Kevin R. Thornton

Title(s)Associate Professor, Ecology & Evolutionary Biology
SchoolSchool of Biological Sciences
Address5221 McGaugh Hall
Zot 2525
Irvine CA 92697
Phone(949) 824-0614
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    Collapse Research 
    Collapse Research Activities and Funding
    Population genomics of polygenic adaptation
    NIH R01GM115564Sep 16, 2015 - May 31, 2020
    Role: Principal Investigator
    Population genetics of gene duplications and copy-number variants in the Drosophi
    NIH R01GM085183Aug 1, 2009 - Oct 31, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Demes: a standard format for demographic models. Genetics. 2022 11 01; 222(3). Gower G, Ragsdale AP, Bisschop G, Gutenkunst RN, Hartfield M, Noskova E, Schiffels S, Struck TJ, Kelleher J, Thornton KR. PMID: 36173327; PMCID: PMC9630982.
      View in: PubMed   Mentions: 6     Fields:    
    2. Efficient ancestry and mutation simulation with msprime 1.0. Genetics. 2022 03 03; 220(3). Baumdicker F, Bisschop G, Goldstein D, Gower G, Ragsdale AP, Tsambos G, Zhu S, Eldon B, Ellerman EC, Galloway JG, Gladstein AL, Gorjanc G, Guo B, Jeffery B, Kretzschumar WW, Lohse K, Matschiner M, Nelson D, Pope NS, Quinto-Cortés CD, Rodrigues MF, Saunack K, Sellinger T, Thornton K, van Kemenade H, Wohns AW, Wong Y, Gravel S, Kern AD, Koskela J, Ralph PL, Kelleher J. PMID: 34897427; PMCID: PMC9176297.
      View in: PubMed   Mentions: 55     Fields:    
    3. Efficiently Summarizing Relationships in Large Samples: A General Duality Between Statistics of Genealogies and Genomes. Genetics. 2020 07; 215(3):779-797. Ralph P, Thornton K, Kelleher J. PMID: 32357960; PMCID: PMC7337078.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    4. Polygenic Adaptation to an Environmental Shift: Temporal Dynamics of Variation Under Gaussian Stabilizing Selection and Additive Effects on a Single Trait. Genetics. 2019 12; 213(4):1513-1530. Thornton KR. PMID: 31653678; PMCID: PMC6893385.
      View in: PubMed   Mentions: 22     Fields:    
    5. Genetic architecture and selective sweeps after polygenic adaptation to distant trait optima. PLoS Genet. 2018 11; 14(11):e1007794. Stetter MG, Thornton K, Ross-Ibarra J. PMID: 30452452; PMCID: PMC6277123.
      View in: PubMed   Mentions: 25     Fields:    
    6. Efficient pedigree recording for fast population genetics simulation. PLoS Comput Biol. 2018 11; 14(11):e1006581. Kelleher J, Thornton KR, Ashander J, Ralph PL. PMID: 30383757; PMCID: PMC6233923.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    7. Evidence of directional and stabilizing selection in contemporary humans. Proc Natl Acad Sci U S A. 2018 01 02; 115(1):151-156. Sanjak JS, Sidorenko J, Robinson MR, Thornton KR, Visscher PM. PMID: 29255044; PMCID: PMC5776788.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    8. Tandem duplications lead to novel expression patterns through exon shuffling in Drosophila yakuba. PLoS Genet. 2017 May; 13(5):e1006795. Rogers RL, Shao L, Thornton KR. PMID: 28531189; PMCID: PMC5460883.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    9. A Model of Compound Heterozygous, Loss-of-Function Alleles Is Broadly Consistent with Observations from Complex-Disease GWAS Datasets. PLoS Genet. 2017 01; 13(1):e1006573. Sanjak JS, Long AD, Thornton KR. PMID: 28103232; PMCID: PMC5289629.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    10. Efficient Software for Multi-marker, Region-Based Analysis of GWAS Data. G3 (Bethesda). 2016 04 07; 6(4):1023-30. Sanjak JS, Long AD, Thornton KR. PMID: 26865700; PMCID: PMC4825638.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Tandem Duplications and the Limits of Natural Selection in Drosophila yakuba and Drosophila simulans. PLoS One. 2015; 10(7):e0132184. Rogers RL, Cridland JM, Shao L, Hu TT, Andolfatto P, Thornton KR. PMID: 26176952; PMCID: PMC4503668.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    12. Gene expression variation in Drosophila melanogaster due to rare transposable element insertion alleles of large effect. Genetics. 2015 Jan; 199(1):85-93. Cridland JM, Thornton KR, Long AD. PMID: 25335504; PMCID: PMC4286695.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    13. Revised annotations, sex-biased expression, and lineage-specific genes in the Drosophila melanogaster group. G3 (Bethesda). 2014 Oct 01; 4(12):2345-51. Rogers RL, Shao L, Sanjak JS, Andolfatto P, Thornton KR. PMID: 25273863; PMCID: PMC4267930.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    14. A C++ template library for efficient forward-time population genetic simulation of large populations. Genetics. 2014 Sep; 198(1):157-66. Thornton KR. PMID: 24950894; PMCID: PMC4174927.
      View in: PubMed   Mentions: 35     Fields:    
    15. Landscape of standing variation for tandem duplications in Drosophila yakuba and Drosophila simulans. Mol Biol Evol. 2014 Jul; 31(7):1750-66. Rogers RL, Cridland JM, Shao L, Hu TT, Andolfatto P, Thornton KR. PMID: 24710518; PMCID: PMC4069613.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    16. The power to detect quantitative trait loci using resequenced, experimentally evolved populations of diploid, sexual organisms. Mol Biol Evol. 2014 Apr; 31(4):1040-55. Baldwin-Brown JG, Long AD, Thornton KR. PMID: 24441104; PMCID: PMC3969567.
      View in: PubMed   Mentions: 45     Fields:    Translation:Animals
    17. Abundance and distribution of transposable elements in two Drosophila QTL mapping resources. Mol Biol Evol. 2013 Oct; 30(10):2311-27. Cridland JM, Macdonald SJ, Long AD, Thornton KR. PMID: 23883524; PMCID: PMC3773372.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    18. Properties and modeling of GWAS when complex disease risk is due to non-complementing, deleterious mutations in genes of large effect. PLoS Genet. 2013; 9(2):e1003258. Thornton KR, Foran AJ, Long AD. PMID: 23437004; PMCID: PMC3578756.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    19. A second-generation assembly of the Drosophila simulans genome provides new insights into patterns of lineage-specific divergence. Genome Res. 2013 Jan; 23(1):89-98. Hu TT, Eisen MB, Thornton KR, Andolfatto P. PMID: 22936249; PMCID: PMC3530686.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    20. The Drosophila melanogaster Genetic Reference Panel. Nature. 2012 Feb 08; 482(7384):173-8. Mackay TF, Richards S, Stone EA, Barbadilla A, Ayroles JF, Zhu D, Casillas S, Han Y, Magwire MM, Cridland JM, Richardson MF, Anholt RR, Barrón M, Bess C, Blankenburg KP, Carbone MA, Castellano D, Chaboub L, Duncan L, Harris Z, Javaid M, Jayaseelan JC, Jhangiani SN, Jordan KW, Lara F, Lawrence F, Lee SL, Librado P, Linheiro RS, Lyman RF, Mackey AJ, Munidasa M, Muzny DM, Nazareth L, Newsham I, Perales L, Pu LL, Qu C, Ràmia M, Reid JG, Rollmann SM, Rozas J, Saada N, Turlapati L, Worley KC, Wu YQ, Yamamoto A, Zhu Y, Bergman CM, Thornton KR, Mittelman D, Gibbs RA. PMID: 22318601; PMCID: PMC3683990.
      View in: PubMed   Mentions: 881     Fields:    Translation:AnimalsCells
    21. Experiments with the site frequency spectrum. Bull Math Biol. 2011 Apr; 73(4):829-72. Sainudiin R, Thornton K, Harlow J, Booth J, Stillman M, Yoshida R, Griffiths R, McVean G, Donnelly P. PMID: 21181503.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    22. Genome-wide analysis of a long-term evolution experiment with Drosophila. Nature. 2010 Sep 30; 467(7315):587-90. Burke MK, Dunham JP, Shahrestani P, Thornton KR, Rose MR, Long AD. PMID: 20844486.
      View in: PubMed   Mentions: 211     Fields:    Translation:Animals
    23. Validation of rearrangement break points identified by paired-end sequencing in natural populations of Drosophila melanogaster. Genome Biol Evol. 2010 Jan 13; 2:83-101. Cridland JM, Thornton KR. PMID: 20333226; PMCID: PMC2839345.
      View in: PubMed   Mentions: 34     Fields:    
    24. Automating approximate Bayesian computation by local linear regression. BMC Genet. 2009 Jul 07; 10:35. Thornton KR. PMID: 19583871; PMCID: PMC2712468.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    25. An approximate bayesian estimator suggests strong, recurrent selective sweeps in Drosophila. PLoS Genet. 2008 Sep 19; 4(9):e1000198. Jensen JD, Thornton KR, Andolfatto P. PMID: 18802463; PMCID: PMC2529407.
      View in: PubMed   Mentions: 58     Fields:    Translation:Animals
    26. Inferring selection in partially sequenced regions. Mol Biol Evol. 2008 Feb; 25(2):438-46. Jensen JD, Thornton KR, Aquadro CF. PMID: 18165259.
      View in: PubMed   Mentions: 10     Fields:    
    27. The neutral coalescent process for recent gene duplications and copy-number variants. Genetics. 2007 Oct; 177(2):987-1000. Thornton KR. PMID: 17720930; PMCID: PMC2034660.
      View in: PubMed   Mentions: 20     Fields:    
    28. A new approach for using genome scans to detect recent positive selection in the human genome. PLoS Biol. 2007 Jul; 5(7):e171. Tang K, Thornton KR, Stoneking M. PMID: 17579516; PMCID: PMC1892573.
      View in: PubMed   Mentions: 230     Fields:    Translation:Humans
    29. On the utility of linkage disequilibrium as a statistic for identifying targets of positive selection in nonequilibrium populations. Genetics. 2007 Aug; 176(4):2371-9. Jensen JD, Thornton KR, Bustamante CD, Aquadro CF. PMID: 17565955; PMCID: PMC1950638.
      View in: PubMed   Mentions: 49     Fields:    Translation:Animals
    30. Progress and prospects in mapping recent selection in the genome. Heredity (Edinb). 2007 Jun; 98(6):340-8. Thornton KR, Jensen JD, Becquet C, Andolfatto P. PMID: 17473869.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimals
    31. Controlling the false-positive rate in multilocus genome scans for selection. Genetics. 2007 Feb; 175(2):737-50. Thornton KR, Jensen JD. PMID: 17110489; PMCID: PMC1800626.
      View in: PubMed   Mentions: 86     Fields:    Translation:Humans
    32. X chromosomes and autosomes evolve at similar rates in Drosophila: no evidence for faster-X protein evolution. Genome Res. 2006 Apr; 16(4):498-504. Thornton K, Bachtrog D, Andolfatto P. PMID: 16520459; PMCID: PMC1457026.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    33. Approximate Bayesian inference reveals evidence for a recent, severe bottleneck in a Netherlands population of Drosophila melanogaster. Genetics. 2006 Mar; 172(3):1607-19. Thornton K, Andolfatto P. PMID: 16299396; PMCID: PMC1456302.
      View in: PubMed   Mentions: 145     Fields:    Translation:Animals
    34. Recombination and the properties of Tajima's D in the context of approximate-likelihood calculation. Genetics. 2005 Dec; 171(4):2143-8. Thornton K. PMID: 15998723; PMCID: PMC1456134.
      View in: PubMed   Mentions: 19     Fields:    
    35. Multilocus patterns of nucleotide variability and the demographic and selection history of Drosophila melanogaster populations. Genome Res. 2005 Jun; 15(6):790-9. Haddrill PR, Thornton KR, Charlesworth B, Andolfatto P. PMID: 15930491; PMCID: PMC1142469.
      View in: PubMed   Mentions: 137     Fields:    Translation:AnimalsCells
    36. Nucleotide variation and recombination along the fourth chromosome in Drosophila simulans. Genetics. 2004 Apr; 166(4):1783-94. Wang W, Thornton K, Emerson JJ, Long M. PMID: 15126398; PMCID: PMC1470817.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    37. Nucleotide variation along the Drosophila melanogaster fourth chromosome. Science. 2002 Jan 04; 295(5552):134-7. Wang W, Thornton K, Berry A, Long M. PMID: 11778050.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
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