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Darci Jones Trader

Title(s)Associate Professor, Pharmaceutical Sciences
SchoolSchool of Pharmacy and Pharmaceutical Sciences
Address101 Theory, Suite 100
Irvine CA 92697-3958
Phone(949) 824-7995
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    Collapse Research 
    Collapse Research Activities and Funding
    Targeted Protein Degradation Utilizing Rpn-13
    NIH R01GM163338May 1, 2026 - Jan 31, 2030
    Role: Principal Investigator
    Monitoring and Manipulating the Activity of the Immunoproteasome with Small Molecules
    NIH R01AI150847Jul 2, 2020 - Jun 30, 2024
    Role: Principal Investigator
    Development of Activity-Based Chemical Reporters to Differentiate Proteasome Isoforms in Cells
    NIH R21GM131206Sep 1, 2019 - Aug 31, 2021
    Role: Principal Investigator
    Discovery of Constrained Peptoid Oligomers for Novel Therapy of Multiple Myeloma
    NIH F32CA186612Jul 1, 2014 - Jun 30, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Impact of Two Small-Molecule Proteasome Stimulators on Cellular Growth and Metabolism. Chembiochem. 2026 May 14; 27(9):e70362. Kragness KA, Trader DJ. PMID: 42107081.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. In Vivo Time-Lapse Imaging Reveals Differential Activity-Induced Regulation of Proteasome Activity in Subcellular Regions of the Optic Tectum in Xenopus laevis Tadpoles. ACS Chem Neurosci. 2026 Apr 14. Lin JM, Konadu BB, Trader DJ, He HY. PMID: 41978499.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. You are what you degrade: tracking the cellular fates of the proteasomal degradome. Mol Omics. 2026 Jan 22; 22(1). Dantis DS, Trader DJ. PMID: 41696906.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Increasing Proteasome Activity to Alter XBP1 Signaling of the UPR Pathway. Chembiochem. 2026 Jan; 27(2):e202500854. Kragness KA, Trader DJ. PMID: 41619229.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Discovery of a First-in-Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity. Angew Chem Int Ed Engl. 2026 Feb 09; 65(7):e25126. Qu Z, Meke FN, Zhang Z, Krabill AD, Muli CS, Jassim BA, Dong J, Nguyen QD, Bai Y, Li J, Miao Y, Asadi B, Johnson LM, Miao J, Trader DJ, Tao WA, Zhang ZY. PMID: 41454526; PMCID: PMC12833730.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Synthesis of Immunoproteasome N-Degron Prodrugs for Selective Protein Degradation. Curr Protoc. 2025 Dec; 5(12):e70278. Loy CA, Harris TJ, Trader DJ. PMID: 41389145.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Small molecule proteasome activation: comparative structural analysis of known stimulators. Bioorg Med Chem. 2026 Jan 01; 132:118470. Osman JM, Trader DJ. PMID: 41223714.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. From Breakdown to Breakthrough: Immunoproteasomes Could Revolutionize Immunotherapies. J Med Chem. 2025 Oct 23; 68(20):20964-20971. Loy CA, Trader DJ. PMID: 41082717.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    9. Oleanolic Acid Amide Derivatives as 20s Proteasome Stimulators. Chembiochem. 2025 Oct 03; 26(19):e202500199. Osman JM, Dantis DS, King H, Trader DJ. PMID: 40970301; PMCID: PMC12687569.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. Degradation of Abl Utilizing an Immunoproteasome N-Degron Prodrug. J Med Chem. 2025 Aug 28; 68(16):17565-17573. Loy CA, Harris TJ, Vinogradsky SE, Trader DJ. PMID: 40830068.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. Synthesis and Application of BRD4-Targeting ByeTACs (Bypassing E-Ligase Targeting Chimeras). Curr Protoc. 2025 Aug; 5(8):e70196. Loy CA, Harris TJ, Trader DJ. PMID: 40788235.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    12. NMR-Guided Studies to Establish the Binding Interaction between a Peptoid and Protein. J Am Chem Soc. 2025 Aug 06; 147(31):27403-27412. Muli CS, Xie D, Post CB, Trader DJ. PMID: 40663344; PMCID: PMC12310119.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    13. Exploring the immunoproteasome's substrate preferences for improved hydrolysis and selectivity. RSC Chem Biol. 2025 Jul 30; 6(8):1306-1312. Muli CS, Loy CA, Trader DJ. PMID: 40635863; PMCID: PMC12235443.
      View in: PubMed   Mentions: 1  
    14. ByeTAC: Bypassing E-Ligase-Targeting Chimeras for Direct Proteasome Degradation. J Med Chem. 2025 May 08; 68(9):9694-9705. Loy CA, Ali EMH, Seabrook LJ, Harris TJ, Kragness KA, Albrecht L, Trader DJ. PMID: 40252035.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    15. Immunoproteasome as a Target for Prodrugs. J Med Chem. 2025 Mar 27; 68(6):6507-6517. Muli CS, Loy CA, Trader DJ. PMID: 40098355.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. Activation of the 20S proteasome core particle prevents cell death induced by oxygen- and glucose deprivation in cultured cortical neurons. Apoptosis. 2025 06; 30(5-6):1372-1390. Salazar IL, Curcio M, Mele M, Vetrone R, Frisari S, Costa RO, Caldeira MV, Trader DJ, Duarte CB. PMID: 40095265; PMCID: PMC12167278.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    17. Exploration of degrons and their ability to mediate targeted protein degradation. RSC Med Chem. 2025 Mar 19; 16(3):1067-1082. Harris TJ, Trader DJ. PMID: 39867589; PMCID: PMC11758578.
      View in: PubMed   Mentions: 3  
    18. Synthesis and Application of a Versatile Immunoproteasome Activity Probe. Chembiochem. 2024 Dec 02; 25(23):e202400571. Halder S, Loy CA, Trader DJ. PMID: 39363730; PMCID: PMC11633459.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    19. Synthesis and Application of a Caged Bioluminescent Probe for the Immunoproteasome. Curr Protoc. 2024 Nov; 4(11):e70057. Loy CA, Trader DJ. PMID: 39574360; PMCID: PMC11648997.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins. Nat Chem Biol. 2024 Dec; 20(12):1566-1576. Seabrook LJ, Franco CN, Loy CA, Osman J, Fredlender C, Zimak J, Campos M, Nguyen ST, Watson RL, Levine SR, Khalil MF, Sumigray K, Trader DJ, Albrecht LV. PMID: 39414979.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    21. Primed for Interactions: Investigating the Primed Substrate Channel of the Proteasome for Improved Molecular Engagement. Molecules. 2024 Jul 17; 29(14). Loy CA, Trader DJ. PMID: 39064934; PMCID: PMC11279888.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    22. Caged aminoluciferin probe for bioluminescent immunoproteasome activity analysis. RSC Chem Biol. 2024 Aug 28; 5(9):877-883. Loy CA, Trader DJ. PMID: 39211472; PMCID: PMC11352960.
      View in: PubMed   Mentions: 1  
    23. AM404 Analogs as Activators of the 20S Isoform of the Human Proteasome. Chembiochem. 2024 Jun 17; 25(12):e202400284. Salazar-Chaparro A, Kragness K, Feleciano D, Trader DJ. PMID: 38609329.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    24. Natural Product-Inspired Molecules for Covalent Inhibition of SHP2 Tyrosine Phosphatase. Tetrahedron. 2024 Apr 28; 156. Liang W, Krabill AD, Gallagher KS, Muli C, Qu Z, Trader D, Zhang ZY, Dai M. PMID: 38618612; PMCID: PMC11008911.
      View in: PubMed   Mentions: 3     Fields:    
    25. ByeTAC: Bypassing an E3 Ligase for Targeted Protein Degradation. bioRxiv. 2024 Jan 21. Ali EMH, Loy CA, Trader DJ. PMID: 38293213; PMCID: PMC10827187.
      View in: PubMed   Mentions:
    26. Discovery and Development of Cyclic Peptide Proteasome Stimulators. Chembiochem. 2024 02 01; 25(3):e202300671. Nelson S, Harris TJ, Muli CS, Maresh ME, Baker B, Smith C, Neumann C, Trader DJ, Parkinson EI. PMID: 38055197; PMCID: PMC10993313.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    27. Discovery of a non-covalent ligand for Rpn-13, a therapeutic target for hematological cancers. Bioorg Med Chem Lett. 2023 10 15; 95:129485. Loy CA, Muli CS, Ali EMH, Xie D, Ahmed MH, Beth Post C, Trader DJ. PMID: 37714498; PMCID: PMC10639113.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    28. 20S proteasome hydrolysis of LLVY substrates to determine preferences for moieties in its primed substrate channel. Bioorg Med Chem Lett. 2023 04 01; 85:129233. Muli CS, Trader DJ. PMID: 36905968; PMCID: PMC10165662.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    29. Oleic amide derivatives as small molecule stimulators of the human proteasome's core particle. RSC Med Chem. 2022 Sep 21; 13(9):1077-1081. Halder S, Macatangay NJ, Zerfas BL, Salazar-Chaparro AF, Trader DJ. PMID: 36324496; PMCID: PMC9491356.
      View in: PubMed   Mentions: 6  
    30. Synthesis and Application of a Clickable Epoxomicin-Based Probe for Proteasome Activity Analysis. Curr Protoc. 2022 Jul; 2(7):e490. Salazar-Chaparro AF, Halder S, Trader DJ. PMID: 35849029; PMCID: PMC9354099.
      View in: PubMed   Mentions: 6     Fields:    
    31. Solid-Phase Synthesis and Application of a Clickable Version of Epoxomicin for Proteasome Activity Analysis. Chembiochem. 2022 04 05; 23(7):e202100710. Salazar-Chaparro AF, Halder S, Maresh ME, Trader DJ. PMID: 35107861; PMCID: PMC9122039.
      View in: PubMed   Mentions: 2     Fields:    
    32. Hyperexcitability and Pharmacological Responsiveness of Cortical Neurons Derived from Human iPSCs Carrying Epilepsy-Associated Sodium Channel Nav1.2-L1342P Genetic Variant. J Neurosci. 2021 12 08; 41(49):10194-10208. Que Z, Olivero-Acosta MI, Zhang J, Eaton M, Tukker AM, Chen X, Wu J, Xie J, Xiao T, Wettschurack K, Yunis L, Shafer JM, Schaber JA, Rochet JC, Bowman AB, Yuan C, Huang Z, Hu CD, Trader DJ, Skarnes WC, Yang Y. PMID: 34716231; PMCID: PMC8660047.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    33. A Yeast Chronological Lifespan Assay to Assess Activity of Proteasome Stimulators. Chembiochem. 2021 Aug 03; 22(15):2553-2560. Maresh ME, Chen P, Hazbun TR, Trader DJ. PMID: 34043860; PMCID: PMC8478123.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    34. Identification of a covalent binder to the oncoprotein gankyrin using a NIR-Based OBOC screening method. RSC Adv. 2021 Mar 29; 11(21):12794-12801. Maresh ME, Zerfas BL, Wuthrich BS, Trader DJ. PMID: 35423814; PMCID: PMC8697547.
      View in: PubMed   Mentions: 1  
    35. Approaches to Evaluate the Impact of a Small-Molecule Binder to a Noncatalytic Site of the Proteasome. Chembiochem. 2021 06 02; 22(11):1961-1965. Tian W, Maresh ME, Trader DJ. PMID: 33617657; PMCID: PMC8329144.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    36. Protein degradation profile reveals dynamic nature of 20S proteasome small molecule stimulation. RSC Chem Biol. 2021 Apr 01; 2(2):636-644. Coleman RA, Mohallem R, Aryal UK, Trader DJ. PMID: 34458805; PMCID: PMC8341874.
      View in: PubMed   Mentions: 12  
    37. Methods for the discovery of small molecules to monitor and perturb the activity of the human proteasome. Future Med Chem. 2021 01; 13(2):99-116. Maresh ME, Salazar-Chaparro AF, Trader DJ. PMID: 33275045; PMCID: PMC7857359.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    38. Fluorescent Probes with Unnatural Amino Acids to Monitor Proteasome Activity in Real-Time. ACS Chem Biol. 2020 09 18; 15(9):2588-2596. Zerfas BL, Coleman RA, Salazar-Chaparro AF, Macatangay NJ, Trader DJ. PMID: 32786259; PMCID: PMC8319958.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    39. Designing Chimeric Molecules for Drug Discovery by Leveraging Chemical Biology. J Med Chem. 2020 03 12; 63(5):1908-1928. Borsari C, Trader DJ, Tait A, Costi MP. PMID: 32023055; PMCID: PMC7997565.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    40. Discovery of a Small Molecule Probe of Rpn-6, an Essential Subunit of the 26S Proteasome. ACS Chem Biol. 2020 02 21; 15(2):554-561. Tian W, Trader DJ. PMID: 31877015.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    41. Synthesis and Application of an Activity-Based Peptide-Peptoid Hybrid Probe for the Immunoproteasome. Curr Protoc Chem Biol. 2019 12; 11(4):e76. Zerfas BL, Trader DJ. PMID: 31860787; PMCID: PMC6927525.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    42. The Immunoproteasome: An Emerging Target in Cancer and Autoimmune and Neurological Disorders. J Med Chem. 2020 03 12; 63(5):1841-1858. Zerfas BL, Maresh ME, Trader DJ. PMID: 31670954.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    43. Methods to Discover and Evaluate Proteasome Small Molecule Stimulators. Molecules. 2019 Jun 25; 24(12). Coleman RA, Trader DJ. PMID: 31242677; PMCID: PMC6630500.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    44. Small-Molecule Inhibitors of the Proteasome's Regulatory Particle. Chembiochem. 2019 07 15; 20(14):1739-1753. Muli CS, Tian W, Trader DJ. PMID: 30740849; PMCID: PMC6765334.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    45. Monitoring the Immunoproteasome in Live Cells Using an Activity-Based Peptide-Peptoid Hybrid Probe. J Am Chem Soc. 2019 04 03; 141(13):5252-5260. Zerfas BL, Trader DJ. PMID: 30862160; PMCID: PMC7389183.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    46. Development of a Method To Prioritize Protein-Ligand Pairs on Beads Using Protein Conjugated to a Near-IR Dye. ACS Comb Sci. 2019 03 11; 21(3):223-228. Maresh ME, Trader DJ. PMID: 30677288.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    47. Rubiscolins are naturally occurring G protein-biased delta opioid receptor peptides. Eur Neuropsychopharmacol. 2019 03; 29(3):450-456. Cassell RJ, Mores KL, Zerfas BL, Mahmoud AH, Lill MA, Trader DJ, van Rijn RM. PMID: 30591345; PMCID: PMC6421079.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    48. Analysis of chain length, substitution patterns, and unsaturation of AM-404 derivatives as 20S proteasome stimulators. Bioorg Med Chem Lett. 2019 02 01; 29(3):420-423. Coleman RA, Muli CS, Zhao Y, Bhardwaj A, Newhouse TR, Trader DJ. PMID: 30587447; PMCID: PMC6348054.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    49. All About the Core: A Therapeutic Strategy to Prevent Protein Accumulation with Proteasome Core Particle Stimulators. ACS Pharmacol Transl Sci. 2018 Nov 09; 1(2):140-142. Coleman RA, Trader DJ. PMID: 32219211; PMCID: PMC7088911.
      View in: PubMed   Mentions: 14  
    50. A Sensitive High-Throughput Screening Method for Identifying Small Molecule Stimulators of the Core Particle of the Proteasome. Curr Protoc Chem Biol. 2018 12; 10(4):e52. Coleman RA, Trader DJ. PMID: 30285317; PMCID: PMC6263736.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    51. Development and Application of a Sensitive Peptide Reporter to Discover 20S Proteasome Stimulators. ACS Comb Sci. 2018 05 14; 20(5):269-276. Coleman RA, Trader DJ. PMID: 29553711.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    52. Establishment of a suite of assays that support the discovery of proteasome stimulators. Biochim Biophys Acta Gen Subj. 2017 Apr; 1861(4):892-899. Trader DJ, Simanski S, Dickson P, Kodadek T. PMID: 28065760; PMCID: PMC5366797.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    53. Chemoselective enrichment as a tool to increase access to bioactive natural products: Case study borrelidin. Bioorg Med Chem Lett. 2015 Nov 01; 25(21):4767-4769. Trader DJ, Carlson EE. PMID: 26255540.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    54. A reversible and highly selective inhibitor of the proteasomal ubiquitin receptor rpn13 is toxic to multiple myeloma cells. J Am Chem Soc. 2015 May 20; 137(19):6312-9. Trader DJ, Simanski S, Kodadek T. PMID: 25914958; PMCID: PMC4455945.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    55. Taming of a superbase for selective phenol desilylation and natural product isolation. J Org Chem. 2013 Jul 19; 78(14):7349-55. Trader DJ, Carlson EE. PMID: 23815363.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    56. Integrated metabolomics approach facilitates discovery of an unpredicted natural product suite from Streptomyces coelicolor M145. ACS Chem Biol. 2013 Sep 20; 8(9):2009-16. Sidebottom AM, Johnson AR, Karty JA, Trader DJ, Carlson EE. PMID: 23777274; PMCID: PMC3783606.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    57. Chemoselective hydroxyl group transformation: an elusive target. Mol Biosyst. 2012 Oct; 8(10):2484-93. Trader DJ, Carlson EE. PMID: 22695722; PMCID: PMC3430791.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    58. Siloxyl ether functionalized resins for chemoselective enrichment of carboxylic acids. Org Lett. 2011 Oct 21; 13(20):5652-5. Trader DJ, Carlson EE. PMID: 21957886; PMCID: PMC3215773.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    59. Chemoselective enrichment for natural products discovery. Chem Sci. 2011 Apr 01; 2(4):760-764. Odendaal AY, Trader DJ, Carlson EE. PMID: 24926410; PMCID: PMC4051302.
      View in: PubMed   Mentions: 16  
    60. Discrimination between schizophrenic and control subjects by means of plasma dehydroepiandrosterone measurements. J Clin Endocrinol Metab. 1981 Feb; 52(2):181-6. Erb JL, Kadane JB, Tourney G, Mickelsen R, Trader D, Szabo R, Davis V. PMID: 6450774.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
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