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Gee, Kelvin W.

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentPharmacology
Address1001 Health Sciences Road
CA 92697-3950
Phone(949) 824-8009, 7710, 5670
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    Collapse Research 
    Collapse Research Activities and Funding
    Pain drugs based on nicotinic receptor subtype antagonists
    NIH/NIDA R01DA041454Sep 1, 2017 - Aug 31, 2020
    Role: Principal Investigator
    Neurosteroids as a standard medical countermeasure for OP poisoning
    NIH/NINDS U01NS102131Aug 1, 2017 - Apr 30, 2020
    Role: Principal Investigator
    Development of Dual GABAA and alpah7 Nicotinic Receptor Modulators for AD
    NIH/NIA U01AG032972Feb 1, 2009 - Jan 31, 2014
    Role: Principal Investigator
    Non-sedating modulators of GABA-A receptors for anxiety
    NIH/NIMH R21MH082241Jul 1, 2008 - Jun 30, 2010
    Role: Principal Investigator
    Optimization of allosteric modulators of nicotinic receptors
    NIH/NIMH R21MH080246May 9, 2007 - Jan 30, 2010
    Role: Principal Investigator
    Dual Allosteric Modulators of GABA-A and Nicotinic Receptors for Alzheimer's Dise
    NIH/NIA R21AG028800Aug 15, 2006 - Jul 31, 2008
    Role: Principal Investigator
    IDENTIFYING LIGANDS FOR A NOVEL GABAA RECEPTOR SUBTYPE
    NIH/NIMH R41MH060527Jun 1, 2000 - May 31, 2002
    Role: Principal Investigator
    STEROIDS, THE ESTRUS CYCLE, AND BRAIN EXCITABILITY
    NIH/NINDS R01NS025986Aug 1, 1989 - Dec 31, 1992
    Role: Principal Investigator
    CHARACTERIZATION OF A NOVEL BENZODIAZEPINE BINDING SITE
    NIH/NINDS R29NS024645Feb 1, 1988 - Jun 30, 1993
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Reddy DS, Yoshimura RF, Ramanathan G, Carver C, Johnstone TB, Hogenkamp DJ, Gee K. Role of ß2/3-specific GABA-A receptor isoforms in the development of hippocampus kindling epileptogenesis. Epilepsy Behav. 2018 May; 82:57-63. PMID: 29587186.
      View in: PubMed
    2. Yoshimura RF, Tran MB, Hogenkamp DJ, Ayala NL, Johnstone T, Dunnigan AJ, Gee TK, Gee K. Allosteric modulation of nicotinic and GABAA receptor subtypes differentially modify autism-like behaviors in the BTBR mouse model. Neuropharmacology. 2017 Nov; 126:38-47. PMID: 28842344.
      View in: PubMed
    3. Gee K, Olincy A, Kanner R, Johnson L, Hogenkamp D, Harris J, Tran M, Edmonds SA, Sauer W, Yoshimura R, Johnstone T, Freedman R. First in human trial of a type I positive allosteric modulator of alpha7-nicotinic acetylcholine receptors: Pharmacokinetics, safety, and evidence for neurocognitive effect of AVL-3288. J Psychopharmacol. 2017 04; 31(4):434-441. PMID: 28196430.
      View in: PubMed
    4. Hogenkamp DJ, Tran MB, Yoshimura RF, Johnstone TB, Kanner R, Gee K. Pharmacological profile of a 17ß-heteroaryl-substituted neuroactive steroid. Psychopharmacology (Berl). 2014 Sep; 231(17):3517-24. PMID: 24682501.
      View in: PubMed
    5. Hogenkamp DJ, Ford-Hutchinson TA, Li WY, Whittemore ER, Yoshimura RF, Tran MB, Johnstone TB, Bascom GD, Rollins H, Lu L, Gee K. Design, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type I positive allosteric modulators of a7 nicotinic acetylcholine receptors. J Med Chem. 2013 Nov 14; 56(21):8352-65. PMID: 24098954; PMCID: PMC3912855.
    6. Yoshimura RF, Tran MB, Hogenkamp DJ, Johnstone TB, Xie JY, Porreca F, Gee K. Limited central side effects of a ß-subunit subtype-selective GABAA receptor allosteric modulator. J Psychopharmacol. 2014 May; 28(5):472-8. PMID: 24108410.
      View in: PubMed
    7. Loh AH, Gee K, Chua JH. Diagnostic accuracy of preoperative alpha-fetoprotein as an ovarian tumor marker in children and adolescents: not as good as we thought? Pediatr Surg Int. 2013 Jul; 29(7):709-13. PMID: 23653236.
      View in: PubMed
    8. Lotfipour S, Arnold MM, Hogenkamp DJ, Gee K, Belluzzi JD, Leslie FM. The monoamine oxidase (MAO) inhibitor tranylcypromine enhances nicotine self-administration in rats through a mechanism independent of MAO inhibition. Neuropharmacology. 2011 Jul-Aug; 61(1-2):95-104. PMID: 21419142; PMCID: PMC3105177.
    9. Johnstone TB, Gu Z, Yoshimura RF, Villegier AS, Hogenkamp DJ, Whittemore ER, Huang JC, Tran MB, Belluzzi JD, Yakel JL, Gee K. Allosteric modulation of related ligand-gated ion channels synergistically induces long-term potentiation in the hippocampus and enhances cognition. J Pharmacol Exp Ther. 2011 Mar; 336(3):908-15. PMID: 21159751; PMCID: PMC3061525.
    10. Gee K, Tran MB, Hogenkamp DJ, Johnstone TB, Bagnera RE, Yoshimura RF, Huang JC, Belluzzi JD, Whittemore ER. Limiting activity at beta1-subunit-containing GABAA receptor subtypes reduces ataxia. J Pharmacol Exp Ther. 2010 Mar; 332(3):1040-53. PMID: 19940102; PMCID: PMC2835428.
    11. Yoshimura RF, Hogenkamp DJ, Li WY, Tran MB, Belluzzi JD, Whittemore ER, Leslie FM, Gee K. Negative allosteric modulation of nicotinic acetylcholine receptors blocks nicotine self-administration in rats. J Pharmacol Exp Ther. 2007 Dec; 323(3):907-15. PMID: 17873105.
      View in: PubMed
    12. Hogenkamp DJ, Johnstone TB, Huang JC, Li WY, Tran M, Whittemore ER, Bagnera RE, Gee K. Enaminone amides as novel orally active GABAA receptor modulators. J Med Chem. 2007 Jul 12; 50(14):3369-79. PMID: 17571865.
      View in: PubMed
    13. Ng HJ, Whittemore ER, Tran MB, Hogenkamp DJ, Broide RS, Johnstone TB, Zheng L, Stevens KE, Gee K. Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. Proc Natl Acad Sci U S A. 2007 May 08; 104(19):8059-64. PMID: 17470817; PMCID: PMC1876571.
    14. Wang J, Hogenkamp DJ, Tran M, Li WY, Yoshimura RF, Johnstone TB, Shen WC, Gee K. Reversible lipidization for the oral delivery of leu-enkephalin. J Drug Target. 2006 Apr; 14(3):127-36. PMID: 16753826.
      View in: PubMed
    15. Johnstone TB, Hogenkamp DJ, Coyne L, Su J, Halliwell RF, Tran MB, Yoshimura RF, Li WY, Wang J, Gee K. Modifying quinolone antibiotics yields new anxiolytics. Nat Med. 2004 Jan; 10(1):31-2. PMID: 14647497.
      View in: PubMed
    16. Gee K. Academic entrepreneur--an oxymoron? Mol Interv. 2001 Oct; 1(4):186-8. PMID: 14993339.
      View in: PubMed
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