Kenneth J Longmuir

Title(s)Professor Emeritus, Physiology and Biophysics
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-5865
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    Collapse Research 
    Collapse Research Activities and Funding
    Bioengineering for In Vivo-Viral Gene Delivery
    NIH R01EB003075Sep 15, 2003 - Jul 31, 2009
    Role: Principal Investigator
    STERIC-STABILIZED LIPOSOMES FOR SYSTEMIC GENE DELIVERY
    NIH R21DK058781Feb 15, 2001 - Dec 31, 2003
    Role: Principal Investigator
    ENDOCYTOSIS AND METABOLISM OF LIPOSOMES
    NIH R01GM040346Jul 1, 1988 - Jun 30, 1992
    Role: Principal Investigator
    CONTROL OF FATTY ACID METABOLISM IN LUNG TYPE II CELLS
    NIH R01HL034624Sep 30, 1985 - Jun 30, 1989
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Development, differentiation, and vascular components of subcutaneous and intrahepatic Hepa129 tumors in a mouse model of hepatocellular carcinoma. Histol Histopathol. 2016 Apr; 31(4):403-13. Robertson RT, Gutierrez PM, Baratta JL, Thordarson K, Braslow J, Haynes SM, Longmuir KJ. PMID: 26549274.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    2. Use of labeled tomato lectin for imaging vasculature structures. Histochem Cell Biol. 2015 Feb; 143(2):225-34. Robertson RT, Levine ST, Haynes SM, Gutierrez P, Baratta JL, Tan Z, Longmuir KJ. PMID: 25534591.
      View in: PubMed   Mentions: 91     Fields:    Translation:Animals
    3. Interactive computer-assisted instruction in acid-base physiology for mobile computer platforms. Adv Physiol Educ. 2014 Mar; 38(1):34-41. Longmuir KJ. PMID: 24585467.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    4. Characterization of Kupffer cells in livers of developing mice. Comp Hepatol. 2011 Jul 12; 10(1):2. Lopez BG, Tsai MS, Baratta JL, Longmuir KJ, Robertson RT. PMID: 21749715; PMCID: PMC3148529.
      View in: PubMed   Mentions: 32  
    5. Binding patterns of peptide-containing liposomes in liver and spleen of developing mice: comparison with heparan sulfate immunoreactivity. J Drug Target. 2011 Aug; 19(7):506-15. Tsai MS, Baratta JL, Longmuir KJ, Robertson RT. PMID: 20735178.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    6. Liposomal delivery of doxorubicin to hepatocytes in vivo by targeting heparan sulfate. Int J Pharm. 2009 Dec 01; 382(1-2):222-33. Longmuir KJ, Haynes SM, Baratta JL, Kasabwalla N, Robertson RT. PMID: 19664697; PMCID: PMC2784200.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    7. Cellular organization of normal mouse liver: a histological, quantitative immunocytochemical, and fine structural analysis. Histochem Cell Biol. 2009 Jun; 131(6):713-26. Baratta JL, Ngo A, Lopez B, Kasabwalla N, Longmuir KJ, Robertson RT. PMID: 19255771; PMCID: PMC2761764.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    8. Liposomes incorporating a Plasmodium amino acid sequence target heparan sulfate binding sites in liver. J Pharm Sci. 2008 Aug; 97(8):3257-73. Robertson RT, Baratta JL, Haynes SM, Longmuir KJ. PMID: 17932963.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    9. A practical guide to the staggered herringbone mixer. Lab Chip. 2008 Jul; 8(7):1121-9. Williams MS, Longmuir KJ, Yager P. PMID: 18584088; PMCID: PMC2792635.
      View in: PubMed   Mentions: 32     Fields:    
    10. Liposomal polyethyleneglycol and polyethyleneglycol-peptide combinations for active targeting to liver in vivo. Drug Deliv. 2008 May; 15(4):207-17. Haynes SM, Longmuir KJ, Robertson RT, Baratta JL, Waring AJ. PMID: 18446566.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    11. Effective targeting of liposomes to liver and hepatocytes in vivo by incorporation of a Plasmodium amino acid sequence. Pharm Res. 2006 Apr; 23(4):759-69. Longmuir KJ, Robertson RT, Haynes SM, Baratta JL, Waring AJ. PMID: 16550476.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    12. Using electroporation and lipid-mediated transfection of GFP-expressing plasmids to label embryonic avian cells for vital confocal and two-photon microscopy. Differentiation. 2002 Jun; 70(4-5):172-80. Dickinson ME, Murray BA, Haynes SM, Waters CW, Longmuir KJ. PMID: 12147137.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    13. Development of an effective gene delivery system: a study of complexes composed of a peptide-based amphiphilic DNA compaction agent and phospholipid. Nucleic Acids Res. 2001 Sep 01; 29(17):3694-704. Murphy EA, Waring AJ, Murphy JC, Willson RC, Longmuir KJ. PMID: 11522841; PMCID: PMC55880.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    14. Optimization of a peptide/non-cationic lipid gene delivery system for effective microinjection into chicken embryo in vivo. Mol Ther. 2001 Jul; 4(1):66-74. Longmuir KJ, Haynes SM, Dickinson ME, Murphy JC, Willson RC, Waring AJ. PMID: 11472108.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    15. Compaction of DNA in an anionic micelle environment followed by assembly into phosphatidylcholine liposomes. Nucleic Acids Res. 2000 Aug 01; 28(15):2986-92. Murphy EA, Waring AJ, Haynes SM, Longmuir KJ. PMID: 10908363; PMCID: PMC102676.
      View in: PubMed   Mentions: 10     Fields:    
    16. Keratinocyte growth factor is a growth factor for type II pneumocytes in vivo. J Clin Invest. 1994 Mar; 93(3):1298-306. Ulich TR, Yi ES, Longmuir K, Yin S, Biltz R, Morris CF, Housley RM, Pierce GF. PMID: 8132770; PMCID: PMC294086.
      View in: PubMed   Mentions: 74     Fields:    Translation:Animals
    17. Evidence that fatty acid chain length is a type II cell lipid-sorting signal. Am J Physiol. 1991 Feb; 260(2 Pt 1):L44-51. Longmuir KJ, Haynes S. PMID: 1996662.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    18. Surface properties of two rabbit lung lamellar body preparations with markedly different fatty acid profiles. Biochim Biophys Acta. 1990 Dec 04; 1047(3):284-9. Vodyanoy V, Bluestone GL, Longmuir KJ. PMID: 2252914.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    19. Cytokine- and calcium ionophore A23187-mediated arachidonic acid metabolism in neutrophils. Cytokine. 1990 Jul; 2(4):280-6. Ulich TR, Busser K, Longmuir KJ. PMID: 2129504.
      View in: PubMed   Mentions: 2  Translation:HumansAnimalsCells
    20. Mechanism of human lymphotoxin and tumor necrosis factor induced destruction of cells in vitro: phospholipase activation and deacylation of specific-membrane phospholipids. J Cell Physiol. 1990 Mar; 142(3):469-79. Knauer MF, Longmuir KJ, Yamamoto RS, Fitzgerald TP, Granger GA. PMID: 2107184.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    21. Transfer of phosphatidic acid from liposomes to cells is collision dependent. Am J Physiol. 1989 Mar; 256(3 Pt 1):C522-31. Longmuir KJ, Malinick LA. PMID: 2646942.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    22. Purification of long-chain, saturated, free fatty acids. J Chromatogr. 1988 Nov 11; 454:438-43. Longmuir KJ, Haynes S. PMID: 3235606.
      View in: PubMed   Mentions:    Fields:    
    23. Fatty acids of pulmonary surfactant phosphatidylcholine from fetal rabbit lung tissue in culture. Biosynthesis of n-10 monoenoic fatty acids. J Lipid Res. 1988 Aug; 29(8):1065-77. Longmuir KJ, Resele-Tiden C, Rossi ME. PMID: 3183519.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    24. Fatty acid chain-shortening activity in the pulmonary type II cell. Biochim Biophys Acta. 1988 Jul 01; 961(1):144-7. Longmuir KJ, Rossi ME. PMID: 3289622.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    25. Determination of monoenoic fatty acid double bond position by permanganate-periodate oxidation followed by high-performance liquid chromatography of carboxylic acid phenacyl esters. Anal Biochem. 1987 Dec; 167(2):213-21. Longmuir KJ, Rossi ME, Resele-Tiden C. PMID: 2831753.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    26. Phospholipases are activated during cell destruction by human alpha-lymphotoxin in vitro. Lymphokine Res. 1987; 6(4):319-24. Fitzgerald MT, Longmuir KJ, Granger GA. PMID: 3501507.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    27. Phosphorylation, transbilayer movement, and facilitated intracellular transport of diacylglycerol are involved in the uptake of a fluorescent analog of phosphatidic acid by cultured fibroblasts. J Biol Chem. 1985 Feb 10; 260(3):1909-16. Pagano RE, Longmuir KJ. PMID: 3968089.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    28. The phospholipids of lamellar body material from fetal rabbit lung tissue in culture. Unusual phosphatidylcholine fatty acid profile. Biochim Biophys Acta. 1985 Jan 09; 833(1):135-43. Longmuir KJ, Resele-Tiden C, Sykes A. PMID: 4038458.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    29. Synthesis of fluorescent and radiolabeled analogues of phosphatidic acid. Chem Phys Lipids. 1985 Jan; 36(3):197-207. Longmuir KJ, Martin OC, Pagano RE. PMID: 4006033.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    30. Hormonal regulation of the synthesis of lamellar body phosphatidylglycerol and phosphatidylinositol in fetal lung tissue. Endocrinology. 1983 Mar; 112(3):1012-8. Snyder JM, Longmuir KJ, Johnston JM, Mendelson CR. PMID: 6337040.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    31. Intracellular translocation and metabolism of a fluorescent phosphatidic acid analogue in cultured fibroblasts. J Biol Chem. 1983 Feb 10; 258(3):2034-40. Pagano RE, Longmuir KJ, Martin OC. PMID: 6822547.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    32. Regulation of lamellar body acidic glycerophospholipid biosynthesis in fetal rabbit lung in organ culture. Biochim Biophys Acta. 1982 Aug 18; 712(2):356-64. Longmuir KJ, Bleasdale JE, Quirk JG, Johnston JM. PMID: 7126609.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    33. Phospholipid composition of lamellar bodies formed by fetal rabbit lung type II cells in organ culture. Arch Biochem Biophys. 1981 Dec; 212(2):491-500. Longmuir KJ, Snyder JM, Mendelson CR, Johnston JM. PMID: 7325674.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    34. Metabolism and intracellular localization of a fluorescently labeled intermediate in lipid biosynthesis within cultured fibroblasts. J Cell Biol. 1981 Dec; 91(3 Pt 1):872-7. Pagano RE, Longmuir KJ, Martin OC, Struck DK. PMID: 7328126; PMCID: PMC2112803.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    35. Changes in CTP:phosphatidate cytidylyltransferase activity during rabbit lung development. Biochim Biophys Acta. 1980 Dec 05; 620(3):500-8. Longmuir KJ, Johnston JM. PMID: 6113006.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    36. Nuclear magnetic resonance studies of lipid-protein interactions. A model of the dynamics and energetics of phosphatidylcholine bilayers that contain cytochrome c oxidase. Biochemistry. 1977 Dec 27; 16(26):5746-55. Longmuir KJ, Capaldi RA, Dahlquist FW. PMID: 201275.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    37. Direct spectroscopic observation of inner and outer hydrocarbon chains of lipid bilayer vesicles. Proc Natl Acad Sci U S A. 1976 Aug; 73(8):2716-9. Longmuir KJ, Dahlquist FW. PMID: 1066684; PMCID: PMC430719.
      View in: PubMed   Mentions: 8     Fields:    
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