Albert La Spada • UCI Profiles

Albert Russell La Spada

Title(s)	Professor, Pathology
School	School of Medicine
Address	1001 Health Sciences Road Irvine CA 92697-3950
Phone	(949) 824-7407
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Research

Research Activities and Funding

Engineered AAV vectors for combinatorial treatment of rare genetic brain diseases
NIH R01FD007478Sep 1, 2021 - Aug 31, 2024
Role: Co-Principal Investigator

La Spada Outstanding Investigator Award
NIH R35NS122140May 15, 2021 - Apr 30, 2029
Role: Principal Investigator

Ataxia Investigators Meeting 8: Leveraging Therapeutic Opportunity into Novel Treatment Paradigms
NIH R13NS115342Mar 1, 2020 - Feb 28, 2021
Role: Principal Investigator

Enhanced skeletal muscle proteostasis as a determinant of CNS protein quality control and neural function in the aging brain
NIH RF1AG057264Sep 15, 2017 - Jun 30, 2022
Role: Principal Investigator

Deconstructing the cellular and molecular basis of SBMA motor neuron disease: From mechanism to therapy
NIH R01NS100023Sep 30, 2016 - Aug 31, 2021
Role: Principal Investigator

Ataxin-7 oligonucleotide knock-down to treat SCA7 retinal and cerebellar disease
NIH R01EY024747Aug 1, 2014 - Jul 31, 2018
Role: Principal Investigator

Antisense oligonucleotide knock-down of ataxin-7 in a SCA7 mouse model
NIH R21NS082112Sep 30, 2012 - Aug 31, 2014
Role: Principal Investigator

Huntington's Disease Natural Product Drug Discovery
NIH R21AG038772Sep 1, 2011 - Aug 31, 2015
Role: Co-Principal Investigator

Neuronal RNA processing defects in ALS4 caused by SETX mutations
NIH R01GM094384Aug 1, 2010 - Jul 31, 2016
Role: Co-Principal Investigator

The PPAR-delta pathway in neural function and Huntington's disease neuropathology
NIH R01NS065874Feb 1, 2010 - Jan 31, 2022
Role: Principal Investigator

Molecular genetic regulation of autophagy in health and neurodegenerative disease
NIH R01AG033082Dec 1, 2008 - May 31, 2021
Role: Principal Investigator

Non-cell autonomous neurodegeneration in SCA7
NIH R01NS052535Sep 15, 2008 - Aug 31, 2012
Role: Co-Principal Investigator

ROLE OF Nna1 IN RETINAL AND CEREBELLAR DEGENERATION
NIH R01EY014997Jul 1, 2003 - May 31, 2015
Role: Principal Investigator

SCA7 neurodegeneration: Molecular epigenetic basis and therapy
NIH R01EY014061May 1, 2002 - Jun 30, 2023
Role: Principal Investigator

MODELS OF SBMA MOTOR NEURON DEGENERATION
NIH R01NS041648Jun 1, 2001 - Aug 31, 2016
Role: Principal Investigator

CCCTC-binding factor (CTCF) in trinucleotide repeat instability and disease
NIH R01GM059356May 1, 1999 - Jan 31, 2013
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

4E-BP1 Protects Neurons from Misfolded Protein Stress and Parkinson's Disease Toxicity by Inducing the Mitochondrial Unfolded Protein Response. J Neurosci. 2020 11 04; 40(45):8734-8745. Dastidar SG, Pham MT, Mitchell MB, Yeom SG, Jordan S, Chang A, Sopher BL, La Spada AR. PMID: 33046555; PMCID: PMC7643294.

View in: PubMed Mentions: 7 Fields:
Neu Neurology
Translation:Animals Cells
Enhanced retinal responses in Huntington's disease patients. J Huntingtons Dis. 2017; 6(3):237-247. Pearl JR, Heath LM, Bergey DE, Kelly JP, Smith C, Laurino MY, Weiss A, Price ND, LaSpada A, Bird TD, Jayadev S. PMID: 28968243.

View in: PubMed Mentions: 8 Fields:
Neu Neurology
Translation:Humans Cells
RNA interference-based therapy for spinocerebellar ataxia type 7 retinal degeneration. PLoS One. 2014; 9(4):e95362. Ramachandran PS, Bhattarai S, Singh P, Boudreau RL, Thompson S, Laspada AR, Drack AV, Davidson BL. PMID: 24759684; PMCID: PMC3997397.

View in: PubMed Mentions: 19 Fields:
Med Medicine (General)Sci Science
Translation:Humans Animals
A β-synuclein mutation linked to dementia produces neurodegeneration when expressed in mouse brain. Nat Commun. 2010 Nov 02; 1:110. Fujita M, Sugama S, Sekiyama K, Sekigawa A, Tsukui T, Nakai M, Waragai M, Takenouchi T, Takamatsu Y, Wei J, Rockenstein E, Laspada AR, Masliah E, Inoue S, Hashimoto M. PMID: 21045828; PMCID: PMC3060620.

View in: PubMed Mentions: 42 Fields:
Bio Biology Sci Science