Janos K Lanyi

Title(s)Professor Emeritus, Physiology and Biophysics
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-7150
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    Light-Driven Ion Transport in Bacterial Rhodopsins
    NIH R01GM029498Jul 1, 1981 - Aug 31, 2015
    Role: Principal Investigator
    NIH R37GM029498Jul 1, 1981 - Dec 30, 2010
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Light-driven Na(+) pump from Gillisia limnaea: a high-affinity Na(+) binding site is formed transiently in the photocycle. Biochemistry. 2014 Dec 09; 53(48):7549-61. Balashov SP, Imasheva ES, Dioumaev AK, Wang JM, Jung KH, Lanyi JK. PMID: 25375769.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    2. Directed evolution of a far-red fluorescent rhodopsin. Proc Natl Acad Sci U S A. 2014 Sep 09; 111(36):13034-9. McIsaac RS, Engqvist MK, Wannier T, Rosenthal AZ, Herwig L, Flytzanis NC, Imasheva ES, Lanyi JK, Balashov SP, Gradinaru V, Arnold FH. PMID: 25157169.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    3. Nature's toolkit for microbial rhodopsin ion pumps. Proc Natl Acad Sci U S A. 2014 May 06; 111(18):6538-9. Béjà O, Lanyi JK. PMID: 24737891.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    4. Photocycle of Exiguobacterium sibiricum rhodopsin characterized by low-temperature trapping in the IR and time-resolved studies in the visible. J Phys Chem B. 2013 Jun 20; 117(24):7235-53. Dioumaev AK, Petrovskaya LE, Wang JM, Balashov SP, Dolgikh DA, Kirpichnikov MP, Lanyi JK. PMID: 23718558.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    5. Breaking the carboxyl rule: lysine 96 facilitates reprotonation of the Schiff base in the photocycle of a retinal protein from Exiguobacterium sibiricum. J Biol Chem. 2013 Jul 19; 288(29):21254-21265. Balashov SP, Petrovskaya LE, Imasheva ES, Lukashev EP, Dioumaev AK, Wang JM, Sychev SV, Dolgikh DA, Rubin AB, Kirpichnikov MP, Lanyi JK. PMID: 23696649.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    6. Structure changes upon deprotonation of the proton release group in the bacteriorhodopsin photocycle. Biophys J. 2012 Aug 08; 103(3):444-452. Morgan JE, Vakkasoglu AS, Lanyi JK, Lugtenburg J, Gennis RB, Maeda A. PMID: 22947860.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    7. Molecular dynamics simulation of the unfolding of individual bacteriorhodopsin helices in sodium dodecyl sulfate micelles. Biochemistry. 2012 Feb 14; 51(6):1061-9. Krishnamani V, Lanyi JK. PMID: 22304411.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    8. Secondary and tertiary structure of bacteriorhodopsin in the SDS denatured state. Biochemistry. 2012 Feb 14; 51(6):1051-60. Krishnamani V, Hegde BG, Langen R, Lanyi JK. PMID: 22242919.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    9. Carotenoid response to retinal excitation and photoisomerization dynamics in xanthorhodopsin. Chem Phys Lett. 2011 Nov 07; 516(1-3):96-101. Slouf V, Balashov SP, Lanyi JK, Pullerits T, Polívka T. PMID: 22102759.
      View in: PubMed   Mentions:
    10. Structural changes in bacteriorhodopsin during in vitro refolding from a partially denatured state. Biophys J. 2011 Mar 16; 100(6):1559-67. Krishnamani V, Lanyi JK. PMID: 21402039.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    11. Removal and reconstitution of the carotenoid antenna of xanthorhodopsin. J Membr Biol. 2011 Jan; 239(1-2):95-104. Imasheva ES, Balashov SP, Wang JM, Lanyi JK. PMID: 21104180.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    12. Reconstitution of gloeobacter rhodopsin with echinenone: role of the 4-keto group. Biochemistry. 2010 Nov 16; 49(45):9792-9. Balashov SP, Imasheva ES, Choi AR, Jung KH, Liaaen-Jensen S, Lanyi JK. PMID: 20942439.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    13. Coordinating the structural rearrangements associated with unidirectional proton transfer in the bacteriorhodopsin photocycle induced by deprotonation of the proton-release group: a time-resolved difference FTIR spectroscopic study. Biochemistry. 2010 Apr 20; 49(15):3273-81. Morgan JE, Vakkasoglu AS, Lanyi JK, Gennis RB, Maeda A. PMID: 20232848.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    14. Low-temperature FTIR study of multiple K intermediates in the photocycles of bacteriorhodopsin and xanthorhodopsin. J Phys Chem B. 2010 Mar 04; 114(8):2920-31. Dioumaev AK, Wang JM, Lanyi JK. PMID: 20136108.
      View in: PubMed   Mentions: 2     Fields:    
    15. Two bathointermediates of the bacteriorhodopsin photocycle, from time-resolved nanosecond spectra in the visible. J Phys Chem B. 2009 Dec 31; 113(52):16643-53. Dioumaev AK, Lanyi JK. PMID: 19994879.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    16. Reconstitution of Gloeobacter violaceus rhodopsin with a light-harvesting carotenoid antenna. Biochemistry. 2009 Nov 24; 48(46):10948-55. Imasheva ES, Balashov SP, Choi AR, Jung KH, Lanyi JK. PMID: 19842712.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    17. Structural snapshots of conformational changes in a seven-helix membrane protein: lessons from bacteriorhodopsin. Curr Opin Struct Biol. 2009 Aug; 19(4):433-9. Hirai T, Subramaniam S, Lanyi JK. PMID: 19643594.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    18. Structural changes in the N and N' states of the bacteriorhodopsin photocycle. Biophys J. 2009 Apr 08; 96(7):2779-88. Chen D, Lanyi JK. PMID: 19348761.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    19. Femtosecond carotenoid to retinal energy transfer in xanthorhodopsin. Biophys J. 2009 Mar 18; 96(6):2268-77. Polívka T, Balashov SP, Chábera P, Imasheva ES, Yartsev A, Sundström V, Lanyi JK. PMID: 19289053.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    20. Infrared monitoring of interlayer water in stacks of purple membranes. Photochem Photobiol. 2009 Mar-Apr; 85(2):598-608. Dioumaev AK, Lanyi JK. PMID: 19192202.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    21. Crystallographic structure of xanthorhodopsin, the light-driven proton pump with a dual chromophore. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16561-5. Luecke H, Schobert B, Stagno J, Imasheva ES, Wang JM, Balashov SP, Lanyi JK. PMID: 18922772.
      View in: PubMed   Mentions: 63     Fields:    Translation:Cells
    22. Switch from conventional to distributed kinetics in the bacteriorhodopsin photocycle. Biochemistry. 2008 Oct 21; 47(42):11125-33. Dioumaev AK, Lanyi JK. PMID: 18821776.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    23. Excitation energy-transfer and the relative orientation of retinal and carotenoid in xanthorhodopsin. Biophys J. 2008 Sep; 95(5):2402-14. Balashov SP, Imasheva ES, Wang JM, Lanyi JK. PMID: 18515390.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    24. Xanthorhodopsin: a bacteriorhodopsin-like proton pump with a carotenoid antenna. Biochim Biophys Acta. 2008 Jul-Aug; 1777(7-8):684-8. Lanyi JK, Balashov SP. PMID: 18515067.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    25. Chromophore interaction in xanthorhodopsin--retinal dependence of salinixanthin binding. Photochem Photobiol. 2008 Jul-Aug; 84(4):977-84. Imasheva ES, Balashov SP, Wang JM, Smolensky E, Sheves M, Lanyi JK. PMID: 18399915.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    26. Withdrawn: Role of Lipids in Dynamic Phase Transition: FTIR Spectroscopy of Retinal-Protein Containing Membranes. Biophys J. 2007 Jul 13. Dioumaev AK, Lanyi JK. PMID: 17586573.
      View in: PubMed   Mentions:    Fields:    
    27. Bacteriorhodopsin photocycle at cryogenic temperatures reveals distributed barriers of conformational substates. Proc Natl Acad Sci U S A. 2007 Jun 05; 104(23):9621-6. Dioumaev AK, Lanyi JK. PMID: 17535910.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    28. Studies of the bacteriorhodopsin photocycle without the use of light: clues to proton transfer coupled reactions. J Mol Microbiol Biotechnol. 2007; 12(3-4):210-7. Lanyi JK. PMID: 17587869.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    29. Electron paramagnetic resonance study of structural changes in the O photointermediate of bacteriorhodopsin. J Mol Biol. 2007 Feb 23; 366(3):790-805. Chen D, Wang JM, Lanyi JK. PMID: 17196982.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    30. Structural changes in the L photointermediate of bacteriorhodopsin. J Mol Biol. 2007 Feb 02; 365(5):1379-92. Lanyi JK, Schobert B. PMID: 17141271.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    31. pH-dependent transitions in xanthorhodopsin. Photochem Photobiol. 2006 Nov-Dec; 82(6):1406-13. Imasheva ES, Balashov SP, Wang JM, Lanyi JK. PMID: 16649816.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    32. Propagating structural perturbation inside bacteriorhodopsin: crystal structures of the M state and the D96A and T46V mutants. Biochemistry. 2006 Oct 03; 45(39):12003-10. Lanyi JK, Schobert B. PMID: 17002299.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    33. Induced chirality of the light-harvesting carotenoid salinixanthin and its interaction with the retinal of xanthorhodopsin. Biochemistry. 2006 Sep 12; 45(36):10998-1004. Balashov SP, Imasheva ES, Lanyi JK. PMID: 16953586.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    34. Functions of carotenoids in xanthorhodopsin and archaerhodopsin, from action spectra of photoinhibition of cell respiration. Biochim Biophys Acta. 2006 Dec; 1757(12):1649-56. Boichenko VA, Wang JM, Antón J, Lanyi JK, Balashov SP. PMID: 17020745.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    35. A priori resolution of the intermediate spectra in the bacteriorhodopsin photocycle: the time evolution of the L spectrum revealed. J Phys Chem A. 2006 Feb 23; 110(7):2318-21. Zimányi L, Saltiel J, Brown LS, Lanyi JK. PMID: 16480288.
      View in: PubMed   Mentions: 8     Fields:    
    36. Proton transfers in the bacteriorhodopsin photocycle. Biochim Biophys Acta. 2006 Aug; 1757(8):1012-8. Lanyi JK. PMID: 16376293.
      View in: PubMed   Mentions: 63     Fields:    Translation:Cells
    37. Xanthorhodopsin: a proton pump with a light-harvesting carotenoid antenna. Science. 2005 Sep 23; 309(5743):2061-4. Balashov SP, Imasheva ES, Boichenko VA, Antón J, Wang JM, Lanyi JK. PMID: 16179480.
      View in: PubMed   Mentions: 87     Fields:    Translation:Cells
    38. Formation of a long-lived photoproduct with a deprotonated Schiff base in proteorhodopsin, and its enhancement by mutation of Asp227. Biochemistry. 2005 Aug 16; 44(32):10828-38. Imasheva ES, Shimono K, Balashov SP, Wang JM, Zadok U, Sheves M, Kamo N, Lanyi JK. PMID: 16086585.
      View in: PubMed   Mentions: 11     Fields:    
    39. Proton binding within a membrane protein by a protonated water cluster. Proc Natl Acad Sci U S A. 2005 Mar 08; 102(10):3633-8. Garczarek F, Brown LS, Lanyi JK, Gerwert K. PMID: 15738416.
      View in: PubMed   Mentions: 49     Fields:    Translation:Cells
    40. What is the real crystallographic structure of the L photointermediate of bacteriorhodopsin? Biochim Biophys Acta. 2004 Jul 23; 1658(1-2):14-22. Lanyi JK. PMID: 15282169.
      View in: PubMed   Mentions: 8     Fields:    
    41. X-ray diffraction of bacteriorhodopsin photocycle intermediates. Mol Membr Biol. 2004 May-Jun; 21(3):143-50. Lanyi JK. PMID: 15204622.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    42. The nitrate transporting photochemical reaction cycle of the pharaonis halorhodopsin. Biophys J. 2004 Mar; 86(3):1655-63. Bálint Z, Lakatos M, Ganea C, Lanyi JK, Váró G. PMID: 14990493.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    43. Selectivity of retinal photoisomerization in proteorhodopsin is controlled by aspartic acid 227. Biochemistry. 2004 Feb 17; 43(6):1648-55. Imasheva ES, Balashov SP, Wang JM, Dioumaev AK, Lanyi JK. PMID: 14769042.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    44. Local-global conformational coupling in a heptahelical membrane protein: transport mechanism from crystal structures of the nine states in the bacteriorhodopsin photocycle. Biochemistry. 2004 Jan 13; 43(1):3-8. Lanyi JK, Schobert B. PMID: 14705925.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    45. Bacteriorhodopsin. Annu Rev Physiol. 2004; 66:665-88. Lanyi JK. PMID: 14977418.
      View in: PubMed   Mentions: 135     Fields:    Translation:Cells
    46. Crystallographic structures of the M and N intermediates of bacteriorhodopsin: assembly of a hydrogen-bonded chain of water molecules between Asp-96 and the retinal Schiff base. J Mol Biol. 2003 Jul 11; 330(3):553-70. Schobert B, Brown LS, Lanyi JK. PMID: 12842471.
      View in: PubMed   Mentions: 43     Fields:    Translation:Cells
    47. Proton transport by proteorhodopsin requires that the retinal Schiff base counterion Asp-97 be anionic. Biochemistry. 2003 Jun 03; 42(21):6582-7. Dioumaev AK, Wang JM, Bálint Z, Váró G, Lanyi JK. PMID: 12767242.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    48. The photochemical reaction cycle of proteorhodopsin at low pH. Biophys J. 2003 May; 84(5):3252-6. Lakatos M, Lanyi JK, Szakács J, Váró G. PMID: 12719254.
      View in: PubMed   Mentions: 15     Fields:    
    49. Mechanism of proton transport in bacteriorhodopsin from crystallographic structures of the K, L, M1, M2, and M2' intermediates of the photocycle. J Mol Biol. 2003 Apr 25; 328(2):439-50. Lanyi JK, Schobert B. PMID: 12691752.
      View in: PubMed   Mentions: 42     Fields:    Translation:Cells
    50. Characterization of the photochemical reaction cycle of proteorhodopsin. Biophys J. 2003 Feb; 84(2 Pt 1):1202-7. Váró G, Brown LS, Lakatos M, Lanyi JK. PMID: 12547799.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    51. Structural clues to the mechanism of ion pumping in bacteriorhodopsin. Adv Protein Chem. 2003; 63:111-30. Luecke H, Lanyi JK. PMID: 12629968.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    52. Crystallographic structure of the K intermediate of bacteriorhodopsin: conservation of free energy after photoisomerization of the retinal. J Mol Biol. 2002 Aug 23; 321(4):715-26. Schobert B, Cupp-Vickery J, Hornak V, Smith S, Lanyi J. PMID: 12206785.
      View in: PubMed   Mentions: 48     Fields:    Translation:Cells
    53. Crystallographic structure of the retinal and the protein after deprotonation of the Schiff base: the switch in the bacteriorhodopsin photocycle. J Mol Biol. 2002 Aug 23; 321(4):727-37. Lanyi J, Schobert B. PMID: 12206786.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    54. Changes in hydrogen bonding and environment of tryptophan residues on helix F of bacteriorhodopsin during the photocycle: a time-resolved ultraviolet resonance Raman study. Biochemistry. 2002 May 21; 41(20):6495-503. Hashimoto S, Sasaki M, Takeuchi H, Needleman R, Lanyi JK. PMID: 12009913.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    55. Proton transfers in the photochemical reaction cycle of proteorhodopsin. Biochemistry. 2002 Apr 30; 41(17):5348-58. Dioumaev AK, Brown LS, Shih J, Spudich EN, Spudich JL, Lanyi JK. PMID: 11969395.
      View in: PubMed   Mentions: 55     Fields:    Translation:Cells
    56. Characterization of the azide-dependent bacteriorhodopsin-like photocycle of salinarum halorhodopsin. Biophys J. 2002 Apr; 82(4):1687-95. Lakatos M, Groma GI, Ganea C, Lanyi JK, Váró G. PMID: 11916830.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    57. Conformational change of the E-F interhelical loop in the M photointermediate of bacteriorhodopsin. J Mol Biol. 2002 Mar 29; 317(3):471-8. Brown LS, Needleman R, Lanyi JK. PMID: 11922678.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
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