James S Nowick

Title(s)Professor, Pharmaceutical Sciences
SchoolSchool of Pharmacy and Pharmaceutical Sciences
Address101 Theory, Suite 100
Irvine CA 92697-3958
Phone(949) 824-6091
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    Collapse Research 
    Collapse Research Activities and Funding
    Structural and Biological Characterization of Diverse Oligomers Derived from Abeta
    NIH RF1AG072587May 1, 2021 - Apr 30, 2024
    Role: Principal Investigator
    Amyloidogenic Antibiotics
    NIH R21AI156565Nov 20, 2020 - Oct 31, 2022
    Role: Principal Investigator
    Antibodies Against Conformationally Defined Amyloid Oligomers in Alzheimer?s Disease
    NIH RF1AG062296Sep 30, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Development of Teixobactin Analogues
    NIH R56AI137258Aug 21, 2018 - Jul 31, 2021
    Role: Principal Investigator
    Synthesis and Studies of a New Family of Antibiotics
    NIH R21AI121548Mar 1, 2016 - Feb 28, 2019
    Role: Principal Investigator
    Mimicry of Amyloid Oligomers
    NIH R01GM097562Feb 1, 2012 - Jan 31, 2021
    Role: Principal Investigator
    Chemical Models of Protein beta-Sheet Interactions
    NIH R01GM049076Apr 1, 1994 - Nov 30, 2010
    Role: Principal Investigator
    NEW STRATEGIES FOR FORMATION OF PEPTIDE BETA-SHEETS
    NIH R29GM049076Apr 1, 1994 - Mar 31, 1999
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Synthesis and Stereochemical Determination of the Peptide Antibiotic Novo29. J Org Chem. 2023 02 17; 88(4):2214-2220. Krumberger M, Li X, Kreutzer AG, Peoples AJ, Nitti AG, Cunningham AM, Jones CR, Achorn C, Ling LL, Hughes DE, Nowick JS. PMID: 36655882; PMCID: PMC9942206.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    2. Isobactins: O-acyl isopeptide prodrugs of teixobactin and teixobactin derivatives. Chem Sci. 2022 Nov 16; 13(44):13110-13116. Jones CR, Guaglianone G, Lai GH, Nowick JS. PMID: 36425497; PMCID: PMC9667932.
      View in: PubMed   Mentions:
    3. Teixobactin kills bacteria by a two-pronged attack on the cell envelope. Nature. 2022 08; 608(7922):390-396. Shukla R, Lavore F, Maity S, Derks MGN, Jones CR, Vermeulen BJA, Melcrová A, Morris MA, Becker LM, Wang X, Kumar R, Medeiros-Silva J, van Beekveld RAM, Bonvin AMJJ, Lorent JH, Lelli M, Nowick JS, MacGillavry HD, Peoples AJ, Spoering AL, Ling LL, Hughes DE, Roos WH, Breukink E, Lewis K, Weingarth M. PMID: 35922513; PMCID: PMC9365693.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    4. Elucidating the Oligomerization and Cellular Interactions of a Trimer Derived from Aβ through Fluorescence and Mass Spectrometric Studies. ACS Chem Neurosci. 2022 Aug 17; 13(16):2473-2482. Guaglianone G, Torrado B, Lin YF, Watkins MC, Wysocki VH, Gratton E, Nowick JS. PMID: 35892278; PMCID: PMC9389591.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Current Peptide Vaccine and Immunotherapy Approaches Against Alzheimer's Disease. Pept Sci (Hoboken). 2023 Jan; 115(1). Parrocha CMT, Nowick JS. PMID: 36778914; PMCID: PMC9916509.
      View in: PubMed   Mentions: 3  
    6. Enantiomeric β-sheet peptides from Aβ form homochiral pleated β-sheets rather than heterochiral rippled β-sheets. Chem Sci. 2022 Jul 06; 13(26):7739-7746. Li X, Rios SE, Nowick JS. PMID: 35865901; PMCID: PMC9258340.
      View in: PubMed   Mentions: 2  
    7. Visualizing the mode of action and supramolecular assembly of teixobactin analogues in Bacillus subtilis. Chem Sci. 2022 Jul 06; 13(26):7747-7754. Morris MA, Vallmitjana A, Grein F, Schneider T, Arts M, Jones CR, Nguyen BT, Hashemian MH, Malek M, Gratton E, Nowick JS. PMID: 35865902; PMCID: PMC9258396.
      View in: PubMed   Mentions: 1  
    8. Editorial. Eur J Med Chem. 2022 06 05; 236:114340. Moitessier N, Nowick J. PMID: 35405398; PMCID: PMC8970607.
      View in: PubMed   Mentions:    Fields:    
    9. Effects of Familial Alzheimer's Disease Mutations on the Assembly of a β-Hairpin Peptide Derived from Aβ16-36. Biochemistry. 2022 03 15; 61(6):446-454. McKnelly KJ, Kreutzer AG, Howitz WJ, Haduong K, Yoo S, Hart C, Nowick JS. PMID: 35213141; PMCID: PMC9042424.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. Macrocyclic Peptides Derived from Familial Alzheimer's Disease Mutants Show Charge-Dependent Oligomeric Assembly and Toxicity. ACS Chem Neurosci. 2022 03 16; 13(6):714-720. Howitz WJ, Guaglianone G, McKnelly KJ, Haduong K, Ashby SN, Laayouni M, Nowick JS. PMID: 35191689; PMCID: PMC9042422.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. A Disulfide-Stabilized Aβ that Forms Dimers but Does Not Form Fibrils. Biochemistry. 2022 02 15; 61(4):252-264. Zhang S, Yoo S, Snyder DT, Katz BB, Henrickson A, Demeler B, Wysocki VH, Kreutzer AG, Nowick JS. PMID: 35080857; PMCID: PMC9083094.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    12. Synthesis and application of fluorescent teixobactin analogs. Methods Enzymol. 2022; 665:233-258. Morris MA, Jones CR, Nowick JS. PMID: 35379436; PMCID: PMC9109785.
      View in: PubMed   Mentions:    Fields:    
    13. Editorial overview: Amyloid-inspired synthetic biomolecules. Curr Opin Chem Biol. 2021 10; 64:A3-A6. Petersson EJ, Nowick JS. PMID: 34656424.
      View in: PubMed   Mentions:    Fields:    
    14. Visualizing Teixobactin Supramolecular Assemblies and Cell Wall Damage in B. Subtilis Using CryoEM. ACS Omega. 2021 Oct 19; 6(41):27412-27417. Hurst PJ, Morris MA, Graham AA, Nowick JS, Patterson JP. PMID: 34693162; PMCID: PMC8529686.
      View in: PubMed   Mentions: 2  
    15. An Improved Turn Structure for Inducing β-Hairpin Formation in Peptides. Angew Chem Int Ed Engl. 2021 10 11; 60(42):22776-22782. Li X, Sabol AL, Wierzbicki M, Salveson PJ, Nowick JS. PMID: 34258835; PMCID: PMC8490300.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    16. Exploring amyloid oligomers with peptide model systems. Curr Opin Chem Biol. 2021 10; 64:106-115. Samdin TD, Kreutzer AG, Nowick JS. PMID: 34229162; PMCID: PMC9042423.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    17. Correction to "Expression of N-Terminal Cysteine Aβ42 and Conjugation to Generate Fluorescent and Biotinylated Aβ42". Biochemistry. 2021 Jul 20; 60(28):2272-2273. Zhang S, Guaglianone G, Morris MA, Yoo S, Howitz WJ, Xing L, Zheng JG, Jusuf H, Huizar G, Lin J, Kreutzer AG, Nowick JS. PMID: 34213906.
      View in: PubMed   Mentions:    Fields:    
    18. Synthesis and study of macrocyclic β-hairpin peptides for investigating amyloid oligomers. Methods Enzymol. 2021; 656:123-168. Guaglianone G, Kreutzer AG, Nowick JS. PMID: 34325785; PMCID: PMC9053554.
      View in: PubMed   Mentions:    Fields:    
    19. A cyclic peptide inhibitor of the SARS-CoV-2 main protease. Eur J Med Chem. 2021 Oct 05; 221:113530. Kreutzer AG, Krumberger M, Diessner EM, Parrocha CMT, Morris MA, Guaglianone G, Butts CT, Nowick JS. PMID: 34023738; PMCID: PMC8096527.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    20. Expression of N-Terminal Cysteine Aβ42 and Conjugation to Generate Fluorescent and Biotinylated Aβ42. Biochemistry. 2021 04 20; 60(15):1191-1200. Zhang S, Guaglianone G, Morris MA, Yoo S, Howitz WJ, Xing L, Zheng JG, Jusuf H, Huizar G, Lin J, Kreutzer AG, Nowick JS. PMID: 33793198; PMCID: PMC9059633.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    21. Structure-based drug design of an inhibitor of the SARS-CoV-2 (COVID-19) main protease using free software: A tutorial for students and scientists. Eur J Med Chem. 2021 Jun 05; 218:113390. Zhang S, Krumberger M, Morris MA, Parrocha CMT, Kreutzer AG, Nowick JS. PMID: 33812315; PMCID: PMC7980496.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    22. Phenylalanine Mutation to Cyclohexylalanine Facilitates Triangular Trimer Formation by β-Hairpins Derived from Aβ. J Am Chem Soc. 2020 12 09; 142(49):20708-20716. Haerianardakani S, Kreutzer AG, Salveson PJ, Samdin TD, Guaglianone GE, Nowick JS. PMID: 33237748; PMCID: PMC7821965.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    23. Correction to "Interpenetrating Cubes in the X-ray Crystallographic Structure of a Peptide Derived from Medin19-36". J Am Chem Soc. 2020 Nov 04; 142(44):18998. Howitz WJ, Wierzbicki M, Cabanela RW, Saliba C, Motavalli A, Tran N, Nowick JS. PMID: 33086010.
      View in: PubMed   Mentions:    Fields:    
    24. Interpenetrating Cubes in the X-ray Crystallographic Structure of a Peptide Derived from Medin19-36. J Am Chem Soc. 2020 09 16; 142(37):15870-15875. Howitz WJ, Wierzbicki M, Cabanela RW, Saliba C, Motavalli A, Tran N, Nowick JS. PMID: 32816461; PMCID: PMC7819122.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    25. Structure-Based Drug Design of an Inhibitor of the SARS-CoV-2 (COVID-19) Main Protease Using Free Software: A Tutorial for Students and Scientists. ChemRxiv. 2020 Aug 12. Zhang S, Krumberger M, Morris MA, Parrocha CMT, Griffin JH, Kreutzer AG, Nowick JS. PMID: 32817929; PMCID: PMC7430054.
      View in: PubMed   Mentions:
    26. X-ray Crystallography Reveals Parallel and Antiparallel β-Sheet Dimers of a β-Hairpin Derived from Aβ16-36 that Assemble to Form Different Tetramers. ACS Chem Neurosci. 2020 08 05; 11(15):2340-2347. Kreutzer AG, Samdin TD, Guaglianone G, Spencer RK, Nowick JS. PMID: 32584538; PMCID: PMC7811405.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    27. Effects of N-Terminal Residues on the Assembly of Constrained β-Hairpin Peptides Derived from Aβ. J Am Chem Soc. 2020 07 01; 142(26):11593-11601. Samdin TD, Wierzbicki M, Kreutzer AG, Howitz WJ, Valenzuela M, Smith A, Sahrai V, Truex NL, Klun M, Nowick JS. PMID: 32501687; PMCID: PMC7927569.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    28. A Fluorescent Teixobactin Analogue. ACS Chem Biol. 2020 05 15; 15(5):1222-1231. Morris MA, Malek M, Hashemian MH, Nguyen BT, Manuse S, Lewis K, Nowick JS. PMID: 32045203; PMCID: PMC7814985.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    29. Anaphylaxis Induced by Peptide Coupling Agents: Lessons Learned from Repeated Exposure to HATU, HBTU, and HCTU. J Org Chem. 2020 02 07; 85(3):1764-1768. McKnelly KJ, Sokol W, Nowick JS. PMID: 31849224.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    30. Structural Interaction of Apolipoprotein A-I Mimetic Peptide with Amyloid-β Generates Toxic Hetero-oligomers. J Mol Biol. 2020 02 14; 432(4):1020-1034. Sahoo BR, Bekier ME, Liu Z, Kocman V, Stoddard AK, Anantharamaiah GM, Nowick J, Fierke CA, Wang Y, Ramamoorthy A. PMID: 31866295; PMCID: PMC7054163.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    31. Design, Synthesis, and Study of Lactam and Ring-Expanded Analogues of Teixobactin. J Org Chem. 2020 02 07; 85(3):1331-1339. Yang H, Pishenko AV, Li X, Nowick JS. PMID: 31746604; PMCID: PMC7814697.
      View in: PubMed   Mentions: 4     Fields:    
    32. Structure-Based Peptide Inhibitor Design of Amyloid-β Aggregation. Front Mol Neurosci. 2019; 12:54. Lu J, Cao Q, Wang C, Zheng J, Luo F, Xie J, Li Y, Ma X, He L, Eisenberg D, Nowick J, Jiang L, Li D. PMID: 30886570; PMCID: PMC6409328.
      View in: PubMed   Mentions: 21  
    33. Structural Polymorphs Suggest Competing Pathways for the Formation of Amyloid Fibrils That Diverge from a Common Intermediate Species. Biochemistry. 2018 11 20; 57(46):6470-6478. Buchanan LE, Maj M, Dunkelberger EB, Cheng PN, Nowick JS, Zanni MT. PMID: 30375231; PMCID: PMC6368979.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    34. Correction to "Repurposing Triphenylmethane Dyes To Bind to Trimers Derived from Aβ". J Am Chem Soc. 2018 Nov 14; 140(45):15546. Salveson PJ, Haerianardakani S, Thuy-Boun A, Yoo S, Kreutzer AG, Demeler B, Nowick JS. PMID: 30394740.
      View in: PubMed   Mentions:    Fields:    
    35. X-ray Crystallographic Structure of a Teixobactin Derivative Reveals Amyloid-like Assembly. J Am Chem Soc. 2018 10 31; 140(43):14028-14032. Yang H, Wierzbicki M, Du Bois DR, Nowick JS. PMID: 30296063; PMCID: PMC6356018.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    36. Repurposing Triphenylmethane Dyes to Bind to Trimers Derived from Aβ. J Am Chem Soc. 2018 09 19; 140(37):11745-11754. Salveson PJ, Haerianardakani S, Thuy-Boun A, Yoo S, Kreutzer AG, Demeler B, Nowick JS. PMID: 30125493; PMCID: PMC6339561.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    37. An Efficient Method for the Expression and Purification of Aβ(M1-42). Biochemistry. 2018 07 03; 57(26):3861-3866. Yoo S, Zhang S, Kreutzer AG, Nowick JS. PMID: 29757632; PMCID: PMC6320699.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    38. Controlling the Oligomerization State of Aβ-Derived Peptides with Light. J Am Chem Soc. 2018 05 02; 140(17):5842-5852. Salveson PJ, Haerianardakani S, Thuy-Boun A, Kreutzer AG, Nowick JS. PMID: 29627987; PMCID: PMC6361387.
      View in: PubMed   Mentions: 11     Fields:    
    39. Elucidating the Structures of Amyloid Oligomers with Macrocyclic β-Hairpin Peptides: Insights into Alzheimer's Disease and Other Amyloid Diseases. Acc Chem Res. 2018 03 20; 51(3):706-718. Kreutzer AG, Nowick JS. PMID: 29508987; PMCID: PMC5911177.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    40. A Hexamer of a Peptide Derived from Aβ16-36. Biochemistry. 2017 11 14; 56(45):6061-6071. Kreutzer AG, Spencer RK, McKnelly KJ, Yoo S, Hamza IL, Salveson PJ, Nowick JS. PMID: 29028351; PMCID: PMC5689071.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    41. Alanine scan reveals modifiable residues in teixobactin. Chem Commun (Camb). 2017 Oct 12; 53(82):11357-11359. Chen KH, Le SP, Han X, Frias JM, Nowick JS. PMID: 28967925; PMCID: PMC6361391.
      View in: PubMed   Mentions: 13     Fields:    
    42. Effects of charge and hydrophobicity on the oligomerization of peptides derived from IAPP. Bioorg Med Chem. 2018 03 15; 26(6):1151-1156. Wang Y, Truex NL, Vo NDP, Nowick JS. PMID: 29074350.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    43. Transmembrane Proteins: Amyloids Hidden in Plain Sight? Biochemistry. 2017 09 12; 56(36):4735-4736. Truex NL, Nowick JS. PMID: 28853555; PMCID: PMC7556710.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    44. A Tetramer Derived from Islet Amyloid Polypeptide. J Org Chem. 2017 08 04; 82(15):7905-7912. Wang Y, Kreutzer AG, Truex NL, Nowick JS. PMID: 28661686; PMCID: PMC7532939.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    45. X-ray Crystallographic Structure of a Compact Dodecamer from a Peptide Derived from Aβ16-36. Org Lett. 2017 07 07; 19(13):3462-3465. Salveson PJ, Spencer RK, Kreutzer AG, Nowick JS. PMID: 28683555; PMCID: PMC5776032.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    46. X-ray Crystallographic Structure of a Giant Double-Walled Peptide Nanotube Formed by a Macrocyclic β-Sheet Containing Aβ16-22. J Am Chem Soc. 2017 06 21; 139(24):8102-8105. Chen KH, Corro KA, Le SP, Nowick JS. PMID: 28598147.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    47. X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore. Chem Commun (Camb). 2017 Feb 28; 53(18):2772-2775. Yang H, Du Bois DR, Ziller JW, Nowick JS. PMID: 28217800; PMCID: PMC5381722.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    48. Stabilization, Assembly, and Toxicity of Trimers Derived from Aβ. J Am Chem Soc. 2017 01 18; 139(2):966-975. Kreutzer AG, Yoo S, Spencer RK, Nowick JS. PMID: 28001392; PMCID: PMC5256483.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    49. Assembly of Peptides Derived from β-Sheet Regions of β-Amyloid. J Am Chem Soc. 2016 10 26; 138(42):13882-13890. Truex NL, Wang Y, Nowick JS. PMID: 27642651; PMCID: PMC5089065.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    50. Coassembly of Peptides Derived from β-Sheet Regions of β-Amyloid. J Am Chem Soc. 2016 10 26; 138(42):13891-13900. Truex NL, Nowick JS. PMID: 27642763; PMCID: PMC5089069.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    51. Square channels formed by a peptide derived from transthyretin. Chem Sci. 2016 Dec 01; 7(12):6946-6951. Yoo S, Kreutzer AG, Truex NL, Nowick JS. PMID: 28451128; PMCID: PMC5355858.
      View in: PubMed   Mentions: 5  
    52. Elucidation of the Teixobactin Pharmacophore. ACS Chem Biol. 2016 07 15; 11(7):1823-6. Yang H, Chen KH, Nowick JS. PMID: 27232661; PMCID: PMC5283680.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    53. X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an Aβ17-36 β-Hairpin. J Am Chem Soc. 2016 Apr 06; 138(13):4634-42. Kreutzer AG, Hamza IL, Spencer RK, Nowick JS. PMID: 26967810; PMCID: PMC4831588.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    54. X-ray Crystallographic Structure of Oligomers Formed by a Toxic β-Hairpin Derived from α-Synuclein: Trimers and Higher-Order Oligomers. J Am Chem Soc. 2016 Apr 06; 138(13):4458-67. Salveson PJ, Spencer RK, Nowick JS. PMID: 26926877; PMCID: PMC4825732.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    55. Diversification of β-Augmentation Interactions between CDI Toxin/Immunity Proteins. J Mol Biol. 2015 Nov 20; 427(23):3766-84. Morse RP, Willett JL, Johnson PM, Zheng J, Credali A, Iniguez A, Nowick JS, Hayes CS, Goulding CW. PMID: 26449640; PMCID: PMC4658667.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    56. A Newcomer's Guide to Peptide Crystallography. Isr J Chem. 2015 Jun 01; 55(6-7):698-710. Spencer RK, Nowick JS. PMID: 26213415; PMCID: PMC4508863.
      View in: PubMed   Mentions: 13  
    57. X-ray Crystallographic Structures of Oligomers of Peptides Derived from β2-Microglobulin. J Am Chem Soc. 2015 May 20; 137(19):6304-11. Spencer RK, Kreutzer AG, Salveson PJ, Li H, Nowick JS. PMID: 25915729; PMCID: PMC4523215.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    58. A fibril-like assembly of oligomers of a peptide derived from β-amyloid. J Am Chem Soc. 2014 Sep 10; 136(36):12682-90. Pham JD, Spencer RK, Chen KH, Nowick JS. PMID: 25068693; PMCID: PMC4183627.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    59. X-ray crystallographic structures of trimers and higher-order oligomeric assemblies of a peptide derived from Aβ(17-36). J Am Chem Soc. 2014 Apr 16; 136(15):5595-8. Spencer RK, Li H, Nowick JS. PMID: 24669800; PMCID: PMC4004244.
      View in: PubMed   Mentions: 47     Fields:    Translation:Cells
    60. Polymorphism of oligomers of a peptide from β-amyloid. J Am Chem Soc. 2014 Apr 09; 136(14):5432-42. Pham JD, Demeler B, Nowick JS. PMID: 24669785; PMCID: PMC4004211.
      View in: PubMed   Mentions: 14     Fields:    
    61. Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient β-sheet. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19285-90. Buchanan LE, Dunkelberger EB, Tran HQ, Cheng PN, Chiu CC, Cao P, Raleigh DP, de Pablo JJ, Nowick JS, Zanni MT. PMID: 24218609; PMCID: PMC3845187.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansCells
    62. Structures of oligomers of a peptide from β-amyloid. J Am Chem Soc. 2013 Aug 21; 135(33):12460-7. Pham JD, Chim N, Goulding CW, Nowick JS. PMID: 23927812; PMCID: PMC3787202.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    63. A hydrophobic surface is essential to inhibit the aggregation of a tau-protein-derived hexapeptide. J Am Chem Soc. 2013 May 08; 135(18):6846-52. Zheng J, Baghkhanian AM, Nowick JS. PMID: 23627648.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    64. The supramolecular chemistry of β-sheets. J Am Chem Soc. 2013 Apr 17; 135(15):5477-92. Cheng PN, Pham JD, Nowick JS. PMID: 23548073; PMCID: PMC3642101.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    65. Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Proc Natl Acad Sci U S A. 2012 Dec 18; 109(51):20913-8. Liu C, Zhao M, Jiang L, Cheng PN, Park J, Sawaya MR, Pensalfini A, Gou D, Berk AJ, Glabe CG, Nowick J, Eisenberg D. PMID: 23213214; PMCID: PMC3529048.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansCells
    66. Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity. Nat Chem. 2012 Nov; 4(11):927-33. Cheng PN, Liu C, Zhao M, Eisenberg D, Nowick JS. PMID: 23089868; PMCID: PMC3481199.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    67. Heterodivalent linked macrocyclic β-sheets with enhanced activity against Aβ aggregation: two sites are better than one. J Am Chem Soc. 2012 Aug 29; 134(34):14179-84. Cheng PN, Spencer R, Woods RJ, Glabe CG, Nowick JS. PMID: 22827298; PMCID: PMC3430741.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    68. Giant macrolactams based on β-sheet peptides. J Org Chem. 2011 May 06; 76(9):3166-73. Cheng PN, Nowick JS. PMID: 21452877; PMCID: PMC3088102.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    69. Characteristics of amyloid-related oligomers revealed by crystal structures of macrocyclic β-sheet mimics. J Am Chem Soc. 2011 May 04; 133(17):6736-44. Liu C, Sawaya MR, Cheng PN, Zheng J, Nowick JS, Eisenberg D. PMID: 21473620; PMCID: PMC3124511.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    70. Macrocyclic β-sheet peptides that inhibit the aggregation of a tau-protein-derived hexapeptide. J Am Chem Soc. 2011 Mar 09; 133(9):3144-57. Zheng J, Liu C, Sawaya MR, Vadla B, Khan S, Woods RJ, Eisenberg D, Goux WJ, Nowick JS. PMID: 21319744; PMCID: PMC3048834.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    71. X-ray crystallographic structure of an artificial beta-sheet dimer. J Am Chem Soc. 2010 Aug 25; 132(33):11622-8. Khakshoor O, Lin AJ, Korman TP, Sawaya MR, Tsai SC, Eisenberg D, Nowick JS. PMID: 20669960; PMCID: PMC2929266.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    72. Nanometer-scale water-soluble macrocycles from nanometer-sized amino acids. J Org Chem. 2010 Mar 19; 75(6):1822-30. Gothard CM, Nowick JS. PMID: 20020731; PMCID: PMC2837776.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    73. Selective heteronuclear Hartmann-Hahn: a multiple-pulse sequence for selective magnetization transfer in the structural elucidation of "isotagged" oligosaccharides. J Magn Reson. 2010 Mar; 203(1):73-80. Meng X, Nguyen WH, Nowick JS, Shaka AJ. PMID: 20044287.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    74. Use of disulfide "staples" to stabilize beta-sheet quaternary structure. Org Lett. 2009 Jul 16; 11(14):3000-3. Khakshoor O, Nowick JS. PMID: 19534505; PMCID: PMC2726807.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    75. A new artificial beta-sheet that dimerizes through parallel beta-sheet interactions. Org Lett. 2009 Feb 19; 11(4):1003-6. Levin S, Nowick JS. PMID: 19173616; PMCID: PMC2652689.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    76. Functionalized analogues of an unnatural amino acid that mimics a tripeptide beta-strand. Org Lett. 2008 Nov 20; 10(22):5293-6. Khasanova TV, Khakshoor O, Nowick JS. PMID: 18937484; PMCID: PMC2659333.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    77. Exploring beta-sheet structure and interactions with chemical model systems. Acc Chem Res. 2008 Oct; 41(10):1319-30. Nowick JS. PMID: 18798654; PMCID: PMC2728010.
      View in: PubMed   Mentions: 43     Fields:    Translation:Cells
    78. Artificial beta-sheets: chemical models of beta-sheets. Curr Opin Chem Biol. 2008 Dec; 12(6):722-9. Khakshoor O, Nowick JS. PMID: 18775794; PMCID: PMC2646360.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    79. An artificial beta-sheet that dimerizes through parallel beta-sheet interactions. J Am Chem Soc. 2007 Oct 31; 129(43):13043-8. Levin S, Nowick JS. PMID: 17918935; PMCID: PMC2593858.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    80. Nanometer-sized amino acids for the synthesis of nanometer-scale water-soluble molecular rods of precise length. J Am Chem Soc. 2007 Jun 13; 129(23):7272-3. Gothard CM, Rao NA, Nowick JS. PMID: 17503829; PMCID: PMC2552997.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    81. Macrocyclic beta-sheet peptides that mimic protein quaternary structure through intermolecular beta-sheet interactions. J Am Chem Soc. 2007 May 02; 129(17):5558-69. Khakshoor O, Demeler B, Nowick JS. PMID: 17419629; PMCID: PMC2596933.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    82. Cyclic modular beta-sheets. J Am Chem Soc. 2007 Mar 07; 129(9):2548-58. Woods RJ, Brower JO, Castellanos E, Hashemzadeh M, Khakshoor O, Russu WA, Nowick JS. PMID: 17295482; PMCID: PMC2597679.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    83. A new class of macrocyclic receptors from iota-peptides. J Am Chem Soc. 2007 Feb 14; 129(6):1486-7. Kang SW, Gothard CM, Maitra S, Nowick JS. PMID: 17243690.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    84. What I have learned by using chemical model systems to study biomolecular structure and interactions. Org Biomol Chem. 2006 Nov 07; 4(21):3869-85. Nowick JS. PMID: 17047863.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    85. The absence of favorable aromatic interactions between beta-sheet peptides. J Am Chem Soc. 2005 Jul 20; 127(28):9998-9. Chung DM, Dou Y, Baldi P, Nowick JS. PMID: 16011353.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    86. ICBS: a database of interactions between protein chains mediated by beta-sheet formation. Bioinformatics. 2004 Nov 01; 20(16):2767-77. Dou Y, Baisnée PF, Pollastri G, Pécout Y, Nowick J, Baldi P. PMID: 15166020.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    87. Enantioselective molecular recognition between beta-sheets. J Am Chem Soc. 2004 Mar 17; 126(10):3062-3. Chung DM, Nowick JS. PMID: 15012131.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    88. DSA: a new internal standard for NMR studies in aqueous solution. Org Lett. 2003 Sep 18; 5(19):3511-3. Nowick JS, Khakshoor O, Hashemzadeh M, Brower JO. PMID: 12967312.
      View in: PubMed   Mentions: 20     Fields:    
    89. Sequence-selective molecular recognition between beta sheets. Angew Chem Int Ed Engl. 2003 Apr 17; 42(15):1765-8. Nowick JS, Chung DM. PMID: 12707901.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    90. Dityrosine cross-linked Abeta peptides: fibrillar beta-structure in Abeta(1-40) is conducive to formation of dityrosine cross-links but a dityrosine cross-link in Abeta(8-14) does not induce beta-structure. Chem Res Toxicol. 2003 Apr; 16(4):531-5. Yoburn JC, Tian W, Brower JO, Nowick JS, Glabe CG, Van Vranken DL. PMID: 12703970.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    91. A new turn structure for the formation of beta-hairpins in peptides. J Am Chem Soc. 2003 Jan 29; 125(4):876-7. Nowick JS, Brower JO. PMID: 12537479.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    92. A ribozyme with michaelase activity: synthesis of the substrate precursors. Bioorg Med Chem. 2003 Jan 17; 11(2):235-49. Eisenführ A, Arora PS, Sengle G, Takaoka LR, Nowick JS, Famulok M. PMID: 12470718.
      View in: PubMed   Mentions: 8     Fields:    
    93. An unnatural amino acid that induces beta-sheet folding and interaction in peptides. J Am Chem Soc. 2002 May 08; 124(18):4972-3. Nowick JS, Lam KS, Khasanova TV, Kemnitzer WE, Maitra S, Mee HT, Liu R. PMID: 11982357.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    94. A triply templated artificial beta-sheet. J Am Chem Soc. 2001 Jun 06; 123(22):5176-80. Nowick JS, Cary JM, Tsai JH. PMID: 11457378.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    95. Novel RNA catalysts for the Michael reaction. Chem Biol. 2001 May; 8(5):459-73. Sengle G, Eisenführ A, Arora PS, Nowick JS, Famulok M. PMID: 11358693.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    96. Fmoc: a more soluble analogue of the 9-fluorenylmethoxycarbonyl protecting group. J Org Chem. 2000 Jun 16; 65(12):3858-60. Stigers KD, Koutroulis MR, Chung DM, Nowick JS. PMID: 10864776.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    97. Synthesis, incorporation efficiency, and stability of disulfide bridged functional groups at RNA 5'-ends. Bioorg Med Chem. 2000 Jun; 8(6):1317-29. Sengle G, Jenne A, Arora PS, Seelig B, Nowick JS, Jäschke A, Famulok M. PMID: 10896110.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    98. Designed molecules that fold to mimic protein secondary structures. Curr Opin Chem Biol. 1999 Dec; 3(6):714-23. Stigers KD, Soth MJ, Nowick JS. PMID: 10600726.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    99. Two new beta-strand mimics. Bioorg Med Chem. 1999 Jan; 7(1):29-38. Tsai JH, Waldman AS, Nowick JS. PMID: 10199654.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    100. Design and synthesis of a transition state analogue for the Diels-Alder reaction. Bioorg Med Chem. 1998 Sep; 6(9):1421-8. Arora PS, Van QN, Famulok M, Shaka AJ, Nowick JS. PMID: 9801813.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    101. Unnatural oligomers and unnatural oligomer libraries. Curr Opin Chem Biol. 1997 Jun; 1(1):120-9. Soth MJ, Nowick JS. PMID: 9667839.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    102. Molecular Recognition between Uncharged Molecules in Aqueous Micelles. J Am Chem Soc. 1994 Apr 01; 116(8):3285-9. Nowick JS, Cao T, Noronha G. PMID: 25084234.
      View in: PubMed   Mentions: 6     Fields:    
    103. Self-replicating systems. Acta Chem Scand (Cph). 1992 Apr; 46(4):315-24. Famulok M, Nowick JS, Rebek J. PMID: 1381212.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
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