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Syrbactin-class dual constitutive- and immuno-proteasome inhibitor TIR-199 impedes myeloma-mediated bone degeneration in vivo. Biosci Rep. 2022 02 25; 42(2).
Tandon V, Vala RM, Chen A, Sah RL, Patel HM, Pirrung MC, Banerjee S. PMID: 35088066; PMCID: PMC8837819.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Concentrations of Tire Additive Chemicals and Tire Road Wear Particles in an Australian Urban Tributary. Environ Sci Technol. 2022 02 15; 56(4):2421-2431.
Rauert C, Charlton N, Okoffo ED, Stanton RS, Agua AR, Pirrung MC, Thomas KV. PMID: 35099932.
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PubMed Mentions:
8 Fields:
Translation:
PHPublic Health
-
Cannabichromene Racemization and Absolute Stereochemistry Based on a Cannabicyclol Analog. J Org Chem. 2021 06 18; 86(12):8036-8040.
Agua AR, Barr PJ, Marlowe CK, Pirrung MC. PMID: 34078070.
View in:
PubMed Mentions:
2 Fields:
Translation:
Animals
-
Spider web biomonitoring: A cost-effective source apportionment approach for urban particulate matter. Environ Pollut. 2021 Oct 01; 286:117328.
van Laaten N, von Tümpling W, Merten D, Bro R, Schäfer T, Pirrung M. PMID: 33990052.
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PubMed Mentions: Fields:
Translation:
AnimalsPHPublic Health
-
Synthetic Access to Cannabidiol and Analogs as Active Pharmaceutical Ingredients. J Med Chem. 2020 11 12; 63(21):12131-12136.
Pirrung MC. PMID: 32531156.
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PubMed Mentions:
3 Fields:
Translation:
Animals
-
Syrbactin proteasome inhibitor TIR-199 overcomes bortezomib chemoresistance and inhibits multiple myeloma tumor growth in vivo. Leuk Res. 2020 01; 88:106271.
Pierce MR, Robinson RM, Ibarra-Rivera TR, Pirrung MC, Dolloff NG, Bachmann AS. PMID: 31778912; PMCID: PMC6937391.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Synthesis and bioluminescence of thioluciferin. Bioorg Med Chem Lett. 2019 10 01; 29(19):126591.
Pirrung MC, Carlson AD, De Howitt N, Liao J. PMID: 31471166.
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PubMed Mentions: Fields:
Translation:
Animals
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Thiasyrbactins Induce Cell Death via Proteasome Inhibition in Multiple Myeloma Cells. Anticancer Res. 2018 Oct; 38(10):5607-5613.
Pierce MR, Bakas NA, Pirrung MC, Bachmann AS. PMID: 30275178.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Immunoproteasome inhibition and bioactivity of thiasyrbactins. Bioorg Med Chem. 2018 01 15; 26(2):401-412.
Bakas NA, Schultz CR, Yco LP, Roberts CC, Chang CA, Bachmann AS, Pirrung MC. PMID: 29269255; PMCID: PMC5920785.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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β-Deuterium Isotope Effects on Firefly Luciferase Bioluminescence. ChemistryOpen. 2017 12; 6(6):697-700.
Pirrung MC, Dorsey A, Howitt N, Liao J. PMID: 29226056; PMCID: PMC5715289.
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PubMed Mentions:
3 Fields:
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Native Serine Peptide Assembly: Scope and Utility. European J Org Chem. 2016 Dec; 2016(34):5633-5636.
Pirrung MC, Schreihans RS. PMID: 28111523; PMCID: PMC5241111.
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PubMed Mentions:
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Correction: Total synthesis of fellutamides, lipopeptide proteasome inhibitors. More sustainable peptide bond formation. Org Biomol Chem. 2016 09 26; 14(38):9159.
Pirrung MC, Zhang F, Ambadi S, Gangadhara Rao Y. PMID: 27714303.
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PubMed Mentions: Fields:
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Total synthesis of fellutamides, lipopeptide proteasome inhibitors. More sustainable peptide bond formation. Org Biomol Chem. 2016 Sep 21; 14(35):8367-75.
Pirrung MC, Zhang F, Ambadi S, Gangadhara Rao Y. PMID: 27533920; PMCID: PMC5303010.
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PubMed Mentions:
4 Fields:
Translation:
Cells
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Syrbactin Structural Analog TIR-199 Blocks Proteasome Activity and Induces Tumor Cell Death. J Biol Chem. 2016 Apr 15; 291(16):8350-62.
Bachmann AS, Opoku-Ansah J, Ibarra-Rivera TR, Yco LP, Ambadi S, Roberts CC, Chang CE, Pirrung MC. PMID: 26907687; PMCID: PMC4861411.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Synthesis and bioluminescence of difluoroluciferin. Bioorg Med Chem Lett. 2014 Oct 15; 24(20):4881-3.
Pirrung MC, Biswas G, De Howitt N, Liao J. PMID: 25239851.
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PubMed Mentions:
5 Fields:
Translation:
Cells
-
The genesis of microarrays. Biochem Mol Biol Educ. 2014 Mar-Apr; 42(2):106-13.
Pirrung MC, Southern EM. PMID: 24344052.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Catalyzed Claisen rearrangements of O-allyl kojates. Tetrahedron Lett. 2013 Jul 17; 54(29).
Pirrung MC, Nalbandian JN. PMID: 24187389; PMCID: PMC3812250.
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PubMed Mentions:
1 Fields:
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Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I. PLoS One. 2013; 8(6):e65695.
Thomas S, Sharma N, Gonzalez R, Pao PW, Hofman FM, Chen TC, Louie SG, Pirrung MC, Schönthal AH. PMID: 23755268; PMCID: PMC3675020.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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A fluorescent amino acid probe to monitor efficiency of peptide conjugation to glass surfaces for high density microarrays. Mol Biosyst. 2012 Mar; 8(3):879-87.
Zhao Y, Pirrung MC, Liao J. PMID: 22241083.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Syringolin B-inspired proteasome inhibitor analogue TIR-203 exhibits enhanced biological activity in multiple myeloma and neuroblastoma. Pharm Biol. 2012 Jan; 50(1):25-9.
Opoku-Ansah J, Ibarra-Rivera TR, Pirrung MC, Bachmann AS. PMID: 22196580.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Novel proteasome-inhibitory syrbactin analogs inducing endoplasmic reticulum stress and apoptosis in hematological tumor cell lines. Biochem Pharmacol. 2011 Sep 15; 82(6):600-9.
Anshu A, Thomas S, Agarwal P, Ibarra-Rivera TR, Pirrung MC, Schönthal AH. PMID: 21736873.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Sensitized two-photon photochemical deprotection. Chem Commun (Camb). 2010 Aug 07; 46(29):5313-5.
Pirrung MC, Dore TM, Zhu Y, Rana VS. PMID: 20552130.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Total synthesis of syringolin A and B. Org Lett. 2010 May 21; 12(10):2402-5.
Pirrung MC, Biswas G, Ibarra-Rivera TR. PMID: 20426399.
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PubMed Mentions:
13 Fields:
Translation:
Cells
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His-tags lighten up and lose their inhibitions. Proc Natl Acad Sci U S A. 2010 Apr 06; 107(14):6123-4.
Pirrung MC. PMID: 20363960; PMCID: PMC2851963.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Iodine scanning of a phenazine inhibitor of vacuolar sorting. Bioorg Med Chem Lett. 2010 Mar 01; 20(5):1496-9.
Surpin M, Zou Y, Xiong C, Raikhel NV, Pirrung MC. PMID: 20153185.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Multicomponent reactions of convertible isonitriles. J Org Chem. 2009 Jun 05; 74(11):4110-7.
Pirrung MC, Ghorai S, Ibarra-Rivera TR. PMID: 19408909.
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PubMed Mentions:
11 Fields:
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Multicomponent reactions of cyclobutanones. J Org Chem. 2009 Apr 17; 74(8):2958-63.
Pirrung MC, Wang J. PMID: 19354324.
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PubMed Mentions:
2 Fields:
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Small molecule activators of the Trk receptors for neuroprotection. BMC Neurosci. 2008 Dec 03; 9 Suppl 2:S1.
Webster NJ, Pirrung MC. PMID: 19090982; PMCID: PMC2604901.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Hydrophobicity and mixing effects on select heterogeneous, water-accelerated synthetic reactions. J Org Chem. 2008 Nov 21; 73(22):8723-30.
Pirrung MC, Das Sarma K, Wang J. PMID: 18954111.
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PubMed Mentions:
10 Fields:
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Ethylene receptor antagonists: strained alkenes are necessary but not sufficient. Chem Biol. 2008 Apr; 15(4):313-21.
Pirrung MC, Bleecker AB, Inoue Y, Rodríguez FI, Sugawara N, Wada T, Zou Y, Binder BM. PMID: 18420138.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Preparation of methyl ester precursors of biologically active agents. Biotechniques. 2008 Mar; 44(3):377-84.
Zou Y, Rojas-Pierce M, Raikhel N, Pirrung M. PMID: 18361791.
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PubMed Mentions: Fields:
Translation:
Cells
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Modular synthesis of candidate indole-based insulin mimics by Claisen rearrangement. Org Lett. 2008 Mar 20; 10(6):1151-4.
Xiong X, Pirrung MC. PMID: 18303898.
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PubMed Mentions:
9 Fields:
Translation:
Cells
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Quinone replacements for small molecule insulin mimics. Chembiochem. 2008 Feb 15; 9(3):360-2.
Pirrung MC, Deng L, Lin B, Webster NJ. PMID: 18232038.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Identification of novel orally available small molecule insulin mimetics. J Pharmacol Exp Ther. 2007 Nov; 323(2):579-85.
Lin B, Li Z, Park K, Deng L, Pai A, Zhong L, Pirrung MC, Webster NJ. PMID: 17687071.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Glyceraldehyde 3-phosphate dehydrogenase is a cellular target of the insulin mimic demethylasterriquinone B1. J Med Chem. 2007 Jul 26; 50(15):3423-6.
Kim H, Deng L, Xiong X, Hunter WD, Long MC, Pirrung MC. PMID: 17595071; PMCID: PMC2556249.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Parallel synthesis of indolylquinones and their cell-based insulin mimicry. J Comb Chem. 2007 Sep-Oct; 9(5):844-54.
Pirrung MC, Li Z, Hensley E, Liu Y, Tanksale A, Lin B, Pai A, Webster NJ. PMID: 17595147.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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Practical synthesis of 7-prenylindole. J Org Chem. 2007 Jul 20; 72(15):5832-4.
Xiong X, Pirrung MC. PMID: 17580906; PMCID: PMC2556248.
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PubMed Mentions:
1 Fields:
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Neuroprotection by small molecule activators of the nerve growth factor receptor. J Pharmacol Exp Ther. 2007 Jul; 322(1):59-69.
Lin B, Pirrung MC, Deng L, Li Z, Liu Y, Webster NJ. PMID: 17468299.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Versatile, fragrant, convertible isonitriles. J Am Chem Soc. 2006 Sep 13; 128(36):11772-3.
Pirrung MC, Ghorai S. PMID: 16953613.
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PubMed Mentions:
9 Fields:
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Mechanistic studies on the photochemical deprotection of 3',5'-dimethoxybenzoin esters. Photochem Photobiol. 2006 Sep-Oct; 82(5):1258-64.
Pirrung MC, Ye T, Zhou Z, Simon JD. PMID: 16752957.
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PubMed Mentions:
2 Fields:
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Molecular validation of LpxC as an antibacterial drug target in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2006 Jun; 50(6):2178-84.
Mdluli KE, Witte PR, Kline T, Barb AW, Erwin AL, Mansfield BE, McClerren AL, Pirrung MC, Tumey LN, Warrener P, Raetz CR, Stover CK. PMID: 16723580; PMCID: PMC1479155.
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PubMed Mentions:
37 Fields:
Translation:
Cells
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Acceleration of organic reactions through aqueous solvent effects. Chemistry. 2006 Feb 01; 12(5):1312-7.
Pirrung MC. PMID: 16189838.
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PubMed Mentions:
15 Fields:
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Adding precision tools to the plant biologists' toolbox with chemical genomics. Plant Physiol. 2005 Jun; 138(2):563-4.
Raikhel N, Pirrung M. PMID: 15955916; PMCID: PMC1150372.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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Combinatorial optimization of isatin-beta-thiosemicarbazones as anti-poxvirus agents. J Med Chem. 2005 Apr 21; 48(8):3045-50.
Pirrung MC, Pansare SV, Sarma KD, Keith KA, Kern ER. PMID: 15828843.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Methyl scanning: total synthesis of demethylasterriquinone B1 and derivatives for identification of sites of interaction with and isolation of its receptor(s). J Am Chem Soc. 2005 Apr 06; 127(13):4609-24.
Pirrung MC, Liu Y, Deng L, Halstead DK, Li Z, May JF, Wedel M, Austin DA, Webster NJ. PMID: 15796526.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Organometallic routes to 2,5-dihydroxy-3-(indol-3-yl)benzoquinones. Synthesis of demethylasterriquinone B4. J Org Chem. 2005 Apr 01; 70(7):2537-42.
Pirrung MC, Fujita K, Park K. PMID: 15787540.
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PubMed Mentions:
4 Fields:
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Benzo[c]phenanthrene adducts and nogalamycin inhibit DNA transesterification by vaccinia topoisomerase. J Biol Chem. 2004 May 28; 279(22):23335-42.
Yakovleva L, Handy CJ, Sayer JM, Pirrung M, Jerina DM, Shuman S. PMID: 15044474.
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PubMed Mentions:
4 Fields:
Translation:
Cells
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Multicomponent reactions are accelerated in water. J Am Chem Soc. 2004 Jan 21; 126(2):444-5.
Pirrung MC, Sarma KD. PMID: 14719923.
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PubMed Mentions:
33 Fields:
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Combinatorial discovery of two-photon photoremovable protecting groups. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12548-53.
Pirrung MC, Pieper WH, Kaliappan KP, Dhananjeyan MR. PMID: 14557545; PMCID: PMC240653.
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PubMed Mentions:
1 Fields:
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Inhibition of Cdc25 phosphatases by indolyldihydroxyquinones. J Med Chem. 2003 Jun 19; 46(13):2580-8.
Sohn J, Kiburz B, Li Z, Deng L, Safi A, Pirrung MC, Rudolph J. PMID: 12801222.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Modular, parallel synthesis of an illudinoid combinatorial library. Org Lett. 2003 May 29; 5(11):1983-5.
Pirrung MC, Liu H. PMID: 12762702.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Signaling effects of demethylasterriquinone B1, a selective insulin receptor modulator. Chembiochem. 2003 May 09; 4(5):379-85.
Webster NJ, Park K, Pirrung MC. PMID: 12740809.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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High-throughput catch-and-release synthesis of oxazoline hydroxamates. Structure-activity relationships in novel inhibitors of Escherichia coli LpxC: in vitro enzyme inhibition and antibacterial properties. J Am Chem Soc. 2003 Feb 12; 125(6):1575-86.
Pirrung MC, Tumey LN, McClerren AL, Raetz CR. PMID: 12568618.
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PubMed Mentions:
13 Fields:
Translation:
Cells
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Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): isoxazoline zinc amidase inhibitors bearing diverse metal binding groups. J Med Chem. 2002 Sep 12; 45(19):4359-70.
Pirrung MC, Tumey LN, Raetz CR, Jackman JE, Snehalatha K, McClerren AL, Fierke CA, Gantt SL, Rusche KM. PMID: 12213077.
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PubMed Mentions:
15 Fields:
Translation:
Cells
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(19)F-encoded combinatorial libraries: discovery of selective metal binding and catalytic peptoids. J Comb Chem. 2002 Jul-Aug; 4(4):329-44.
Pirrung MC, Park K, Tumey LN. PMID: 12099851.
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PubMed Mentions:
8 Fields:
Translation:
Cells
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Arrayed primer extension computing with variant mRNA splice forms. Multiple isoforms of CD44 in a human breast tumor. J Am Chem Soc. 2002 May 08; 124(18):4934-5.
Kim H, Pirrung MC. PMID: 11982338.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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How to make a DNA chip. Angew Chem Int Ed Engl. 2002 Apr 15; 41(8):1276-89.
Pirrung MC. PMID: 19750752.
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PubMed Mentions:
41 Fields:
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Solid-phase, single nucleotide primer extension of DNA/RNA hybrids by reverse transcriptases. Bioorg Med Chem Lett. 2001 Sep 17; 11(18):2437-40.
Pirrung MC, Worden JD, Labriola JP, Montague-Smith MP, Weislo LJ. PMID: 11549441.
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PubMed Mentions: Fields:
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APEX disease gene resequencing: mutations in exon 7 of the p53 tumor suppressor gene. Bioorg Med Chem. 2001 Sep; 9(9):2269-78.
Shumaker JM, Tollet JJ, Filbin KJ, Montague-Smith MP, Pirrung MC. PMID: 11553465.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Photochemically removable silyl protecting groups. J Am Chem Soc. 2001 Apr 25; 123(16):3638-43.
Pirrung MC, Fallon L, Zhu J, Lee YR. PMID: 11457095.
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PubMed Mentions:
5 Fields:
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3'-nitrophenylpropyloxycarbonyl (NPPOC) protecting groups for high-fidelity automated 5' --> 3' photochemical DNA synthesis. Org Lett. 2001 Apr 19; 3(8):1105-8.
Pirrung MC, Wang L, Montague-Smith MP. PMID: 11348170.
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PubMed Mentions:
11 Fields:
Translation:
Cells
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A universal, photocleavable DNA base: nitropiperonyl 2'-deoxyriboside. J Org Chem. 2001 Mar 23; 66(6):2067-71.
Pirrung MC, Zhao X, Harris SV. PMID: 11300902.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Synthesis of 3-indolyl-2,5-dihydroxybenzoquinones. Org Lett. 2001 Feb 08; 3(3):365-7.
Pirrung MC, Park K, Li Z. PMID: 11428015.
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PubMed Mentions:
6 Fields:
-
Trityl isothiocyanate support for solid-phase synthesis. J Comb Chem. 2001 Jan-Feb; 3(1):90-6.
Pirrung MC, Pansare SV. PMID: 11148069.
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PubMed Mentions:
1 Fields:
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Thiophosphorylation of histidine. J Org Chem. 2000 Dec 15; 65(25):8448-53.
Pirrung MC, James KD, Rana VS. PMID: 11112562.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Oxazoline synthesis from hydroxyamides by resin capture and ring-forming release. J Comb Chem. 2000 Nov-Dec; 2(6):675-80.
Pirrung MC, Tumey LN. PMID: 11126295.
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PubMed Mentions:
4 Fields:
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Available pathways database (APD): an essential resource for combinatorial biology. J Nat Prod. 2000 Oct; 63(10):1400-5.
Pirrung MC, Silva CM, Jaeger J. PMID: 11076562.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Discovery of selective metal-binding peptoids using 19F encoded combinatorial libraries. Bioorg Med Chem Lett. 2000 Sep 18; 10(18):2115-8.
Pirrung MC, Park K. PMID: 10999483.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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Antibacterial agents that target lipid A biosynthesis in gram-negative bacteria. Inhibition of diverse UDP-3-O-(r-3-hydroxymyristoyl)-n-acetylglucosamine deacetylases by substrate analogs containing zinc binding motifs. J Biol Chem. 2000 Apr 14; 275(15):11002-9.
Jackman JE, Fierke CA, Tumey LN, Pirrung M, Uchiyama T, Tahir SH, Hindsgaul O, Raetz CR. PMID: 10753902.
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PubMed Mentions:
49 Fields:
Translation:
Cells
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Synthesis of (+/-)-homohistidine. J Org Chem. 2000 Apr 07; 65(7):2229-30.
Pirrung MC, Pei T. PMID: 10774052.
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PubMed Mentions:
4 Fields:
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Dipolar cycloaddition of rhodium-generated carbonyl ylides with p-quinones. Org Lett. 2000 Feb 10; 2(3):353-5.
Pirrung MC, Kaliappan KP. PMID: 10814321.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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Pentadienylnitrobenzyl and Pentadienylnitropiperonyl Photochemically Removable Protecting Groups. J Org Chem. 1999 Jul 09; 64(14):5042-5047.
Pirrung MC, Lee YR, Park K, Springer JB. PMID: 34237832.
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PubMed Mentions:
2 Fields:
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Histidine kinases and two-component signal transduction systems. Chem Biol. 1999 Jun; 6(6):R167-75.
Pirrung MC. PMID: 10375545.
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PubMed Mentions:
9 Fields:
Translation:
Cells
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Ethylene biosynthesis: processing of a substrate analog supports a radical mechanism for the ethylene-forming enzyme. Chem Biol. 1998 Jan; 5(1):49-57.
Pirrung MC, Cao J, Chen J. PMID: 9479479.
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PubMed Mentions:
7 Fields:
Translation:
Animals
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A general method for the spatially defined immobilization of biomolecules on glass surfaces using "caged" biotin. Bioconjug Chem. 1996 May-Jun; 7(3):317-21.
Pirrung MC, Huang CY. PMID: 8816954.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Discovery of a novel tetrahydroacridine acetylcholinesterase inhibitor through an indexed combinatorial library. Chem Biol. 1995 Sep; 2(9):621-6.
Pirrung MC, Chau JH, Chen J. PMID: 9383467.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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Purification and properties of the apple fruit ethylene-forming enzyme. Biochemistry. 1993 Jul 27; 32(29):7445-50.
Pirrung MC, Kaiser LM, Chen J. PMID: 8338842.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Light-directed, spatially addressable parallel chemical synthesis. Science. 1991 Feb 15; 251(4995):767-73.
Fodor SP, Read JL, Pirrung MC, Stryer L, Lu AT, Solas D. PMID: 1990438.
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PubMed Mentions:
339 Fields:
Translation:
Cells
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Intramolecular generation and [2,3]-sigmatropic rearrangement of oxonium ylides. J Am Chem Soc. 1986 Sep 01; 108(19):6060-2.
Pirrung MC, Werner JA. PMID: 22175384.
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PubMed Mentions:
8 Fields: