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Pedersen, Irene

Title(s)Assistant Professor, Molecular Biology & Biochemistry
Phone(949) 824-2587
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    Collapse Research 
    Collapse Research Activities and Funding
    miR regulation of the neurovasculature function in health and disease
    NIH/NINDS R01NS107344Aug 1, 2018 - May 31, 2022
    Role: Principal Investigator
    Cooperation of PTEN and SHIP as tumor suppressors in B-Cells
    NIH/NCI K01CA122192Sep 30, 2007 - Aug 31, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bochnakian A, Zhen A, Zisoulis DG, Idica A, KewalRamani VN, Neel N, Daugaard I, Hamdorf M, Kitchen S, Lee K, Pedersen IM. Interferon-inducible miR-128 modulates HIV-1 replication by targeting TNPO3 mRNA. J Virol. 2019 Jul 24. PMID: 31341054.
      View in: PubMed
    2. Fung L, Guzman H, Sevrioukov E, Idica A, Park E, Bochnakian A, Daugaard I, Jury D, Mortazavi A, Zisoulis DG, Pedersen IM. miR-128 Restriction of LINE-1 (L1) Retrotransposition Is Dependent on Targeting hnRNPA1 mRNA. Int J Mol Sci. 2019 Apr 21; 20(8). PMID: 31010097.
      View in: PubMed
    3. Guzman H, Sanders K, Idica A, Bochnakian A, Jury D, Daugaard I, Zisoulis DG, Pedersen IM. miR-128 inhibits telomerase activity by targeting TERT mRNA. Oncotarget. 2018 Mar 02; 9(17):13244-13253. PMID: 29568354.
      View in: PubMed
    4. Idica A, Sevrioukov EA, Zisoulis DG, Hamdorf M, Daugaard I, Kadandale P, Pedersen IM. MicroRNA miR-128 represses LINE-1 (L1) retrotransposition by down-regulating the nuclear import factor TNPO1. J Biol Chem. 2017 12 15; 292(50):20494-20508. PMID: 28974576.
      View in: PubMed
    5. Daugaard I, Sanders KJ, Idica A, Vittayarukskul K, Hamdorf M, Krog JD, Chow R, Jury D, Hansen LL, Hager H, Lamy P, Choi CL, Agalliu D, Zisoulis DG, Pedersen IM. miR-151a induces partial EMT by regulating E-cadherin in NSCLC cells. Oncogenesis. 2017 Jul 31; 6(7):e366. PMID: 28759022.
      View in: PubMed
    6. Riess M, Fuchs NV, Idica A, Hamdorf M, Flory E, Pedersen IM, K├Ânig R. Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a. J Biol Chem. 2017 Jan 06; 292(1):264-277. PMID: 27909056.
      View in: PubMed
    7. Pedersen IM, Zisoulis DG. Transposable elements and miRNA: Regulation of genomic stability and plasticity. Mob Genet Elements. 2016 May-Jun; 6(3):e1175537. PMID: 27511122.
      View in: PubMed
    8. Beasley SM, Plikus MV, Spitale RC, Pedersen IM. The emerging functions of regulatory RNA species in skin biology. Exp Dermatol. 2015 Nov; 24(11):827-8. PMID: 26309056.
      View in: PubMed
    9. Hamdorf M, Idica A, Zisoulis DG, Gamelin L, Martin C, Sanders KJ, Pedersen IM. miR-128 represses L1 retrotransposition by binding directly to L1 RNA. Nat Struct Mol Biol. 2015 Oct; 22(10):824-31. PMID: 26367248.
      View in: PubMed
    10. Pedersen IM, Otero D, Kao E, Miletic AV, Hother C, Ralfkiaer E, Rickert RC, Gronbaek K, David M. Onco-miR-155 targets SHIP1 to promote TNFalpha-dependent growth of B cell lymphomas. EMBO Mol Med. 2009 Aug; 1(5):288-95. PMID: 19890474.
      View in: PubMed
    11. Pedersen I, David M. MicroRNAs in the immune response. Cytokine. 2008 Sep; 43(3):391-4. PMID: 18701320; PMCID: PMC3642994.
    12. Boatright KM, Renatus M, Scott FL, Sperandio S, Shin H, Pedersen IM, Ricci JE, Edris WA, Sutherlin DP, Green DR, Salvesen GS. A unified model for apical caspase activation. Mol Cell. 2003 Feb; 11(2):529-41. PMID: 12620239.
      View in: PubMed
    13. Pedersen IM, Kitada S, Leoni LM, Zapata JM, Karras JG, Tsukada N, Kipps TJ, Choi YS, Bennett F, Reed JC. Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1. Blood. 2002 Sep 01; 100(5):1795-801. PMID: 12176902.
      View in: PubMed
    14. Chu P, Deforce D, Pedersen IM, Kim Y, Kitada S, Reed JC, Kipps TJ. Latent sensitivity to Fas-mediated apoptosis after CD40 ligation may explain activity of CD154 gene therapy in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3854-9. PMID: 11891278; PMCID: PMC122613.