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Pathways of Microcirculatory Endothelial Dysfunction in Obstructive Sleep Apnea: A Comprehensive Ex Vivo Evaluation in Human Tissue. Am J Hypertens. 2022 04 02; 35(4):347-355.
Gavrilin MA, Porter K, Samouilov A, Khayat RN. PMID: 34694354; PMCID: PMC8976176.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Transvenous Phrenic Nerve Stimulation for Central Sleep Apnea: Clinical and Billing Review. Chest. 2022 05; 161(5):1330-1337.
Teckchandani PH, Truong KK, Zezoff D, Healy WJ, Khayat RN. PMID: 34808108; PMCID: PMC9131046.
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PubMed Mentions: Fields:
Translation:
Humans
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Central sleep apnea treatment in patients with heart failure with reduced ejection fraction: a network meta-analysis. Sleep Breath. 2022 09; 26(3):1227-1235.
Iftikhar IH, Khayat RN. PMID: 34698980.
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PubMed Mentions: Fields:
Translation:
Humans
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Mixed Apnea Metrics in Obstructive Sleep Apnea Predict Treatment-Emergent Central Sleep Apnea. Am J Respir Crit Care Med. 2021 03 15; 203(6):772-775.
Pavsic K, Herkenrath S, Treml M, Hagmeyer L, Khayat RN, Hellmich M, Randerath WJ. PMID: 33233936.
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PubMed Mentions:
6 Fields:
Translation:
Humans
-
Research Priorities for Patients with Heart Failure and Central Sleep Apnea. An Official American Thoracic Society Research Statement. Am J Respir Crit Care Med. 2021 03 15; 203(6):e11-e24.
Orr JE, Ayappa I, Eckert DJ, Feldman JL, Jackson CL, Javaheri S, Khayat RN, Martin JL, Mehra R, Naughton MT, Randerath WJ, Sands SA, Somers VK, Badr MS. PMID: 33719931; PMCID: PMC7958519.
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PubMed Mentions:
13 Fields:
Translation:
Humans
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A 17-Year-Old With Becker Muscular Dystrophy and Unusual Polysomnography Findings. Chest. 2021 01; 159(1):e19-e23.
Paul GR, Khayat RN, Kotha K, Nandi D, Cripe L, Shell R. PMID: 33422235.
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PubMed Mentions: Fields:
Translation:
Humans
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Corrigendum to "Meta-Analysis Comparing Outcomes of Therapies for Patients with Central Sleep Apnea and Heart Failure With Reduced Ejection Fraction". Am J Cardiol. 2020 Nov 01; 134:162.
Voigt J, Emani S, Gupta S, Germany R, Khayat R. PMID: 32919618.
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PubMed Mentions: Fields:
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In-Hospital Management of Sleep Apnea During Heart Failure Hospitalization: A Randomized Controlled Trial. J Card Fail. 2020 Aug; 26(8):705-712.
Khayat RN, Javaheri S, Porter K, Sow A, Holt R, Randerath W, Abraham WT, Jarjoura D. PMID: 32592897; PMCID: PMC7484161.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Meta-Analysis Comparing Outcomes of Therapies for Patients With Central Sleep Apnea and Heart Failure With Reduced Ejection Fraction. Am J Cardiol. 2020 07 15; 127:73-83.
Voigt J, Emani S, Gupta S, Germany R, Khayat R. PMID: 32430162.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Update on Apneas of Heart Failure With Reduced Ejection Fraction: Emphasis on the Physiology of Treatment: Part 2: Central Sleep Apnea. Chest. 2020 06; 157(6):1637-1646.
Javaheri S, Brown LK, Khayat RN. PMID: 31958442.
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PubMed Mentions:
4 Fields:
Translation:
Humans
-
Apneas of Heart Failure and Phenotype-Guided Treatments: Part One: OSA. Chest. 2020 02; 157(2):394-402.
Javaheri S, Brown LK, Abraham WT, Khayat R. PMID: 31047953; PMCID: PMC7005380.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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Phrenic nerve stimulation to treat patients with central sleep apnoea and heart failure. Eur J Heart Fail. 2018 12; 20(12):1746-1754.
Costanzo MR, Ponikowski P, Coats A, Javaheri S, Augostini R, Goldberg LR, Holcomb R, Kao A, Khayat RN, Oldenburg O, Stellbrink C, McKane S, Abraham WT, remede? System Pivotal Trial Study Group. PMID: 30303611; PMCID: PMC6607512.
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PubMed Mentions:
20 Fields:
Translation:
Humans
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CON: Persistent Central Sleep Apnea/Hunter-Cheyne-Stokes Breathing, Despite Best Guideline-Based Therapy of Heart Failure With Reduced Ejection Fraction, Is Not a Compensatory Mechanism and Should Be Suppressed. J Clin Sleep Med. 2018 06 15; 14(6):915-921.
Javaheri S, Brown LK, Khayat R. PMID: 29852913; PMCID: PMC5991943.
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PubMed Mentions:
9 Fields:
Translation:
Humans
-
Rebuttal to Naughton. J Clin Sleep Med. 2018 06 15; 14(6):923-925.
Javaheri S, Brown LK, Khayat R. PMID: 29852919; PMCID: PMC5991955.
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PubMed Mentions:
1 Fields:
Translation:
Humans
-
Sustained 12 Month Benefit of Phrenic Nerve Stimulation for Central Sleep Apnea. Am J Cardiol. 2018 06 01; 121(11):1400-1408.
Costanzo MR, Ponikowski P, Javaheri S, Augostini R, Goldberg LR, Holcomb R, Kao A, Khayat RN, Oldenburg O, Stellbrink C, Abraham WT, remede System Pivotal Trial Study Group. PMID: 29735217.
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PubMed Mentions:
11 Fields:
Translation:
Humans
-
Sleep Apnea in Heart Failure. Curr Treat Options Cardiovasc Med. 2018 Mar 22; 20(4):33.
Tsai M, Khayat R. PMID: 29568980.
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PubMed Mentions:
7
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Angiotensin Receptor Expression and Vascular Endothelial Dysfunction in Obstructive Sleep Apnea. Am J Hypertens. 2018 02 09; 31(3):355-361.
Khayat RN, Varadharaj S, Porter K, Sow A, Jarjoura D, Gavrilin MA, Zweier JL. PMID: 29036393; PMCID: PMC5861541.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Role of Dietary Antioxidants in the Preservation of Vascular Function and the Modulation of Health and Disease. Front Cardiovasc Med. 2017; 4:64.
Varadharaj S, Kelly OJ, Khayat RN, Kumar PS, Ahmed N, Zweier JL. PMID: 29164133; PMCID: PMC5671956.
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PubMed Mentions:
21
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Adaptive servoventilation in clinical practice: beyond SERVE-HF? ERJ Open Res. 2017 Oct; 3(4).
Randerath W, Schumann K, Treml M, Herkenrath S, Castrogiovanni A, Javaheri S, Khayat R. PMID: 29204433; PMCID: PMC5703354.
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PubMed Mentions:
2
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Sleep and the Heart: What's Next? Sleep Med Clin. 2017 06; 12(2):xiii-xiv.
Khayat RN. PMID: 28477780.
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PubMed Mentions: Fields:
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A Practical Approach to the Identification and Management of Sleep-Disordered Breathing in Heart Failure Patients. Sleep Med Clin. 2017 Jun; 12(2):205-219.
Kahwash R, Khayat RN. PMID: 28477775.
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PubMed Mentions:
1 Fields:
Translation:
Humans
-
Sleep Apnea: Types, Mechanisms, and Clinical Cardiovascular Consequences. J Am Coll Cardiol. 2017 Feb 21; 69(7):841-858.
Javaheri S, Barbe F, Campos-Rodriguez F, Dempsey JA, Khayat R, Javaheri S, Malhotra A, Martinez-Garcia MA, Mehra R, Pack AI, Polotsky VY, Redline S, Somers VK. PMID: 28209226; PMCID: PMC5393905.
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PubMed Mentions:
313 Fields:
Translation:
Humans
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Snoring in the Morning Light. J Clin Sleep Med. 2016 12 15; 12(12):1581-1582.
Khayat RN, Jafari B. PMID: 27855747; PMCID: PMC5155188.
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PubMed Mentions: Fields:
Translation:
Humans
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Consequences of Obstructive Sleep Apnea: Cardiovascular Risk of Obstructive Sleep Apnea and Whether Continuous Positive Airway Pressure Reduces that Risk. Sleep Med Clin. 2016 Sep; 11(3):273-86.
Khayat R, Pleister A. PMID: 27542874.
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PubMed Mentions:
18 Fields:
Translation:
Humans
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Transvenous neurostimulation for central sleep apnoea: a randomised controlled trial. Lancet. 2016 Sep 03; 388(10048):974-82.
Costanzo MR, Ponikowski P, Javaheri S, Augostini R, Goldberg L, Holcomb R, Kao A, Khayat RN, Oldenburg O, Stellbrink C, Abraham WT, remed? System Pivotal Trial Study Group. PMID: 27598679.
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PubMed Mentions:
43 Fields:
Translation:
Humans
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Transvenous stimulation of the phrenic nerve for the treatment of central sleep apnoea: 12 months' experience with the remede� System. Eur J Heart Fail. 2016 11; 18(11):1386-1393.
Jagielski D, Ponikowski P, Augostini R, Kolodziej A, Khayat R, Abraham WT. PMID: 27373452.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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Current treatment approaches and trials in central sleep apnea. Int J Cardiol. 2016 Mar; 206 Suppl:S22-7.
Khayat RN, Abraham WT. PMID: 26961738.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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SERVE-HF: More Questions Than Answers. Chest. 2016 Apr; 149(4):900-4.
Javaheri S, Brown LK, Randerath W, Khayat R. PMID: 26836904.
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PubMed Mentions:
34 Fields:
Translation:
Humans
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Missing links. Sleep Med. 2015 Dec; 16(12):1495-6.
Randerath W, Khayat R, Arzt M, Javaheri S. PMID: 26611946.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Are Mindfulness and Self-Compassion Associated with Sleep and Resilience in Health Professionals? J Altern Complement Med. 2015 Aug; 21(8):496-503.
Kemper KJ, Mo X, Khayat R. PMID: 26218885; PMCID: PMC4523072.
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PubMed Mentions:
49 Fields:
Translation:
Humans
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Phrenic nerve stimulation for the treatment of central sleep apnea. JACC Heart Fail. 2015 May; 3(5):360-369.
Abraham WT, Jagielski D, Oldenburg O, Augostini R, Krueger S, Kolodziej A, Gutleben KJ, Khayat R, Merliss A, Harsch MR, Holcomb RG, Javaheri S, Ponikowski P, remede Pilot Study Investigators. PMID: 25770408.
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PubMed Mentions:
28 Fields:
Translation:
HumansCTClinical Trials
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Sleep disordered breathing and post-discharge mortality in patients with acute heart failure. Eur Heart J. 2015 Jun 14; 36(23):1463-9.
Khayat R, Jarjoura D, Porter K, Sow A, Wannemacher J, Dohar R, Pleister A, Abraham WT. PMID: 25636743; PMCID: PMC4465635.
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PubMed Mentions:
67 Fields:
Translation:
Humans
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Mechanisms and clinical consequences of untreated central sleep apnea in heart failure. J Am Coll Cardiol. 2015 Jan 06; 65(1):72-84.
Costanzo MR, Khayat R, Ponikowski P, Augostini R, Stellbrink C, Mianulli M, Abraham WT. PMID: 25572513; PMCID: PMC4391015.
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PubMed Mentions:
33 Fields:
Translation:
Humans
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Endothelial nitric oxide synthase uncoupling: a novel pathway in OSA induced vascular endothelial dysfunction. Respir Physiol Neurobiol. 2015 Feb 01; 207:40-7.
Varadharaj S, Porter K, Pleister A, Wannemacher J, Sow A, Jarjoura D, Zweier JL, Khayat RN. PMID: 25534145; PMCID: PMC4297730.
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PubMed Mentions:
23 Fields:
Translation:
Humans
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Obstructive sleep apnea and atrial fibrillation: understanding the connection. Expert Rev Cardiovasc Ther. 2014 May; 12(5):613-21.
Oza N, Baveja S, Khayat R, Houmsse M. PMID: 24731146.
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PubMed Mentions:
9 Fields:
Translation:
HumansPHPublic Health
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Sleep-disordered breathing in heart failure: identifying and treating an important but often unrecognized comorbidity in heart failure patients. J Card Fail. 2013 Jun; 19(6):431-44.
Khayat R, Small R, Rathman L, Krueger S, Gocke B, Clark L, Yamokoski L, Abraham WT. PMID: 23743494; PMCID: PMC3690313.
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PubMed Mentions:
15 Fields:
Translation:
Humans
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Issues applying a math model to estimate continuous positive airway pressure response in Cheyne-Stokes respiration. Am J Respir Crit Care Med. 2013 Mar 01; 187(5):553.
Campbell L, Best J, Khayat R, Splaingard M. PMID: 23457367.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
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Central sleep apnea is a predictor of cardiac readmission in hospitalized patients with systolic heart failure. J Card Fail. 2012 Jul; 18(7):534-40.
Khayat R, Abraham W, Patt B, Brinkman V, Wannemacher J, Porter K, Jarjoura D. PMID: 22748486; PMCID: PMC3482612.
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PubMed Mentions:
45 Fields:
Translation:
Humans
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The performance of two automatic servo-ventilation devices in the treatment of central sleep apnea. Sleep. 2011 Dec 01; 34(12):1693-8.
Javaheri S, Goetting MG, Khayat R, Wylie PE, Goodwin JL, Parthasarathy S. PMID: 22131607; PMCID: PMC3208847.
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PubMed Mentions:
16 Fields:
Translation:
Humans
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Transvenous phrenic nerve stimulation for the treatment of central sleep apnoea in heart failure. Eur Heart J. 2012 Apr; 33(7):889-94.
Ponikowski P, Javaheri S, Michalkiewicz D, Bart BA, Czarnecka D, Jastrzebski M, Kusiak A, Augostini R, Jagielski D, Witkowski T, Khayat RN, Oldenburg O, Gutleben KJ, Bitter T, Karim R, Iber C, Hasan A, Hibler K, Germany R, Abraham WT. PMID: 21856678; PMCID: PMC3345560.
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PubMed Mentions:
35 Fields:
Translation:
Humans
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Recognition and management of sleep-disordered breathing in chronic heart failure. Curr Heart Fail Rep. 2011 Mar; 8(1):72-9.
Kahwash R, Kikta D, Khayat R. PMID: 21086079; PMCID: PMC3696518.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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Prevalence of obstructive sleep apnea in patients with chronic wounds. J Clin Sleep Med. 2010 Dec 15; 6(6):541-4.
Patt BT, Jarjoura D, Lambert L, Roy S, Gordillo G, Schlanger R, Sen CK, Khayat RN. PMID: 21206743; PMCID: PMC3014239.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Endothelial dysfunction in the microcirculation of patients with obstructive sleep apnea. Am J Respir Crit Care Med. 2010 Dec 15; 182(12):1540-5.
Patt BT, Jarjoura D, Haddad DN, Sen CK, Roy S, Flavahan NA, Khayat RN. PMID: 20656942; PMCID: PMC3029939.
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PubMed Mentions:
36 Fields:
Translation:
Humans
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In-hospital treatment of obstructive sleep apnea during decompensation of heart failure. Chest. 2009 Oct; 136(4):991-997.
Khayat RN, Abraham WT, Patt B, Pu M, Jarjoura D. PMID: 19567491; PMCID: PMC2771043.
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PubMed Mentions:
18 Fields:
Translation:
Humans
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In-hospital testing for sleep-disordered breathing in hospitalized patients with decompensated heart failure: report of prevalence and patient characteristics. J Card Fail. 2009 Nov; 15(9):739-46.
Khayat RN, Jarjoura D, Patt B, Yamokoski T, Abraham WT. PMID: 19879459; PMCID: PMC2772830.
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PubMed Mentions:
30 Fields:
Translation:
Humans
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Hypertension in obstructive sleep apnea: risk and therapy. Expert Rev Cardiovasc Ther. 2009 Jun; 7(6):619-26.
Das AM, Khayat R. PMID: 19505277.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimals
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Obstructive sleep apnea: the new cardiovascular disease. Part I: Obstructive sleep apnea and the pathogenesis of vascular disease. Heart Fail Rev. 2009 Sep; 14(3):143-53.
Khayat R, Patt B, Hayes D. PMID: 18807180; PMCID: PMC2698951.
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PubMed Mentions:
30 Fields:
Translation:
Humans
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OSA: the new cardiovascular disease: part II: Overview of cardiovascular diseases associated with obstructive sleep apnea. Heart Fail Rev. 2009 Sep; 14(3):155-64.
Devulapally K, Pongonis R, Khayat R. PMID: 18758946; PMCID: PMC2698954.
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PubMed Mentions:
18 Fields:
Translation:
Humans
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Sleep-disordered breathing in patients with decompensated heart failure. Heart Fail Rev. 2009 Sep; 14(3):183-93.
Valdivia-Arenas MA, Powers M, Khayat RN. PMID: 18758944; PMCID: PMC2698948.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Cardiac effects of continuous and bilevel positive airway pressure for patients with heart failure and obstructive sleep apnea: a pilot study. Chest. 2008 Dec; 134(6):1162-1168.
Khayat RN, Abraham WT, Patt B, Roy M, Hua K, Jarjoura D. PMID: 18641111; PMCID: PMC2757406.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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An asian woman with eosinophilia and bilateral pulmonary infiltrates. Respiration. 2007; 74(2):224-7.
Valdivia-Arenas MA, Khayat R. PMID: 17003525.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Influence of cerebrovascular function on the hypercapnic ventilatory response in healthy humans. J Physiol. 2006 Nov 15; 577(Pt 1):319-29.
Xie A, Skatrud JB, Morgan B, Chenuel B, Khayat R, Reichmuth K, Lin J, Dempsey JA. PMID: 16931556; PMCID: PMC2000684.
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PubMed Mentions:
61 Fields:
Translation:
Humans
-
Cerebrovascular response to carbon dioxide in patients with congestive heart failure. Am J Respir Crit Care Med. 2005 Aug 01; 172(3):371-8.
Xie A, Skatrud JB, Khayat R, Dempsey JA, Morgan B, Russell D. PMID: 15901613.
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PubMed Mentions:
52 Fields:
Translation:
Humans
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Role of sensory input from the lungs in control of muscle sympathetic nerve activity during and after apnea in humans. J Appl Physiol (1985). 2004 Aug; 97(2):635-40.
Khayat RN, Przybylowski T, Meyer KC, Skatrud JB, Morgan BJ. PMID: 15075300.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Baroreflex-induced sympathetic activation does not alter cerebrovascular CO2 responsiveness in humans. J Physiol. 2003 Sep 01; 551(Pt 2):609-16.
LeMarbre G, Stauber S, Khayat RN, Puleo DS, Skatrud JB, Morgan BJ. PMID: 12844511; PMCID: PMC2343219.
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PubMed Mentions:
20 Fields:
Translation:
HumansCTClinical Trials
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Cardiorespiratory effects of added dead space in patients with heart failure and central sleep apnea. Chest. 2003 May; 123(5):1551-60.
Khayat RN, Xie A, Patel AK, Kaminski A, Skatrud JB. PMID: 12740273.
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PubMed Mentions:
26 Fields:
Translation:
Humans
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Molecular mechanism for dimerization to regulate the catalytic activity of human cytomegalovirus protease. Nat Struct Biol. 2001 Sep; 8(9):810-7.
Batra R, Khayat R, Tong L. PMID: 11524687.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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A T14C variant of Azotobacter vinelandii ferredoxin I undergoes facile [3Fe-4S]0 to [4Fe-4S]2+ conversion in vitro but not in vivo. J Biol Chem. 1998 Dec 11; 273(50):33692-701.
Gao-Sheridan HS, Kemper MA, Khayat R, Tilley GJ, Armstrong FA, Sridhar V, Prasad GS, Stout CD, Burgess BK. PMID: 9837955.
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PubMed Mentions:
5 Fields:
Translation:
Cells