Pedersen, Irene

Title(s)Assistant Professor, Molecular Biology & Biochemistry
Phone(949) 824-2587
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    Collapse Research 
    Collapse Research Activities and Funding
    miR regulation of the neurovasculature function in health and disease
    NIH/NINDS R01NS107344Aug 1, 2018 - May 31, 2022
    Role: Principal Investigator
    Cooperation of PTEN and SHIP as tumor suppressors in B-Cells
    NIH/NCI K01CA122192Sep 30, 2007 - Aug 31, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Guzman H, Sanders K, Idica A, Bochnakian A, Jury D, Daugaard I, Zisoulis DG, Pedersen IM. miR-128 inhibits telomerase activity by targeting TERT mRNA. Oncotarget. 2018 Mar 02; 9(17):13244-13253. PMID: 29568354.
      View in: PubMed
    2. Idica A, Sevrioukov EA, Zisoulis DG, Hamdorf M, Daugaard I, Kadandale P, Pedersen IM. MicroRNA miR-128 represses LINE-1 (L1) retrotransposition by down-regulating the nuclear import factor TNPO1. J Biol Chem. 2017 12 15; 292(50):20494-20508. PMID: 28974576.
      View in: PubMed
    3. Riess M, Fuchs NV, Idica A, Hamdorf M, Flory E, Pedersen IM, K├Ânig R. Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a. J Biol Chem. 2017 Jan 06; 292(1):264-277. PMID: 27909056.
      View in: PubMed
    4. Pedersen IM, Zisoulis DG. Transposable elements and miRNA: Regulation of genomic stability and plasticity. Mob Genet Elements. 2016 May-Jun; 6(3):e1175537. PMID: 27511122; PMCID: PMC4964891 [Available on 04/08/17].
    5. Beasley SM, Plikus MV, Spitale RC, Pedersen IM. The emerging functions of regulatory RNA species in skin biology. Exp Dermatol. 2015 Nov; 24(11):827-8. PMID: 26309056; PMCID: PMC4715513 [Available on 11/01/16].
    6. Hamdorf M, Idica A, Zisoulis DG, Gamelin L, Martin C, Sanders KJ, Pedersen IM. miR-128 represses L1 retrotransposition by binding directly to L1 RNA. Nat Struct Mol Biol. 2015 Oct; 22(10):824-31. PMID: 26367248.
      View in: PubMed
    7. Pedersen IM, Otero D, Kao E, Miletic AV, Hother C, Ralfkiaer E, Rickert RC, Gronbaek K, David M. Onco-miR-155 targets SHIP1 to promote TNFalpha-dependent growth of B cell lymphomas. EMBO Mol Med. 2009 Aug; 1(5):288-95. PMID: 19890474.
      View in: PubMed
    8. Pedersen I, David M. MicroRNAs in the immune response. Cytokine. 2008 Sep; 43(3):391-4. PMID: 18701320; PMCID: PMC3642994.
    9. Boatright KM, Renatus M, Scott FL, Sperandio S, Shin H, Pedersen IM, Ricci JE, Edris WA, Sutherlin DP, Green DR, Salvesen GS. A unified model for apical caspase activation. Mol Cell. 2003 Feb; 11(2):529-41. PMID: 12620239.
      View in: PubMed
    10. Pedersen IM, Kitada S, Leoni LM, Zapata JM, Karras JG, Tsukada N, Kipps TJ, Choi YS, Bennett F, Reed JC. Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1. Blood. 2002 Sep 01; 100(5):1795-801. PMID: 12176902.
      View in: PubMed
    11. Chu P, Deforce D, Pedersen IM, Kim Y, Kitada S, Reed JC, Kipps TJ. Latent sensitivity to Fas-mediated apoptosis after CD40 ligation may explain activity of CD154 gene therapy in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3854-9. PMID: 11891278; PMCID: PMC122613.