Maria Cristina Kenney

Title(s)Professor, Ophthalmology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-7603
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    Collapse Research 
    Collapse Research Activities and Funding
    Protective Effects of Humanin on AMD Mitochondria
    NIH R01EY027363Mar 1, 2019 - Feb 28, 2022
    Role: Principal Investigator
    EXTRACELLULAR MATRIX ABNORMALITIES IN CORNEAL EDEMA
    NIH R01EY010836Aug 1, 1995 - Jul 31, 2004
    Role: Principal Investigator
    Abnormalities in Keratoconus Corneas
    NIH R01EY006807May 1, 1987 - Oct 31, 2004
    Role: Principal Investigator
    HUMAN DESCEMET'S MEMBRANE IN CORNEAL DISORDERS
    NIH R01EY006519Jul 1, 1985 - Jun 30, 1986
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A review on PLGA particles as a sustained drug-delivery system and its effect on the retina. Exp Eye Res. 2023 Oct; 235:109626. Marquina S, Ozgul M, Robertson-Brown K, Kenney MC. PMID: 37652091.
      View in: PubMed   Mentions:
    2. The role of mitochondrial genes on nuclear gene expression in neovascular age related macular degeneration: analysis of nuclear VEGF gene expression after ranibizumab treatment in cytoplasmic hybrid retinal pigment epithelial cell lines correlated with clinical evolution. Int J Retina Vitreous. 2023 Jul 25; 9(1):44. Costa RD, Thomaz Neto FJ, Moustafa MT, Atilano SR, Chwa M, Cáceres-Del-Carpi J, Mohamed MH, Kenney MC, Kuppermann BD. PMID: 37491310; PMCID: PMC10367366.
      View in: PubMed   Mentions:
    3. Using Human 'Personalized' Cybrids to Identify Drugs/Agents That Can Regulate Chronic Lymphoblastic Leukemia Mitochondrial Dysfunction. Int J Mol Sci. 2023 Jul 03; 24(13). Singh L, Atilano S, Chwa M, Singh MK, Ozgul M, Nesburn A, Kenney MC. PMID: 37446202; PMCID: PMC10341973.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Potential Therapeutic Functions of PU-91 and Quercetin in Personalized Cybrids Derived from Patients with Age-Related Macular Degeneration, Keratoconus, and Glaucoma. Antioxidants (Basel). 2023 Jun 22; 12(7). Salimiaghdam N, Singh L, Singh MK, Chwa M, Atilano S, Mohtashami Z, Nesburn A, Kuppermann BD, Kenney MC. PMID: 37507866; PMCID: PMC10375999.
      View in: PubMed   Mentions:
    5. Discovery and Validation of Novel LonP1 and Proteasome Inhibitor in IDH1-R132H Malignant Astrocytoma Models. bioRxiv. 2023 Apr 17. Douglas C, Lomeli N, Lepe J, Di K, Nandwana NK, Vu T, Pham J, Kenney MC, Das B, Bota DA. PMID: 37131786; PMCID: PMC10153114.
      View in: PubMed   Mentions:
    6. Stability Determination of Intact Humanin-G with Characterizations of Oxidation and Dimerization Patterns. Biomolecules. 2023 03 11; 13(3). Ozgul M, Nesburn AB, Nasralla N, Katz B, Taylan E, Kuppermann BD, Kenney MC. PMID: 36979450; PMCID: PMC10046509.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Hypoxia-induced transcriptional differences in African and Asian versus European diabetic cybrids. Sci Rep. 2023 03 07; 13(1):3818. Dolinko AH, Chwa M, Schneider K, Singh MK, Atilano S, Wu J, Kenney MC. PMID: 36882486; PMCID: PMC9992459.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Mitochondrial Open Reading Frame of the 12S rRNA Type-c: Potential Therapeutic Candidate in Retinal Diseases. Antioxidants (Basel). 2023 Feb 18; 12(2). Mohtashami Z, Singh MK, Neto FT, Salimiaghdam N, Hasanpour H, Kenney MC. PMID: 36830076; PMCID: PMC9952431.
      View in: PubMed   Mentions:
    9. Vitreal Concentrations of Vascular Endothelial Growth Factor in Patients with Rhegmatogenous Retinal Detachment. J Clin Med. 2023 Feb 05; 12(4). Hasanpour H, Kenney MC, Kuppermann BD, Esfahani MR, Kanavi MR, Singh MK, Soheilian M. PMID: 36835796; PMCID: PMC9961416.
      View in: PubMed   Mentions:
    10. Quantitative cone contrast threshold testing in patients with differing pathophysiological mechanisms causing retinal diseases. Int J Retina Vitreous. 2023 Feb 02; 9(1):9. White KM, Livnat I, Frambach CR, Doan J, Mehta UV, Yuh C, Palma AM, Jameson KA, Kenney MC, Mehta MC, Boisvert CJ, Crow WR, Browne AW. PMID: 36732855; PMCID: PMC9893567.
      View in: PubMed   Mentions:
    11. MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases. Int J Mol Sci. 2022 Oct 09; 23(19). Mohtashami Z, Singh MK, Salimiaghdam N, Ozgul M, Kenney MC. PMID: 36233287; PMCID: PMC9570330.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    12. Differential modulation of cancer-related genes by mitochondrial DNA haplogroups and the STING DNA sensing system. FASEB Bioadv. 2022 Oct; 4(10):675-689. Schneider K, Chwa M, Atilano SR, Nashine S, Udar N, Boyer DS, Jazwinski SM, Miceli MV, Nesburn AB, Kuppermann BD, Kenney MC. PMID: 36238361; PMCID: PMC9536090.
      View in: PubMed   Mentions:
    13. Differential Epigenetic Status and Responses to Stressors between Retinal Cybrids Cells with African versus European Mitochondrial DNA: Insights into Disease Susceptibilities. Cells. 2022 08 26; 11(17). Atilano SR, Abedi S, Ianopol NV, Singh MK, Norman JL, Malik D, Falatoonzadeh P, Chwa M, Nesburn AB, Kuppermann BD, Kenney MC. PMID: 36078063; PMCID: PMC9454894.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    14. The Transcriptome Profile of Retinal Pigment Epithelium and Müller Cell Lines Protected by Risuteganib Against Hydrogen Peroxide Stress. J Ocul Pharmacol Ther. 2022 09; 38(7):513-526. Shao Z, Chwa M, Atilano SR, Park J, Karageozian H, Karageozian V, Kenney MC. PMID: 35731128; PMCID: PMC9508878.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    15. Altered Retrograde Signaling Patterns in Breast Cancer Cells Cybrids with H and J Mitochondrial DNA Haplogroups. Int J Mol Sci. 2022 Jun 15; 23(12). Chang S, Singh L, Thaker K, Abedi S, Singh MK, Patel TH, Chwa M, Atilano SR, Udar N, Bota D, Kenney MC. PMID: 35743133; PMCID: PMC9224519.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    16. Effect of Humanin G (HNG) on inflammation in age-related macular degeneration (AMD). Aging (Albany NY). 2022 05 16; 14(10):4247-4269. Nashine S, Cohen P, Wan J, Kenney MC. PMID: 35576057; PMCID: PMC9186758.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    17. Impacts of Bacteriostatic and Bactericidal Antibiotics on the Mitochondria of the Age-Related Macular Degeneration Cybrid Cell Lines. Biomolecules. 2022 05 07; 12(5). Salimiaghdam N, Singh L, Singh MK, Chwa M, Atilano SR, Mohtashami Z, Nesburn AB, Kuppermann BD, Lu SY, Kenney MC. PMID: 35625603; PMCID: PMC9138285.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    18. Differential mitochondrial and cellular responses between H vs. J mtDNA haplogroup-containing human RPE transmitochondrial cybrid cells. Exp Eye Res. 2022 06; 219:109013. Panvini AR, Gvritishvili A, Galvan H, Nashine S, Atilano SR, Kenney MC, Tombran-Tink J. PMID: 35283109; PMCID: PMC9949352.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    19. Effects of fluoroquinolones and tetracyclines on mitochondria of human retinal MIO-M1 cells. Exp Eye Res. 2022 01; 214:108857. Salimiaghdam N, Singh L, Schneider K, Chwa M, Atilano SR, Nalbandian A, Limb GA, Kenney MC. PMID: 34856207; PMCID: PMC9949354.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    20. Differential responses of AMD mitochondrial DNA haplogroups to PU-91, a mitochondria-targeting drug. Mitochondrion. 2021 09; 60:189-200. Bao A, Nashine S, Atilano S, Chwa M, Federoff H, Kenney MC. PMID: 34400356.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    21. Mitochondrial DNA polymorphisms and biogenesis genes in primary and metastatic uveal melanoma cell lines. Cancer Genet. 2021 08; 256-257:91-99. Singh L, Atilano SR, Jager MJ, Kenney MC. PMID: 34082186.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    22. Anti-VEGF Drugs Influence Epigenetic Regulation and AMD-Specific Molecular Markers in ARPE-19 Cells. Cells. 2021 04 12; 10(4). Hamid MA, Moustafa MT, Nashine S, Costa RD, Schneider K, Atilano SR, Kuppermann BD, Kenney MC. PMID: 33921543; PMCID: PMC8069662.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    23. Age-Related Macular Degeneration (AMD) Transmitochondrial Cybrids Protected from Cellular Damage and Death by Human Retinal Progenitor Cells (hRPCs). Stem Cells Int. 2021; 2021:6655372. Yu JJ, Azzam DB, Chwa M, Schneider K, Cho JH, Hsiang C, Klassen H, Kenney MC, Yang J. PMID: 33628267; PMCID: PMC7886532.
      View in: PubMed   Mentions: 2  
    24. Low frequency mitochondrial DNA heteroplasmy SNPs in blood, retina, and [RPE+choroid] of age-related macular degeneration subjects. PLoS One. 2021; 16(1):e0246114. Atilano SR, Udar N, Satalich TA, Udar V, Chwa M, Kenney MC. PMID: 33513185; PMCID: PMC7846006.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsCTClinical Trials
    25. Mitochondria: The Retina's Achilles' Heel in AMD. Adv Exp Med Biol. 2021; 1256:237-264. Ferrington DA, Kenney MC, Atilano SR, Hurley JB, Brown EE, Ash JD. PMID: 33848005.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    26. J or H mtDNA haplogroups in retinal pigment epithelial cells: Effects on cell physiology, cargo in extracellular vesicles, and differential uptake of such vesicles by naïve recipient cells. Biochim Biophys Acta Gen Subj. 2021 04; 1865(4):129798. Nicholson C, Ishii M, Annamalai B, Chandler K, Chwa M, Kenney MC, Shah N, Rohrer B. PMID: 33217521; PMCID: PMC8396072.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    27. Prognostic significance of PD-1/PD-L1 expression in uveal melanoma: correlation with tumor-infiltrating lymphocytes and clinicopathological parameters. Cancer Immunol Immunother. 2021 May; 70(5):1291-1303. Singh L, Singh MK, Kenney MC, Jager MJ, Rizvi MA, Meel R, Lomi N, Bakhshi S, Sen S, Kashyap S. PMID: 33136179.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    28. Memantine, Simvastatin, and Epicatechin Inhibit 7-Ketocholesterol-induced Apoptosis in Retinal Pigment Epithelial Cells But Not Neurosensory Retinal Cells In Vitro. J Ophthalmic Vis Res. 2020 Oct-Dec; 15(4):470-480. Neekhra A, Tran J, Esfahani PR, Schneider K, Pham K, Sharma A, Chwa M, Luthra S, Gramajo AL, Mansoor S, Kuppermann BD, Kenney MC. PMID: 33133437; PMCID: PMC7591846.
      View in: PubMed   Mentions: 1  
    29. Differential effects of risuteganib and bevacizumab on AMD cybrid cells. Exp Eye Res. 2021 02; 203:108287. Schneider K, Chwa M, Atilano SR, Shao Z, Park J, Karageozian H, Karageozian V, Kenney MC. PMID: 33075294; PMCID: PMC9377643.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    30. Differential effects of cisplatin on cybrid cells with varying mitochondrial DNA haplogroups. PeerJ. 2020; 8:e9908. Abedi S, Yung G, Atilano SR, Thaker K, Chang S, Chwa M, Schneider K, Udar N, Bota D, Kenney MC. PMID: 33062421; PMCID: PMC7533064.
      View in: PubMed   Mentions: 6     Fields:    
    31. Potential adverse effects of ciprofloxacin and tetracycline on ARPE-19 cell lines. BMJ Open Ophthalmol. 2020; 5(1):e000458. Salimiaghdam N, Singh L, Schneider K, Nalbandian A, Chwa M, Atilano SR, Bao A, Kenney MC. PMID: 32724857; PMCID: PMC7375423.
      View in: PubMed   Mentions: 6     Fields:    
    32. Further understanding of epigenetic dysfunction of the retinal pigment epithelium in AMD. Expert Rev Ophthalmol. 2020; 15(4):221-231. Kenney MC, Nashine S. PMID: 33732291; PMCID: PMC7963213.
      View in: PubMed   Mentions:
    33. Role of Citicoline in an in vitro AMD model. Aging (Albany NY). 2020 05 29; 12(10):9031-9040. Nashine S, Kenney MC. PMID: 32470946; PMCID: PMC7288938.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    34. Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD. Cells. 2020 04 29; 9(5). Nashine S, Kenney MC. PMID: 32365540; PMCID: PMC7290668.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    35. A two-step method for identifying photopigment opsin and rhodopsin gene sequences underlying human color vision phenotypes. Mol Vis. 2020; 26:158-172. Atilano SR, Kenney MC, Briscoe AD, Jameson KA. PMID: 32180681; PMCID: PMC7058431.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    36. Role of Resveratrol in Transmitochondrial AMD RPE Cells. Nutrients. 2020 Jan 06; 12(1). Nashine S, Nesburn AB, Kuppermann BD, Kenney MC. PMID: 31935891; PMCID: PMC7019821.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    37. In vitro response and gene expression of human retinal Müller cells treated with different anti-VEGF drugs. Exp Eye Res. 2020 02; 191:107903. Cáceres-Del-Carpio J, Moustafa MT, Toledo-Corral J, Hamid MA, Atilano SR, Schneider K, Fukuhara PS, Costa RD, Norman JL, Malik D, Chwa M, Boyer DS, Limb GA, Kenney MC, Kuppermann BD. PMID: 31904361; PMCID: PMC7058176.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    38. African and Asian Mitochondrial DNA Haplogroups Confer Resistance Against Diabetic Stresses on Retinal Pigment Epithelial Cybrid Cells In Vitro. Mol Neurobiol. 2020 Mar; 57(3):1636-1655. Dolinko AH, Chwa M, Atilano SR, Kenney MC. PMID: 31811564; PMCID: PMC7123578.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    39. PU-91 drug rescues human age-related macular degeneration RPE cells; implications for AMD therapeutics. Aging (Albany NY). 2019 09 02; 11(17):6691-6713. Nashine S, Subramaniam SR, Chwa M, Nesburn A, Kuppermann BD, Federoff H, Kenney MC. PMID: 31477635; PMCID: PMC6756897.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    40. European mtDNA Variants Are Associated With Differential Responses to Cisplatin, an Anticancer Drug: Implications for Drug Resistance and Side Effects. Front Oncol. 2019; 9:640. Patel TH, Norman L, Chang S, Abedi S, Liu C, Chwa M, Atilano SR, Thaker K, Lu S, Jazwinski SM, Miceli MV, Udar N, Bota D, Kenney MC. PMID: 31380278; PMCID: PMC6659439.
      View in: PubMed   Mentions: 16  
    41. Age-related macular degeneration (AMD) mitochondria modulate epigenetic mechanisms in retinal pigment epithelial cells. Exp Eye Res. 2019 12; 189:107701. Nashine S, Nesburn AB, Kuppermann BD, Kenney MC. PMID: 31226340; PMCID: PMC7192350.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    42. Nutraceutical effects of Emblicaofficinalis in age-related macular degeneration. Aging (Albany NY). 2019 02 21; 11(4):1177-1188. Nashine S, Kanodia R, Nesburn AB, Soman G, Kuppermann BD, Kenney MC. PMID: 30792375; PMCID: PMC6402529.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    43. Corneal Oxidative Damage in Keratoconus Cells due to Decreased Oxidant Elimination from Modified Expression Levels of SOD Enzymes, PRDX6, SCARA3, CPSF3, and FOXM1. J Ophthalmic Vis Res. 2019 Jan-Mar; 14(1):62-70. Atilano SR, Lee DH, Fukuhara PS, Chwa M, Nesburn AB, Udar N, Kenney MC. PMID: 30820289; PMCID: PMC6388514.
      View in: PubMed   Mentions: 14  
    44. Effects of Brimonidine on Retinal Pigment Epithelial Cells and Müller Cells Exposed to Amyloid-Beta 1-42 Peptide In Vitro. Ophthalmic Surg Lasers Imaging Retina. 2018 10 15; 49(10):S23-S28. Tsao SW, Gabriel R, Thaker K, Kuppermann BD, Kenney MC. PMID: 30339264.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    45. Effects of Antiangiogenic Drugs on Expression Patterns of Epigenetic Pathway Genes. Ophthalmic Surg Lasers Imaging Retina. 2018 10 15; 49(10):S29-S33. Hamid MA, Moustafa MT, Càceres-Del-Carpio J, Kuppermann BD, Kenney MC. PMID: 30339265.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    46. Characterizing the protective effects of SHLP2, a mitochondrial-derived peptide, in macular degeneration. Sci Rep. 2018 10 11; 8(1):15175. Nashine S, Cohen P, Nesburn AB, Kuppermann BD, Kenney MC. PMID: 30310092; PMCID: PMC6182005.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    47. Protective Effects of 17β-Estradiol on Benzo(e) pyrene[B(e)P]-induced Toxicity in ARPE-19 cells. J Ophthalmic Vis Res. 2018 Oct-Dec; 13(4):419-425. Sapkal AU, Nashine S, Mansoor S, Sharma VR, Ramirez CA, Migon RZ, Gupta NK, Chwa M, Kuppermann BD, Kenney MC. PMID: 30479711; PMCID: PMC6210882.
      View in: PubMed   Mentions: 3  
    48. Mitochondrial Impairment in Antibiotic Induced Toxic Optic Neuropathies. Curr Eye Res. 2018 10; 43(10):1199-1204. Yu JJ, Lee DH, Gallagher SP, Kenney MC, Boisvert CJ. PMID: 30040491.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    49. Effects of bevacizumab, ranibizumab, and aflibercept on phagocytic properties in human RPE cybrids with AMD versus normal mitochondria. Exp Eye Res. 2018 12; 177:112-116. Vo TA, Abedi S, Schneider K, Chwa M, Kenney MC. PMID: 30071215; PMCID: PMC7105352.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    50. Axial mechanical and structural characterization of keratoconus corneas. Exp Eye Res. 2018 10; 175:14-19. Mikula E, Winkler M, Juhasz T, Brown DJ, Shoa G, Tran S, Kenney MC, Jester JV. PMID: 29842851; PMCID: PMC7324026.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    51. cGAS drives noncanonical-inflammasome activation in age-related macular degeneration. Nat Med. 2018 01; 24(1):50-61. Kerur N, Fukuda S, Banerjee D, Kim Y, Fu D, Apicella I, Varshney A, Yasuma R, Fowler BJ, Baghdasaryan E, Marion KM, Huang X, Yasuma T, Hirano Y, Serbulea V, Ambati M, Ambati VL, Kajiwara Y, Ambati K, Hirahara S, Bastos-Carvalho A, Ogura Y, Terasaki H, Oshika T, Kim KB, Hinton DR, Leitinger N, Cambier JC, Buxbaum JD, Kenney MC, Jazwinski SM, Nagai H, Hara I, West AP, Fitzgerald KA, Sadda SR, Gelfand BD, Ambati J. PMID: 29176737; PMCID: PMC5760363.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    52. The Role of Mitochondria in AMD: Current Knowledge and Future Applications. J Ophthalmic Vis Res. 2017 Oct-Dec; 12(4):424-428. Riazi-Esfahani M, Kuppermann BD, Kenney MC. PMID: 29090054; PMCID: PMC5644411.
      View in: PubMed   Mentions: 13  
    53. Protective Effects of Memantine on Hydroquinone-Treated Human Retinal Pigment Epithelium Cells and Human Retinal Müller Cells. J Ocul Pharmacol Ther. 2017 10; 33(8):610-619. Moustafa MT, Ramirez C, Schneider K, Atilano SR, Limb GA, Kuppermann BD, Kenney MC. PMID: 28961056.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    54. Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage. Cell Death Dis. 2017 07 20; 8(7):e2951. Nashine S, Cohen P, Chwa M, Lu S, Nesburn AB, Kuppermann BD, Kenney MC. PMID: 28726777; PMCID: PMC5550888.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCellsCTClinical Trials
    55. Effects of Benzo(e)pyrene on Reactive Oxygen/Nitrogen Species and Inflammatory Cytokines Induction in Human RPE Cells and Attenuation by Mitochondrial-involved Mechanism. J Ophthalmic Vis Res. 2016 Oct-Dec; 11(4):385-393. Estrago-Franco MF, Moustafa MT, Riazi-Esfahani M, Sapkal AU, Piche-Lopez R, Patil AJ, Sharma A, Falatoonzadeh P, Chwa M, Luczy-Bachman G, Kuppermann BD, Kenney MC. PMID: 27994808; PMCID: PMC5139551.
      View in: PubMed   Mentions: 3  
    56. Differential Expression of Complement Markers in Normal and AMD Transmitochondrial Cybrids. PLoS One. 2016; 11(8):e0159828. Nashine S, Chwa M, Kazemian M, Thaker K, Lu S, Nesburn A, Kuppermann BD, Kenney MC. PMID: 27486856; PMCID: PMC4972370.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    57. Increased expression of ApoE and protection from amyloid-beta toxicity in transmitochondrial cybrids with haplogroup K mtDNA. Neurobiol Dis. 2016 09; 93:64-77. Thaker K, Chwa M, Atilano SR, Coskun P, Cáceres-Del-Carpio J, Udar N, Boyer DS, Jazwinski SM, Miceli MV, Nesburn AB, Kuppermann BD, Kenney MC. PMID: 27109188; PMCID: PMC5922440.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    58. Increased retinal mtDNA damage in the CFH variant associated with age-related macular degeneration. Exp Eye Res. 2016 04; 145:269-277. Ferrington DA, Kapphahn RJ, Leary MM, Atilano SR, Terluk MR, Karunadharma P, Chen GK, Ratnapriya R, Swaroop A, Montezuma SR, Kenney MC. PMID: 26854823; PMCID: PMC4842097.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    59. Brimonidine Can Prevent In Vitro Hydroquinone Damage on Retinal Pigment Epithelium Cells and Retinal Müller Cells. J Ocul Pharmacol Ther. 2016 Mar; 32(2):102-8. Ramírez C, Cáceres-del-Carpio J, Chu J, Chu J, Moustafa MT, Chwa M, Limb GA, Kuppermann BD, Kenney MC. PMID: 26624556; PMCID: PMC6445176.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    60. Effects of light on retinal pigment epithelial cells, neurosensory retinal cells and Müller cells treated with Brilliant Blue G. Clin Exp Ophthalmol. 2015 Dec; 43(9):820-9. Mansoor S, Sharma A, Cáceres-Del-Carpio J, Zacharias LC, Patil AJ, Gupta N, Limb GA, Kenney MC, Kuppermann BD. PMID: 26126999.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    61. Mitochondrial DNA variants can mediate methylation status of inflammation, angiogenesis and signaling genes. Hum Mol Genet. 2015 Aug 15; 24(16):4491-503. Atilano SR, Malik D, Chwa M, Cáceres-Del-Carpio J, Nesburn AB, Boyer DS, Kuppermann BD, Jazwinski SM, Miceli MV, Wallace DC, Udar N, Kenney MC. PMID: 25964427; PMCID: PMC4512622.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    62. In vitro studies in VCP-associated multisystem proteinopathy suggest altered mitochondrial bioenergetics. Mitochondrion. 2015 May; 22:1-8. Nalbandian A, Llewellyn KJ, Gomez A, Walker N, Su H, Dunnigan A, Chwa M, Vesa J, Kenney MC, Kimonis VE. PMID: 25724235; PMCID: PMC7105354.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    63. Steroid differentiation: the safety profile of various steroids on retinal cells in vitro and their implications for clinical use (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc. 2014 Jul; 112:116-41. Kuppermann BD, Zacharias LC, Kenney MC. PMID: 25646032; PMCID: PMC4311675.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    64. Human retinal transmitochondrial cybrids with J or H mtDNA haplogroups respond differently to ultraviolet radiation: implications for retinal diseases. PLoS One. 2014; 9(2):e99003. Malik D, Hsu T, Falatoonzadeh P, Cáceres-del-Carpio J, Tarek M, Chwa M, Atilano SR, Ramirez C, Nesburn AB, Boyer DS, Kuppermann BD, Jazwinski SM, Miceli MV, Wallace DC, Udar N, Kenney MC. PMID: 24919117; PMCID: PMC4053329.
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    65. Safety profiles of anti-VEGF drugs: bevacizumab, ranibizumab, aflibercept and ziv-aflibercept on human retinal pigment epithelium cells in culture. Br J Ophthalmol. 2014 Jun; 98 Suppl 1:i11-16. Malik D, Tarek M, Caceres del Carpio J, Ramirez C, Boyer D, Kenney MC, Kuppermann BD. PMID: 24836865; PMCID: PMC4033208.
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    66. Effects of triamcinolone acetonide on human trabecular meshwork cells in vitro. Indian J Ophthalmol. 2014 Apr; 62(4):429-36. Sharma A, Patil AJ, Gupta N, Estrago-Franco MF, Mansoor S, Raymond V, Kenney MC, Kuppermann BD. PMID: 24817746; PMCID: PMC4064217.
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    67. Inherited mitochondrial DNA variants can affect complement, inflammation and apoptosis pathways: insights into mitochondrial-nuclear interactions. Hum Mol Genet. 2014 Jul 01; 23(13):3537-51. Kenney MC, Chwa M, Atilano SR, Falatoonzadeh P, Ramirez C, Malik D, Tarek M, Cáceres-del-Carpio J, Nesburn AB, Boyer DS, Kuppermann BD, Vawter M, Jazwinski SM, Miceli M, Wallace DC, Udar N. PMID: 24584571; PMCID: PMC4049308.
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    68. 2-ethylpyridine, a cigarette smoke component, causes mitochondrial damage in human retinal pigment epithelial cells in vitro. Indian J Ophthalmol. 2014 Jan; 62(1):16-22. Mansoor S, Gupta N, Falatoonzadeh P, Kuppermann BD, Kenney MC. PMID: 24492497; PMCID: PMC3955065.
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    69. Effect of bevacizumab (Avastin (TM) ) on mitochondrial function of in vitro retinal pigment epithelial, neurosensory retinal and microvascular endothelial cells. Indian J Ophthalmol. 2013 Dec; 61(12):705-10. Luthra S, Sharma A, Dong J, Neekhra A, Gramajo AL, Seigel GM, Kenney MC, Kuppermann BD. PMID: 24413824; PMCID: PMC3917387.
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    70. Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: implications for population susceptibility to diseases. Biochim Biophys Acta. 2014 Feb; 1842(2):208-19. Kenney MC, Chwa M, Atilano SR, Falatoonzadeh P, Ramirez C, Malik D, Tarek M, Del Carpio JC, Nesburn AB, Boyer DS, Kuppermann BD, Vawter MP, Jazwinski SM, Miceli MV, Wallace DC, Udar N. PMID: 24200652; PMCID: PMC4326177.
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    71. In vitro evidence for mycophenolic acid dose-related cytotoxicity in human retinal cells. Retina. 2013 Nov-Dec; 33(10):2155-61. Zacharias LC, Damico FM, Kenney MC, Gasparin F, Acquesta FB, Ventura DF, Takahashi WY, Kuppermann BD. PMID: 23615344.
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    72. Hydroquinone induces oxidative and mitochondrial damage to human retinal Müller cells (MIO-M1). Neurotoxicology. 2013 Dec; 39:102-8. Ramírez C, Pham K, Franco MF, Chwa M, Limb A, Kuppermann BD, Kenney MC. PMID: 23994029.
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    73. Effects of dexamethasone on human trabecular meshwork cells in vitro. Graefes Arch Clin Exp Ophthalmol. 2013 Jul; 251(7):1741-6. Sharma A, Patil AJ, Mansoor S, Estrago-Franco MF, Raymond V, Kenney MC, Kuppermann BD. PMID: 23640538.
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    74. Mitochondrial DNA variants mediate energy production and expression levels for CFH, C3 and EFEMP1 genes: implications for age-related macular degeneration. PLoS One. 2013; 8(1):e54339. Kenney MC, Chwa M, Atilano SR, Pavlis JM, Falatoonzadeh P, Ramirez C, Malik D, Hsu T, Woo G, Soe K, Nesburn AB, Boyer DS, Kuppermann BD, Jazwinski SM, Miceli MV, Wallace DC, Udar N. PMID: 23365660; PMCID: PMC3554762.
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    75. Mitochondrial DNA haplogroups confer differences in risk for age-related macular degeneration: a case control study. BMC Med Genet. 2013 Jan 09; 14:4. Kenney MC, Hertzog D, Chak G, Atilano SR, Khatibi N, Soe K, Nobe A, Yang E, Chwa M, Zhu F, Memarzadeh M, King J, Langberg J, Small K, Nesburn AB, Boyer DS, Udar N. PMID: 23302509; PMCID: PMC3566905.
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    76. Protective effects of lipoic acid on chrysene-induced toxicity on Müller cells in vitro. Mol Vis. 2013; 19:25-38. Mansoor S, Gupta N, Luczy-Bachman G, Limb GA, Kuppermann BD, Kenney MC. PMID: 23335848; PMCID: PMC3541045.
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    77. Use of intraocular human recombinant tissue plasminogen activator as an adjunct treatment of posterior synechiae in patients with uveitis. Retin Cases Brief Rep. 2012; 6(3):290-3. Lerner LE, Patil AJ, Kenney MC, Minckler D. PMID: 25389735.
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    78. Evaluation of the toxicity of triamcinolone acetonide and dexamethasone sodium phosphate on human lens epithelial cells (HLE B-3). J Ocul Pharmacol Ther. 2011 Jun; 27(3):265-71. Sharma A, Pirouzmanesh A, Patil J, Estrago-Franco MF, Zacharias LC, Pirouzmanesh A, Andley UP, Kenney MC, Kuppermann BD. PMID: 21574867.
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    79. The effects of commercially available preservative-free FDA-approved triamcinolone (Triesence®) on retinal cells in culture. J Ocul Pharmacol Ther. 2011 Apr; 27(2):143-50. Zacharias LC, Estrago-Franco MF, Ramirez C, Kenney MC, Takahashi WY, Seigel GM, Kuppermann BD. PMID: 21500984.
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    80. Characterization of retinal and blood mitochondrial DNA from age-related macular degeneration patients. Invest Ophthalmol Vis Sci. 2010 Aug; 51(8):4289-97. Kenney MC, Atilano SR, Boyer D, Chwa M, Chak G, Chinichian S, Coskun P, Wallace DC, Nesburn AB, Udar NS. PMID: 20357205.
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    81. Protective effects of memantine and epicatechin on catechol-induced toxicity on Müller cells in vitro. Toxicology. 2010 May 27; 271(3):107-14. Mansoor S, Gupta N, Luczy-Bachman G, Limb GA, Kuppermann BD, Kenney MC. PMID: 20347921.
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    82. Valganciclovir in the treatment of cytomegalovirus retinitis in HIV-infected patients. Clin Ophthalmol. 2010 Mar 04; 4:111-9. Patil AJ, Sharma A, Kenney MC, Kuppermann BD. PMID: 20234777; PMCID: PMC2835533.
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    83. Inhibition of apoptosis in human retinal pigment epithelial cells treated with benzo(e)pyrene, a toxic component of cigarette smoke. Invest Ophthalmol Vis Sci. 2010 May; 51(5):2601-7. Mansoor S, Gupta N, Patil AJ, Estrago-Franco MF, Ramirez C, Migon R, Sapkal A, Kuppermann BD, Kenney MC. PMID: 19959636.
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    84. Mitochondrial DNA damage induced by 7-ketocholesterol in human retinal pigment epithelial cells in vitro. Invest Ophthalmol Vis Sci. 2010 Feb; 51(2):1164-70. Gramajo AL, Zacharias LC, Neekhra A, Luthra S, Atilano SR, Chwa M, Brown DJ, Kuppermann BD, Kenney MC. PMID: 19834037.
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    85. SOD1 haplotypes in familial keratoconus. Cornea. 2009 Sep; 28(8):902-7. Udar N, Atilano SR, Small K, Nesburn AB, Kenney MC. PMID: 19654524.
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    86. Effects of benzo(e)pyrene on the retinal neurosensory cells and human microvascular endothelial cells in vitro. Curr Eye Res. 2009 Aug; 34(8):672-82. Patil AJ, Gramajo AL, Sharma A, Chwa M, Seigel GM, Kuppermann BD, Kenney MC. PMID: 19899995.
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    87. Hydrogen peroxide causes mitochondrial DNA damage in corneal epithelial cells. Cornea. 2009 May; 28(4):426-33. Atilano SR, Chwa M, Kim DW, Jordan N, Udar N, Coskun P, Jester JV, Wallace DC, Kenney MC. PMID: 19411962.
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    88. Differential effects of nicotine on retinal and vascular cells in vitro. Toxicology. 2009 May 02; 259(1-2):69-76. Patil AJ, Gramajo AL, Sharma A, Seigel GM, Kuppermann BD, Kenney MC. PMID: 19428945.
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    89. Intraocular sustained-release delivery systems for triamcinolone acetonide. Pharm Res. 2009 Apr; 26(4):770-84. Mansoor S, Kuppermann BD, Kenney MC. PMID: 19184374.
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    90. Mitochondrial DNA haplogroups associated with age-related macular degeneration. Invest Ophthalmol Vis Sci. 2009 Jun; 50(6):2966-74. Udar N, Atilano SR, Memarzadeh M, Boyer DS, Chwa M, Lu S, Maguen B, Langberg J, Coskun P, Wallace DC, Nesburn AB, Khatibi N, Hertzog D, Le K, Hwang D, Kenney MC. PMID: 19151382.
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    91. Effects of Benzo(e)Pyrene, a toxic component of cigarette smoke, on human retinal pigment epithelial cells in vitro. Invest Ophthalmol Vis Sci. 2008 Nov; 49(11):5111-7. Sharma A, Neekhra A, Gramajo AL, Patil J, Chwa M, Kuppermann BD, Kenney MC. PMID: 18586875.
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    92. Hypersensitive response to oxidative stress in keratoconus corneal fibroblasts. Invest Ophthalmol Vis Sci. 2008 Oct; 49(10):4361-9. Chwa M, Atilano SR, Hertzog D, Zheng H, Langberg J, Kim DW, Kenney MC. PMID: 18515575.
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    93. Use of intravitreal triamcinolone in the treatment of macular edema related to retinal vein occlusion. Open Ophthalmol J. 2008 Apr 07; 2:68-72. Sharma A, D Kuppermann B, Kenney MC. PMID: 19517029; PMCID: PMC2694595.
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    94. 7-Ketocholesterol activates caspases-3/7, -8, and -12 in human microvascular endothelial cells in vitro. Microvasc Res. 2008 Apr; 75(3):343-50. Luthra S, Dong J, Gramajo AL, Chwa M, Kim DW, Neekhra A, Kuppermann BD, Kenney MC. PMID: 18068200.
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    95. Compositional differences between infant and adult human corneal basement membranes. Invest Ophthalmol Vis Sci. 2007 Nov; 48(11):4989-99. Kabosova A, Azar DT, Bannikov GA, Campbell KP, Durbeej M, Ghohestani RF, Jones JC, Kenney MC, Koch M, Ninomiya Y, Patton BL, Paulsson M, Sado Y, Sage EH, Sasaki T, Sorokin LM, Steiner-Champliaud MF, Sun TT, Sundarraj N, Timpl R, Virtanen I, Ljubimov AV. PMID: 17962449; PMCID: PMC2151758.
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    96. Caspase-8, -12, and -3 activation by 7-ketocholesterol in retinal neurosensory cells. Invest Ophthalmol Vis Sci. 2007 Mar; 48(3):1362-7. Neekhra A, Luthra S, Chwa M, Seigel G, Gramajo AL, Kuppermann BD, Kenney MC. PMID: 17325185.
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    97. Second-harmonic imaging microscopy of normal human and keratoconus cornea. Invest Ophthalmol Vis Sci. 2007 Mar; 48(3):1087-94. Morishige N, Wahlert AJ, Kenney MC, Brown DJ, Kawamoto K, Chikama T, Nishida T, Jester JV. PMID: 17325150; PMCID: PMC1894888.
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    98. Complement factor H polymorphism in age-related macular degeneration. Ophthalmology. 2007 Jul; 114(7):1327-31. Narayanan R, Butani V, Boyer DS, Atilano SR, Resende GP, Kim DS, Chakrabarti S, Kuppermann BD, Khatibi N, Chwa M, Nesburn AB, Kenney MC. PMID: 17306880.
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    99. Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2006 Dec; 47(12):5569-75. Luthra S, Fardin B, Dong J, Hertzog D, Kamjoo S, Gebremariam S, Butani V, Narayanan R, Mungcal JK, Kuppermann BD, Kenney MC. PMID: 17122150.
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    100. Pseudophakic corneal edema: A review of mechanisms and treatments. Cornea. 2006 Oct; 25(9):993-1004. Narayanan R, Gaster RN, Kenney MC. PMID: 17133043.
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    101. SOD1: a candidate gene for keratoconus. Invest Ophthalmol Vis Sci. 2006 Aug; 47(8):3345-51. Udar N, Atilano SR, Brown DJ, Holguin B, Small K, Nesburn AB, Kenney MC. PMID: 16877401.
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    102. Increased stress-induced generation of reactive oxygen species and apoptosis in human keratoconus fibroblasts. Invest Ophthalmol Vis Sci. 2006 May; 47(5):1902-10. Chwa M, Atilano SR, Reddy V, Jordan N, Kim DW, Kenney MC. PMID: 16638997.
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    103. Evaluation of in vitro effects of bevacizumab (Avastin) on retinal pigment epithelial, neurosensory retinal, and microvascular endothelial cells. Retina. 2006 May-Jun; 26(5):512-8. Luthra S, Narayanan R, Marques LE, Chwa M, Kim DW, Dong J, Seigel GM, Neekhra A, Gramajo AL, Brown DJ, Kenney MC, Kuppermann BD. PMID: 16770256.
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    104. Toxicity of triamcinolone acetonide on retinal neurosensory and pigment epithelial cells. Invest Ophthalmol Vis Sci. 2006 Feb; 47(2):722-8. Narayanan R, Mungcal JK, Kenney MC, Seigel GM, Kuppermann BD. PMID: 16431973.
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    105. Toxicity of indocyanine green (ICG) in combination with light on retinal pigment epithelial cells and neurosensory retinal cells. Curr Eye Res. 2005 Jun; 30(6):471-8. Narayanan R, Kenney MC, Kamjoo S, Trinh TH, Seigel GM, Resende GP, Kuppermann BD. PMID: 16020280.
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    106. Accumulation of mitochondrial DNA damage in keratoconus corneas. Invest Ophthalmol Vis Sci. 2005 Apr; 46(4):1256-63. Atilano SR, Coskun P, Chwa M, Jordan N, Reddy V, Le K, Wallace DC, Kenney MC. PMID: 15790887.
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    107. Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder. Invest Ophthalmol Vis Sci. 2005 Mar; 46(3):823-32. Kenney MC, Chwa M, Atilano SR, Tran A, Carballo M, Saghizadeh M, Vasiliou V, Adachi W, Brown DJ. PMID: 15728537.
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    108. Trypan blue: effect on retinal pigment epithelial and neurosensory retinal cells. Invest Ophthalmol Vis Sci. 2005 Jan; 46(1):304-9. Narayanan R, Kenney MC, Kamjoo S, Trinh TH, Seigel GM, Resende GP, Kuppermann BD. PMID: 15623789.
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    109. Altered expression of aquaporins in bullous keratopathy and Fuchs' dystrophy corneas. J Histochem Cytochem. 2004 Oct; 52(10):1341-50. Kenney MC, Atilano SR, Zorapapel N, Holguin B, Gaster RN, Ljubimov AV. PMID: 15385580.
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    110. Elements of the nitric oxide pathway can degrade TIMP-1 and increase gelatinase activity. Mol Vis. 2004 Apr 16; 10:281-8. Brown DJ, Lin B, Chwa M, Atilano SR, Kim DW, Kenney MC. PMID: 15105792.
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    111. Keratoconus--no association with the transforming growth factor beta-induced gene in a cohort of American patients. Cornea. 2004 Jan; 23(1):13-7. Udar N, Kenney MC, Chalukya M, Anderson T, Morales L, Brown D, Nesburn A, Small K. PMID: 14701952.
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    112. Insulin-like growth factor-I (IGF-I) and transforming growth factor-beta (TGF-beta) modulate tenascin-C and fibrillin-1 in bullous keratopathy stromal cells in vitro. Exp Eye Res. 2003 Nov; 77(5):537-46. Kenney MC, Zorapapel N, Atilano S, Chwa M, Ljubimov A, Brown D. PMID: 14550395.
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    113. The cascade hypothesis of keratoconus. Cont Lens Anterior Eye. 2003 Sep; 26(3):139-46. Cristina Kenney M, Brown DJ. PMID: 16303509.
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    114. Oxysterol-induced toxicity in R28 and ARPE-19 cells. Neurochem Res. 2003 Jun; 28(6):883-91. Ong JM, Aoki AM, Seigel GM, Sacerio I, Castellon R, Nesburn AB, Kenney MC. PMID: 12718442.
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    115. Evaluation of techniques using amplified nucleic acid probes for gene expression profiling. Biomol Eng. 2003 Mar; 20(3):97-106. Saghizadeh M, Brown DJ, Tajbakhsh J, Chen Z, Kenney MC, Farber DB, Nelson SF. PMID: 12684071.
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    116. Effects of tenascin-C on normal and diabetic retinal endothelial cells in culture. Invest Ophthalmol Vis Sci. 2002 Aug; 43(8):2758-66. Castellon R, Caballero S, Hamdi HK, Atilano SR, Aoki AM, Tarnuzzer RW, Kenney MC, Grant MB, Ljubimov AV. PMID: 12147613.
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    117. Alu DNA polymorphism in ACE gene is protective for age-related macular degeneration. Biochem Biophys Res Commun. 2002 Jul 19; 295(3):668-72. Hamdi HK, Reznik J, Castellon R, Atilano SR, Ong JM, Udar N, Tavis JH, Aoki AM, Nesburn AB, Boyer DS, Small KW, Brown DJ, Kenney MC. PMID: 12099691.
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    118. Effects of angiogenic growth factor combinations on retinal endothelial cells. Exp Eye Res. 2002 Apr; 74(4):523-35. Castellon R, Hamdi HK, Sacerio I, Aoki AM, Kenney MC, Ljubimov AV. PMID: 12076096.
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    119. Extracellular matrix and matrix metalloproteinase changes in human corneas after complicated laser-assisted in situ keratomileusis (LASIK). Cornea. 2002 Jan; 21(1):95-100. Maguen E, Zorapapel NC, Zieske JD, Ninomiya Y, Sado Y, Kenney MC, Ljubimov AV. PMID: 11805516.
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    120. Extracellular matrix and Na+,K+-ATPase in human corneas following cataract surgery: comparison with bullous keratopathy and Fuchs' dystrophy corneas. Cornea. 2002 Jan; 21(1):74-80. Ljubimov AV, Atilano SR, Garner MH, Maguen E, Nesburn AB, Kenney MC. PMID: 11805512.
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    121. Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas. J Histochem Cytochem. 2001 Nov; 49(11):1341-50. Ljubimov AV, Saghizadeh M, Pytela R, Sheppard D, Kenney MC. PMID: 11668187.
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    122. Altered expression of growth factors and cytokines in keratoconus, bullous keratopathy and diabetic human corneas. Exp Eye Res. 2001 Aug; 73(2):179-89. Saghizadeh M, Chwa M, Aoki A, Lin B, Pirouzmanesh A, Brown DJ, Ljubimov AV, Kenney MC. PMID: 11446768.
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    123. Effects of cholesterol and apolipoprotein E on retinal abnormalities in ApoE-deficient mice. Invest Ophthalmol Vis Sci. 2001 Jul; 42(8):1891-900. Ong JM, Zorapapel NC, Rich KA, Wagstaff RE, Lambert RW, Rosenberg SE, Moghaddas F, Pirouzmanesh A, Aoki AM, Kenney MC. PMID: 11431458.
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    124. Identification of cell types in human diseased corneas. Cornea. 2001 Apr; 20(3):309-16. Kenney MC, Chwa M, Lin B, Huang GH, Ljubimov AV, Brown DJ. PMID: 11322422.
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    125. Overexpression of matrix metalloproteinase-10 and matrix metalloproteinase-3 in human diabetic corneas: a possible mechanism of basement membrane and integrin alterations. Am J Pathol. 2001 Feb; 158(2):723-34. Saghizadeh M, Brown DJ, Castellon R, Chwa M, Huang GH, Ljubimova JY, Rosenberg S, Spirin KS, Stolitenko RB, Adachi W, Kinoshita S, Murphy G, Windsor LJ, Kenney MC, Ljubimov AV. PMID: 11159210; PMCID: PMC1850323.
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    126. Everett Kinsey lecture. The elusive causes of keratoconus: a working hypothesis. CLAO J. 2000 Jan; 26(1):10-3. Kenney MC, Brown DJ, Rajeev B. PMID: 10656302.
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    127. Analysis of gene expression in human bullous keratopathy corneas containing limiting amounts of RNA. Invest Ophthalmol Vis Sci. 1999 Dec; 40(13):3108-15. Spirin KS, Ljubimov AV, Castellon R, Wiedoeft O, Marano M, Sheppard D, Kenney MC, Brown DJ. PMID: 10586931.
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    128. Basement membrane and growth factor gene expression in normal and diabetic human retinas. Curr Eye Res. 1999 Jun; 18(6):490-9. Spirin KS, Saghizadeh M, Lewin SL, Zardi L, Kenney MC, Ljubimov AV. PMID: 10435836.
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    129. Enhanced expression of a transmembrane phosphotyrosine phosphatase (LAR) in keratoconus cultures and corneas. Exp Eye Res. 1999 Mar; 68(3):283-93. Chiplunkar S, Chamblis K, Chwa M, Rosenberg S, Kenney MC, Brown DJ. PMID: 10079136.
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    130. Human corneal epithelial basement membrane and integrin alterations in diabetes and diabetic retinopathy. J Histochem Cytochem. 1998 Sep; 46(9):1033-41. Ljubimov AV, Huang ZS, Huang GH, Burgeson RE, Gullberg D, Miner JH, Ninomiya Y, Sado Y, Kenney MC. PMID: 9705969.
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    131. Extracellular matrix changes in human corneas after radial keratotomy. Exp Eye Res. 1998 Sep; 67(3):265-72. Ljubimov AV, Alba SA, Burgeson RE, Ninomiya Y, Sado Y, Sun TT, Nesburn AB, Kenney MC, Maguen E. PMID: 9778407.
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    132. Expression of tenascin-C splice variants in normal and bullous keratopathy human corneas. Invest Ophthalmol Vis Sci. 1998 Jun; 39(7):1135-42. Ljubimov AV, Saghizadeh M, Spirin KS, Khin HL, Lewin SL, Zardi L, Bourdon MA, Kenney MC. PMID: 9620072.
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    133. Increased expression of fibrillin-1 in human corneas with bullous keratopathy. Cornea. 1998 May; 17(3):309-14. Ljubimov AV, Saghizadeh M, Spirin KS, Mecham RP, Sakai LY, Kenney MC. PMID: 9603388.
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    134. Novel splice variants of human tenascin-C mRNA identified in normal and bullous keratopathy corneas. Cornea. 1998 May; 17(3):326-32. Saghizadeh M, Khin HL, Bourdon MA, Kenney MC, Ljubimov AV. PMID: 9603390.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    135. Localization of TIMP-1, TIMP-2, TIMP-3, gelatinase A and gelatinase B in pathological human corneas. Curr Eye Res. 1998 Mar; 17(3):238-46. Kenney MC, Chwa M, Alba A, Saghizadeh M, Huang ZS, Brown DJ. PMID: 9543631.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    136. Alterations of corneal extracellular matrix after multiple refractive procedures: a clinical and immunohistochemical study. Cornea. 1997 Nov; 16(6):675-82. Maguen E, Alba SA, Burgeson RE, Butkowski RJ, Michael AF, Kenney MC, Nesburn AB, Ljubimov AV. PMID: 9395878.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    137. Abnormalities of the extracellular matrix in keratoconus corneas. Cornea. 1997 May; 16(3):345-51. Kenney MC, Nesburn AB, Burgeson RE, Butkowski RJ, Ljubimov AV. PMID: 9143810.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    138. Basement membrane abnormalities in human eyes with diabetic retinopathy. J Histochem Cytochem. 1996 Dec; 44(12):1469-79. Ljubimov AV, Burgeson RE, Butkowski RJ, Couchman JR, Zardi L, Ninomiya Y, Sado Y, Huang ZS, Nesburn AB, Kenney MC. PMID: 8985139.
      View in: PubMed   Mentions: 57     Fields:    Translation:Humans
    139. Cleavage of human corneal type VI collagen alpha 3 chain by matrix metalloproteinase-2. Cornea. 1996 Sep; 15(5):490-6. Myint E, Brown DJ, Ljubimov AV, Kyaw M, Kenney MC. PMID: 8862926.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    140. Altered type VI collagen synthesis by keratoconus keratocytes in vitro. Biochem Biophys Res Commun. 1996 Jul 25; 224(3):760-4. Chwa M, Kenney MC, Khin H, Brown DJ. PMID: 8713119.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    141. Extracellular matrix alterations in human corneas with bullous keratopathy. Invest Ophthalmol Vis Sci. 1996 May; 37(6):997-1007. Ljubimov AV, Burgeson RE, Butkowski RJ, Couchman JR, Wu RR, Ninomiya Y, Sado Y, Maguen E, Nesburn AB, Kenney MC. PMID: 8631643.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    142. Cleavage of structural components of mammalian vitreous by endogenous matrix metalloproteinase-2. Curr Eye Res. 1996 Apr; 15(4):439-45. Brown DJ, Bishop P, Hamdi H, Kenney MC. PMID: 8717491.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    143. Human corneal basement membrane heterogeneity: topographical differences in the expression of type IV collagen and laminin isoforms. Lab Invest. 1995 Apr; 72(4):461-73. Ljubimov AV, Burgeson RE, Butkowski RJ, Michael AF, Sun TT, Kenney MC. PMID: 7723285.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    144. Characterization of an endogenous metalloproteinase in human vitreous. Curr Eye Res. 1994 Sep; 13(9):639-47. Brown D, Hamdi H, Bahri S, Kenney MC. PMID: 7805394.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    145. Increased gelatinolytic activity in keratoconus keratocyte cultures. A correlation to an altered matrix metalloproteinase-2/tissue inhibitor of metalloproteinase ratio. Cornea. 1994 Mar; 13(2):114-24. Kenney MC, Chwa M, Opbroek AJ, Brown DJ. PMID: 8156782.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    146. Altered gelatinolytic activities in an apparent unilateral keratoconus patient. A case report. Cornea. 1994 Mar; 13(2):108-13. Brown DJ, Chwa M, Opbroek AJ, Kenney MC. PMID: 8156781.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    147. Characterization of a human corneal metalloproteinase inhibitor (TIMP-1). Curr Eye Res. 1993 Oct; 12(10):877-83. Opbroek A, Kenney MC, Brown D. PMID: 7507419.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    148. Keratoconus corneas: increased gelatinolytic activity appears after modification of inhibitors. Curr Eye Res. 1993 Jun; 12(6):571-81. Brown D, Chwa MM, Opbroek A, Kenney MC. PMID: 8359032.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    149. Characterization of the major matrix degrading metalloproteinase of human corneal stroma. Evidence for an enzyme/inhibitor complex. Exp Eye Res. 1991 Jan; 52(1):5-16. Brown D, Chwa M, Escobar M, Kenney MC. PMID: 1868885.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    150. Abnormal extracellular matrix in corneas with pseudophakic bullous keratopathy. Cornea. 1990 Apr; 9(2):115-21. Kenney MC, Chwa M. PMID: 2328580.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    151. Altered gelatinolytic activity by keratoconus corneal cells. Biochem Biophys Res Commun. 1989 May 30; 161(1):353-7. Kenney MC, Chwa M, Escobar M, Brown D. PMID: 2471530.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    152. Characterization of stroma from Fuchs' endothelial dystrophy corneas. Cornea. 1989; 8(2):90-7. Calandra A, Chwa M, Kenney MC. PMID: 2785446.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    153. High resolution 2-dimensional mapping of protease activities. Appl Theor Electrophor. 1989; 1(3):145-6. Brown D, Kenney MC. PMID: 2488596.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    154. Keratoconus: I. Biochemical studies. Exp Eye Res. 1988 Jun; 46(6):953-63. Critchfield JW, Calandra AJ, Nesburn AB, Kenney MC. PMID: 3197764.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    155. Characterization of the Descemet's membrane/posterior collagenous layer isolated from Fuchs' endothelial dystrophy corneas. Exp Eye Res. 1984 Sep; 39(3):267-77. Kenney MC, Labermeier U, Hinds D, Waring GO. PMID: 6389163.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    156. A new technique for isolation of Descemet's membrane: preliminary studies. Invest Ophthalmol Vis Sci. 1979 May; 18(5):527-32. Kenney MC, Benya PD, Nimni ME, Smith RE. PMID: 374307.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
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