Thu Huy Le

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(714) 456-3874
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    GSTM1-Transsulfuration metabolic axis in kidney disease: therapeutic target in precision medicine
    NIH R01DK136064Mar 21, 2024 - Jan 31, 2029
    Role: Principal Investigator
    Safety, Feasibility and Efficacy of Sulforaphane in Chronic Kidney Disease
    NIH R01DK128677Sep 1, 2021 - Jun 30, 2025
    Role: Principal Investigator
    Renal Mechanisms of Blood Pressure Regulation and Salt Sensitivity by Collectrin
    NIH R01DK113632Aug 15, 2017 - May 31, 2022
    Role: Principal Investigator
    Institutional Career Development Core
    NIH KL2TR001999Aug 15, 2016 - Jun 30, 2025
    Role: Principal Investigator
    GSTM1, APOL1, and their joint contribution to severity of hypertension and chronic kidney disease
    NIH R01DK094907Apr 27, 2012 - May 31, 2022
    Role: Principal Investigator
    Genes That Regulate Progression of Kidney Disease and Its Cardiovascular Effects
    NIH R01DK075035Jun 1, 2007 - Jun 30, 2012
    Role: Principal Investigator
    GENETIC MODIFIERS IN ANGIOTENSIN RECEPTOR-DEFICIENCY
    NIH K08DK002941Apr 15, 2001 - Mar 31, 2007
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Closing the gap on antifungal resistance. Nat Med. 2026 May; 32(5):1586-1591. Verweij PE, Alastruey-Izquierdo A, Amilon K, Cavling Arendrup M, Armstrong-James D, Bignell E, Boulware DR, Brandão J, Bromley M, Brown GD, Buil JB, Chakrabarti A, Chayakulkeeree M, Chiller T, Chindamporn A, Colombo AL, Cornely OA, Dannaoui E, Dufresne PJ, Forastiero A, Gangneux JP, Giske C, Govender NP, Gow NAR, Guillot J, Harrison T, Hoenigl M, Kontoyiannis DP, Lass-Flörl C, Le T, Li R, Medina N, Meis JF, Meletiadis J, Oladele RO, Ostrosky-Zeichner L, Patel AK, Perfect JR, Queiroz-Telles F, Rodriguez-Tudela JL, Rudramurthy SM, Salmanton García J, Dos Santos AR, Segal E, Seyedmousavi A, Song Y, Thompson GR, Vena A, Warris A, Wiederhold NP, Lackner M, International Society for Human and Animal Mycology (ISHAM), Asia Fungal Working Group (AFWG), Pan-Africa Mycology Working Group (PAMWG), INFOCUS LATAM ISHAM associated Working Group, ISHAM/ECMM One Health Working Group (Focus AMR), ISHAM Environmental Fungal Exposure and Human Health Working Group, ISHAM Veterinary Mycology and One Health Working Group, ISHAM Sporotrichosis One Health Working Group, European Confederation for Medical Mycology (ECMM), ESCMID Fungal Infection Study Group (EFISG), Antifungal Susceptibility Testing Subcommittee of the European Committee on Antimicrobial Susceptibi, Clinical and Laboratory Standards Institute (CLSI) Subcommittee on Antifungal Susceptibility Tests, Mycoses Study Group Education and Research Consortium (MSGERC), Global Action for Fungal Infection (GAFFI), Medical Research Council Centre for Medical Mycology at the University of Exeter, Fungal One Health and Antimicrobial Resistance Network (F1AMR). PMID: 41986735.
      View in: PubMed   Mentions:    Fields:    
    2. Development Framework of Desirability of Outcome Ranking Endpoints for Use in Clinical Trials of Invasive Fungal Diseases. Open Forum Infect Dis. 2026 Jan; 13(1):ofag012. Portugal Gonzales J, Ampel NM, Boulware DR, Donovan FM, Le T, McCarty TP, Miceli MH, McGwin G, Pappas PG, Pasqualotto AC, Thompson GR, Walsh TJ, Ostrosky-Zeichner L. PMID: 41626302; PMCID: PMC12856023.
      View in: PubMed   Mentions: Translation:CTClinical Trials
    3. In vitro evidence to support amphotericin B and flucytosine combination therapy for talaromycosis. PLoS Negl Trop Dis. 2025 Dec; 19(12):e0013884. Natesan Sambath H, Vitsupakorn S, Sreerama Reddy K, Brown L, Nguyen TTM, Burke M, Liu J, Evans E, Giamberardino C, Perfect J, Hoa NT, Le T. PMID: 41474803; PMCID: PMC12782420.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    4. Understanding the kidney replacement therapy decision-making process. BMC Nephrol. 2025 11 26; 27(1):3. Prakash S, Vangala S, Razvi K, Taylor MH, Drury E, D'Alfonso M, Oliveira I, Le TH, Veazie P, McIntosh S. PMID: 41291522; PMCID: PMC12764139.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. In Vitro Evidence to Support Amphotericin B and Flucytosine Combination Therapy for Talaromycosis. bioRxiv. 2025 Sep 30. Sambath HN, Vitsupakorn S, Reddy KS, Brown L, Nguyen Thi Mai T, Burke M, Liu J, Evans E, Giamberardino C, Perfect J, Ngo Thi H, Le T. PMID: 41040159; PMCID: PMC12485967.
      View in: PubMed   Mentions:
    6. Racial and Ethnic Disparities in Outcomes following Preemptive Kidney Transplant Waitlisting in the United States from 2009 to 2024. J Am Soc Nephrol. 2026 Mar 01; 37(3):569-581. Adeyemo S, Crews DC, Lentine KL, Zisman-Ilani Y, Lincoln KD, Flores GM, Bunnapradist S, Ferrey AJ, Reddy UG, Muzaale AD, Rule AD, Saunders M, Garg AX, Le TH, Rhee CM, Kalantar-Zadeh K, Al Ammary F. PMID: 40956672; PMCID: PMC12935354.
      View in: PubMed   Mentions:    Fields:    
    7. Developing a Computable Phenotype for Identifying Children, Adolescents, and Young Adults With Diabetes Using Electronic Health Records in the DiCAYA Network. Diabetes Care. 2025 Jun 01; 48(6):914-921. Shao H, Thorpe LE, Islam S, Bian J, Guo Y, Li P, Bost S, Dabelea D, Conway R, Crume T, Schwartz BS, Hirsch AG, Allen KS, Dixon BE, Grannis SJ, Lustigova E, Reynolds K, Rosenman M, Zhong VW, Wong A, Rivera P, Le T, Akerman M, Conderino S, Rajan A, Liese AD, Rudisill C, Obeid JS, Ewing JA, Bailey C, Mendonca EA, Zaganjor I, Rolka D, Imperatore G, Pavkov ME, Divers J, DiCAYA Study Group . PMID: 40163581; PMCID: PMC12094193.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    8. Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials. Nat Commun. 2024 Feb 05; 15(1):1075. Axfors C, Schmitt AM, Janiaud P, Van't Hooft J, Abd-Elsalam S, Abdo EF, Abella BS, Akram J, Amaravadi RK, Angus DC, Arabi YM, Azhar S, Baden LR, Baker AW, Belkhir L, Benfield T, Berrevoets MAH, Chen CP, Chen TC, Cheng SH, Cheng CY, Chung WS, Cohen YZ, Cowan LN, Dalgard O, de Almeida E Val FF, de Lacerda MVG, de Melo GC, Derde L, Dubee V, Elfakir A, Gordon AC, Hernandez-Cardenas CM, Hills T, Hoepelman AIM, Huang YW, Igau B, Jin R, Jurado-Camacho F, Khan KS, Kremsner PG, Kreuels B, Kuo CY, Le T, Lin YC, Lin WP, Lin TH, Lyngbakken MN, McArthur C, McVerry BJ, Meza-Meneses P, Monteiro WM, Morpeth SC, Mourad A, Mulligan MJ, Murthy S, Naggie S, Narayanasamy S, Nichol A, Novack LA, O'Brien SM, Okeke NL, Perez L, Perez-Padilla R, Perrin L, Remigio-Luna A, Rivera-Martinez NE, Rockhold FW, Rodriguez-Llamazares S, Rolfe R, Rosa R, Røsjø H, Sampaio VS, Seto TB, Shahzad M, Soliman S, Stout JE, Thirion-Romero I, Troxel AB, Tseng TY, Turner NA, Ulrich RJ, Walsh SR, Webb SA, Weehuizen JM, Velinova M, Wong HL, Wrenn R, Zampieri FG, Zhong W, Moher D, Goodman SN, Ioannidis JPA, Hemkens LG. PMID: 38316844; PMCID: PMC10844287.
      View in: PubMed   Mentions: 1     Fields:    
    9. Extracellular Vesicles in Kidney Diseases: Moving Forward. Kidney360. 2023 02 01; 4(2):245-257. Erdbrügger U, Hoorn EJ, Le TH, Blijdorp CJ, Burger D. PMID: 36821616; PMCID: PMC10103258.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    10. Noninvasive Testing and Surrogate Markers in Invasive Fungal Diseases. Open Forum Infect Dis. 2022 Jun; 9(6):ofac112. Thompson GR, Boulware DR, Bahr NC, Clancy CJ, Harrison TS, Kauffman CA, Le T, Miceli MH, Mylonakis E, Nguyen MH, Ostrosky-Zeichner L, Patterson TF, Perfect JR, Spec A, Kontoyiannis DP, Pappas PG. PMID: 35611348; PMCID: PMC9124589.
      View in: PubMed   Mentions: 21  
    11. Urine Uromodulin and Genetics of its Variation. J Am Soc Nephrol. 2022 03; 33(3):461-462. Franceschini N, Le TH. PMID: 35228296; PMCID: PMC8975060.
      View in: PubMed   Mentions: 1     Fields:    
    12. Association of GSTM1 Deletion With Progression of CKD in Children: Findings From the Chronic Kidney Disease in Children (CKiD) Study. Am J Kidney Dis. 2022 07; 80(1):79-86. Levy RV, Reidy KJ, Le TH, David V, Winkler C, Xu Y, Warady B, Furth S, Kaskel F, Melamed ML. PMID: 34871703; PMCID: PMC9166174.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    13. Global guideline for the diagnosis and management of the endemic mycoses: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology. Lancet Infect Dis. 2021 12; 21(12):e364-e374. Thompson GR, Le T, Chindamporn A, Kauffman CA, Alastruey-Izquierdo A, Ampel NM, Andes DR, Armstrong-James D, Ayanlowo O, Baddley JW, Barker BM, Lopes Bezerra L, Buitrago MJ, Chamani-Tabriz L, Chan JFW, Chayakulkeeree M, Cornely OA, Cunwei C, Gangneux JP, Govender NP, Hagen F, Hedayati MT, Hohl TM, Jouvion G, Kenyon C, Kibbler CC, Klimko N, Kong DCM, Krause R, Lee Lee L, Meintjes G, Miceli MH, Rath PM, Spec A, Queiroz-Telles F, Variava E, Verweij PE, Schwartz IS, Pasqualotto AC. PMID: 34364529; PMCID: PMC9450022.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimalsPHPublic Health
    14. Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials. Nat Commun. 2021 May 14; 12(1):3001. Axfors C, Schmitt AM, Janiaud P, Van't Hooft J, Abd-Elsalam S, Abdo EF, Abella BS, Akram J, Amaravadi RK, Angus DC, Arabi YM, Azhar S, Baden LR, Baker AW, Belkhir L, Benfield T, Berrevoets MAH, Chen CP, Chen TC, Cheng SH, Cheng CY, Chung WS, Cohen YZ, Cowan LN, Dalgard O, de Almeida E Val FF, de Lacerda MVG, de Melo GC, Derde L, Dubee V, Elfakir A, Gordon AC, Hernandez-Cardenas CM, Hills T, Hoepelman AIM, Huang YW, Igau B, Jin R, Jurado-Camacho F, Khan KS, Kremsner PG, Kreuels B, Kuo CY, Le T, Lin YC, Lin WP, Lin TH, Lyngbakken MN, McArthur C, McVerry BJ, Meza-Meneses P, Monteiro WM, Morpeth SC, Mourad A, Mulligan MJ, Murthy S, Naggie S, Narayanasamy S, Nichol A, Novack LA, O'Brien SM, Okeke NL, Perez L, Perez-Padilla R, Perrin L, Remigio-Luna A, Rivera-Martinez NE, Rockhold FW, Rodriguez-Llamazares S, Rolfe R, Rosa R, Røsjø H, Sampaio VS, Seto TB, Shahzad M, Soliman S, Stout JE, Thirion-Romero I, Troxel AB, Tseng TY, Turner NA, Ulrich RJ, Walsh SR, Webb SA, Weehuizen JM, Velinova M, Wong HL, Wrenn R, Zampieri FG, Zhong W, Moher D, Goodman SN, Ioannidis JPA, Hemkens LG. PMID: 33990619; PMCID: PMC8121133.
      View in: PubMed   Mentions: 6     Fields:    
    15. Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials. Nat Commun. 2021 04 15; 12(1):2349. Axfors C, Schmitt AM, Janiaud P, Van't Hooft J, Abd-Elsalam S, Abdo EF, Abella BS, Akram J, Amaravadi RK, Angus DC, Arabi YM, Azhar S, Baden LR, Baker AW, Belkhir L, Benfield T, Berrevoets MAH, Chen CP, Chen TC, Cheng SH, Cheng CY, Chung WS, Cohen YZ, Cowan LN, Dalgard O, de Almeida E Val FF, de Lacerda MVG, de Melo GC, Derde L, Dubee V, Elfakir A, Gordon AC, Hernandez-Cardenas CM, Hills T, Hoepelman AIM, Huang YW, Igau B, Jin R, Jurado-Camacho F, Khan KS, Kremsner PG, Kreuels B, Kuo CY, Le T, Lin YC, Lin WP, Lin TH, Lyngbakken MN, McArthur C, McVerry BJ, Meza-Meneses P, Monteiro WM, Morpeth SC, Mourad A, Mulligan MJ, Murthy S, Naggie S, Narayanasamy S, Nichol A, Novack LA, O'Brien SM, Okeke NL, Perez L, Perez-Padilla R, Perrin L, Remigio-Luna A, Rivera-Martinez NE, Rockhold FW, Rodriguez-Llamazares S, Rolfe R, Rosa R, Røsjø H, Sampaio VS, Seto TB, Shahzad M, Soliman S, Stout JE, Thirion-Romero I, Troxel AB, Tseng TY, Turner NA, Ulrich RJ, Walsh SR, Webb SA, Weehuizen JM, Velinova M, Wong HL, Wrenn R, Zampieri FG, Zhong W, Moher D, Goodman SN, Ioannidis JPA, Hemkens LG. PMID: 33859192; PMCID: PMC8050319.
      View in: PubMed   Mentions: 175     Fields:    Translation:HumansCells
    16. GSTM1 Deletion Exaggerates Kidney Injury in Experimental Mouse Models and Confers the Protective Effect of Cruciferous Vegetables in Mice and Humans. J Am Soc Nephrol. 2020 01; 31(1):102-116. Gigliotti JC, Tin A, Pourafshar S, Cechova S, Wang YT, Sung SJ, Bodonyi-Kovacs G, Cross JV, Yang G, Nguyen N, Chan F, Rebholz C, Yu B, Grove ML, Grams ME, Köttgen A, Scharpf R, Ruiz P, Boerwinkle E, Coresh J, Le TH. PMID: 31727850; PMCID: PMC6935006.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    17. Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies. Nat Commun. 2019 01 03; 10(1):29. Morris AP, Le TH, Wu H, Akbarov A, van der Most PJ, Hemani G, Smith GD, Mahajan A, Gaulton KJ, Nadkarni GN, Valladares-Salgado A, Wacher-Rodarte N, Mychaleckyj JC, Dueker ND, Guo X, Hai Y, Haessler J, Kamatani Y, Stilp AM, Zhu G, Cook JP, Ärnlöv J, Blanton SH, de Borst MH, Bottinger EP, Buchanan TA, Cechova S, Charchar FJ, Chu PL, Damman J, Eales J, Gharavi AG, Giedraitis V, Heath AC, Ipp E, Kiryluk K, Kramer HJ, Kubo M, Larsson A, Lindgren CM, Lu Y, Madden PAF, Montgomery GW, Papanicolaou GJ, Raffel LJ, Sacco RL, Sanchez E, Stark H, Sundstrom J, Taylor KD, Xiang AH, Zivkovic A, Lind L, Ingelsson E, Martin NG, Whitfield JB, Cai J, Laurie CC, Okada Y, Matsuda K, Kooperberg C, Chen YI, Rundek T, Rich SS, Loos RJF, Parra EJ, Cruz M, Rotter JI, Snieder H, Tomaszewski M, Humphreys BD, Franceschini N. PMID: 30604766; PMCID: PMC6318312.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCells
    18. Leave no one behind: response to new evidence and guidelines for the management of cryptococcal meningitis in low-income and middle-income countries. Lancet Infect Dis. 2019 04; 19(4):e143-e147. Loyse A, Burry J, Cohn J, Ford N, Chiller T, Ribeiro I, Koulla-Shiro S, Mghamba J, Ramadhani A, Nyirenda R, Aliyu SH, Wilson D, Le T, Oladele R, Lesikari S, Muzoora C, Kalata N, Temfack E, Mapoure Y, Sini V, Chanda D, Shimwela M, Lakhi S, Ngoma J, Gondwe-Chunda L, Perfect C, Shroufi A, Andrieux-Meyer I, Chan A, Schutz C, Hosseinipour M, Van der Horst C, Klausner JD, Boulware DR, Heyderman R, Lalloo D, Day J, Jarvis JN, Rodrigues M, Jaffar S, Denning D, Migone C, Doherty M, Lortholary O, Dromer F, Stack M, Molloy SF, Bicanic T, van Oosterhout J, Mwaba P, Kanyama C, Kouanfack C, Mfinanga S, Govender N, Harrison TS. PMID: 30344084.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimals
    19. Ets in the Kidney-Unraveling the Molecular Mechanism Underlying Renal Damage in Salt-Sensitive Hypertension. J Am Soc Nephrol. 2017 11; 28(11):3131-3133. Gigliotti JC, Le TH. PMID: 29038288; PMCID: PMC5661301.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    20. MYH9 E1841K Mutation Augments Proteinuria and Podocyte Injury and Migration. J Am Soc Nephrol. 2018 01; 29(1):155-167. Cechova S, Dong F, Chan F, Kelley MJ, Ruiz P, Le TH. PMID: 28993503; PMCID: PMC5748898.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    21. The Loss of GSTM1 Associates with Kidney Failure and Heart Failure. J Am Soc Nephrol. 2017 Nov; 28(11):3345-3352. Tin A, Scharpf R, Estrella MM, Yu B, Grove ML, Chang PP, Matsushita K, Köttgen A, Arking DE, Boerwinkle E, Le TH, Coresh J, Grams ME. PMID: 28720685; PMCID: PMC5661294.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    22. Rare variants in fox-1 homolog A (RBFOX1) are associated with lower blood pressure. PLoS Genet. 2017 03; 13(3):e1006678. He KY, Wang H, Cade BE, Nandakumar P, Giri A, Ware EB, Haessler J, Liang J, Smith JA, Franceschini N, Le TH, Kooperberg C, Edwards TL, Kardia SL, Lin X, Chakravarti A, Redline S, Zhu X. PMID: 28346479; PMCID: PMC5386302.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    23. Renal Collectrin Protects against Salt-Sensitive Hypertension and Is Downregulated by Angiotensin II. J Am Soc Nephrol. 2017 Jun; 28(6):1826-1837. Chu PL, Gigliotti JC, Cechova S, Bodonyi-Kovacs G, Chan F, Ralph DL, Howell N, Kalantari K, Klibanov AL, Carey RM, McDonough AA, Le TH. PMID: 28062568; PMCID: PMC5461790.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    24. Proximal Tubule CD73 Is Critical in Renal Ischemia-Reperfusion Injury Protection. J Am Soc Nephrol. 2017 Mar; 28(3):888-902. Sung SJ, Li L, Huang L, Lawler J, Ye H, Rosin DL, Vincent IS, Le TH, Yu J, Görldt N, Schrader J, Okusa MD. PMID: 27628903; PMCID: PMC5328157.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    25. Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity. Am J Hum Genet. 2016 Sep 01; 99(3):636-646. Mahajan A, Rodan AR, Le TH, Gaulton KJ, Haessler J, Stilp AM, Kamatani Y, Zhu G, Sofer T, Puri S, Schellinger JN, Chu PL, Cechova S, van Zuydam N, SUMMIT Consortium, BioBank Japan Project, Arnlov J, Flessner MF, Giedraitis V, Heath AC, Kubo M, Larsson A, Lindgren CM, Madden PAF, Montgomery GW, Papanicolaou GJ, Reiner AP, Sundström J, Thornton TA, Lind L, Ingelsson E, Cai J, Martin NG, Kooperberg C, Matsuda K, Whitfield JB, Okada Y, Laurie CC, Morris AP, Franceschini N. PMID: 27588450; PMCID: PMC5011075.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    26. Combined Effects of GSTM1 Null Allele and APOL1 Renal Risk Alleles in CKD Progression in the African American Study of Kidney Disease and Hypertension Trial. J Am Soc Nephrol. 2016 Oct; 27(10):3140-3152. Bodonyi-Kovacs G, Ma JZ, Chang J, Lipkowitz MS, Kopp JB, Winkler CA, Le TH. PMID: 26940095; PMCID: PMC5042657.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    27. Extracellular Vesicles in Renal Diseases: More than Novel Biomarkers? J Am Soc Nephrol. 2016 Jan; 27(1):12-26. Erdbrügger U, Le TH. PMID: 26251351; PMCID: PMC4696584.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansCells
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