Ramon Jose Ayon

Title(s)Assistant Professor In Residence, Medicine
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
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    1. Deletion of RSK2 kinase alleviates age-dependent hypertension. bioRxiv. 2025 Mar 14. Ayon R, Wang YT, Kalra J, Jin L, Chen YL, Polanowska-Grabowska R, Sonkusare SK, Christie CK, Small EM, Le TH, Somlyo AV. PMID: 40161735; PMCID: PMC11952561.
      View in: PubMed   Mentions:
    2. Editorial: Calcium regulation and Mechano-transduction in vascular diseases: obligatory role of transient receptor potential and Piezo channels. Front Physiol. 2024; 15:1375432. Ayon RJ, Kuppusamy M, Ceolotto G, Chen YL. PMID: 38482192; PMCID: PMC10933086.
      View in: PubMed   Mentions:
    3. p90RSK2, a new MLCK mediates contractility in myosin light chain kinase null smooth muscle. Front Physiol. 2023; 14:1228488. Kalra J, Artamonov M, Wang H, Franke A, Markowska Z, Jin L, Derewenda ZS, Ayon RJ, Somlyo A. PMID: 37781225; PMCID: PMC10533999.
      View in: PubMed   Mentions:
    4. Revisiting the Role of KCNA5 in Pulmonary Arterial Hypertension. Am J Respir Cell Mol Biol. 2023 08; 69(2):123-125. Ayon RJ, Yuan JX. PMID: 37201951; PMCID: PMC10399140.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. p90RSK2, a new MLCK, rescues contractility in myosin light chain kinase null smooth muscle. bioRxiv. 2023 May 22. Kalra J, Artamonov M, Wang H, Franke A, Markowska Z, Jin L, Derewenda ZS, Ayon R, Somlyo A. PMID: 37292593; PMCID: PMC10245941.
      View in: PubMed   Mentions:
    6. Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension. Am J Physiol Cell Physiol. 2021 12 01; 321(6):C1010-C1027. Wang Z, Chen J, Babicheva A, Jain PP, Rodriguez M, Ayon RJ, Ravellette KS, Wu L, Balistrieri F, Tang H, Wu X, Zhao T, Black SM, Desai AA, Garcia JGN, Sun X, Shyy JY, Valdez-Jasso D, Thistlethwaite PA, Makino A, Wang J, Yuan JX. PMID: 34669509; PMCID: PMC8714987.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    7. Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes. Pulm Circ. 2020 Oct-Dec; 10(4):2045894020968531. Romanoski CE, Qi X, Sangam S, Vanderpool RR, Stearman RS, Conklin A, Gonzalez-Garay M, Rischard F, Ayon RJ, Wang J, Simonson T, Babicheva A, Shi Y, Tang H, Makino A, Kanthi Y, Geraci MW, Garcia JGN, Yuan JX, Desai AA. PMID: 33343881; PMCID: PMC7727059.
      View in: PubMed   Mentions: 15  
    8. Endothelial platelet-derived growth factor-mediated activation of smooth muscle platelet-derived growth factor receptors in pulmonary arterial hypertension. Pulm Circ. 2020 Jul-Sep; 10(3):2045894020948470. Wu K, Tang H, Lin R, Carr SG, Wang Z, Babicheva A, Ayon RJ, Jain PP, Xiong M, Rodriguez M, Rahimi S, Balistrieri F, Rahimi S, Valdez-Jasso D, Simonson TS, Desai AA, Garcia JGN, Shyy JY, Thistlethwaite PA, Wang J, Makino A, Yuan JX. PMID: 33294172; PMCID: PMC7707860.
      View in: PubMed   Mentions: 10  
    9. Notch enhances Ca2+ entry by activating calcium-sensing receptors and inhibiting voltage-gated K+ channels. Am J Physiol Cell Physiol. 2020 05 01; 318(5):C954-C968. Song S, Babicheva A, Zhao T, Ayon RJ, Rodriguez M, Rahimi S, Balistrieri F, Harrington A, Shyy JY, Thistlethwaite PA, Makino A, Yuan JX. PMID: 32186932; PMCID: PMC7294324.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    10. MicroRNA-mediated downregulation of K+ channels in pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2020 01 01; 318(1):L10-L26. Babicheva A, Ayon RJ, Zhao T, Ek Vitorin JF, Pohl NM, Yamamura A, Yamamura H, Quinton BA, Ba M, Wu L, Ravellette KS, Rahimi S, Balistrieri F, Harrington A, Vanderpool RR, Thistlethwaite PA, Makino A, Yuan JX. PMID: 31553627; PMCID: PMC6985878.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    11. Molecular mechanism of TMEM16A regulation: role of CaMKII and PP1/PP2A. Am J Physiol Cell Physiol. 2019 12 01; 317(6):C1093-C1106. Ayon RJ, Hawn MB, Aoun J, Wiwchar M, Forrest AS, Cunningham F, Singer CA, Valencik ML, Greenwood IA, Leblanc N. PMID: 31461344; PMCID: PMC6957382.
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    12. PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension. Proc Natl Acad Sci U S A. 2019 07 02; 116(27):13394-13403. Cao Y, Zhang X, Wang L, Yang Q, Ma Q, Xu J, Wang J, Kovacs L, Ayon RJ, Liu Z, Zhang M, Zhou Y, Zeng X, Xu Y, Wang Y, Fulton DJ, Weintraub NL, Lucas R, Dong Z, Yuan JX, Sullivan JC, Meadows L, Barman SA, Wu C, Quan J, Hong M, Su Y, Huo Y. PMID: 31213542; PMCID: PMC6613097.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    13. Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension. JACC Basic Transl Sci. 2018 Dec; 3(6):744-762. Tang H, Wu K, Wang J, Vinjamuri S, Gu Y, Song S, Wang Z, Zhang Q, Balistrieri A, Ayon RJ, Rischard F, Vanderpool R, Chen J, Zhou G, Desai AA, Black SM, Garcia JGN, Yuan JX, Makino A. PMID: 30623134; PMCID: PMC6314964.
      View in: PubMed   Mentions: 35  
    14. Divergent changes of p53 in pulmonary arterial endothelial and smooth muscle cells involved in the development of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2019 01 01; 316(1):L216-L228. Wang Z, Yang K, Zheng Q, Zhang C, Tang H, Babicheva A, Jiang Q, Li M, Chen Y, Carr SG, Wu K, Zhang Q, Balistrieri A, Wang C, Song S, Ayon RJ, Desai AA, Black SM, Garcia JGN, Makino A, Yuan JX, Lu W, Wang J. PMID: 30358436; PMCID: PMC6383500.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    15. STIM2 (Stromal Interaction Molecule 2)-Mediated Increase in Resting Cytosolic Free Ca2+ Concentration Stimulates PASMC Proliferation in Pulmonary Arterial Hypertension. Hypertension. 2018 03; 71(3):518-529. Song S, Carr SG, McDermott KM, Rodriguez M, Babicheva A, Balistrieri A, Ayon RJ, Wang J, Makino A, Yuan JX. PMID: 29358461; PMCID: PMC5955710.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    16. Hypoxia selectively upregulates cation channels and increases cytosolic [Ca2+] in pulmonary, but not coronary, arterial smooth muscle cells. Am J Physiol Cell Physiol. 2018 04 01; 314(4):C504-C517. He X, Song S, Ayon RJ, Balisterieri A, Black SM, Makino A, Wier WG, Zang WJ, Yuan JX. PMID: 29351410; PMCID: PMC5966788.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    17. Endothelial dysfunction in pulmonary arterial hypertension: an evolving landscape (2017 Grover Conference Series). Pulm Circ. 2018 Jan-Mar; 8(1):2045893217752912. Ranchoux B, Harvey LD, Ayon RJ, Babicheva A, Bonnet S, Chan SY, Yuan JX, Perez VJ. PMID: 29283043; PMCID: PMC5798691.
      View in: PubMed   Mentions: 72  
    18. Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition. Am J Physiol Lung Cell Mol Physiol. 2018 02 01; 314(2):L256-L275. Tang H, Babicheva A, McDermott KM, Gu Y, Ayon RJ, Song S, Wang Z, Gupta A, Zhou T, Sun X, Dash S, Wang Z, Balistrieri A, Zheng Q, Cordery AG, Desai AA, Rischard F, Khalpey Z, Wang J, Black SM, Garcia JGN, Makino A, Yuan JX. PMID: 29074488; PMCID: PMC5866501.
      View in: PubMed   Mentions: 124     Fields:    Translation:AnimalsCells
    19. Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension. Br J Pharmacol. 2017 Nov; 174(22):4155-4172. Wu K, Zhang Q, Wu X, Lu W, Tang H, Liang Z, Gu Y, Song S, Ayon RJ, Wang Z, McDermott KM, Balistrieri A, Wang C, Black SM, Garcia JGN, Makino A, Yuan JX, Wang J. PMID: 28849593; PMCID: PMC5659991.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    20. Capsaicin-induced Ca2+ signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH. Am J Physiol Lung Cell Mol Physiol. 2017 03 01; 312(3):L309-L325. Song S, Ayon RJ, Yamamura A, Yamamura H, Dash S, Babicheva A, Tang H, Sun X, Cordery AG, Khalpey Z, Black SM, Desai AA, Rischard F, McDermott KM, Garcia JG, Makino A, Yuan JX. PMID: 27979859; PMCID: PMC5374303.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    21. Calcium-Sensing Receptor Regulates Cytosolic [Ca 2+ ] and Plays a Major Role in the Development of Pulmonary Hypertension. Front Physiol. 2016; 7:517. Smith KA, Ayon RJ, Tang H, Makino A, Yuan JX. PMID: 27867361; PMCID: PMC5095111.
      View in: PubMed   Mentions: 35  
    22. Ryanodine receptor-2: a necessity for gating store-operated Ca2+ channels. Cardiovasc Res. 2016 07 01; 111(1):13-5. Song S, Ayon RJ, Yuan JX. PMID: 27229459.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    23. Pathogenic role of calcium-sensing receptors in the development and progression of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2016 05 01; 310(9):L846-59. Tang H, Yamamura A, Yamamura H, Song S, Fraidenburg DR, Chen J, Gu Y, Pohl NM, Zhou T, Jiménez-Pérez L, Ayon RJ, Desai AA, Goltzman D, Rischard F, Khalpey Z, Black SM, Garcia JG, Makino A, Yuan JX. PMID: 26968768; PMCID: PMC4867349.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    24. Gasping for answers. Focus on "Calpain activation by ROS mediates human ether-a-go-go-related gene protein degradation by intermittent hypoxia". Am J Physiol Cell Physiol. 2016 Mar 15; 310(6):C432-3. Ayon RJ, Tang H, Yuan JX. PMID: 26843530; PMCID: PMC4796283.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    25. SGLT inhibitors attenuate NO-dependent vascular relaxation in the pulmonary artery but not in the coronary artery. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 01; 309(9):L1027-36. Han Y, Cho YE, Ayon R, Guo R, Youssef KD, Pan M, Dai A, Yuan JX, Makino A. PMID: 26361875; PMCID: PMC4628985.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimals
    26. Molecular and functional significance of Ca(2+)-activated Cl(-) channels in pulmonary arterial smooth muscle. Pulm Circ. 2015 Jun; 5(2):244-68. Leblanc N, Forrest AS, Ayon RJ, Wiwchar M, Angermann JE, Pritchard HA, Singer CA, Valencik ML, Britton F, Greenwood IA. PMID: 26064450; PMCID: PMC4449236.
      View in: PubMed   Mentions:
    27. New insights into the pathology of pulmonary hypertension: implication of the miR-210/ISCU1/2/Fe-S axis. EMBO Mol Med. 2015 Jun; 7(6):689-91. Tang H, Ayon RJ, Yuan JX. PMID: 25851536; PMCID: PMC4459811.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    28. Flow shear stress enhances intracellular Ca2+ signaling in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension. Am J Physiol Cell Physiol. 2014 Aug 15; 307(4):C373-83. Song S, Yamamura A, Yamamura H, Ayon RJ, Smith KA, Tang H, Makino A, Yuan JX. PMID: 24920677; PMCID: PMC4137136.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    29. Mutant hERG channel traffic jam. Focus on "Pharmacological correction of long QT-linked mutations in KCNH2 (hERG) increases the trafficking of Kv11.1 channels stored in the transitional endoplasmic reticulum". Am J Physiol Cell Physiol. 2013 Nov 01; 305(9):C916-8. Ayon RJ, Fernandez RA, Yuan JX. PMID: 23986200.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    30. Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca2+ channel activity in pulmonary artery by upregulating Cav1.2 and Cav3.2. Am J Physiol Lung Cell Mol Physiol. 2013 Jul 15; 305(2):L154-64. Wan J, Yamamura A, Zimnicka AM, Voiriot G, Smith KA, Tang H, Ayon RJ, Choudhury MS, Ko EA, Wang J, Wang C, Makino A, Yuan JX. PMID: 23686856; PMCID: PMC3726947.
      View in: PubMed   Mentions: 52     Fields:    
    31. Functional characterization of voltage-dependent Ca(2+) channels in mouse pulmonary arterial smooth muscle cells: divergent effect of ROS. Am J Physiol Cell Physiol. 2013 Jun 01; 304(11):C1042-52. Ko EA, Wan J, Yamamura A, Zimnicka AM, Yamamura H, Yoo HY, Tang H, Smith KA, Sundivakkam PC, Zeifman A, Ayon RJ, Makino A, Yuan JX. PMID: 23426966; PMCID: PMC3677177.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    32. Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension. Am J Physiol Cell Physiol. 2012 Dec 15; 303(12):C1229-43. Forrest AS, Joyce TC, Huebner ML, Ayon RJ, Wiwchar M, Joyce J, Freitas N, Davis AJ, Ye L, Duan DD, Singer CA, Valencik ML, Greenwood IA, Leblanc N. PMID: 23034390; PMCID: PMC3532492.
      View in: PubMed   Mentions:
    33. Phosphorylation alters the pharmacology of Ca(2+)-activated Cl channels in rabbit pulmonary arterial smooth muscle cells. Br J Pharmacol. 2009 Nov; 158(5):1356-65. Wiwchar M, Ayon R, Greenwood IA, Leblanc N. PMID: 19785656; PMCID: PMC2782345.
      View in: PubMed   Mentions:
    34. Complex phosphatase regulation of Ca2+-activated Cl- currents in pulmonary arterial smooth muscle cells. J Biol Chem. 2009 Nov 20; 284(47):32507-21. Ayon R, Sones W, Forrest AS, Wiwchar M, Valencik ML, Sanguinetti AR, Perrino BA, Greenwood IA, Leblanc N. PMID: 19767392; PMCID: PMC2781665.
      View in: PubMed   Mentions:
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