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Ivan Soltesz

Title(s)Adjunct Professor, Anatomy and Neurobiology
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    Collapse Research 
    Collapse Research Activities and Funding
    2019 Inhibition in the CNS Gordon Research Conference and Gordon Research Seminar
    NIH/NINDS R13NS111916Apr 1, 2019 - Aug 31, 2019
    Role: Principal Investigator
    Towards a Complete Description of the Circuitry Underlying Sharp Wave-Mediated Memory Replay
    NIH/NINDS U19NS104590Sep 25, 2017 - Jun 30, 2022
    Role: Principal Investigator
    Cannabinoid control of epilepsy
    NIH/NINDS R01NS099457Jul 1, 2017 - Mar 31, 2022
    Role: Principal Investigator
    Towards automated phenotyping in epilepsy
    NIH/NINDS R21NS102908Jul 1, 2017 - Jun 30, 2019
    Role: Principal Investigator
    2017 Inhibition in the CNS Gordon Research Conference and Gordon Research Seminar
    NIH/NINDS R13NS101901Mar 24, 2017 - Mar 23, 2018
    Role: Principal Investigator
    Closed-loop intervention in epilepsy.
    NIH/NINDS R01NS094668Sep 30, 2015 - Aug 31, 2020
    Role: Principal Investigator
    Towards a Complete Description of the Circuitry Underlying Memory replay.
    NIH/NINDS U01NS090583Sep 30, 2014 - Jul 31, 2017
    Role: Principal Investigator
    Optogenetic hub cell control for no seizures, no side-effects in temporal lobe ep
    NIH/NINDS R01NS074702Mar 1, 2011 - Feb 29, 2016
    Role: Principal Investigator
    GABAergic regulation of entorhino-hippocampal excitability in epilepsy.
    NIH/NINDS R01NS074432Feb 1, 2011 - Jan 31, 2016
    Role: Principal Investigator
    Limbic Excitability After Febrile Seizures
    NIH/NINDS R01NS038580Apr 15, 1999 - Mar 31, 2011
    Role: Principal Investigator
    Plasticity of GABAergic inhibition following head injury
    NIH/NINDS R01NS035915Jun 1, 1997 - Feb 28, 2018
    Role: Principal Investigator
    Plasticity Of GABAergic Inhibition Following Head Injury
    NIH/NINDS R37NS035915Jun 1, 1997 - Feb 28, 2013
    Role: Principal Investigator
    PLASTICITY OF GABAERGIC INHIBITION FOLLOWING HEAD INJURY
    NIH/NINDS R29NS035915Jun 1, 1997 - May 31, 2002
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Acharya MM, Baulch JE, Klein PM, Baddour AAD, Apodaca LA, Kramár EA, Alikhani L, Garcia C, Angulo MC, Batra RS, Fallgren CM, Borak TB, Stark CEL, Wood MA, Britten RA, Soltesz I, Limoli CL. New Concerns for Neurocognitive Function during Deep Space Exposures to Chronic, Low Dose-Rate, Neutron Radiation. eNeuro. 2019 Jul/Aug; 6(4). PMID: 31383727.
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    2. Rennó-Costa C, Teixeira DG, Soltesz I. Regulation of gamma-frequency oscillation by feedforward inhibition: A computational modeling study. Hippocampus. 2019 Oct; 29(10):957-970. PMID: 30990954.
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    3. Farrell JS, Nguyen QA, Soltesz I. Resolving the Micro-Macro Disconnect to Address Core Features of Seizure Networks. Neuron. 2019 Mar 20; 101(6):1016-1028. PMID: 30897354.
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    4. Marchionni I, Oberoi M, Soltesz I, Alexander A. Ripple-related firing of identified deep CA1 pyramidal cells in chronic temporal lobe epilepsy in mice. Epilepsia Open. 2019 Jun; 4(2):254-263. PMID: 31168492.
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    5. Farrell JS, Soltesz I. Plants come to mind: phytocannabinoids, endocannabinoids and the control of seizures. Addiction. 2019 Aug; 114(8):1343-1345. PMID: 30589476.
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    6. Zimmermann T, Maroso M, Beer A, Baddenhausen S, Ludewig S, Fan W, Vennin C, Loch S, Berninger B, Hofmann C, Korte M, Soltesz I, Lutz B, Leschik J. Neural stem cell lineage-specific cannabinoid type-1 receptor regulates neurogenesis and plasticity in the adult mouse hippocampus. Cereb Cortex. 2018 12 01; 28(12):4454-4471. PMID: 30307491.
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    7. Huizenga MN, Fureman BE, Soltesz I, Stella N. Proceedings of the Epilepsy Foundation's 2017 Cannabinoids in Epilepsy Therapy Workshop. Epilepsy Behav. 2018 08; 85:237-242. PMID: 29908905.
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    8. Soltesz I, Losonczy A. CA1 pyramidal cell diversity enabling parallel information processing in the hippocampus. Nat Neurosci. 2018 04; 21(4):484-493. PMID: 29593317.
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    9. Parihar VK, Maroso M, Syage A, Allen BD, Angulo MC, Soltesz I, Limoli CL. Persistent nature of alterations in cognition and neuronal circuit excitability after exposure to simulated cosmic radiation in mice. Exp Neurol. 2018 07; 305:44-55. PMID: 29540322.
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    10. Bui AD, Nguyen TM, Limouse C, Kim HK, Szabo GG, Felong S, Maroso M, Soltesz I. Dentate gyrus mossy cells control spontaneous convulsive seizures and spatial memory. Science. 2018 02 16; 359(6377):787-790. PMID: 29449490.
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    11. Neubrandt M, Oláh VJ, Brunner J, Marosi EL, Soltesz I, Szabadics J. Single Bursts of Individual Granule Cells Functionally Rearrange Feedforward Inhibition. J Neurosci. 2018 02 14; 38(7):1711-1724. PMID: 29335356.
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    12. Neumann AR, Raedt R, Steenland HW, Sprengers M, Bzymek K, Navratilova Z, Mesina L, Xie J, Lapointe V, Kloosterman F, Vonck K, Boon PAJM, Soltesz I, McNaughton BL, Luczak A. Involvement of fast-spiking cells in ictal sequences during spontaneous seizures in rats with chronic temporal lobe epilepsy. Brain. 2017 Sep 01; 140(9):2355-2369. PMID: 29050390.
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    13. Milstein AD, Soltesz I. Hippocampal Dentate Mossy Cells Improve Their CV and Trk into the Limelight. Neuron. 2017 Aug 16; 95(4):732-734. PMID: 28817795.
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    14. Szabo GG, Du X, Oijala M, Varga C, Parent JM, Soltesz I. Extended Interneuronal Network of the Dentate Gyrus. Cell Rep. 2017 08 08; 20(6):1262-1268. PMID: 28793251.
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    15. Bezaire MJ, Raikov I, Burk K, Vyas D, Soltesz I. Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit. Elife. 2016 12 23; 5. PMID: 28009257.
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    16. Lee SH, Dudok B, Parihar VK, Jung KM, Zöldi M, Kang YJ, Maroso M, Alexander AL, Nelson GA, Piomelli D, Katona I, Limoli CL, Soltesz I. Neurophysiology of space travel: energetic solar particles cause cell type-specific plasticity of neurotransmission. Brain Struct Funct. 2017 Jul; 222(5):2345-2357. PMID: 27905022.
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    17. Bui AD, Alexander A, Soltesz I. Seizing Control: From Current Treatments to Optogenetic Interventions in Epilepsy. Neuroscientist. 2017 Feb; 23(1):68-81. PMID: 26700888.
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    18. Alexander A, Maroso M, Soltesz I. Organization and control of epileptic circuits in temporal lobe epilepsy. Prog Brain Res. 2016; 226:127-54. PMID: 27323941.
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    19. Maroso M, Szabo GG, Kim HK, Alexander A, Bui AD, Lee SH, Lutz B, Soltesz I. Cannabinoid Control of Learning and Memory through HCN Channels. Neuron. 2016 Mar 02; 89(5):1059-73. PMID: 26898775.
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    20. Alexander A, Soltesz I. Hippogate: a break-in from entorhinal cortex. Nat Neurosci. 2016 Apr; 19(4):530-2. PMID: 26878673.
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    21. Armstrong C, Wang J, Yeun Lee S, Broderick J, Bezaire MJ, Lee SH, Soltesz I. Target-selectivity of parvalbumin-positive interneurons in layer II of medial entorhinal cortex in normal and epileptic animals. Hippocampus. 2016 06; 26(6):779-93. PMID: 26663222.
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    22. Bui A, Kim HK, Maroso M, Soltesz I. Microcircuits in Epilepsy: Heterogeneity and Hub Cells in Network Synchronization. Cold Spring Harb Perspect Med. 2015 Nov 02; 5(11). PMID: 26525454.
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    23. Szabo GG, Soltesz I. Pass-Through Code of Synaptic Integration. Neuron. 2015 Sep 23; 87(6):1124-1126. PMID: 26402596.
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    24. Adamantidis A, Arber S, Bains JS, Bamberg E, Bonci A, Buzsáki G, Cardin JA, Costa RM, Dan Y, Goda Y, Graybiel AM, Häusser M, Hegemann P, Huguenard JR, Insel TR, Janak PH, Johnston D, Josselyn SA, Koch C, Kreitzer AC, Lüscher C, Malenka RC, Miesenböck G, Nagel G, Roska B, Schnitzer MJ, Shenoy KV, Soltesz I, Sternson SM, Tsien RW, Tsien RY, Turrigiano GG, Tye KM, Wilson RI. Optogenetics: 10 years after ChR2 in neurons--views from the community. Nat Neurosci. 2015 Sep; 18(9):1202-12. PMID: 26308981.
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    25. Lee SH, Ledri M, Tóth B, Marchionni I, Henstridge CM, Dudok B, Kenesei K, Barna L, Szabó SI, Renkecz T, Oberoi M, Watanabe M, Limoli CL, Horvai G, Soltesz I, Katona I. Multiple Forms of Endocannabinoid and Endovanilloid Signaling Regulate the Tonic Control of GABA Release. J Neurosci. 2015 Jul 08; 35(27):10039-57. PMID: 26157003.
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    26. Krook-Magnuson E, Gelinas JN, Soltesz I, Buzsáki G. Neuroelectronics and Biooptics: Closed-Loop Technologies in Neurological Disorders. JAMA Neurol. 2015 Jul; 72(7):823-9. PMID: 25961887.
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    27. Nagaraj V, Lee ST, Krook-Magnuson E, Soltesz I, Benquet P, Irazoqui PP, Netoff TI. Future of seizure prediction and intervention: closing the loop. J Clin Neurophysiol. 2015 Jun; 32(3):194-206. PMID: 26035672.
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    28. Soltesz I, Alger BE, Kano M, Lee SH, Lovinger DM, Ohno-Shosaku T, Watanabe M. Weeding out bad waves: towards selective cannabinoid circuit control in epilepsy. Nat Rev Neurosci. 2015 May; 16(5):264-77. PMID: 25891509.
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    29. Raikov I, Soltesz I. A Master Plan for the Epilepsies? Toward a General Theory of Seizure Dynamics. Epilepsy Curr. 2015 May-Jun; 15(3):133-5. PMID: 26316851.
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    30. Krook-Magnuson E, Armstrong C, Bui A, Lew S, Oijala M, Soltesz I. In vivo evaluation of the dentate gate theory in epilepsy. J Physiol. 2015 May 15; 593(10):2379-88. PMID: 25752305.
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    31. Krook-Magnuson E, Soltesz I. Beyond the hammer and the scalpel: selective circuit control for the epilepsies. Nat Neurosci. 2015 Mar; 18(3):331-8. PMID: 25710834.
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    32. Sokolova IV, Schneider CJ, Bezaire M, Soltesz I, Vlkolinsky R, Nelson GA. Proton radiation alters intrinsic and synaptic properties of CA1 pyramidal neurons of the mouse hippocampus. Radiat Res. 2015 Feb; 183(2):208-18. PMID: 25621896.
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    33. Szabo GG, Schneider CJ, Soltesz I. Resolution revolution: epilepsy dynamics at the microscale. Curr Opin Neurobiol. 2015 Apr; 31:239-43. PMID: 25596364.
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    34. Schneider CJ, Soltesz I. Net worth of networks: specificity in anticonvulsant action. Epilepsy Curr. 2015 Jan-Feb; 15(1):45-6. PMID: 25678891.
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    35. Dudok B, Barna L, Ledri M, Szabó SI, Szabadits E, Pintér B, Woodhams SG, Henstridge CM, Balla GY, Nyilas R, Varga C, Lee SH, Matolcsi M, Cervenak J, Kacskovics I, Watanabe M, Sagheddu C, Melis M, Pistis M, Soltesz I, Katona I. Cell-specific STORM super-resolution imaging reveals nanoscale organization of cannabinoid signaling. Nat Neurosci. 2015 Jan; 18(1):75-86. PMID: 25485758.
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    36. Krook-Magnuson E, Szabo GG, Armstrong C, Oijala M, Soltesz I. Cerebellar Directed Optogenetic Intervention Inhibits Spontaneous Hippocampal Seizures in a Mouse Model of Temporal Lobe Epilepsy. eNeuro. 2014 Dec; 1(1). PMID: 25599088.
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    37. Varga C, Oijala M, Lish J, Szabo GG, Bezaire M, Marchionni I, Golshani P, Soltesz I. Functional fission of parvalbumin interneuron classes during fast network events. Elife. 2014 Nov 06; 3. PMID: 25375253.
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    38. Schneider CJ, Cuntz H, Soltesz I. Linking macroscopic with microscopic neuroanatomy using synthetic neuronal populations. PLoS Comput Biol. 2014 Oct; 10(10):e1003921. PMID: 25340814.
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    39. Kim IH, Hevezi P, Varga C, Pathak MM, Hong L, Ta D, Tran CT, Zlotnik A, Soltesz I, Tombola F. Evidence for functional diversity between the voltage-gated proton channel Hv1 and its closest related protein HVRP1. PLoS One. 2014; 9(8):e105926. PMID: 25165868.
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    40. Lee SH, Marchionni I, Bezaire M, Varga C, Danielson N, Lovett-Barron M, Losonczy A, Soltesz I. Parvalbumin-positive basket cells differentiate among hippocampal pyramidal cells. Neuron. 2014 Jun 04; 82(5):1129-44. PMID: 24836505.
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    41. Krook-Magnuson E, Ledri M, Soltesz I, Kokaia M. How might novel technologies such as optogenetics lead to better treatments in epilepsy? Adv Exp Med Biol. 2014; 813:319-36. PMID: 25012388.
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    42. Armstrong C, Krook-Magnuson E, Oijala M, Soltesz I. Closed-loop optogenetic intervention in mice. Nat Protoc. 2013 Aug; 8(8):1475-1493. PMID: 23845961.
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    43. Bezaire MJ, Soltesz I. Quantitative assessment of CA1 local circuits: knowledge base for interneuron-pyramidal cell connectivity. Hippocampus. 2013 Sep; 23(9):751-85. PMID: 23674373.
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    44. Feldt Muldoon S, Soltesz I, Cossart R. Spatially clustered neuronal assemblies comprise the microstructure of synchrony in chronically epileptic networks. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3567-72. PMID: 23401510.
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    45. Krook-Magnuson E, Armstrong C, Oijala M, Soltesz I. On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy. Nat Commun. 2013; 4:1376. PMID: 23340416.
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    46. Schneider CJ, Bezaire M, Soltesz I. Toward a full-scale computational model of the rat dentate gyrus. Front Neural Circuits. 2012; 6:83. PMID: 23162433.
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    47. Varga C, Golshani P, Soltesz I. Frequency-invariant temporal ordering of interneuronal discharges during hippocampal oscillations in awake mice. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):E2726-34. PMID: 23010933.
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    48. Armstrong C, Krook-Magnuson E, Soltesz I. Neurogliaform and Ivy Cells: A Major Family of nNOS Expressing GABAergic Neurons. Front Neural Circuits. 2012; 6:23. PMID: 22623913.
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    49. Armstrong C, Soltesz I. Basket cell dichotomy in microcircuit function. J Physiol. 2012 Feb 15; 590(4):683-94. PMID: 22199164.
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    50. Krook-Magnuson E, Varga C, Lee SH, Soltesz I. New dimensions of interneuronal specialization unmasked by principal cell heterogeneity. Trends Neurosci. 2012 Mar; 35(3):175-84. PMID: 22119146.
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    51. Krook-Magnuson E, Luu L, Lee SH, Varga C, Soltesz I. Ivy and neurogliaform interneurons are a major target of µ-opioid receptor modulation. J Neurosci. 2011 Oct 19; 31(42):14861-70. PMID: 22016519.
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    52. Case M, Soltesz I. Computational modeling of epilepsy. Epilepsia. 2011 Oct; 52 Suppl 8:12-5. PMID: 21967351.
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    53. Soltesz I. The Brain Prize 2011: From Microcircuit Organization to Constellations of Brain Rhythms. Trends Neurosci. 2011 Oct; 34(10):501-3. PMID: 21917323.
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    54. Lee SY, Földy C, Szabadics J, Soltesz I. Cell-type-specific CCK2 receptor signaling underlies the cholecystokinin-mediated selective excitation of hippocampal parvalbumin-positive fast-spiking basket cells. J Neurosci. 2011 Jul 27; 31(30):10993-1002. PMID: 21795548.
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    55. Winterer J, Stempel AV, Dugladze T, Földy C, Maziashvili N, Zivkovic AR, Priller J, Soltesz I, Gloveli T, Schmitz D. Cell-type-specific modulation of feedback inhibition by serotonin in the hippocampus. J Neurosci. 2011 Jun 08; 31(23):8464-75. PMID: 21653851.
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    56. Armstrong C, Szabadics J, Tamás G, Soltesz I. Neurogliaform cells in the molecular layer of the dentate gyrus as feed-forward ?-aminobutyric acidergic modulators of entorhinal-hippocampal interplay. J Comp Neurol. 2011 Jun 01; 519(8):1476-91. PMID: 21452204.
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    57. Lee SY, Soltesz I. Cholecystokinin: a multi-functional molecular switch of neuronal circuits. Dev Neurobiol. 2011 Jan 01; 71(1):83-91. PMID: 21154912.
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    58. Lee SH, Soltesz I. Requirement for CB1 but not GABAB receptors in the cholecystokinin mediated inhibition of GABA release from cholecystokinin expressing basket cells. J Physiol. 2011 Feb 15; 589(Pt 4):891-902. PMID: 21173082.
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    59. Földy C, Lee SH, Morgan RJ, Soltesz I. Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2. Nat Neurosci. 2010 Sep; 13(9):1047-9. PMID: 20676104.
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    60. Szabadics J, Varga C, Brunner J, Chen K, Soltesz I. Granule cells in the CA3 area. J Neurosci. 2010 Jun 16; 30(24):8296-307. PMID: 20554881.
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    61. Lee SH, Földy C, Soltesz I. Distinct endocannabinoid control of GABA release at perisomatic and dendritic synapses in the hippocampus. J Neurosci. 2010 Jun 09; 30(23):7993-8000. PMID: 20534847.
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    62. Varga C, Lee SY, Soltesz I. Target-selective GABAergic control of entorhinal cortex output. Nat Neurosci. 2010 Jul; 13(7):822-4. PMID: 20512133.
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    63. Case M, Soltesz I. Discreet charm of the GABAergic bourgeoisie: superconnected cells conduct developmental symphonies. Neuron. 2009 Dec 24; 64(6):780-2. PMID: 20064385.
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    64. Armstrong C, Morgan RJ, Soltesz I. Pursuing paradoxical proconvulsant prophylaxis for epileptogenesis. Epilepsia. 2009 Jul; 50(7):1657-69. PMID: 19552655.
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    65. Dyhrfjeld-Johnsen J, Morgan RJ, Soltesz I. Double Trouble? Potential for Hyperexcitability Following Both Channelopathic up- and Downregulation of I(h) in Epilepsy. Front Neurosci. 2009 May; 3(1):25-33. PMID: 19753094.
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    66. Echegoyen J, Armstrong C, Morgan RJ, Soltesz I. Single application of a CB1 receptor antagonist rapidly following head injury prevents long-term hyperexcitability in a rat model. Epilepsy Res. 2009 Jul; 85(1):123-7. PMID: 19369036.
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    67. Szabadics J, Soltesz I. Functional specificity of mossy fiber innervation of GABAergic cells in the hippocampus. J Neurosci. 2009 Apr 01; 29(13):4239-51. PMID: 19339618.
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    68. Frey LC, Hellier J, Unkart C, Lepkin A, Howard A, Hasebroock K, Serkova N, Liang L, Patel M, Soltesz I, Staley K. A novel apparatus for lateral fluid percussion injury in the rat. J Neurosci Methods. 2009 Mar 15; 177(2):267-72. PMID: 19022291.
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    69. Dyhrfjeld-Johnsen J, Morgan RJ, Földy C, Soltesz I. Upregulated H-current in hyperexcitable CA1 dendrites after febrile seizures. Front Cell Neurosci. 2008; 2:2. PMID: 18946517.
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    70. Morgan RJ, Soltesz I. Nonrandom connectivity of the epileptic dentate gyrus predicts a major role for neuronal hubs in seizures. Proc Natl Acad Sci U S A. 2008 Apr 22; 105(16):6179-84. PMID: 18375756.
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    71. Szabadics J, Tamás G, Soltesz I. Different transmitter transients underlie presynaptic cell type specificity of GABAA,slow and GABAA,fast. Proc Natl Acad Sci U S A. 2007 Sep 11; 104(37):14831-6. PMID: 17785408.
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    72. Echegoyen J, Neu A, Graber KD, Soltesz I. Homeostatic plasticity studied using in vivo hippocampal activity-blockade: synaptic scaling, intrinsic plasticity and age-dependence. PLoS One. 2007 Aug 08; 2(8):e700. PMID: 17684547.
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    73. Földy C, Lee SY, Szabadics J, Neu A, Soltesz I. Cell type-specific gating of perisomatic inhibition by cholecystokinin. Nat Neurosci. 2007 Sep; 10(9):1128-30. PMID: 17676058.
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    74. Chen K, Neu A, Howard AL, Földy C, Echegoyen J, Hilgenberg L, Smith M, Mackie K, Soltesz I. Prevention of plasticity of endocannabinoid signaling inhibits persistent limbic hyperexcitability caused by developmental seizures. J Neurosci. 2007 Jan 03; 27(1):46-58. PMID: 17202471.
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    75. Morgan RJ, Santhakumar V, Soltesz I. Modeling the dentate gyrus. Prog Brain Res. 2007; 163:639-58. PMID: 17765743.
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    76. Soltesz I, Staley K. High times for memory: cannabis disrupts temporal coordination among hippocampal neurons. Nat Neurosci. 2006 Dec; 9(12):1461-3. PMID: 17128279.
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    77. Dyhrfjeld-Johnsen J, Santhakumar V, Morgan RJ, Huerta R, Tsimring L, Soltesz I. Topological determinants of epileptogenesis in large-scale structural and functional models of the dentate gyrus derived from experimental data. J Neurophysiol. 2007 Feb; 97(2):1566-87. PMID: 17093119.
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    78. Neu A, Földy C, Soltesz I. Postsynaptic origin of CB1-dependent tonic inhibition of GABA release at cholecystokinin-positive basket cell to pyramidal cell synapses in the CA1 region of the rat hippocampus. J Physiol. 2007 Jan 01; 578(Pt 1):233-47. PMID: 17053036.
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    79. Howard AL, Neu A, Morgan RJ, Echegoyen JC, Soltesz I. Opposing modifications in intrinsic currents and synaptic inputs in post-traumatic mossy cells: evidence for single-cell homeostasis in a hyperexcitable network. J Neurophysiol. 2007 Mar; 97(3):2394-409. PMID: 16943315.
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    80. Földy C, Neu A, Jones MV, Soltesz I. Presynaptic, activity-dependent modulation of cannabinoid type 1 receptor-mediated inhibition of GABA release. J Neurosci. 2006 Feb 01; 26(5):1465-9. PMID: 16452670.
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    81. Neu A, Soltesz I. How good vibes turn bad: rise of ictal events from oscillatory network activity. Focus on "transient depression of excitatory synapses on interneurons contributes to epileptogenesis during gamma oscillations in the mouse hippocampal slice". J Neurophysiol. 2005 Aug; 94(2):905-6. PMID: 16061488.
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    82. Echegoyen JC, Soltesz I. Mini-I on epilepsy. Focus on "Changes in mIPSCs and sIPSCs after kainate treatment: evidence for loss of inhibitory input to dentate granule cells and possible compensatory responses". J Neurophysiol. 2005 Aug; 94(2):903-4. PMID: 16061487.
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    83. Sipilä ST, Huttu K, Soltesz I, Voipio J, Kaila K. Depolarizing GABA acts on intrinsically bursting pyramidal neurons to drive giant depolarizing potentials in the immature hippocampus. J Neurosci. 2005 Jun 01; 25(22):5280-9. PMID: 15930375.
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    84. Howard A, Tamas G, Soltesz I. Lighting the chandelier: new vistas for axo-axonic cells. Trends Neurosci. 2005 Jun; 28(6):310-6. PMID: 15927687.
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    85. Lysetskiy M, Földy C, Soltesz I. Long- and short-term plasticity at mossy fiber synapses on mossy cells in the rat dentate gyrus. Hippocampus. 2005; 15(6):691-6. PMID: 15986406.
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    86. Földy C, Dyhrfjeld-Johnsen J, Soltesz I. Structure of cortical microcircuit theory. J Physiol. 2005 Jan 01; 562(Pt 1):47-54. PMID: 15550461.
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    87. Spampanato J, Kearney JA, de Haan G, McEwen DP, Escayg A, Aradi I, MacDonald BT, Levin SI, Soltesz I, Benna P, Montalenti E, Isom LL, Goldin AL, Meisler MH. A novel epilepsy mutation in the sodium channel SCN1A identifies a cytoplasmic domain for beta subunit interaction. J Neurosci. 2004 Nov 03; 24(44):10022-34. PMID: 15525788.
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    88. Dyhrfjeld-Johnsen J, Soltesz I. Dendritic h channelopathy in epileptogenesis. Neuron. 2004 Oct 28; 44(3):402-3. PMID: 15504320.
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    89. Santhakumar V, Aradi I, Soltesz I. Role of mossy fiber sprouting and mossy cell loss in hyperexcitability: a network model of the dentate gyrus incorporating cell types and axonal topography. J Neurophysiol. 2005 Jan; 93(1):437-53. PMID: 15342722.
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    90. Santhakumar V, Soltesz I. Plasticity of interneuronal species diversity and parameter variance in neurological diseases. Trends Neurosci. 2004 Aug; 27(8):504-10. PMID: 15271499.
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    91. Aradi I, Santhakumar V, Soltesz I. Impact of heterogeneous perisomatic IPSC populations on pyramidal cell firing rates. J Neurophysiol. 2004 Jun; 91(6):2849-58. PMID: 15136604.
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    92. Ratzliff Ad, Howard AL, Santhakumar V, Osapay I, Soltesz I. Rapid deletion of mossy cells does not result in a hyperexcitable dentate gyrus: implications for epileptogenesis. J Neurosci. 2004 Mar 03; 24(9):2259-69. PMID: 14999076.
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    93. Földy C, Aradi I, Howard A, Soltesz I. Diversity beyond variance: modulation of firing rates and network coherence by GABAergic subpopulations. Eur J Neurosci. 2004 Jan; 19(1):119-30. PMID: 14750970.
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    94. Spampanato J, Aradi I, Soltesz I, Goldin AL. Increased neuronal firing in computer simulations of sodium channel mutations that cause generalized epilepsy with febrile seizures plus. J Neurophysiol. 2004 May; 91(5):2040-50. PMID: 14702334.
      View in: PubMed
    95. Chen K, Ratzliff A, Hilgenberg L, Gulyás A, Freund TF, Smith M, Dinh TP, Piomelli D, Mackie K, Soltesz I. Long-term plasticity of endocannabinoid signaling induced by developmental febrile seizures. Neuron. 2003 Aug 14; 39(4):599-611. PMID: 12925275.
      View in: PubMed
    96. Santhakumar V, Voipio J, Kaila K, Soltesz I. Post-traumatic hyperexcitability is not caused by impaired buffering of extracellular potassium. J Neurosci. 2003 Jul 02; 23(13):5865-76. PMID: 12843291.
      View in: PubMed
    97. Chen K, Aradi I, Santhakumar V, Soltesz I. H-channels in epilepsy: new targets for seizure control? Trends Pharmacol Sci. 2002 Dec; 23(12):552-7. PMID: 12457772.
      View in: PubMed
    98. Aradi I, Santhakumar V, Chen K, Soltesz I. Postsynaptic effects of GABAergic synaptic diversity: regulation of neuronal excitability by changes in IPSC variance. Neuropharmacology. 2002 Sep; 43(4):511-22. PMID: 12367598.
      View in: PubMed
    99. Ratzliff Ad, Santhakumar V, Howard A, Soltesz I. Mossy cells in epilepsy: rigor mortis or vigor mortis? Trends Neurosci. 2002 Mar; 25(3):140-4. PMID: 11852145.
      View in: PubMed
    100. Aradi I, Soltesz I. Modulation of network behaviour by changes in variance in interneuronal properties. J Physiol. 2002 Jan 01; 538(Pt 1):227-51. PMID: 11773331.
      View in: PubMed
    101. Santhakumar V, Ratzliff AD, Jeng J, Toth Z, Soltesz I. Long-term hyperexcitability in the hippocampus after experimental head trauma. Ann Neurol. 2001 Dec; 50(6):708-17. PMID: 11761468.
      View in: PubMed
    102. Ross ST, Soltesz I. Long-term plasticity in interneurons of the dentate gyrus. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8874-9. PMID: 11438685.
      View in: PubMed
    103. Chen K, Aradi I, Thon N, Eghbal-Ahmadi M, Baram TZ, Soltesz I. Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability. Nat Med. 2001 Mar; 7(3):331-7. PMID: 11231632.
      View in: PubMed
    104. Soltesz I, Nusser Z. Neurobiology. Background inhibition to the fore. Nature. 2001 Jan 04; 409(6816):24-5, 27. PMID: 11343093.
      View in: PubMed
    105. Ratzliff AD, Soltesz I. Differential immunoreactivity for alpha-actinin-2, an N-methyl-D-aspartate-receptor/actin binding protein, in hippocampal interneurons. Neuroscience. 2001; 103(2):337-49. PMID: 11246149.
      View in: PubMed
    106. Ross ST, Soltesz I. Selective depolarization of interneurons in the early posttraumatic dentate gyrus: involvement of the Na(+)/K(+)-ATPase. J Neurophysiol. 2000 May; 83(5):2916-30. PMID: 10805688.
      View in: PubMed
    107. Santhakumar V, Bender R, Frotscher M, Ross ST, Hollrigel GS, Toth Z, Soltesz I. Granule cell hyperexcitability in the early post-traumatic rat dentate gyrus: the 'irritable mossy cell' hypothesis. J Physiol. 2000 Apr 01; 524 Pt 1:117-34. PMID: 10747187.
      View in: PubMed
    108. Dube C, Chen K, Eghbal-Ahmadi M, Brunson K, Soltesz I, Baram TZ. Prolonged febrile seizures in the immature rat model enhance hippocampal excitability long term. Ann Neurol. 2000 Mar; 47(3):336-44. PMID: 10716253.
      View in: PubMed
    109. de Haas Ratzliff A, Soltesz I. Differential expression of cytoskeletal proteins in the dendrites of parvalbumin-positive interneurons versus granule cells in the adult rat dentate gyrus. Hippocampus. 2000; 10(2):162-8. PMID: 10791838.
      View in: PubMed
    110. Dunning DD, Hoover CL, Soltesz I, Smith MA, O'Dowd DK. GABA(A) receptor-mediated miniature postsynaptic currents and alpha-subunit expression in developing cortical neurons. J Neurophysiol. 1999 Dec; 82(6):3286-97. PMID: 10601460.
      View in: PubMed
    111. Chen K, Baram TZ, Soltesz I. Febrile seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits. Nat Med. 1999 Aug; 5(8):888-94. PMID: 10426311.
      View in: PubMed
    112. Hollrigel GS, Ross ST, Soltesz I. Temporal patterns and depolarizing actions of spontaneous GABAA receptor activation in granule cells of the early postnatal dentate gyrus. J Neurophysiol. 1998 Nov; 80(5):2340-51. PMID: 9819247.
      View in: PubMed
    113. Traub RD, Spruston N, Soltesz I, Konnerth A, Whittington MA, Jefferys GR. Gamma-frequency oscillations: a neuronal population phenomenon, regulated by synaptic and intrinsic cellular processes, and inducing synaptic plasticity. Prog Neurobiol. 1998 Aug; 55(6):563-75. PMID: 9670218.
      View in: PubMed
    114. Cotman CW, Hailer NP, Pfister KK, Soltesz I, Schachner M. Cell adhesion molecules in neural plasticity and pathology: similar mechanisms, distinct organizations? Prog Neurobiol. 1998 Aug; 55(6):659-69. PMID: 9670224.
      View in: PubMed
    115. Hollrigel GS, Chen K, Baram TZ, Soltesz I. The pro-convulsant actions of corticotropin-releasing hormone in the hippocampus of infant rats. Neuroscience. 1998 May; 84(1):71-9. PMID: 9522363.
      View in: PubMed
    116. Hollrigel GS, Morris RJ, Soltesz I. Enhanced bursts of IPSCs in dentate granule cells in mice with regionally inhibited long-term potentiation. Proc Biol Sci. 1998 Jan 07; 265(1390):63-9. PMID: 9470216.
      View in: PubMed
    117. Toth Z, Hollrigel GS, Gorcs T, Soltesz I. Instantaneous perturbation of dentate interneuronal networks by a pressure wave-transient delivered to the neocortex. J Neurosci. 1997 Nov 01; 17(21):8106-17. PMID: 9334386.
      View in: PubMed
    118. Hollrigel GS, Soltesz I. Slow kinetics of miniature IPSCs during early postnatal development in granule cells of the dentate gyrus. J Neurosci. 1997 Jul 01; 17(13):5119-28. PMID: 9185549.
      View in: PubMed
    119. Hollrigel GS, Toth K, Soltesz I. Neuroprotection by propofol in acute mechanical injury: role of GABAergic inhibition. J Neurophysiol. 1996 Oct; 76(4):2412-22. PMID: 8899614.
      View in: PubMed
    120. Buckmaster PS, Soltesz I. Neurobiology of hippocampal interneurons: a workshop review. Hippocampus. 1996; 6(3):330-9. PMID: 8841830.
      View in: PubMed
    121. Soltesz I, Smetters DK, Mody I. Tonic inhibition originates from synapses close to the soma. Neuron. 1995 Jun; 14(6):1273-83. PMID: 7605636.
      View in: PubMed
    122. Soltesz I, Mody I. Ca(2+)-dependent plasticity of miniature inhibitory postsynaptic currents after amputation of dendrites in central neurons. J Neurophysiol. 1995 May; 73(5):1763-73. PMID: 7623078.
      View in: PubMed
    123. Soltesz I, Jones RS. The direct perforant path input to CA1: excitatory or inhibitory? Hippocampus. 1995; 5(2):101-3. PMID: 7633509.
      View in: PubMed
    124. Soltesz I. Brief history of cortico-hippocampal time with a special reference to the direct entorhinal input to CA1. Hippocampus. 1995; 5(2):120-4. PMID: 7633513.
      View in: PubMed
    125. Mody I, De Koninck Y, Otis TS, Soltesz I. Bridging the cleft at GABA synapses in the brain. Trends Neurosci. 1994 Dec; 17(12):517-25. PMID: 7532336.
      View in: PubMed
    126. Soltesz I, Zhou Z, Smith GM, Mody I. Rapid turnover rate of the hippocampal synaptic NMDA-R1 receptor subunits. Neurosci Lett. 1994 Nov 07; 181(1-2):5-8. PMID: 7898769.
      View in: PubMed
    127. Turner JP, Leresche N, Guyon A, Soltesz I, Crunelli V. Sensory input and burst firing output of rat and cat thalamocortical cells: the role of NMDA and non-NMDA receptors. J Physiol. 1994 Oct 15; 480 ( Pt 2):281-95. PMID: 7869244.
      View in: PubMed
    128. Soltesz I, Mody I. Patch-clamp recordings reveal powerful GABAergic inhibition in dentate hilar neurons. J Neurosci. 1994 Apr; 14(4):2365-76. PMID: 7908959.
      View in: PubMed
    129. Soltesz I, Bourassa J, Deschênes M. The behavior of mossy cells of the rat dentate gyrus during theta oscillations in vivo. Neuroscience. 1993 Dec; 57(3):555-64. PMID: 8309524.
      View in: PubMed
    130. Soltesz I, Deschênes M. Low- and high-frequency membrane potential oscillations during theta activity in CA1 and CA3 pyramidal neurons of the rat hippocampus under ketamine-xylazine anesthesia. J Neurophysiol. 1993 Jul; 70(1):97-116. PMID: 8395591.
      View in: PubMed
    131. Mody I, Soltesz I. Activity-dependent changes in structure and function of hippocampal neurons. Hippocampus. 1993; 3 Spec No:99-111. PMID: 8287115.
      View in: PubMed
    132. Soltesz I, Crunelli V. A role for low-frequency, rhythmic synaptic potentials in the synchronization of cat thalamocortical cells. J Physiol. 1992 Nov; 457:257-76. PMID: 1297834.
      View in: PubMed
    133. Aszodi A, Crunelli V, Soltesz I. Detecting changes in neuronal activities induced by N-methyl-D-aspartate receptor blockade using non-linear dynamics techniques. Neuroscience. 1992; 46(4):785-91. PMID: 1347409.
      View in: PubMed
    134. Soltesz I, Crunelli V. GABAA and pre- and post-synaptic GABAB receptor-mediated responses in the lateral geniculate nucleus. Prog Brain Res. 1992; 90:151-69. PMID: 1321458.
      View in: PubMed
    135. Leresche N, Lightowler S, Soltesz I, Jassik-Gerschenfeld D, Crunelli V. Low-frequency oscillatory activities intrinsic to rat and cat thalamocortical cells. J Physiol. 1991 Sep; 441:155-74. PMID: 1840071.
      View in: PubMed
    136. Soltesz I, Lightowler S, Leresche N, Jassik-Gerschenfeld D, Pollard CE, Crunelli V. Two inward currents and the transformation of low-frequency oscillations of rat and cat thalamocortical cells. J Physiol. 1991 Sep; 441:175-97. PMID: 1667794.
      View in: PubMed
    137. Leresche N, Jassik-Gerschenfeld D, Haby M, Soltesz I, Crunelli V. Pacemaker-like and other types of spontaneous membrane potential oscillations of thalamocortical cells. Neurosci Lett. 1990 May 18; 113(1):72-7. PMID: 1973275.
      View in: PubMed
    138. Soltesz I, Roberts JD, Takagi H, Richards JG, Mohler H, Somogyi P. Synaptic and Nonsynaptic Localization of Benzodiazepine/GABAA Receptor/Cl- Channel Complex Using Monoclonal Antibodies in the Dorsal Lateral Geniculate Nucleus of the Cat. Eur J Neurosci. 1990; 2(5):414-29. PMID: 12106029.
      View in: PubMed
    139. Freund TF, Martin KA, Soltesz I, Somogyi P, Whitteridge D. Arborisation pattern and postsynaptic targets of physiologically identified thalamocortical afferents in striate cortex of the macaque monkey. J Comp Neurol. 1989 Nov 08; 289(2):315-36. PMID: 2808770.
      View in: PubMed
    140. Soltesz I, Lightowler S, Leresche N, Crunelli V. Optic tract stimulation evokes GABAA but not GABAB IPSPs in the rat ventral lateral geniculate nucleus. Brain Res. 1989 Feb 06; 479(1):49-55. PMID: 2924152.
      View in: PubMed
    141. Soltesz I, Lightowler S, Leresche N, Crunelli V. On the properties and origin of the GABAB inhibitory postsynaptic potential recorded in morphologically identified projection cells of the cat dorsal lateral geniculate nucleus. Neuroscience. 1989; 33(1):23-33. PMID: 2557560.
      View in: PubMed
    142. Soltesz I, Haby M, Leresche N, Crunelli V. The GABAB antagonist phaclofen inhibits the late K+-dependent IPSP in cat and rat thalamic and hippocampal neurones. Brain Res. 1988 May 17; 448(2):351-4. PMID: 2837311.
      View in: PubMed
    143. Haby M, Leresche N, Jassik-Gerschenfeld D, Soltesz I, Crunelli V. [Spontaneous rhythmic depolarization in the principal cells of the lateral geniculate body in vitro: the role of NMDA receptors]. C R Acad Sci III. 1988; 306(5):195-9. PMID: 2830951.
      View in: PubMed