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Steven David Chessler

Title(s)Associate Professor, Medicine
Phone(949) 824-3578
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    Neuroligins and Neuroligin-Neurexin Interactions in Islet Beta Cell Function
    NIH/NIDDK R01DK080971Jun 10, 2009 - Mar 31, 2014
    Role: Principal Investigator
    SERUM GAD65 AS A BIOMARKER OF ISLET INJURY, INSULITIS AND TRANSPLANT REJECTION
    NIH/NIDDK R21DK077466Sep 30, 2006 - Aug 31, 2009
    Role: Principal Investigator
    GAD65 release in autoimmune diabetes
    NIH/NIDDK R03DK065877Feb 1, 2004 - Nov 30, 2004
    Role: Principal Investigator
    GAD RELEASE FROM BETA CELLS IN TYPE 1 DIABETES
    NIH/NIDDK K08DK002944Mar 1, 2001 - Feb 28, 2006
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Munder A, Moskovitz Y, Meir A, Kahremany S, Levy L, Kolitz-Domb M, Cohen G, Shtriker E, Viskind O, Lellouche JP, Senderowitz H, Chessler SD, Korshin EE, Ruthstein S, Gruzman A. Neuroligin-2-derived peptide-covered polyamidoamine-based (PAMAM) dendrimers enhance pancreatic ß-cells' proliferation and functions. Medchemcomm. 2019 Feb 01; 10(2):280-293. PMID: 30881615.
      View in: PubMed
    2. Chessler SD, Lee DE. Alarming increase in HbA1c and near misdiagnosis of diabetes mellitus resulting from a clinical laboratory instrument upgrade and haemoglobin variant. BMJ Case Rep. 2018 Jun 14; 2018. PMID: 29903779.
      View in: PubMed
    3. Vallejo D, Lee SH, Lee D, Zhang C, Rapier C, Chessler SD, Lee AP. Cell-sized lipid vesicles for cell-cell synaptic therapies. Technology (Singap World Sci). 2017 Dec; 5(4):201-213. PMID: 29744376.
      View in: PubMed
    4. Munder A, Israel LL, Kahremany S, Ben-Shabat-Binyamini R, Zhang C, Kolitz-Domb M, Viskind O, Levine A, Senderowitz H, Chessler S, Lellouche JP, Gruzman A. Mimicking Neuroligin-2 Functions in ß-Cells by Functionalized Nanoparticles as a Novel Approach for Antidiabetic Therapy. ACS Appl Mater Interfaces. 2017 Jan 18; 9(2):1189-1206. PMID: 28045486.
      View in: PubMed
    5. Zhang C, Caldwell TA, Mirbolooki MR, Duong D, Park EJ, Chi NW, Chessler SD. Extracellular CADM1 interactions influence insulin secretion by rat and human islet ß-cells and promote clustering of syntaxin-1. Am J Physiol Endocrinol Metab. 2016 06 01; 310(11):E874-85. PMID: 27072493.
      View in: PubMed
    6. Zhong L, Yeh TY, Hao J, Pourtabatabaei N, Mahata SK, Shao J, Chessler SD, Chi NW. Nutritional energy stimulates NAD+ production to promote tankyrase-mediated PARsylation in insulinoma cells. PLoS One. 2015; 10(4):e0122948. PMID: 25876076.
      View in: PubMed
    7. Zhang C, Suckow AT, Chessler SD. Coculture analysis of extracellular protein interactions affecting insulin secretion by pancreatic beta cells. J Vis Exp. 2013 Jun 15; (76):e50365. PMID: 23793074.
      View in: PubMed
    8. Zhang C, Suckow AT, Chessler SD. Altered pancreatic islet function and morphology in mice lacking the Beta-cell surface protein neuroligin-2. PLoS One. 2013; 8(6):e65711. PMID: 23776533.
      View in: PubMed
    9. Suckow AT, Zhang C, Egodage S, Comoletti D, Taylor P, Miller MT, Sweet IR, Chessler SD. Transcellular neuroligin-2 interactions enhance insulin secretion and are integral to pancreatic ß cell function. J Biol Chem. 2012 Jun 08; 287(24):19816-26. PMID: 22528485.
      View in: PubMed
    10. Mosedale M, Egodage S, Calma RC, Chi NW, Chessler SD. Neurexin-1a contributes to insulin-containing secretory granule docking. J Biol Chem. 2012 Feb 24; 287(9):6350-61. PMID: 22235116.
      View in: PubMed
    11. Suckow AT, Craige B, Faundez V, Cain WJ, Chessler SD. An AP-3-dependent mechanism drives synaptic-like microvesicle biogenesis in pancreatic islet beta-cells. Am J Physiol Endocrinol Metab. 2010 Jul; 299(1):E23-32. PMID: 20442321.
      View in: PubMed
    12. Suckow AT, Comoletti D, Waldrop MA, Mosedale M, Egodage S, Taylor P, Chessler SD. Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion. Endocrinology. 2008 Dec; 149(12):6006-17. PMID: 18755801.
      View in: PubMed
    13. Waldrop MA, Suckow AT, Marcovina SM, Chessler SD. Release of glutamate decarboxylase-65 into the circulation by injured pancreatic islet beta-cells. Endocrinology. 2007 Oct; 148(10):4572-8. PMID: 17584960.
      View in: PubMed
    14. Waldrop MA, Suckow AT, Hall TR, Hampe CS, Marcovina SM, Chessler SD. A highly sensitive immunoassay resistant to autoantibody interference for detection of the diabetes-associated autoantigen glutamic acid decarboxylase 65 in blood and other biological samples. Diabetes Technol Ther. 2006 Apr; 8(2):207-18. PMID: 16734550.
      View in: PubMed
    15. Suckow AT, Sweet IR, Van Yserloo B, Rutledge EA, Hall TR, Waldrop M, Chessler SD. Identification and characterization of a novel isoform of the vesicular gamma-aminobutyric acid transporter with glucose-regulated expression in rat islets. J Mol Endocrinol. 2006 Feb; 36(1):187-99. PMID: 16461938.
      View in: PubMed
    16. Chessler SD, Hampe CS, Ortqvist E, Simonson WT, Bekris L. Immune reactivity to GAD25 in type 1 diabetes mellitus. Autoimmunity. 2002 Aug; 35(5):335-41. PMID: 12515288.
      View in: PubMed
    17. Chessler SD. Debt repayment for trainees. N Engl J Med. 2002 Jun 20; 346(25):2013; author reply 2014. PMID: 12075069.
      View in: PubMed
    18. Chessler SD, Simonson WT, Sweet IR, Hammerle LP. Expression of the vesicular inhibitory amino acid transporter in pancreatic islet cells: distribution of the transporter within rat islets. Diabetes. 2002 Jun; 51(6):1763-71. PMID: 12031963.
      View in: PubMed
    19. Chessler SD, Lernmark A. Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues. J Biol Chem. 2000 Feb 18; 275(7):5188-92. PMID: 10671565.
      View in: PubMed
    20. McNeely MJ, Boyko EJ, Weigle DS, Shofer JB, Chessler SD, Leonnetti DL, Fujimoto WY. Association between baseline plasma leptin levels and subsequent development of diabetes in Japanese Americans. Diabetes Care. 1999 Jan; 22(1):65-70. PMID: 10333905.
      View in: PubMed
    21. Chessler SD, Fujimoto WY, Shofer JB, Boyko EJ, Weigle DS. Increased plasma leptin levels are associated with fat accumulation in Japanese Americans. Diabetes. 1998 Feb; 47(2):239-43. PMID: 9519719.
      View in: PubMed
    22. Lamandé SR, Chessler SD, Golub SB, Byers PH, Chan D, Cole WG, Sillence DO, Bateman JF. Endoplasmic reticulum-mediated quality control of type I collagen production by cells from osteogenesis imperfecta patients with mutations in the pro alpha 1 (I) chain carboxyl-terminal propeptide which impair subunit assembly. J Biol Chem. 1995 Apr 14; 270(15):8642-9. PMID: 7721766.
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    23. Chessler SD, Wallis GA, Byers PH. Mutations in the carboxyl-terminal propeptide of the pro alpha 1(I) chain of type I collagen result in defective chain association and produce lethal osteogenesis imperfecta. J Biol Chem. 1993 Aug 25; 268(24):18218-25. PMID: 8349697.
      View in: PubMed
    24. Chessler SD, Byers PH. BiP binds type I procollagen pro alpha chains with mutations in the carboxyl-terminal propeptide synthesized by cells from patients with osteogenesis imperfecta. J Biol Chem. 1993 Aug 25; 268(24):18226-33. PMID: 8349698.
      View in: PubMed
    25. Chessler SD, Byers PH. Defective folding and stable association with protein disulfide isomerase/prolyl hydroxylase of type I procollagen with a deletion in the pro alpha 2(I) chain that preserves the Gly-X-Y repeat pattern. J Biol Chem. 1992 Apr 15; 267(11):7751-7. PMID: 1339453.
      View in: PubMed
    26. Chessler S, Goldberg SM, Wasserstein AH. Group practice retains personal touch. Dent Surv. 1975 Oct; 51(10):87, 90-1. PMID: 1073142.
      View in: PubMed
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