Rami Khayat

Title(s)Professor of Clinical Medicine, Medicine
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
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    1. A mathematical model to serve as a clinical tool for assessing obstructive sleep apnea severity. Front Physiol. 2023; 14:1198132. Qayyum NT, Wallace CH, Khayat RN, Grosberg A. PMID: 37601632; PMCID: PMC10434550.
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    2. Breathe Better and Preserve Heart. J Am Heart Assoc. 2023 07 18; 12(14):e030806. Healy WJ, Khayat R, Kwon Y. PMID: 37421298; PMCID: PMC10382111.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Clinical and financial impact of sleep disordered breathing on heart failure admissions. Sleep Breath. 2023 10; 27(5):1917-1924. Khayat RN, Porter K, Germany RE, McKane SW, Healy W, Randerath W. PMID: 36930416; PMCID: PMC10539452.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. Adaptive servo-ventilation and mortality in patients with systolic heart failure and central sleep apnea: a single-center experience. Sleep Breath. 2023 10; 27(5):1909-1915. Sun P, Porter K, Randerath W, Jarjoura D, Khayat R. PMID: 36920657; PMCID: PMC10539434.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Reducing disparities in cardiovascular health in African Americans through integrated cardiovascular sleep care in outpatient setting. Sleep Adv. 2022; 3(1):zpac016. Healy WJ, Jean-Louis G, Yancy CW, Billings ME, Khayat R, Kwon Y. PMID: 37193403; PMCID: PMC10104406.
      View in: PubMed   Mentions:
    6. Pathways of Microcirculatory Endothelial Dysfunction in Obstructive Sleep Apnea: A Comprehensive Ex Vivo Evaluation in Human Tissue. Am J Hypertens. 2022 04 02; 35(4):347-355. Gavrilin MA, Porter K, Samouilov A, Khayat RN. PMID: 34694354; PMCID: PMC8976176.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. Transvenous Phrenic Nerve Stimulation for Central Sleep Apnea: Clinical and Billing Review. Chest. 2022 05; 161(5):1330-1337. Teckchandani PH, Truong KK, Zezoff D, Healy WJ, Khayat RN. PMID: 34808108; PMCID: PMC9131046.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Central sleep apnea treatment in patients with heart failure with reduced ejection fraction: a network meta-analysis. Sleep Breath. 2022 09; 26(3):1227-1235. Iftikhar IH, Khayat RN. PMID: 34698980.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Research Priorities for Patients with Heart Failure and Central Sleep Apnea. An Official American Thoracic Society Research Statement. Am J Respir Crit Care Med. 2021 03 15; 203(6):e11-e24. Orr JE, Ayappa I, Eckert DJ, Feldman JL, Jackson CL, Javaheri S, Khayat RN, Martin JL, Mehra R, Naughton MT, Randerath WJ, Sands SA, Somers VK, Badr MS. PMID: 33719931; PMCID: PMC7958519.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    10. Mixed Apnea Metrics in Obstructive Sleep Apnea Predict Treatment-Emergent Central Sleep Apnea. Am J Respir Crit Care Med. 2021 03 15; 203(6):772-775. Pavsic K, Herkenrath S, Treml M, Hagmeyer L, Khayat RN, Hellmich M, Randerath WJ. PMID: 33233936.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    11. A 17-Year-Old With Becker Muscular Dystrophy and Unusual Polysomnography Findings. Chest. 2021 01; 159(1):e19-e23. Paul GR, Khayat RN, Kotha K, Nandi D, Cripe L, Shell R. PMID: 33422235.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Corrigendum to "Meta-Analysis Comparing Outcomes of Therapies for Patients with Central Sleep Apnea and Heart Failure With Reduced Ejection Fraction". Am J Cardiol. 2020 Nov 01; 134:162. Voigt J, Emani S, Gupta S, Germany R, Khayat R. PMID: 32919618.
      View in: PubMed   Mentions:    Fields:    
    13. In-Hospital Management of Sleep Apnea During Heart Failure Hospitalization: A Randomized Controlled Trial. J Card Fail. 2020 Aug; 26(8):705-712. Khayat RN, Javaheri S, Porter K, Sow A, Holt R, Randerath W, Abraham WT, Jarjoura D. PMID: 32592897; PMCID: PMC7484161.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    14. Meta-Analysis Comparing Outcomes of Therapies for Patients With Central Sleep Apnea and Heart Failure With Reduced Ejection Fraction. Am J Cardiol. 2020 07 15; 127:73-83. Voigt J, Emani S, Gupta S, Germany R, Khayat R. PMID: 32430162.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    15. Update on Apneas of Heart Failure With Reduced Ejection Fraction: Emphasis on the Physiology of Treatment: Part 2: Central Sleep Apnea. Chest. 2020 06; 157(6):1637-1646. Javaheri S, Brown LK, Khayat RN. PMID: 31958442.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    16. Apneas of Heart Failure and Phenotype-Guided Treatments: Part One: OSA. Chest. 2020 02; 157(2):394-402. Javaheri S, Brown LK, Abraham WT, Khayat R. PMID: 31047953; PMCID: PMC7005380.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    17. Phrenic nerve stimulation to treat patients with central sleep apnoea and heart failure. Eur J Heart Fail. 2018 12; 20(12):1746-1754. Costanzo MR, Ponikowski P, Coats A, Javaheri S, Augostini R, Goldberg LR, Holcomb R, Kao A, Khayat RN, Oldenburg O, Stellbrink C, McKane S, Abraham WT, remede® System Pivotal Trial Study Group. PMID: 30303611; PMCID: PMC6607512.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    18. Rebuttal to Naughton. J Clin Sleep Med. 2018 06 15; 14(6):923-925. Javaheri S, Brown LK, Khayat R. PMID: 29852919; PMCID: PMC5991955.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. CON: Persistent Central Sleep Apnea/Hunter-Cheyne-Stokes Breathing, Despite Best Guideline-Based Therapy of Heart Failure With Reduced Ejection Fraction, Is Not a Compensatory Mechanism and Should Be Suppressed. J Clin Sleep Med. 2018 06 15; 14(6):915-921. Javaheri S, Brown LK, Khayat R. PMID: 29852913; PMCID: PMC5991943.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    20. Sustained 12 Month Benefit of Phrenic Nerve Stimulation for Central Sleep Apnea. Am J Cardiol. 2018 06 01; 121(11):1400-1408. Costanzo MR, Ponikowski P, Javaheri S, Augostini R, Goldberg LR, Holcomb R, Kao A, Khayat RN, Oldenburg O, Stellbrink C, Abraham WT, remede System Pivotal Trial Study Group. PMID: 29735217.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    21. Sleep Apnea in Heart Failure. Curr Treat Options Cardiovasc Med. 2018 Mar 22; 20(4):33. Tsai M, Khayat R. PMID: 29568980.
      View in: PubMed   Mentions: 9  
    22. Angiotensin Receptor Expression and Vascular Endothelial Dysfunction in Obstructive Sleep Apnea. Am J Hypertens. 2018 02 09; 31(3):355-361. Khayat RN, Varadharaj S, Porter K, Sow A, Jarjoura D, Gavrilin MA, Zweier JL. PMID: 29036393; PMCID: PMC5861541.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    23. Role of Dietary Antioxidants in the Preservation of Vascular Function and the Modulation of Health and Disease. Front Cardiovasc Med. 2017; 4:64. Varadharaj S, Kelly OJ, Khayat RN, Kumar PS, Ahmed N, Zweier JL. PMID: 29164133; PMCID: PMC5671956.
      View in: PubMed   Mentions: 22  
    24. Adaptive servoventilation in clinical practice: beyond SERVE-HF? ERJ Open Res. 2017 Oct; 3(4). Randerath W, Schumann K, Treml M, Herkenrath S, Castrogiovanni A, Javaheri S, Khayat R. PMID: 29204433; PMCID: PMC5703354.
      View in: PubMed   Mentions: 3  
    25. Sleep and the Heart: What's Next? Sleep Med Clin. 2017 06; 12(2):xiii-xiv. Khayat RN. PMID: 28477780.
      View in: PubMed   Mentions:    Fields:    
    26. A Practical Approach to the Identification and Management of Sleep-Disordered Breathing in Heart Failure Patients. Sleep Med Clin. 2017 Jun; 12(2):205-219. Kahwash R, Khayat RN. PMID: 28477775.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    27. Sleep Apnea: Types, Mechanisms, and Clinical Cardiovascular Consequences. J Am Coll Cardiol. 2017 Feb 21; 69(7):841-858. Javaheri S, Barbe F, Campos-Rodriguez F, Dempsey JA, Khayat R, Javaheri S, Malhotra A, Martinez-Garcia MA, Mehra R, Pack AI, Polotsky VY, Redline S, Somers VK. PMID: 28209226; PMCID: PMC5393905.
      View in: PubMed   Mentions: 367     Fields:    Translation:Humans
    28. Snoring in the Morning Light. J Clin Sleep Med. 2016 12 15; 12(12):1581-1582. Khayat RN, Jafari B. PMID: 27855747; PMCID: PMC5155188.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    29. Consequences of Obstructive Sleep Apnea: Cardiovascular Risk of Obstructive Sleep Apnea and Whether Continuous Positive Airway Pressure Reduces that Risk. Sleep Med Clin. 2016 Sep; 11(3):273-86. Khayat R, Pleister A. PMID: 27542874.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    30. Transvenous neurostimulation for central sleep apnoea: a randomised controlled trial. Lancet. 2016 Sep 03; 388(10048):974-82. Costanzo MR, Ponikowski P, Javaheri S, Augostini R, Goldberg L, Holcomb R, Kao A, Khayat RN, Oldenburg O, Stellbrink C, Abraham WT, remedé System Pivotal Trial Study Group. PMID: 27598679.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    31. Transvenous stimulation of the phrenic nerve for the treatment of central sleep apnoea: 12 months' experience with the remedē® System. Eur J Heart Fail. 2016 11; 18(11):1386-1393. Jagielski D, Ponikowski P, Augostini R, Kolodziej A, Khayat R, Abraham WT. PMID: 27373452.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    32. Current treatment approaches and trials in central sleep apnea. Int J Cardiol. 2016 Mar; 206 Suppl:S22-7. Khayat RN, Abraham WT. PMID: 26961738.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    33. SERVE-HF: More Questions Than Answers. Chest. 2016 Apr; 149(4):900-4. Javaheri S, Brown LK, Randerath W, Khayat R. PMID: 26836904.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    34. Missing links. Sleep Med. 2015 Dec; 16(12):1495-6. Randerath W, Khayat R, Arzt M, Javaheri S. PMID: 26611946.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    35. Are Mindfulness and Self-Compassion Associated with Sleep and Resilience in Health Professionals? J Altern Complement Med. 2015 Aug; 21(8):496-503. Kemper KJ, Mo X, Khayat R. PMID: 26218885; PMCID: PMC4523072.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    36. Phrenic nerve stimulation for the treatment of central sleep apnea. JACC Heart Fail. 2015 May; 3(5):360-369. Abraham WT, Jagielski D, Oldenburg O, Augostini R, Krueger S, Kolodziej A, Gutleben KJ, Khayat R, Merliss A, Harsch MR, Holcomb RG, Javaheri S, Ponikowski P, remede Pilot Study Investigators. PMID: 25770408.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCTClinical Trials
    37. Sleep disordered breathing and post-discharge mortality in patients with acute heart failure. Eur Heart J. 2015 Jun 14; 36(23):1463-9. Khayat R, Jarjoura D, Porter K, Sow A, Wannemacher J, Dohar R, Pleister A, Abraham WT. PMID: 25636743; PMCID: PMC4465635.
      View in: PubMed   Mentions: 78     Fields:    Translation:Humans
    38. Mechanisms and clinical consequences of untreated central sleep apnea in heart failure. J Am Coll Cardiol. 2015 Jan 06; 65(1):72-84. Costanzo MR, Khayat R, Ponikowski P, Augostini R, Stellbrink C, Mianulli M, Abraham WT. PMID: 25572513; PMCID: PMC4391015.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    39. Endothelial nitric oxide synthase uncoupling: a novel pathway in OSA induced vascular endothelial dysfunction. Respir Physiol Neurobiol. 2015 Feb 01; 207:40-7. Varadharaj S, Porter K, Pleister A, Wannemacher J, Sow A, Jarjoura D, Zweier JL, Khayat RN. PMID: 25534145; PMCID: PMC4297730.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    40. Obstructive sleep apnea and atrial fibrillation: understanding the connection. Expert Rev Cardiovasc Ther. 2014 May; 12(5):613-21. Oza N, Baveja S, Khayat R, Houmsse M. PMID: 24731146.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansPHPublic Health
    41. Sleep-disordered breathing in heart failure: identifying and treating an important but often unrecognized comorbidity in heart failure patients. J Card Fail. 2013 Jun; 19(6):431-44. Khayat R, Small R, Rathman L, Krueger S, Gocke B, Clark L, Yamokoski L, Abraham WT. PMID: 23743494; PMCID: PMC3690313.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    42. Issues applying a math model to estimate continuous positive airway pressure response in Cheyne-Stokes respiration. Am J Respir Crit Care Med. 2013 Mar 01; 187(5):553. Campbell L, Best J, Khayat R, Splaingard M. PMID: 23457367.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    43. Central sleep apnea is a predictor of cardiac readmission in hospitalized patients with systolic heart failure. J Card Fail. 2012 Jul; 18(7):534-40. Khayat R, Abraham W, Patt B, Brinkman V, Wannemacher J, Porter K, Jarjoura D. PMID: 22748486; PMCID: PMC3482612.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    44. The performance of two automatic servo-ventilation devices in the treatment of central sleep apnea. Sleep. 2011 Dec 01; 34(12):1693-8. Javaheri S, Goetting MG, Khayat R, Wylie PE, Goodwin JL, Parthasarathy S. PMID: 22131607; PMCID: PMC3208847.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    45. Transvenous phrenic nerve stimulation for the treatment of central sleep apnoea in heart failure. Eur Heart J. 2012 Apr; 33(7):889-94. Ponikowski P, Javaheri S, Michalkiewicz D, Bart BA, Czarnecka D, Jastrzebski M, Kusiak A, Augostini R, Jagielski D, Witkowski T, Khayat RN, Oldenburg O, Gutleben KJ, Bitter T, Karim R, Iber C, Hasan A, Hibler K, Germany R, Abraham WT. PMID: 21856678; PMCID: PMC3345560.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    46. Recognition and management of sleep-disordered breathing in chronic heart failure. Curr Heart Fail Rep. 2011 Mar; 8(1):72-9. Kahwash R, Kikta D, Khayat R. PMID: 21086079; PMCID: PMC3696518.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    47. Prevalence of obstructive sleep apnea in patients with chronic wounds. J Clin Sleep Med. 2010 Dec 15; 6(6):541-4. Patt BT, Jarjoura D, Lambert L, Roy S, Gordillo G, Schlanger R, Sen CK, Khayat RN. PMID: 21206743; PMCID: PMC3014239.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    48. Endothelial dysfunction in the microcirculation of patients with obstructive sleep apnea. Am J Respir Crit Care Med. 2010 Dec 15; 182(12):1540-5. Patt BT, Jarjoura D, Haddad DN, Sen CK, Roy S, Flavahan NA, Khayat RN. PMID: 20656942; PMCID: PMC3029939.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    49. In-hospital treatment of obstructive sleep apnea during decompensation of heart failure. Chest. 2009 Oct; 136(4):991-997. Khayat RN, Abraham WT, Patt B, Pu M, Jarjoura D. PMID: 19567491; PMCID: PMC2771043.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    50. In-hospital testing for sleep-disordered breathing in hospitalized patients with decompensated heart failure: report of prevalence and patient characteristics. J Card Fail. 2009 Nov; 15(9):739-46. Khayat RN, Jarjoura D, Patt B, Yamokoski T, Abraham WT. PMID: 19879459; PMCID: PMC2772830.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    51. Hypertension in obstructive sleep apnea: risk and therapy. Expert Rev Cardiovasc Ther. 2009 Jun; 7(6):619-26. Das AM, Khayat R. PMID: 19505277.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    52. Obstructive sleep apnea: the new cardiovascular disease. Part I: Obstructive sleep apnea and the pathogenesis of vascular disease. Heart Fail Rev. 2009 Sep; 14(3):143-53. Khayat R, Patt B, Hayes D. PMID: 18807180; PMCID: PMC2698951.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    53. OSA: the new cardiovascular disease: part II: Overview of cardiovascular diseases associated with obstructive sleep apnea. Heart Fail Rev. 2009 Sep; 14(3):155-64. Devulapally K, Pongonis R, Khayat R. PMID: 18758946; PMCID: PMC2698954.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    54. Sleep-disordered breathing in patients with decompensated heart failure. Heart Fail Rev. 2009 Sep; 14(3):183-93. Valdivia-Arenas MA, Powers M, Khayat RN. PMID: 18758944; PMCID: PMC2698948.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    55. Cardiac effects of continuous and bilevel positive airway pressure for patients with heart failure and obstructive sleep apnea: a pilot study. Chest. 2008 Dec; 134(6):1162-1168. Khayat RN, Abraham WT, Patt B, Roy M, Hua K, Jarjoura D. PMID: 18641111; PMCID: PMC2757406.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    56. An asian woman with eosinophilia and bilateral pulmonary infiltrates. Respiration. 2007; 74(2):224-7. Valdivia-Arenas MA, Khayat R. PMID: 17003525.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    57. Influence of cerebrovascular function on the hypercapnic ventilatory response in healthy humans. J Physiol. 2006 Nov 15; 577(Pt 1):319-29. Xie A, Skatrud JB, Morgan B, Chenuel B, Khayat R, Reichmuth K, Lin J, Dempsey JA. PMID: 16931556; PMCID: PMC2000684.
      View in: PubMed   Mentions: 62     Fields:    Translation:Humans
    58. Cerebrovascular response to carbon dioxide in patients with congestive heart failure. Am J Respir Crit Care Med. 2005 Aug 01; 172(3):371-8. Xie A, Skatrud JB, Khayat R, Dempsey JA, Morgan B, Russell D. PMID: 15901613.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    59. Role of sensory input from the lungs in control of muscle sympathetic nerve activity during and after apnea in humans. J Appl Physiol (1985). 2004 Aug; 97(2):635-40. Khayat RN, Przybylowski T, Meyer KC, Skatrud JB, Morgan BJ. PMID: 15075300.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    60. Baroreflex-induced sympathetic activation does not alter cerebrovascular CO2 responsiveness in humans. J Physiol. 2003 Sep 01; 551(Pt 2):609-16. LeMarbre G, Stauber S, Khayat RN, Puleo DS, Skatrud JB, Morgan BJ. PMID: 12844511; PMCID: PMC2343219.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCTClinical Trials
    61. Cardiorespiratory effects of added dead space in patients with heart failure and central sleep apnea. Chest. 2003 May; 123(5):1551-60. Khayat RN, Xie A, Patel AK, Kaminski A, Skatrud JB. PMID: 12740273.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    62. A T14C variant of Azotobacter vinelandii ferredoxin I undergoes facile [3Fe-4S]0 to [4Fe-4S]2+ conversion in vitro but not in vivo. J Biol Chem. 1998 Dec 11; 273(50):33692-701. Gao-Sheridan HS, Kemper MA, Khayat R, Tilley GJ, Armstrong FA, Sridhar V, Prasad GS, Stout CD, Burgess BK. PMID: 9837955.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
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