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Theodore Robertson Pak

Photo of Theodore Robertson Pak
Title(s)Assistant Professor In Residence, Medicine
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
ORCID ORCID Icon0000-0002-1676-2523 Additional info
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    Collapse Biography 
    Collapse education and training
    Harvard College, Cambridge, MAAB05/2011Biochemical Sciences
    Icahn School of Medicine at Mount Sinai, New York, NYPhD09/2017Biomedical Sciences
    Icahn School of Medicine at Mount Sinai, New York, NYMD05/2019Medicine
    Massachusetts General Hospital, Boston, MAResidency06/2021Internal Medicine
    Mass General Brigham, Boston, MAFellowship06/2025Infectious Diseases

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    Identifying Sepsis Phenotypes Associated with Antibiotic-Resistant Pathogens Using Large Language Models and Machine Learning
    NIH K08HS030118Aug 1, 2024 - Jul 31, 2029
    Role: Principal Investigator
    Multiscale analysis of immune profiling data from dengue and chikungunya virus infections in humans
    NIH F30AI122673Jun 13, 2016 - Jun 12, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hospital unit colonization pressure and nosocomial acquisition of drug susceptible and drug resistant pathogens. medRxiv. 2025 Jun 11. Sagers L, Wei Z, McKenna C, Chan C, Agan AA, Pak TR, Rhee C, Klompas M, Kanjilal S. PMID: 40585090; PMCID: PMC12204451.
      View in: PubMed   Mentions:
    2. Association Between the Sequence of β-Lactam and Vancomycin Administration and Mortality in Patients With Suspected Sepsis. Clin Infect Dis. 2025 Apr 30; 80(4):761-769. Kondo Y, Klompas M, McKenna CS, Pak TR, Shappell CN, DelloStritto L, Rhee C. PMID: 39657016; PMCID: PMC12043061.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Protecting patients and peers from healthcare personnel with respiratory viral infections. Infect Control Hosp Epidemiol. 2025 Jan 27; 1-3. Klompas M, Pak T, Rhee C. PMID: 39865750.
      View in: PubMed   Mentions:    Fields:    
    4. Testing and Masking Policies and Hospital-Onset Respiratory Viral Infections. JAMA Netw Open. 2024 Nov 04; 7(11):e2448063. Pak TR, Chen T, Kanjilal S, McKenna CS, Rhee C, Klompas M. PMID: 39602124; PMCID: PMC12549082.
      View in: PubMed   Mentions:    Fields:    
    5. Assessment of Racial, Ethnic, and Sex-Based Disparities in Time-to-Antibiotics and Sepsis Outcomes in a Large Multihospital Cohort. Crit Care Med. 2024 Dec 01; 52(12):1928-1933. Pak TR, Sánchez SM, McKenna CS, Rhee C, Klompas M. PMID: 39283189; PMCID: PMC12782808.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Morbidity and Mortality of Hospital-Onset SARS-CoV-2 Infections Due to Omicron Versus Prior Variants : A Propensity-Matched Analysis. Ann Intern Med. 2024 Aug; 177(8):1078-1088. Klompas M, McKenna CS, Kanjilal S, Pak T, Rhee C, Chen T. PMID: 39008853; PMCID: PMC11822919.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. In Support of Universal Admission Testing for SARS-CoV-2 During Significant Community Transmission. Clin Infect Dis. 2024 02 17; 78(2):439-444. Rhee C, Klompas M, Pak TR, Köhler JR. PMID: 37463411; PMCID: PMC11487105.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. Risk of Misleading Conclusions in Observational Studies of Time-to-Antibiotics and Mortality in Suspected Sepsis. Clin Infect Dis. 2023 11 30; 77(11):1534-1543. Pak TR, Young J, McKenna CS, Agan A, DelloStritto L, Filbin MR, Dutta S, Kadri SS, Septimus EJ, Rhee C, Klompas M. PMID: 37531612; PMCID: PMC10686960.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    9. Discontinuation of Universal Admission Testing for SARS-CoV-2 and Hospital-Onset COVID-19 Infections in England and Scotland. JAMA Intern Med. 2023 08 01; 183(8):877-880. Pak TR, Rhee C, Wang R, Klompas M. PMID: 37273229; PMCID: PMC10242507.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    10. Timing and Spectrum of Antibiotic Treatment for Suspected Sepsis and Septic Shock: Why so Controversial? Infect Dis Clin North Am. 2022 12; 36(4):719-733. Pak TR, Rhee C, Klompas M. PMID: 36328632.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    11. Real-Time Investigation of a Large Nosocomial Influenza A Outbreak Informed by Genomic Epidemiology. Clin Infect Dis. 2021 12 06; 73(11):e4375-e4383. Javaid W, Ehni J, Gonzalez-Reiche AS, Carreño JM, Hirsch E, Tan J, Khan Z, Kriti D, Ly T, Kranitzky B, Barnett B, Cera F, Prespa L, Moss M, Albrecht RA, Mustafa A, Herbison I, Hernandez MM, Pak TR, Alshammary HA, Sebra R, Smith ML, Krammer F, Gitman MR, Sordillo EM, Simon V, van Bakel H. PMID: 33252647; PMCID: PMC8653627.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansPHPublic Health
    12. PathoSPOT genomic epidemiology reveals under-the-radar nosocomial outbreaks. Genome Med. 2020 11 16; 12(1):96. Berbel Caban A, Pak TR, Obla A, Dupper AC, Chacko KI, Fox L, Mills A, Ciferri B, Oussenko I, Beckford C, Chung M, Sebra R, Smith M, Conolly S, Patel G, Kasarskis A, Sullivan MJ, Altman DR, van Bakel H. PMID: 33198787; PMCID: PMC7670629.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCellsPHPublic Health
    13. Epigenomic characterization of Clostridioides difficile finds a conserved DNA methyltransferase that mediates sporulation and pathogenesis. Nat Microbiol. 2020 01; 5(1):166-180. Oliveira PH, Ribis JW, Garrett EM, Trzilova D, Kim A, Sekulovic O, Mead EA, Pak T, Zhu S, Deikus G, Touchon M, Lewis-Sandari M, Beckford C, Zeitouni NE, Altman DR, Webster E, Oussenko I, Bunyavanich S, Aggarwal AK, Bashir A, Patel G, Wallach F, Hamula C, Huprikar S, Schadt EE, Sebra R, van Bakel H, Kasarskis A, Tamayo R, Shen A, Fang G. PMID: 31768029; PMCID: PMC6925328.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    14. A Complete Genome Screening Program of Clinical Methicillin-Resistant Staphylococcus aureus Isolates Identifies the Origin and Progression of a Neonatal Intensive Care Unit Outbreak. J Clin Microbiol. 2019 12; 57(12). Sullivan MJ, Altman DR, Chacko KI, Ciferri B, Webster E, Pak TR, Deikus G, Lewis-Sandari M, Khan Z, Beckford C, Rendo A, Samaroo F, Sebra R, Karam-Howlin R, Dingle T, Hamula C, Bashir A, Schadt E, Patel G, Wallach F, Kasarskis A, Gibbs K, van Bakel H. PMID: 31578260; PMCID: PMC6879278.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCellsPHPublic Health
    15. Genome Plasticity of agr-Defective Staphylococcus aureus during Clinical Infection. Infect Immun. 2018 10; 86(10). Altman DR, Sullivan MJ, Chacko KI, Balasubramanian D, Pak TR, Sause WE, Kumar K, Sebra R, Deikus G, Attie O, Rose H, Lewis M, Fulmer Y, Bashir A, Kasarskis A, Schadt EE, Richardson AR, Torres VJ, Shopsin B, van Bakel H. PMID: 30061376; PMCID: PMC6204747.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    16. Comprehensive innate immune profiling of chikungunya virus infection in pediatric cases. Mol Syst Biol. 2018 08 27; 14(8):e7862. Michlmayr D, Pak TR, Rahman AH, Amir ED, Kim EY, Kim-Schulze S, Suprun M, Stewart MG, Thomas GP, Balmaseda A, Wang L, Zhu J, Suaréz-Fariñas M, Wolinsky SM, Kasarskis A, Harris E. PMID: 30150281; PMCID: PMC6110311.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    17. Genetic Basis of Emerging Vancomycin, Linezolid, and Daptomycin Heteroresistance in a Case of Persistent Enterococcus faecium Bacteremia. Antimicrob Agents Chemother. 2018 04; 62(4). Chacko KI, Sullivan MJ, Beckford C, Altman DR, Ciferri B, Pak TR, Sebra R, Kasarskis A, Hamula CL, van Bakel H. PMID: 29339387; PMCID: PMC5913925.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    18. Estimating Local Costs Associated With Clostridium difficile Infection Using Machine Learning and Electronic Medical Records. Infect Control Hosp Epidemiol. 2017 12; 38(12):1478-1486. Pak TR, Chacko KI, O'Donnell T, Huprikar SS, van Bakel H, Kasarskis A, Scott ER. PMID: 29103378; PMCID: PMC5923033.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    19. High-dimensional CyTOF analysis of dengue virus-infected human DCs reveals distinct viral signatures. JCI Insight. 2017 Jul 06; 2(13). Hamlin RE, Rahman A, Pak TR, Maringer K, Mena I, Bernal-Rubio D, Potla U, Maestre AM, Fredericks AC, Amir ED, Kasarskis A, Ramos I, Merad M, Fernandez-Sesma A. PMID: 28679950; PMCID: PMC5499363.
      View in: PubMed   Mentions: 21     Fields:    
    20. Genomic confirmation of vancomycin-resistant Enterococcus transmission from deceased donor to liver transplant recipient. PLoS One. 2017; 12(3):e0170449. Bashir A, Attie O, Sullivan M, Sebra R, Singh KV, Altman D, Pak T, Dutta J, Chacko K, Webster E, Lewis M, Hamula C, Delli Carpini KW, Murray BE, Kasarskis A, van Bakel H, Huprikar S. PMID: 28301471; PMCID: PMC5354240.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    21. Reply to Lesho. Clin Infect Dis. 2016 Apr 15; 62(8):1053. Pak TR, Kasarskis A. PMID: 26908789.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    22. Whole-genome sequencing identifies emergence of a quinolone resistance mutation in a case of Stenotrophomonas maltophilia bacteremia. Antimicrob Agents Chemother. 2015 Nov; 59(11):7117-20. Pak TR, Altman DR, Attie O, Sebra R, Hamula CL, Lewis M, Deikus G, Newman LC, Fang G, Hand J, Patel G, Wallach F, Schadt EE, Huprikar S, van Bakel H, Kasarskis A, Bashir A. PMID: 26324280; PMCID: PMC4604410.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    23. How next-generation sequencing and multiscale data analysis will transform infectious disease management. Clin Infect Dis. 2015 Dec 01; 61(11):1695-702. Pak TR, Kasarskis A. PMID: 26251049; PMCID: PMC4643486.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    24. A user-editable web-based platform to streamline clinical information flow. Stud Health Technol Inform. 2015; 210:909-13. Finkelstein M, Siddiqui A, Pak T, Hu K, Ciccariello C, Knabben V, Chiang D, Thomas DC, Meah YS. PMID: 25991288.
      View in: PubMed   Mentions: 1     Fields:    
    25. ChromoZoom: a flexible, fluid, web-based genome browser. Bioinformatics. 2013 Feb 01; 29(3):384-6. Pak TR, Roth FP. PMID: 23220575; PMCID: PMC3562068.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    26. Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. Nature. 2012 Jul 26; 487(7408):491-5. Rozenblatt-Rosen O, Deo RC, Padi M, Adelmant G, Calderwood MA, Rolland T, Grace M, Dricot A, Askenazi M, Tavares M, Pevzner SJ, Abderazzaq F, Byrdsong D, Carvunis AR, Chen AA, Cheng J, Correll M, Duarte M, Fan C, Feltkamp MC, Ficarro SB, Franchi R, Garg BK, Gulbahce N, Hao T, Holthaus AM, James R, Korkhin A, Litovchick L, Mar JC, Pak TR, Rabello S, Rubio R, Shen Y, Singh S, Spangle JM, Tasan M, Wanamaker S, Webber JT, Roecklein-Canfield J, Johannsen E, Barabási AL, Beroukhim R, Kieff E, Cusick ME, Hill DE, Münger K, Marto JA, Quackenbush J, Roth FP, DeCaprio JA, Vidal M. PMID: 22810586; PMCID: PMC3408847.
      View in: PubMed   Mentions: 251     Fields:    Translation:HumansCells
    27. Tuning molecule-surface interactions with sub-nanometer-thick covalently bound organic monolayers. J Phys Chem B. 2006 Jun 15; 110(23):11334-43. Camillone N, Pak TR, Adib K, Osgood RM. PMID: 16771404.
      View in: PubMed   Mentions:    Fields:    
    28. Morphine via nitric oxide modulates beta-amyloid metabolism: a novel protective mechanism for Alzheimer's disease. Med Sci Monit. 2005 Oct; 11(10):BR357-66. Pak T, Cadet P, Mantione KJ, Stefano GB. PMID: 16192893.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
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