Kenneth M Baldwin

Title(s)Professor Emeritus, Physiology and Biophysics
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-5865
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    Collapse Research 
    Collapse Research Activities and Funding
    Epigenetic regulation of cardiac MHC gene locus
    NIH R01HL073473Apr 15, 2003 - Apr 30, 2012
    Role: Principal Investigator
    U.C. Irvine Multidisciplinary Exercise Science Training Program
    NIH T32AR047752Apr 1, 2001 - Apr 30, 2019
    Role: Co-Principal Investigator
    NEURAL-THYROID INTERACTION ON ISOMYOSIN EXPRESSION
    NIH U01NS033483Sep 20, 1995 - Jun 30, 2000
    Role: Principal Investigator
    INDUCED ADAPTATIONS IN MYOSIN PHENOTYPE AND MUSCLE MASS
    NIH R01AR043126Jul 10, 1995 - Jun 30, 2000
    Role: Principal Investigator
    ACTIVITY &METABOLIC CONTROL OF CARDIAC B MYOSIN
    NIH R01HL038819Jul 1, 1987 - Jun 30, 2003
    Role: Principal Investigator
    (In)activity-induced regulation of skeletal MHCs
    NIH R01AR030346Jul 1, 1982 - Feb 28, 2010
    Role: Principal Investigator
    MYOSIN ISOZYMES IN OVERLOADED SKELETAL MUSCLE
    NIH R01AM030346Jul 1, 1982 - Jun 30, 1988
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Regulation of myosin heavy chain antisense long noncoding RNA in human vastus lateralis in response to exercise training. Am J Physiol Cell Physiol. 2020 05 01; 318(5):C931-C942. Pandorf CE, Haddad F, Owerkowicz T, Carroll LP, Baldwin KM, Adams GR. PMID: 32130073; PMCID: PMC7294328.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    2. The historical context and scientific legacy of John O. Holloszy. J Appl Physiol (1985). 2019 08 01; 127(2):277-305. Hagberg JM, Coyle EF, Baldwin KM, Cartee GD, Fontana L, Joyner MJ, Kirwan JP, Seals DR, Weiss EP. PMID: 30730811; PMCID: PMC6732442.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    3. Triiodothyronine and leptin repletion in humans similarly reverse weight-loss-induced changes in skeletal muscle. Am J Physiol Endocrinol Metab. 2018 11 01; 315(5):E771-E779. Rosenbaum M, Goldsmith RL, Haddad F, Baldwin KM, Smiley R, Gallagher D, Leibel RL. PMID: 29920214; PMCID: PMC6293163.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    4. Concurrent exercise on a gravity-independent device during simulated microgravity. Med Sci Sports Exerc. 2015 May; 47(5):990-1000. Cotter JA, Yu A, Haddad F, Kreitenberg A, Baker MJ, Tesch PA, Baldwin KM, Caiozzo VJ, Adams GR. PMID: 25160844; PMCID: PMC4340828.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    5. Alterations in muscle mass and contractile phenotype in response to unloading models: role of transcriptional/pretranslational mechanisms. Front Physiol. 2013 Oct 11; 4:284. Baldwin KM, Haddad F, Pandorf CE, Roy RR, Edgerton VR. PMID: 24130531; PMCID: PMC3795307.
      View in: PubMed   Mentions: 69  
    6. Impaired translocation and activation of mitochondrial Akt1 mitigated mitochondrial oxidative phosphorylation Complex V activity in diabetic myocardium. J Mol Cell Cardiol. 2013 Jun; 59:167-75. Yang JY, Deng W, Chen Y, Fan W, Baldwin KM, Jope RS, Wallace DC, Wang PH. PMID: 23500391; PMCID: PMC3872535.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    7. Regulation of an antisense RNA with the transition of neonatal to IIb myosin heavy chain during postnatal development and hypothyroidism in rat skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2012 Apr; 302(7):R854-67. Pandorf CE, Jiang W, Qin AX, Bodell PW, Baldwin KM, Haddad F. PMID: 22262309; PMCID: PMC3330771.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    8. Effects of weight loss and leptin on skeletal muscle in human subjects. Am J Physiol Regul Integr Comp Physiol. 2011 Nov; 301(5):R1259-66. Baldwin KM, Joanisse DR, Haddad F, Goldsmith RL, Gallagher D, Pavlovich KH, Shamoon EL, Leibel RL, Rosenbaum M. PMID: 21917907; PMCID: PMC3213951.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    9. Electromechanical modulation of catabolic and anabolic pathways in chronically inactive, but neurally intact, muscles. Muscle Nerve. 2010 Sep; 42(3):410-21. Kim JA, Roy RR, Kim SJ, Zhong H, Haddad F, Baldwin KM, Edgerton VR. PMID: 20658566; PMCID: PMC2950751.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    10. Research in the exercise sciences: where we are and where do we go from here--Part II. Exerc Sport Sci Rev. 2010 Apr; 38(2):42-50. Baldwin KM, Haddad F. PMID: 20335735; PMCID: PMC2846553.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    11. A rationale for SDS-PAGE of MHC isoforms as a gold standard for determining contractile phenotype. J Appl Physiol (1985). 2010 Jan; 108(1):222-2; author reply 226. Pandorf CE, Caiozzo VJ, Haddad F, Baldwin KM. PMID: 20054086.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    12. Reverse transcription of the ribonucleic acid: the first step in RT-PCR assay. Methods Mol Biol. 2010; 630:261-70. Haddad F, Baldwin KM. PMID: 20301003.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    13. Transcriptional regulation of the myosin heavy chain IIb gene in inactive rat soleus. Muscle Nerve. 2009 Sep; 40(3):411-9. McCall GE, Haddad F, Roy RR, Zhong H, Edgerton VR, Baldwin KM. PMID: 19623632; PMCID: PMC2907261.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    14. The CAAT-binding transcription factor 1/nuclear factor 1 binding site is important in beta-myosin heavy chain antisense promoter regulation in rats. Exp Physiol. 2009 Dec; 94(12):1163-73. Giger JM, Bodell PW, Baldwin KM, Haddad F. PMID: 19684093; PMCID: PMC4792187.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    15. Calcineurin plays a modulatory role in loading-induced regulation of type I myosin heavy chain gene expression in slow skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2009 Oct; 297(4):R1037-48. Pandorf CE, Jiang WH, Qin AX, Bodell PW, Baldwin KM, Haddad F. PMID: 19657098; PMCID: PMC2763824.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    16. Rapid muscle atrophy response to unloading: pretranslational processes involving MHC and actin. J Appl Physiol (1985). 2009 Oct; 107(4):1204-12. Giger JM, Bodell PW, Zeng M, Baldwin KM, Haddad F. PMID: 19628726; PMCID: PMC2763827.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    17. Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading. Mol Cell Biol. 2009 Sep; 29(17):4798-811. Nakao R, Hirasaka K, Goto J, Ishidoh K, Yamada C, Ohno A, Okumura Y, Nonaka I, Yasutomo K, Baldwin KM, Kominami E, Higashibata A, Nagano K, Tanaka K, Yasui N, Mills EM, Takeda S, Nikawa T. PMID: 19546233; PMCID: PMC2725709.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    18. Differential epigenetic modifications of histones at the myosin heavy chain genes in fast and slow skeletal muscle fibers and in response to muscle unloading. Am J Physiol Cell Physiol. 2009 Jul; 297(1):C6-16. Pandorf CE, Haddad F, Wright C, Bodell PW, Baldwin KM. PMID: 19369448; PMCID: PMC2711647.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    19. Gene expression during inactivity-induced muscle atrophy: effects of brief bouts of a forceful contraction countermeasure. J Appl Physiol (1985). 2008 Oct; 105(4):1246-54. Kim SJ, Roy RR, Kim JA, Zhong H, Haddad F, Baldwin KM, Edgerton VR. PMID: 18653749; PMCID: PMC2576041.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    20. Intergenic bidirectional promoter and cooperative regulation of the IIx and IIb MHC genes in fast skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2008 Jul; 295(1):R208-18. Rinaldi C, Haddad F, Bodell PW, Qin AX, Jiang W, Baldwin KM. PMID: 18434443; PMCID: PMC2494810.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    21. Persistence of motor unit and muscle fiber types in the presence of inactivity. J Exp Biol. 2008 Apr; 211(Pt 7):1041-9. Roy RR, Pierotti DJ, Garfinkel A, Zhong H, Baldwin KM, Edgerton VR. PMID: 18344477; PMCID: PMC2898736.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    22. Intergenic transcription and developmental regulation of cardiac myosin heavy chain genes. Am J Physiol Heart Circ Physiol. 2008 Jan; 294(1):H29-40. Haddad F, Qin AX, Bodell PW, Jiang W, Giger JM, Baldwin KM. PMID: 17982008.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    23. IIx myosin heavy chain promoter regulation cannot be characterized in vivo by direct gene transfer. Am J Physiol Cell Physiol. 2007 Oct; 293(4):C1338-46. Pandorf CE, Haddad F, Qin AX, Baldwin KM. PMID: 17670891.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    24. Potential pitfalls in the accuracy of analysis of natural sense-antisense RNA pairs by reverse transcription-PCR. BMC Biotechnol. 2007 May 04; 7:21. Haddad F, Qin AX, Giger JM, Guo H, Baldwin KM. PMID: 17480233; PMCID: PMC1876213.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    25. Electromechanical stimulation ameliorates inactivity-induced adaptations in the medial gastrocnemius of adult rats. J Appl Physiol (1985). 2007 Jul; 103(1):195-205. Kim SJ, Roy RR, Zhong H, Suzuki H, Ambartsumyan L, Haddad F, Baldwin KM, Edgerton VR. PMID: 17431083.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    26. Activity of the beta-myosin heavy chain antisense promoter responds to diabetes and hypothyroidism. Am J Physiol Heart Circ Physiol. 2007 Jun; 292(6):H3065-71. Giger J, Qin AX, Bodell PW, Baldwin KM, Haddad F. PMID: 17307996.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    27. Molecular and cellular defects of skeletal muscle in an animal model of acute quadriplegic myopathy. Muscle Nerve. 2007 Jan; 35(1):55-65. Mozaffar T, Haddad F, Zeng M, Zhang LY, Adams GR, Baldwin KM. PMID: 16967495.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    28. Dynamics of myosin heavy chain gene regulation in slow skeletal muscle: role of natural antisense RNA. J Biol Chem. 2006 Dec 15; 281(50):38330-42. Pandorf CE, Haddad F, Roy RR, Qin AX, Edgerton VR, Baldwin KM. PMID: 17030512.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    29. Expression of insulin-like growth factor I, insulin-like growth factor binding proteins, and collagen mRNA in mechanically loaded plantaris tendon. J Appl Physiol (1985). 2006 Jul; 101(1):183-8. Olesen JL, Heinemeier KM, Haddad F, Langberg H, Flyvbjerg A, Kjaer M, Baldwin KM. PMID: 16782835.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    30. Activity-unrelated neural control of myogenic factors in a slow muscle. Muscle Nerve. 2006 Jan; 33(1):49-60. Hyatt JP, Roy RR, Baldwin KM, Wernig A, Edgerton VR. PMID: 16184607.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    31. Parallel and divergent adaptations of rat soleus and plantaris to chronic exercise and hypergravity. Am J Physiol Regul Integr Comp Physiol. 2006 Feb; 290(2):R442-8. Fuller PM, Baldwin KM, Fuller CA. PMID: 16179485.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    32. Effect of unloading on type I myosin heavy chain gene regulation in rat soleus muscle. J Appl Physiol (1985). 2005 Apr; 98(4):1185-94. Giger JM, Haddad F, Qin AX, Zeng M, Baldwin KM. PMID: 15591287.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    33. Cloning and sequencing of myosin heavy chain isoform cDNAs in golden-mantled ground squirrels: effects of hibernation on mRNA expression. J Appl Physiol (1985). 2004 Nov; 97(5):1985-91. Rourke BC, Qin A, Haddad F, Baldwin KM, Caiozzo VJ. PMID: 15298989.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    34. Effect of cyclosporin A treatment on the in vivo regulation of type I MHC gene expression. J Appl Physiol (1985). 2004 Aug; 97(2):475-83. Giger JM, Haddad F, Qin AX, Baldwin KM. PMID: 15247194.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    35. Skeletal muscle hypertrophy in response to isometric, lengthening, and shortening training bouts of equivalent duration. J Appl Physiol (1985). 2004 May; 96(5):1613-8. Adams GR, Cheng DC, Haddad F, Baldwin KM. PMID: 15075307.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    36. Hemodynamic and metabolic responses to hypergravity on a human-powered centrifuge. Aviat Space Environ Med. 2004 Feb; 75(2):101-8. Caiozzo VJ, Rose-Gottron C, Baldwin KM, Cooper D, Adams G, Hicks J, Kreitenberg A. PMID: 14960043.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    37. Skeletal muscle gene expression in space-flown rats. FASEB J. 2004 Mar; 18(3):522-4. Nikawa T, Ishidoh K, Hirasaka K, Ishihara I, Ikemoto M, Kano M, Kominami E, Nonaka I, Ogawa T, Adams GR, Baldwin KM, Yasui N, Kishi K, Takeda S. PMID: 14715702.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    38. Skeletal muscle unweighting: spaceflight and ground-based models. J Appl Physiol (1985). 2003 Dec; 95(6):2185-201. Adams GR, Caiozzo VJ, Baldwin KM. PMID: 14600160.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansAnimalsCells
    39. Role of antisense RNA in coordinating cardiac myosin heavy chain gene switching. J Biol Chem. 2003 Sep 26; 278(39):37132-8. Haddad F, Bodell PW, Qin AX, Giger JM, Baldwin KM. PMID: 12851393.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    40. Nerve activity-independent regulation of skeletal muscle atrophy: role of MyoD and myogenin in satellite cells and myonuclei. Am J Physiol Cell Physiol. 2003 Nov; 285(5):C1161-73. Hyatt JP, Roy RR, Baldwin KM, Edgerton VR. PMID: 12839833.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    41. Single-fiber myosin heavy chain polymorphism: how many patterns and what proportions? Am J Physiol Regul Integr Comp Physiol. 2003 Sep; 285(3):R570-80. Caiozzo VJ, Baker MJ, Huang K, Chou H, Wu YZ, Baldwin KM. PMID: 12738613.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    42. Isolation and characterization of a novel gene sfig in rat skeletal muscle up-regulated by spaceflight (STS-90). J Med Invest. 2003 Feb; 50(1-2):39-47. Kano M, Kitano T, Ikemoto M, Hirasaka K, Asanoma Y, Ogawa T, Takeda S, Nonaka I, Adams GR, Baldwin KM, Oarada M, Kishi K, Nikawa T. PMID: 12630567.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    43. Cellular and molecular responses to increased skeletal muscle loading after irradiation. Am J Physiol Cell Physiol. 2002 Oct; 283(4):C1182-95. Adams GR, Caiozzo VJ, Haddad F, Baldwin KM. PMID: 12225982.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    44. Effects of different activity and inactivity paradigms on myosin heavy chain gene expression in striated muscle. J Appl Physiol (1985). 2001 Jan; 90(1):345-57. Baldwin KM, Haddad F. PMID: 11133928.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimals
    45. Research in the exercise sciences: where do we go from here? J Appl Physiol (1985). 2000 Jan; 88(1):332-6. Baldwin KM. PMID: 10642398.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
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