Kei Togashi

Title(s)Associate Clinical Professor, Anesthesiology and Perioperative Care
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
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    1. Gemcitabine Cooperates with Everolimus to Inhibit the Growth of and Sensitize Malignant Meningioma Cells to Apoptosis Induced by Navitoclax, an Inhibitor of Anti-Apoptotic BCL-2 Family Proteins. Cancers (Basel). 2022 Mar 27; 14(7). Yamamoto M, Suzuki S, Togashi K, Sugai A, Okada M, Kitanaka C. PMID: 35406478; PMCID: PMC8997110.
      View in: PubMed   Mentions:
    2. "Right" or Wrong Diagnosis? The Importance of Transesophageal Echocardiography to Assess the Etiology of Hypotension After Left Ventricular Assist Device Implantation. Chest. 2022 02; 161(2):e121-e125. Katrivesis KH, Elia J, Glovaci D, Lombardo D, Sagebin F, Nikravan S, Togashi K. PMID: 35131065; PMCID: PMC8941610.
      View in: PubMed   Mentions:
    3. Targeting Folate Metabolism Is Selectively Cytotoxic to Glioma Stem Cells and Effectively Cooperates with Differentiation Therapy to Eliminate Tumor-Initiating Cells in Glioma Xenografts. Int J Mol Sci. 2021 Oct 27; 22(21). Okada M, Suzuki S, Togashi K, Sugai A, Yamamoto M, Kitanaka C. PMID: 34769063; PMCID: PMC8583947.
      View in: PubMed   Mentions:
    4. Gemcitabine radiosensitization primes irradiated malignant meningioma cells for senolytic elimination by navitoclax. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab148. Yamamoto M, Sanomachi T, Suzuki S, Togashi K, Sugai A, Seino S, Sato A, Okada M, Kitanaka C. PMID: 34765973; PMCID: PMC8577526.
      View in: PubMed   Mentions:
    5. Lurasidone Sensitizes Cancer Cells to Osimertinib by Inducing Autophagy and Reduction of Survivin. Anticancer Res. 2021 Sep; 41(9):4321-4331. Suzuki S, Yamamoto M, Sanomachi T, Togashi K, Seino S, Sugai A, Yoshioka T, Okada M, Kitanaka C. PMID: 34475052.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Dexamethasone Sensitizes Cancer Stem Cells to Gemcitabine and 5-Fluorouracil by Increasing Reactive Oxygen Species Production through NRF2 Reduction. Life (Basel). 2021 Aug 27; 11(9). Suzuki S, Yamamoto M, Sanomachi T, Togashi K, Sugai A, Seino S, Yoshioka T, Okada M, Kitanaka C. PMID: 34575034; PMCID: PMC8470402.
      View in: PubMed   Mentions:
    7. Roles for hENT1 and dCK in gemcitabine sensitivity and malignancy of meningioma. Neuro Oncol. 2021 06 01; 23(6):945-954. Yamamoto M, Sanomachi T, Suzuki S, Uchida H, Yonezawa H, Higa N, Takajo T, Yamada Y, Sugai A, Togashi K, Seino S, Okada M, Sonoda Y, Hirano H, Yoshimoto K, Kitanaka C. PMID: 33556172; PMCID: PMC8168817.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. "Test and Standard Precautions"-Is It Enough to Protect Us From False-Negative Severe Acute Respiratory Syndrome Coronavirus 2 Test Results? Anesth Analg. 2021 Mar 01; 132(3):616-621. Bowdle A, Jelacic S, Togashi K, Wechter DG, Cain K. PMID: 33264121.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    9. Metastatic Orbital Tumor From Breast Ductal Carcinoma With Neuroendocrine Differentiation Initially Presenting as Ocular Symptoms: A Case Report and Literature Review. Front Endocrinol (Lausanne). 2021; 12:625663. Togashi K, Nishitsuka K, Hayashi S, Namba H, Goto S, Takeda Y, Suzuki S, Kato T, Yamada Y, Konno E, Yoshioka T, Yamakawa M, Sonoda Y, Suzuki T, Yamashita H. PMID: 33692758; PMCID: PMC7937957.
      View in: PubMed   Mentions:
    10. Inhibition of the Lipid Droplet-Peroxisome Proliferator-Activated Receptor α Axis Suppresses Cancer Stem Cell Properties. Genes (Basel). 2021 01 14; 12(1). Kuramoto K, Yamamoto M, Suzuki S, Togashi K, Sanomachi T, Kitanaka C, Okada M. PMID: 33466690; PMCID: PMC7828779.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    11. Train-of-four monitoring with the twitchview monitor electctromyograph compared to the GE NMT electromyograph and manual palpation. J Clin Monit Comput. 2021 12; 35(6):1477-1483. Bussey L, Jelacic S, Togashi K, Hulvershorn J, Bowdle A. PMID: 33165706.
      View in: PubMed   Mentions: 1     Fields:    
    12. Therapeutic targeting of pancreatic cancer stem cells by dexamethasone modulation of the MKP-1-JNK axis. J Biol Chem. 2020 12 25; 295(52):18328-18342. Suzuki S, Okada M, Sanomachi T, Togashi K, Seino S, Sato A, Yamamoto M, Kitanaka C. PMID: 33115754; PMCID: PMC7939393.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    13. Inhibition of Retinoblastoma Cell Growth by CEP1347 Through Activation of the P53 Pathway. Anticancer Res. 2020 Sep; 40(9):4961-4968. Togashi K, Okada M, Suzuki S, Sanomachi T, Seino S, Yamamoto M, Yamashita H, Kitanaka C. PMID: 32878784.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    14. Doxazosin, a Classic Alpha 1-Adrenoceptor Antagonist, Overcomes Osimertinib Resistance in Cancer Cells via the Upregulation of Autophagy as Drug Repurposing. Biomedicines. 2020 Aug 05; 8(8). Suzuki S, Yamamoto M, Sanomachi T, Togashi K, Sugai A, Seino S, Okada M, Yoshioka T, Kitanaka C. PMID: 32764319; PMCID: PMC7460424.
      View in: PubMed   Mentions: 4  
    15. Sinus of Valsalva Aneurysm Rupture Associated With a Ventricular Septal Defect: The Importance of Multi-Angle Assessment by Intraoperative Transesophageal Echocardiography. J Cardiothorac Vasc Anesth. 2020 Dec; 34(12):3376-3381. Togashi K, Paez FJG, Sheu RD. PMID: 32800621.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Development of an aviation-style computerized checklist displayed on a tablet computer for improving handoff communication in the post-anesthesia care unit. J Clin Monit Comput. 2021 05; 35(3):607-616. Jelacic S, Togashi K, Bussey L, Nair BG, Wu T, Boorman DJ, Bowdle A. PMID: 32405801.
      View in: PubMed   Mentions:    Fields:    
    17. Counting train-of-four twitch response: comparison of palpation to mechanomyography, acceleromyography, and electromyography. Br J Anaesth. 2020 06; 124(6):712-717. Bowdle A, Bussey L, Michaelsen K, Jelacic S, Nair B, Togashi K, Hulvershorn J. PMID: 32228867.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Aviation-Style Computerized Surgical Safety Checklist Displayed on a Large Screen and Operated by the Anesthesia Provider Improves Checklist Performance. Anesth Analg. 2020 02; 130(2):382-390. Jelacic S, Bowdle A, Nair BG, Togashi K, Boorman DJ, Cain KC, Lang JD, Dellinger EP. PMID: 31306243.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. Verteporfin inhibits oxidative phosphorylation and induces cell death specifically in glioma stem cells. FEBS J. 2020 05; 287(10):2023-2036. Kuramoto K, Yamamoto M, Suzuki S, Sanomachi T, Togashi K, Seino S, Kitanaka C, Okada M. PMID: 31868973.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    20. Spironolactone, a Classic Potassium-Sparing Diuretic, Reduces Survivin Expression and Chemosensitizes Cancer Cells to Non-DNA-Damaging Anticancer Drugs. Cancers (Basel). 2019 Oct 14; 11(10). Sanomachi T, Suzuki S, Togashi K, Sugai A, Seino S, Okada M, Yoshioka T, Kitanaka C, Yamamoto M. PMID: 31614999; PMCID: PMC6826935.
      View in: PubMed   Mentions: 6  
    21. Brexpiprazole Reduces Survivin and Reverses EGFR Tyrosine Kinase Inhibitor Resistance in Lung and Pancreatic Cancer. Anticancer Res. 2019 Sep; 39(9):4817-4828. Sanomachi T, Suzuki S, Togashi K, Seino S, Yoshioka T, Kitanaka C, Okada M, Yamamoto M. PMID: 31519584.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    22. Electronic Audit and Feedback With Positive Rewards Improve Anesthesia Provider Compliance With a Barcode-Based Drug Safety System. Anesth Analg. 2019 08; 129(2):418-425. Bowdle TA, Jelacic S, Nair B, Zucker F, Bussey LS, Togashi K, Yang JT, Lang J. PMID: 30320650.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Brexpiprazole, a Serotonin-Dopamine Activity Modulator, Can Sensitize Glioma Stem Cells to Osimertinib, a Third-Generation EGFR-TKI, via Survivin Reduction. Cancers (Basel). 2019 Jul 05; 11(7). Suzuki S, Yamamoto M, Sanomachi T, Togashi K, Sugai A, Seino S, Yoshioka T, Kitanaka C, Okada M. PMID: 31284441; PMCID: PMC6679129.
      View in: PubMed   Mentions: 9  
    24. In vitro and in vivo anti-tumor effects of brexpiprazole, a newly-developed serotonin-dopamine activity modulator with an improved safety profile. Oncotarget. 2019 May 28; 10(37):3547-3558. Suzuki S, Yamamoto M, Togashi K, Sanomachi T, Sugai A, Seino S, Yoshioka T, Kitanaka C, Okada M. PMID: 31191825; PMCID: PMC6544401.
      View in: PubMed   Mentions: 6     Fields:    
    25. AS602801 Sensitizes Ovarian Cancer Stem Cells to Paclitaxel by Down-regulating MDR1. Anticancer Res. 2019 Feb; 39(2):609-617. Yamamoto M, Suzuki S, Togashi K, Sanomachi T, Seino S, Kitanaka C, Okada M. PMID: 30711936.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    26. AS602801, an Anticancer Stem Cell Candidate Drug, Reduces Survivin Expression and Sensitizes A2780 Ovarian Cancer Stem Cells to Carboplatin and Paclitaxel. Anticancer Res. 2018 Dec; 38(12):6699-6706. Yamamoto M, Suzuki S, Togashi K, Sanomachi T, Seino S, Kitanaka C, Okada M. PMID: 30504379.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    27. AS602801, an Anti-Cancer Stem Cell Drug Candidate, Suppresses Gap-junction Communication Between Lung Cancer Stem Cells and Astrocytes. Anticancer Res. 2018 Sep; 38(9):5093-5099. Kuramoto K, Yamamoto M, Suzuki S, Sanomachi T, Togashi K, Seino S, Kitanaka C, Okada M. PMID: 30194154.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    28. Involvement of GLUT1-mediated glucose transport and metabolism in gefitinib resistance of non-small-cell lung cancer cells. Oncotarget. 2018 Aug 24; 9(66):32667-32679. Suzuki S, Okada M, Takeda H, Kuramoto K, Sanomachi T, Togashi K, Seino S, Yamamoto M, Yoshioka T, Kitanaka C. PMID: 30220973; PMCID: PMC6135698.
      View in: PubMed   Mentions: 18     Fields:    
    29. A Small-molecule Kinase Inhibitor, CEP-1347, Inhibits Survivin Expression and Sensitizes Ovarian Cancer Stem Cells to Paclitaxel. Anticancer Res. 2018 Aug; 38(8):4535-4542. Togashi K, Okada M, Yamamoto M, Suzuki S, Sanomachi T, Seino S, Yamashita H, Kitanaka C. PMID: 30061219.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    30. Assessing the Benefits of Preoperative Thoracic Epidural Placement for Lung Transplantation. J Cardiothorac Vasc Anesth. 2018 12; 32(6):2654-2661. McLean SR, von Homeyer P, Cheng A, Hall ML, Mulligan MS, Cain K, Togashi K. PMID: 29754733.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    31. Olanzapine, an Atypical Antipsychotic, Inhibits Survivin Expression and Sensitizes Cancer Cells to Chemotherapeutic Agents. Anticancer Res. 2017 11; 37(11):6177-6188. Sanomachi T, Suzuki S, Kuramoto K, Takeda H, Sakaki H, Togashi K, Seino S, Yoshioka T, Okada M, Kitanaka C. PMID: 29061799.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    32. Repositioning CEP-1347, a chemical agent originally developed for the treatment of Parkinson's disease, as an anti-cancer stem cell drug. Oncotarget. 2017 Nov 07; 8(55):94872-94882. Okada M, Takeda H, Sakaki H, Kuramoto K, Suzuki S, Sanomachi T, Togashi K, Seino S, Kitanaka C. PMID: 29212273; PMCID: PMC5706919.
      View in: PubMed   Mentions: 10     Fields:    
    33. Sinus of Valsalva Aneurysm Rupture Misdiagnosed as a Ventricular Septal Defect. Anesth Analg. 2017 May; 124(5):1437-1439. Togashi K, Hermsen JL, Joffe DC. PMID: 27622721.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. Ultrasound Identification of the Guidewire in the Brachiocephalic Vein for the Prevention of Inadvertent Arterial Catheterization During Internal Jugular Central Venous Catheter Placement. Anesth Analg. 2016 10; 123(4):896-900. Bowdle A, Jelacic S, Togashi K, Ferreira R. PMID: 27509224.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    35. Acute bioprosthetic mitral valve thrombosis. Intensive Care Med. 2016 Jun; 42(6):1073-4. Madathil R, Togashi K, VonHomeyer P, Hermsen JL. PMID: 26585789.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    36. A System for Anesthesia Drug Administration Using Barcode Technology: The Codonics Safe Label System and Smart Anesthesia Manager. Anesth Analg. 2015 Aug; 121(2):410-21. Jelacic S, Bowdle A, Nair BG, Kusulos D, Bower L, Togashi K. PMID: 24859078.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    37. Randomized pilot trial of intensive management of blood pressure or volume expansion in subarachnoid hemorrhage (IMPROVES). Neurosurgery. 2015 Feb; 76(2):125-34; discussion 134-5; quiz 135. Togashi K, Joffe AM, Sekhar L, Kim L, Lam A, Yanez D, Broeckel-Elrod JA, Moore A, Deem S, Khandelwal N, Souter MJ, Treggiari MM. PMID: 25549192.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    38. High-fidelity simulation of lung isolation with double-lumen endotracheal tubes and bronchial blockers in anesthesiology resident training. J Cardiothorac Vasc Anesth. 2014 Aug; 28(4):865-9. Failor E, Bowdle A, Jelacic S, Togashi K. PMID: 24231196.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    39. The use of TEE simulation in teaching basic echocardiography skills to senior anesthesiology residents. J Cardiothorac Vasc Anesth. 2013 Aug; 27(4):670-5. Jelacic S, Bowdle A, Togashi K, VonHomeyer P. PMID: 23849523.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    40. The effect of the pressure-volume curve for positive end-expiratory pressure titration on clinical outcomes in acute respiratory distress syndrome: a systematic review. J Intensive Care Med. 2014 Nov-Dec; 29(6):348-56. Hata JS, Togashi K, Kumar AB, Hodges LD, Kaiser EF, Tessmann PB, Faust CA, Sessler DI. PMID: 23855040.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    41. A multicenter evaluation of a compact, sterile, single-use pressure transducer for central venous catheter placement. Anesth Analg. 2013 May; 116(5):1018-1023. Togashi K, Nandate K, Hoaglan C, Sherman B, Bowdle A. PMID: 23492959.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansPHPublic Health
    42. Efficacy of an online education program for ultrasound diagnosis of pneumothorax. Anesthesiology. 2013 Mar; 118(3):715-21. Krishnan S, Kuhl T, Ahmed W, Togashi K, Ueda K. PMID: 23291625.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
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