Robert F Phalen

Title(s)Professor, IOHC
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-4758
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    Collapse Research 
    Collapse Research Activities and Funding
    NIH R13ES012428Mar 1, 2003 - Feb 28, 2004
    Role: Principal Investigator
    NIH R01HL039682Jul 1, 1988 - May 31, 1998
    Role: Principal Investigator
    NIH R09OH000568Jul 1, 1974 - Nov 30, 1999
    Role: Co-Principal Investigator
    NIH T09OH007082Jul 1, 1974 - Sep 29, 1997
    Role: Co-Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. INHALED AEROSOL DOSIMETRY: SOME CURRENT RESEARCH NEEDS. J Aerosol Sci. 2016 Sep; 99:1-5. Darquenne C, Hoover MD, Phalen RF. PMID: 27493295; PMCID: PMC4968946.
      View in: PubMed   Mentions: 3  
    2. Dementia incidence in middle-income countries. Lancet. 2012 Oct 27; 380(9852):1470-1. Chuang JY, Phalen RF. PMID: 23101712.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Inhaled aerosol particle dosimetry in mice: a review. Inhal Toxicol. 2010 Dec; 22 Suppl 2:15-20. Méndez LB, Gookin G, Phalen RF. PMID: 21142796.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    4. New developments in aerosol dosimetry. Inhal Toxicol. 2010 Dec; 22 Suppl 2:6-14. Phalen RF, Mendez LB, Oldham MJ. PMID: 20939685.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansPHPublic Health
    5. Inhaled aerosol particle dosimetry in mice: a review. Inhal Toxicol. 2010 Oct; 22(12):1032-7. Méndez LB, Gookin G, Phalen RF. PMID: 20879957.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsPHPublic Health
    6. Commentary on ''Toxicity testing in the 21st century: a vision and a strategy''. Hum Exp Toxicol. 2010 Jan; 29(1):11-4. Phalen RF. PMID: 20061462.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    7. Dosimetry considerations for animal aerosol inhalation studies. Biomarkers. 2009 Jul; 14 Suppl 1:63-6. Phalen RF, Mendez LB. PMID: 19604062; PMCID: PMC2866373.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsPHPublic Health
    8. The relevance of animal models for aerosol studies. J Aerosol Med Pulm Drug Deliv. 2008 Mar; 21(1):113-24. Phalen RF, Oldham MJ, Wolff RK. PMID: 18518837.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    9. Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicol Appl Pharmacol. 2007 Jul 01; 222(1):122-8. Calabrese EJ, Bachmann KA, Bailer AJ, Bolger PM, Borak J, Cai L, Cedergreen N, Cherian MG, Chiueh CC, Clarkson TW, Cook RR, Diamond DM, Doolittle DJ, Dorato MA, Duke SO, Feinendegen L, Gardner DE, Hart RW, Hastings KL, Hayes AW, Hoffmann GR, Ives JA, Jaworowski Z, Johnson TE, Jonas WB, Kaminski NE, Keller JG, Klaunig JE, Knudsen TB, Kozumbo WJ, Lettieri T, Liu SZ, Maisseu A, Maynard KI, Masoro EJ, McClellan RO, Mehendale HM, Mothersill C, Newlin DB, Nigg HN, Oehme FW, Phalen RF, Philbert MA, Rattan SI, Riviere JE, Rodricks J, Sapolsky RM, Scott BR, Seymour C, Sinclair DA, Smith-Sonneborn J, Snow ET, Spear L, Stevenson DE, Thomas Y, Tubiana M, Williams GM, Mattson MP. PMID: 17459441.
      View in: PubMed   Mentions: 217     Fields:    Translation:HumansAnimals
    10. Aerosol dosimetry research needs. Inhal Toxicol. 2006 Sep; 18(10):841-3. Phalen RF, Hoover MD. PMID: 16774874.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    11. Effect of cigarette smoking on nitric oxide, structural, and mechanical properties of mouse arteries. Am J Physiol Heart Circ Physiol. 2006 Nov; 291(5):H2354-61. Guo X, Oldham MJ, Kleinman MT, Phalen RF, Kassab GS. PMID: 16815989.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    12. Tracheobronchial particle dose considerations for in vitro toxicology studies. Toxicol Sci. 2006 Jul; 92(1):126-32. Phalen RF, Oldham MJ, Nel AE. PMID: 16597657.
      View in: PubMed   Mentions: 19     Fields:    
    13. Toxicological interactions in the respiratory system after inhalation of ozone and sulfuric acid aerosol mixtures. Inhal Toxicol. 2006 Apr; 18(4):295-303. Kleinman MT, Phalen RF. PMID: 22397323.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    14. Aerosol dosimetry considerations. Clin Occup Environ Med. 2006; 5(4):773-84. Phalen RF, Oldham MJ. PMID: 17110291.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    15. The particulate air pollution controversy. Nonlinearity Biol Toxicol Med. 2004 Oct; 2(4):259-92. Phalen RF. PMID: 19330148; PMCID: PMC2659607.
      View in: PubMed   Mentions: 6  
    16. Performance of a portable whole-body mouse exposure system. Inhal Toxicol. 2004 Aug; 16(9):657-62. Oldham MJ, Phalen RF, Robinson RJ, Kleinman MT. PMID: 16036757.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsPHPublic Health
    17. Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects. Clin Immunol. 2003 Dec; 109(3):250-65. Li N, Hao M, Phalen RF, Hinds WC, Nel AE. PMID: 14697739.
      View in: PubMed   Mentions: 182     Fields:    Translation:Humans
    18. Dosimetry implications of upper tracheobronchial airway anatomy in two mouse varieties. Anat Rec. 2002 Sep 01; 268(1):59-65. Oldham MJ, Phalen RF. PMID: 12209565.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsPHPublic Health
    19. Respiratory tract responses to repeated inhalation of an oxidant and acid gas-particle air pollutant mixture. Toxicol Sci. 2001 Jun; 61(2):331-41. Mautz WJ, Kleinman MT, Bhalla DK, Phalen RF. PMID: 11353142.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    20. Preface. Inhal Toxicol. 2000 Jan; 12 Suppl 2:V. Phalen RF. PMID: 26368528.
      View in: PubMed   Mentions:    Fields:    
    21. Uncertainties relating to the health effects of particulate air pollution: the US EPA's particle standard. Toxicol Lett. 1998 Aug; 96-97:263-7. Phalen RF. PMID: 9820676.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Effects of breathing parameters on sidestream cigarette smoke deposition in a hollow tracheobronchial model. Am Ind Hyg Assoc J. 1998 Jun; 59(6):381-7. Dendo RI, Phalen RF, Mannix RC, Oldham MJ. PMID: 9670468.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    23. Deposition of monodisperse particles in hollow models representing adult and child-size tracheobronchial airways. Health Phys. 1997 Jun; 72(6):827-34. Oldham MJ, Mannix RC, Phalen RF. PMID: 9169924.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    24. Physical characterization of incense aerosols. Sci Total Environ. 1996 Dec 20; 193(2):149-58. Mannix RC, Nguyen KP, Tan EW, Ho EE, Phalen RF. PMID: 9043146.
      View in: PubMed   Mentions: 10     Fields:    Translation:PHPublic Health
    25. Surfactant dysfunction after inhalation of nitric oxide. J Appl Physiol (1985). 1996 Jun; 80(6):2026-34. Hallman M, Waffarn F, Bry K, Turbow R, Kleinman MT, Mautz WJ, Rasmussen RE, Bhalla DK, Phalen RF. PMID: 8806910.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    26. Effects of nitrogen dioxide on respiratory tract clearance in the ferret. J Toxicol Environ Health. 1994 Jan; 41(1):109-20. Rasmussen RE, Mannix RC, Oldham MJ, Phalen RF. PMID: 8277524.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    27. Low-cost wind tunnel for aerosol inhalation studies. Am Ind Hyg Assoc J. 1992 Apr; 53(4):232-6. Chung IP, Dunn-Rankin D, Phalen RF, Oldham MJ. PMID: 1529915.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    28. Inflated, dried whole lung specimens. Anat Rec. 1991 Oct; 231(2):286-92. Oldham MJ, Phalen RF. PMID: 1746727.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    29. The effect of dead space on inhaled particle deposition. J Aerosol Med. 1991; 4(4):297-311. Schum GM, Phalen RF, Oldham MJ. PMID: 10147691.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    30. Growth of the ferret tracheobronchial tree. Lab Anim Sci. 1990 Mar; 40(2):186-91. Oldham MJ, Phalen RF, Huxtable RF. PMID: 2157101.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    31. Health effects of acid aerosols formed by atmospheric mixtures. Environ Health Perspect. 1989 Feb; 79:137-45. Kleinman MT, Phalen RF, Mautz WJ, Mannix RC, McClure TR, Crocker TT. PMID: 2707193; PMCID: PMC1567561.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCellsPHPublic Health
    32. Aerosol deposition in the nose as a function of body size. Health Phys. 1989; 57 Suppl 1:299-305. Phalen RF, Oldham MJ, Mautz WJ. PMID: 2606689.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    33. Effects of exercise exposure on toxic interactions between inhaled oxidant and aldehyde air pollutants. J Toxicol Environ Health. 1988; 25(2):165-77. Mautz WJ, Kleinman MT, Phalen RF, Crocker TT. PMID: 3172271.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    34. Effects of pollutant atmospheres on surface receptors of pulmonary macrophages. J Toxicol Environ Health. 1988; 24(3):385-402. Prasad SB, Rao VS, Mannix RC, Phalen RF. PMID: 3398079.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    35. Tracheal and bronchoalveolar permeability changes in rats inhaling oxidant atmospheres during rest or exercise. J Toxicol Environ Health. 1987; 22(4):417-37. Bhalla DK, Mannix RC, Lavan SM, Phalen RF, Kleinman MT, Crocker TT. PMID: 3694704.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    36. Sequence of bronchoalveolar lavage and histopathologic findings in rat lungs early in inhalation asbestos exposure. J Toxicol Environ Health. 1987; 20(1-2):147-61. Smith CM, Batcher S, Catanzaro A, Abraham JL, Phalen R. PMID: 3806701.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    37. Effect of ozone on mean linear intercept in the lung of young beagles. J Toxicol Environ Health. 1986; 17(2-3):285-96. Phalen RF, Crocker TT, McClure TR, Tyler NK. PMID: 3959114.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    38. Postnatal enlargement of human tracheobronchial airways and implications for particle deposition. Anat Rec. 1985 Aug; 212(4):368-80. Phalen RF, Oldham MJ, Beaucage CB, Crocker TT, Mortensen JD. PMID: 4073554.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    39. A rodent treadmill for inhalation toxicological studies and respirometry. J Appl Physiol (1985). 1985 Feb; 58(2):673-9. Mautz WJ, Phalen RF, McClure TR, Bufalino C. PMID: 3980369.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    40. Enhancement of ozone-induced lung injury by exercise. J Toxicol Environ Health. 1985; 16(6):841-54. Mautz WJ, McClure TR, Reischl P, Phalen RF, Crocker TT. PMID: 4093997.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    41. Inhalation exposure methodology. Environ Health Perspect. 1984 Jun; 56:23-34. Phalen RF, Mannix RC, Drew RT. PMID: 6383799; PMCID: PMC1568202.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    42. Effects of sulfur dioxide and formaldehyde on particle clearance in the rat. J Toxicol Environ Health. 1983 Aug-Sep; 12(2-3):429-40. Mannix RC, Phalen RF, Walters RB, Kurosaki TT. PMID: 6655744.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    43. Tracheobronchial airway structure as revealed by casting techniques. Am Rev Respir Dis. 1983 Aug; 128(2 Pt 2):S1-4. Phalen RF, Oldham MJ. PMID: 6881699.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    44. Effect of sulfur dioxide-sulfate exposure on rat respiratory tract clearance. Am Ind Hyg Assoc J. 1982 Sep; 43(9):679-85. Mannix RC, Phalen RF, Kenoyer JL, Crocker TT. PMID: 7148689.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsPHPublic Health
    45. An airway perfusion apparatus for whole lung fixation. Lab Anim Sci. 1982 Apr; 32(2):195-6. McClure TR, Diller PJ, Phalen RF. PMID: 7078090.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    46. Growth rate measurements and deposition modelling of hygroscopic aerosols in human tracheobronchial models. Ann Occup Hyg. 1982; 26(1-4):93-108. Martonen TB, Bell KA, Phalen RF, Wilson AF, Ho A. PMID: 7181315.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    47. Implications of the dosimetric model for the respiratory system on limits for intakes of radionuclides by workers (ICRP Publication 30). Ann Occup Hyg. 1982; 26(1-4):163-76. Craig DK, Brain JD, Cuddihy RG, Kanapilly G, Phalen RF, Swift DL, Stuart BO. PMID: 7181263.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    48. Particle clearance from the respiratory tract as a test of toxicity: effect of ozone on short and long term clearance. Exp Lung Res. 1981 May; 2(2):111-20. Kenoyer JL, Phalen RF, Davis JR. PMID: 7274176.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    49. Effect of in vivo ozone exposure on in vitro pulmonary alveolar macrophage mobility. J Toxicol Environ Health. 1981 Mar-Apr; 7(3-4):373-81. McAllen SJ, Chiu SP, Phalen RF, Rasmussen RE. PMID: 7288893.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    50. Effects of sulfate aerosols in combination with ozone on elimination of tracer particles inhaled by rats. J Toxicol Environ Health. 1980 Jul; 6(4):797-810. Phalen RF, Kenoyer JL, Crocker TT, McClure TR. PMID: 7420482.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    51. Laboratory production of ammonium and ferric sulfate aerosols. Am Ind Hyg Assoc J. 1980 May; 41(5):346-51. Ho AT, Phalen RF, Crocker TT. PMID: 7415961.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    52. A latex-sponge collar for partial-body plethysmography using anesthetized rodents. Lab Anim Sci. 1979 Oct; 29(5):652-5. Esparza DC, Schum GM, Phalen RF. PMID: 513636.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    53. Adaptations to ozone in reference to mucociliary clearance. Arch Environ Health. 1979 Jan-Feb; 34(1):51-7. Frager NB, Phalen RF, Kenoyer JL. PMID: 434928.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    54. Labeling of monodisperse polystyrene microspheres with tightly bound 51Cr. Am Ind Hyg Assoc J. 1978 Jul; 39(7):570-5. Hinrichs RJ, Kenoyer JL, Phalen RF, Crocker TT. PMID: 696612.
      View in: PubMed   Mentions: 1     Fields:    
    55. Influence of steroid aerosol treatments on the clearance of inhaled gold particles. Steroids. 1978 Jun; 31(6):761-9. Elliot JC, Phalen RF. PMID: 694965.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    56. Application of an idealized model to morphometry of the mammalian tracheobronchial tree. Anat Rec. 1978 Feb; 190(2):167-76. Phalen RF, Yeh HC, Schum GM, Raabe OG. PMID: 629400.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    57. Inhalation exposure of animals. Environ Health Perspect. 1976 Aug; 16:17-24. Phalen RF. PMID: 1017420; PMCID: PMC1475216.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsPHPublic Health
    58. Factors influencing the deposition of inhaled particles. Environ Health Perspect. 1976 Jun; 15:147-56. Yeh HC, Phalen RF, Raabe OG. PMID: 1001293; PMCID: PMC1475169.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    59. Deposition of inhaled monodisperse aerosols in small rodents. Inhaled Part. 1975 Sep; 4 Pt 1:3-21. Raab OG, Yeh HC, Newton GJ, Phalen RF, Velasquez DJ. PMID: 1236165.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    60. A stereoradiographic technique and its application to the evaluation of lung casts. Invest Radiol. 1975 Jul-Aug; 10(4):351-7. Yeh HC, Hulbert AJ, Phalen RF, Velasquez DJ, Harris TD. PMID: 1184324.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    61. Casting the lungs In-situ. Anat Rec. 1973 Oct; 177(2):255-63. Phalen RF, Yeh HC, Raabe OG, Velasquez DJ. PMID: 4756760.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    62. Experimental inhalation of metallic silver. Health Phys. 1973 May; 24(5):509-18. Phalen RF, Morrow PE. PMID: 4707665.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
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