Ralph A Bradshaw

Title(s)Professor Emeritus, Physiology and Biophysics
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 904-8365
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    ASBMB FALL SYMPOSIUM REGULATION OF BONE FORMATION
    NIH R13AR045869Sep 25, 1998 - Aug 31, 1999
    Role: Principal Investigator
    HIGH SENSITIVITY PROTEIN ISOLATION/ANALYTICAL SYSTEM
    NIH S10RR005053May 26, 1989 - May 25, 1990
    Role: Principal Investigator
    PROTEIN/PEPTIDE SEQUENCING AND SYNTHESIS
    NIH S10RR003443Apr 1, 1987 - Mar 31, 1988
    Role: Principal Investigator
    PROTEIN ANALYSIS EQUIPMENT
    NIH S10RR002397Feb 1, 1985 - Jan 31, 1986
    Role: Principal Investigator
    COTRANSLATIONAL PROCESSING AND PROTEIN TURNOVER
    NIH R01DK032465Dec 1, 1982 - Jun 30, 2003
    Role: Principal Investigator
    STRUCTURE OF DEHYDROGENASES AND OTHER PROTEINS
    NIH R01AM032465Dec 1, 1982 - Nov 30, 1985
    Role: Principal Investigator
    STRUCTURE AND FUNCTION OF NERVE GROWTH FACTOR
    NIH R01AG009735Sep 1, 1982 - Aug 31, 2001
    Role: Principal Investigator
    STRUCTURE AND FUNCTION OF NERVE GROWTH FACTOR
    NIH R01NS019964Sep 1, 1982 - Dec 31, 1989
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Regenerative responses of rabbit corneal endothelial cells to stimulation by fibroblast growth factor 1 (FGF1) derivatives, TTHX1001 and TTHX1114. Growth Factors. 2021 Feb-Jul; 39(1-6):14-27. Weant J, Eveleth DD, Subramaniam A, Jenkins-Eveleth J, Blaber M, Li L, Ornitz DM, Alimardanov A, Broadt T, Dong H, Vyas V, Yang X, Bradshaw RA. PMID: 34879776.
      View in: PubMed   Mentions:
    2. Characterization of a Novel Caveolin Modulator That Reduces Vascular Permeability and Ocular Inflammation. Transl Vis Sci Technol. 2021 05 03; 10(6):21. Bernatchez PN, Tao B, Bradshaw RA, Eveleth D, Sessa WC. PMID: 34111267; PMCID: PMC8132009.
      View in: PubMed   Mentions:
    3. Starting over and thinking long term…. FASEB Bioadv. 2021 Apr; 3(4):203-204. Bradshaw RA, Stahl PD. PMID: 33842846; PMCID: PMC8019257.
      View in: PubMed   Mentions:
    4. Managing medical curricula during the pandemic-A special collection. FASEB Bioadv. 2021 Feb; 3(2):108-109. Aagaard EM, Bradshaw RA, Stahl PD. PMID: 33615155; PMCID: PMC7876700.
      View in: PubMed   Mentions:
    5. Broadening the Scope (Part II)…. FASEB Bioadv. 2020 Sep; 2(9):525. Bradshaw RA, Stahl PD. PMID: 32923986; PMCID: PMC7475299.
      View in: PubMed   Mentions:
    6. Proliferation of Human Corneal Endothelia in Organ Culture Stimulated by Wounding and the Engineered Human Fibroblast Growth Factor 1 Derivative TTHX1114. J Ocul Pharmacol Ther. 2020 11; 36(9):686-696. Eveleth D, Pizzuto S, Weant J, Jenkins-Eveleth J, Bradshaw RA. PMID: 32735473; PMCID: PMC7703086.
      View in: PubMed   Mentions:
    7. A brief history of FASEB and its programs and activities. FASEB Bioadv. 2020 Jun; 2(6):331-338. Garrison HH, Bond JS, Bradshaw RA. PMID: 32617519; PMCID: PMC7325587.
      View in: PubMed   Mentions:
    8. On pandemics, pandemonium, and possibilities…. FASEB Bioadv. 2020 Jun; 2(6):329-330. Bradshaw RA, Stahl PD. PMID: 32617518; PMCID: PMC7325586.
      View in: PubMed   Mentions:
    9. Broadening the Scope…. FASEB Bioadv. 2020 May; 2(5):285. Bradshaw RA. PMID: 32395700; PMCID: PMC7211038.
      View in: PubMed   Mentions:
    10. Cancer Proteomics and the Elusive Diagnostic Biomarkers. Proteomics. 2019 11; 19(21-22):e1800445. Bradshaw RA, Hondermarck H, Rodriguez H. PMID: 31172665.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    11. FASEB BioAdvances-Introductory editorial. FASEB Bioadv. 2019 Jun; 1(6):349. Bradshaw RA. PMID: 32123837; PMCID: PMC6996364.
      View in: PubMed   Mentions:
    12. An Engineered Human Fibroblast Growth Factor-1 Derivative, TTHX1114, Ameliorates Short-term Corneal Nitrogen Mustard Injury in Rabbit Organ Cultures. Invest Ophthalmol Vis Sci. 2018 09 04; 59(11):4720-4730. Eveleth DD, Eveleth JJ, Subramaniam A, Hahn R, Zhou P, Gordon MK, Bradshaw RA. PMID: 30267094; PMCID: PMC6155473.
      View in: PubMed   Mentions:
    13. Nerve Growth Factor and Related Substances: A Brief History and an Introduction to the International NGF Meeting Series. Int J Mol Sci. 2017 May 26; 18(6). Bradshaw RA, Mobley W, Rush RA. PMID: 28587118; PMCID: PMC5485967.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    14. New Guidelines for Publication of Manuscripts Describing Development and Application of Targeted Mass Spectrometry Measurements of Peptides and Proteins. Mol Cell Proteomics. 2017 03; 16(3):327-328. Abbatiello S, Ackermann BL, Borchers C, Bradshaw RA, Carr SA, Chalkley R, Choi M, Deutsch E, Domon B, Hoofnagle AN, Keshishian H, Kuhn E, Liebler DC, MacCoss M, MacLean B, Mani DR, Neubert H, Smith D, Vitek O, Zimmerman L. PMID: 28183812; PMCID: PMC5340997.
      View in: PubMed   Mentions: 21     Fields:    
    15. Proteomics in India: A Report on a Brainstorming Meeting at Hyderabad, India. Mol Cell Proteomics. 2016 07; 15(7):2229-35. Chatterjee B, Makarov A, Clemmer DE, Steen H, Steen J, Saffell-Clemmer W, Moghekar AR, Mohan Rao C, Bradshaw RA, Thakur SS. PMID: 27114450; PMCID: PMC4937500.
      View in: PubMed   Mentions:
    16. On Credibility, Clarity, and Compliance. Mol Cell Proteomics. 2015 Jul; 14(7):1731-3. Burlingame A, Carr SA, Bradshaw RA, Chalkley RJ. PMID: 26041845; PMCID: PMC4587320.
      View in: PubMed   Mentions: 8     Fields:    
    17. Proteotranscriptomic Profiling of 231-BR Breast Cancer Cells: Identification of Potential Biomarkers and Therapeutic Targets for Brain Metastasis. Mol Cell Proteomics. 2015 Sep; 14(9):2316-30. Dun MD, Chalkley RJ, Faulkner S, Keene S, Avery-Kiejda KA, Scott RJ, Falkenby LG, Cairns MJ, Larsen MR, Bradshaw RA, Hondermarck H. PMID: 26041846; PMCID: PMC4563718.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    18. Nerve fibers infiltrate the tumor microenvironment and are associated with nerve growth factor production and lymph node invasion in breast cancer. Mol Oncol. 2015 Oct; 9(8):1626-35. Pundavela J, Roselli S, Faulkner S, Attia J, Scott RJ, Thorne RF, Forbes JF, Bradshaw RA, Walker MM, Jobling P, Hondermarck H. PMID: 26009480; PMCID: PMC5528785.
      View in: PubMed   Mentions:
    19. Minireviews revisited. Mol Cell Proteomics. 2015 Mar; 14(3):455. Bradshaw RA, Burlingame AL. PMID: 25657218; PMCID: PMC4349968.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    20. NGF and ProNGF: Regulation of neuronal and neoplastic responses through receptor signaling. Adv Biol Regul. 2015 May; 58:16-27. Bradshaw RA, Pundavela J, Biarc J, Chalkley RJ, Burlingame AL, Hondermarck H. PMID: 25491371; PMCID: PMC4426037.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    21. ProNGF correlates with Gleason score and is a potential driver of nerve infiltration in prostate cancer. Am J Pathol. 2014 Dec; 184(12):3156-62. Pundavela J, Demont Y, Jobling P, Lincz LF, Roselli S, Thorne RF, Bond D, Bradshaw RA, Walker MM, Hondermarck H. PMID: 25285721.
      View in: PubMed   Mentions:
    22. Dick Hanson and the launch of MCP: a personal reflection. Mol Cell Proteomics. 2014 May; 13(5):1150-2. Bradshaw RA. PMID: 24710324; PMCID: PMC4014275.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Targeted peptide measurements in biology and medicine: best practices for mass spectrometry-based assay development using a fit-for-purpose approach. Mol Cell Proteomics. 2014 Mar; 13(3):907-17. Carr SA, Abbatiello SE, Ackermann BL, Borchers C, Domon B, Deutsch EW, Grant RP, Hoofnagle AN, Hüttenhain R, Koomen JM, Liebler DC, Liu T, MacLean B, Mani DR, Mansfield E, Neubert H, Paulovich AG, Reiter L, Vitek O, Aebersold R, Anderson L, Bethem R, Blonder J, Boja E, Botelho J, Boyne M, Bradshaw RA, Burlingame AL, Chan D, Keshishian H, Kuhn E, Kinsinger C, Lee JS, Lee SW, Moritz R, Oses-Prieto J, Rifai N, Ritchie J, Rodriguez H, Srinivas PR, Townsend RR, Van Eyk J, Whiteley G, Wiita A, Weintraub S. PMID: 24443746; PMCID: PMC3945918.
      View in: PubMed   Mentions: 244     Fields:    Translation:HumansAnimals
    24. Western blots versus selected reaction monitoring assays: time to turn the tables? Mol Cell Proteomics. 2013 Sep; 12(9):2381-2. Aebersold R, Burlingame AL, Bradshaw RA. PMID: 23756428; PMCID: PMC3769317.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansCells
    25. Dissecting the roles of tyrosines 490 and 785 of TrkA protein in the induction of downstream protein phosphorylation using chimeric receptors. J Biol Chem. 2013 Jun 07; 288(23):16606-16618. Biarc J, Chalkley RJ, Burlingame AL, Bradshaw RA. PMID: 23589303; PMCID: PMC3675596.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    26. Rita Levi-Montalcini (1909-2012). Nature. 2013 Jan 17; 493(7432):306. Bradshaw RA. PMID: 23325208.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    27. N-terminal protein processing: a comparative proteogenomic analysis. Mol Cell Proteomics. 2013 Jan; 12(1):14-28. Bonissone S, Gupta N, Romine M, Bradshaw RA, Pevzner PA. PMID: 23001859; PMCID: PMC3536895.
      View in: PubMed   Mentions: 43     Fields:    Translation:Cells
    28. Recommendations for mass spectrometry data quality metrics for open access data (corollary to the Amsterdam principles). Proteomics. 2012 Jan; 12(1):11-20. Kinsinger CR, Apffel J, Baker M, Bian X, Borchers CH, Bradshaw R, Brusniak MY, Chan DW, Deutsch EW, Domon B, Gorman J, Grimm R, Hancock W, Hermjakob H, Horn D, Hunter C, Kolar P, Kraus HJ, Langen H, Linding R, Moritz RL, Omenn GS, Orlando R, Pandey A, Ping P, Rahbar A, Rivers R, Seymour SL, Simpson RJ, Slotta D, Smith RD, Stein SE, Tabb DL, Tagle D, Yates JR, Rodriguez H. PMID: 22069307.
      View in: PubMed   Mentions: 8     Fields:    
    29. Recommendations for mass spectrometry data quality metrics for open access data (corollary to the Amsterdam Principles). J Proteome Res. 2012 Feb 03; 11(2):1412-9. Kinsinger CR, Apffel J, Baker M, Bian X, Borchers CH, Bradshaw R, Brusniak MY, Chan DW, Deutsch EW, Domon B, Gorman J, Grimm R, Hancock W, Hermjakob H, Horn D, Hunter C, Kolar P, Kraus HJ, Langen H, Linding R, Moritz RL, Omenn GS, Orlando R, Pandey A, Ping P, Rahbar A, Rivers R, Seymour SL, Simpson RJ, Slotta D, Smith RD, Stein SE, Tabb DL, Tagle D, Yates JR, Rodriguez H. PMID: 22053864; PMCID: PMC3272102.
      View in: PubMed   Mentions: 11     Fields:    
    30. Recommendations for mass spectrometry data quality metrics for open access data (corollary to the Amsterdam principles). Proteomics Clin Appl. 2011 Dec; 5(11-12):580-9. Kinsinger CR, Apffel J, Baker M, Bian X, Borchers CH, Bradshaw R, Brusniak MY, Chan DW, Deutsch EW, Domon B, Gorman J, Grimm R, Hancock W, Hermjakob H, Horn D, Hunter C, Kolar P, Kraus HJ, Langen H, Linding R, Moritz RL, Omenn GS, Orlando R, Pandey A, Ping P, Rahbar A, Rivers R, Seymour SL, Simpson RJ, Slotta D, Smith RD, Stein SE, Tabb DL, Tagle D, Yates JR, Rodriguez H. PMID: 22213554.
      View in: PubMed   Mentions: 3     Fields:    
    31. Pro-nerve growth factor induces autocrine stimulation of breast cancer cell invasion through tropomyosin-related kinase A (TrkA) and sortilin protein. J Biol Chem. 2012 Jan 13; 287(3):1923-31. Demont Y, Corbet C, Page A, Ataman-Önal Y, Choquet-Kastylevsky G, Fliniaux I, Le Bourhis X, Toillon RA, Bradshaw RA, Hondermarck H. PMID: 22128158; PMCID: PMC3265873.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    32. Recommendations for mass spectrometry data quality metrics for open access data (corollary to the Amsterdam Principles). Mol Cell Proteomics. 2011 Dec; 10(12):O111.015446. Kinsinger CR, Apffel J, Baker M, Bian X, Borchers CH, Bradshaw R, Brusniak MY, Chan DW, Deutsch EW, Domon B, Gorman J, Grimm R, Hancock W, Hermjakob H, Horn D, Hunter C, Kolar P, Kraus HJ, Langen H, Linding R, Moritz RL, Omenn GS, Orlando R, Pandey A, Ping P, Rahbar A, Rivers R, Seymour SL, Simpson RJ, Slotta D, Smith RD, Stein SE, Tabb DL, Tagle D, Yates JR, Rodriguez H. PMID: 22052993; PMCID: PMC3237091.
      View in: PubMed   Mentions: 10     Fields:    
    33. The induction of serine/threonine protein phosphorylations by a PDGFR/TrkA chimera in stably transfected PC12 cells. Mol Cell Proteomics. 2012 May; 11(5):15-30. Biarc J, Chalkley RJ, Burlingame AL, Bradshaw RA. PMID: 22027198; PMCID: PMC3418849.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    34. Time to articulate a vision for the future of plant proteomics - A global perspective: An initiative for establishing the International Plant Proteomics Organization (INPPO). Proteomics. 2011 May; 11(9):1559-68. Agrawal GK, Job D, Zivy M, Agrawal VP, Bradshaw RA, Dunn MJ, Haynes PA, van Wijk KJ, Kikuchi S, Renaut J, Weckwerth W, Rakwal R. PMID: 21433283.
      View in: PubMed   Mentions:
    35. Receptor tyrosine kinase signaling--a proteomic perspective. Adv Enzyme Regul. 2011; 51(1):293-305. Biarc J, Chalkley RJ, Burlingame AL, Bradshaw RA. PMID: 21056590; PMCID: PMC3079071.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    36. Technological innovation revisited. Mol Cell Proteomics. 2010 Nov; 9(11):2335-6. Bradshaw RA, Burlingame AL. PMID: 20943599; PMCID: PMC2984236.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    37. Protein PTMs: post-translational modifications or pesky trouble makers? J Mass Spectrom. 2010 Oct; 45(10):1095-7. Bradshaw RA, Medzihradszky KF, Chalkley RJ. PMID: 20635432; PMCID: PMC3133960.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    38. What has proteomics accomplished? Mol Cell Proteomics. 2007 Oct; 6(10):1824-6. Bergeron JJ, Bradshaw RA. PMID: 17913850.
      View in: PubMed   Mentions:
    39. How I became a biochemist. IUBMB Life. 2006 Aug; 58(8):495-8. Bradshaw RA. PMID: 16916789.
      View in: PubMed   Mentions:    Fields:    
    40. Reporting protein identification data: the next generation of guidelines. Mol Cell Proteomics. 2006 May; 5(5):787-8. Bradshaw RA, Burlingame AL, Carr S, Aebersold R. PMID: 16670253.
      View in: PubMed   Mentions: 96     Fields:    
    41. Protein identification: the good, the bad, and the ugly. Mol Cell Proteomics. 2005 Sep; 4(9):1221-2. Bradshaw RA, Burlingame AL, Carr S, Aebersold R. PMID: 16160099.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    42. Revised draft guidelines for proteomic data publication. Mol Cell Proteomics. 2005 Sep; 4(9):1223-5. Bradshaw RA. PMID: 16160100.
      View in: PubMed   Mentions:
    43. Characterization of symmetric complexes of nerve growth factor and the ectodomain of the pan-neurotrophin receptor, p75NTR. J Biol Chem. 2005 Sep 30; 280(39):33453-60. Aurikko JP, Ruotolo BT, Grossmann JG, Moncrieffe MC, Stephens E, Leppänen VM, Robinson CV, Saarma M, Bradshaw RA, Blundell TL. PMID: 16009712; PMCID: PMC1352310.
      View in: PubMed   Mentions:
    44. Sustained ERK1/2 but not STAT1 or 3 activation is required for thanatophoric dysplasia phenotypes in PC12 cells. Hum Mol Genet. 2005 Jun 01; 14(11):1529-38. Nowroozi N, Raffioni S, Wang T, Apostol BL, Bradshaw RA, Thompson LM. PMID: 15843401.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    45. From proteins to proteomics. IUBMB Life. 2005 Apr-May; 57(4-5):267-72. Bradshaw RA, Burlingame AL. PMID: 16036609.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    46. Nerve growth factor expression response to induction agent booster dosing in transfected human embryonic kidney cells. Plast Reconstr Surg. 2005 Feb; 115(2):506-14. McConnell MP, Dhar S, Nguyen T, Naran S, Calvert JW, Sundine MJ, Bradshaw RA, Evans GR. PMID: 15692357.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    47. In vivo induction and delivery of nerve growth factor, using HEK-293 cells. Tissue Eng. 2004 Sep-Oct; 10(9-10):1492-501. McConnell MP, Dhar S, Naran S, Nguyen T, Bradshaw RA, Evans GR. PMID: 15588408.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    48. A review of the therapeutic uses of thrombin. Thromb Haemost. 2004 May; 91(5):851-60. Lundblad RL, Bradshaw RA, Gabriel D, Ortel TL, Lawson J, Mann KG. PMID: 15116244.
      View in: PubMed   Mentions:
    49. Human embryonic kidney cells (HEK-293 cells): characterization and dose-response relationship for modulated release of nerve growth factor for nerve regeneration. Plast Reconstr Surg. 2004 Feb; 113(2):605-10. Jimenez JC, Tyson DR, Dhar S, Nguyen T, Hamai Y, Bradshaw RA, Evans GR. PMID: 14758223.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    50. Individual and combined effects of TrkA and p75NTR nerve growth factor receptors. A role for the high affinity receptor site. J Biol Chem. 2003 Jul 04; 278(27):24808-17. Lad SP, Peterson DA, Bradshaw RA, Neet KE. PMID: 12702729.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    51. PC12 cell activation by epidermal growth factor receptor: role of autophosphorylation sites. Int J Dev Neurosci. 2003 Apr; 21(2):63-74. Tyson DR, Larkin S, Hamai Y, Bradshaw RA. PMID: 12615082.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    52. Proteomics - boom or bust? Mol Cell Proteomics. 2002 Mar; 1(3):177-8. Bradshaw RA. PMID: 12096116.
      View in: PubMed   Mentions:
    53. Methionine aminopeptidases and angiogenesis. Essays Biochem. 2002; 38:65-78. Bradshaw RA, Yi E. PMID: 12463162.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
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