James S Nowick

Title(s)Professor, Pharmaceutical Sciences
SchoolSchool of Pharmacy and Pharmaceutical Sciences
Address101 Theory, Suite 100
Irvine CA 92697-3958
Phone(949) 824-6091
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    Collapse Research 
    Collapse Research Activities and Funding
    Structural and Biological Characterization of Diverse Oligomers Derived from Abeta
    NIH RF1AG072587May 1, 2021 - Apr 30, 2024
    Role: Principal Investigator
    Amyloidogenic Antibiotics
    NIH R21AI156565Nov 20, 2020 - Oct 31, 2022
    Role: Principal Investigator
    Antibodies Against Conformationally Defined Amyloid Oligomers in Alzheimer?s Disease
    NIH RF1AG062296Sep 30, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Development of Teixobactin Analogues
    NIH R56AI137258Aug 21, 2018 - Jul 31, 2021
    Role: Principal Investigator
    Synthesis and Studies of a New Family of Antibiotics
    NIH R21AI121548Mar 1, 2016 - Feb 28, 2019
    Role: Principal Investigator
    Mimicry of Amyloid Oligomers
    NIH R01GM097562Feb 1, 2012 - Jan 31, 2021
    Role: Principal Investigator
    Chemical Models of Protein beta-Sheet Interactions
    NIH R01GM049076Apr 1, 1994 - Nov 30, 2010
    Role: Principal Investigator
    NEW STRATEGIES FOR FORMATION OF PEPTIDE BETA-SHEETS
    NIH R29GM049076Apr 1, 1994 - Mar 31, 1999
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Elucidating the Oligomerization and Cellular Interactions of a Trimer Derived from Aβ through Fluorescence and Mass Spectrometric Studies. ACS Chem Neurosci. 2022 Aug 17; 13(16):2473-2482. Guaglianone G, Torrado B, Lin YF, Watkins MC, Wysocki VH, Gratton E, Nowick JS. PMID: 35892278.
      View in: PubMed   Mentions:    Fields:    
    2. Enantiomeric β-sheet peptides from Aβ form homochiral pleated β-sheets rather than heterochiral rippled β-sheets. Chem Sci. 2022 Jul 06; 13(26):7739-7746. Li X, Rios SE, Nowick JS. PMID: 35865901; PMCID: PMC9258340.
      View in: PubMed   Mentions:
    3. Visualizing the mode of action and supramolecular assembly of teixobactin analogues in Bacillus subtilis. Chem Sci. 2022 Jul 06; 13(26):7747-7754. Morris MA, Vallmitjana A, Grein F, Schneider T, Arts M, Jones CR, Nguyen BT, Hashemian MH, Malek M, Gratton E, Nowick JS. PMID: 35865902; PMCID: PMC9258396.
      View in: PubMed   Mentions:
    4. Editorial. Eur J Med Chem. 2022 06 05; 236:114340. Moitessier N, Nowick J. PMID: 35405398; PMCID: PMC8970607.
      View in: PubMed   Mentions:    Fields:    
    5. Effects of Familial Alzheimer's Disease Mutations on the Assembly of a β-Hairpin Peptide Derived from Aβ16-36. Biochemistry. 2022 03 15; 61(6):446-454. McKnelly KJ, Kreutzer AG, Howitz WJ, Haduong K, Yoo S, Hart C, Nowick JS. PMID: 35213141; PMCID: PMC9042424.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    6. Macrocyclic Peptides Derived from Familial Alzheimer's Disease Mutants Show Charge-Dependent Oligomeric Assembly and Toxicity. ACS Chem Neurosci. 2022 03 16; 13(6):714-720. Howitz WJ, Guaglianone G, McKnelly KJ, Haduong K, Ashby SN, Laayouni M, Nowick JS. PMID: 35191689; PMCID: PMC9042422.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. A Disulfide-Stabilized Aβ that Forms Dimers but Does Not Form Fibrils. Biochemistry. 2022 02 15; 61(4):252-264. Zhang S, Yoo S, Snyder DT, Katz BB, Henrickson A, Demeler B, Wysocki VH, Kreutzer AG, Nowick JS. PMID: 35080857; PMCID: PMC9083094.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Synthesis and application of fluorescent teixobactin analogs. Methods Enzymol. 2022; 665:233-258. Morris MA, Jones CR, Nowick JS. PMID: 35379436; PMCID: PMC9109785.
      View in: PubMed   Mentions:    Fields:    
    9. Editorial overview: Amyloid-inspired synthetic biomolecules. Curr Opin Chem Biol. 2021 10; 64:A3-A6. Petersson EJ, Nowick JS. PMID: 34656424.
      View in: PubMed   Mentions:    Fields:    
    10. Visualizing Teixobactin Supramolecular Assemblies and Cell Wall Damage in B. Subtilis Using CryoEM. ACS Omega. 2021 Oct 19; 6(41):27412-27417. Hurst PJ, Morris MA, Graham AA, Nowick JS, Patterson JP. PMID: 34693162; PMCID: PMC8529686.
      View in: PubMed   Mentions: 1  
    11. An Improved Turn Structure for Inducing β-Hairpin Formation in Peptides. Angew Chem Int Ed Engl. 2021 10 11; 60(42):22776-22782. Li X, Sabol AL, Wierzbicki M, Salveson PJ, Nowick JS. PMID: 34258835; PMCID: PMC8490300.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    12. Exploring amyloid oligomers with peptide model systems. Curr Opin Chem Biol. 2021 10; 64:106-115. Samdin TD, Kreutzer AG, Nowick JS. PMID: 34229162; PMCID: PMC9042423.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    13. Correction to "Expression of N-Terminal Cysteine Aβ42 and Conjugation to Generate Fluorescent and Biotinylated Aβ42". Biochemistry. 2021 Jul 20; 60(28):2272-2273. Zhang S, Guaglianone G, Morris MA, Yoo S, Howitz WJ, Xing L, Zheng JG, Jusuf H, Huizar G, Lin J, Kreutzer AG, Nowick JS. PMID: 34213906.
      View in: PubMed   Mentions:    Fields:    
    14. Synthesis and study of macrocyclic β-hairpin peptides for investigating amyloid oligomers. Methods Enzymol. 2021; 656:123-168. Guaglianone G, Kreutzer AG, Nowick JS. PMID: 34325785; PMCID: PMC9053554.
      View in: PubMed   Mentions:    Fields:    
    15. A cyclic peptide inhibitor of the SARS-CoV-2 main protease. Eur J Med Chem. 2021 Oct 05; 221:113530. Kreutzer AG, Krumberger M, Diessner EM, Parrocha CMT, Morris MA, Guaglianone G, Butts CT, Nowick JS. PMID: 34023738; PMCID: PMC8096527.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    16. Expression of N-Terminal Cysteine Aβ42 and Conjugation to Generate Fluorescent and Biotinylated Aβ42. Biochemistry. 2021 04 20; 60(15):1191-1200. Zhang S, Guaglianone G, Morris MA, Yoo S, Howitz WJ, Xing L, Zheng JG, Jusuf H, Huizar G, Lin J, Kreutzer AG, Nowick JS. PMID: 33793198; PMCID: PMC9059633.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    17. Structure-based drug design of an inhibitor of the SARS-CoV-2 (COVID-19) main protease using free software: A tutorial for students and scientists. Eur J Med Chem. 2021 Jun 05; 218:113390. Zhang S, Krumberger M, Morris MA, Parrocha CMT, Kreutzer AG, Nowick JS. PMID: 33812315; PMCID: PMC7980496.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    18. Phenylalanine Mutation to Cyclohexylalanine Facilitates Triangular Trimer Formation by β-Hairpins Derived from Aβ. J Am Chem Soc. 2020 12 09; 142(49):20708-20716. Haerianardakani S, Kreutzer AG, Salveson PJ, Samdin TD, Guaglianone GE, Nowick JS. PMID: 33237748; PMCID: PMC7821965.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    19. Correction to "Interpenetrating Cubes in the X-ray Crystallographic Structure of a Peptide Derived from Medin19-36". J Am Chem Soc. 2020 Nov 04; 142(44):18998. Howitz WJ, Wierzbicki M, Cabanela RW, Saliba C, Motavalli A, Tran N, Nowick JS. PMID: 33086010.
      View in: PubMed   Mentions:    Fields:    
    20. Interpenetrating Cubes in the X-ray Crystallographic Structure of a Peptide Derived from Medin19-36. J Am Chem Soc. 2020 09 16; 142(37):15870-15875. Howitz WJ, Wierzbicki M, Cabanela RW, Saliba C, Motavalli A, Tran N, Nowick JS. PMID: 32816461; PMCID: PMC7819122.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    21. Structure-Based Drug Design of an Inhibitor of the SARS-CoV-2 (COVID-19) Main Protease Using Free Software: A Tutorial for Students and Scientists. ChemRxiv. 2020 Aug 12. Zhang S, Krumberger M, Morris MA, Parrocha CMT, Griffin JH, Kreutzer AG, Nowick JS. PMID: 32817929; PMCID: PMC7430054.
      View in: PubMed   Mentions:
    22. X-ray Crystallography Reveals Parallel and Antiparallel β-Sheet Dimers of a β-Hairpin Derived from Aβ16-36 that Assemble to Form Different Tetramers. ACS Chem Neurosci. 2020 08 05; 11(15):2340-2347. Kreutzer AG, Samdin TD, Guaglianone G, Spencer RK, Nowick JS. PMID: 32584538; PMCID: PMC7811405.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    23. Effects of N-Terminal Residues on the Assembly of Constrained β-Hairpin Peptides Derived from Aβ. J Am Chem Soc. 2020 07 01; 142(26):11593-11601. Samdin TD, Wierzbicki M, Kreutzer AG, Howitz WJ, Valenzuela M, Smith A, Sahrai V, Truex NL, Klun M, Nowick JS. PMID: 32501687; PMCID: PMC7927569.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    24. A Fluorescent Teixobactin Analogue. ACS Chem Biol. 2020 05 15; 15(5):1222-1231. Morris MA, Malek M, Hashemian MH, Nguyen BT, Manuse S, Lewis K, Nowick JS. PMID: 32045203; PMCID: PMC7814985.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    25. Anaphylaxis Induced by Peptide Coupling Agents: Lessons Learned from Repeated Exposure to HATU, HBTU, and HCTU. J Org Chem. 2020 02 07; 85(3):1764-1768. McKnelly KJ, Sokol W, Nowick JS. PMID: 31849224.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    26. Structural Interaction of Apolipoprotein A-I Mimetic Peptide with Amyloid-β Generates Toxic Hetero-oligomers. J Mol Biol. 2020 02 14; 432(4):1020-1034. Sahoo BR, Bekier ME, Liu Z, Kocman V, Stoddard AK, Anantharamaiah GM, Nowick J, Fierke CA, Wang Y, Ramamoorthy A. PMID: 31866295; PMCID: PMC7054163.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    27. Design, Synthesis, and Study of Lactam and Ring-Expanded Analogues of Teixobactin. J Org Chem. 2020 02 07; 85(3):1331-1339. Yang H, Pishenko AV, Li X, Nowick JS. PMID: 31746604; PMCID: PMC7814697.
      View in: PubMed   Mentions: 2     Fields:    
    28. Structure-Based Peptide Inhibitor Design of Amyloid-β Aggregation. Front Mol Neurosci. 2019; 12:54. Lu J, Cao Q, Wang C, Zheng J, Luo F, Xie J, Li Y, Ma X, He L, Eisenberg D, Nowick J, Jiang L, Li D. PMID: 30886570; PMCID: PMC6409328.
      View in: PubMed   Mentions: 18  
    29. Structural Polymorphs Suggest Competing Pathways for the Formation of Amyloid Fibrils That Diverge from a Common Intermediate Species. Biochemistry. 2018 11 20; 57(46):6470-6478. Buchanan LE, Maj M, Dunkelberger EB, Cheng PN, Nowick JS, Zanni MT. PMID: 30375231; PMCID: PMC6368979.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    30. Correction to "Repurposing Triphenylmethane Dyes To Bind to Trimers Derived from Aβ". J Am Chem Soc. 2018 Nov 14; 140(45):15546. Salveson PJ, Haerianardakani S, Thuy-Boun A, Yoo S, Kreutzer AG, Demeler B, Nowick JS. PMID: 30394740.
      View in: PubMed   Mentions:    Fields:    
    31. X-ray Crystallographic Structure of a Teixobactin Derivative Reveals Amyloid-like Assembly. J Am Chem Soc. 2018 10 31; 140(43):14028-14032. Yang H, Wierzbicki M, Du Bois DR, Nowick JS. PMID: 30296063; PMCID: PMC6356018.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    32. Repurposing Triphenylmethane Dyes to Bind to Trimers Derived from Aβ. J Am Chem Soc. 2018 09 19; 140(37):11745-11754. Salveson PJ, Haerianardakani S, Thuy-Boun A, Yoo S, Kreutzer AG, Demeler B, Nowick JS. PMID: 30125493; PMCID: PMC6339561.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    33. An Efficient Method for the Expression and Purification of Aβ(M1-42). Biochemistry. 2018 07 03; 57(26):3861-3866. Yoo S, Zhang S, Kreutzer AG, Nowick JS. PMID: 29757632; PMCID: PMC6320699.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    34. Controlling the Oligomerization State of Aβ-Derived Peptides with Light. J Am Chem Soc. 2018 05 02; 140(17):5842-5852. Salveson PJ, Haerianardakani S, Thuy-Boun A, Kreutzer AG, Nowick JS. PMID: 29627987; PMCID: PMC6361387.
      View in: PubMed   Mentions: 9     Fields:    
    35. Elucidating the Structures of Amyloid Oligomers with Macrocyclic β-Hairpin Peptides: Insights into Alzheimer's Disease and Other Amyloid Diseases. Acc Chem Res. 2018 03 20; 51(3):706-718. Kreutzer AG, Nowick JS. PMID: 29508987; PMCID: PMC5911177.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    36. A Hexamer of a Peptide Derived from Aβ16-36. Biochemistry. 2017 11 14; 56(45):6061-6071. Kreutzer AG, Spencer RK, McKnelly KJ, Yoo S, Hamza IL, Salveson PJ, Nowick JS. PMID: 29028351; PMCID: PMC5689071.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    37. Alanine scan reveals modifiable residues in teixobactin. Chem Commun (Camb). 2017 Oct 12; 53(82):11357-11359. Chen KH, Le SP, Han X, Frias JM, Nowick JS. PMID: 28967925; PMCID: PMC6361391.
      View in: PubMed   Mentions: 10     Fields:    
    38. Effects of charge and hydrophobicity on the oligomerization of peptides derived from IAPP. Bioorg Med Chem. 2018 03 15; 26(6):1151-1156. Wang Y, Truex NL, Vo NDP, Nowick JS. PMID: 29074350.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    39. Transmembrane Proteins: Amyloids Hidden in Plain Sight? Biochemistry. 2017 09 12; 56(36):4735-4736. Truex NL, Nowick JS. PMID: 28853555; PMCID: PMC7556710.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    40. A Tetramer Derived from Islet Amyloid Polypeptide. J Org Chem. 2017 08 04; 82(15):7905-7912. Wang Y, Kreutzer AG, Truex NL, Nowick JS. PMID: 28661686; PMCID: PMC7532939.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    41. X-ray Crystallographic Structure of a Compact Dodecamer from a Peptide Derived from Aβ16-36. Org Lett. 2017 07 07; 19(13):3462-3465. Salveson PJ, Spencer RK, Kreutzer AG, Nowick JS. PMID: 28683555; PMCID: PMC5776032.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    42. X-ray Crystallographic Structure of a Giant Double-Walled Peptide Nanotube Formed by a Macrocyclic β-Sheet Containing Aβ16-22. J Am Chem Soc. 2017 06 21; 139(24):8102-8105. Chen KH, Corro KA, Le SP, Nowick JS. PMID: 28598147.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    43. X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore. Chem Commun (Camb). 2017 Feb 28; 53(18):2772-2775. Yang H, Du Bois DR, Ziller JW, Nowick JS. PMID: 28217800; PMCID: PMC5381722.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    44. Stabilization, Assembly, and Toxicity of Trimers Derived from Aβ. J Am Chem Soc. 2017 01 18; 139(2):966-975. Kreutzer AG, Yoo S, Spencer RK, Nowick JS. PMID: 28001392; PMCID: PMC5256483.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    45. Assembly of Peptides Derived from β-Sheet Regions of β-Amyloid. J Am Chem Soc. 2016 10 26; 138(42):13882-13890. Truex NL, Wang Y, Nowick JS. PMID: 27642651; PMCID: PMC5089065.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    46. Coassembly of Peptides Derived from β-Sheet Regions of β-Amyloid. J Am Chem Soc. 2016 10 26; 138(42):13891-13900. Truex NL, Nowick JS. PMID: 27642763; PMCID: PMC5089069.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    47. Square channels formed by a peptide derived from transthyretin. Chem Sci. 2016 Dec 01; 7(12):6946-6951. Yoo S, Kreutzer AG, Truex NL, Nowick JS. PMID: 28451128; PMCID: PMC5355858.
      View in: PubMed   Mentions: 5  
    48. Elucidation of the Teixobactin Pharmacophore. ACS Chem Biol. 2016 07 15; 11(7):1823-6. Yang H, Chen KH, Nowick JS. PMID: 27232661; PMCID: PMC5283680.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    49. X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an Aβ17-36 β-Hairpin. J Am Chem Soc. 2016 Apr 06; 138(13):4634-42. Kreutzer AG, Hamza IL, Spencer RK, Nowick JS. PMID: 26967810; PMCID: PMC4831588.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    50. X-ray Crystallographic Structure of Oligomers Formed by a Toxic β-Hairpin Derived from α-Synuclein: Trimers and Higher-Order Oligomers. J Am Chem Soc. 2016 Apr 06; 138(13):4458-67. Salveson PJ, Spencer RK, Nowick JS. PMID: 26926877; PMCID: PMC4825732.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    51. Diversification of β-Augmentation Interactions between CDI Toxin/Immunity Proteins. J Mol Biol. 2015 Nov 20; 427(23):3766-84. Morse RP, Willett JL, Johnson PM, Zheng J, Credali A, Iniguez A, Nowick JS, Hayes CS, Goulding CW. PMID: 26449640; PMCID: PMC4658667.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    52. A Newcomer's Guide to Peptide Crystallography. Isr J Chem. 2015 Jun 01; 55(6-7):698-710. Spencer RK, Nowick JS. PMID: 26213415; PMCID: PMC4508863.
      View in: PubMed   Mentions: 13  
    53. X-ray Crystallographic Structures of Oligomers of Peptides Derived from β2-Microglobulin. J Am Chem Soc. 2015 May 20; 137(19):6304-11. Spencer RK, Kreutzer AG, Salveson PJ, Li H, Nowick JS. PMID: 25915729; PMCID: PMC4523215.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    54. A fibril-like assembly of oligomers of a peptide derived from β-amyloid. J Am Chem Soc. 2014 Sep 10; 136(36):12682-90. Pham JD, Spencer RK, Chen KH, Nowick JS. PMID: 25068693; PMCID: PMC4183627.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    55. X-ray crystallographic structures of trimers and higher-order oligomeric assemblies of a peptide derived from Aβ(17-36). J Am Chem Soc. 2014 Apr 16; 136(15):5595-8. Spencer RK, Li H, Nowick JS. PMID: 24669800; PMCID: PMC4004244.
      View in: PubMed   Mentions: 47     Fields:    Translation:Cells
    56. Polymorphism of oligomers of a peptide from β-amyloid. J Am Chem Soc. 2014 Apr 09; 136(14):5432-42. Pham JD, Demeler B, Nowick JS. PMID: 24669785; PMCID: PMC4004211.
      View in: PubMed   Mentions: 14     Fields:    
    57. Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient β-sheet. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19285-90. Buchanan LE, Dunkelberger EB, Tran HQ, Cheng PN, Chiu CC, Cao P, Raleigh DP, de Pablo JJ, Nowick JS, Zanni MT. PMID: 24218609; PMCID: PMC3845187.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    58. Structures of oligomers of a peptide from β-amyloid. J Am Chem Soc. 2013 Aug 21; 135(33):12460-7. Pham JD, Chim N, Goulding CW, Nowick JS. PMID: 23927812; PMCID: PMC3787202.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    59. A hydrophobic surface is essential to inhibit the aggregation of a tau-protein-derived hexapeptide. J Am Chem Soc. 2013 May 08; 135(18):6846-52. Zheng J, Baghkhanian AM, Nowick JS. PMID: 23627648.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    60. The supramolecular chemistry of β-sheets. J Am Chem Soc. 2013 Apr 17; 135(15):5477-92. Cheng PN, Pham JD, Nowick JS. PMID: 23548073; PMCID: PMC3642101.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    61. Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Proc Natl Acad Sci U S A. 2012 Dec 18; 109(51):20913-8. Liu C, Zhao M, Jiang L, Cheng PN, Park J, Sawaya MR, Pensalfini A, Gou D, Berk AJ, Glabe CG, Nowick J, Eisenberg D. PMID: 23213214; PMCID: PMC3529048.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansCells
    62. Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity. Nat Chem. 2012 Nov; 4(11):927-33. Cheng PN, Liu C, Zhao M, Eisenberg D, Nowick JS. PMID: 23089868; PMCID: PMC3481199.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    63. Heterodivalent linked macrocyclic β-sheets with enhanced activity against Aβ aggregation: two sites are better than one. J Am Chem Soc. 2012 Aug 29; 134(34):14179-84. Cheng PN, Spencer R, Woods RJ, Glabe CG, Nowick JS. PMID: 22827298; PMCID: PMC3430741.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    64. Giant macrolactams based on β-sheet peptides. J Org Chem. 2011 May 06; 76(9):3166-73. Cheng PN, Nowick JS. PMID: 21452877; PMCID: PMC3088102.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    65. Characteristics of amyloid-related oligomers revealed by crystal structures of macrocyclic β-sheet mimics. J Am Chem Soc. 2011 May 04; 133(17):6736-44. Liu C, Sawaya MR, Cheng PN, Zheng J, Nowick JS, Eisenberg D. PMID: 21473620; PMCID: PMC3124511.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    66. Macrocyclic β-sheet peptides that inhibit the aggregation of a tau-protein-derived hexapeptide. J Am Chem Soc. 2011 Mar 09; 133(9):3144-57. Zheng J, Liu C, Sawaya MR, Vadla B, Khan S, Woods RJ, Eisenberg D, Goux WJ, Nowick JS. PMID: 21319744; PMCID: PMC3048834.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    67. X-ray crystallographic structure of an artificial beta-sheet dimer. J Am Chem Soc. 2010 Aug 25; 132(33):11622-8. Khakshoor O, Lin AJ, Korman TP, Sawaya MR, Tsai SC, Eisenberg D, Nowick JS. PMID: 20669960; PMCID: PMC2929266.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    68. Nanometer-scale water-soluble macrocycles from nanometer-sized amino acids. J Org Chem. 2010 Mar 19; 75(6):1822-30. Gothard CM, Nowick JS. PMID: 20020731; PMCID: PMC2837776.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    69. Selective heteronuclear Hartmann-Hahn: a multiple-pulse sequence for selective magnetization transfer in the structural elucidation of "isotagged" oligosaccharides. J Magn Reson. 2010 Mar; 203(1):73-80. Meng X, Nguyen WH, Nowick JS, Shaka AJ. PMID: 20044287.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    70. Use of disulfide "staples" to stabilize beta-sheet quaternary structure. Org Lett. 2009 Jul 16; 11(14):3000-3. Khakshoor O, Nowick JS. PMID: 19534505; PMCID: PMC2726807.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    71. A new artificial beta-sheet that dimerizes through parallel beta-sheet interactions. Org Lett. 2009 Feb 19; 11(4):1003-6. Levin S, Nowick JS. PMID: 19173616; PMCID: PMC2652689.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    72. Functionalized analogues of an unnatural amino acid that mimics a tripeptide beta-strand. Org Lett. 2008 Nov 20; 10(22):5293-6. Khasanova TV, Khakshoor O, Nowick JS. PMID: 18937484; PMCID: PMC2659333.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    73. Exploring beta-sheet structure and interactions with chemical model systems. Acc Chem Res. 2008 Oct; 41(10):1319-30. Nowick JS. PMID: 18798654; PMCID: PMC2728010.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    74. Artificial beta-sheets: chemical models of beta-sheets. Curr Opin Chem Biol. 2008 Dec; 12(6):722-9. Khakshoor O, Nowick JS. PMID: 18775794; PMCID: PMC2646360.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    75. An artificial beta-sheet that dimerizes through parallel beta-sheet interactions. J Am Chem Soc. 2007 Oct 31; 129(43):13043-8. Levin S, Nowick JS. PMID: 17918935; PMCID: PMC2593858.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    76. Nanometer-sized amino acids for the synthesis of nanometer-scale water-soluble molecular rods of precise length. J Am Chem Soc. 2007 Jun 13; 129(23):7272-3. Gothard CM, Rao NA, Nowick JS. PMID: 17503829; PMCID: PMC2552997.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    77. Macrocyclic beta-sheet peptides that mimic protein quaternary structure through intermolecular beta-sheet interactions. J Am Chem Soc. 2007 May 02; 129(17):5558-69. Khakshoor O, Demeler B, Nowick JS. PMID: 17419629; PMCID: PMC2596933.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    78. Cyclic modular beta-sheets. J Am Chem Soc. 2007 Mar 07; 129(9):2548-58. Woods RJ, Brower JO, Castellanos E, Hashemzadeh M, Khakshoor O, Russu WA, Nowick JS. PMID: 17295482; PMCID: PMC2597679.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    79. A new class of macrocyclic receptors from iota-peptides. J Am Chem Soc. 2007 Feb 14; 129(6):1486-7. Kang SW, Gothard CM, Maitra S, Nowick JS. PMID: 17243690.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    80. What I have learned by using chemical model systems to study biomolecular structure and interactions. Org Biomol Chem. 2006 Nov 07; 4(21):3869-85. Nowick JS. PMID: 17047863.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    81. The absence of favorable aromatic interactions between beta-sheet peptides. J Am Chem Soc. 2005 Jul 20; 127(28):9998-9. Chung DM, Dou Y, Baldi P, Nowick JS. PMID: 16011353.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    82. ICBS: a database of interactions between protein chains mediated by beta-sheet formation. Bioinformatics. 2004 Nov 01; 20(16):2767-77. Dou Y, Baisnée PF, Pollastri G, Pécout Y, Nowick J, Baldi P. PMID: 15166020.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    83. Enantioselective molecular recognition between beta-sheets. J Am Chem Soc. 2004 Mar 17; 126(10):3062-3. Chung DM, Nowick JS. PMID: 15012131.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    84. DSA: a new internal standard for NMR studies in aqueous solution. Org Lett. 2003 Sep 18; 5(19):3511-3. Nowick JS, Khakshoor O, Hashemzadeh M, Brower JO. PMID: 12967312.
      View in: PubMed   Mentions: 18     Fields:    
    85. Sequence-selective molecular recognition between beta sheets. Angew Chem Int Ed Engl. 2003 Apr 17; 42(15):1765-8. Nowick JS, Chung DM. PMID: 12707901.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    86. Dityrosine cross-linked Abeta peptides: fibrillar beta-structure in Abeta(1-40) is conducive to formation of dityrosine cross-links but a dityrosine cross-link in Abeta(8-14) does not induce beta-structure. Chem Res Toxicol. 2003 Apr; 16(4):531-5. Yoburn JC, Tian W, Brower JO, Nowick JS, Glabe CG, Van Vranken DL. PMID: 12703970.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    87. A new turn structure for the formation of beta-hairpins in peptides. J Am Chem Soc. 2003 Jan 29; 125(4):876-7. Nowick JS, Brower JO. PMID: 12537479.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    88. A ribozyme with michaelase activity: synthesis of the substrate precursors. Bioorg Med Chem. 2003 Jan 17; 11(2):235-49. Eisenführ A, Arora PS, Sengle G, Takaoka LR, Nowick JS, Famulok M. PMID: 12470718.
      View in: PubMed   Mentions: 8     Fields:    
    89. Methylglyoxal synthetase, enol-pyruvaldehyde, glutathione and the glyoxalase system. J Am Chem Soc. 2002 Nov 06; 124(44):13047-52. Rose IA, Nowick JS. PMID: 12405831.
      View in: PubMed   Mentions: 4     Fields:    
    90. An unnatural amino acid that induces beta-sheet folding and interaction in peptides. J Am Chem Soc. 2002 May 08; 124(18):4972-3. Nowick JS, Lam KS, Khasanova TV, Kemnitzer WE, Maitra S, Mee HT, Liu R. PMID: 11982357.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    91. A triply templated artificial beta-sheet. J Am Chem Soc. 2001 Jun 06; 123(22):5176-80. Nowick JS, Cary JM, Tsai JH. PMID: 11457378.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    92. Novel RNA catalysts for the Michael reaction. Chem Biol. 2001 May; 8(5):459-73. Sengle G, Eisenführ A, Arora PS, Nowick JS, Famulok M. PMID: 11358693.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    93. Fmoc: a more soluble analogue of the 9-fluorenylmethoxycarbonyl protecting group. J Org Chem. 2000 Jun 16; 65(12):3858-60. Stigers KD, Koutroulis MR, Chung DM, Nowick JS. PMID: 10864776.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    94. Synthesis, incorporation efficiency, and stability of disulfide bridged functional groups at RNA 5'-ends. Bioorg Med Chem. 2000 Jun; 8(6):1317-29. Sengle G, Jenne A, Arora PS, Seelig B, Nowick JS, Jäschke A, Famulok M. PMID: 10896110.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    95. Designed molecules that fold to mimic protein secondary structures. Curr Opin Chem Biol. 1999 Dec; 3(6):714-23. Stigers KD, Soth MJ, Nowick JS. PMID: 10600726.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    96. A Peptide/Oligourea/Azapeptide Hybrid That Adopts a Hairpin Turn. J Org Chem. 1999 Jan 08; 64(1):276-281. Soth MJ, Nowick JS. PMID: 11674113.
      View in: PubMed   Mentions: 2     Fields:    
    97. Two new beta-strand mimics. Bioorg Med Chem. 1999 Jan; 7(1):29-38. Tsai JH, Waldman AS, Nowick JS. PMID: 10199654.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    98. Design and synthesis of a transition state analogue for the Diels-Alder reaction. Bioorg Med Chem. 1998 Sep; 6(9):1421-8. Arora PS, Van QN, Famulok M, Shaka AJ, Nowick JS. PMID: 9801813.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    99. An Artificial Antiparallel beta-Sheet Containing a New Peptidomimetic Template. J Org Chem. 1997 Nov 14; 62(23):7906-7907. Smith EM, Holmes DL, Shaka AJ, Nowick JS. PMID: 11671886.
      View in: PubMed   Mentions: 2     Fields:    
    100. Unnatural oligomers and unnatural oligomer libraries. Curr Opin Chem Biol. 1997 Jun; 1(1):120-9. Soth MJ, Nowick JS. PMID: 9667839.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    101. Synthesis of Peptide Isocyanates and Isothiocyanates. J Org Chem. 1996 May 31; 61(11):3929-3934. Nowick JS, Holmes DL, Noronha G, Smith EM, Nguyen TM, Huang SL. PMID: 11667260.
      View in: PubMed   Mentions: 9     Fields:    
    102. Molecular Recognition between Uncharged Molecules in Aqueous Micelles. J Am Chem Soc. 1994 Apr 01; 116(8):3285-9. Nowick JS, Cao T, Noronha G. PMID: 25084234.
      View in: PubMed   Mentions: 5     Fields:    
    103. Self-replicating systems. Acta Chem Scand. 1992 Apr; 46(4):315-24. Famulok M, Nowick JS, Rebek J. PMID: 1381212.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
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