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Imad Rashid Khan

Photo of Imad Rashid Khan
Title(s)Associate Clinical Professor, Neurology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(714) 456-6808
ORCID ORCID Icon0000-0002-2017-605X Additional info
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    Collapse Biography 
    Collapse education and training
    R. Adams Cowley Shock Trauma Center at the University of Maryland Medical Center, Baltimore, MD06/2017Neurocritical Care Fellowship
    Stony Brook University, Stony Brook, NY06/2015Neurology Residency
    Yale University School of Medicine - St. Mary's Hospital, Waterbury, CT06/2012Internship
    St. George's University School of Medicine, Grenada, West IndiesMD05/2011Medicine
    Rutgers, The State University of New Jersey, New Brunswick, NJBA06/2007Genetics

    Collapse Overview 
    Collapse overview
    I am a neurointensivist and clinical researcher with experience in multimodal, and particularly noninvasive, neuromonitoring in comatose patients with cardiac arrest, traumatic brain injury, and stroke. I lead a multidisciplinary collaboration that examines cerebral perfusion and neurovascular coupling in comatose cardiac arrest patients undergoing extracorporeal membrane oxygenation (R01 NS131967). Our laboratory also uses machine learning methods to examine neuroimaging, neurodiagnostics, and clinical data to predict outcomes after cardiac arrest. Finally, I serve as a Site PI for multicenter clinical trials including ICECAP (NCT04217551) and BOOST-3 (NCT03754114).

    Collapse Research 
    Collapse research activities and funding
    Non-Invasive Multi-Modal Neuromonitoring in Adults Undergoing Extracorporeal Membrane Oxygenation
    NIH R01NS131967Jan 2, 2024 - Nov 30, 2028
    Role: Multi-PI

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    Collapse Clinical Trials
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Inflammation and Neurological Outcomes in Cardiac Arrest - a Narrative Review of Serum Biomarker Investigations. J Intensive Care Med. 2025 Jul 13; 8850666251357536. Angulo SL, Johnson TW, Hutchinson L, Bhende B, Akbari Y, Cho SM, Khan IR. PMID: 40653818.
      View in: PubMed   Mentions:    Fields:    
    2. Wavelet and time-based cerebral autoregulation analysis using diffuse correlation spectroscopy on adults undergoing extracorporeal membrane oxygenation therapy. PLoS One. 2024; 19(10):e0299752. Dar IA, Khan IR, Johnson TW, Helmy SM, Cardona JI, Escobar S, Selioutski O, Marinescu MA, Zhang CT, Proctor AR, AbdAllah N, Busch DR, Maddox RK, Choe R. PMID: 39471182; PMCID: PMC11521301.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Neurosurgical Procedures in Patients Requiring Extracorporeal Membrane Oxygenation. Crit Care Explor. 2024 Oct; 6(10):e1166. Lee R, Helmy S, Cardona J, Zhao D, Rector R, Rabin J, Mazzeffi M, Cho SM, Parikh G, Morris NA, Khan I. PMID: 39440348; PMCID: PMC11495759.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. Rationale and Design for the BLOCK-SAH Study (Pterygopalatine Fossa Block as an Opioid-Sparing Treatment for Acute Headache in Aneurysmal Subarachnoid Hemorrhage): A Phase II, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial with a Sequential Parallel Comparison Design. Neurocrit Care. 2025 Feb; 42(1):290-300. Busl KM, Smith CR, Troxel AB, Fava M, Illenberger N, Pop R, Yang W, Frota LM, Gao H, Shan G, Hoh BL, Maciel CB, BLOCK-SAH Investigators. PMID: 39138719; PMCID: PMC11810580.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    5. Influence of Cooling duration on Efficacy in Cardiac Arrest Patients (ICECAP): study protocol for a multicenter, randomized, adaptive allocation clinical trial to identify the optimal duration of induced hypothermia for neuroprotection in comatose, adult survivors of after out-of-hospital cardiac arrest. Trials. 2024 Jul 23; 25(1):502. Meurer WJ, Schmitzberger FF, Yeatts S, Ramakrishnan V, Abella B, Aufderheide T, Barsan W, Benoit J, Berry S, Black J, Bozeman N, Broglio K, Brown J, Brown K, Carlozzi N, Caveney A, Cho SM, Chung-Esaki H, Clevenger R, Conwit R, Cooper R, Crudo V, Daya M, Harney D, Hsu C, Johnson NJ, Khan I, Khosla S, Kline P, Kratz A, Kudenchuk P, Lewis RJ, Madiyal C, Meyer S, Mosier J, Mouammar M, Neth M, O'Neil B, Paxton J, Perez S, Perman S, Sozener C, Speers M, Spiteri A, Stevenson V, Sunthankar K, Tonna J, Youngquist S, Geocadin R, Silbergleit R, ICECAP trial investigators. PMID: 39044295; PMCID: PMC11264458.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    6. After ECMO Decannulation, Are Patients Thriving or Just Surviving? Neurology. 2024 Feb 13; 102(3):e209144. Khan IR, Morris NA. PMID: 38181325; PMCID: PMC11097770.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Neuromonitoring of Pediatric and Adult Extracorporeal Membrane Oxygenation Patients: The Importance of Continuous Bedside Tools in Driving Neuroprotective Clinical Care. ASAIO J. 2024 03 01; 70(3):167-176. Tabet M, Custer C, Khan IR, Sanford E, Sharma J, Choe R, Singh S, Sirsi D, Olson DM, Morriss MC, Raman L, Busch DR. PMID: 38051987; PMCID: PMC11833774.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Correlations Between Quantitative EEG Parameters and Cortical Blood Flow in Patients Undergoing Extracorporeal Membrane Oxygenation With and Without Encephalopathy. J Clin Neurophysiol. 2024 Nov 01; 41(7):597-605. Khan IR, Dar IA, Johnson TW, Loose E, Xu YY, Santiago E, Donohue KL, Marinescu MA, Gosev I, Schifitto G, Maddox RK, Busch DR, Choe R, Selioutski O. PMID: 37934074.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Mechanical Thrombectomy for Ischemic Stroke Secondary to Large Vessel Occlusions in Patients on Extracorporeal Membrane Oxygenation. Cerebrovasc Dis. 2023; 52(5):532-538. Kohli G, George DD, Grenga A, Santangelo G, Gosev I, Schartz D, Kessler A, Khan I, Barrus B, Gu Y, Bhalla T, Mattingly TK, Bender MT. PMID: 36716722.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. Cerebral Blood Flow Hemispheric Asymmetry in Comatose Adults Receiving Extracorporeal Membrane Oxygenation. Front Neurosci. 2022; 16:858404. Johnson TW, Dar IA, Donohue KL, Xu YY, Santiago E, Selioutski O, Marinescu MA, Maddox RK, Wu TT, Schifitto G, Gosev I, Choe R, Khan IR. PMID: 35478849; PMCID: PMC9036108.
      View in: PubMed   Mentions: 2  
    11. Brain Histopathology of Adult Decedents After Extracorporeal Membrane Oxygenation. Neurology. 2021 03 02; 96(9):e1278-e1289. Khan IR, Gu Y, George BP, Malone L, Conway KS, Francois F, Donlon J, Quazi N, Reddi A, Ho CY, Herr DL, Johnson MD, Parikh GY. PMID: 33472914; PMCID: PMC8055323.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    12. Towards detection of brain injury using multimodal non-invasive neuromonitoring in adults undergoing extracorporeal membrane oxygenation. Biomed Opt Express. 2020 Nov 01; 11(11):6551-6569. Dar IA, Khan IR, Maddox RK, Selioutski O, Donohue KL, Marinescu MA, Prasad SM, Quazi NH, Donlon JS, Loose EA, Ramirez GA, Ren J, Majeski JB, Abramson K, Durduran T, Busch DR, Choe R. PMID: 33282508; PMCID: PMC7687959.
      View in: PubMed   Mentions: 7  
    13. Cognitive, Psychiatric, and Quality of Life Outcomes in Adult Survivors of Extracorporeal Membrane Oxygenation Therapy: A Scoping Review of the Literature. Crit Care Med. 2020 10; 48(10):e959-e970. Khan IR, Saulle M, Oldham MA, Weber MT, Schifitto G, Lee HB. PMID: 32886470.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    14. Mechanical ventilation in aneurysmal subarachnoid hemorrhage: systematic review and recommendations. Crit Care. 2020 09 24; 24(1):575. Towner JE, Rahmani R, Zammit CG, Khan IR, Paul DA, Bhalla T, Roberts DE. PMID: 32972406; PMCID: PMC7512211.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    15. Proceedings from the Neurotherapeutics Symposium on Neurological Emergencies: Shaping the Future of Neurocritical Care. Neurocrit Care. 2020 12; 33(3):636-645. Simpkins AN, Busl KM, Amorim E, Barnett-Tapia C, Cervenka MC, Dhakar MB, Etherton MR, Fung C, Griggs R, Holloway RG, Kelly AG, Khan IR, Lizarraga KJ, Madagan HG, Onweni CL, Mestre H, Rabinstein AA, Rubinos C, Dionisio-Santos DA, Youn TS, Merck LH, Maciel CB, Neurotherapeutics Symposium 2019. PMID: 32959201; PMCID: PMC7736003.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansPHPublic Health
    16. Regional Cerebral Oximetry as an Indicator of Acute Brain Injury in Adults Undergoing Veno-Arterial Extracorporeal Membrane Oxygenation-A Prospective Pilot Study. Front Neurol. 2018; 9:993. Khan I, Rehan M, Parikh G, Zammit C, Badjatia N, Herr D, Kon Z, Hogue C, Mazzeffi M. PMID: 30532730; PMCID: PMC6265435.
      View in: PubMed   Mentions: 12  
    17. Continuous Vital Sign Analysis to Predict Secondary Neurological Decline After Traumatic Brain Injury. Front Neurol. 2018; 9:761. Melinosky C, Yang S, Hu P, Li H, Miller CHT, Khan I, Mackenzie C, Chang WT, Parikh G, Stein D, Badjatia N. PMID: 30319521; PMCID: PMC6167472.
      View in: PubMed   Mentions: 10  
    18. Esophageal Cooling Device Versus Other Temperature Modulation Devices for Therapeutic Normothermia in Subarachnoid and Intracranial Hemorrhage. Ther Hypothermia Temp Manag. 2018 Mar; 8(1):53-58. Khan I, Haymore J, Barnaba B, Armahizer M, Melinosky C, Bautista MA, Blaber B, Chang WT, Parikh G, Motta M, Badjatia N. PMID: 29236581; PMCID: PMC5831898.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    19. Emergent carotid stenting and intra-arterial abciximab in acute ischemic stroke due to tandem occlusion. Br J Neurosurg. 2017 Oct; 31(5):573-579. Al-Mufti F, Amuluru K, Manning NW, Khan I, Peeling L, Gandhi CD, Prestigiacomo CJ, Pushchinska G, Fiorella D, Woo HH. PMID: 28298139.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
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