Robert E Steele

Title(s)Professor, Biological Chemistry
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-7341, 9367
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    Tools for genetic and genomic studies in Hydra
    NIH R24GM080537Apr 1, 2008 - Mar 31, 2013
    Role: Principal Investigator
    NIH R01RR009755Aug 15, 1993 - Aug 14, 1997
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. SPIM-Flow: An Integrated Light Sheet and Microfluidics Platform for Hydrodynamic Studies of Hydra. Biology (Basel). 2023 Jan 11; 12(1). Hedde PN, Le BT, Gomez EL, Duong L, Steele RE, Ahrar S. PMID: 36671808.
      View in: PubMed   Mentions:
    2. Vitellogenesis: The evolutionary origins of nutrient uptake in animals. Curr Biol. 2022 Nov 07; 32(21):R1233-R1235. Steele RE. PMID: 36347232.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. The Hippo pathway regulates axis formation and morphogenesis in Hydra. Proc Natl Acad Sci U S A. 2022 07 19; 119(29):e2203257119. Brooun M, Salvenmoser W, Dana C, Sudol M, Steele R, Hobmayer B, McNeill H. PMID: 35858299; PMCID: PMC9304002.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Traffic light Hydra allows for simultaneous in vivo imaging of all three cell lineages. Dev Biol. 2022 08; 488:74-80. Wang R, DuBuc TQ, Steele RE, Collins ES. PMID: 35577031.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Deeply conserved synteny and the evolution of metazoan chromosomes. Sci Adv. 2022 Feb 04; 8(5):eabi5884. Simakov O, Bredeson J, Berkoff K, Marletaz F, Mitros T, Schultz DT, O'Connell BL, Dear P, Martinez DE, Steele RE, Green RE, David CN, Rokhsar DS. PMID: 35108053; PMCID: PMC8809688.
      View in: PubMed   Mentions: 16     Fields:    
    6. A qualitative evaluation of the impact of a training programme on colorectal cancer risk reduction for Specialist Screening Practitioners on health promotion, knowledge and practice. Eur J Cancer Care (Engl). 2021 Jan; 30(1):e13350. Anderson A, Barnett K, Bhagat M, Steele R. PMID: 33119181; PMCID: PMC7900982.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    7. Gene Editing: A Tool for Tackling Cephalopod Biology. Curr Biol. 2020 09 07; 30(17):R986-R988. Steele RE. PMID: 32898496.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    8. Wnt signaling determines body axis polarity in regenerating Hydra tissue fragments. Dev Biol. 2020 11 01; 467(1-2):88-94. Wang R, Steele RE, Collins ES. PMID: 32871156.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    9. Ancestral roles of atypical cadherins in planar cell polarity. Proc Natl Acad Sci U S A. 2020 08 11; 117(32):19310-19320. Brooun M, Klimovich A, Bashkurov M, Pearson BJ, Steele RE, McNeill H. PMID: 32727892; PMCID: PMC7430989.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    10. Expansion of a single transposable element family is associated with genome-size increase and radiation in the genus Hydra. Proc Natl Acad Sci U S A. 2019 11 12; 116(46):22915-22917. Wong WY, Simakov O, Bridge DM, Cartwright P, Bellantuono AJ, Kuhn A, Holstein TW, David CN, Steele RE, Martínez DE. PMID: 31659034; PMCID: PMC6859323.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    11. Reproductive Bet-Hedging and Existence in Vernal Pools as Components of Hydra Life History. Biol Bull. 2019 10; 237(2):111-118. Steele RE, Updegrove MD, Kirolos SA, Mowery L, Martínez DE, Bryant PJ. PMID: 31714853.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    12. The genome of the jellyfish Aurelia and the evolution of animal complexity. Nat Ecol Evol. 2019 01; 3(1):96-104. Gold DA, Katsuki T, Li Y, Yan X, Regulski M, Ibberson D, Holstein T, Steele RE, Jacobs DK, Greenspan RJ. PMID: 30510179.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    13. Physical Mechanisms Driving Cell Sorting in Hydra. Biophys J. 2017 Dec 19; 113(12):2827-2841. Cochet-Escartin O, Locke TT, Shi WH, Steele RE, Collins ES. PMID: 29262375; PMCID: PMC5771031.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    14. Hydroidfest 2016: celebrating a renaissance in hydrozoan research. Evodevo. 2017; 8:7. Dupre C, Grasis JA, Steele RE, Schnitzler CE, Juliano CE. PMID: 31504077; PMCID: PMC5408429.
      View in: PubMed   Mentions:
    15. Dynamics of Mouth Opening in Hydra. Biophys J. 2016 Mar 08; 110(5):1191-201. Carter JA, Hyland C, Steele RE, Collins EM. PMID: 26958895; PMCID: PMC4788721.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    16. A small molecule screen identifies a novel compound that induces a homeotic transformation in Hydra. Development. 2015 Jun 01; 142(11):2081. Glauber KM, Dana CE, Park SS, Colby DA, Noro Y, Fujisawa T, Chamberlin AR, Steele RE. PMID: 26015540; PMCID: PMC4460743.
      View in: PubMed   Mentions: 4     Fields:    
    17. Generation of transgenic Hydra by embryo microinjection. J Vis Exp. 2014 Sep 11; (91):51888. Juliano CE, Lin H, Steele RE. PMID: 25285460; PMCID: PMC4828061.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    18. PIWI proteins and PIWI-interacting RNAs function in Hydra somatic stem cells. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):337-42. Juliano CE, Reich A, Liu N, Götzfried J, Zhong M, Uman S, Reenan RA, Wessel GM, Steele RE, Lin H. PMID: 24367095; PMCID: PMC3890812.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    19. A unique covalent bond in basement membrane is a primordial innovation for tissue evolution. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):331-6. Fidler AL, Vanacore RM, Chetyrkin SV, Pedchenko VK, Bhave G, Yin VP, Stothers CL, Rose KL, McDonald WH, Clark TA, Borza DB, Steele RE, Ivy MT, Aspirnauts, Hudson JK, Hudson BG. PMID: 24344311; PMCID: PMC3890831.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    20. A small molecule screen identifies a novel compound that induces a homeotic transformation in Hydra. Development. 2013 Dec; 140(23):4788-96. Glauber KM, Dana CE, Park SS, Colby DA, Noro Y, Fujisawa T, Chamberlin AR, Steele RE. PMID: 24255098; PMCID: PMC3833435.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    21. Incorporation of a horizontally transferred gene into an operon during cnidarian evolution. PLoS One. 2012; 7(2):e31643. Dana CE, Glauber KM, Chan TA, Bridge DM, Steele RE. PMID: 22328943; PMCID: PMC3273482.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    22. The Hydra genome: insights, puzzles and opportunities for developmental biologists. Int J Dev Biol. 2012; 56(6-8):535-42. Steele RE. PMID: 22689362.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    23. Evolutionary crossroads in developmental biology: Cnidaria. Development. 2011 Apr; 138(8):1447-58. Technau U, Steele RE. PMID: 21389047; PMCID: PMC3062418.
      View in: PubMed   Mentions: 93     Fields:    Translation:Animals
    24. Hydra. Curr Biol. 2010 Nov 23; 20(22):R964-5. Glauber KM, Dana CE, Steele RE. PMID: 21093784.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    25. A genomic view of 500 million years of cnidarian evolution. Trends Genet. 2011 Jan; 27(1):7-13. Steele RE, David CN, Technau U. PMID: 21047698; PMCID: PMC3058326.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    26. FoxO and stress responses in the cnidarian Hydra vulgaris. PLoS One. 2010 Jul 21; 5(7):e11686. Bridge D, Theofiles AG, Holler RL, Marcinkevicius E, Steele RE, Martínez DE. PMID: 20657733; PMCID: PMC2908143.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    27. The dynamic genome of Hydra. Nature. 2010 Mar 25; 464(7288):592-6. Chapman JA, Kirkness EF, Simakov O, Hampson SE, Mitros T, Weinmaier T, Rattei T, Balasubramanian PG, Borman J, Busam D, Disbennett K, Pfannkoch C, Sumin N, Sutton GG, Viswanathan LD, Walenz B, Goodstein DM, Hellsten U, Kawashima T, Prochnik SE, Putnam NH, Shu S, Blumberg B, Dana CE, Gee L, Kibler DF, Law L, Lindgens D, Martinez DE, Peng J, Wigge PA, Bertulat B, Guder C, Nakamura Y, Ozbek S, Watanabe H, Khalturin K, Hemmrich G, Franke A, Augustin R, Fraune S, Hayakawa E, Hayakawa S, Hirose M, Hwang JS, Ikeo K, Nishimiya-Fujisawa C, Ogura A, Takahashi T, Steinmetz PR, Zhang X, Aufschnaiter R, Eder MK, Gorny AK, Salvenmoser W, Heimberg AM, Wheeler BM, Peterson KJ, Böttger A, Tischler P, Wolf A, Gojobori T, Remington KA, Strausberg RL, Venter JC, Technau U, Hobmayer B, Bosch TC, Holstein TW, Fujisawa T, Bode HR, David CN, Rokhsar DS, Steele RE. PMID: 20228792; PMCID: PMC4479502.
      View in: PubMed   Mentions: 350     Fields:    Translation:AnimalsCells
    28. Evolutionary history of the HAP2/GCS1 gene and sexual reproduction in metazoans. PLoS One. 2009 Nov 03; 4(11):e7680. Steele RE, Dana CE. PMID: 19888453; PMCID: PMC2766252.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    29. Evolutionary differences in glycosaminoglycan fine structure detected by quantitative glycan reductive isotope labeling. J Biol Chem. 2008 Nov 28; 283(48):33674-84. Lawrence R, Olson SK, Steele RE, Wang L, Warrior R, Cummings RD, Esko JD. PMID: 18818196; PMCID: PMC2586254.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    30. The conserved plant sterility gene HAP2 functions after attachment of fusogenic membranes in Chlamydomonas and Plasmodium gametes. Genes Dev. 2008 Apr 15; 22(8):1051-68. Liu Y, Tewari R, Ning J, Blagborough AM, Garbom S, Pei J, Grishin NV, Steele RE, Sinden RE, Snell WJ, Billker O. PMID: 18367645; PMCID: PMC2335326.
      View in: PubMed   Mentions: 144     Fields:    Translation:AnimalsCells
    31. Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization. Science. 2007 Jul 06; 317(5834):86-94. Putnam NH, Srivastava M, Hellsten U, Dirks B, Chapman J, Salamov A, Terry A, Shapiro H, Lindquist E, Kapitonov VV, Jurka J, Genikhovich G, Grigoriev IV, Lucas SM, Steele RE, Finnerty JR, Technau U, Martindale MQ, Rokhsar DS. PMID: 17615350.
      View in: PubMed   Mentions: 678     Fields:    Translation:HumansAnimalsCells
    32. Trembley's polyps go transgenic. Proc Natl Acad Sci U S A. 2006 Apr 25; 103(17):6415-6. Steele RE. PMID: 16618934; PMCID: PMC1458899.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    33. Introduction to the symposium. Integr Comp Biol. 2005 Aug; 45(4):583-4. Blackstone NW, Steele RE. PMID: 21676804.
      View in: PubMed   Mentions:    Fields:    
    34. Genomics of Basal metazoans. Integr Comp Biol. 2005 Aug; 45(4):639-48. Steele RE. PMID: 21676811.
      View in: PubMed   Mentions: 3     Fields:    
    35. Probable horizontal transfer of a gene between a protist and a cnidarian. Curr Biol. 2004 Apr 20; 14(8):R298-9. Steele RE, Hampson SE, Stover NA, Kibler DF, Bode HR. PMID: 15084296.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    36. Arrested apoptosis of nurse cells during Hydra oogenesis and embryogenesis. Dev Biol. 2003 Aug 01; 260(1):191-206. Technau U, Miller MA, Bridge D, Steele RE. PMID: 12885564.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    37. Developmental signaling in Hydra: what does it take to build a "simple" animal? Dev Biol. 2002 Aug 15; 248(2):199-219. Steele RE. PMID: 12167399.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    38. Distinct functional role of Hepatitis C virus core protein on NF-kappaB regulation is linked to genomic variation. Virus Res. 2002 Jul; 87(1):21-9. Ray RB, Steele R, Basu A, Meyer K, Majumder M, Ghosh AK, Ray R. PMID: 12135786.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    39. Trans-spliced leader addition to mRNAs in a cnidarian. Proc Natl Acad Sci U S A. 2001 May 08; 98(10):5693-8. Stover NA, Steele RE. PMID: 11331766; PMCID: PMC33275.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    40. Lemon encodes an unusual receptor protein-tyrosine kinase expressed during gametogenesis in Hydra. Dev Biol. 2000 Aug 15; 224(2):286-98. Miller MA, Steele RE. PMID: 10926767.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    41. Oocyte development in Hydra involves selection from competent precursor cells. Dev Biol. 2000 Aug 15; 224(2):326-38. Miller MA, Technau U, Smith KM, Steele RE. PMID: 10926770.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    42. The Src/Csk regulatory circuit arose early in metazoan evolution. Oncogene. 2000 Aug 10; 19(34):3925-30. Miller MA, Malik IA, Shenk MA, Steele RE. PMID: 10951585.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    43. Expression of a novel receptor tyrosine kinase gene and a paired-like homeobox gene provides evidence of differences in patterning at the oral and aboral ends of hydra. Dev Biol. 2000 Apr 15; 220(2):253-62. Bridge DM, Stover NA, Steele RE. PMID: 10753514.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    44. Sweet Tooth, a novel receptor protein-tyrosine kinase with C-type lectin-like extracellular domains. J Biol Chem. 2000 Apr 07; 275(14):10323-30. Reidling JC, Miller MA, Steele RE. PMID: 10744720.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    45. Appearance and disappearance of Syk family protein-tyrosine kinase genes during metazoan evolution. Gene. 1999 Oct 18; 239(1):91-7. Steele RE, Stover NA, Sakaguchi M. PMID: 10571038.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    46. Budhead, a fork head/HNF-3 homologue, is expressed during axis formation and head specification in hydra. Dev Biol. 1997 Dec 15; 192(2):523-36. Martinez DE, Dirksen ML, Bode PM, Jamrich M, Steele RE, Bode HR. PMID: 9441686.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    47. Response to insulin and the expression pattern of a gene encoding an insulin receptor homologue suggest a role for an insulin-like molecule in regulating growth and patterning in Hydra. Dev Genes Evol. 1996 Nov; 206(4):247-59. Steele RE, Lieu P, Mai NH, Shenk MA, Sarras MP. PMID: 24173564.
      View in: PubMed   Mentions: 10     Fields:    
    48. Single step purification of biologically active recombinant rat basic fibroblast growth factor by immobilized metal affinity chromatography. Biochim Biophys Acta. 1995 Jul 03; 1250(1):29-34. Kroiher M, Raffioni S, Steele RE. PMID: 7612650.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    49. Identification of a gene encoding a novel protein-tyrosine kinase containing SH2 domains and ankyrin-like repeats. Oncogene. 1994 Apr; 9(4):1253-9. Chan TA, Chu CA, Rauen KA, Kroiher M, Tatarewicz SM, Steele RE. PMID: 8134129.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    50. A molecular snapshot of the metazoan 'Eve'. Trends Biochem Sci. 1993 Dec; 18(12):459-63. Shenk MA, Steele RE. PMID: 7906442.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    51. Expression of Cnox-2, a HOM/HOX gene, is suppressed during head formation in hydra. Dev Biol. 1993 Nov; 160(1):108-18. Shenk MA, Gee L, Steele RE, Bode HR. PMID: 7901102.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    52. Alternative splicing of a neural-specific Src mRNA (Src+) is a rapid and protein synthesis-independent response to neural induction in Xenopus laevis. Dev Biol. 1993 Aug; 158(2):487-95. Collett JW, Steele RE. PMID: 8344464.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    53. Expression of Cnox-2, a HOM/HOX homeobox gene in hydra, is correlated with axial pattern formation. Development. 1993 Feb; 117(2):657-67. Shenk MA, Bode HR, Steele RE. PMID: 8101168.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    54. Biochemical and cytological changes associated with expression of deregulated pp60src in Xenopus oocytes. Mol Cell Biol. 1992 Dec; 12(12):5485-98. Unger TF, Steele RE. PMID: 1280323; PMCID: PMC360486.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    55. Structural organization of a src gene from Xenopus laevis. Oncogene. 1992 Nov; 7(11):2345-50. Ghosn CR, Ral BB, Winokur ST, Unger TF, Steele RE. PMID: 1437158.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    56. Identification and developmental expression of Src+ mRNAs in Xenopus laevis. Dev Biol. 1992 Jul; 152(1):194-8. Collett JW, Steele RE. PMID: 1378412.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    57. A transcription factor (?) joins the SH2 crowd. Trends Biochem Sci. 1992 Jun; 17(6):205-6. Steele RE. PMID: 1502720.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    58. Factor hunting made easier. Trends Biochem Sci. 1991 Apr; 16(4):125-6. Steele RE. PMID: 1652170.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    59. Protein-tyrosine phosphorylation: a glimmer of light in the darkness. Trends Biochem Sci. 1990 Apr; 15(4):124-6. Steele RE. PMID: 1692646.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    60. Structure and expression of fyn genes in Xenopus laevis. Oncogene. 1990 Mar; 5(3):369-76. Steele RE, Deng JC, Ghosn CR, Fero JB. PMID: 2179818.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    61. Structure and expression of STK, a src-related gene in the simple metazoan Hydra attenuata. Mol Cell Biol. 1989 Oct; 9(10):4141-51. Bosch TC, Unger TF, Fisher DA, Steele RE. PMID: 2479820; PMCID: PMC362492.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    62. The two Xenopus laevis SRC genes are co-expressed and each produces functional pp60src. J Biol Chem. 1989 Jun 25; 264(18):10649-53. Steele RE, Unger TF, Mardis MJ, Fero JB. PMID: 2499582.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    63. The yes proto-oncogene is present in amphibians and contributes to the maternal RNA pool in the oocyte. Oncogene Res. 1989; 4(3):223-33. Steele RE, Irwin MY, Knudsen CL, Collett JW, Fero JB. PMID: 2472592.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    64. Thermotolerance and synthesis of heat shock proteins: these responses are present in Hydra attenuata but absent in Hydra oligactis. Proc Natl Acad Sci U S A. 1988 Nov; 85(21):7927-31. Bosch TC, Krylow SM, Bode HR, Steele RE. PMID: 3186697; PMCID: PMC282326.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
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