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Kelvin W Gee

Title(s)Professor, Pharmaceutical Sciences
Address101 Theory, Suite 100
Irvine CA 92697-3958
Phone(949) 824-8009, 7710
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    Collapse Research 
    Collapse Research Activities and Funding
    Pain drugs based on nicotinic receptor subtype antagonists
    NIH/NIDA R01DA041454Sep 1, 2017 - Aug 31, 2020
    Role: Principal Investigator
    Neurosteroids as a standard medical countermeasure for OP poisoning
    NIH/NINDS U01NS102131Aug 1, 2017 - Apr 30, 2020
    Role: Principal Investigator
    Development of Dual GABAA and alpah7 Nicotinic Receptor Modulators for AD
    NIH/NIA U01AG032972Feb 1, 2009 - Jan 31, 2014
    Role: Principal Investigator
    Non-sedating modulators of GABA-A receptors for anxiety
    NIH/NIMH R21MH082241Jul 1, 2008 - Jun 30, 2010
    Role: Principal Investigator
    Optimization of allosteric modulators of nicotinic receptors
    NIH/NIMH R21MH080246May 9, 2007 - Jan 30, 2010
    Role: Principal Investigator
    Dual Allosteric Modulators of GABA-A and Nicotinic Receptors for Alzheimer's Dise
    NIH/NIA R21AG028800Aug 15, 2006 - Jul 31, 2008
    Role: Principal Investigator
    IDENTIFYING LIGANDS FOR A NOVEL GABAA RECEPTOR SUBTYPE
    NIH/NIMH R41MH060527Jun 1, 2000 - May 31, 2002
    Role: Principal Investigator
    STEROIDS, THE ESTRUS CYCLE, AND BRAIN EXCITABILITY
    NIH/NINDS R01NS025986Aug 1, 1989 - Jul 31, 1992
    Role: Principal Investigator
    CHARACTERIZATION OF A NOVEL BENZODIAZEPINE BINDING SITE
    NIH/NINDS R29NS024645Feb 1, 1988 - Jun 30, 1993
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor. Neurobiol Stress. 2020 May; 12:100207. Belelli D, Hogenkamp D, Gee KW, Lambert JJ. PMID: 32435660.
      View in: PubMed   Mentions:
    2. Positive allosteric modulation of the a7 nicotinic acetylcholine receptor as a treatment for cognitive deficits after traumatic brain injury. PLoS One. 2019; 14(10):e0223180. Titus DJ, Johnstone T, Johnson NH, London SH, Chapalamadugu M, Hogenkamp D, Gee KW, Atkins CM. PMID: 31581202.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. Enaminone Modulators of Extrasynaptic a4ß3d ?-Aminobutyric AcidA Receptors Reverse Electrographic Status Epilepticus in the Rat After Acute Organophosphorus Poisoning. Front Pharmacol. 2019; 10:560. Johnstone TBC, McCarren HS, Spampanato J, Dudek FE, McDonough JH, Hogenkamp D, Gee KW. PMID: 31178732.
      View in: PubMed   Mentions:
    4. Positive allosteric modulators of nonbenzodiazepine ?-aminobutyric acidA receptor subtypes for the treatment of chronic pain. Pain. 2019 Jan; 160(1):198-209. Johnstone TBC, Xie JY, Qu C, Wasiak DJ, Hogenkamp DJ, Porreca F, Gee KW. PMID: 30204648.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    5. Role of ß2/3-specific GABA-A receptor isoforms in the development of hippocampus kindling epileptogenesis. Epilepsy Behav. 2018 05; 82:57-63. Reddy DS, Yoshimura RF, Ramanathan G, Carver C, Johnstone TB, Hogenkamp DJ, Gee KW. PMID: 29587186.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    6. Allosteric modulation of nicotinic and GABAA receptor subtypes differentially modify autism-like behaviors in the BTBR mouse model. Neuropharmacology. 2017 Nov; 126:38-47. Yoshimura RF, Tran MB, Hogenkamp DJ, Ayala NL, Johnstone T, Dunnigan AJ, Gee TK, Gee KW. PMID: 28842344.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    7. First in human trial of a type I positive allosteric modulator of alpha7-nicotinic acetylcholine receptors: Pharmacokinetics, safety, and evidence for neurocognitive effect of AVL-3288. J Psychopharmacol. 2017 04; 31(4):434-441. Gee KW, Olincy A, Kanner R, Johnson L, Hogenkamp D, Harris J, Tran M, Edmonds SA, Sauer W, Yoshimura R, Johnstone T, Freedman R. PMID: 28196430.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCellsCTClinical Trials
    8. Pharmacological profile of a 17ß-heteroaryl-substituted neuroactive steroid. Psychopharmacology (Berl). 2014 Sep; 231(17):3517-24. Hogenkamp DJ, Tran MB, Yoshimura RF, Johnstone TB, Kanner R, Gee KW. PMID: 24682501.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    9. Design, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type I positive allosteric modulators of a7 nicotinic acetylcholine receptors. J Med Chem. 2013 Nov 14; 56(21):8352-65. Hogenkamp DJ, Ford-Hutchinson TA, Li WY, Whittemore ER, Yoshimura RF, Tran MB, Johnstone TB, Bascom GD, Rollins H, Lu L, Gee KW. PMID: 24098954.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    10. Limited central side effects of a ß-subunit subtype-selective GABAA receptor allosteric modulator. J Psychopharmacol. 2014 May; 28(5):472-8. Yoshimura RF, Tran MB, Hogenkamp DJ, Johnstone TB, Xie JY, Porreca F, Gee KW. PMID: 24108410.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    11. Diagnostic accuracy of preoperative alpha-fetoprotein as an ovarian tumor marker in children and adolescents: not as good as we thought? Pediatr Surg Int. 2013 Jul; 29(7):709-13. Loh AH, Gee KW, Chua JH. PMID: 23653236.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    12. The monoamine oxidase (MAO) inhibitor tranylcypromine enhances nicotine self-administration in rats through a mechanism independent of MAO inhibition. Neuropharmacology. 2011 Jul-Aug; 61(1-2):95-104. Lotfipour S, Arnold MM, Hogenkamp DJ, Gee KW, Belluzzi JD, Leslie FM. PMID: 21419142.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    13. Allosteric modulation of related ligand-gated ion channels synergistically induces long-term potentiation in the hippocampus and enhances cognition. J Pharmacol Exp Ther. 2011 Mar; 336(3):908-15. Johnstone TB, Gu Z, Yoshimura RF, Villegier AS, Hogenkamp DJ, Whittemore ER, Huang JC, Tran MB, Belluzzi JD, Yakel JL, Gee KW. PMID: 21159751.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    14. Limiting activity at beta1-subunit-containing GABAA receptor subtypes reduces ataxia. J Pharmacol Exp Ther. 2010 Mar; 332(3):1040-53. Gee KW, Tran MB, Hogenkamp DJ, Johnstone TB, Bagnera RE, Yoshimura RF, Huang JC, Belluzzi JD, Whittemore ER. PMID: 19940102.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    15. Negative allosteric modulation of nicotinic acetylcholine receptors blocks nicotine self-administration in rats. J Pharmacol Exp Ther. 2007 Dec; 323(3):907-15. Yoshimura RF, Hogenkamp DJ, Li WY, Tran MB, Belluzzi JD, Whittemore ER, Leslie FM, Gee KW. PMID: 17873105.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    16. Enaminone amides as novel orally active GABAA receptor modulators. J Med Chem. 2007 Jul 12; 50(14):3369-79. Hogenkamp DJ, Johnstone TB, Huang JC, Li WY, Tran M, Whittemore ER, Bagnera RE, Gee KW. PMID: 17571865.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    17. Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. Proc Natl Acad Sci U S A. 2007 May 08; 104(19):8059-64. Ng HJ, Whittemore ER, Tran MB, Hogenkamp DJ, Broide RS, Johnstone TB, Zheng L, Stevens KE, Gee KW. PMID: 17470817.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimals
    18. Reversible lipidization for the oral delivery of leu-enkephalin. J Drug Target. 2006 Apr; 14(3):127-36. Wang J, Hogenkamp DJ, Tran M, Li WY, Yoshimura RF, Johnstone TB, Shen WC, Gee KW. PMID: 16753826.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    19. Modifying quinolone antibiotics yields new anxiolytics. Nat Med. 2004 Jan; 10(1):31-2. Johnstone TB, Hogenkamp DJ, Coyne L, Su J, Halliwell RF, Tran MB, Yoshimura RF, Li WY, Wang J, Gee KW. PMID: 14647497.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    20. Academic entrepreneur--an oxymoron? Mol Interv. 2001 Oct; 1(4):186-8. Gee K. PMID: 14993339.
      View in: PubMed   Mentions:    Fields:    
    21. Behavioral characterization of Co 134444 (3alpha-hydroxy-21-(1'-imidazolyl)-3beta-methoxymethyl-5alpha- pregnan-20-one), a novel sedative-hypnotic neuroactive steroid. Psychopharmacology (Berl). 2001 May; 155(3):285-91. Vanover KE, Hogenkamp DJ, Lan NC, Gee KW, Carter RB. PMID: 11432691.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    22. Response-rate suppression in operant paradigm as predictor of soporific potency in rats and identification of three novel sedative-hypnotic neuroactive steroids. J Pharmacol Exp Ther. 1999 Dec; 291(3):1317-23. Vanover KE, Edgar DM, Seidel WF, Hogenkamp DJ, Fick DB, Lan NC, Gee KW, Carter RB. PMID: 10565857.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    23. Positive allosteric modulators of the GABA(A) receptor: differential interaction of benzodiazepines and neuroactive steroids with ethanol. Psychopharmacology (Berl). 1999 Jan; 141(1):77-82. Vanover KE, Suruki M, Robledo S, Huber M, Wieland S, Lan NC, Gee KW, Wood PL, Carter RB. PMID: 9952068.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    24. Anxiolytic and anticonvulsant activity of a synthetic neuroactive steroid Co 3-0593. Psychopharmacology (Berl). 1997 Nov; 134(1):46-54. Wieland S, Belluzzi J, Hawkinson JE, Hogenkamp D, Upasani R, Stein L, Wood PL, Gee KW, Lan NC. PMID: 9399366.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    25. CCD-3693: an orally bioavailable analog of the endogenous neuroactive steroid, pregnanolone, demonstrates potent sedative hypnotic actions in the rat. J Pharmacol Exp Ther. 1997 Jul; 282(1):420-9. Edgar DM, Seidel WF, Gee KW, Lan NC, Field G, Xia H, Hawkinson JE, Wieland S, Carter RB, Wood PL. PMID: 9223583.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    26. Partial agonism by 3alpha,21-dihydroxy-5beta-pregnan-20-one at the gamma-aminobutyric acidA receptor neurosteroid site. J Pharmacol Exp Ther. 1997 Jun; 281(3):1095-101. Xue BG, Whittemore ER, Park CH, Woodward RM, Lan NC, Gee KW. PMID: 9190841.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    27. Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor. J Pharmacol Exp Ther. 1997 Mar; 280(3):1284-95. Carter RB, Wood PL, Wieland S, Hawkinson JE, Belelli D, Lambert JJ, White HS, Wolf HH, Mirsadeghi S, Tahir SH, Bolger MB, Lan NC, Gee KW. PMID: 9067315.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimals
    28. Synthesis and in vitro activity of 3 beta-substituted-3 alpha-hydroxypregnan-20-ones: allosteric modulators of the GABAA receptor. J Med Chem. 1997 Jan 03; 40(1):61-72. Hogenkamp DJ, Tahir SH, Hawkinson JE, Upasani RB, Alauddin M, Kimbrough CL, Acosta-Burruel M, Whittemore ER, Woodward RM, Lan NC, Gee KW, Bolger MB. PMID: 9016329.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    29. Anxiolytic properties of endogenously occurring pregnanediols in two rodent models of anxiety. Psychopharmacology (Berl). 1996 Jul; 126(2):173-8. Carboni E, Wieland S, Lan NC, Gee KW. PMID: 8856837.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    30. 3 alpha-Hydroxy-3 beta-trifluoromethyl-5 alpha-pregnan-20-one (Co 2-1970): a partial agonist at the neuroactive steroid site of the gamma-aminobutyric acidA receptor. Mol Pharmacol. 1996 May; 49(5):897-906. Hawkinson JE, Drewe JA, Kimbrough CL, Chen JS, Hogenkamp DJ, Lan NC, Gee KW, Shen KZ, Whittemore ER, Woodward RM. PMID: 8622640.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    31. Loreclezole modulates [35S]t-butylbicyclophosphorothionate and [3H]flunitrazepam binding via a distinct site on the GABAA receptor complex. Eur J Pharmacol. 1996 Apr 04; 300(1-2):125-30. Xue BG, Friend JM, Gee KW. PMID: 8741177.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    32. Epalons as anticonvulsants: actions mediated by the GABAA receptor complex. Proc West Pharmacol Soc. 1996; 39:55. Gee KW. PMID: 8895969.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    33. Modulation of human recombinant GABAA receptors by pregnanediols. Neuropharmacology. 1996; 35(9-10):1223-31. Belelli D, Lambert JJ, Peters JA, Gee KW, Lan NC. PMID: 9014137.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    34. Characterization of peripheral benzodiazepine type sites in a cultured murine BV-2 microglial cell line. Glia. 1996 Jan; 16(1):65-70. Park CH, Carboni E, Wood PL, Gee KW. PMID: 8787774.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    35. Influence of the estrus cycle on the discrimination of apparent neuroactive steroid site subtypes on the gamma-aminobutyric acidA receptor complex in the rat. J Pharmacol Exp Ther. 1995 Dec; 275(3):1412-7. McCauley LD, Gee KW. PMID: 8531110.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    36. Potency of lipid and protein formulation of 5 alpha-pregnanolone at induction of anaesthesia and the corresponding regional brain distribution. Br J Anaesth. 1995 May; 74(5):553-7. Wang MD, Wahlström G, Gee KW, Bäckström T. PMID: 7772431.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    37. Benzodiazepines and peptides stimulate pregnenolone synthesis in brain mitochondria. Eur J Pharmacol. 1995 Mar 24; 276(1-2):145-53. McCauley LD, Park CH, Lan NC, Tomich JM, Shively JE, Gee KW. PMID: 7781684.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    38. Differential effects of 4'-chlorodiazepam on expressed human GABAA receptors. J Neurochem. 1995 Feb; 64(2):684-8. Lan NC, Chen JS, Johnson D, Gee KW. PMID: 7830061.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    39. Selective actions of certain neuroactive pregnanediols at the gamma-aminobutyric acid type A receptor complex in rat brain. Mol Pharmacol. 1995 Feb; 47(2):354-62. McCauley LD, Liu V, Chen JS, Hawkinson JE, Lan NC, Gee KW. PMID: 7870044.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    40. A putative receptor for neurosteroids on the GABAA receptor complex: the pharmacological properties and therapeutic potential of epalons. Crit Rev Neurobiol. 1995; 9(2-3):207-27. Gee KW, McCauley LD, Lan NC. PMID: 8581984.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    41. Neuroactive steroid actions at the GABAA receptor. Horm Behav. 1994 Dec; 28(4):537-44. Lan NC, Gee KW. PMID: 7729823.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    42. The neuroactive steroid 3 alpha-hydroxy-5 beta-pregnan-20-one is a two-component modulator of ligand binding to the GABAA receptor. Eur J Pharmacol. 1994 Oct 14; 269(2):157-63. Hawkinson JE, Kimbrough CL, McCauley LD, Bolger MB, Lan NC, Gee KW. PMID: 7851492.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    43. The estrus cycle, sensitivity to convulsants and the anticonvulsant effect of a neuroactive steroid. J Pharmacol Exp Ther. 1994 Oct; 271(1):164-70. Finn DA, Gee KW. PMID: 7965710.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    44. A comparison of Ro 16-6028 with benzodiazepine receptor 'full agonists' on GABAA receptor function. Eur J Pharmacol. 1993 Nov 15; 247(3):233-7. Finn DA, Gee KW. PMID: 7905829.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    45. The influence of estrus cycle on neurosteroid potency at the gamma-aminobutyric acidA receptor complex. J Pharmacol Exp Ther. 1993 Jun; 265(3):1374-9. Finn DA, Gee KW. PMID: 8389864.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    46. Complex interactions between the steroid derivative RU 5135 and the GABAA-receptor complex. Eur J Pharmacol. 1992 Oct 01; 227(2):147-51. Cadoni C, Gee KW. PMID: 1330646.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    47. Peripheral-type benzodiazepine receptors and the regulation of steroidogenesis in rat brain mitochondria. Adv Biochem Psychopharmacol. 1992; 47:143-7. McCauley LD, Lan NC, Tomich JM, Shively JE, Gee KW. PMID: 1324568.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    48. Pharmacology of a GABAA receptor coupled steroid recognition site. Adv Biochem Psychopharmacol. 1992; 47:111-7. Gee KW, Lan NC, Bolger MB, Wieland S, Belelli D, Chen JS. PMID: 1354914.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    49. Gamma-aminobutyric acidA receptor complexes in rat frontal cortex and spinal cord show differential responses to steroid modulation. Mol Pharmacol. 1991 Dec; 40(6):995-9. Gee KW, Lan NC. PMID: 1661843.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    50. Anxiolytic activity of the progesterone metabolite 5 alpha-pregnan-3 alpha-o1-20-one. Brain Res. 1991 Nov 29; 565(2):263-8. Wieland S, Lan NC, Mirasedeghi S, Gee KW. PMID: 1688192.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    51. Differential responses of expressed recombinant human gamma-aminobutyric acidA receptors to neurosteroids. J Neurochem. 1991 Nov; 57(5):1818-21. Lan NC, Gee KW, Bolger MB, Chen JS. PMID: 1655982.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    52. Identification and characterization of a pregnane steroid recognition site that is functionally coupled to an expressed GABAA receptor. Neurochem Res. 1991 Mar; 16(3):347-56. Lan NC, Bolger MB, Gee KW. PMID: 1664061.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    53. Heterotropic cooperativity between putative recognition sites for progesterone metabolites and the atypical benzodiazepine Ro 5-4864. J Neurochem. 1990 Jul; 55(1):83-7. Belelli D, McCauley L, Gee KW. PMID: 2113084.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    54. A steroid recognition site is functionally coupled to an expressed GABA(A)-benzodiazepine receptor. Eur J Pharmacol. 1990 Jun 12; 188(6):403-6. Lan NC, Chen JS, Belelli D, Pritchett DB, Seeburg PH, Gee KW. PMID: 2164942.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    55. Steroids in relation to epilepsy and anaesthesia. Ciba Found Symp. 1990; 153:225-30; discussion 230-9. Bäckström T, Gee KW, Lan N, Sörensen M, Wahlström G. PMID: 2292214.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    56. Anticonvulsant steroids and the GABA/benzodiazepine receptor-chloride ionophore complex. Neurosci Biobehav Rev. 1990; 14(3):315-22. Belelli D, Lan NC, Gee KW. PMID: 2172879.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    57. 5 alpha-pregnan-3 alpha,20 alpha-diol behaves like a partial agonist in the modulation of GABA-stimulated chloride ion uptake by synaptoneurosomes. Eur J Pharmacol. 1989 Aug 11; 167(1):173-6. Belelli D, Gee KW. PMID: 2550257.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    58. Anticonvulsant profile of the progesterone metabolite 5 alpha-pregnan-3 alpha-ol-20-one. Eur J Pharmacol. 1989 Jul 18; 166(2):325-9. Belelli D, Bolger MB, Gee KW. PMID: 2792198.
      View in: PubMed   Mentions: 64     Fields:    Translation:Animals
    59. Complex interactions between pregnenolone sulfate and the t-butylbicyclophosphorothionate-labeled chloride ionophore in rat brain. Brain Res. 1989 Mar 13; 482(1):169-73. Gee KW, Joy DS, Belelli D. PMID: 2539882.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    60. Effects of chronic delta-9-tetrahydrocannabinol (THC) administration on neurotransmitter concentrations and receptor binding in the rat brain. Neurotoxicology. 1989; 10(3):491-500. Ali SF, Newport GD, Scallet AC, Gee KW, Paule MG, Brown RM, Slikker W. PMID: 2576303.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    61. Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action. J Pharmacol Exp Ther. 1988 Aug; 246(2):803-12. Gee KW, Bolger MB, Brinton RE, Coirini H, McEwen BS. PMID: 2841455.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    62. Regional distribution of a Ro5 4864 binding site that is functionally coupled to the gamma-aminobutyric acid/benzodiazepine receptor complex in rat brain. J Pharmacol Exp Ther. 1988 Jan; 244(1):379-83. Gee KW, Brinton RE, McEwen BS. PMID: 2826772.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    63. GABA-dependent modulation of the Cl- ionophore by steroids in rat brain. Eur J Pharmacol. 1987 Apr 29; 136(3):419-23. Gee KW, Chang WC, Brinton RE, McEwen BS. PMID: 3609126.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    64. Phenylquinolines PK 8165 and PK 9084 allosterically modulate [35S]t-butylbicyclophosphorothionate binding to a chloride ionophore in rat brain via a novel Ro5 4864 binding site. J Pharmacol Exp Ther. 1987 Mar; 240(3):747-53. Gee KW. PMID: 3031273.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    65. Modulation of the chloride ionophore by benzodiazepine receptor ligands: influence of gamma-aminobutyric acid and ligand efficacy. Mol Pharmacol. 1986 Sep; 30(3):218-25. Gee KW, Lawrence LJ, Yamamura HI. PMID: 3018479.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    66. t-[3H]butylbicycloorthobenzoate: new radioligand probe for the gamma-aminobutyric acid-regulated chloride ionophore. J Neurochem. 1985 Sep; 45(3):798-804. Lawrence LJ, Palmer CJ, Gee KW, Wang X, Yamamura HI, Casida JE. PMID: 2993514.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    67. Characterization of [3H][2-D-penicillamine, 5-D-penicillamine]-enkephalin binding to delta opiate receptors in the rat brain and neuroblastoma--glioma hybrid cell line (NG 108-15). Proc Natl Acad Sci U S A. 1985 Apr; 82(8):2543-7. Akiyama K, Gee KW, Mosberg HI, Hruby VJ, Yamamura HI. PMID: 2986120.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    68. Interactions of pyrethroid insecticides with chloride ionophore-associated binding sites. Neurotoxicology. 1985; 6(2):87-98. Lawrence LJ, Gee KW, Yamamura HI. PMID: 2410833.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    69. Specific high-affinity [3H]Ro5-4864 Ro5-4864 benzodiazepine binding sites in the brain and periphery. Prog Clin Biol Res. 1985; 192:187-96. Yamamura HI, Gehlert DR, Gee KW, Wamsley JK, Horst WD, Roeske WR. PMID: 3001751.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    70. Benzodiazepine receptor heterogeneity: possible molecular basis and functional significance. Fed Proc. 1984 Oct; 43(13):2767-72. Gee KW, Yamamura SH, Roeske WR, Yamamura HI. PMID: 6090222.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    71. Benzodiazepine anticonvulsant action: gamma-aminobutyric acid-dependent modulation of the chloride ionophore. Biochem Biophys Res Commun. 1984 Sep 28; 123(3):1130-7. Lawrence LJ, Gee KW, Yamamura HI. PMID: 6091648.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    72. [3H]oxytocin binding sites in the rat brain demonstrated by quantitative light microscopic autoradiography. Eur J Pharmacol. 1984 Jul 13; 102(2):365-7. Brinton RE, Wamsley JK, Gee KW, Wan YP, Yamamura HI. PMID: 6090165.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    73. Comparison of the distribution of convulsant/barbiturate and benzodiazepine receptors using light microscopic autoradiography. Life Sci. 1983 Dec 05; 33(23):2321-9. Wamsley JK, Gee KW, Yamamura HI. PMID: 6316061.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    74. Photoaffinity labeling of benzodiazepine receptors in rat brain with flunitrazepam alters the affinity of benzodiazepine receptor agonist but not antagonist binding. J Neurochem. 1983 Nov; 41(5):1407-13. Gee KW, Yamamura HI. PMID: 6311986.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    75. An allosteric model for benzodiazepine receptor function. Biochem Pharmacol. 1983 Aug 15; 32(16):2375-83. Ehlert FJ, Roeske WR, Gee KW, Yamamura HI. PMID: 6311215.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    76. Light microscopic autoradiographic identification of picrotoxin/barbiturate binding sites in rat brain with [35S]t-butyl-bicyclophosphothionate. Eur J Pharmacol. 1983 May 06; 89(3-4):323-4. Gee KW, Wamsley JK, Yamamura HI. PMID: 6307715.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    77. Differential effect of gamma-aminobutyric acid on benzodiazepine receptor subtypes labeled by [3H]propyl beta-carboline-3-carboxylate in rat brain. J Pharmacol Exp Ther. 1983 Apr; 225(1):132-7. Gee KW, Ehlert FJ, Yamamura HI. PMID: 6300371.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    78. Effects of haloperidol-induced dopamine receptor supersensitivity on kindled seizure development. J Pharmacol Exp Ther. 1983 Apr; 225(1):70-6. Gee KW, Killam EK, Hollinger MA. PMID: 6834278.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    79. PK 8165 and PK 9084, two quinoline derivatives with anxiolytic properties, antagonize the anticonvulsant effects of diazepam. Brain Res. 1983 Mar 28; 264(1):168-72. Gee KW, Brinton RE, Yamamura HI. PMID: 6303496.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    80. CL 218872 antagonism of diazepam induced loss of righting reflex: evidence for partial agonistic activity at the benzodiazepine receptor. Life Sci. 1983 Feb 28; 32(9):1037-40. Gee KW, Brinton RE, Yamamura HI. PMID: 6298552.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    81. Selective anxiolytics: are the actions related to partial "agonist" activity or a preferential affinity for benzodiazepine receptor subtypes? Adv Biochem Psychopharmacol. 1983; 38:1-9. Gee KW, Yamamura HI. PMID: 6142598.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    82. Regional heterogeneity of benzodiazepine receptors at 37 degrees C: an in vitro study in various regions of the rat brain. Life Sci. 1982 Nov 01; 31(18):1939-45. Gee KW, Yamamura HI. PMID: 6294423.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    83. Differentiation of benzodiazepine receptor agonist and antagonist: sparing of [3H]benzodiazepine antagonist binding following the photolabelling of benzodiazepine receptors. Eur J Pharmacol. 1982 Aug 27; 82(3-4):239-41. Gee KW, Yamamura HI. PMID: 6290239.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    84. The effect of GABA on in vitro binding of two novel non-benzodiazepines, PK 8165 and CGS 8216, to benzodiazepine receptors in the rat brain. Life Sci. 1982 Jul 05; 31(1):77-81. Morelli M, Gee KW, Yamamura HI. PMID: 6287150.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    85. The influence of temperature and gamma-aminobutyric acid on benzodiazepine receptor subtypes in the hippocampus of the rat. Biochem Biophys Res Commun. 1982 Jun 30; 106(4):1134-40. Gee KW, Ehlert FJ, Yamamura HI. PMID: 6288041.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    86. A novel pyrazoloquinoline that interacts with brain benzodiazepine receptors: characterization of some in vitro and in vivo properties of CGS 9896. Life Sci. 1982 Jun 28; 30(26):2245-52. Gee KW, Yamamura HI. PMID: 6287145.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    87. The effect of temperature on CL 218872 and propyl beta-carboline-3-carboxylate inhibition of [3H]-flunitrazepam binding in rat brain. Biochem Biophys Res Commun. 1982 Apr 29; 105(4):1532-7. Gee KW, Morelli M, Yamamura HI. PMID: 6125147.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    88. High affinity inhibition of [3H]-flunitrazepam binding to brain benzodiazepine receptors by CGS 9896, a novel pyrazoloquinoline. Biochem Biophys Res Commun. 1982 Mar 30; 105(2):457-61. Gee KW, Horst WD, O'Brien R, Yamamura HI. PMID: 6124246.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    89. Effect of seizures kindled by subconvulsant doses of pentylenetetrazol on dopamine receptor binding and dopamine-sensitive adenylate cyclase in the rat. Exp Neurol. 1981 Oct; 74(1):265-75. Gee KW, Hollinger MA, Killam EK. PMID: 6269870.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    90. Comparison of the effects of phenoxybenzamine and morphine on the isolated guinea pig ileum. Proc West Pharmacol Soc. 1977; 20:389-91. Gee KW, Navarro G. PMID: 896845.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
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