Paul S Sypherd

Title(s)Professor Emeritus, Microbiology and Molecular Genetics
Address1001 Health Sciences Road
Irvine CA 92697-3950
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    Collapse Research 
    Collapse Research Activities and Funding
    NIH R01AI031807May 1, 1992 - Sep 30, 1994
    Role: Co-Principal Investigator
    NIH R01GM047727May 1, 1992 - Sep 30, 1994
    Role: Co-Principal Investigator
    NIH R01AI025788Sep 30, 1987 - Aug 31, 1990
    Role: Principal Investigator
    NIH R01AI020238Sep 30, 1985 - Aug 31, 1990
    Role: Principal Investigator
    NIH R01GM023999Apr 1, 1977 - Nov 30, 1991
    Role: Principal Investigator
    NIH T32GM007134Jul 1, 1975 - Sep 30, 1995
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. HWP1 functions in the morphological development of Candida albicans downstream of EFG1, TUP1, and RBF1. J Bacteriol. 1999 Sep; 181(17):5273-9. Sharkey LL, McNemar MD, Saporito-Irwin SM, Sypherd PS, Fonzi WA. PMID: 10464197.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    2. Use of URA3 as a reporter of gene expression in C. albicans. Curr Genet. 1995 Feb; 27(3):243-8. Myers KK, Sypherd PS, Fonzi WA. PMID: 7736609.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    3. PHR1, a pH-regulated gene of Candida albicans, is required for morphogenesis. Mol Cell Biol. 1995 Feb; 15(2):601-13. Saporito-Irwin SM, Birse CE, Sypherd PS, Fonzi WA. PMID: 7823929.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    4. Cloning and characterization of ECE1, a gene expressed in association with cell elongation of the dimorphic pathogen Candida albicans. Infect Immun. 1993 Sep; 61(9):3648-55. Birse CE, Irwin MY, Fonzi WA, Sypherd PS. PMID: 8359888.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    5. Fungus-specific translation elongation factor 3 gene present in Pneumocystis carinii. Infect Immun. 1992 Oct; 60(10):4140-5. Ypma-Wong MF, Fonzi WA, Sypherd PS. PMID: 1339410.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    6. Isolation and sequence analysis of the gene for translation elongation factor 3 from Candida albicans. Nucleic Acids Res. 1992 Apr 11; 20(7):1705-10. Myers KK, Fonzi WA, Sypherd PS. PMID: 1579463.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    7. Developmental regulation of CUP gene expression through DNA methylation in Mucor spp. J Bacteriol. 1992 Jan; 174(2):362-6. Cano-Canchola C, Sosa L, Fonzi W, Sypherd P, Ruiz-Herrera J. PMID: 1729231.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    8. The isolation and characterization of a calmodulin-encoding gene (CMD1) from the dimorphic fungus Candida albicans. Gene. 1991 Sep 30; 106(1):43-9. Saporito SM, Sypherd PS. PMID: 1937040.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    9. Both genes for EF-1 alpha in Candida albicans are translated. Mol Microbiol. 1991 Jul; 5(7):1703-6. Sundstrom P, Irwin M, Smith D, Sypherd PS. PMID: 1943704.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    10. Sequence analysis and expression of the two genes for elongation factor 1 alpha from the dimorphic yeast Candida albicans. J Bacteriol. 1990 Apr; 172(4):2036-45. Sundstrom P, Smith D, Sypherd PS. PMID: 2180914.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    11. Role of lysine methylation in the activities of elongation factor 1 alpha. Arch Biochem Biophys. 1989 Dec; 275(2):371-8. Sherman M, Sypherd PS. PMID: 2512854.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    12. Structure of a ribosomal protein gene in Mucor racemosus. Nucleic Acids Res. 1989 Nov 25; 17(22):9319-31. Sosa L, Fonzi WA, Sypherd PS. PMID: 2685758.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    13. Cycloheximide efflux in antibiotic-adapted cells of the fungus Mucor racemosus. Antimicrob Agents Chemother. 1988 Mar; 32(3):341-5. Shearer G, Sypherd PS. PMID: 3364951.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    14. Sequence analysis of the EF-1 alpha gene family of Mucor racemosus. Nucleic Acids Res. 1987 Dec 10; 15(23):9997-10006. Sundstrom P, Lira LM, Choi D, Linz JE, Sypherd PS. PMID: 3697088.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    15. The gene and the primary structure of ornithine decarboxylase from Saccharomyces cerevisiae. J Biol Chem. 1987 Jul 25; 262(21):10127-33. Fonzi WA, Sypherd PS. PMID: 3038869.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    16. Expression of three genes for elongation factor 1 alpha during morphogenesis of Mucor racemosus. Mol Cell Biol. 1987 May; 7(5):1925-32. Linz JE, Sypherd PS. PMID: 3037339.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    17. The primary structure and the functional domains of an elongation factor-1 alpha from Mucor racemosus. J Biol Chem. 1986 Nov 15; 261(32):15022-9. Linz JE, Lira LM, Sypherd PS. PMID: 3021762.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    18. Identification of epsilon-N-mono-, epsilon-N-di-, and epsilon-N-trimethyllysine by high-performance liquid chromatography. Appl Environ Microbiol. 1986 Jun; 51(6):1355-7. Garcia R, Hiatt WR, Jasinski S, Sypherd PS. PMID: 3089155.
      View in: PubMed   Mentions: 1     Fields:    
    19. Trichodermin esterase activity and trichodermin resistance in Mucor racemosus. Antimicrob Agents Chemother. 1986 Apr; 29(4):570-5. Fonzi WA, Sypherd PS. PMID: 3707105.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    20. Three genes for the elongation factor EF-1 alpha in Mucor racemosus. Mol Cell Biol. 1986 Feb; 6(2):593-600. Linz JE, Katayama C, Sypherd PS. PMID: 2946933.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    21. Inducible phenotypic multidrug resistance in the fungus Mucor racemosus. Antimicrob Agents Chemother. 1985 Jun; 27(6):892-6. Leathers TD, Sypherd PS. PMID: 4026262.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    22. Regulation of protein synthesis factor EF-1 alpha in Mucor racemosus. Mol Cell Biol. 1985 May; 5(5):1100-3. Fonzi WA, Katayama C, Leathers T, Sypherd PS. PMID: 4000119.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    23. Dispersed repetitive DNA sequence of Mucor racemosus. J Bacteriol. 1985 Apr; 162(1):438-40. Dewar R, Katayama C, Sypherd PS, Cihlar RL. PMID: 3980442.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    24. Expression of the gene for ornithine decarboxylase of Saccharomyces cerevisiae in Escherichia coli. Mol Cell Biol. 1985 Jan; 5(1):161-6. Fonzi WA, Sypherd PS. PMID: 3885007.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    25. Complementation of the leuB6 allele of Escherichia coli by cloned DNA from Mucor racemosus. J Bacteriol. 1982 Jul; 151(1):521-3. Cihlar RL, Sypherd PS. PMID: 7045088.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    26. Methylation of elongation factor 1 alpha from the fungus Mucor. Proc Natl Acad Sci U S A. 1982 Jun; 79(11):3433-7. Hiatt WR, Garcia R, Merrick WC, Sypherd PS. PMID: 6808511.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    27. S-adenosylmethionine levels and protein methylation during morphogenesis of Mucor racemosus. J Bacteriol. 1980 Apr; 142(1):196-201. Garcia JR, Hiatt WR, Peters J, Sypherd PS. PMID: 7372569.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    28. Differential synthesis of polypeptides during morphogenesis of Mucor. J Bacteriol. 1980 Mar; 141(3):1350-9. Hiatt WR, Inderlied CB, Sypherd PS. PMID: 7364729.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    29. The organization of the ribosomal RNA genes in the fungus Mucor racemosus. Nucleic Acids Res. 1980 Feb 25; 8(4):793-804. Cihlar RL, Sypherd PS. PMID: 6253925.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    30. Regulation of ornithine decarboxylase during morphogenesis of Mucor racemosus. J Bacteriol. 1980 Feb; 141(2):699-706. Inderlied CB, Cihlar RL, Sypherd PS. PMID: 6245054.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    31. Physiological control of phosphorylation ribosomal protein S6 in Mucor racemosus. J Bacteriol. 1980 Jan; 141(1):20-5. Larsen A, Sypherd PS. PMID: 7353998.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    32. Ribosomal proteins of the dimorphic fungus, Mucor racemosus. Mol Gen Genet. 1979 Aug; 175(1):99-109. Larsen A, Sypherd P. PMID: 292824.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    33. Morphology-associated expression nicotinamide adenine dinucleotide-dependent glutamate dehydrogenase in Mucorracemosus. J Bacteriol. 1979 Mar; 137(3):1134-9. Peters J, Sypherd PS. PMID: 35513.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    34. RNA synthesis during morphogenesis of the fungus Mucor racemosus. Arch Microbiol. 1978 Nov 13; 119(2):145-52. Orlowski M, Sypherd PS. PMID: 727853.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    35. Regulation of macromolecular synthesis during hyphal germ tube emergence from Mucor racemosus sporangiospores. J Bacteriol. 1978 Apr; 134(1):76-83. Orlowski M, Sypherd PS. PMID: 649573.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    36. Glucose metabolism and dimorphism in Mucor. J Bacteriol. 1978 Mar; 133(3):1282-6. Inderlied CB, Sypherd PS. PMID: 641009.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    37. Regulation of translation rate during morphogenesis in the fungus Mucor. Biochemistry. 1978 Feb 21; 17(4):569-75. Orlowski M, Sypherd PS. PMID: 623731.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    38. Location of protein synthesis during morphogenesis of Mucor racemosus. J Bacteriol. 1978 Jan; 133(1):399-400. Orlowski M, Sypherd PS. PMID: 618844.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    39. Biochemistry of dimorphism in the fungus Mucor. Adv Microb Physiol. 1978; 18:67-104. Sypherd PS, Borgia PT, Paznokas JL. PMID: 380311.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    40. Protein synthesis during morphogenesis of Mucor racemosus. J Bacteriol. 1977 Oct; 132(1):209-18. Orlowski M, Sypherd PS. PMID: 914775.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    41. Pyruvate kinase isozymes of Mucor racemosus: control of synthesis by glucose. J Bacteriol. 1977 May; 130(2):661-6. Paznokas JL, Sypherd PS. PMID: 233718.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    42. Control of beta-glucosidase synthesis in Mucor racemosus. J Bacteriol. 1977 May; 130(2):812-7. Borgia P, Sypherd PS. PMID: 233721.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    43. Volatile factor involved in the dimorphism of Mucor racemosus. J Bacteriol. 1976 Jun; 126(3):1266-70. Mooney DT, Sypherd PS. PMID: 947889.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    44. Cyclic guanosine 3',5'-monophosphate in the dimorphic fungus Mucor racemosus. J Bacteriol. 1976 Mar; 125(3):1226-8. Orlowski M, Sypherd PS. PMID: 176140.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    45. Respiratory capacity, cyclic adenosine 3',5'-monophosphate, and morphogenesis of Mucor racemosus. J Bacteriol. 1975 Oct; 124(1):134-9. Paznokas JL, Sypherd PS. PMID: 170243.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    46. Temperature dependence for physical and functional reconstitution of 30S ribosomes of E. coli. Biochem Biophys Res Commun. 1975 Sep 16; 66(2):570-7. Wireman JW, Sypherd PS. PMID: 1101889.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    47. Studies on the structure and function of ribosomes from regenerating rat liver. Biochem Biophys Res Commun. 1974 Nov 06; 61(1):322-8. Scheinbuks J, Sypherd PS, Moldave K. PMID: 4441400.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    48. Ribosomal proteins and ribonucleic acids of ribosome maturation mutants of Escherichia coli. Biochemistry. 1974 May 07; 13(10):2110-4. Bryant RE, Fujisawa T, Sypherd PS. PMID: 4597071.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    49. Properties of 30S ribosomal particles reconstituted from precursor 16S ribonucleic acid. Biochemistry. 1974 Mar 12; 13(6):1215-21. Wireman JW, Sypherd PS. PMID: 4592471.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    50. Genetic analysis of cold-sensitive ribosome maturation mutants of Escherichia coli. J Bacteriol. 1974 Mar; 117(3):1082-92. Bryant RE, Sypherd PS. PMID: 4591943.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    51. In vitro assembly of 30S ribosomal particles from precursor 16S RNA of Escherichia coli. Nature. 1974 Feb 22; 247(5442):552-4. Wireman JW, Sypherd PS. PMID: 4594437.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    52. Cyclic adenosine 3',5'-monophosphate and morphogenesis in Mucor racemosus. J Bacteriol. 1974 Feb; 117(2):432-8. Larsen AD, Sypherd PS. PMID: 4359645.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    53. Preparation of ribosomal subunits by large-scale zonal centrifugation. Methods Enzymol. 1974; 30:349-54. Sypherd PS, Wireman JW. PMID: 4604935.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    54. Genetic control of ribosome assembly. J Supramol Struct. 1974; 2(2-4):166-77. Sypherd PS, Bryant R, Dimmitt K, Fujisawa T. PMID: 4612243.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    55. Association of lysozyme with ribosomes and ribosome precursor particles. J Bacteriol. 1973 Nov; 116(2):1059-61. Dimmitt K, Sypherd PS. PMID: 4583231.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    56. Topography of the Escherichia coli 30 S ribosome revealed by the modification of ribosomal proteins. J Mol Biol. 1973 Aug 15; 78(3):539-50. Miller RV, Sypherd PS. PMID: 4585328.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    57. Chemical and enzymatic modification of proteins in the 30 S ribosome of Escherichia coli. J Mol Biol. 1973 Aug 15; 78(3):527-38. Miller RV, Sypherd PS. PMID: 4585327.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    58. Comparative chemistry of 30S ribosomal proteins of Salmonella typhimurium. J Bacteriol. 1972 Apr; 110(1):300-5. Huang J, Sypherd PS. PMID: 4552994.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    59. Analysis for antigenic similarities among the 30S ribosomal proteins of Escherichia coli. J Bacteriol. 1971 Nov; 108(2):910-5. Strnad BC, Sypherd PS. PMID: 4942770.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    60. Ribosomal proteins and the conformation of ribosomal ribonucleic acid. J Mol Biol. 1971 Mar 14; 56(2):311-8. Sypherd PS. PMID: 4323930.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    61. Cotransduction of strA and ribosomal protein cistrons in Escherichia coli-Salmonella typhimurium hybrids. J Bacteriol. 1971 Mar; 105(3):947-56. O'Neil DM, Sypherd PS. PMID: 4929285.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    62. Absence of thiolated nucleotides in ribosomal RNA of E. coli. Biochem Biophys Res Commun. 1970 Dec 09; 41(5):1328-34. Champney WS, Sypherd PS. PMID: 4921759.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    63. Amino acid differences in a 30S ribosomal protein from two strains of Escherichia coli. J Bacteriol. 1969 Aug; 99(2):379-82. Sypherd PS. PMID: 4897107.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    64. Escherichia coli: reversion from streptomycin dependence, a mutation in a specific 30 s ribosomal protein. J Mol Biol. 1969 Jul 28; 43(2):327-9. Apirion D, Schlessinger D, Phillips S, Sypherd P. PMID: 4896375.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    65. Chromosomal location of ribosomal protein cistrons determined by intergeneric bacterial mating. J Bacteriol. 1969 Jul; 99(1):242-7. O'Neil DM, Baron LS, Sypherd PS. PMID: 4895845.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    66. Unique protein moieties for 30S and 50S ribosomes of Escherichia coli. J Bacteriol. 1969 Jun; 98(3):1080-6. Strnad BC, Sypherd PS. PMID: 4892365.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    67. Isolation and amino acid composition of ribosomal proteins from Bacillus stearothermophilus. J Bacteriol. 1969 May; 98(2):568-72. Ansley SB, Campbell LL, Sypherd PS. PMID: 4891258.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    68. The chemical and genetic structure of bacterial ribosomes. Cold Spring Harb Symp Quant Biol. 1969; 34:77-84. Sypherd PS, O'Neil DM, Taylor MM. PMID: 4909531.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    69. Changes in soluble RNA and ribonuclease activity during germination of wheat. Plant Physiol. 1968 Aug; 43(8):1221-6. Vold BS, Sypherd PS. PMID: 5700016.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    70. Extraction and isolation of individual ribosomal proteins from Escherichia coli. J Bacteriol. 1968 Aug; 96(2):358-64. Fogel S, Sypherd PS. PMID: 4877123.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    71. Ribosome development and the methylation of ribosomal ribonucleic acid. J Bacteriol. 1968 May; 95(5):1844-50. Sypherd PS. PMID: 4870284.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    72. Chemical basis for heterogeneity of ribosomal proteins. Proc Natl Acad Sci U S A. 1968 Apr; 59(4):1329-36. Fogel S, Sypherd PS. PMID: 4870863.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    73. Modification in transfer RNA during the differentiation of wheat seedlings. Proc Natl Acad Sci U S A. 1968 Feb; 59(2):453-8. Vold BS, Sypherd PS. PMID: 5238976.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    74. Message activity of RNA derived from immature ribosomes. J Mol Biol. 1967 Mar 14; 24(2):329-32. Sypherd PS. PMID: 5339875.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    75. Structural transitions in ribonucleic acid during ribosome development. J Bacteriol. 1967 Mar; 93(3):920-9. Sypherd PS, Fansler BS. PMID: 5337839.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    76. Site of synthesis of ribosomal proteins. J Mol Biol. 1966 Jun; 17(2):358-69. Sypherd PS. PMID: 5336322.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
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    80. THE ROLE OF RNA IN REPRESSION OF ENZYME SYNTHESIS. Proc Natl Acad Sci U S A. 1963 Dec; 50:1059-66. SYPHERD PS, STRAUSS N. PMID: 14096178.
      View in: PubMed   Mentions:
    81. CHLORAMPHENICOL-PROMOTED REPRESSION OF beta-GALACTOSIDASE SYNTHESIS IN ESCHERICHIA COLI. Proc Natl Acad Sci U S A. 1963 Mar; 49(3):400-7. Sypherd PS, Strauss N. PMID: 16591059.
      View in: PubMed   Mentions:
    82. The effects of riboflavin deficiency on phagocytosis and susceptibility to infection. J Immunol. 1960 Nov; 85:511-5. WERTMAN KF, SYPHERD PS. PMID: 13784530.
      View in: PubMed   Mentions:
    83. Mosses as Possible Sources of Antibiotics. Science. 1960 Jan 08; 131(3393):108. McCleary JA, Sypherd PS, Walkington DL. PMID: 17797799.
      View in: PubMed   Mentions:
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