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Petra E E B Wilder-Smith

Title(s)Professor In Residence, Beckman Laser Institute
Phone(949) 824-7632
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    Collapse Research Activities and Funding
    Low-cost, noninvasive method to assess pulpal vitality
    NIH/NIDCR R01DE022831Mar 7, 2013 - Feb 29, 2016
    Role: Co-Principal Investigator
    A Low-Cost Simple Oral Cancer Screening Device for Low-Resource Settings
    NIH/NIBIB R03EB014852Jun 1, 2012 - May 31, 2015
    Role: Principal Investigator
    FLUORESCENCE BASED DETECTION AND DIAGNOSIS OF MALIGNANCY
    NIH/NCI R21CA087527May 1, 2000 - Apr 30, 2003
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lin K, Takesh T, Lee JH, Duong DN, Nguyen AH, Cheung RK, Nguyen BL, Wilder-Smith P, Cobb CM. Effects of a Dental Gel Over 6 Months on Periodontal Health in Subjects with Stage II and III (Mild and Moderate) Periodontitis. J Dent Oral Sci. 2019 Dec; 1(3). PMID: 31893264.
      View in: PubMed
    2. Uthoff RD, Song B, Sunny S, Patrick S, Suresh A, Kolur T, Gurushanth K, Wooten K, Gupta V, Platek ME, Singh AK, Wilder-Smith P, Kuriakose MA, Birur P, Liang R. Small form factor, flexible, dual-modality handheld probe for smartphone-based, point-of-care oral and oropharyngeal cancer screening. J Biomed Opt. 2019 10; 24(10):1-8. PMID: 31642247.
      View in: PubMed
    3. Sunny SP, Agarwal S, James BL, Heidari E, Muralidharan A, Yadav V, Pillai V, Shetty V, Chen Z, Hedne N, Wilder-Smith P, Suresh A, Kuriakose MA. Intra-operative point-of-procedure delineation of oral cancer margins using optical coherence tomography. Oral Oncol. 2019 05; 92:12-19. PMID: 31010617.
      View in: PubMed
    4. Uthoff RD, Song B, Sunny S, Patrick S, Suresh A, Kolur T, Keerthi G, Spires O, Anbarani A, Wilder-Smith P, Kuriakose MA, Birur P, Liang R. Point-of-care, smartphone-based, dual-modality, dual-view, oral cancer screening device with neural network classification for low-resource communities. PLoS One. 2018; 13(12):e0207493. PMID: 30517120.
      View in: PubMed
    5. Song B, Sunny S, Uthoff RD, Patrick S, Suresh A, Kolur T, Keerthi G, Anbarani A, Wilder-Smith P, Kuriakose MA, Birur P, Rodriguez JJ, Liang R. Automatic classification of dual-modalilty, smartphone-based oral dysplasia and malignancy images using deep learning. Biomed Opt Express. 2018 Nov 01; 9(11):5318-5329. PMID: 30460130.
      View in: PubMed
    6. Takesh T, Ho J, Firmalino MV, Islip D, Anbarani A, Wilder-Smith P. Effects of a Novel Formulation on Oral Biofilm, pH Buffering, and Gingival Health in Patients with Dry Mouth. Int J Dent. 2018; 2018:2748274. PMID: 30356392.
      View in: PubMed
    7. Birur NP, Patrick S, Bajaj S, Raghavan S, Suresh A, Sunny SP, Chigurupati R, Wilder-Smith P, Gurushanth K, Gurudath S, Rao P, Kuriakose MA. A Novel Mobile Health Approach to Early Diagnosis of Oral Cancer. J Contemp Dent Pract. 2018 Sep 01; 19(9):1122-1128. PMID: 30287715.
      View in: PubMed
    8. Anbarani AG, Wink C, Ho J, Lam T, Sahni K, Forghany A, Ngo W, Vu T, Ajdaharian J, Takesh T, Wilder-Smith P. Dental Plaque Removal and Re-Accumulation: A Clinical Randomized Pilot Study Evaluating a Gel Dentifrice Containing 2.6% Edathamil. J Clin Dent. 2018 Jun; 29(2):40-44. PMID: 30211989.
      View in: PubMed
    9. Kim CS, Ingato D, Wilder-Smith P, Chen Z, Kwon YJ. Stimuli-disassembling gold nanoclusters for diagnosis of early stage oral cancer by optical coherence tomography. Nano Converg. 2018; 5(1):3. PMID: 29399435.
      View in: PubMed
    10. Anbarani AG, Ho J, Vu TH, Forghany A, Lam T, Khashai E, Sahni K, Takesh T, Wilder-Smith P. A Double-Blinded, Randomized Study Evaluating the In Vivo Effects of a Novel Dental Gel on Enamel Surface Microstructure and Microhardness. J Clin Dent. 2017 Sep; 28(3):49-55. PMID: 29211951.
      View in: PubMed
    11. Takesh T, Sargsyan A, Lee M, Anbarani A, Ho J, Wilder-Smith P. Evaluating the Whitening and Microstructural Effects of a Novel Whitening Strip on Porcelain and Composite Dental Materials. Dentistry (Sunnyvale). 2017 Aug; 7(8). PMID: 29226023.
      View in: PubMed
    12. Ajdaharian J, Takesh T, Anbarani A, Ho J, Wilder-Smith P. Effects of a Novel Mouthwash on Dental Remineralization. Dentistry (Sunnyvale). 2017; 7(5). PMID: 29629237.
      View in: PubMed
    13. Takesh T, Sargsyan A, Anbarani A, Ho J, Wilder-Smith P. Effects of a Novel Whitening Formulation on Dental Enamel. Dentistry (Sunnyvale). 2017 Apr; 7(4). PMID: 28706755.
      View in: PubMed
    14. Ho J, Firmalino MV, Anbarani AG, Takesh T, Epstein J, Wilder-Smith P. Effects of A Novel Disc Formulation on Dry Mouth Symptoms and Enamel Remineralization in Patients With Hyposalivation: An In Vivo Study. Dentistry (Sunnyvale). 2017 Feb; 7(2). PMID: 28713645.
      View in: PubMed
    15. Arany PR, Wilder-Smith P. Special issue on lasers in dentistry. Lasers Surg Med. 2016 12; 48(10):912-914. PMID: 27868208.
      View in: PubMed
    16. Lam T, Ho J, Anbarani AG, Liaw LH, Takesh T, Wilder-Smith P. Effects of a Novel Dental Gel on Enamel Surface Recovery from Acid Challenge. Dentistry (Sunnyvale). 2016 Oct; 6(10). PMID: 28344856.
      View in: PubMed
    17. Nayudu A, Lam T, Ho J, Forghany A, Vu T, Ngo W, Ajdaharian J, Wilder-Smith P. Plaque Removal and Gingival Health after Use of a Novel Dental Gel: A Clinical Study. Dentistry (Sunnyvale). 2016 Oct; 6(10). PMID: 28286702.
      View in: PubMed
    18. Regan C, White SM, Yang BY, Takesh T, Ho J, Wink C, Wilder-Smith P, Choi B. Design and evaluation of a miniature laser speckle imaging device to assess gingival health. J Biomed Opt. 2016 10 01; 21(10):104002. PMID: 27787545.
      View in: PubMed
    19. Sahni K, Khashai F, Forghany A, Krasieva T, Wilder-Smith P. Exploring Mechanisms of Biofilm Removal. Dentistry (Sunnyvale). 2016 Apr; 6(4). PMID: 27413588.
      View in: PubMed
    20. Mansour S, Ajdaharian J, Nabelsi T, Chan G, Wilder-Smith P. Comparison of caries diagnostic modalities: A clinical study in 40 subjects. Lasers Surg Med. 2016 12; 48(10):924-928. PMID: 26997616.
      View in: PubMed
    21. Holtzman JS, Kohanchi D, Biren-Fetz J, Fontana M, Ramchandani M, Osann K, Hallajian L, Mansour S, Nabelsi T, Chung NE, Wilder-Smith P. Detection and proportion of very early dental caries in independent living older adults. Lasers Surg Med. 2015 Nov; 47(9):683-8. PMID: 26414887.
      View in: PubMed
    22. Regan C, Yang BY, Mayzel KC, Ramirez-San-Juan JC, Wilder-Smith P, Choi B. Fiber-based laser speckle imaging for the detection of pulsatile flow. Lasers Surg Med. 2015 Aug; 47(6):520-5. PMID: 26202900.
      View in: PubMed
    23. Ajdaharian J, Dadkhah M, Sabokpey S, Biren-Fetz J, Chung NE, Wink C, Wilder-Smith P. Multimodality imaging of the effects of a novel dentifrice on oral biofilm. Lasers Surg Med. 2014 Sep; 46(7):546-52. PMID: 24916419.
      View in: PubMed
    24. Dadkhah M, Chung NE, Ajdaharian J, Wink C, Klokkevold P, Wilder-Smith P. Effects of a Novel Dental Gel on Plaque and Gingivitis: A Comparative Study. Dentistry (Sunnyvale). 2014 Jun 01; 4(6):239. PMID: 26052472.
      View in: PubMed
    25. Holtzman JS, Ballantine J, Fontana M, Wang A, Calantog A, Benavides E, Gonzalez-Cabezas C, Chen Z, Wilder-Smith P. Assessment of early occlusal caries pre- and post-sealant application--an imaging approach. Lasers Surg Med. 2014 Aug; 46(6):499-507. PMID: 24729412.
      View in: PubMed
    26. Mittal R, Balu M, Wilder-Smith P, Potma EO. Achromatic miniature lens system for coherent Raman scattering microscopy. Biomed Opt Express. 2013; 4(10):2196-206. PMID: 24156075.
      View in: PubMed
    27. Mittal R, Balu M, Krasieva T, Potma EO, Elkeeb L, Zachary CB, Wilder-Smith P. Evaluation of stimulated Raman scattering microscopy for identifying squamous cell carcinoma in human skin. Lasers Surg Med. 2013 Oct; 45(8):496-502. PMID: 23996592.
      View in: PubMed
    28. Calantog A, Hallajian L, Nabelsi T, Mansour S, Le A, Epstein J, Wilder-Smith P. A prospective study to assess in vivo optical coherence tomography imaging for early detection of chemotherapy-induced oral mucositis. Lasers Surg Med. 2013 Jan; 45(1):22-7. PMID: 23322707.
      View in: PubMed
    29. Duong S, Youssef J, Pimenta P, Aguigam H, Zhang J, Calantog A, Pilch S, Masters JG, Wilder-Smith P. An imaging-based approach to the evaluation of xerostomia. Lasers Surg Med. 2012 Aug; 44(6):482-9. PMID: 22693075.
      View in: PubMed
    30. Stoianovici C, Wilder-Smith P, Choi B. Assessment of pulpal vitality using laser speckle imaging. Lasers Surg Med. 2011 Sep; 43(8):833-7. PMID: 21956631.
      View in: PubMed
    31. Zhang Q, Nguyen AL, Shi S, Hill C, Wilder-Smith P, Krasieva TB, Le AD. Three-dimensional spheroid culture of human gingiva-derived mesenchymal stem cells enhances mitigation of chemotherapy-induced oral mucositis. Stem Cells Dev. 2012 Apr 10; 21(6):937-47. PMID: 21689066.
      View in: PubMed
    32. Ahn YC, Chung J, Wilder-Smith P, Chen Z. Multimodality approach to optical early detection and? mapping of oral neoplasia. J Biomed Opt. 2011 Jul; 16(7):076007. PMID: 21806268.
      View in: PubMed
    33. Le A, Messadi D, Epstein J, Wilder-Smith P. Toward multimodality oral cancer diagnosis in the XXI century: Blending cutting edge imaging and genomic/proteomic definition of suspicious lesions. Bioinformation. 2011 Jan 06; 5(7):304-6. PMID: 21364840.
      View in: PubMed
    34. Wilder-Smith P, Holtzman J, Epstein J, Le A. Optical diagnostics in the oral cavity: an overview. Oral Dis. 2010 Nov; 16(8):717-28. PMID: 20561224.
      View in: PubMed
    35. Zhang QZ, Su WR, Shi SH, Wilder-Smith P, Xiang AP, Wong A, Nguyen AL, Kwon CW, Le AD. Human gingiva-derived mesenchymal stem cells elicit polarization of m2 macrophages and enhance cutaneous wound healing. Stem Cells. 2010 Oct; 28(10):1856-68. PMID: 20734355.
      View in: PubMed
    36. Holtzman JS, Osann K, Pharar J, Lee K, Ahn YC, Tucker T, Sabet S, Chen Z, Gukasyan R, Wilder-Smith P. Ability of optical coherence tomography to detect caries beneath commonly used dental sealants. Lasers Surg Med. 2010 Oct; 42(8):752-9. PMID: 20848554.
      View in: PubMed
    37. Kim CS, Ahn YC, Wilder-Smith P, Oh S, Chen Z, Kwon YJ. Efficient and facile delivery of gold nanoparticles in vivo using dissolvable microneedles for contrast-enhanced optical coherence tomography. Biomed Opt Express. 2010 Jul 14; 1(1):106-113. PMID: 21258450.
      View in: PubMed
    38. DeCoro M, Wilder-Smith P. Potential of optical coherence tomography for early diagnosis of oral malignancies. Expert Rev Anticancer Ther. 2010 Mar; 10(3):321-9. PMID: 20214513.
      View in: PubMed
    39. Hammer-Wilson MJ, Nguyen V, Jung WG, Ahn Y, Chen Z, Wilder-Smith P. Detection of vesicant-induced upper airway mucosa damage in the hamster cheek pouch model using optical coherence tomography. J Biomed Opt. 2010 Jan-Feb; 15(1):016017. PMID: 20210463.
      View in: PubMed
    40. Messadi DV, Wilder-Smith P, Wolinsky L. Improving oral cancer survival: the role of dental providers. J Calif Dent Assoc. 2009 Nov; 37(11):789-98. PMID: 19998655.
      View in: PubMed
    41. Wilder-Smith CH, Wilder-Smith P, Kawakami-Wong H, Voronets J, Osann K, Lussi A. Quantification of dental erosions in patients with GERD using optical coherence tomography before and after double-blind, randomized treatment with esomeprazole or placebo. Am J Gastroenterol. 2009 Nov; 104(11):2788-95. PMID: 19654570.
      View in: PubMed
    42. Wilder-Smith P, Lee K, Guo S, Zhang J, Osann K, Chen Z, Messadi D. In vivo diagnosis of oral dysplasia and malignancy using optical coherence tomography: preliminary studies in 50 patients. Lasers Surg Med. 2009 Jul; 41(5):353-7. PMID: 19533765.
      View in: PubMed
    43. Baek JH, Krasieva T, Tang S, Ahn Y, Kim CS, Vu D, Chen Z, Wilder-Smith P. Optical approach to the salivary pellicle. J Biomed Opt. 2009 Jul-Aug; 14(4):044001. PMID: 19725713.
      View in: PubMed
    44. Kim CS, Wilder-Smith P, Ahn YC, Liaw LH, Chen Z, Kwon YJ. Enhanced detection of early-stage oral cancer in vivo by optical coherence tomography using multimodal delivery of gold nanoparticles. J Biomed Opt. 2009 May-Jun; 14(3):034008. PMID: 19566301.
      View in: PubMed
    45. Kawakami-Wong H, Gu S, Hammer-Wilson MJ, Epstein JB, Chen Z, Wilder-Smith P. In vivo optical coherence tomography-based scoring of oral mucositis in human subjects: a pilot study. J Biomed Opt. 2007 Sep-Oct; 12(5):051702. PMID: 17994875.
      View in: PubMed
    46. Hammer-Wilson MJ, Gray RM, Wilder-Smith P, Meister F, Osann K, Wilder-Smith CH. Fluorescence diagnostics of Helicobacter pylori-infected human gastric mucosa: establishing technique and validity. Scand J Gastroenterol. 2007 Aug; 42(8):941-50. PMID: 17613923.
      View in: PubMed
    47. Chung J, Jung W, Hammer-Wilson MJ, Wilder-Smith P, Chen Z. Use of polar decomposition for the diagnosis of oral precancer. Appl Opt. 2007 May 20; 46(15):3038-45. PMID: 17514255.
      View in: PubMed
    48. Wilder-Smith P, Hammer-Wilson MJ, Zhang J, Wang Q, Osann K, Chen Z, Wigdor H, Schwartz J, Epstein J. In vivo imaging of oral mucositis in an animal model using optical coherence tomography and optical Doppler tomography. Clin Cancer Res. 2007 Apr 15; 13(8):2449-54. PMID: 17438104.
      View in: PubMed
    49. Hanna NM, Waite W, Taylor K, Jung WG, Mukai D, Matheny E, Kreuter K, Wilder-Smith P, Brenner M, Chen Z. Feasibility of three-dimensional optical coherence tomography and optical Doppler tomography of malignancy in hamster cheek pouches. Photomed Laser Surg. 2006 Jun; 24(3):402-9. PMID: 16875451.
      View in: PubMed
    50. Wilder-Smith P, Krasieva T, Jung WG, Zhang J, Chen Z, Osann K, Tromberg B. Noninvasive imaging of oral premalignancy and malignancy. J Biomed Opt. 2005 Sep-Oct; 10(5):051601. PMID: 16292949.
      View in: PubMed
    51. Chang CJ, Wilder-Smith P. Topical application of photofrin for photodynamic diagnosis of oral neoplasms. Plast Reconstr Surg. 2005 Jun; 115(7):1877-86. PMID: 15923832.
      View in: PubMed
    52. Matheny ES, Hanna NM, Jung WG, Chen Z, Wilder-Smith P, Mina-Araghi R, Brenner M. Optical coherence tomography of malignancy in hamster cheek pouches. J Biomed Opt. 2004 Sep-Oct; 9(5):978-81. PMID: 15447019.
      View in: PubMed
    53. Wilder-Smith P, Jung WG, Brenner M, Osann K, Beydoun H, Messadi D, Chen Z. In vivo optical coherence tomography for the diagnosis of oral malignancy. Lasers Surg Med. 2004; 35(4):269-75. PMID: 15493024.
      View in: PubMed
    54. Wilder-Smith P, Osann K, Hanna N, El Abbadi N, Brenner M, Messadi D, Krasieva T. In vivo multiphoton fluorescence imaging: a novel approach to oral malignancy. Lasers Surg Med. 2004; 35(2):96-103. PMID: 15334611.
      View in: PubMed
    55. Ebihara A, Krasieva TB, Liaw LH, Fago S, Messadi D, Osann K, Wilder-Smith P. Detection and diagnosis of oral cancer by light-induced fluorescence. Lasers Surg Med. 2003; 32(1):17-24. PMID: 12516066.
      View in: PubMed
    56. Charoenbanpachon S, Krasieva T, Ebihara A, Osann K, Wilder-Smith P. Acceleration of ALA-induced PpIX fluorescence development in the oral mucosa. Lasers Surg Med. 2003; 32(3):185-8. PMID: 12605424.
      View in: PubMed
    57. Wong SF, Wilder-Smith P. Pilot study of laser effects on oral mucositis in patients receiving chemotherapy. Cancer J. 2002 May-Jun; 8(3):247-54. PMID: 12074324.
      View in: PubMed
    58. Ebihara A, Majaron B, Liaw LH, Krasieva TB, Wilder-Smith P. Er:YAG laser modification of root canal dentine: influence of pulse duration, repetitive irradiation and water spray. Lasers Med Sci. 2002; 17(3):198-207. PMID: 12181634.
      View in: PubMed
    59. Wilder-Smith CH, Wilder-Smith P, Grosjean P, van den Bergh H, Woodtli A, Monnier P, Dorta G, Meister F, Wagnières G. Photoeradication of Helicobacter pylori using 5-aminolevulinic acid: preliminary human studies. Lasers Surg Med. 2002; 31(1):18-22. PMID: 12124710.
      View in: PubMed
    60. Arrastia-Jitosho AM, Liaw LH, Lee W, Wilder-Smith P. Effects of a 532 nm Q-switched nanosecond pulsed laser on dentin. J Endod. 1998 Jun; 24(6):427-31. PMID: 9693588.
      View in: PubMed
    61. Dang J, Wilder-Smith P, Peavy GM. Clinical preconditions and treatment modality: effects on pulp surgery outcome. Lasers Surg Med. 1998; 22(1):25-9. PMID: 9443146.
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    62. Chang JC, Wilder-Smith P. Laser-induced thermal events in empty and pulp-filled dental pulp chambers. Lasers Surg Med. 1998; 22(1):46-50. PMID: 9443150.
      View in: PubMed
    63. Wilder-Smith P, Dang J, Kurosaki T, Neev J. The influence of laser parameter configurations at 9.3 microns on incisional and collateral effects in soft tissue. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997 Jul; 84(1):22-7. PMID: 9247944.
      View in: PubMed
    64. Wilder-Smith P, Dang J, Kurosaki T. Investigating the range of surgical effects on soft tissue produced by a carbon dioxide laser. J Am Dent Assoc. 1997 May; 128(5):583-8. PMID: 9150641.
      View in: PubMed
    65. Wilder-Smith P, Lin S, Nguyen A, Liaw LH, Arrastia AM, Lee JP, Berns MW. Morphological effects of ArF excimer laser irradiation on enamel and dentin. Lasers Surg Med. 1997; 20(2):142-8. PMID: 9047167.
      View in: PubMed
    66. Wilder-Smith P, Peavy GM, Nielsen D, Arrastia-Jitosho AM. CO2 laser treatment of traumatic pulpal exposures in dogs. Lasers Surg Med. 1997; 21(5):432-7. PMID: 9365953.
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    67. Wilder-Smith P, Arrastia AM, Schell MJ, Liaw LH, Grill G, Berns MW. Effect of ND:YAG laser irradiation and root planing on the root surface: structural and thermal effects. J Periodontol. 1995 Dec; 66(12):1032-9. PMID: 8683415.
      View in: PubMed
    68. Wilder-Smith P, Arrastia AM, Liaw LH, Berns M. Incision properties and thermal effects of three CO2 lasers in soft tissue. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Jun; 79(6):685-91. PMID: 7621023.
      View in: PubMed
    69. Arrastia AM, Wilder-Smith P, Berns MW. Thermal effects of CO2 laser on the pulpal chamber and enamel of human primary teeth: an in vitro investigation. Lasers Surg Med. 1995; 16(4):343-50. PMID: 7651055.
      View in: PubMed
    70. Wilder-Smith PE. A new method for the non-invasive measurement of pulpal blood flow. Int Endod J. 1988 Sep; 21(5):307-12. PMID: 3074063.
      View in: PubMed