Shiou-Chuan Tsai

Title(s)Professor, Molecular Biology & Biochemistry
SchoolSchool of Biological Sciences
Address2218 Natural Sciences 1
Zot 3900
Irvine CA 92697
Phone(949) 824-4486, 8829
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    Collapse Research 
    Collapse Research Activities and Funding
    Probing and Engineering of Iterative Polyketide Synthase
    NIH R01GM127728Jun 10, 2018 - Mar 31, 2022
    Role: Principal Investigator
    The Molecular Basis of Regio-Specificity in Fungal Polyketide Synthase
    NIH R01GM100305Feb 1, 2012 - Jan 31, 2018
    Role: Principal Investigator
    Dissecting the substrate specificity of acyl-CoA carboxylase
    NIH R03AI073426May 1, 2010 - Apr 30, 2012
    Role: Principal Investigator
    STRUCTURE-BASED TUBERCULOSIS DRUG DESIGN TARGETED AT ACYL-COA CARBOXYLASE
    NIH R01AI076460Jul 17, 2009 - Jun 30, 2012
    Role: Principal Investigator
    The Ketoreduction and Cycilization of Aromatic Polyketide Biosynthesis
    NIH R01GM076330Jul 1, 2007 - Aug 31, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Development of a Pantetheine Force Field Library for Molecular Modeling. J Chem Inf Model. 2021 02 22; 61(2):856-868. Zhao S, Schaub AJ, Tsai SC, Luo R. PMID: 33534558; PMCID: PMC8266206.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    2. Molecular Basis for Polyketide Ketoreductase-Substrate Interactions. Int J Mol Sci. 2020 Oct 13; 21(20). Zhao S, Ni F, Qiu T, Wolff JT, Tsai SC, Luo R. PMID: 33066287; PMCID: PMC7588967.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    3. Structural basis for chain release from the enacyloxin polyketide synthase. Nat Chem. 2019 10; 11(10):913-923. Kosol S, Gallo A, Griffiths D, Valentic TR, Masschelein J, Jenner M, de Los Santos ELC, Manzi L, Sydor PK, Rea D, Zhou S, Fülöp V, Oldham NJ, Tsai SC, Challis GL, Lewandowski JR. PMID: 31548674; PMCID: PMC6783305.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    4. Molecular basis for interactions between an acyl carrier protein and a ketosynthase. Nat Chem Biol. 2019 07; 15(7):669-671. Milligan JC, Lee DJ, Jackson DR, Schaub AJ, Beld J, Barajas JF, Hale JJ, Luo R, Burkart MD, Tsai SC. PMID: 31209348; PMCID: PMC7323458.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    5. Computational structural enzymology methodologies for the study and engineering of fatty acid synthases, polyketide synthases and nonribosomal peptide synthetases. Methods Enzymol. 2019; 622:375-409. Schaub AJ, Moreno GO, Zhao S, Truong HV, Luo R, Tsai SC. PMID: 31155062; PMCID: PMC7197764.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    6. The Structural Enzymology of Iterative Aromatic Polyketide Synthases: A Critical Comparison with Fatty Acid Synthases. Annu Rev Biochem. 2018 06 20; 87:503-531. Tsai SC. PMID: 29925265.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    7. An Oxetane-Based Polyketide Surrogate To Probe Substrate Binding in a Polyketide Synthase. J Am Chem Soc. 2018 04 18; 140(15):4961-4964. Ellis BD, Milligan JC, White AR, Duong V, Altman PX, Mohammed LY, Crump MP, Crosby J, Luo R, Vanderwal CD, Tsai SC. PMID: 29620883; PMCID: PMC6625825.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    8. Structural and Functional Studies of the Daunorubicin Priming Ketosynthase DpsC. ACS Chem Biol. 2018 01 19; 13(1):141-151. Jackson DR, Shakya G, Patel AB, Mohammed LY, Vasilakis K, Wattana-Amorn P, Valentic TR, Milligan JC, Crump MP, Crosby J, Tsai SC. PMID: 29161022.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    9. A Direct Synthesis of Highly Substituted π-Rich Aromatic Heterocycles from Oxetanes. Angew Chem Int Ed Engl. 2017 08 21; 56(35):10525-10529. White AR, Kozlowski RA, Tsai SC, Vanderwal CD. PMID: 28662280.
      View in: PubMed   Mentions: 10     Fields:    
    10. Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases. Proc Natl Acad Sci U S A. 2017 05 23; 114(21):E4142-E4148. Barajas JF, Shakya G, Moreno G, Rivera H, Jackson DR, Topper CL, Vagstad AL, La Clair JJ, Townsend CA, Burkart MD, Tsai SC. PMID: 28484029; PMCID: PMC5448209.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    11. A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units. Nat Commun. 2016 12 21; 7:13609. Ray L, Valentic TR, Miyazawa T, Withall DM, Song L, Milligan JC, Osada H, Takahashi S, Tsai SC, Challis GL. PMID: 28000660; PMCID: PMC5187497.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    12. Comprehensive Analysis of a Novel Ketoreductase for Pentangular Polyphenol Biosynthesis. ACS Chem Biol. 2016 12 16; 11(12):3421-3430. Valentic TR, Jackson DR, Brady SF, Tsai SC. PMID: 27779377.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    13. Structural and Biochemical Analysis of Protein-Protein Interactions Between the Acyl-Carrier Protein and Product Template Domain. Angew Chem Int Ed Engl. 2016 10 10; 55(42):13005-13009. Barajas JF, Finzel K, Valentic TR, Shakya G, Gamarra N, Martinez D, Meier JL, Vagstad AL, Newman AG, Townsend CA, Burkart MD, Tsai SC. PMID: 27653519; PMCID: PMC5161458.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    14. An unusual intramolecular trans-amidation. Tetrahedron. 2016 Jun 23; 72(25):3605-3608. Rivera H, Dhar S, La Clair JJ, Tsai SC, Burkart MD. PMID: 27346894; PMCID: PMC4917018.
      View in: PubMed   Mentions:    Fields:    
    15. The Alga Ochromonas danica Produces Bromosulfolipids. Org Lett. 2016 Mar 04; 18(5):1124-7. White AR, Duggan BM, Tsai SC, Vanderwal CD. PMID: 26889956; PMCID: PMC6020021.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    16. Insights into Complex Oxidation during BE-7585A Biosynthesis: Structural Determination and Analysis of the Polyketide Monooxygenase BexE. ACS Chem Biol. 2016 Apr 15; 11(4):1137-47. Jackson DR, Yu X, Wang G, Patel AB, Calveras J, Barajas JF, Sasaki E, Metsä-Ketelä M, Liu HW, Rohr J, Tsai SC. PMID: 26813028; PMCID: PMC4902875.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    17. Structural and functional analysis of two di-domain aromatase/cyclases from type II polyketide synthases. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):E6844-51. Caldara-Festin G, Jackson DR, Barajas JF, Valentic TR, Patel AB, Aguilar S, Nguyen M, Vo M, Khanna A, Sasaki E, Liu HW, Tsai SC. PMID: 26631750; PMCID: PMC4687605.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    18. Structural Insights into Anthranilate Priming during Type II Polyketide Biosynthesis. ACS Chem Biol. 2016 Jan 15; 11(1):95-103. Jackson DR, Tu SS, Nguyen M, Barajas JF, Schaub AJ, Krug D, Pistorius D, Luo R, Müller R, Tsai SC. PMID: 26473393; PMCID: PMC7886370.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    19. Probing the Substrate Specificity and Protein-Protein Interactions of the E. coli Fatty Acid Dehydratase, FabA. Chem Biol. 2015 Nov 19; 22(11):1453-1460. Finzel K, Nguyen C, Jackson DR, Gupta A, Tsai SC, Burkart MD. PMID: 26526101; PMCID: PMC4656083.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    20. Comprehensive Structural and Biochemical Analysis of the Terminal Myxalamid Reductase Domain for the Engineered Production of Primary Alcohols. Chem Biol. 2015 Aug 20; 22(8):1018-29. Barajas JF, Phelan RM, Schaub AJ, Kliewer JT, Kelly PJ, Jackson DR, Luo R, Keasling JD, Tsai SC. PMID: 26235055.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    21. Modeling linear and cyclic PKS intermediates through atom replacement. J Am Chem Soc. 2014 Dec 03; 136(48):16792-9. Shakya G, Rivera H, Lee DJ, Jaremko MJ, La Clair JJ, Fox DT, Haushalter RW, Schaub AJ, Bruegger J, Barajas JF, White AR, Kaur P, Gwozdziowski ER, Wong F, Tsai SC, Burkart MD. PMID: 25406716; PMCID: PMC4277753.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    22. Trapping the dynamic acyl carrier protein in fatty acid biosynthesis. Nature. 2014 Jan 16; 505(7483):427-31. Nguyen C, Haushalter RW, Lee DJ, Markwick PR, Bruegger J, Caldara-Festin G, Finzel K, Jackson DR, Ishikawa F, O'Dowd B, McCammon JA, Opella SJ, Tsai SC, Burkart MD. PMID: 24362570; PMCID: PMC4437705.
      View in: PubMed   Mentions: 111     Fields:    Translation:Cells
    23. The determinants of activity and specificity in actinorhodin type II polyketide ketoreductase. Chem Biol. 2013 Oct 24; 20(10):1225-34. Javidpour P, Bruegger J, Srithahan S, Korman TP, Crump MP, Crosby J, Burkart MD, Tsai SC. PMID: 24035284; PMCID: PMC3855848.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    24. Probing the selectivity and protein·protein interactions of a nonreducing fungal polyketide synthase using mechanism-based crosslinkers. Chem Biol. 2013 Sep 19; 20(9):1135-46. Bruegger J, Haushalter RW, Haushalter B, Vagstad AL, Vagstad A, Shakya G, Mih N, Townsend CA, Burkart MD, Tsai SC. PMID: 23993461; PMCID: PMC3796367.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    25. Babysitting flavin for biosynthesis. Chem Biol. 2012 Jul 27; 19(7):787-8. Tsai SC. PMID: 22840764.
      View in: PubMed   Mentions: 1     Fields:    
    26. Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11144-9. Ames BD, Nguyen C, Bruegger J, Smith P, Xu W, Ma S, Wong E, Wong S, Xie X, Li JW, Vederas JC, Tang Y, Tsai SC. PMID: 22733743; PMCID: PMC3396468.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    27. Insight into the molecular basis of aromatic polyketide cyclization: crystal structure and in vitro characterization of WhiE-ORFVI. Biochemistry. 2012 Apr 10; 51(14):3079-91. Lee MY, Ames BD, Tsai SC. PMID: 22432862; PMCID: PMC3339804.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    28. Structural and biochemical characterization of ZhuI aromatase/cyclase from the R1128 polyketide pathway. Biochemistry. 2011 Oct 04; 50(39):8392-406. Ames BD, Lee MY, Moody C, Zhang W, Tang Y, Tsai SC. PMID: 21870821; PMCID: PMC3189504.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    29. Structural and biochemical studies of the hedamycin type II polyketide ketoreductase (HedKR): molecular basis of stereo- and regiospecificities. Biochemistry. 2011 Aug 30; 50(34):7426-39. Javidpour P, Das A, Khosla C, Tsai SC. PMID: 21776967; PMCID: PMC3175028.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    30. Structural and biochemical analyses of regio- and stereospecificities observed in a type II polyketide ketoreductase. Biochemistry. 2011 May 31; 50(21):4638-49. Javidpour P, Korman TP, Shakya G, Tsai SC. PMID: 21506596; PMCID: PMC3117988.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    31. Fatty acid biosynthesis in actinomycetes. FEMS Microbiol Rev. 2011 May; 35(3):475-97. Gago G, Diacovich L, Arabolaza A, Tsai SC, Gramajo H. PMID: 21204864; PMCID: PMC3079561.
      View in: PubMed   Mentions: 72     Fields:    Translation:Cells
    32. Crystal structures and mutational analyses of acyl-CoA carboxylase beta subunit of Streptomyces coelicolor. Biochemistry. 2010 Aug 31; 49(34):7367-76. Arabolaza A, Shillito ME, Lin TW, Diacovich L, Melgar M, Pham H, Amick D, Gramajo H, Tsai SC. PMID: 20690600; PMCID: PMC2927733.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    33. X-ray crystallographic structure of an artificial beta-sheet dimer. J Am Chem Soc. 2010 Aug 25; 132(33):11622-8. Khakshoor O, Lin AJ, Korman TP, Sawaya MR, Tsai SC, Eisenberg D, Nowick JS. PMID: 20669960; PMCID: PMC2929266.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    34. Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis. Proc Natl Acad Sci U S A. 2010 Apr 06; 107(14):6246-51. Korman TP, Crawford JM, Labonte JW, Newman AG, Wong J, Townsend CA, Tsai SC. PMID: 20332208; PMCID: PMC2851968.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    35. 2.6 A X-ray crystal structure of human p53R2, a p53-inducible ribonucleotide reductase . Biochemistry. 2009 Nov 24; 48(46):11134-41. Smith P, Zhou B, Ho N, Yuan YC, Su L, Tsai SC, Yen Y. PMID: 19728742; PMCID: PMC2844085.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    36. Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization. Nature. 2009 Oct 22; 461(7267):1139-43. Crawford JM, Korman TP, Labonte JW, Vagstad AL, Hill EA, Kamari-Bidkorpeh O, Tsai SC, Townsend CA. PMID: 19847268; PMCID: PMC2872118.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    37. ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria. Microbiology (Reading). 2009 Aug; 155(Pt 8):2664-2675. Kurth DG, Gago GM, de la Iglesia A, Bazet Lyonnet B, Lin TW, Morbidoni HR, Tsai SC, Gramajo H. PMID: 19423629; PMCID: PMC2865140.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    38. Influence relevance voting: an accurate and interpretable virtual high throughput screening method. J Chem Inf Model. 2009 Apr; 49(4):756-66. Swamidass SJ, Azencott CA, Lin TW, Gramajo H, Tsai SC, Baldi P. PMID: 19391629; PMCID: PMC2750043.
      View in: PubMed   Mentions: 19     Fields:    
    39. Structural enzymology of polyketide synthases. Methods Enzymol. 2009; 459:17-47. Tsai SC, Ames BD. PMID: 19362634; PMCID: PMC2873140.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    40. Structure and mutagenic conversion of E1 dehydrase: at the crossroads of dehydration, amino transfer, and epimerization. Biochemistry. 2008 Jun 17; 47(24):6329-41. Smith P, Szu PH, Bui C, Liu HW, Tsai SC. PMID: 18491919; PMCID: PMC2782820.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    41. Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides. Proc Natl Acad Sci U S A. 2008 Apr 08; 105(14):5349-54. Ames BD, Korman TP, Zhang W, Smith P, Vu T, Tang Y, Tsai SC. PMID: 18388203; PMCID: PMC2291100.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    42. Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase. Biochemistry. 2008 Feb 19; 47(7):1837-47. Korman TP, Tan YH, Wong J, Luo R, Tsai SC. PMID: 18205400; PMCID: PMC2263082.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    43. The type I fatty acid and polyketide synthases: a tale of two megasynthases. Nat Prod Rep. 2007 Oct; 24(5):1041-72. Smith S, Tsai SC. PMID: 17898897; PMCID: PMC2263081.
      View in: PubMed   Mentions: 119     Fields:    Translation:Cells
    44. Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase. Appl Environ Microbiol. 2006 Apr; 72(4):2573-80. Zhang W, Ames BD, Tsai SC, Tang Y. PMID: 16597959; PMCID: PMC1449064.
      View in: PubMed   Mentions: 40     Fields:    Translation:Cells
    45. Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3072-7. Lin TW, Melgar MM, Kurth D, Swamidass SJ, Purdon J, Tseng T, Gago G, Baldi P, Gramajo H, Tsai SC. PMID: 16492739; PMCID: PMC1413898.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    46. Biosynthesis of a 3,6-dideoxyhexose: crystallization and X-ray diffraction of CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydrase (E1) for ascarylose biosynthesis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Mar 01; 62(Pt 3):231-4. Smith P, Lin A, Szu PH, Liu HW, Tsai SC. PMID: 16511309; PMCID: PMC2197195.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    47. Biochemical and structural characterization of an essential acyl coenzyme A carboxylase from Mycobacterium tuberculosis. J Bacteriol. 2006 Jan; 188(2):477-86. Gago G, Kurth D, Diacovich L, Tsai SC, Gramajo H. PMID: 16385038; PMCID: PMC1347277.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    48. Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity. Biochemistry. 2004 Nov 23; 43(46):14529-38. Korman TP, Hill JA, Vu TN, Tsai SC. PMID: 15544323; PMCID: PMC2263080.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    49. Crystal structure of the beta-subunit of acyl-CoA carboxylase: structure-based engineering of substrate specificity. Biochemistry. 2004 Nov 09; 43(44):14027-36. Diacovich L, Mitchell DL, Pham H, Gago G, Melgar MM, Khosla C, Gramajo H, Tsai SC. PMID: 15518551.
      View in: PubMed   Mentions: 34     Fields:    Translation:Cells
    50. A fine balancing act of type III polyketide synthase. Chem Biol. 2004 Sep; 11(9):1177-8. Tsai SC. PMID: 15380178.
      View in: PubMed   Mentions: 1     Fields:    
    51. Crystal structure of an Acyl-ACP dehydrogenase from the FK520 polyketide biosynthetic pathway: insights into extender unit biosynthesis. J Mol Biol. 2003 Nov 28; 334(3):435-44. Watanabe K, Khosla C, Stroud RM, Tsai SC. PMID: 14623185.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    52. Polyketide chain length control by chain length factor. J Am Chem Soc. 2003 Oct 22; 125(42):12708-9. Tang Y, Tsai SC, Khosla C. PMID: 14558809.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    53. Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase. Structure. 2003 Feb; 11(2):147-54. Keatinge-Clay AT, Shelat AA, Savage DF, Tsai SC, Miercke LJ, O'Connell JD, Khosla C, Stroud RM. PMID: 12575934.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    54. Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway. Structure. 2002 Nov; 10(11):1559-68. Pan H, Tsai Sc, Meadows ES, Miercke LJ, Keatinge-Clay AT, O'Connell J, Khosla C, Stroud RM. PMID: 12429097.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    55. Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase. Biochemistry. 2002 Oct 22; 41(42):12590-7. Lu H, Tsai SC, Khosla C, Cane DE. PMID: 12379101.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    56. Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. Biochemistry. 2002 Oct 22; 41(42):12598-606. Tsai SC, Lu H, Cane DE, Khosla C, Stroud RM. PMID: 12379102.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
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