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Kelvin W Gee

Title(s)Professor, Pharmacology
Phone(949) 824-8009, 7710, 5670
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    Collapse Research 
    Collapse Research Activities and Funding
    Pain drugs based on nicotinic receptor subtype antagonists
    NIH/NIDA R01DA041454Sep 1, 2017 - Aug 31, 2020
    Role: Principal Investigator
    Neurosteroids as a standard medical countermeasure for OP poisoning
    NIH/NINDS U01NS102131Aug 1, 2017 - Apr 30, 2020
    Role: Principal Investigator
    Development of Dual GABAA and alpah7 Nicotinic Receptor Modulators for AD
    NIH/NIA U01AG032972Feb 1, 2009 - Jan 31, 2014
    Role: Principal Investigator
    Non-sedating modulators of GABA-A receptors for anxiety
    NIH/NIMH R21MH082241Jul 1, 2008 - Jun 30, 2010
    Role: Principal Investigator
    Optimization of allosteric modulators of nicotinic receptors
    NIH/NIMH R21MH080246May 9, 2007 - Jan 30, 2010
    Role: Principal Investigator
    Dual Allosteric Modulators of GABA-A and Nicotinic Receptors for Alzheimer's Dise
    NIH/NIA R21AG028800Aug 15, 2006 - Jul 31, 2008
    Role: Principal Investigator
    IDENTIFYING LIGANDS FOR A NOVEL GABAA RECEPTOR SUBTYPE
    NIH/NIMH R41MH060527Jun 1, 2000 - May 31, 2002
    Role: Principal Investigator
    STEROIDS, THE ESTRUS CYCLE, AND BRAIN EXCITABILITY
    NIH/NINDS R01NS025986Aug 1, 1989 - Dec 31, 1992
    Role: Principal Investigator
    CHARACTERIZATION OF A NOVEL BENZODIAZEPINE BINDING SITE
    NIH/NINDS R29NS024645Feb 1, 1988 - Jun 30, 1993
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Titus DJ, Johnstone T, Johnson NH, London SH, Chapalamadugu M, Hogenkamp D, Gee KW, Atkins CM. Positive allosteric modulation of the a7 nicotinic acetylcholine receptor as a treatment for cognitive deficits after traumatic brain injury. PLoS One. 2019; 14(10):e0223180. PMID: 31581202.
      View in: PubMed
    2. Johnstone TBC, McCarren HS, Spampanato J, Dudek FE, McDonough JH, Hogenkamp D, Gee KW. Enaminone Modulators of Extrasynaptic a4ß3d ?-Aminobutyric AcidA Receptors Reverse Electrographic Status Epilepticus in the Rat After Acute Organophosphorus Poisoning. Front Pharmacol. 2019; 10:560. PMID: 31178732.
      View in: PubMed
    3. Johnstone TBC, Xie JY, Qu C, Wasiak DJ, Hogenkamp DJ, Porreca F, Gee KW. Positive allosteric modulators of nonbenzodiazepine ?-aminobutyric acidA receptor subtypes for the treatment of chronic pain. Pain. 2019 Jan; 160(1):198-209. PMID: 30204648.
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    4. Reddy DS, Yoshimura RF, Ramanathan G, Carver C, Johnstone TB, Hogenkamp DJ, Gee KW. Role of ß2/3-specific GABA-A receptor isoforms in the development of hippocampus kindling epileptogenesis. Epilepsy Behav. 2018 05; 82:57-63. PMID: 29587186.
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    5. Yoshimura RF, Tran MB, Hogenkamp DJ, Ayala NL, Johnstone T, Dunnigan AJ, Gee TK, Gee KW. Allosteric modulation of nicotinic and GABAA receptor subtypes differentially modify autism-like behaviors in the BTBR mouse model. Neuropharmacology. 2017 Nov; 126:38-47. PMID: 28842344.
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    6. Gee KW, Olincy A, Kanner R, Johnson L, Hogenkamp D, Harris J, Tran M, Edmonds SA, Sauer W, Yoshimura R, Johnstone T, Freedman R. First in human trial of a type I positive allosteric modulator of alpha7-nicotinic acetylcholine receptors: Pharmacokinetics, safety, and evidence for neurocognitive effect of AVL-3288. J Psychopharmacol. 2017 04; 31(4):434-441. PMID: 28196430.
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    7. Hogenkamp DJ, Tran MB, Yoshimura RF, Johnstone TB, Kanner R, Gee KW. Pharmacological profile of a 17ß-heteroaryl-substituted neuroactive steroid. Psychopharmacology (Berl). 2014 Sep; 231(17):3517-24. PMID: 24682501.
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    8. Hogenkamp DJ, Ford-Hutchinson TA, Li WY, Whittemore ER, Yoshimura RF, Tran MB, Johnstone TB, Bascom GD, Rollins H, Lu L, Gee KW. Design, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type I positive allosteric modulators of a7 nicotinic acetylcholine receptors. J Med Chem. 2013 Nov 14; 56(21):8352-65. PMID: 24098954.
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    9. Yoshimura RF, Tran MB, Hogenkamp DJ, Johnstone TB, Xie JY, Porreca F, Gee KW. Limited central side effects of a ß-subunit subtype-selective GABAA receptor allosteric modulator. J Psychopharmacol. 2014 May; 28(5):472-8. PMID: 24108410.
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    10. Loh AH, Gee KW, Chua JH. Diagnostic accuracy of preoperative alpha-fetoprotein as an ovarian tumor marker in children and adolescents: not as good as we thought? Pediatr Surg Int. 2013 Jul; 29(7):709-13. PMID: 23653236.
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    11. Lotfipour S, Arnold MM, Hogenkamp DJ, Gee KW, Belluzzi JD, Leslie FM. The monoamine oxidase (MAO) inhibitor tranylcypromine enhances nicotine self-administration in rats through a mechanism independent of MAO inhibition. Neuropharmacology. 2011 Jul-Aug; 61(1-2):95-104. PMID: 21419142.
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    12. Johnstone TB, Gu Z, Yoshimura RF, Villegier AS, Hogenkamp DJ, Whittemore ER, Huang JC, Tran MB, Belluzzi JD, Yakel JL, Gee KW. Allosteric modulation of related ligand-gated ion channels synergistically induces long-term potentiation in the hippocampus and enhances cognition. J Pharmacol Exp Ther. 2011 Mar; 336(3):908-15. PMID: 21159751.
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    13. Gee KW, Tran MB, Hogenkamp DJ, Johnstone TB, Bagnera RE, Yoshimura RF, Huang JC, Belluzzi JD, Whittemore ER. Limiting activity at beta1-subunit-containing GABAA receptor subtypes reduces ataxia. J Pharmacol Exp Ther. 2010 Mar; 332(3):1040-53. PMID: 19940102.
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    14. Yoshimura RF, Hogenkamp DJ, Li WY, Tran MB, Belluzzi JD, Whittemore ER, Leslie FM, Gee KW. Negative allosteric modulation of nicotinic acetylcholine receptors blocks nicotine self-administration in rats. J Pharmacol Exp Ther. 2007 Dec; 323(3):907-15. PMID: 17873105.
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    15. Hogenkamp DJ, Johnstone TB, Huang JC, Li WY, Tran M, Whittemore ER, Bagnera RE, Gee KW. Enaminone amides as novel orally active GABAA receptor modulators. J Med Chem. 2007 Jul 12; 50(14):3369-79. PMID: 17571865.
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    16. Ng HJ, Whittemore ER, Tran MB, Hogenkamp DJ, Broide RS, Johnstone TB, Zheng L, Stevens KE, Gee KW. Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. Proc Natl Acad Sci U S A. 2007 May 08; 104(19):8059-64. PMID: 17470817.
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    17. Wang J, Hogenkamp DJ, Tran M, Li WY, Yoshimura RF, Johnstone TB, Shen WC, Gee KW. Reversible lipidization for the oral delivery of leu-enkephalin. J Drug Target. 2006 Apr; 14(3):127-36. PMID: 16753826.
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    18. Johnstone TB, Hogenkamp DJ, Coyne L, Su J, Halliwell RF, Tran MB, Yoshimura RF, Li WY, Wang J, Gee KW. Modifying quinolone antibiotics yields new anxiolytics. Nat Med. 2004 Jan; 10(1):31-2. PMID: 14647497.
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    19. Gee K. Academic entrepreneur--an oxymoron? Mol Interv. 2001 Oct; 1(4):186-8. PMID: 14993339.
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    20. Vanover KE, Hogenkamp DJ, Lan NC, Gee KW, Carter RB. Behavioral characterization of Co 134444 (3alpha-hydroxy-21-(1'-imidazolyl)-3beta-methoxymethyl-5alpha- pregnan-20-one), a novel sedative-hypnotic neuroactive steroid. Psychopharmacology (Berl). 2001 May; 155(3):285-91. PMID: 11432691.
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    21. Vanover KE, Edgar DM, Seidel WF, Hogenkamp DJ, Fick DB, Lan NC, Gee KW, Carter RB. Response-rate suppression in operant paradigm as predictor of soporific potency in rats and identification of three novel sedative-hypnotic neuroactive steroids. J Pharmacol Exp Ther. 1999 Dec; 291(3):1317-23. PMID: 10565857.
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    22. Vanover KE, Suruki M, Robledo S, Huber M, Wieland S, Lan NC, Gee KW, Wood PL, Carter RB. Positive allosteric modulators of the GABA(A) receptor: differential interaction of benzodiazepines and neuroactive steroids with ethanol. Psychopharmacology (Berl). 1999 Jan; 141(1):77-82. PMID: 9952068.
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    23. Wieland S, Belluzzi J, Hawkinson JE, Hogenkamp D, Upasani R, Stein L, Wood PL, Gee KW, Lan NC. Anxiolytic and anticonvulsant activity of a synthetic neuroactive steroid Co 3-0593. Psychopharmacology (Berl). 1997 Nov; 134(1):46-54. PMID: 9399366.
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    24. Edgar DM, Seidel WF, Gee KW, Lan NC, Field G, Xia H, Hawkinson JE, Wieland S, Carter RB, Wood PL. CCD-3693: an orally bioavailable analog of the endogenous neuroactive steroid, pregnanolone, demonstrates potent sedative hypnotic actions in the rat. J Pharmacol Exp Ther. 1997 Jul; 282(1):420-9. PMID: 9223583.
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    25. Xue BG, Whittemore ER, Park CH, Woodward RM, Lan NC, Gee KW. Partial agonism by 3alpha,21-dihydroxy-5beta-pregnan-20-one at the gamma-aminobutyric acidA receptor neurosteroid site. J Pharmacol Exp Ther. 1997 Jun; 281(3):1095-101. PMID: 9190841.
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    26. Carter RB, Wood PL, Wieland S, Hawkinson JE, Belelli D, Lambert JJ, White HS, Wolf HH, Mirsadeghi S, Tahir SH, Bolger MB, Lan NC, Gee KW. Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor. J Pharmacol Exp Ther. 1997 Mar; 280(3):1284-95. PMID: 9067315.
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    27. Hogenkamp DJ, Tahir SH, Hawkinson JE, Upasani RB, Alauddin M, Kimbrough CL, Acosta-Burruel M, Whittemore ER, Woodward RM, Lan NC, Gee KW, Bolger MB. Synthesis and in vitro activity of 3 beta-substituted-3 alpha-hydroxypregnan-20-ones: allosteric modulators of the GABAA receptor. J Med Chem. 1997 Jan 03; 40(1):61-72. PMID: 9016329.
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    28. Carboni E, Wieland S, Lan NC, Gee KW. Anxiolytic properties of endogenously occurring pregnanediols in two rodent models of anxiety. Psychopharmacology (Berl). 1996 Jul; 126(2):173-8. PMID: 8856837.
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    29. Hawkinson JE, Drewe JA, Kimbrough CL, Chen JS, Hogenkamp DJ, Lan NC, Gee KW, Shen KZ, Whittemore ER, Woodward RM. 3 alpha-Hydroxy-3 beta-trifluoromethyl-5 alpha-pregnan-20-one (Co 2-1970): a partial agonist at the neuroactive steroid site of the gamma-aminobutyric acidA receptor. Mol Pharmacol. 1996 May; 49(5):897-906. PMID: 8622640.
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    30. Xue BG, Friend JM, Gee KW. Loreclezole modulates [35S]t-butylbicyclophosphorothionate and [3H]flunitrazepam binding via a distinct site on the GABAA receptor complex. Eur J Pharmacol. 1996 Apr 04; 300(1-2):125-30. PMID: 8741177.
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    31. Gee KW. Epalons as anticonvulsants: actions mediated by the GABAA receptor complex. Proc West Pharmacol Soc. 1996; 39:55. PMID: 8895969.
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    32. Park CH, Carboni E, Wood PL, Gee KW. Characterization of peripheral benzodiazepine type sites in a cultured murine BV-2 microglial cell line. Glia. 1996 Jan; 16(1):65-70. PMID: 8787774.
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    33. Belelli D, Lambert JJ, Peters JA, Gee KW, Lan NC. Modulation of human recombinant GABAA receptors by pregnanediols. Neuropharmacology. 1996; 35(9-10):1223-31. PMID: 9014137.
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    34. McCauley LD, Gee KW. Influence of the estrus cycle on the discrimination of apparent neuroactive steroid site subtypes on the gamma-aminobutyric acidA receptor complex in the rat. J Pharmacol Exp Ther. 1995 Dec; 275(3):1412-7. PMID: 8531110.
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    35. Wang MD, Wahlström G, Gee KW, Bäckström T. Potency of lipid and protein formulation of 5 alpha-pregnanolone at induction of anaesthesia and the corresponding regional brain distribution. Br J Anaesth. 1995 May; 74(5):553-7. PMID: 7772431.
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    36. McCauley LD, Park CH, Lan NC, Tomich JM, Shively JE, Gee KW. Benzodiazepines and peptides stimulate pregnenolone synthesis in brain mitochondria. Eur J Pharmacol. 1995 Mar 24; 276(1-2):145-53. PMID: 7781684.
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    37. Lan NC, Chen JS, Johnson D, Gee KW. Differential effects of 4'-chlorodiazepam on expressed human GABAA receptors. J Neurochem. 1995 Feb; 64(2):684-8. PMID: 7830061.
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    38. McCauley LD, Liu V, Chen JS, Hawkinson JE, Lan NC, Gee KW. Selective actions of certain neuroactive pregnanediols at the gamma-aminobutyric acid type A receptor complex in rat brain. Mol Pharmacol. 1995 Feb; 47(2):354-62. PMID: 7870044.
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    39. Gee KW, McCauley LD, Lan NC. A putative receptor for neurosteroids on the GABAA receptor complex: the pharmacological properties and therapeutic potential of epalons. Crit Rev Neurobiol. 1995; 9(2-3):207-27. PMID: 8581984.
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    40. Lan NC, Gee KW. Neuroactive steroid actions at the GABAA receptor. Horm Behav. 1994 Dec; 28(4):537-44. PMID: 7729823.
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    41. Hawkinson JE, Kimbrough CL, McCauley LD, Bolger MB, Lan NC, Gee KW. The neuroactive steroid 3 alpha-hydroxy-5 beta-pregnan-20-one is a two-component modulator of ligand binding to the GABAA receptor. Eur J Pharmacol. 1994 Oct 14; 269(2):157-63. PMID: 7851492.
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    42. Finn DA, Gee KW. The estrus cycle, sensitivity to convulsants and the anticonvulsant effect of a neuroactive steroid. J Pharmacol Exp Ther. 1994 Oct; 271(1):164-70. PMID: 7965710.
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    43. Finn DA, Gee KW. A comparison of Ro 16-6028 with benzodiazepine receptor 'full agonists' on GABAA receptor function. Eur J Pharmacol. 1993 Nov 15; 247(3):233-7. PMID: 7905829.
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    44. Finn DA, Gee KW. The influence of estrus cycle on neurosteroid potency at the gamma-aminobutyric acidA receptor complex. J Pharmacol Exp Ther. 1993 Jun; 265(3):1374-9. PMID: 8389864.
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    45. Cadoni C, Gee KW. Complex interactions between the steroid derivative RU 5135 and the GABAA-receptor complex. Eur J Pharmacol. 1992 Oct 01; 227(2):147-51. PMID: 1330646.
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    46. McCauley LD, Lan NC, Tomich JM, Shively JE, Gee KW. Peripheral-type benzodiazepine receptors and the regulation of steroidogenesis in rat brain mitochondria. Adv Biochem Psychopharmacol. 1992; 47:143-7. PMID: 1324568.
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    47. Gee KW, Lan NC, Bolger MB, Wieland S, Belelli D, Chen JS. Pharmacology of a GABAA receptor coupled steroid recognition site. Adv Biochem Psychopharmacol. 1992; 47:111-7. PMID: 1354914.
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    48. Gee KW, Lan NC. Gamma-aminobutyric acidA receptor complexes in rat frontal cortex and spinal cord show differential responses to steroid modulation. Mol Pharmacol. 1991 Dec; 40(6):995-9. PMID: 1661843.
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    49. Wieland S, Lan NC, Mirasedeghi S, Gee KW. Anxiolytic activity of the progesterone metabolite 5 alpha-pregnan-3 alpha-o1-20-one. Brain Res. 1991 Nov 29; 565(2):263-8. PMID: 1688192.
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    50. Lan NC, Gee KW, Bolger MB, Chen JS. Differential responses of expressed recombinant human gamma-aminobutyric acidA receptors to neurosteroids. J Neurochem. 1991 Nov; 57(5):1818-21. PMID: 1655982.
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    51. Lan NC, Bolger MB, Gee KW. Identification and characterization of a pregnane steroid recognition site that is functionally coupled to an expressed GABAA receptor. Neurochem Res. 1991 Mar; 16(3):347-56. PMID: 1664061.
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    52. Belelli D, McCauley L, Gee KW. Heterotropic cooperativity between putative recognition sites for progesterone metabolites and the atypical benzodiazepine Ro 5-4864. J Neurochem. 1990 Jul; 55(1):83-7. PMID: 2113084.
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    53. Lan NC, Chen JS, Belelli D, Pritchett DB, Seeburg PH, Gee KW. A steroid recognition site is functionally coupled to an expressed GABA(A)-benzodiazepine receptor. Eur J Pharmacol. 1990 Jun 12; 188(6):403-6. PMID: 2164942.
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    54. Belelli D, Lan NC, Gee KW. Anticonvulsant steroids and the GABA/benzodiazepine receptor-chloride ionophore complex. Neurosci Biobehav Rev. 1990; 14(3):315-22. PMID: 2172879.
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    55. Bäckström T, Gee KW, Lan N, Sörensen M, Wahlström G. Steroids in relation to epilepsy and anaesthesia. Ciba Found Symp. 1990; 153:225-30; discussion 230-9. PMID: 2292214.
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    56. Belelli D, Gee KW. 5 alpha-pregnan-3 alpha,20 alpha-diol behaves like a partial agonist in the modulation of GABA-stimulated chloride ion uptake by synaptoneurosomes. Eur J Pharmacol. 1989 Aug 11; 167(1):173-6. PMID: 2550257.
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    57. Belelli D, Bolger MB, Gee KW. Anticonvulsant profile of the progesterone metabolite 5 alpha-pregnan-3 alpha-ol-20-one. Eur J Pharmacol. 1989 Jul 18; 166(2):325-9. PMID: 2792198.
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    58. Gee KW, Joy DS, Belelli D. Complex interactions between pregnenolone sulfate and the t-butylbicyclophosphorothionate-labeled chloride ionophore in rat brain. Brain Res. 1989 Mar 13; 482(1):169-73. PMID: 2539882.
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    59. Ali SF, Newport GD, Scallet AC, Gee KW, Paule MG, Brown RM, Slikker W. Effects of chronic delta-9-tetrahydrocannabinol (THC) administration on neurotransmitter concentrations and receptor binding in the rat brain. Neurotoxicology. 1989; 10(3):491-500. PMID: 2576303.
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    60. Gee KW, Bolger MB, Brinton RE, Coirini H, McEwen BS. Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action. J Pharmacol Exp Ther. 1988 Aug; 246(2):803-12. PMID: 2841455.
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    61. Gee KW, Brinton RE, McEwen BS. Regional distribution of a Ro5 4864 binding site that is functionally coupled to the gamma-aminobutyric acid/benzodiazepine receptor complex in rat brain. J Pharmacol Exp Ther. 1988 Jan; 244(1):379-83. PMID: 2826772.
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    62. Gee KW, Chang WC, Brinton RE, McEwen BS. GABA-dependent modulation of the Cl- ionophore by steroids in rat brain. Eur J Pharmacol. 1987 Apr 29; 136(3):419-23. PMID: 3609126.
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    63. Gee KW. Phenylquinolines PK 8165 and PK 9084 allosterically modulate [35S]t-butylbicyclophosphorothionate binding to a chloride ionophore in rat brain via a novel Ro5 4864 binding site. J Pharmacol Exp Ther. 1987 Mar; 240(3):747-53. PMID: 3031273.
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    64. Gee KW, Lawrence LJ, Yamamura HI. Modulation of the chloride ionophore by benzodiazepine receptor ligands: influence of gamma-aminobutyric acid and ligand efficacy. Mol Pharmacol. 1986 Sep; 30(3):218-25. PMID: 3018479.
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    65. Lawrence LJ, Palmer CJ, Gee KW, Wang X, Yamamura HI, Casida JE. t-[3H]butylbicycloorthobenzoate: new radioligand probe for the gamma-aminobutyric acid-regulated chloride ionophore. J Neurochem. 1985 Sep; 45(3):798-804. PMID: 2993514.
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    66. Akiyama K, Gee KW, Mosberg HI, Hruby VJ, Yamamura HI. Characterization of [3H][2-D-penicillamine, 5-D-penicillamine]-enkephalin binding to delta opiate receptors in the rat brain and neuroblastoma--glioma hybrid cell line (NG 108-15). Proc Natl Acad Sci U S A. 1985 Apr; 82(8):2543-7. PMID: 2986120.
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    67. Lawrence LJ, Gee KW, Yamamura HI. Interactions of pyrethroid insecticides with chloride ionophore-associated binding sites. Neurotoxicology. 1985; 6(2):87-98. PMID: 2410833.
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    68. Yamamura HI, Gehlert DR, Gee KW, Wamsley JK, Horst WD, Roeske WR. Specific high-affinity [3H]Ro5-4864 Ro5-4864 benzodiazepine binding sites in the brain and periphery. Prog Clin Biol Res. 1985; 192:187-96. PMID: 3001751.
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    69. Gee KW, Yamamura SH, Roeske WR, Yamamura HI. Benzodiazepine receptor heterogeneity: possible molecular basis and functional significance. Fed Proc. 1984 Oct; 43(13):2767-72. PMID: 6090222.
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    70. Lawrence LJ, Gee KW, Yamamura HI. Benzodiazepine anticonvulsant action: gamma-aminobutyric acid-dependent modulation of the chloride ionophore. Biochem Biophys Res Commun. 1984 Sep 28; 123(3):1130-7. PMID: 6091648.
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    71. Brinton RE, Wamsley JK, Gee KW, Wan YP, Yamamura HI. [3H]oxytocin binding sites in the rat brain demonstrated by quantitative light microscopic autoradiography. Eur J Pharmacol. 1984 Jul 13; 102(2):365-7. PMID: 6090165.
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    72. Wamsley JK, Gee KW, Yamamura HI. Comparison of the distribution of convulsant/barbiturate and benzodiazepine receptors using light microscopic autoradiography. Life Sci. 1983 Dec 05; 33(23):2321-9. PMID: 6316061.
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    73. Gee KW, Yamamura HI. Photoaffinity labeling of benzodiazepine receptors in rat brain with flunitrazepam alters the affinity of benzodiazepine receptor agonist but not antagonist binding. J Neurochem. 1983 Nov; 41(5):1407-13. PMID: 6311986.
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    74. Ehlert FJ, Roeske WR, Gee KW, Yamamura HI. An allosteric model for benzodiazepine receptor function. Biochem Pharmacol. 1983 Aug 15; 32(16):2375-83. PMID: 6311215.
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    75. Gee KW, Wamsley JK, Yamamura HI. Light microscopic autoradiographic identification of picrotoxin/barbiturate binding sites in rat brain with [35S]t-butyl-bicyclophosphothionate. Eur J Pharmacol. 1983 May 06; 89(3-4):323-4. PMID: 6307715.
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    76. Gee KW, Ehlert FJ, Yamamura HI. Differential effect of gamma-aminobutyric acid on benzodiazepine receptor subtypes labeled by [3H]propyl beta-carboline-3-carboxylate in rat brain. J Pharmacol Exp Ther. 1983 Apr; 225(1):132-7. PMID: 6300371.
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    77. Gee KW, Killam EK, Hollinger MA. Effects of haloperidol-induced dopamine receptor supersensitivity on kindled seizure development. J Pharmacol Exp Ther. 1983 Apr; 225(1):70-6. PMID: 6834278.
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    78. Gee KW, Brinton RE, Yamamura HI. PK 8165 and PK 9084, two quinoline derivatives with anxiolytic properties, antagonize the anticonvulsant effects of diazepam. Brain Res. 1983 Mar 28; 264(1):168-72. PMID: 6303496.
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    79. Gee KW, Brinton RE, Yamamura HI. CL 218872 antagonism of diazepam induced loss of righting reflex: evidence for partial agonistic activity at the benzodiazepine receptor. Life Sci. 1983 Feb 28; 32(9):1037-40. PMID: 6298552.
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    80. Gee KW, Yamamura HI. Selective anxiolytics: are the actions related to partial "agonist" activity or a preferential affinity for benzodiazepine receptor subtypes? Adv Biochem Psychopharmacol. 1983; 38:1-9. PMID: 6142598.
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    81. Gee KW, Yamamura HI. Regional heterogeneity of benzodiazepine receptors at 37 degrees C: an in vitro study in various regions of the rat brain. Life Sci. 1982 Nov 01; 31(18):1939-45. PMID: 6294423.
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    82. Gee KW, Yamamura HI. Differentiation of benzodiazepine receptor agonist and antagonist: sparing of [3H]benzodiazepine antagonist binding following the photolabelling of benzodiazepine receptors. Eur J Pharmacol. 1982 Aug 27; 82(3-4):239-41. PMID: 6290239.
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    83. Morelli M, Gee KW, Yamamura HI. The effect of GABA on in vitro binding of two novel non-benzodiazepines, PK 8165 and CGS 8216, to benzodiazepine receptors in the rat brain. Life Sci. 1982 Jul 05; 31(1):77-81. PMID: 6287150.
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    84. Gee KW, Ehlert FJ, Yamamura HI. The influence of temperature and gamma-aminobutyric acid on benzodiazepine receptor subtypes in the hippocampus of the rat. Biochem Biophys Res Commun. 1982 Jun 30; 106(4):1134-40. PMID: 6288041.
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    85. Gee KW, Yamamura HI. A novel pyrazoloquinoline that interacts with brain benzodiazepine receptors: characterization of some in vitro and in vivo properties of CGS 9896. Life Sci. 1982 Jun 28; 30(26):2245-52. PMID: 6287145.
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    86. Gee KW, Morelli M, Yamamura HI. The effect of temperature on CL 218872 and propyl beta-carboline-3-carboxylate inhibition of [3H]-flunitrazepam binding in rat brain. Biochem Biophys Res Commun. 1982 Apr 29; 105(4):1532-7. PMID: 6125147.
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    87. Gee KW, Horst WD, O'Brien R, Yamamura HI. High affinity inhibition of [3H]-flunitrazepam binding to brain benzodiazepine receptors by CGS 9896, a novel pyrazoloquinoline. Biochem Biophys Res Commun. 1982 Mar 30; 105(2):457-61. PMID: 6124246.
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    88. Gee KW, Hollinger MA, Killam EK. Effect of seizures kindled by subconvulsant doses of pentylenetetrazol on dopamine receptor binding and dopamine-sensitive adenylate cyclase in the rat. Exp Neurol. 1981 Oct; 74(1):265-75. PMID: 6269870.
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