko T, Cappa M, Song W, Mao M, Mygind PH, Smith AR, Chessler SD, Komirenko AS, Beckert M, Shu AD, Thornton PS. PMID: 35428884; PMCID: PMC9202697.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    3. Switching to Weekly Lonapegsomatropin from Daily Somatropin in Children with Growth Hormone Deficiency: The fliGHt Trial. Horm Res Paediatr. 2022; 95(3):233-243. Maniatis AK, Nadgir U, Saenger P, Reifschneider KL, Abuzzahab J, Deeb L, Fox LA, Woods KA, Song W, Mao M, Chessler SD, Komirenko AS, Shu AD, Casella SJ, Thornton PS. PMID: 35263755; PMCID: PMC9501775.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    4. Neuroligin-2-derived peptide-covered polyamidoamine-based (PAMAM) dendrimers enhance pancreatic β-cells' proliferation and functions. Medchemcomm. 2019 Feb 01; 10(2):280-293. Munder A, Moskovitz Y, Meir A, Kahremany S, Levy L, Kolitz-Domb M, Cohen G, Shtriker E, Viskind O, Lellouche JP, Senderowitz H, Chessler SD, Korshin EE, Ruthstein S, Gruzman A. PMID: 30881615; PMCID: PMC6390468.
      View in: PubMed   Mentions: 2  
    5. Alarming increase in HbA1c and near misdiagnosis of diabetes mellitus resulting from a clinical laboratory instrument upgrade and haemoglobin variant. BMJ Case Rep. 2018 Jun 14; 2018. Chessler SD, Lee DE. PMID: 29903779; PMCID: PMC6011579.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    6. Cell-sized lipid vesicles for cell-cell synaptic therapies. Technology (Singap World Sci). 2017 Dec; 5(4):201-213. Vallejo D, Lee SH, Lee D, Zhang C, Rapier C, Chessler SD, Lee AP. PMID: 29744376; PMCID: PMC5937847.
      View in: PubMed   Mentions: 2  
    7. Mimicking Neuroligin-2 Functions in β-Cells by Functionalized Nanoparticles as a Novel Approach for Antidiabetic Therapy. ACS Appl Mater Interfaces. 2017 Jan 18; 9(2):1189-1206. Munder A, Israel LL, Kahremany S, Ben-Shabat-Binyamini R, Zhang C, Kolitz-Domb M, Viskind O, Levine A, Senderowitz H, Chessler S, Lellouche JP, Gruzman A. PMID: 28045486; PMCID: PMC6035049.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    8. Extracellular CADM1 interactions influence insulin secretion by rat and human islet β-cells and promote clustering of syntaxin-1. Am J Physiol Endocrinol Metab. 2016 06 01; 310(11):E874-85. Zhang C, Caldwell TA, Mirbolooki MR, Duong D, Park EJ, Chi NW, Chessler SD. PMID: 27072493; PMCID: PMC4935136.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    9. Nutritional energy stimulates NAD+ production to promote tankyrase-mediated PARsylation in insulinoma cells. PLoS One. 2015; 10(4):e0122948. Zhong L, Yeh TY, Hao J, Pourtabatabaei N, Mahata SK, Shao J, Chessler SD, Chi NW. PMID: 25876076; PMCID: PMC4395342.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    10. Coculture analysis of extracellular protein interactions affecting insulin secretion by pancreatic beta cells. J Vis Exp. 2013 Jun 15; (76):e50365. Zhang C, Suckow AT, Chessler SD. PMID: 23793074; PMCID: PMC3727474.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    11. Altered pancreatic islet function and morphology in mice lacking the Beta-cell surface protein neuroligin-2. PLoS One. 2013; 8(6):e65711. Zhang C, Suckow AT, Chessler SD. PMID: 23776533; PMCID: PMC3679192.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    12. Transcellular neuroligin-2 interactions enhance insulin secretion and are integral to pancreatic β cell function. J Biol Chem. 2012 Jun 08; 287(24):19816-26. Suckow AT, Zhang C, Egodage S, Comoletti D, Taylor P, Miller MT, Sweet IR, Chessler SD. PMID: 22528485; PMCID: PMC3370167.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    13. Neurexin-1α contributes to insulin-containing secretory granule docking. J Biol Chem. 2012 Feb 24; 287(9):6350-61. Mosedale M, Egodage S, Calma RC, Chi NW, Chessler SD. PMID: 22235116; PMCID: PMC3307300.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    14. An AP-3-dependent mechanism drives synaptic-like microvesicle biogenesis in pancreatic islet beta-cells. Am J Physiol Endocrinol Metab. 2010 Jul; 299(1):E23-32. Suckow AT, Craige B, Faundez V, Cain WJ, Chessler SD. PMID: 20442321; PMCID: PMC2904044.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    15. Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion. Endocrinology. 2008 Dec; 149(12):6006-17. Suckow AT, Comoletti D, Waldrop MA, Mosedale M, Egodage S, Taylor P, Chessler SD. PMID: 18755801; PMCID: PMC2613060.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    16. Release of glutamate decarboxylase-65 into the circulation by injured pancreatic islet beta-cells. Endocrinology. 2007 Oct; 148(10):4572-8. Waldrop MA, Suckow AT, Marcovina SM, Chessler SD. PMID: 17584960.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    17. A highly sensitive immunoassay resistant to autoantibody interference for detection of the diabetes-associated autoantigen glutamic acid decarboxylase 65 in blood and other biological samples. Diabetes Technol Ther. 2006 Apr; 8(2):207-18. Waldrop MA, Suckow AT, Hall TR, Hampe CS, Marcovina SM, Chessler SD. PMID: 16734550.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    18. Identification and characterization of a novel isoform of the vesicular gamma-aminobutyric acid transporter with glucose-regulated expression in rat islets. J Mol Endocrinol. 2006 Feb; 36(1):187-99. Suckow AT, Sweet IR, Van Yserloo B, Rutledge EA, Hall TR, Waldrop M, Chessler SD. PMID: 16461938.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    19. Immune reactivity to GAD25 in type 1 diabetes mellitus. Autoimmunity. 2002 Aug; 35(5):335-41. Chessler SD, Hampe CS, Ortqvist E, Simonson WT, Bekris L. PMID: 12515288.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    20. Debt repayment for trainees. N Engl J Med. 2002 Jun 20; 346(25):2013; author reply 2014. Chessler SD. PMID: 12075069.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Expression of the vesicular inhibitory amino acid transporter in pancreatic islet cells: distribution of the transporter within rat islets. Diabetes. 2002 Jun; 51(6):1763-71. Chessler SD, Simonson WT, Sweet IR, Hammerle LP. PMID: 12031963.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    22. Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues. J Biol Chem. 2000 Feb 18; 275(7):5188-92. Chessler SD, Lernmark A. PMID: 10671565.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    23. Association between baseline plasma leptin levels and subsequent development of diabetes in Japanese Americans. Diabetes Care. 1999 Jan; 22(1):65-70. McNeely MJ, Boyko EJ, Weigle DS, Shofer JB, Chessler SD, Leonnetti DL, Fujimoto WY. PMID: 10333905.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    24. Increased plasma leptin levels are associated with fat accumulation in Japanese Americans. Diabetes. 1998 Feb; 47(2):239-43. Chessler SD, Fujimoto WY, Shofer JB, Boyko EJ, Weigle DS. PMID: 9519719.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    25. Endoplasmic reticulum-mediated quality control of type I collagen production by cells from osteogenesis imperfecta patients with mutations in the pro alpha 1 (I) chain carboxyl-terminal propeptide which impair subunit assembly. J Biol Chem. 1995 Apr 14; 270(15):8642-9. Lamandé SR, Chessler SD, Golub SB, Byers PH, Chan D, Cole WG, Sillence DO, Bateman JF. PMID: 7721766.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    26. Mutations in the carboxyl-terminal propeptide of the pro alpha 1(I) chain of type I collagen result in defective chain association and produce lethal osteogenesis imperfecta. J Biol Chem. 1993 Aug 25; 268(24):18218-25. Chessler SD, Wallis GA, Byers PH. PMID: 8349697.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    27. BiP binds type I procollagen pro alpha chains with mutations in the carboxyl-terminal propeptide synthesized by cells from patients with osteogenesis imperfecta. J Biol Chem. 1993 Aug 25; 268(24):18226-33. Chessler SD, Byers PH. PMID: 8349698.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    28. Defective folding and stable association with protein disulfide isomerase/prolyl hydroxylase of type I procollagen with a deletion in the pro alpha 2(I) chain that preserves the Gly-X-Y repeat pattern. J Biol Chem. 1992 Apr 15; 267(11):7751-7. Chessler SD, Byers PH. PMID: 1339453.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    29. Group practice retains personal touch. Dent Surv. 1975 Oct; 51(10):87, 90-1. Chessler S, Goldberg SM, Wasserstein AH. PMID: 1073142.
      View in: PubMed   Mentions:    Fields:    
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