Albert Russell La Spada

Title(s)Professor, Pathology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-7407
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    Engineered AAV vectors for combinatorial treatment of rare genetic brain diseases
    NIH R01FD007478Sep 1, 2021 - Aug 31, 2024
    Role: Co-Principal Investigator
    La Spada Outstanding Investigator Award
    NIH R35NS122140May 15, 2021 - Apr 30, 2029
    Role: Principal Investigator
    Ataxia Investigators Meeting 8: Leveraging Therapeutic Opportunity into Novel Treatment Paradigms
    NIH R13NS115342Mar 1, 2020 - Feb 28, 2021
    Role: Principal Investigator
    Enhanced skeletal muscle proteostasis as a determinant of CNS protein quality control and neural function in the aging brain
    NIH RF1AG057264Sep 15, 2017 - Jun 30, 2022
    Role: Principal Investigator
    Deconstructing the cellular and molecular basis of SBMA motor neuron disease: From mechanism to therapy
    NIH R01NS100023Sep 30, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Ataxin-7 oligonucleotide knock-down to treat SCA7 retinal and cerebellar disease
    NIH R01EY024747Aug 1, 2014 - Jul 31, 2018
    Role: Principal Investigator
    Antisense oligonucleotide knock-down of ataxin-7 in a SCA7 mouse model
    NIH R21NS082112Sep 30, 2012 - Aug 31, 2014
    Role: Principal Investigator
    Huntington's Disease Natural Product Drug Discovery
    NIH R21AG038772Sep 1, 2011 - Aug 31, 2015
    Role: Co-Principal Investigator
    Neuronal RNA processing defects in ALS4 caused by SETX mutations
    NIH R01GM094384Aug 1, 2010 - Jul 31, 2016
    Role: Co-Principal Investigator
    The PPAR-delta pathway in neural function and Huntington's disease neuropathology
    NIH R01NS065874Feb 1, 2010 - Jan 31, 2022
    Role: Principal Investigator
    Molecular genetic regulation of autophagy in health and neurodegenerative disease
    NIH R01AG033082Dec 1, 2008 - May 31, 2021
    Role: Principal Investigator
    Non-cell autonomous neurodegeneration in SCA7
    NIH R01NS052535Sep 15, 2008 - Aug 31, 2012
    Role: Co-Principal Investigator
    NIH R01EY014997Jul 1, 2003 - May 31, 2015
    Role: Principal Investigator
    SCA7 neurodegeneration: Molecular epigenetic basis and therapy
    NIH R01EY014061May 1, 2002 - Jun 30, 2023
    Role: Principal Investigator
    NIH R01NS041648Jun 1, 2001 - Aug 31, 2016
    Role: Principal Investigator
    CCCTC-binding factor (CTCF) in trinucleotide repeat instability and disease
    NIH R01GM059356May 1, 1999 - Jan 31, 2013
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. 4E-BP1 Protects Neurons from Misfolded Protein Stress and Parkinson's Disease Toxicity by Inducing the Mitochondrial Unfolded Protein Response. J Neurosci. 2020 11 04; 40(45):8734-8745. Dastidar SG, Pham MT, Mitchell MB, Yeom SG, Jordan S, Chang A, Sopher BL, La Spada AR. PMID: 33046555; PMCID: PMC7643294.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    2. Enhanced retinal responses in Huntington's disease patients. J Huntingtons Dis. 2017; 6(3):237-247. Pearl JR, Heath LM, Bergey DE, Kelly JP, Smith C, Laurino MY, Weiss A, Price ND, LaSpada A, Bird TD, Jayadev S. PMID: 28968243.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    3. RNA interference-based therapy for spinocerebellar ataxia type 7 retinal degeneration. PLoS One. 2014; 9(4):e95362. Ramachandran PS, Bhattarai S, Singh P, Boudreau RL, Thompson S, Laspada AR, Drack AV, Davidson BL. PMID: 24759684; PMCID: PMC3997397.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    4. A β-synuclein mutation linked to dementia produces neurodegeneration when expressed in mouse brain. Nat Commun. 2010 Nov 02; 1:110. Fujita M, Sugama S, Sekiyama K, Sekigawa A, Tsukui T, Nakai M, Waragai M, Takenouchi T, Takamatsu Y, Wei J, Rockenstein E, Laspada AR, Masliah E, Inoue S, Hashimoto M. PMID: 21045828; PMCID: PMC3060620.
      View in: PubMed   Mentions: 42     Fields:    
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