Thomas P Burke

Title(s)Assistant Professor, Microbiology and Molecular Genetics
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-7570
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    Deciphering innate and adaptive immune responses to Rickettsia parkeri
    NIH R01AI185119Jun 20, 2025 - May 31, 2030
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A genetic screen identifies O-antigen as essential for Rickettsia parkeri survival in macrophages by protecting from inflammasomes and interferon-stimulated genes. bioRxiv. 2026 Jun 13. Sun H, Guzman AA, Burke TP. PMID: 42327330; PMCID: PMC13278182.
      View in: PubMed   Mentions:
    2. Innate immune responses to Rickettsia: emerging themes and contrasts between species. Curr Opin Microbiol. 2026 Jun; 91:102754. Ly N, Guzman AA, Engström P, Burke TP. PMID: 41996866; PMCID: PMC13151960.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Correction: Interferon receptor-deficient mice are susceptible to eschar-associated rickettsiosis. Elife. 2025 Dec 19; 14. Burke TP, Engström P, Tran CJ, Langohr IM, Glasner DR, Espinosa DA, Harris E, Welch MD. PMID: 41416589; PMCID: PMC12716835.
      View in: PubMed   Mentions:    Fields:    
    4. Host glutathione is required for Rickettsia parkeri cell division and intracellular survival. Nat Commun. 2025 Jul 01; 16(1):5547. Sun H, Luu AP, Danielson M, Burke TP. PMID: 40593553; PMCID: PMC12216324.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. Comparative virulence analysis of seven diverse strains of Orientia tsutsugamushi reveals a multifaceted and complex interplay of virulence factors responsible for disease. PLoS Pathog. 2025 Jun; 21(6):e1012833. Chaichana P, Satapoomin N, Kullapanich C, Chuenklin S, Mohammad A, Inthawong M, Ball EE, Burke TP, Sunyakumthorn P, Salje J. PMID: 40587585; PMCID: PMC12237263.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    6. Differences between human and rodent nitric oxide production dictate susceptibility to tick-borne Rickettsia. bioRxiv. 2025 Jun 29. Luu AP, Guzman AA, Bouin A, Drayman N, Burke TP. PMID: 40667323; PMCID: PMC12262659.
      View in: PubMed   Mentions:
    7. Cytosolic bacterial pathogens activate TLR pathways in tumors that synergistically enhance STING agonist cancer therapies. iScience. 2024 Dec 20; 27(12):111385. Danielson M, Nicolai CJ, Vo TT, Wolf NK, Burke TP. PMID: 39669426; PMCID: PMC11635009.
      View in: PubMed   Mentions: 3  
    8. Cytosolic bacterial pathogens activate TLR pathways in tumors that synergistically enhance STING agonist cancer therapies. bioRxiv. 2024 Feb 02. Danielson M, Nicolai CJ, Vo TT, Wolf N, Burke TP. PMID: 38352567; PMCID: PMC10862861.
      View in: PubMed   Mentions:
    9. A patatin-like phospholipase mediates Rickettsia parkeri escape from host membranes. Nat Commun. 2022 06 27; 13(1):3656. Borgo GM, Burke TP, Tran CJ, Lo NTN, Engström P, Welch MD. PMID: 35760786; PMCID: PMC9237051.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    10. Interferon receptor-deficient mice are susceptible to eschar-associated rickettsiosis. Elife. 2021 08 23; 10. Burke TP, Engström P, Tran CJ, Langohr IM, Glasner DR, Espinosa DA, Harris E, Welch MD. PMID: 34423779; PMCID: PMC8428839.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    11. Lysine methylation shields an intracellular pathogen from ubiquitylation and autophagy. Sci Adv. 2021 06; 7(26). Engström P, Burke TP, Tran CJ, Iavarone AT, Welch MD. PMID: 34172444; PMCID: PMC8232902.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    12. Inflammasome-mediated antagonism of type I interferon enhances Rickettsia pathogenesis. Nat Microbiol. 2020 05; 5(5):688-696. Burke TP, Engström P, Chavez RA, Fonbuena JA, Vance RE, Welch MD. PMID: 32123346; PMCID: PMC7239376.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    13. Erratum for Ahyong et al., "A Metabolic Dependency for Host Isoprenoids in the Obligate Intracellular Pathogen Rickettsia parkeri Underlies a Sensitivity to the Statin Class of Host-Targeted Therapeutics". mSphere. 2019 Nov 27; 4(6). Ahyong V, Berdan CA, Burke TP, Nomura DK, Welch MD. PMID: 31776245; PMCID: PMC6881724.
      View in: PubMed   Mentions:    Fields:    
    14. A Metabolic Dependency for Host Isoprenoids in the Obligate Intracellular Pathogen Rickettsia parkeri Underlies a Sensitivity to the Statin Class of Host-Targeted Therapeutics. mSphere. 2019 11 13; 4(6). Ahyong V, Berdan CA, Burke TP, Nomura DK, Welch MD. PMID: 31722991; PMCID: PMC6854040.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    15. Evasion of autophagy mediated by Rickettsia surface protein OmpB is critical for virulence. Nat Microbiol. 2019 12; 4(12):2538-2551. Engström P, Burke TP, Mitchell G, Ingabire N, Mark KG, Golovkine G, Iavarone AT, Rape M, Cox JS, Welch MD. PMID: 31611642; PMCID: PMC6988571.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    16. RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread. mBio. 2018 05 15; 9(3). McFarland AP, Burke TP, Carletti AA, Glover RC, Tabakh H, Welch MD, Woodward JJ. PMID: 29764944; PMCID: PMC5954220.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    17. The Unexpected Effects of the Combination of Antibiotics and Immunity. Cell. 2018 02 22; 172(5):891-893. Burke TP. PMID: 29474916.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    18. SpoVG Is a Conserved RNA-Binding Protein That Regulates Listeria monocytogenes Lysozyme Resistance, Virulence, and Swarming Motility. mBio. 2016 04 05; 7(2):e00240. Burke TP, Portnoy DA. PMID: 27048798; PMCID: PMC4959528.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    19. A prl mutation in SecY suppresses secretion and virulence defects of Listeria monocytogenes secA2 mutants. J Bacteriol. 2015 Mar; 197(5):932-42. Durack J, Burke TP, Portnoy DA. PMID: 25535272; PMCID: PMC4325107.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    20. Community socioeconomic disadvantage and the survival of infants with congenital heart defects. Am J Public Health. 2014 Nov; 104(11):e150-7. Kucik JE, Nembhard WN, Donohue P, Devine O, Wang Y, Minkovitz CS, Burke T. PMID: 25211743; PMCID: PMC4202971.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    21. Listeria monocytogenes is resistant to lysozyme through the regulation, not the acquisition, of cell wall-modifying enzymes. J Bacteriol. 2014 Nov; 196(21):3756-67. Burke TP, Loukitcheva A, Zemansky J, Wheeler R, Boneca IG, Portnoy DA. PMID: 25157076; PMCID: PMC4248804.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    22. Role of health insurance on the survival of infants with congenital heart defects. Am J Public Health. 2014 Sep; 104(9):e62-70. Kucik JE, Cassell CH, Alverson CJ, Donohue P, Tanner JP, Minkovitz CS, Correia J, Burke T, Kirby RS. PMID: 25033158; PMCID: PMC4151915.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    23. Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity. Proc Natl Acad Sci U S A. 2011 Jul 26; 108(30):12419-24. Sauer JD, Pereyre S, Archer KA, Burke TP, Hanson B, Lauer P, Portnoy DA. PMID: 21746921; PMCID: PMC3145703.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCellsPHPublic Health
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