Darci Jones Trader

Title(s)Associate Professor, Pharmaceutical Sciences
SchoolSchool of Pharmacy and Pharmaceutical Sciences
Address101 Theory, Suite 100
Irvine CA 92697-3958
Phone(949) 824-7995
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. AM404 Analogs as Activators of the 20S Isoform of the Human Proteasome. Chembiochem. 2024 Apr 12; e202400284. Salazar A, Kragness K, Feleciano D, Trader DJ. PMID: 38609329.
      View in: PubMed   Mentions:
    2. ByeTAC: Bypassing an E3 Ligase for Targeted Protein Degradation. bioRxiv. 2024 Jan 21. Ali EMH, Loy CA, Trader DJ. PMID: 38293213; PMCID: PMC10827187.
      View in: PubMed   Mentions:
    3. Discovery and Development of Cyclic Peptide Proteasome Stimulators. Chembiochem. 2024 02 01; 25(3):e202300671. Nelson S, Harris TJ, Muli CS, Maresh ME, Baker B, Smith C, Neumann C, Trader DJ, Parkinson EI. PMID: 38055197; PMCID: PMC10993313.
      View in: PubMed   Mentions:    Fields:    
    4. Discovery of a non-covalent ligand for Rpn-13, a therapeutic target for hematological cancers. Bioorg Med Chem Lett. 2023 10 15; 95:129485. Loy CA, Muli CS, Ali EMH, Xie D, Ahmed MH, Beth Post C, Trader DJ. PMID: 37714498; PMCID: PMC10639113.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. 20S proteasome hydrolysis of LLVY substrates to determine preferences for moieties in its primed substrate channel. Bioorg Med Chem Lett. 2023 04 01; 85:129233. Muli CS, Trader DJ. PMID: 36905968; PMCID: PMC10165662.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Oleic amide derivatives as small molecule stimulators of the human proteasome's core particle. RSC Med Chem. 2022 Sep 21; 13(9):1077-1081. Halder S, Macatangay NJ, Zerfas BL, Salazar-Chaparro AF, Trader DJ. PMID: 36324496; PMCID: PMC9491356.
      View in: PubMed   Mentions:
    7. Synthesis and Application of a Clickable Epoxomicin-Based Probe for Proteasome Activity Analysis. Curr Protoc. 2022 Jul; 2(7):e490. Salazar-Chaparro AF, Halder S, Trader DJ. PMID: 35849029; PMCID: PMC9354099.
      View in: PubMed   Mentions: 2     Fields:    
    8. Solid-Phase Synthesis and Application of a Clickable Version of Epoxomicin for Proteasome Activity Analysis. Chembiochem. 2022 04 05; 23(7):e202100710. Salazar-Chaparro AF, Halder S, Maresh ME, Trader DJ. PMID: 35107861; PMCID: PMC9122039.
      View in: PubMed   Mentions:    Fields:    
    9. Hyperexcitability and Pharmacological Responsiveness of Cortical Neurons Derived from Human iPSCs Carrying Epilepsy-Associated Sodium Channel Nav1.2-L1342P Genetic Variant. J Neurosci. 2021 12 08; 41(49):10194-10208. Que Z, Olivero-Acosta MI, Zhang J, Eaton M, Tukker AM, Chen X, Wu J, Xie J, Xiao T, Wettschurack K, Yunis L, Shafer JM, Schaber JA, Rochet JC, Bowman AB, Yuan C, Huang Z, Hu CD, Trader DJ, Skarnes WC, Yang Y. PMID: 34716231; PMCID: PMC8660047.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    10. A Yeast Chronological Lifespan Assay to Assess Activity of Proteasome Stimulators. Chembiochem. 2021 08 03; 22(15):2553-2560. Maresh ME, Chen P, Hazbun TR, Trader DJ. PMID: 34043860; PMCID: PMC8478123.
      View in: PubMed   Mentions: 1     Fields:    
    11. Identification of a covalent binder to the oncoprotein gankyrin using a NIR-Based OBOC screening method. RSC Adv. 2021 Mar 29; 11(21):12794-12801. Maresh ME, Zerfas BL, Wuthrich BS, Trader DJ. PMID: 35423814; PMCID: PMC8697547.
      View in: PubMed   Mentions:
    12. Approaches to Evaluate the Impact of a Small-Molecule Binder to a Noncatalytic Site of the Proteasome. Chembiochem. 2021 06 02; 22(11):1961-1965. Tian W, Maresh ME, Trader DJ. PMID: 33617657; PMCID: PMC8329144.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    13. Protein degradation profile reveals dynamic nature of 20S proteasome small molecule stimulation. RSC Chem Biol. 2021 Apr 01; 2(2):636-644. Coleman RA, Mohallem R, Aryal UK, Trader DJ. PMID: 34458805; PMCID: PMC8341874.
      View in: PubMed   Mentions: 9  
    14. Methods for the discovery of small molecules to monitor and perturb the activity of the human proteasome. Future Med Chem. 2021 01; 13(2):99-116. Maresh ME, Salazar-Chaparro AF, Trader DJ. PMID: 33275045; PMCID: PMC7857359.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    15. Fluorescent Probes with Unnatural Amino Acids to Monitor Proteasome Activity in Real-Time. ACS Chem Biol. 2020 09 18; 15(9):2588-2596. Zerfas BL, Coleman RA, Salazar-Chaparro AF, Macatangay NJ, Trader DJ. PMID: 32786259; PMCID: PMC8319958.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    16. Designing Chimeric Molecules for Drug Discovery by Leveraging Chemical Biology. J Med Chem. 2020 03 12; 63(5):1908-1928. Borsari C, Trader DJ, Tait A, Costi MP. PMID: 32023055; PMCID: PMC7997565.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    17. Discovery of a Small Molecule Probe of Rpn-6, an Essential Subunit of the 26S Proteasome. ACS Chem Biol. 2020 02 21; 15(2):554-561. Tian W, Trader DJ. PMID: 31877015.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    18. Synthesis and Application of an Activity-Based Peptide-Peptoid Hybrid Probe for the Immunoproteasome. Curr Protoc Chem Biol. 2019 12; 11(4):e76. Zerfas BL, Trader DJ. PMID: 31860787; PMCID: PMC6927525.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    19. The Immunoproteasome: An Emerging Target in Cancer and Autoimmune and Neurological Disorders. J Med Chem. 2020 03 12; 63(5):1841-1858. Zerfas BL, Maresh ME, Trader DJ. PMID: 31670954.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    20. Methods to Discover and Evaluate Proteasome Small Molecule Stimulators. Molecules. 2019 Jun 25; 24(12). Coleman RA, Trader DJ. PMID: 31242677; PMCID: PMC6630500.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    21. Small-Molecule Inhibitors of the Proteasome's Regulatory Particle. Chembiochem. 2019 07 15; 20(14):1739-1753. Muli CS, Tian W, Trader DJ. PMID: 30740849; PMCID: PMC6765334.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    22. Monitoring the Immunoproteasome in Live Cells Using an Activity-Based Peptide-Peptoid Hybrid Probe. J Am Chem Soc. 2019 04 03; 141(13):5252-5260. Zerfas BL, Trader DJ. PMID: 30862160; PMCID: PMC7389183.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    23. Development of a Method To Prioritize Protein-Ligand Pairs on Beads Using Protein Conjugated to a Near-IR Dye. ACS Comb Sci. 2019 03 11; 21(3):223-228. Maresh ME, Trader DJ. PMID: 30677288.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    24. Rubiscolins are naturally occurring G protein-biased delta opioid receptor peptides. Eur Neuropsychopharmacol. 2019 03; 29(3):450-456. Cassell RJ, Mores KL, Zerfas BL, Mahmoud AH, Lill MA, Trader DJ, van Rijn RM. PMID: 30591345; PMCID: PMC6421079.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    25. Analysis of chain length, substitution patterns, and unsaturation of AM-404 derivatives as 20S proteasome stimulators. Bioorg Med Chem Lett. 2019 02 01; 29(3):420-423. Coleman RA, Muli CS, Zhao Y, Bhardwaj A, Newhouse TR, Trader DJ. PMID: 30587447; PMCID: PMC6348054.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    26. All About the Core: A Therapeutic Strategy to Prevent Protein Accumulation with Proteasome Core Particle Stimulators. ACS Pharmacol Transl Sci. 2018 Nov 09; 1(2):140-142. Coleman RA, Trader DJ. PMID: 32219211; PMCID: PMC7088911.
      View in: PubMed   Mentions: 10  
    27. A Sensitive High-Throughput Screening Method for Identifying Small Molecule Stimulators of the Core Particle of the Proteasome. Curr Protoc Chem Biol. 2018 12; 10(4):e52. Coleman RA, Trader DJ. PMID: 30285317; PMCID: PMC6263736.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    28. Development and Application of a Sensitive Peptide Reporter to Discover 20S Proteasome Stimulators. ACS Comb Sci. 2018 05 14; 20(5):269-276. Coleman RA, Trader DJ. PMID: 29553711.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    29. Establishment of a suite of assays that support the discovery of proteasome stimulators. Biochim Biophys Acta Gen Subj. 2017 Apr; 1861(4):892-899. Trader DJ, Simanski S, Dickson P, Kodadek T. PMID: 28065760; PMCID: PMC5366797.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    30. Chemoselective enrichment as a tool to increase access to bioactive natural products: Case study borrelidin. Bioorg Med Chem Lett. 2015 Nov 01; 25(21):4767-4769. Trader DJ, Carlson EE. PMID: 26255540.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    31. A reversible and highly selective inhibitor of the proteasomal ubiquitin receptor rpn13 is toxic to multiple myeloma cells. J Am Chem Soc. 2015 May 20; 137(19):6312-9. Trader DJ, Simanski S, Kodadek T. PMID: 25914958; PMCID: PMC4455945.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    32. Integrated metabolomics approach facilitates discovery of an unpredicted natural product suite from Streptomyces coelicolor M145. ACS Chem Biol. 2013 Sep 20; 8(9):2009-16. Sidebottom AM, Johnson AR, Karty JA, Trader DJ, Carlson EE. PMID: 23777274; PMCID: PMC3783606.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    33. Taming of a superbase for selective phenol desilylation and natural product isolation. J Org Chem. 2013 Jul 19; 78(14):7349-55. Trader DJ, Carlson EE. PMID: 23815363.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    34. Chemoselective hydroxyl group transformation: an elusive target. Mol Biosyst. 2012 Oct; 8(10):2484-93. Trader DJ, Carlson EE. PMID: 22695722; PMCID: PMC3430791.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    35. Siloxyl ether functionalized resins for chemoselective enrichment of carboxylic acids. Org Lett. 2011 Oct 21; 13(20):5652-5. Trader DJ, Carlson EE. PMID: 21957886; PMCID: PMC3215773.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    36. Chemoselective enrichment for natural products discovery. Chem Sci. 2011 Apr 01; 2(4):760-764. Odendaal AY, Trader DJ, Carlson EE. PMID: 24926410; PMCID: PMC4051302.
      View in: PubMed   Mentions: 13  
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