K A Manisha Samithri Perera

Title(s)Assistant Health Sciences Professor, Medicine
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
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    1. Rivaroxaban versus aspirin for prevention of covert brain infarcts in patients with embolic stroke of undetermined source: NAVIGATE ESUS MRI substudy. Int J Stroke. 2022 08; 17(7):799-805. Sharma M, Smith EE, Pearce LA, Perera KS, Kasner SE, Yoon BW, Ameriso SF, Puig J, Damgaard D, Fiebach JB, Muir KW, Veltkamp RC, Toni DS, Shamalov N, Gagliardi RJ, Mikulik R, Engelter ST, Bereczki D, O'Donnell MJ, Saad F, Shoamanesh A, Berkowitz SD, Mundl H, Hart RG, NAVIGATE ESUS MRI Substudy Investigators. PMID: 34791941; PMCID: PMC9358304.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    2. Frequency and Patterns of Brain Infarction in Patients With Embolic Stroke of Undetermined Source: NAVIGATE ESUS Trial. Stroke. 2022 01; 53(1):45-52. Sharma M, Smith EE, Pearce LA, Shoamanesh A, Perera KS, Coutts SB, Damgaard D, Ameriso SF, Rha JH, Modrau B, Yoon BW, Romano M, Messé SR, Barlinn J, Lambeck J, Saad F, Berkowitz SD, Mundl H, Connolly SJ, Hart RG, NAVIGATE ESUS MIND MRI Substudy Investigators. PMID: 34538089.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    3. Histopathologic analysis of retrieved cerebral thrombi in acute ischemic stroke patients with proximal anterior circulation occlusions amenable to endovascular thrombectomy. J Neurol Sci. 2021 10 15; 429:117617. Mak G, Lu JQ, Perera K. PMID: 34461551.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. Intracranial Atherosclerotic Plaque and Embolic Stroke of Undetermined Source: Another Piece of the Puzzle. J Am Coll Cardiol. 2021 02 16; 77(6):692-694. Hart RG, Perera KS. PMID: 33573738.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Statin treatment and cerebral microbleeds: A systematic review and meta-analysis. J Neurol Sci. 2021 01 15; 420:117224. Katsanos AH, Lioutas VA, Charidimou A, Catanese L, Ng KKH, Perera K, de Sa Boasquevisque D, Falcone GJ, Sheth KN, Romero JR, Tsivgoulis G, Smith EE, Sharma M, Selim MH, Shoamanesh A, International META-MICROBLEEDS Initiative. PMID: 33183779.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    6. Characteristics of Recurrent Ischemic Stroke After Embolic Stroke of Undetermined Source: Secondary Analysis of a Randomized Clinical Trial. JAMA Neurol. 2020 10 01; 77(10):1233-1240. Veltkamp R, Pearce LA, Korompoki E, Sharma M, Kasner SE, Toni D, Ameriso SF, Mundl H, Tatlisumak T, Hankey GJ, Lindgren A, Berkowitz SD, Arauz A, Ozturk S, Muir KW, Chamorro Á, Perera K, Shuaib A, Rudilosso S, Shoamanesh A, Connolly SJ, Hart RG. PMID: 32628266; PMCID: PMC7550970.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCTClinical Trials
    7. Novel Vascular Anastomoses and Moyamoya Disease in a Woman with Down Syndrome. Can J Neurol Sci. 2021 05; 48(3):417-418. Byworth MT, Moffatt JI, Perera KS. PMID: 32892767.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. In-Hospital Delays for Acute Stroke Treatment Delivery During the COVID-19 Pandemic. Can J Neurol Sci. 2021 Jan; 48(1):59-65. Katsanos AH, de Sa Boasquevisque D, Al-Qarni MA, Shawawrah M, McNicoll-Whiteman R, Gould L, Van Adel B, Sahlas DJ, Ng KKH, Perera K, Sharma M, Oczkowski W, Pikula A, Shoamanesh A, Catanese L. PMID: 32741386; PMCID: PMC7533482.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    9. Oral factor Xa inhibitors and risk of subdural hematoma: COMPASS trial results and meta-analysis. Neurology. 2020 08 04; 95(5):e480-e487. Catanese L, Eikelboom JW, Bosch J, Shestakovska O, Ng K, Nayar S, Perera KS, Shoamanesh A, Sharma M, Hart RG. PMID: 32651298.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Intracranial and systemic atherosclerosis in the NAVIGATE ESUS trial: Recurrent stroke risk and response to antithrombotic therapy. J Stroke Cerebrovasc Dis. 2020 Aug; 29(8):104936. Ameriso SF, Amarenco P, Pearce LA, Perera KS, Ntaios G, Lang W, Bereczki D, Uchiyama S, Kasner SE, Yoon BW, Lavados P, Firstenfeld A, Mikulik R, Povedano GP, Ferrari J, Mundl H, Berkowitz SD, Connolly SJ, Hart RG. PMID: 32689594.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    11. Statin treatment and accrual of covert cerebral ischaemia on neuroimaging: a systematic review and meta-analysis of randomized trials. Eur J Neurol. 2020 06; 27(6):1023-1027. Katsanos AH, Lioutas VA, Charidimou A, Catanese L, Ng KKH, Perera K, de Sa Boasquevisque D, Tsivgoulis G, Smith EE, Sharma M, Selim MH, Shoamanesh A. PMID: 32133735.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    12. Herpes Simplex Virus Type 2 Encephalitis Presenting as Multifocal Hemorrhagic Stroke. Can J Neurol Sci. 2020 07; 47(4):563-565. Mak G, Lu JQ, de Sa Boasquevisque D, Perera K. PMID: 32188516.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. Rivaroxaban versus aspirin for secondary prevention of ischaemic stroke in patients with cancer: a subgroup analysis of the NAVIGATE ESUS randomized trial. Eur J Neurol. 2020 05; 27(5):841-848. Martinez-Majander N, Ntaios G, Liu YY, Ylikotila P, Joensuu H, Saarinen J, Perera KS, Marti-Fabregas J, Chamorro A, Rudilosso S, Prats-Sanchez L, Berkowitz SD, Mundl H, Themeles E, Tiainen M, Demchuk A, Kasner SE, Hart RG, Tatlisumak T, NAVIGATE ESUS investigators. PMID: 32056346.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansPHPublic Health
    14. Atrial Cardiopathy and Nonstenosing Large Artery Plaque in Patients With Embolic Stroke of Undetermined Source. Stroke. 2020 03; 51(3):938-943. Kamel H, Pearce LA, Ntaios G, Gladstone DJ, Perera K, Roine RO, Meseguer E, Shoamanesh A, Berkowitz SD, Mundl H, Sharma M, Connolly SJ, Hart RG, Healey JS. PMID: 31893985; PMCID: PMC7042078.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    15. Association Between Low-Dose Rivaroxaban With or Without Aspirin and Ischemic Stroke Subtypes: A Secondary Analysis of the COMPASS Trial. JAMA Neurol. 2020 01 01; 77(1):43-48. Perera KS, Ng KKH, Nayar S, Catanese L, Dyal L, Sharma M, Connolly SJ, Yusuf S, Bosch J, Eikelboom JW, Hart RG. PMID: 31524941; PMCID: PMC6749537.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    16. Central Nervous System Involvement with Chronic Lymphocytic Leukemia. Can J Neurol Sci. 2019 09; 46(5):640-641. Witton LA, Menon S, Perera KS. PMID: 31120004.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Recurrent Stroke With Rivaroxaban Compared With Aspirin According to Predictors of Atrial Fibrillation: Secondary Analysis of the NAVIGATE ESUS Randomized Clinical Trial. JAMA Neurol. 2019 07 01; 76(7):764-773. Healey JS, Gladstone DJ, Swaminathan B, Eckstein J, Mundl H, Epstein AE, Haeusler KG, Mikulik R, Kasner SE, Toni D, Arauz A, Ntaios G, Hankey GJ, Perera K, Pagola J, Shuaib A, Lutsep H, Yang X, Uchiyama S, Endres M, Coutts SB, Karlinski M, Czlonkowska A, Molina CA, Santo G, Berkowitz SD, Hart RG, Connolly SJ. PMID: 30958508; PMCID: PMC6583060.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansPHPublic Health
    18. Predictors of Recurrent Ischemic Stroke in Patients with Embolic Strokes of Undetermined Source and Effects of Rivaroxaban Versus Aspirin According to Risk Status: The NAVIGATE ESUS Trial. J Stroke Cerebrovasc Dis. 2019 Aug; 28(8):2273-2279. Hart RG, Veltkamp RC, Sheridan P, Sharma M, Kasner SE, Bangdiwala SI, Ntaios G, Shoamanesh A, Ameriso SF, Toni D, Czlonkowska A, Lindgren A, Hankey GJ, Perera KS, Shuaib A, Coutts SB, Gagliardi RJ, Berkowitz SD, Mundl H, Peters G, Connolly SJ, NAVIGATE ESUS Investigators. PMID: 31160218.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    19. Myelitis with Hypoglycorrhachia due to Herpes Simplex Virus 2 in an Immunocompetent Man. Can J Neurol Sci. 2019 01; 46(1):147-148. Tomkinson C, Fong C, Perera K. PMID: 30458898.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    20. Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial. Lancet Neurol. 2018 12; 17(12):1053-1060. Kasner SE, Swaminathan B, Lavados P, Sharma M, Muir K, Veltkamp R, Ameriso SF, Endres M, Lutsep H, Messé SR, Spence JD, Nedeltechev K, Perera K, Santo G, Olavarria V, Lindgren A, Bangdiwala S, Shoamanesh A, Berkowitz SD, Mundl H, Connolly SJ, Hart RG, NAVIGATE ESUS Investigators. PMID: 30274772; PMCID: PMC6662613.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCTClinical Trials
    21. Stroke type and severity in patients with subclinical atrial fibrillation: An analysis from the Asymptomatic Atrial Fibrillation and Stroke Evaluation in Pacemaker Patients and the Atrial Fibrillation Reduction Atrial Pacing Trial (ASSERT). Am Heart J. 2018 07; 201:160-163. Perera KS, Sharma M, Connolly SJ, Wang J, Gold MR, Hohnloser SH, Lau CP, Van Gelder IC, Morillo C, Capucci A, Israel CW, Botto G, Healey JS. PMID: 29764671.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    22. Frequency and features of embolic stroke of undetermined source in young adults. Eur Stroke J. 2018 Jun; 3(2):110-116. Perera KS, Swaminathan B, Veltkamp R, Arauz A, Ameriso S, Marti-Fabregas J, Arnold M, Hankey GJ, Lutsep H, Hart RG. PMID: 31008343; PMCID: PMC6460410.
      View in: PubMed   Mentions: 7  
    23. Predictors of Mortality in Patients With Atrial Fibrillation (from the Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events [ACTIVE A]). Am J Cardiol. 2018 03 01; 121(5):584-589. Perera KS, Pearce LA, Sharma M, Benavente O, Connolly SJ, Hart RG, ACTIVE A (Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events) S. PMID: 29291887.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    24. Embolic Stroke of Undetermined Source: A Systematic Review and Clinical Update. Stroke. 2017 04; 48(4):867-872. Hart RG, Catanese L, Perera KS, Ntaios G, Connolly SJ. PMID: 28265016.
      View in: PubMed   Mentions: 149     Fields:    Translation:Humans
    25. Global Survey of the Frequency of Atrial Fibrillation-Associated Stroke: Embolic Stroke of Undetermined Source Global Registry. Stroke. 2016 09; 47(9):2197-202. Perera KS, Vanassche T, Bosch J, Swaminathan B, Mundl H, Giruparajah M, Barboza MA, O'Donnell MJ, Gomez-Schneider M, Hankey GJ, Yoon BW, Roxas A, Lavallee P, Sargento-Freitas J, Shamalov N, Brouns R, Gagliardi RJ, Kasner SE, Pieroni A, Vermehren P, Kitagawa K, Wang Y, Muir K, Coutinho JM, Connolly SJ, Hart RG, ESUS Global Registry Investigators. PMID: 27507860.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    26. Age disparity in diagnostic evaluation of stroke patients: Embolic Stroke of Undetermined Source Global Registry Project. Eur Stroke J. 2016 Jun; 1(2):130-138. Siegler JE, Swaminathan B, Giruparajah M, Bosch J, Perera KS, Hart RG, Kasner SE, ESUS Global Registry Investigators. PMID: 31008275; PMCID: PMC6301234.
      View in: PubMed   Mentions: 1  
    27. Embolic strokes of undetermined source: Prevalence and patient features in the ESUS Global Registry. Int J Stroke. 2016 07; 11(5):526-33. Perera KS, Vanassche T, Bosch J, Giruparajah M, Swaminathan B, Mattina KR, Berkowitz SD, Arauz A, O'Donnell MJ, Ameriso SF, Hankey GJ, Yoon BW, Lavallee P, Cunha L, Shamalov N, Brouns R, Gagliardi RJ, Kasner SE, Pieroni A, Vermehren P, Kitagawa K, Wang Y, Muir K, Coutinho J, Vastagh I, Connolly SJ, Hart RG, ESUS Global Registry Investigators. PMID: 27256472.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    28. What's new in stroke? Phase III randomized clinical trials of 2012-2014. Int J Stroke. 2015 Aug; 10(6):790-5. Hart RG, Ng KH, Perera KS, Shoamanesh A. PMID: 26178842.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    29. ACP Journal Club. In AF, apixaban reduced stroke or systemic embolism compared with warfarin, regardless of patient age. Ann Intern Med. 2014 Jun 17; 160(12):JC7. Sharma M, Perera K. PMID: 24935513.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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