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Alkire, Michael T.

TitleProfessor In Residence
InstitutionUniversity of California, Irvine
DepartmentAnesthesiology and Perioperative Care
Address1001 Health Sciences Road
CA 92697-3950
Phone(714) 456-5501
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    Collapse Research 
    Collapse Research Activities and Funding
    Developing Anesthesia as PTSD Treatment
    NIH/NIMH R34MH087390Sep 24, 2009 - Apr 30, 2013
    Role: Principal Investigator
    The Role of the Amygdala in Anesthetic-Induced Amnesia
    NIH/NIGMS R01GM065212Jan 1, 2003 - Dec 31, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Mortensen KN, Gjedde A, Thompson GJ, Herman P, Parent MJ, Rothman DL, Kupers R, Ptito M, Stender J, Laureys S, Riedl V, Alkire M, Hyder F. Impact of Global Mean Normalization on Regional Glucose Metabolism in the Human Brain. Neural Plast. 2018; 2018:6120925. PMID: 30008742.
      View in: PubMed
    2. Scheinin H, Alkire EC, Scheinin A, Alkire M, Kantonen O, Långsjö J. Using Positron Emission Tomography in Revealing the Mystery of General Anesthesia: Study Design Challenges and Opportunities. Methods Enzymol. 2018; 603:279-303. PMID: 29673531.
      View in: PubMed
    3. Lioudyno MI, Birch AM, Tanaka BS, Sokolov Y, Goldin AL, Chandy KG, Hall JE, Alkire M. Shaker-related potassium channels in the central medial nucleus of the thalamus are important molecular targets for arousal suppression by volatile general anesthetics. J Neurosci. 2013 Oct 09; 33(41):16310-22. PMID: 24107962; PMCID: PMC3792466.
    4. Mashour GA, Alkire M. Evolution of consciousness: phylogeny, ontogeny, and emergence from general anesthesia. Proc Natl Acad Sci U S A. 2013 Jun 18; 110 Suppl 2:10357-64. PMID: 23754370; PMCID: PMC3690605.
    5. Mashour GA, Alkire M. Consciousness, anesthesia, and the thalamocortical system. Anesthesiology. 2013 Jan; 118(1):13-5. PMID: 23208518.
      View in: PubMed
    6. Hayama HR, Drumheller KM, Mastromonaco M, Reist C, Cahill LF, Alkire M. Event-related functional magnetic resonance imaging of a low dose of dexmedetomidine that impairs long-term memory. Anesthesiology. 2012 Nov; 117(5):981-95. PMID: 22929730; PMCID: PMC3482301.
    7. Lioudyno MI, Broccio M, Sokolov Y, Rasool S, Wu J, Alkire M, Liu V, Kozak JA, Dennison PR, Glabe CG, Lösche M, Hall JE. Effect of synthetic aß peptide oligomers and fluorinated solvents on Kv1.3 channel properties and membrane conductance. PLoS One. 2012; 7(4):e35090. PMID: 22563377; PMCID: PMC3338507.
    8. Långsjö JW, Alkire M, Kaskinoro K, Hayama H, Maksimow A, Kaisti KK, Aalto S, Aantaa R, Jääskeläinen SK, Revonsuo A, Scheinin H. Returning from oblivion: imaging the neural core of consciousness. J Neurosci. 2012 Apr 04; 32(14):4935-43. PMID: 22492049.
      View in: PubMed
    9. Alkire M, Asher CD, Franciscus AM, Hahn EL. Thalamic microinfusion of antibody to a voltage-gated potassium channel restores consciousness during anesthesia. Anesthesiology. 2009 Apr; 110(4):766-73. PMID: 19322942.
      View in: PubMed
    10. Alkire M, Hudetz AG, Tononi G. Consciousness and anesthesia. Science. 2008 Nov 07; 322(5903):876-80. PMID: 18988836; PMCID: PMC2743249.
    11. Alkire M, Guzowski JF. Hypothesis: suppression of memory protein formation underlies anesthetic-induced amnesia. Anesthesiology. 2008 Nov; 109(5):768-70. PMID: 18946284; PMCID: PMC2699485.
    12. Alkire M, Gruver R, Miller J, McReynolds JR, Hahn EL, Cahill L. Neuroimaging analysis of an anesthetic gas that blocks human emotional memory. Proc Natl Acad Sci U S A. 2008 Feb 05; 105(5):1722-7. PMID: 18227504; PMCID: PMC2234211.
    13. Alkire M. Loss of effective connectivity during general anesthesia. Int Anesthesiol Clin. 2008; 46(3):55-73. PMID: 18617818.
      View in: PubMed
    14. Alkire M, McReynolds JR, Hahn EL, Trivedi AN. Thalamic microinjection of nicotine reverses sevoflurane-induced loss of righting reflex in the rat. Anesthesiology. 2007 Aug; 107(2):264-72. PMID: 17667571.
      View in: PubMed
    15. Alkire M, Nathan SV, McReynolds JR. Memory enhancing effect of low-dose sevoflurane does not occur in basolateral amygdala-lesioned rats. Anesthesiology. 2005 Dec; 103(6):1167-73. PMID: 16306728.
      View in: PubMed
    16. Haier RJ, Jung RE, Yeo RA, Head K, Alkire M. Structural brain variation, age, and response time. Cogn Affect Behav Neurosci. 2005 Jun; 5(2):246-51. PMID: 16180630.
      View in: PubMed
    17. Alkire M, Nathan SV. Does the amygdala mediate anesthetic-induced amnesia? Basolateral amygdala lesions block sevoflurane-induced amnesia. Anesthesiology. 2005 Apr; 102(4):754-60. PMID: 15791104.
      View in: PubMed
    18. Haier RJ, Jung RE, Yeo RA, Head K, Alkire M. The neuroanatomy of general intelligence: sex matters. Neuroimage. 2005 Mar; 25(1):320-7. PMID: 15734366.
      View in: PubMed
    19. Alkire M, Miller J. General anesthesia and the neural correlates of consciousness. Prog Brain Res. 2005; 150:229-44. PMID: 16186027.
      View in: PubMed
    20. Alkire M. Functional brain imaging: some parameters for success. Anesthesiology. 2004 Oct; 101(4):817-9. PMID: 15448512.
      View in: PubMed
    21. Haier RJ, Jung RE, Yeo RA, Head K, Alkire M. Structural brain variation and general intelligence. Neuroimage. 2004 Sep; 23(1):425-33. PMID: 15325390.
      View in: PubMed
    22. Alkire M, Gorski LA. Relative amnesic potency of five inhalational anesthetics follows the Meyer-Overton rule. Anesthesiology. 2004 Aug; 101(2):417-29. PMID: 15277925.
      View in: PubMed
    23. Alkire M, White NS, Hsieh R, Haier RJ. Dissociable brain activation responses to 5-Hz electrical pain stimulation: a high-field functional magnetic resonance imaging study. Anesthesiology. 2004 Apr; 100(4):939-46. PMID: 15087631.
      View in: PubMed
    24. White NS, Alkire M, Haier RJ. A voxel-based morphometric study of nondemented adults with Down Syndrome. Neuroimage. 2003 Sep; 20(1):393-403. PMID: 14527599.
      View in: PubMed
    25. White NS, Alkire M. Impaired thalamocortical connectivity in humans during general-anesthetic-induced unconsciousness. Neuroimage. 2003 Jun; 19(2 Pt 1):402-11. PMID: 12814589.
      View in: PubMed
    26. Cahill L, Alkire M. Epinephrine enhancement of human memory consolidation: interaction with arousal at encoding. Neurobiol Learn Mem. 2003 Mar; 79(2):194-8. PMID: 12591227.
      View in: PubMed
    27. Alkire M, Krejcie TC, Avram MJ. Anesthesia-induced alterations in plasma tracer concentrations may have relevance for brain imaging studies. Anesthesiology. 2002 Jul; 97(1):281-2; author reply 282. PMID: 12131139.
      View in: PubMed
    28. Alkire M, Vazdarjanova A, Dickinson-Anson H, White NS, Cahill L. Lesions of the basolateral amygdala complex block propofol-induced amnesia for inhibitory avoidance learning in rats. Anesthesiology. 2001 Sep; 95(3):708-15. PMID: 11575545.
      View in: PubMed
    29. Alkire M. The power of observation. Conscious Cogn. 2001 Jun; 10(2):236-40; discussion 246-58. PMID: 11414718.
      View in: PubMed
    30. Alkire M, Haier RJ, Fallon JH. Toward a unified theory of narcosis: brain imaging evidence for a thalamocortical switch as the neurophysiologic basis of anesthetic-induced unconsciousness. Conscious Cogn. 2000 Sep; 9(3):370-86. PMID: 10993665.
      View in: PubMed
    31. Alkire M, Pomfrett CJ, Haier RJ, Gianzero MV, Chan CM, Jacobsen BP, Fallon JH. Functional brain imaging during anesthesia in humans: effects of halothane on global and regional cerebral glucose metabolism. Anesthesiology. 1999 Mar; 90(3):701-9. PMID: 10078670.
      View in: PubMed
    32. Alkire M, Haier RJ, Fallon JH, Cahill L. Hippocampal, but not amygdala, activity at encoding correlates with long-term, free recall of nonemotional information. Proc Natl Acad Sci U S A. 1998 Nov 24; 95(24):14506-10. PMID: 9826730; PMCID: PMC24403.
    33. Alkire M. Quantitative EEG correlations with brain glucose metabolic rate during anesthesia in volunteers. Anesthesiology. 1998 Aug; 89(2):323-33. PMID: 9710389.
      View in: PubMed
    34. Alkire M, Haier RJ, Shah NK, Anderson CT. Positron emission tomography study of regional cerebral metabolism in humans during isoflurane anesthesia. Anesthesiology. 1997 Mar; 86(3):549-57. PMID: 9066320.
      View in: PubMed