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Tarnawski, Andrzej

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentMedicine
Address1001 Health Sciences Road
CA 92697-3950
Phone(562) 494-5493
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ahluwalia A, Brzozowska IM, Hoa N, Jones MK, Tarnawski A. Melatonin signaling in mitochondria extends beyond neurons and neuroprotection: Implications for angiogenesis and cardio/gastroprotection. Proc Natl Acad Sci U S A. 2018 Feb 27; 115(9):E1942-E1943. PMID: 29440384.
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    2. Ahluwalia A, Jones MK, Brzozowska I, Tarnawski A. In vitro model of vasculo-angiogenesis: demonstration that bone marrow derived endothelial progenitor cells form new hybrid capillary blood vessels jointly with gastric endothelial cells. J Physiol Pharmacol. 2017 Dec; 68(6):841-846. PMID: 29550796.
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    3. Ahluwalia A, Jones MK, Hoa N, Tarnawski A. NGF protects endothelial cells from indomethacin-induced injury through activation of mitochondria and upregulation of IGF-1. Cell Signal. 2017 Dec; 40:22-29. PMID: 28843696.
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    4. Ahluwalia A, Brzozowski T, Jones MK, Ichikawa Y, Tarnawski A. Formation of new blood vessels during gastric ulcer healing. Role of bone marrow derived endothelial progenitor cells. J Physiol Pharmacol. 2017 Aug; 68(4):585-589. PMID: 29151075.
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    5. Tarnawski A, Ahluwalia A, Jones MK, Brzozowski T. Expression of nerve growth factor in rat stomach. Implications for interactions between endothelial, neural and epithelial cells. J Physiol Pharmacol. 2016 Dec; 67(6):879-883. PMID: 28195068.
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    6. Ahluwalia A, Jones MK, Brzozowski T, Tarnawski A. Nerve growth factor is critical requirement for in vitro angiogenesis in gastric endothelial cells. Am J Physiol Gastrointest Liver Physiol. 2016 Nov 01; 311(5):G981-G987. PMID: 27742705.
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    7. Samarasena JB, Ahluwalia A, Shinoura S, Choi KD, Lee JG, Chang KJ, Tarnawski A. In vivo imaging of porcine gastric enteric nervous system using confocal laser endomicroscopy &molecular neuronal probe. J Gastroenterol Hepatol. 2016 Apr; 31(4):802-7. PMID: 26482711.
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    8. Samarasena JB, Tarnawski A, Ahluwalia A, Shinoura S, Choi KD, Lee JG, Chang KJ. EUS-guided in vivo imaging of the porcine esophageal enteric nervous system by using needle-based confocal laser endomicroscopy. Gastrointest Endosc. 2015 Dec; 82(6):1116-20. PMID: 26318831.
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    9. Tanigawa T, Ahluwalia A, Watanabe T, Arakawa T, Tarnawski A. Nerve growth factor injected into the gastric ulcer base incorporates into endothelial, neuronal, glial and epithelial cells: implications for angiogenesis, mucosal regeneration and ulcer healing. J Physiol Pharmacol. 2015 Aug; 66(4):617-21. PMID: 26348086.
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    10. Samarasena JB, Ahluwalia A, Tarnawski A, Shinoura S, Choi KD, Lee JG, Chang KJ. Expression of nerve growth factor, its TrkA receptor, and several neuropeptides in porcine esophagus. Implications for interactions between neural, vascular and epithelial components of the esophagus. J Physiol Pharmacol. 2015 Jun; 66(3):415-20. PMID: 26084223.
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    11. Tolstanova G, Deng X, Ahluwalia A, Paunovic B, Prysiazhniuk A, Ostapchenko L, Tarnawski A, Sandor Z, Szabo S. Role of Dopamine and D2 Dopamine Receptor in the Pathogenesis of Inflammatory Bowel Disease. Dig Dis Sci. 2015 Oct; 60(10):2963-75. PMID: 25972152.
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    12. Macé V, Ahluwalia A, Coron E, Le Rhun M, Boureille A, Bossard C, Mosnier JF, Matysiak-Budnik T, Tarnawski A. Confocal laser endomicroscopy: a new gold standard for the assessment of mucosal healing in ulcerative colitis. J Gastroenterol Hepatol. 2015 Mar; 30 Suppl 1:85-92. PMID: 25827810.
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    13. Tarnawski A, Ahluwalia A, Jones MK. Angiogenesis in gastric mucosa: an important component of gastric erosion and ulcer healing and its impairment in aging. J Gastroenterol Hepatol. 2014 Dec; 29 Suppl 4:112-23. PMID: 25521743.
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    14. Ahluwalia A, Baatar D, Jones MK, Tarnawski A. Novel mechanisms and signaling pathways of esophageal ulcer healing: the role of prostaglandin EP2 receptors, cAMP, and pCREB. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 15; 307(6):G602-10. PMID: 25059824; PMCID: PMC4166721.
    15. Tarnawski A, Ahluwalia A, Jones MK. Increased susceptibility of aging gastric mucosa to injury: the mechanisms and clinical implications. World J Gastroenterol. 2014 Apr 28; 20(16):4467-82. PMID: 24782600; PMCID: PMC4000484.
    16. Ahluwalia A, Jones MK, Szabo S, Tarnawski A. Aging impairs transcriptional regulation of vascular endothelial growth factor in human microvascular endothelial cells: implications for angiogenesis and cell survival. J Physiol Pharmacol. 2014 Apr; 65(2):209-15. PMID: 24781730.
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    17. Khomenko T, Deng X, Ahluwalia A, Tarnawski A, Patel KN, Sandor Z, Szabo S. STAT3 and importins are novel mediators of early molecular and cellular responses in experimental duodenal ulceration. Dig Dis Sci. 2014 Feb; 59(2):297-306. PMID: 24385009.
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    18. Ahluwalia A, Jones MK, Matysiak-Budnik T, Tarnawski A. VEGF and colon cancer growth beyond angiogenesis: does VEGF directly mediate colon cancer growth via a non-angiogenic mechanism? Curr Pharm Des. 2014; 20(7):1041-4. PMID: 23755727.
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    19. Ahluwalia A, Jones MK, Tarnawski A. Key role of endothelial importin-a in VEGF expression and gastric angiogenesis: novel insight into aging gastropathy. Am J Physiol Gastrointest Liver Physiol. 2014 Feb 15; 306(4):G338-45. PMID: 24356884.
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    20. Ahluwalia A, Jones MK, Szabo S, Tarnawski A. Aberrant, ectopic expression of VEGF and VEGF receptors 1 and 2 in malignant colonic epithelial cells. Implications for these cells growth via an autocrine mechanism. Biochem Biophys Res Commun. 2013 Aug 09; 437(4):515-20. PMID: 23831629.
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    21. Ahluwalia A, Jones MK, Deng X, Sandor Z, Szabo S, Tarnawski A. An imbalance between VEGF and endostatin underlies impaired angiogenesis in gastric mucosa of aging rats. Am J Physiol Gastrointest Liver Physiol. 2013 Aug 15; 305(4):G325-32. PMID: 23788612.
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    22. Tarnawski A, Ahluwalia A, Jones MK. Gastric cytoprotection beyond prostaglandins: cellular and molecular mechanisms of gastroprotective and ulcer healing actions of antacids. Curr Pharm Des. 2013; 19(1):126-32. PMID: 22950493.
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    23. Nakai Y, Shinoura S, Ahluwalia A, Tarnawski A, Chang KJ. In vivo visualization of epidermal growth factor receptor and survivin expression in porcine pancreas using endoscopic ultrasound guided fine needle imaging with confocal laser-induced endomicroscopy. J Physiol Pharmacol. 2012 Dec; 63(6):577-80. PMID: 23388473.
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    24. Nakai Y, Shinoura S, Ahluwalia A, Tarnawski A, Chang KJ. Molecular imaging of epidermal growth factor-receptor and survivin in vivo in porcine esophageal and gastric mucosae using probe-based confocal laser-induced endomicroscopy: proof of concept. J Physiol Pharmacol. 2012 Jun; 63(3):303-7. PMID: 22791645.
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    25. Ahluwalia A, Tarnawski A. Cathelicidin gene therapy: a new therapeutic option in ulcerative colitis and beyond? Gene Ther. 2013 Feb; 20(2):119-20. PMID: 22456327.
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    26. Coron E, Mosnier JF, Ahluwalia A, Le Rhun M, Galmiche JP, Tarnawski A, Matysiak-Budnik T. Colonic mucosal biopsies obtained during confocal endomicroscopy are pre-stained with fluorescein in vivo and are suitable for histologic evaluation. Endoscopy. 2012 Feb; 44(2):148-53. PMID: 22271025.
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    27. Tarnawski A, Ahluwalia A. Molecular mechanisms of epithelial regeneration and neovascularization during healing of gastric and esophageal ulcers. Curr Med Chem. 2012; 19(1):16-27. PMID: 22300072.
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    28. Tarnawski A, Ahluwalia A, Jones MK. The mechanisms of gastric mucosal injury: focus on microvascular endothelium as a key target. Curr Med Chem. 2012; 19(1):4-15. PMID: 22300071.
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    29. Ahluwalia A, Tarnawski A. Critical role of hypoxia sensor--HIF-1a in VEGF gene activation. Implications for angiogenesis and tissue injury healing. Curr Med Chem. 2012; 19(1):90-7. PMID: 22300081.
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    30. Ahluwalia A, Tarnawski A. Activation of the metabolic sensor-AMP activated protein kinase reverses impairment of angiogenesis in aging myocardial microvascular endothelial cells. Implications for the aging heart. J Physiol Pharmacol. 2011 Oct; 62(5):583-7. PMID: 22204807.
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    31. Tolstanova G, Deng X, French SW, Lungo W, Paunovic B, Khomenko T, Ahluwalia A, Kaplan T, Dacosta-Iyer M, Tarnawski A, Szabo S, Sandor Z. Early endothelial damage and increased colonic vascular permeability in the development of experimental ulcerative colitis in rats and mice. Lab Invest. 2012 Jan; 92(1):9-21. PMID: 21894149.
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    32. Paunovic B, Deng X, Khomenko T, Ahluwalia A, Tolstanova G, Tarnawski A, Szabo S, Sandor Z. Molecular mechanisms of basic fibroblast growth factor effect on healing of ulcerative colitis in rats. J Pharmacol Exp Ther. 2011 Nov; 339(2):430-7. PMID: 21841041.
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    33. Florkiewicz RZ, Ahluwalia A, Sandor Z, Szabo S, Tarnawski A. Gastric mucosal injury activates bFGF gene expression and triggers preferential translation of high molecular weight bFGF isoforms through CUG-initiated, non-canonical codons. Biochem Biophys Res Commun. 2011 Jun 10; 409(3):494-9. PMID: 21600881.
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    34. Deng X, Szabo S, Chen L, Paunovic B, Khomenko T, Tolstanova G, Tarnawski A, Jones MK, Sandor Z. New cell therapy using bone marrow-derived stem cells/endothelial progenitor cells to accelerate neovascularization in healing of experimental ulcerative colitis. Curr Pharm Des. 2011; 17(16):1643-51. PMID: 21548863.
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    35. Ahluwalia A, Narula J, Jones MK, Deng X, Tarnawski A. Impaired angiogenesis in aging myocardial microvascular endothelial cells is associated with reduced importin alpha and decreased nuclear transport of HIF1 alpha: mechanistic implications. J Physiol Pharmacol. 2010 Apr; 61(2):133-9. PMID: 20436213.
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    36. Tarnawski A, Pai R, Tanigawa T, Matysiak-Budnik T, Ahluwalia A. PTEN silencing reverses aging-related impairment of angiogenesis in microvascular endothelial cells. Biochem Biophys Res Commun. 2010 Apr 02; 394(2):291-6. PMID: 20193662.
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    37. Deng X, Tolstanova G, Khomenko T, Chen L, Tarnawski A, Szabo S, Sandor Z. Mesalamine restores angiogenic balance in experimental ulcerative colitis by reducing expression of endostatin and angiostatin: novel molecular mechanism for therapeutic action of mesalamine. J Pharmacol Exp Ther. 2009 Dec; 331(3):1071-8. PMID: 19762547.
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    38. Ahluwalia A, Li A, Cheng G, Deng X, Tarnawski A. Reduced ghrelin in endothelial cells plays important mechanistic role in aging-related impairment of angiogenesis. J Physiol Pharmacol. 2009 Jun; 60(2):29-34. PMID: 19617642.
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    39. Tanigawa T, Watanabe T, Higuchi K, Tominaga K, Fujiwara Y, Oshitani N, Tarnawski A, Arakawa T. Long-term use of nonsteroidal anti-inflammatory drugs normalizes the kinetics of gastric epithelial cells in patients with Helicobacter pylori infection via attenuation of gastric mucosal inflammation. J Gastroenterol. 2009; 44 Suppl 19:8-17. PMID: 19148787.
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    40. Tolstanova G, Khomenko T, Deng X, Chen L, Tarnawski A, Ahluwalia A, Szabo S, Sandor Z. Neutralizing anti-vascular endothelial growth factor (VEGF) antibody reduces severity of experimental ulcerative colitis in rats: direct evidence for the pathogenic role of VEGF. J Pharmacol Exp Ther. 2009 Mar; 328(3):749-57. PMID: 19060224.
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    41. Kinjo N, Kawanaka H, Akahoshi T, Yamaguchi S, Yoshida D, Anegawa G, Konishi K, Tomikawa M, Tanoue K, Tarnawski A, Hashizume M, Maehara Y. Significance of ERK nitration in portal hypertensive gastropathy and its therapeutic implications. Am J Physiol Gastrointest Liver Physiol. 2008 Nov; 295(5):G1016-24. PMID: 18787063.
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    42. Laine L, Takeuchi K, Tarnawski A. Gastric mucosal defense and cytoprotection: bench to bedside. Gastroenterology. 2008 Jul; 135(1):41-60. PMID: 18549814.
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    43. Tarnawski A, Pai R, Deng X, Ahluwalia A, Khomenko T, Tanigawa T, Akahoshi T, Sandor Z, Szabo S. Aging gastropathy-novel mechanisms: hypoxia, up-regulation of multifunctional phosphatase PTEN, and proapoptotic factors. Gastroenterology. 2007 Dec; 133(6):1938-47. PMID: 18054565.
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    44. Chu EC, Chai J, Ahluwalia A, Tarnawski A. Mesalazine downregulates c-Myc in human colon cancer cells. A key to its chemopreventive action? Aliment Pharmacol Ther. 2007 Jun 15; 25(12):1443-9. PMID: 17539984.
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    45. Chu EC, Tarnawski A. Rapid colonoscopic detection and quantification of colonic ischemia by using a laser Doppler flowmeter. Gastrointest Endosc. 2007 Sep; 66(3):630-2. PMID: 17521646.
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    46. Nguyen T, Chai J, Li A, Akahoshi T, Tanigawa T, Tarnawski A. Novel roles of local insulin-like growth factor-1 activation in gastric ulcer healing: promotes actin polymerization, cell proliferation, re-epithelialization, and induces cyclooxygenase-2 in a phosphatidylinositol 3-kinase-dependent manner. Am J Pathol. 2007 Apr; 170(4):1219-28. PMID: 17392162; PMCID: PMC1829456.
    47. Phan E, Ahluwalia A, Tarnawski A. Role of SPARC--matricellular protein in pathophysiology and tissue injury healing. Implications for gastritis and gastric ulcers. Med Sci Monit. 2007 Feb; 13(2):RA25-30. PMID: 17261993.
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    48. Tanigawa T, Pai R, Arakawa T, Tarnawski A. Rebamipide inhibits gastric cancer cell growth. Dig Dis Sci. 2007 Jan; 52(1):240-7. PMID: 17171453.
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    49. Mandayam S, Huang R, Tarnawski A, Chiou SK. Roles of survivin isoforms in the chemopreventive actions of NSAIDS on colon cancer cells. Apoptosis. 2007 Jun; 12(6):1109-16. PMID: 17151952.
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    50. Li A, Cheng G, Zhu GH, Tarnawski A. Ghrelin stimulates angiogenesis in human microvascular endothelial cells: Implications beyond GH release. Biochem Biophys Res Commun. 2007 Feb 09; 353(2):238-43. PMID: 17184731.
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    51. Huang RH, Chai J, Tarnawski A. Identification of specific genes and pathways involved in NSAIDs-induced apoptosis of human colon cancer cells. World J Gastroenterol. 2006 Oct 28; 12(40):6446-52. PMID: 17072976; PMCID: PMC4100633.
    52. Chai J, Norng M, Tarnawski A, Chow J. A critical role of serum response factor in myofibroblast differentiation during experimental oesophageal ulcer healing in rats. Gut. 2007 May; 56(5):621-30. PMID: 17068115; PMCID: PMC1942159.
    53. Sandor Z, Deng XM, Khomenko T, Tarnawski A, Szabo S. Altered angiogenic balance in ulcerative colitis: a key to impaired healing? Biochem Biophys Res Commun. 2006 Nov 10; 350(1):147-50. PMID: 17011522.
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    54. Moon WS, Park HS, Yu KH, Jang KY, Kang MJ, Park H, Tarnawski A. Expression of angiopoietin 1, 2 and their common receptor Tie2 in human gastric carcinoma: implication for angiogenesis. J Korean Med Sci. 2006 Apr; 21(2):272-8. PMID: 16614513; PMCID: PMC2734003.
    55. Tarnawski A. Gene therapy for ulcerations of the gastrointestinal tract. Drugs Today (Barc). 2006 Mar; 42(3):193-203. PMID: 16628261.
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    56. Tarnawski A. Cellular and molecular mechanisms of gastrointestinal ulcer healing. Dig Dis Sci. 2005 Oct; 50 Suppl 1:S24-33. PMID: 16184417.
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    57. Arakawa T, Higuchi K, Fujiwara Y, Watanabe T, Tominaga K, Sasaki E, Oshitani N, Yoshikawa T, Tarnawski A. 15th anniversary of rebamipide: looking ahead to the new mechanisms and new applications. Dig Dis Sci. 2005 Oct; 50 Suppl 1:S3-S11. PMID: 16184418.
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    58. Moon WS, Park HS, Lee H, Pai R, Tarnawski A, Kim KR, Jang KY. Co-expression of cox-2, C-met and beta-catenin in cells forming invasive front of gallbladder cancer. Cancer Res Treat. 2005 Jun; 37(3):171-6. PMID: 19956499; PMCID: PMC2785404.
    59. Pai R, Lin C, Tran T, Tarnawski A. Leptin activates STAT and ERK2 pathways and induces gastric cancer cell proliferation. Biochem Biophys Res Commun. 2005 Jun 17; 331(4):984-92. PMID: 15882975.
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    60. Tanigawa T, Pai R, Arakawa T, Higuchi K, Tarnawski A. TGF-beta signaling pathway: its role in gastrointestinal pathophysiology and modulation of ulcer healing. J Physiol Pharmacol. 2005 Mar; 56(1):3-13. PMID: 15795471.
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    61. Moon WS, Tarnawski A, Chai J, Yang JT, Majumdar AP. Reduced expression of epidermal growth factor receptor related protein in gastric cancer. Gut. 2005 Feb; 54(2):201-6. PMID: 15647181; PMCID: PMC1774858.
    62. Chiou SK, Tanigawa T, Akahoshi T, Abdelkarim B, Jones MK, Tarnawski A. Survivin: a novel target for indomethacin-induced gastric injury. Gastroenterology. 2005 Jan; 128(1):63-73. PMID: 15633124.
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    63. Chu EC, Tarnawski A. PTEN regulatory functions in tumor suppression and cell biology. Med Sci Monit. 2004 Oct; 10(10):RA235-41. PMID: 15448614.
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    64. Chu EC, Chai J, Tarnawski A. NSAIDs activate PTEN and other phosphatases in human colon cancer cells: novel mechanism for chemopreventive action of NSAIDs. Biochem Biophys Res Commun. 2004 Jul 30; 320(3):875-9. PMID: 15240129.
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    65. Tarnawski A, Caves TC. Aspirin in the XXI century: its major clinical impact, novel mechanisms of action, and new safer formulations. Gastroenterology. 2004 Jul; 127(1):341-3. PMID: 15236206.
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    66. Moon WS, Chang KJ, Majumdar AP, Tarnawski A. Reduced expression of epidermal growth factor receptor-related protein in hepatocellular carcinoma: implications for cancer growth. Digestion. 2004; 69(4):219-24. PMID: 15205570.
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    67. Chai J, Jones MK, Tarnawski A. Serum response factor is a critical requirement for VEGF signaling in endothelial cells and VEGF-induced angiogenesis. FASEB J. 2004 Aug; 18(11):1264-6. PMID: 15180964.
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    68. Chai J, Baatar D, Tarnawski A. Serum response factor promotes re-epithelialization and muscular structure restoration during gastric ulcer healing. Gastroenterology. 2004 Jun; 126(7):1809-18. PMID: 15188176.
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    69. Jones MK, Tsugawa K, Tarnawski A, Baatar D. Dual actions of nitric oxide on angiogenesis: possible roles of PKC, ERK, and AP-1. Biochem Biophys Res Commun. 2004 May 28; 318(2):520-8. PMID: 15120632.
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    70. Khomenko T, Deng X, Sandor Z, Tarnawski A, Szabo S. Cysteamine alters redox state, HIF-1alpha transcriptional interactions and reduces duodenal mucosal oxygenation: novel insight into the mechanisms of duodenal ulceration. Biochem Biophys Res Commun. 2004 Apr 23; 317(1):121-7. PMID: 15047156.
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    71. Moon WS, Chang K, Tarnawski A. Overexpression of metastatic tumor antigen 1 in hepatocellular carcinoma: Relationship to vascular invasion and estrogen receptor-alpha. Hum Pathol. 2004 Apr; 35(4):424-9. PMID: 15116322.
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    72. Pai R, Tarnawski A, Tran T. Deoxycholic acid activates beta-catenin signaling pathway and increases colon cell cancer growth and invasiveness. Mol Biol Cell. 2004 May; 15(5):2156-63. PMID: 15004225; PMCID: PMC404012.
    73. Tarnawski A, Chai J, Pai R, Chiou SK. Rebamipide activates genes encoding angiogenic growth factors and Cox2 and stimulates angiogenesis: a key to its ulcer healing action? Dig Dis Sci. 2004 Feb; 49(2):202-9. PMID: 15104358.
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    74. Sasaki E, Tominaga K, Watanabe T, Fujiwara Y, Oshitani N, Matsumoto T, Higuchi K, Tarnawski A, Arakawa T. COX-2 is essential for EGF induction of cell proliferation in gastric RGM1 cells. Dig Dis Sci. 2003 Dec; 48(12):2257-62. PMID: 14714610.
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    75. Tabel G, Hoa NT, Tarnawski A, Chen J, Domek M, Ma TY. Helicobacter pylori infection inhibits healing of the wounded duodenal epithelium in vitro. J Lab Clin Med. 2003 Dec; 142(6):421-30. PMID: 14713894.
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    76. Moon WS, Tarnawski A. Nuclear translocation of survivin in hepatocellular carcinoma: a key to cancer cell growth? Hum Pathol. 2003 Nov; 34(11):1119-26. PMID: 14652813.
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    77. Tsugawa K, Jones MK, Akahoshi T, Moon WS, Maehara Y, Hashizume M, Sarfeh IJ, Tarnawski A. Abnormal PTEN expression in portal hypertensive gastric mucosa: a key to impaired PI 3-kinase/Akt activation and delayed injury healing? FASEB J. 2003 Dec; 17(15):2316-8. PMID: 14525948.
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    78. Tarnawski A, Jones MK. Inhibition of angiogenesis by NSAIDs: molecular mechanisms and clinical implications. J Mol Med (Berl). 2003 Oct; 81(10):627-36. PMID: 13679997.
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    79. Pai R, Nakamura T, Moon WS, Tarnawski A. Prostaglandins promote colon cancer cell invasion; signaling by cross-talk between two distinct growth factor receptors. FASEB J. 2003 Sep; 17(12):1640-7. PMID: 12958170.
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    80. Moon WS, Rhyu KH, Kang MJ, Lee DG, Yu HC, Yeum JH, Koh GY, Tarnawski A. Overexpression of VEGF and angiopoietin 2: a key to high vascularity of hepatocellular carcinoma? Mod Pathol. 2003 Jun; 16(6):552-7. PMID: 12808060.
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    81. Chiou SK, Moon WS, Jones MK, Tarnawski A. Survivin expression in the stomach: implications for mucosal integrity and protection. Biochem Biophys Res Commun. 2003 May 30; 305(2):374-9. PMID: 12745085.
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    82. Chiou SK, Jones MK, Tarnawski A. Survivin - an anti-apoptosis protein: its biological roles and implications for cancer and beyond. Med Sci Monit. 2003 Apr; 9(4):PI25-9. PMID: 12709681.
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    83. Netzer P, Halter F, Ma TY, Hoa N, Nguyen N, Nakamura T, Tarnawski A. Interaction of hepatocyte growth factor and non-steroidal anti-inflammatory drugs during gastric epithelial wound healing. Digestion. 2003; 67(3):118-28. PMID: 12853723.
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    84. Baatar D, Jones MK, Tsugawa K, Pai R, Moon WS, Koh GY, Kim I, Kitano S, Tarnawski A. Esophageal ulceration triggers expression of hypoxia-inducible factor-1 alpha and activates vascular endothelial growth factor gene: implications for angiogenesis and ulcer healing. Am J Pathol. 2002 Oct; 161(4):1449-57. PMID: 12368217; PMCID: PMC1867290.
    85. Szabó IL, Pai R, Jones MK, Ehring GR, Kawanaka H, Tarnawski A. Indomethacin delays gastric restitution: association with the inhibition of focal adhesion kinase and tensin phosphorylation and reduced actin stress fibers. Exp Biol Med (Maywood). 2002 Jun; 227(6):412-24. PMID: 12037131.
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    86. Chai J, Tarnawski A. Serum response factor: discovery, biochemistry, biological roles and implications for tissue injury healing. J Physiol Pharmacol. 2002 Jun; 53(2):147-57. PMID: 12120892.
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    87. Mohajer B, Tarnawski A, Hoa NT, Tran D, Chen J, Park H, Ma TY. Low dose ethanol potentiates indomethacin induced inhibition of wound re-epithelialization in duodenal monolayers. Life Sci. 2002 May 17; 70(26):3143-53. PMID: 12008097.
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    88. Giap AQ, Tarnawski A, Hoa NT, Akotia V, Ma TY. NSAID inhibition of RGM1 gastric monolayer wound re-epithelialization: comparison of selective Cox-2 versus non-selective Cox inhibitors. Life Sci. 2002 May 10; 70(25):3029-37. PMID: 12138016.
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    89. Tsugawa K, Jones MK, Sugimachi K, Sarfeh IJ, Tarnawski A. Biological role of phosphatase PTEN in cancer and tissue injury healing. Front Biosci. 2002 May 01; 7:e245-51. PMID: 11991859.
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    90. Pai R, Soreghan B, Szabo IL, Pavelka M, Baatar D, Tarnawski A. Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy. Nat Med. 2002 Mar; 8(3):289-93. PMID: 11875501.
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    91. Baatar D, Jones MK, Pai R, Kawanaka H, Szabo IL, Moon WS, Kitano S, Tarnawski A. Selective cyclooxygenase-2 blocker delays healing of esophageal ulcers in rats and inhibits ulceration-triggered c-Met/hepatocyte growth factor receptor induction and extracellular signal-regulated kinase 2 activation. Am J Pathol. 2002 Mar; 160(3):963-72. PMID: 11891194; PMCID: PMC1867196.
    92. Kawanaka H, Jones MK, Szabo IL, Baatar D, Pai R, Tsugawa K, Sugimachi K, Sarfeh IJ, Tarnawski A. Activation of eNOS in rat portal hypertensive gastric mucosa is mediated by TNF-alpha via the PI 3-kinase-Akt signaling pathway. Hepatology. 2002 Feb; 35(2):393-402. PMID: 11826414.
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    93. Baatar D, Kawanaka H, Szabo IL, Pai R, Jones MK, Kitano S, Tarnawski A. Esophageal ulceration activates keratinocyte growth factor and its receptor in rats: implications for ulcer healing. Gastroenterology. 2002 Feb; 122(2):458-68. PMID: 11832460.
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    94. Jones MK, Szabó IL, Kawanaka H, Husain SS, Tarnawski A. von Hippel Lindau tumor suppressor and HIF-1alpha: new targets of NSAIDs inhibition of hypoxia-induced angiogenesis. FASEB J. 2002 Feb; 16(2):264-6. PMID: 11772947.
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    95. Pai R, Szabo IL, Giap AQ, Kawanaka H, Tarnawski A. Nonsteroidal anti-inflammatory drugs inhibit re-epithelialization of wounded gastric monolayers by interfering with actin, Src, FAK, and tensin signaling. Life Sci. 2001 Nov 09; 69(25-26):3055-71. PMID: 11758831.
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    96. Kawanaka H, Tomikawa M, Baatar D, Jones MK, Pai R, Szabo IL, Sugimachi K, Sarfeh IJ, Tarnawski A. Despite activation of EGF-receptor-ERK signaling pathway, epithelial proliferation is impaired in portal hypertensive gastric mucosa: relevance of MKP-1, c-fos, c-myc, and cyclin D1 expression. Life Sci. 2001 Nov 09; 69(25-26):3019-33. PMID: 11758828.
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    97. Szabo IL, Kawanaka H, Jones MK, Pai R, Soreghan BA, Baatar D, Husain SS, Tarnawski A. Activation of hypoxia inducible factor-1alpha in gastric mucosa in response to ethanol injury: a trigger for angiogenesis? Life Sci. 2001 Nov 09; 69(25-26):3035-44. PMID: 11758829.
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    98. Husain SS, Szabo IL, Pai R, Soreghan B, Jones MK, Tarnawski A. MAPK (ERK2) kinase--a key target for NSAIDs-induced inhibition of gastric cancer cell proliferation and growth. Life Sci. 2001 Nov 09; 69(25-26):3045-54. PMID: 11758830.
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    99. Jones MK, Kawanaka H, Baatar D, Szabó IL, Tsugawa K, Pai R, Koh GY, Kim I, Sarfeh IJ, Tarnawski A. Gene therapy for gastric ulcers with single local injection of naked DNA encoding VEGF and angiopoietin-1. Gastroenterology. 2001 Nov; 121(5):1040-7. PMID: 11677194.
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    100. Kawanaka H, Tomikawa M, Jones MK, Szabo IL, Pai R, Baatar D, Tsugawa K, Sugimachi K, Sarfeh IJ, Tarnawski A. Defective mitogen-activated protein kinase (ERK2) signaling in gastric mucosa of portal hypertensive rats: potential therapeutic implications. Hepatology. 2001 Nov; 34(5):990-9. PMID: 11679970.
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    101. Pai R, Szabo IL, Soreghan BA, Atay S, Kawanaka H, Tarnawski A. PGE(2) stimulates VEGF expression in endothelial cells via ERK2/JNK1 signaling pathways. Biochem Biophys Res Commun. 2001 Sep 07; 286(5):923-8. PMID: 11527387.
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    102. Halter F, Tarnawski A, Schmassmann A, Peskar BM. Cyclooxygenase 2-implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives. Gut. 2001 Sep; 49(3):443-53. PMID: 11511570; PMCID: PMC1728453.
    103. Kawanaka H, Tomikawa M, Jones MK, Pai R, Szabo IL, Sugimachi K, Sarfeh IJ, Tarnawski A. Portal hypertensive gastric mucosa has reduced activation of MAP kinase (ERK2) in response to alcohol injury: a key to impaired healing? FASEB J. 2001 Mar; 15(3):574-6. PMID: 11259371.
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    104. Tarnawski A, Szabo I. Apoptosis-programmed cell death and its relevance to gastrointestinal epithelium: survival signal from the matrix. Gastroenterology. 2001 Jan; 120(1):294-9. PMID: 11208739.
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    105. Szabó IL, Pai R, Soreghan B, Jones MK, Baatar D, Kawanaka H, Tarnawski A. NSAIDs inhibit the activation of egr-1 gene in microvascular endothelial cells. A key to inhibition of angiogenesis? J Physiol Paris. 2001 Jan-Dec; 95(1-6):379-83. PMID: 11595463.
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    106. Ehring GR, Szabó IL, Jones MK, Sarfeh IJ, Tarnawski A. ATP-induced CA2+-signaling enhances rat gastric microvascular endothelial cell migration. J Physiol Pharmacol. 2000 Dec; 51(4 Pt 2):799-811. PMID: 11220489.
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    107. Jones MK, Wang H, Tomikawa M, Szabó IL, Kawanaka H, Sarfeh IJ, Tarnawski A. Isolation and characterization of rat gastric microvascular endothelial cells as a model for studying gastric angiogenesis in vitro. J Physiol Pharmacol. 2000 Dec; 51(4 Pt 2):813-20. PMID: 11220490.
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    108. Tomikawa M, Akiba Y, Kaunitz JD, Kawanaka H, Sugimachi K, Sarfeh IJ, Tarnawski A. New insights into impairment of mucosal defense in portal hypertensive gastric mucosa. J Gastrointest Surg. 2000 Sep-Oct; 4(5):458-63. PMID: 11077319.
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    109. Pai R, Szabo IL, Kawanaka H, Soreghan BA, Jones MK, Tarnawski A. Indomethacin inhibits endothelial cell proliferation by suppressing cell cycle proteins and PRB phosphorylation: a key to its antiangiogenic action? Mol Cell Biol Res Commun. 2000 Aug; 4(2):111-6. PMID: 11170841.
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    110. Atay S, Tarnawski A, Dubois A. Eicosanoids and the stomach. Prostaglandins Other Lipid Mediat. 2000 May; 61(3-4):105-24. PMID: 10867124.
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    111. Tarnawski A, Tomikawa M, Ohta M, Sarfeh IJ. Antacid talcid activates in gastric mucosa genes encoding for EGF and its receptor. The molecular basis for its ulcer healing action. J Physiol Paris. 2000 Mar-Apr; 94(2):93-8. PMID: 10791688.
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    112. Szabó I, Tarnawski A. Apoptosis in the gastric mucosa: molecular mechanisms, basic and clinical implications. J Physiol Pharmacol. 2000 Mar; 51(1):3-15. PMID: 10768847.
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    113. Wang H, Tomikawa M, Jones MK, Pai R, Sarfeh IJ, Tarnawski A. Sequential expression of adrenomedullin and its receptor during gastric ulcer healing in rats. Dig Dis Sci. 2000 Mar; 45(3):591-8. PMID: 10749338.
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    114. Ohta M, Pai R, Kawanaka H, Ma T, Sugimachi K, Sarfeh IJ, Tarnawski A. Expression of endothelin-1, and endothelin A and B receptors in portal hypertensive esophagus of rats. J Physiol Pharmacol. 2000 Mar; 51(1):57-67. PMID: 10768851.
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    115. Tarnawski A, Arakawa T, Sekhon S, Ichikawa Y, Szabo I, Sarfeh IJ. Isolation of morphologically and functionally intact gastric mucosal microvessels rapid communication. J Physiol Pharmacol. 2000 Mar; 51(1):167-75. PMID: 10768860.
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    116. Pai R, Sasaki E, Tarnawski A. Helicobacter pylori vacuolating cytotoxin (VacA) alters cytoskeleton-associated proteins and interferes with re-epithelialization of wounded gastric epithelial monolayers. Cell Biol Int. 2000; 24(5):291-301. PMID: 10805963.
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    117. Jones MK, Sasaki E, Halter F, Pai R, Nakamura T, Arakawa T, Kuroki T, Tarnawski A. HGF triggers activation of the COX-2 gene in rat gastric epithelial cells: action mediated through the ERK2 signaling pathway. FASEB J. 1999 Dec; 13(15):2186-94. PMID: 10593866.
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    118. Jones MK, Wang H, Peskar BM, Levin E, Itani RM, Sarfeh IJ, Tarnawski A. Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. Nat Med. 1999 Dec; 5(12):1418-23. PMID: 10581086.
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    119. Pai R, Jones MK, Tomikawa M, Tarnawski A. Activation of Raf-1 during experimental gastric ulcer healing is Ras-mediated and protein kinase C-independent. Am J Pathol. 1999 Nov; 155(5):1759-66. PMID: 10550332; PMCID: PMC1866970.
    120. Ma TY, Kikuchi M, Sarfeh IJ, Shimada H, Hoa NT, Tarnawski A. Basic fibroblast growth factor stimulates repair of wounded hepatocyte monolayer: modulatory role of protein kinase A and extracellular matrix. J Lab Clin Med. 1999 Oct; 134(4):363-71. PMID: 10521082.
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    121. Pai R, Cover TL, Tarnawski A. Helicobacter pylori vacuolating cytotoxin (VacA) disorganizes the cytoskeletal architecture of gastric epithelial cells. Biochem Biophys Res Commun. 1999 Aug 19; 262(1):245-50. PMID: 10448099.
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    122. Wang H, Tomikawa M, Jones MK, Sarfeh IJ, Tarnawski A. Ethanol injury triggers activation of adrenomedullin and its receptor genes in gastric mucosa. Dig Dis Sci. 1999 Jul; 44(7):1390-400. PMID: 10489925.
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    123. Tomikawa M, Wang H, Jones MK, Sugimachi K, Sarfeh IJ, Tarnawski A. Reduced adrenomedullin expression in gastric mucosa of portal hypertensive rats after ethanol-induced injury. Ann Surg. 1999 Jul; 230(1):38-44. PMID: 10400034; PMCID: PMC1420842.
    124. Jones MK, Itani RM, Wang H, Tomikawa M, Sarfeh IJ, Szabo S, Tarnawski A. Activation of VEGF and Ras genes in gastric mucosa during angiogenic response to ethanol injury. Am J Physiol. 1999 Jun; 276(6 Pt 1):G1345-55. PMID: 10362637.
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    125. Jones MK, Tomikawa M, Mohajer B, Tarnawski A. Gastrointestinal mucosal regeneration: role of growth factors. Front Biosci. 1999 Mar 15; 4:D303-9. PMID: 10077540.
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    126. Tarnawski A, Pai R, Wang H, Tomikawa M. Translocation of MAP (Erk-1 and -2) kinases to cell nuclei and activation of c-fos gene during healing of experimental gastric ulcers. J Physiol Pharmacol. 1998 Dec; 49(4):479-88. PMID: 10069690.
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    127. Jones MK, Sarfeh IJ, Tarnawski A. Induction of in vitro angiogenesis in the endothelial-derived cell line, EA hy926, by ethanol is mediated through PKC and MAPK. Biochem Biophys Res Commun. 1998 Aug 10; 249(1):118-23. PMID: 9705842.
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    128. Pai R, Wyle FA, Cover TL, Itani RM, Domek MJ, Tarnawski A. Helicobacter pylori culture supernatant interferes with epidermal growth factor-activated signal transduction in human gastric KATO III cells. Am J Pathol. 1998 Jun; 152(6):1617-24. PMID: 9626065; PMCID: PMC1858446.
    129. Tomikawa M, Wang H, Jones MK, Sugimachi K, Sarfeh IJ, Tarnawski A. Expression of adrenomedullin in portal hypertensive gastric mucosa of rats. J Physiol Pharmacol. 1998 Jun; 49(2):319-28. PMID: 9670115.
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    130. Tomikawa M, Ohta M, Vaziri ND, Kaunitz JD, Itani R, Ni Z, Tarnawski A. Decreased endothelial nitric oxide synthase in gastric mucosa of rats with chronic renal failure. Am J Physiol. 1998 Jun; 274(6 Pt 2):F1102-8. PMID: 9841502.
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    131. Pai R, Ohta M, Itani RM, Sarfeh IJ, Tarnawski A. Induction of mitogen-activated protein kinase signal transduction pathway during gastric ulcer healing in rats. Gastroenterology. 1998 Apr; 114(4):706-13. PMID: 9516391.
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    132. Ohta M, Tarnawski A, Itani R, Pai R, Tomikawa M, Sugimachi K, Sarfeh IJ. Tumor necrosis factor alpha regulates nitric oxide synthase expression in portal hypertensive gastric mucosa of rats. Hepatology. 1998 Apr; 27(4):906-13. PMID: 9537427.
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    133. Sasaki E, Pai R, Halter F, Komurasaki T, Arakawa T, Kobayashi K, Kuroki T, Tarnawski A. Induction of cyclooxygenase-2 in a rat gastric epithelial cell line by epiregulin and basic fibroblast growth factor. J Clin Gastroenterol. 1998; 27 Suppl 1:S21-7. PMID: 9872494.
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    134. Tarnawski A, Jones MK. The role of epidermal growth factor (EGF) and its receptor in mucosal protection, adaptation to injury, and ulcer healing: involvement of EGF-R signal transduction pathways. J Clin Gastroenterol. 1998; 27 Suppl 1:S12-20. PMID: 9872493.
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    135. Ohta M, Nguyen TH, Tarnawski A, Pai R, Kratzberg YP, Sugimachi K, Sarfeh IJ. Overexpression of endothelin-1 mRNA and protein in portal hypertensive gastric mucosa of rats: a key to increased susceptibility to damage? Surgery. 1997 Nov; 122(5):936-42. PMID: 9369894.
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    136. Kaviani A, Ohta M, Itani R, Sander F, Tarnawski A, Sarfeh IJ. Tumor necrosis factor-alpha regulates inducible nitric oxide synthase gene expression in the portal hypertensive gastric mucosa of the rat. J Gastrointest Surg. 1997 Jul-Aug; 1(4):371-6. PMID: 9834372.
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    137. Ohta M, Tanoue K, Tarnawski A, Pai R, Itani RM, Sander FC, Sugimachi K, Sarfeh IJ. Overexpressed nitric oxide synthase in portal-hypertensive stomach of rat: a key to increased susceptibility to damage? Gastroenterology. 1997 Jun; 112(6):1920-30. PMID: 9178684.
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    138. Ohta M, Kaviani A, Tarnawski A, Itani R, Sugimachi K, Sarfeh IJ. Portal hypertension triggers local activation of inducible nitric oxide synthase gene in colonic mucosa. J Gastrointest Surg. 1997 May-Jun; 1(3):229-35. PMID: 9834352.
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    139. Kikuchi M, Ma TY, Tarnawski A, Shimada H, Sarfeh IJ. Role of protein kinase a pathway in epidermal growth factor-induced liver cell repair. J Gastrointest Surg. 1997 Mar-Apr; 1(2):132-7. PMID: 9834339.
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    140. Tanoue K, Tarnawski A, Santos AM, Hanke S, Sugimachi K, Sarfeh IJ. Reduced expression of basic fibroblast growth factor and its receptor mRNAs and proteins in portal hypertensive esophageal mucosa: a mechanism responsible for muscularis mucosae thinning and variceal rupture. Surgery. 1996 Apr; 119(4):424-30. PMID: 8644008.
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    141. Tanoue K, Ohta M, Tarnawski A, Wahlstrom KJ, Sugimachi K, Sarfeh IJ. Portal hypertension activates the nitric oxide synthase genes in the esophageal mucosa of rats. Gastroenterology. 1996 Feb; 110(2):549-57. PMID: 8566603.
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    142. Tanoue K, Tarnawski A, Kishihara F, Ohta M, Hashizume M, Sugimachi K, Sarfeh IJ. Effect of teprenone on portal hypertensive gastric mucosa. Digestion. 1996; 57(1):35-40. PMID: 8626046.
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    143. Erickson RA, Bezabah S, Jonas G, Lifrak E, Tarnawski A. Chronic omeprazole treatment increases duodenal susceptibility to ethanol injury in rats. Dig Dis Sci. 1991 Jul; 36(7):897-904. PMID: 2070702.
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    144. Tarnawski A, Sarfeh IJ, Stachura J, Hajduczek A, Bui HX, Dabros W, Gergely H. Microvascular abnormalities of the portal hypertensive gastric mucosa. Hepatology. 1988 Nov-Dec; 8(6):1488-94. PMID: 3192161.
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