Thornton, Kevin R.

Title(s)Associate Professor, Ecology & Evolutionary Biology
Phone(949) 824-0614
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    Collapse Research 
    Collapse Research Activities and Funding
    Population genomics of polygenic adaptation
    NIH/NIGMS R01GM115564Sep 16, 2015 - May 31, 2019
    Role: Principal Investigator
    Population genetics of gene duplications and copy-number variants in the Drosophi
    NIH/NIGMS R01GM085183Aug 1, 2009 - Jul 31, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Stetter MG, Thornton K, Ross-Ibarra J. Genetic architecture and selective sweeps after polygenic adaptation to distant trait optima. PLoS Genet. 2018 11; 14(11):e1007794. PMID: 30452452.
      View in: PubMed
    2. Kelleher J, Thornton KR, Ashander J, Ralph PL. Efficient pedigree recording for fast population genetics simulation. PLoS Comput Biol. 2018 Nov; 14(11):e1006581. PMID: 30383757.
      View in: PubMed
    3. Sanjak JS, Sidorenko J, Robinson MR, Thornton KR, Visscher PM. Evidence of directional and stabilizing selection in contemporary humans. Proc Natl Acad Sci U S A. 2018 01 02; 115(1):151-156. PMID: 29255044.
      View in: PubMed
    4. Rogers RL, Shao L, Thornton KR. Tandem duplications lead to novel expression patterns through exon shuffling in Drosophila yakuba. PLoS Genet. 2017 May; 13(5):e1006795. PMID: 28531189.
      View in: PubMed
    5. Sanjak JS, Long AD, Thornton KR. A Model of Compound Heterozygous, Loss-of-Function Alleles Is Broadly Consistent with Observations from Complex-Disease GWAS Datasets. PLoS Genet. 2017 01; 13(1):e1006573. PMID: 28103232.
      View in: PubMed
    6. Sanjak JS, Long AD, Thornton KR. Efficient Software for Multi-marker, Region-Based Analysis of GWAS Data. G3 (Bethesda). 2016 04 07; 6(4):1023-30. PMID: 26865700.
      View in: PubMed
    7. Rogers RL, Cridland JM, Shao L, Hu TT, Andolfatto P, Thornton KR. Tandem Duplications and the Limits of Natural Selection in Drosophila yakuba and Drosophila simulans. PLoS One. 2015; 10(7):e0132184. PMID: 26176952; PMCID: PMC4503668.
    8. Cridland JM, Thornton KR, Long AD. Gene expression variation in Drosophila melanogaster due to rare transposable element insertion alleles of large effect. Genetics. 2015 Jan; 199(1):85-93. PMID: 25335504.
      View in: PubMed
    9. Rogers RL, Shao L, Sanjak JS, Andolfatto P, Thornton KR. Revised annotations, sex-biased expression, and lineage-specific genes in the Drosophila melanogaster group. G3 (Bethesda). 2014 Oct 01; 4(12):2345-51. PMID: 25273863; PMCID: PMC4267930.
    10. Thornton KR. A C++ template library for efficient forward-time population genetic simulation of large populations. Genetics. 2014 Sep; 198(1):157-66. PMID: 24950894; PMCID: PMC4174927.
    11. Rogers RL, Cridland JM, Shao L, Hu TT, Andolfatto P, Thornton KR. Landscape of standing variation for tandem duplications in Drosophila yakuba and Drosophila simulans. Mol Biol Evol. 2014 Jul; 31(7):1750-66. PMID: 24710518; PMCID: PMC4069613.
    12. Baldwin-Brown JG, Long AD, Thornton KR. The power to detect quantitative trait loci using resequenced, experimentally evolved populations of diploid, sexual organisms. Mol Biol Evol. 2014 Apr; 31(4):1040-55. PMID: 24441104.
      View in: PubMed
    13. Cridland JM, Macdonald SJ, Long AD, Thornton KR. Abundance and distribution of transposable elements in two Drosophila QTL mapping resources. Mol Biol Evol. 2013 Oct; 30(10):2311-27. PMID: 23883524; PMCID: PMC3773372.
    14. Thornton KR, Foran AJ, Long AD. Properties and modeling of GWAS when complex disease risk is due to non-complementing, deleterious mutations in genes of large effect. PLoS Genet. 2013; 9(2):e1003258. PMID: 23437004; PMCID: PMC3578756.
    15. Hu TT, Eisen MB, Thornton KR, Andolfatto P. A second-generation assembly of the Drosophila simulans genome provides new insights into patterns of lineage-specific divergence. Genome Res. 2013 Jan; 23(1):89-98. PMID: 22936249; PMCID: PMC3530686.
    16. Mackay TF, Richards S, Stone EA, Barbadilla A, Ayroles JF, Zhu D, Casillas S, Han Y, Magwire MM, Cridland JM, Richardson MF, Anholt RR, Barrón M, Bess C, Blankenburg KP, Carbone MA, Castellano D, Chaboub L, Duncan L, Harris Z, Javaid M, Jayaseelan JC, Jhangiani SN, Jordan KW, Lara F, Lawrence F, Lee SL, Librado P, Linheiro RS, Lyman RF, Mackey AJ, Munidasa M, Muzny DM, Nazareth L, Newsham I, Perales L, Pu LL, Qu C, Ràmia M, Reid JG, Rollmann SM, Rozas J, Saada N, Turlapati L, Worley KC, Wu YQ, Yamamoto A, Zhu Y, Bergman CM, Thornton KR, Mittelman D, Gibbs RA. The Drosophila melanogaster Genetic Reference Panel. Nature. 2012 Feb 08; 482(7384):173-8. PMID: 22318601; PMCID: PMC3683990.
    17. Sainudiin R, Thornton K, Harlow J, Booth J, Stillman M, Yoshida R, Griffiths R, McVean G, Donnelly P. Experiments with the site frequency spectrum. Bull Math Biol. 2011 Apr; 73(4):829-72. PMID: 21181503.
      View in: PubMed
    18. Burke MK, Dunham JP, Shahrestani P, Thornton KR, Rose MR, Long AD. Genome-wide analysis of a long-term evolution experiment with Drosophila. Nature. 2010 Sep 30; 467(7315):587-90. PMID: 20844486.
      View in: PubMed
    19. Cridland JM, Thornton KR. Validation of rearrangement break points identified by paired-end sequencing in natural populations of Drosophila melanogaster. Genome Biol Evol. 2010 Jan 13; 2:83-101. PMID: 20333226; PMCID: PMC2839345.
    20. Thornton KR. Automating approximate Bayesian computation by local linear regression. BMC Genet. 2009 Jul 07; 10:35. PMID: 19583871; PMCID: PMC2712468.
    21. Jensen JD, Thornton KR, Andolfatto P. An approximate bayesian estimator suggests strong, recurrent selective sweeps in Drosophila. PLoS Genet. 2008 Sep 19; 4(9):e1000198. PMID: 18802463; PMCID: PMC2529407.
    22. Jensen JD, Thornton KR, Aquadro CF. Inferring selection in partially sequenced regions. Mol Biol Evol. 2008 Feb; 25(2):438-46. PMID: 18165259.
      View in: PubMed
    23. Thornton KR. The neutral coalescent process for recent gene duplications and copy-number variants. Genetics. 2007 Oct; 177(2):987-1000. PMID: 17720930; PMCID: PMC2034660.
    24. Tang K, Thornton KR, Stoneking M. A new approach for using genome scans to detect recent positive selection in the human genome. PLoS Biol. 2007 Jul; 5(7):e171. PMID: 17579516.
      View in: PubMed
    25. Jensen JD, Thornton KR, Bustamante CD, Aquadro CF. On the utility of linkage disequilibrium as a statistic for identifying targets of positive selection in nonequilibrium populations. Genetics. 2007 Aug; 176(4):2371-9. PMID: 17565955; PMCID: PMC1950638.
    26. Thornton KR, Jensen JD. Controlling the false-positive rate in multilocus genome scans for selection. Genetics. 2007 Feb; 175(2):737-50. PMID: 17110489; PMCID: PMC1800626.
    27. Thornton K, Bachtrog D, Andolfatto P. X chromosomes and autosomes evolve at similar rates in Drosophila: no evidence for faster-X protein evolution. Genome Res. 2006 Apr; 16(4):498-504. PMID: 16520459; PMCID: PMC1457026.
    28. Thornton K, Andolfatto P. Approximate Bayesian inference reveals evidence for a recent, severe bottleneck in a Netherlands population of Drosophila melanogaster. Genetics. 2006 Mar; 172(3):1607-19. PMID: 16299396; PMCID: PMC1456302.
    29. Thornton K. Recombination and the properties of Tajima's D in the context of approximate-likelihood calculation. Genetics. 2005 Dec; 171(4):2143-8. PMID: 15998723; PMCID: PMC1456134.
    30. Haddrill PR, Thornton KR, Charlesworth B, Andolfatto P. Multilocus patterns of nucleotide variability and the demographic and selection history of Drosophila melanogaster populations. Genome Res. 2005 Jun; 15(6):790-9. PMID: 15930491; PMCID: PMC1142469.
    31. Wang W, Thornton K, Emerson JJ, Long M. Nucleotide variation and recombination along the fourth chromosome in Drosophila simulans. Genetics. 2004 Apr; 166(4):1783-94. PMID: 15126398; PMCID: PMC1470817.
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