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Rami Khayat

Title(s)Clinical Professor, Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. IN-HOSPITAL MANAGEMENT OF SLEEP APNEA DURING HEART FAILURE HOSPITALIZATION- A RANDOMIZED CONTROLLED TRIAL. J Card Fail. 2020 Jun 24. Khayat RN, Javaheri S, Porter K, Sow A, Holt R, Randerath W, Abraham WT, Jarjoura D. PMID: 32592897.
      View in: PubMed   Mentions:
    2. Meta-Analysis Comparing Outcomes of Therapies for Patients With Central Sleep Apnea and Heart Failure With Reduced Ejection Fraction. Am J Cardiol. 2020 Apr 24. Voigt J, Emani S, Gupta S, Germany R, Khayat R. PMID: 32430162.
      View in: PubMed   Mentions:    Fields:    
    3. Update on Apneas of Heart Failure With Reduced Ejection Fraction: Emphasis on the Physiology of Treatment: Part 2: Central Sleep Apnea. Chest. 2020 Jun; 157(6):1637-1646. Javaheri S, Brown LK, Khayat RN. PMID: 31958442.
      View in: PubMed   Mentions:    Fields:    
    4. Apneas of Heart Failure and Phenotype-Guided Treatments: Part One: OSA. Chest. 2020 Feb; 157(2):394-402. Javaheri S, Brown LK, Abraham WT, Khayat R. PMID: 31047953.
      View in: PubMed   Mentions:    Fields:    
    5. Phrenic nerve stimulation to treat patients with central sleep apnoea and heart failure. Eur J Heart Fail. 2018 12; 20(12):1746-1754. Costanzo MR, Ponikowski P, Coats A, Javaheri S, Augostini R, Goldberg LR, Holcomb R, Kao A, Khayat RN, Oldenburg O, Stellbrink C, McKane S, Abraham WT. PMID: 30303611.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    6. CON: Persistent Central Sleep Apnea/Hunter-Cheyne-Stokes Breathing, Despite Best Guideline-Based Therapy of Heart Failure With Reduced Ejection Fraction, Is Not a Compensatory Mechanism and Should Be Suppressed. J Clin Sleep Med. 2018 06 15; 14(6):915-921. Javaheri S, Brown LK, Khayat R. PMID: 29852913.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    7. Rebuttal to Naughton. J Clin Sleep Med. 2018 06 15; 14(6):923-925. Javaheri S, Brown LK, Khayat R. PMID: 29852919.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Sustained 12 Month Benefit of Phrenic Nerve Stimulation for Central Sleep Apnea. Am J Cardiol. 2018 06 01; 121(11):1400-1408. Costanzo MR, Ponikowski P, Javaheri S, Augostini R, Goldberg LR, Holcomb R, Kao A, Khayat RN, Oldenburg O, Stellbrink C, Abraham WT. PMID: 29735217.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. Sleep Apnea in Heart Failure. Curr Treat Options Cardiovasc Med. 2018 Mar 22; 20(4):33. Tsai M, Khayat R. PMID: 29568980.
      View in: PubMed   Mentions:
    10. Angiotensin Receptor Expression and Vascular Endothelial Dysfunction in Obstructive Sleep Apnea. Am J Hypertens. 2018 02 09; 31(3):355-361. Khayat RN, Varadharaj S, Porter K, Sow A, Jarjoura D, Gavrilin MA, Zweier JL. PMID: 29036393.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    11. Role of Dietary Antioxidants in the Preservation of Vascular Function and the Modulation of Health and Disease. Front Cardiovasc Med. 2017; 4:64. Varadharaj S, Kelly OJ, Khayat RN, Kumar PS, Ahmed N, Zweier JL. PMID: 29164133.
      View in: PubMed   Mentions:
    12. Adaptive servoventilation in clinical practice: beyond SERVE-HF? ERJ Open Res. 2017 Oct; 3(4). Randerath W, Schumann K, Treml M, Herkenrath S, Castrogiovanni A, Javaheri S, Khayat R. PMID: 29204433.
      View in: PubMed   Mentions:
    13. Sleep and the Heart: What's Next? Sleep Med Clin. 2017 06; 12(2):xiii-xiv. Khayat RN. PMID: 28477780.
      View in: PubMed   Mentions:    Fields:    
    14. A Practical Approach to the Identification and Management of Sleep-Disordered Breathing in Heart Failure Patients. Sleep Med Clin. 2017 Jun; 12(2):205-219. Kahwash R, Khayat RN. PMID: 28477775.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Sleep Apnea: Types, Mechanisms, and Clinical Cardiovascular Consequences. J Am Coll Cardiol. 2017 Feb 21; 69(7):841-858. Javaheri S, Barbe F, Campos-Rodriguez F, Dempsey JA, Khayat R, Javaheri S, Malhotra A, Martinez-Garcia MA, Mehra R, Pack AI, Polotsky VY, Redline S, Somers VK. PMID: 28209226.
      View in: PubMed   Mentions: 62     Fields:    Translation:Humans
    16. Snoring in the Morning Light. J Clin Sleep Med. 2016 12 15; 12(12):1581-1582. Khayat RN, Jafari B. PMID: 27855747.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Consequences of Obstructive Sleep Apnea: Cardiovascular Risk of Obstructive Sleep Apnea and Whether Continuous Positive Airway Pressure Reduces that Risk. Sleep Med Clin. 2016 Sep; 11(3):273-86. Khayat R, Pleister A. PMID: 27542874.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    18. Transvenous neurostimulation for central sleep apnoea: a randomised controlled trial. Lancet. 2016 Sep 03; 388(10048):974-82. Costanzo MR, Ponikowski P, Javaheri S, Augostini R, Goldberg L, Holcomb R, Kao A, Khayat RN, Oldenburg O, Stellbrink C, Abraham WT. PMID: 27598679.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    19. Transvenous stimulation of the phrenic nerve for the treatment of central sleep apnoea: 12 months' experience with the remedeĀ® System. Eur J Heart Fail. 2016 11; 18(11):1386-1393. Jagielski D, Ponikowski P, Augostini R, Kolodziej A, Khayat R, Abraham WT. PMID: 27373452.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    20. Current treatment approaches and trials in central sleep apnea. Int J Cardiol. 2016 Mar; 206 Suppl:S22-7. Khayat RN, Abraham WT. PMID: 26961738.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    21. SERVE-HF: More Questions Than Answers. Chest. 2016 Apr; 149(4):900-4. Javaheri S, Brown LK, Randerath W, Khayat R. PMID: 26836904.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    22. Missing links. Sleep Med. 2015 Dec; 16(12):1495-6. Randerath W, Khayat R, Arzt M, Javaheri S. PMID: 26611946.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Are Mindfulness and Self-Compassion Associated with Sleep and Resilience in Health Professionals? J Altern Complement Med. 2015 Aug; 21(8):496-503. Kemper KJ, Mo X, Khayat R. PMID: 26218885.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    24. Phrenic nerve stimulation for the treatment of central sleep apnea. JACC Heart Fail. 2015 May; 3(5):360-369. Abraham WT, Jagielski D, Oldenburg O, Augostini R, Krueger S, Kolodziej A, Gutleben KJ, Khayat R, Merliss A, Harsch MR, Holcomb RG, Javaheri S, Ponikowski P. PMID: 25770408.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCTClinical Trials
    25. Sleep disordered breathing and post-discharge mortality in patients with acute heart failure. Eur Heart J. 2015 Jun 14; 36(23):1463-9. Khayat R, Jarjoura D, Porter K, Sow A, Wannemacher J, Dohar R, Pleister A, Abraham WT. PMID: 25636743.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    26. Mechanisms and clinical consequences of untreated central sleep apnea in heart failure. J Am Coll Cardiol. 2015 Jan 06; 65(1):72-84. Costanzo MR, Khayat R, Ponikowski P, Augostini R, Stellbrink C, Mianulli M, Abraham WT. PMID: 25572513.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    27. Endothelial nitric oxide synthase uncoupling: a novel pathway in OSA induced vascular endothelial dysfunction. Respir Physiol Neurobiol. 2015 Feb 01; 207:40-7. Varadharaj S, Porter K, Pleister A, Wannemacher J, Sow A, Jarjoura D, Zweier JL, Khayat RN. PMID: 25534145.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    28. Obstructive sleep apnea and atrial fibrillation: understanding the connection. Expert Rev Cardiovasc Ther. 2014 May; 12(5):613-21. Oza N, Baveja S, Khayat R, Houmsse M. PMID: 24731146.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    29. Sleep-disordered breathing in heart failure: identifying and treating an important but often unrecognized comorbidity in heart failure patients. J Card Fail. 2013 Jun; 19(6):431-44. Khayat R, Small R, Rathman L, Krueger S, Gocke B, Clark L, Yamokoski L, Abraham WT. PMID: 23743494.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    30. Issues applying a math model to estimate continuous positive airway pressure response in Cheyne-Stokes respiration. Am J Respir Crit Care Med. 2013 Mar 01; 187(5):553. Campbell L, Best J, Khayat R, Splaingard M. PMID: 23457367.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    31. Central sleep apnea is a predictor of cardiac readmission in hospitalized patients with systolic heart failure. J Card Fail. 2012 Jul; 18(7):534-40. Khayat R, Abraham W, Patt B, Brinkman V, Wannemacher J, Porter K, Jarjoura D. PMID: 22748486.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    32. The performance of two automatic servo-ventilation devices in the treatment of central sleep apnea. Sleep. 2011 Dec 01; 34(12):1693-8. Javaheri S, Goetting MG, Khayat R, Wylie PE, Goodwin JL, Parthasarathy S. PMID: 22131607.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    33. Transvenous phrenic nerve stimulation for the treatment of central sleep apnoea in heart failure. Eur Heart J. 2012 Apr; 33(7):889-94. Ponikowski P, Javaheri S, Michalkiewicz D, Bart BA, Czarnecka D, Jastrzebski M, Kusiak A, Augostini R, Jagielski D, Witkowski T, Khayat RN, Oldenburg O, Gutleben KJ, Bitter T, Karim R, Iber C, Hasan A, Hibler K, Germany R, Abraham WT. PMID: 21856678.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    34. Recognition and management of sleep-disordered breathing in chronic heart failure. Curr Heart Fail Rep. 2011 Mar; 8(1):72-9. Kahwash R, Kikta D, Khayat R. PMID: 21086079.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    35. Prevalence of obstructive sleep apnea in patients with chronic wounds. J Clin Sleep Med. 2010 Dec 15; 6(6):541-4. Patt BT, Jarjoura D, Lambert L, Roy S, Gordillo G, Schlanger R, Sen CK, Khayat RN. PMID: 21206743.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    36. Endothelial dysfunction in the microcirculation of patients with obstructive sleep apnea. Am J Respir Crit Care Med. 2010 Dec 15; 182(12):1540-5. Patt BT, Jarjoura D, Haddad DN, Sen CK, Roy S, Flavahan NA, Khayat RN. PMID: 20656942.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    37. In-hospital treatment of obstructive sleep apnea during decompensation of heart failure. Chest. 2009 Oct; 136(4):991-997. Khayat RN, Abraham WT, Patt B, Pu M, Jarjoura D. PMID: 19567491.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    38. In-hospital testing for sleep-disordered breathing in hospitalized patients with decompensated heart failure: report of prevalence and patient characteristics. J Card Fail. 2009 Nov; 15(9):739-46. Khayat RN, Jarjoura D, Patt B, Yamokoski T, Abraham WT. PMID: 19879459.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    39. Hypertension in obstructive sleep apnea: risk and therapy. Expert Rev Cardiovasc Ther. 2009 Jun; 7(6):619-26. Das AM, Khayat R. PMID: 19505277.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    40. Obstructive sleep apnea: the new cardiovascular disease. Part I: Obstructive sleep apnea and the pathogenesis of vascular disease. Heart Fail Rev. 2009 Sep; 14(3):143-53. Khayat R, Patt B, Hayes D. PMID: 18807180.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    41. OSA: the new cardiovascular disease: part II: Overview of cardiovascular diseases associated with obstructive sleep apnea. Heart Fail Rev. 2009 Sep; 14(3):155-64. Devulapally K, Pongonis R, Khayat R. PMID: 18758946.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    42. Sleep-disordered breathing in patients with decompensated heart failure. Heart Fail Rev. 2009 Sep; 14(3):183-93. Valdivia-Arenas MA, Powers M, Khayat RN. PMID: 18758944.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    43. Cardiac effects of continuous and bilevel positive airway pressure for patients with heart failure and obstructive sleep apnea: a pilot study. Chest. 2008 Dec; 134(6):1162-1168. Khayat RN, Abraham WT, Patt B, Roy M, Hua K, Jarjoura D. PMID: 18641111.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    44. An asian woman with eosinophilia and bilateral pulmonary infiltrates. Respiration. 2007; 74(2):224-7. Valdivia-Arenas MA, Khayat R. PMID: 17003525.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    45. Influence of cerebrovascular function on the hypercapnic ventilatory response in healthy humans. J Physiol. 2006 Nov 15; 577(Pt 1):319-29. Xie A, Skatrud JB, Morgan B, Chenuel B, Khayat R, Reichmuth K, Lin J, Dempsey JA. PMID: 16931556.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    46. Cerebrovascular response to carbon dioxide in patients with congestive heart failure. Am J Respir Crit Care Med. 2005 Aug 01; 172(3):371-8. Xie A, Skatrud JB, Khayat R, Dempsey JA, Morgan B, Russell D. PMID: 15901613.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    47. Role of sensory input from the lungs in control of muscle sympathetic nerve activity during and after apnea in humans. J Appl Physiol (1985). 2004 Aug; 97(2):635-40. Khayat RN, Przybylowski T, Meyer KC, Skatrud JB, Morgan BJ. PMID: 15075300.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    48. Baroreflex-induced sympathetic activation does not alter cerebrovascular CO2 responsiveness in humans. J Physiol. 2003 Sep 01; 551(Pt 2):609-16. LeMarbre G, Stauber S, Khayat RN, Puleo DS, Skatrud JB, Morgan BJ. PMID: 12844511.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCTClinical Trials
    49. Cardiorespiratory effects of added dead space in patients with heart failure and central sleep apnea. Chest. 2003 May; 123(5):1551-60. Khayat RN, Xie A, Patel AK, Kaminski A, Skatrud JB. PMID: 12740273.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    50. Molecular mechanism for dimerization to regulate the catalytic activity of human cytomegalovirus protease. Nat Struct Biol. 2001 Sep; 8(9):810-7. Batra R, Khayat R, Tong L. PMID: 11524687.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    51. A T14C variant of Azotobacter vinelandii ferredoxin I undergoes facile [3Fe-4S]0 to [4Fe-4S]2+ conversion in vitro but not in vivo. J Biol Chem. 1998 Dec 11; 273(50):33692-701. Gao-Sheridan HS, Kemper MA, Khayat R, Tilley GJ, Armstrong FA, Sridhar V, Prasad GS, Stout CD, Burgess BK. PMID: 9837955.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
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