Ian Parker

Title(s)Professor, Non-SOM
SchoolNon-SOM Academic Affairs
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-7332
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    Collapse Research 
    Collapse Research Activities and Funding
    Multi-scale observation and modeling of IP3/Ca signaling
    NIH R01GM065830Aug 1, 2002 - Jun 30, 2018
    Role: Co-Principal Investigator
    Elementary Events of Intracellular Calcium Signaling
    NIH R37GM048071Aug 1, 1992 - Aug 31, 2021
    Role: Principal Investigator
    Elementary Events of Intracellular Calcium Signaling
    NIH R01GM048071Aug 1, 1992 - Aug 31, 2012
    Role: Principal Investigator
    INTRACELLULAR MESSENGER FUNCTIONS OF INOSITOL PHOSPHATES
    NIH R29GM039831Jul 1, 1988 - Jun 30, 1993
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. ER and SOCE Ca2+ signals are not required for directed cell migration in human iPSC-derived microglia. Cell Calcium. 2024 Nov; 123:102923. Granzotto A, McQuade A, Chadarevian JP, Davtyan H, Sensi SL, Parker I, Blurton-Jones M, Smith IF. PMID: 38970922.
      View in: PubMed   Mentions: 1     Fields:    
    2. ER and SOCE Ca2+ signals are not required for directed cell migration in human microglia. bioRxiv. 2024 Jan 19. Granzotto A, McQuade A, Chadarevian JP, Davtyan H, Sensi SL, Parker I, Blurton-Jones M, Smith I. PMID: 38293075; PMCID: PMC10827168.
      View in: PubMed   Mentions:
    3. PIEZO1-HaloTag hiPSCs: Bridging Molecular, Cellular and Tissue Imaging. bioRxiv. 2023 Dec 23. Bertaccini GA, Evans EL, Nourse JL, Dickinson GD, Liu G, Casanellas I, Seal S, Ly AT, Holt JR, Yan S, Hui EE, Panicker MM, Upadhyayula S, Parker I, Pathak MM. PMID: 38187535; PMCID: PMC10769387.
      View in: PubMed   Mentions:
    4. Intracellular Injection of Brain Extracts from Alzheimer's Disease Patients Triggers Unregulated Ca2+ Release from Intracellular Stores That Hinders Cellular Bioenergetics. Cells. 2022 11 16; 11(22). Pensalfini A, Umar AR, Glabe C, Parker I, Ullah G, Demuro A. PMID: 36429057; PMCID: PMC9688564.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. KRAP is required for diffuse and punctate IP3-mediated Ca2+ liberation and determines the number of functional IP3R channels within clusters. Cell Calcium. 2022 Nov; 107:102638. Vorontsova I, Lock JT, Parker I. PMID: 36030740; PMCID: PMC9588678.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    6. TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia. Elife. 2022 02 22; 11. Jairaman A, McQuade A, Granzotto A, Kang YJ, Chadarevian JP, Gandhi S, Parker I, Smith I, Cho H, Sensi SL, Othy S, Blurton-Jones M, Cahalan MD. PMID: 35191835; PMCID: PMC8906810.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    7. Termination of Ca2+ puffs during IP3-evoked global Ca2+ signals. Cell Calcium. 2021 12; 100:102494. Lock JT, Parker I. PMID: 34736161; PMCID: PMC9555318.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    8. Piezo1 channels restrain regulatory T cells but are dispensable for effector CD4+ T cell responses. Sci Adv. 2021 07; 7(28). Jairaman A, Othy S, Dynes JL, Yeromin AV, Zavala A, Greenberg ML, Nourse JL, Holt JR, Cahalan SM, Marangoni F, Parker I, Pathak MM, Cahalan MD. PMID: 34233878; PMCID: PMC8262815.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    9. Regulatory T cells suppress Th17 cell Ca2+ signaling in the spinal cord during murine autoimmune neuroinflammation. Proc Natl Acad Sci U S A. 2020 08 18; 117(33):20088-20099. Othy S, Jairaman A, Dynes JL, Dong TX, Tune C, Yeromin AV, Zavala A, Akunwafo C, Chen F, Parker I, Cahalan MD. PMID: 32732436; PMCID: PMC7443932.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    10. ER-luminal [Ca2+] regulation of InsP3 receptor gating mediated by an ER-luminal peripheral Ca2+-binding protein. Elife. 2020 05 18; 9. Vais H, Wang M, Mallilankaraman K, Payne R, McKennan C, Lock JT, Spruce LA, Fiest C, Chan MY, Parker I, Seeholzer SH, Foskett JK, Mak DD. PMID: 32420875; PMCID: PMC7259957.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    11. IP3 mediated global Ca2+ signals arise through two temporally and spatially distinct modes of Ca2+ release. Elife. 2020 05 12; 9. Lock JT, Parker I. PMID: 32396066; PMCID: PMC7253181.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    12. Noise analysis of cytosolic calcium image data. Cell Calcium. 2020 03; 86:102152. Swaminathan D, Dickinson GD, Demuro A, Parker I. PMID: 31918030; PMCID: PMC7384537.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    13. Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca2+ flickers. Commun Biol. 2019; 2:298. Ellefsen KL, Holt JR, Chang AC, Nourse JL, Arulmoli J, Mekhdjian AH, Abuwarda H, Tombola F, Flanagan LA, Dunn AR, Parker I, Pathak MM. PMID: 31396578; PMCID: PMC6685976.
      View in: PubMed   Mentions: 84  Translation:HumansAnimalsCells
    14. Spatial-temporal patterning of Ca2+ signals by the subcellular distribution of IP3 and IP3 receptors. Semin Cell Dev Biol. 2019 10; 94:3-10. Lock JT, Smith IF, Parker I. PMID: 30703557; PMCID: PMC6677640.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    15. All three IP3 receptor isoforms generate Ca2+ puffs that display similar characteristics. Sci Signal. 2018 12 18; 11(561). Lock JT, Alzayady KJ, Yule DI, Parker I. PMID: 30563861; PMCID: PMC6402561.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    16. Applications of FLIKA, a Python-based image processing and analysis platform, for studying local events of cellular calcium signaling. Biochim Biophys Acta Mol Cell Res. 2019 07; 1866(7):1171-1179. Ellefsen KL, Lock JT, Settle B, Karsten CA, Parker I. PMID: 30500432; PMCID: PMC6461507.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    17. CellSpecks: A Software for Automated Detection and Analysis of Calcium Channels in Live Cells. Biophys J. 2018 12 04; 115(11):2141-2151. Shah SI, Smith M, Swaminathan D, Parker I, Ullah G, Demuro A. PMID: 30447989; PMCID: PMC6289074.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    18. TraceSpecks: A Software for Automated Idealization of Noisy Patch-Clamp and Imaging Data. Biophys J. 2018 07 03; 115(1):9-21. Shah SI, Demuro A, Mak DD, Parker I, Pearson JE, Ullah G. PMID: 29972815; PMCID: PMC6035303.
      View in: PubMed   Mentions: 7     Fields:    
    19. CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes. Neuron. 2018 05 02; 98(3):547-561.e10. Ma Z, Taruno A, Ohmoto M, Jyotaki M, Lim JC, Miyazaki H, Niisato N, Marunaka Y, Lee RJ, Hoff H, Payne R, Demuro A, Parker I, Mitchell CH, Henao-Mejia J, Tanis JE, Matsumoto I, Tordoff MG, Foskett JK. PMID: 29681531; PMCID: PMC5934295.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    20. Intermittent Ca2+ signals mediated by Orai1 regulate basal T cell motility. Elife. 2017 12 14; 6. Dong TX, Othy S, Greenberg ML, Jairaman A, Akunwafo C, Leverrier S, Yu Y, Parker I, Dynes JL, Cahalan MD. PMID: 29239723; PMCID: PMC5747518.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    21. T-cell calcium dynamics visualized in a ratiometric tdTomato-GCaMP6f transgenic reporter mouse. Elife. 2017 12 14; 6. Dong TX, Othy S, Jairaman A, Skupsky J, Zavala A, Parker I, Dynes JL, Cahalan MD. PMID: 29239725; PMCID: PMC5747524.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    22. Dynamic Ca2+ imaging with a simplified lattice light-sheet microscope: A sideways view of subcellular Ca2+ puffs. Cell Calcium. 2018 05; 71:34-44. Ellefsen KL, Parker I. PMID: 29604962; PMCID: PMC5881921.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    23. Lattice light sheet imaging of membrane nanotubes between human breast cancer cells in culture and in brain metastases. Sci Rep. 2017 09 08; 7(1):11029. Parker I, Evans KT, Ellefsen K, Lawson DA, Smith IF. PMID: 28887508; PMCID: PMC5591308.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    24. High-throughput screen detects calcium signaling dysfunction in typical sporadic autism spectrum disorder. Sci Rep. 2017 02 01; 7:40740. Schmunk G, Nguyen RL, Ferguson DL, Kumar K, Parker I, Gargus JJ. PMID: 28145469; PMCID: PMC5286408.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    25. Comparison of Ca2+ puffs evoked by extracellular agonists and photoreleased IP3. Cell Calcium. 2017 05; 63:43-47. Lock JT, Smith IF, Parker I. PMID: 28108028; PMCID: PMC5459673.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    26. Hindered cytoplasmic diffusion of inositol trisphosphate restricts its cellular range of action. Sci Signal. 2016 11 08; 9(453):ra108. Dickinson GD, Ellefsen KL, Dawson SP, Pearson JE, Parker I. PMID: 27919026; PMCID: PMC5516629.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    27. Communication of Ca(2+) signals via tunneling membrane nanotubes is mediated by transmission of inositol trisphosphate through gap junctions. Cell Calcium. 2016 10; 60(4):266-72. Lock JT, Parker I, Smith IF. PMID: 27388952; PMCID: PMC5035603.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    28. A comparison of fluorescent Ca²⁺ indicators for imaging local Ca²⁺ signals in cultured cells. Cell Calcium. 2015 Dec; 58(6):638-48. Lock JT, Parker I, Smith IF. PMID: 26572560; PMCID: PMC4658286.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    29. Shared functional defect in IP₃R-mediated calcium signaling in diverse monogenic autism syndromes. Transl Psychiatry. 2015 Sep 22; 5:e643. Schmunk G, Boubion BJ, Smith IF, Parker I, Gargus JJ. PMID: 26393489; PMCID: PMC5068815.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    30. Analyzing and Modeling the Kinetics of Amyloid Beta Pores Associated with Alzheimer's Disease Pathology. PLoS One. 2015; 10(9):e0137357. Ullah G, Demuro A, Parker I, Pearson JE. PMID: 26348728; PMCID: PMC4562663.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    31. Spinning-Spot Shadowless TIRF Microscopy. PLoS One. 2015; 10(8):e0136055. Ellefsen KL, Dynes JL, Parker I. PMID: 26308212; PMCID: PMC4550233.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    32. Picomolar sensitivity to inositol trisphosphate in Xenopus oocytes. Cell Calcium. 2015 Nov; 58(5):511-7. Demuro A, Parker I. PMID: 26344104; PMCID: PMC4708890.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    33. Huntington's disease cerebrospinal fluid seeds aggregation of mutant huntingtin. Mol Psychiatry. 2015 Nov; 20(11):1286-93. Tan Z, Dai W, van Erp TG, Overman J, Demuro A, Digman MA, Hatami A, Albay R, Sontag EM, Potkin KT, Ling S, Macciardi F, Bunney WE, Long JD, Paulsen JS, Ringman JM, Parker I, Glabe C, Thompson LM, Chiu W, Potkin SG. PMID: 26100538; PMCID: PMC4718563.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    34. Imaging local Ca2+ signals in cultured mammalian cells. J Vis Exp. 2015 Mar 03; (97). Lock JT, Ellefsen KL, Settle B, Parker I, Smith IF. PMID: 25867132; PMCID: PMC4401178.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    35. Two-photon imaging of cellular dynamics in the mouse spinal cord. J Vis Exp. 2015 Feb 22; (96). Weinger JG, Greenberg ML, Matheu MP, Parker I, Walsh CM, Lane TE, Cahalan MD. PMID: 25742043; PMCID: PMC4354666.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    36. Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming. Nat Commun. 2015 Feb 05; 6:6219. Matheu MP, Othy S, Greenberg ML, Dong TX, Schuijs M, Deswarte K, Hammad H, Lambrecht BN, Parker I, Cahalan MD. PMID: 25653051; PMCID: PMC4347855.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    37. Molecular biophysics of Orai store-operated Ca2+ channels. Biophys J. 2015 Jan 20; 108(2):237-46. Amcheslavsky A, Wood ML, Yeromin AV, Parker I, Freites JA, Tobias DJ, Cahalan MD. PMID: 25606672; PMCID: PMC4302196.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    38. Modulation of elementary calcium release mediates a transition from puffs to waves in an IP3R cluster model. PLoS Comput Biol. 2015 Jan; 11(1):e1003965. Rückl M, Parker I, Marchant JS, Nagaiah C, Johenning FW, Rüdiger S. PMID: 25569772; PMCID: PMC4288706.
      View in: PubMed   Mentions: 11     Fields:    
    39. Fluorescence microscopy. Cold Spring Harb Protoc. 2014 Oct 01; 2014(10):pdb.top071795. Sanderson MJ, Smith I, Parker I, Bootman MD. PMID: 25275114; PMCID: PMC4711767.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimals
    40. Single-molecule tracking of inositol trisphosphate receptors reveals different motilities and distributions. Biophys J. 2014 Aug 19; 107(4):834-45. Smith IF, Swaminathan D, Dickinson GD, Parker I. PMID: 25140418; PMCID: PMC4142249.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    41. Termination of calcium puffs and coupled closings of inositol trisphosphate receptor channels. Cell Calcium. 2014 Sep; 56(3):157-68. Wiltgen SM, Dickinson GD, Swaminathan D, Parker I. PMID: 25016315; PMCID: PMC4162808.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    42. An algorithm for automated detection, localization and measurement of local calcium signals from camera-based imaging. Cell Calcium. 2014 Sep; 56(3):147-56. Ellefsen KL, Settle B, Parker I, Smith IF. PMID: 25047761; PMCID: PMC4162823.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    43. Two-photon imaging of remyelination of spinal cord axons by engrafted neural precursor cells in a viral model of multiple sclerosis. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):E2349-55. Greenberg ML, Weinger JG, Matheu MP, Carbajal KS, Parker I, Macklin WB, Lane TE, Cahalan MD. PMID: 24843159; PMCID: PMC4050611.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    44. Factors determining the recruitment of inositol trisphosphate receptor channels during calcium puffs. Biophys J. 2013 Dec 03; 105(11):2474-84. Dickinson GD, Parker I. PMID: 24314078; PMCID: PMC3853323.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    45. Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy. PLoS One. 2013; 8(3):e58033. Matheu MP, Teijaro JR, Walsh KB, Greenberg ML, Marsolais D, Parker I, Rosen H, Oldstone MB, Cahalan MD. PMID: 23533579; PMCID: PMC3606384.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    46. Orai1 function is essential for T cell homing to lymph nodes. J Immunol. 2013 Apr 01; 190(7):3197-206. Greenberg ML, Yu Y, Leverrier S, Zhang SL, Parker I, Cahalan MD. PMID: 23455504; PMCID: PMC3608704.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    47. Cytotoxicity of intracellular aβ42 amyloid oligomers involves Ca2+ release from the endoplasmic reticulum by stimulated production of inositol trisphosphate. J Neurosci. 2013 Feb 27; 33(9):3824-33. Demuro A, Parker I. PMID: 23447594; PMCID: PMC3708452.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    48. Temperature dependence of IP3-mediated local and global Ca2+ signals. Biophys J. 2013 Jan 22; 104(2):386-95. Dickinson GD, Parker I. PMID: 23442860; PMCID: PMC3552255.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    49. Structural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexins. J Biol Chem. 2013 Mar 01; 288(9):6140-53. Siebert AP, Ma Z, Grevet JD, Demuro A, Parker I, Foskett JK. PMID: 23300080; PMCID: PMC3585051.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    50. Cytosolic [Ca2+] regulation of InsP3-evoked puffs. Biochem J. 2013 Jan 01; 449(1):167-73. Yamasaki-Mann M, Demuro A, Parker I. PMID: 23035871; PMCID: PMC3718855.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    51. Multi-scale data-driven modeling and observation of calcium puffs. Cell Calcium. 2012 Aug; 52(2):152-60. Ullah G, Parker I, Mak DO, Pearson JE. PMID: 22682010; PMCID: PMC3560535.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    52. The probability of triggering calcium puffs is linearly related to the number of inositol trisphosphate receptors in a cluster. Biophys J. 2012 Apr 18; 102(8):1826-36. Dickinson GD, Swaminathan D, Parker I. PMID: 22768938; PMCID: PMC3328715.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    53. Toll-like receptor 4-activated B cells out-compete Toll-like receptor 9-activated B cells to establish peripheral immunological tolerance. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):E1258-66. Matheu MP, Su Y, Greenberg ML, Blanc CA, Parker I, Scott DW, Cahalan MD. PMID: 22511718; PMCID: PMC3356607.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    54. Timescales of IP(3)-evoked Ca(2+) spikes emerge from Ca(2+) puffs only at the cellular level. Biophys J. 2011 Dec 07; 101(11):2638-44. Thurley K, Smith IF, Tovey SC, Taylor CW, Parker I, Falcke M. PMID: 22261051; PMCID: PMC3297781.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    55. Single-channel Ca(2+) imaging implicates Aβ1-42 amyloid pores in Alzheimer's disease pathology. J Cell Biol. 2011 Oct 31; 195(3):515-24. Demuro A, Smith M, Parker I. PMID: 22024165; PMCID: PMC3206345.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    56. Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):17832-7. Demuro A, Penna A, Safrina O, Yeromin AV, Amcheslavsky A, Cahalan MD, Parker I. PMID: 21987805; PMCID: PMC3203769.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    57. Enhanced ER Ca2+ store filling by overexpression of SERCA2b promotes IP3-evoked puffs. Cell Calcium. 2011 Jul; 50(1):36-41. Yamasaki-Mann M, Parker I. PMID: 21616533; PMCID: PMC3138822.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    58. Active generation and propagation of Ca2+ signals within tunneling membrane nanotubes. Biophys J. 2011 Apr 20; 100(8):L37-9. Smith IF, Shuai J, Parker I. PMID: 21504718; PMCID: PMC3077701.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    59. Induction of an immune response for imaging antigen-presenting cell/T-cell interactions. Cold Spring Harb Protoc. 2011 Feb 01; 2011(2):pdb.prot5566. Matheu MP, Cahalan MD, Parker I. PMID: 21285266.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    60. In vivo lymph node imaging. Cold Spring Harb Protoc. 2011 Feb 01; 2011(2):pdb.prot5568. Matheu MP, Cahalan MD, Parker I. PMID: 21285268.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    61. Immunoimaging: studying immune system dynamics using two-photon microscopy. Cold Spring Harb Protoc. 2011 Feb 01; 2011(2):pdb.top99. Matheu MP, Cahalan MD, Parker I. PMID: 21285279.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    62. General approach to adoptive transfer and cell labeling for immunoimaging. Cold Spring Harb Protoc. 2011 Feb 01; 2011(2):pdb.prot5565. Matheu MP, Cahalan MD, Parker I. PMID: 21285265.
      View in: PubMed   Mentions: 3     Fields:    
    63. In situ lymph node imaging. Cold Spring Harb Protoc. 2011 Feb 01; 2011(2):pdb.prot5567. Matheu MP, Cahalan MD, Parker I. PMID: 21285267.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    64. Recording single-channel activity of inositol trisphosphate receptors in intact cells with a microscope, not a patch clamp. J Gen Physiol. 2010 Aug; 136(2):119-27. Parker I, Smith IF. PMID: 20660654; PMCID: PMC2912063.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    65. Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell. 2010 Jul 23; 142(2):270-83. Cárdenas C, Miller RA, Smith I, Bui T, Molgó J, Müller M, Vais H, Cheung KH, Yang J, Parker I, Thompson CB, Birnbaum MJ, Hallows KR, Foskett JK. PMID: 20655468; PMCID: PMC2911450.
      View in: PubMed   Mentions: 501     Fields:    Translation:AnimalsCells
    66. Superresolution localization of single functional IP3R channels utilizing Ca2+ flux as a readout. Biophys J. 2010 Jul 21; 99(2):437-46. Wiltgen SM, Smith IF, Parker I. PMID: 20643061; PMCID: PMC2905071.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    67. A novel postsynaptic mechanism for heterosynaptic sharing of short-term plasticity. J Neurosci. 2010 Jun 30; 30(26):8797-806. Reissner KJ, Pu L, Schaffhausen JH, Boyle HD, Smith IF, Parker I, Carew TJ. PMID: 20592201; PMCID: PMC2911352.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    68. Modulation of endoplasmic reticulum Ca2+ store filling by cyclic ADP-ribose promotes inositol trisphosphate (IP3)-evoked Ca2+ signals. J Biol Chem. 2010 Aug 06; 285(32):25053-61. Yamasaki-Mann M, Demuro A, Parker I. PMID: 20538594; PMCID: PMC2915741.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    69. Selective and site-specific mobilization of dermal dendritic cells and Langerhans cells by Th1- and Th2-polarizing adjuvants. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8334-9. Sen D, Forrest L, Kepler TB, Parker I, Cahalan MD. PMID: 20404167; PMCID: PMC2889549.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    70. Calcium signaling and amyloid toxicity in Alzheimer disease. J Biol Chem. 2010 Apr 23; 285(17):12463-8. Demuro A, Parker I, Stutzmann GE. PMID: 20212036; PMCID: PMC2857063.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansAnimalsCells
    71. NK cell patrolling and elimination of donor-derived dendritic cells favor indirect alloreactivity. J Immunol. 2010 Mar 01; 184(5):2329-36. Garrod KR, Liu FC, Forrest LE, Parker I, Kang SM, Cahalan MD. PMID: 20139277; PMCID: PMC3125519.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    72. Ca(2+) puffs originate from preestablished stable clusters of inositol trisphosphate receptors. Sci Signal. 2009 Nov 24; 2(98):ra77. Smith IF, Wiltgen SM, Shuai J, Parker I. PMID: 19934435; PMCID: PMC2897231.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    73. Acquisition of chemiluminescent signals from immunoblots with a digital single-lens reflex camera. Anal Biochem. 2010 Feb 01; 397(1):129-31. Khoury MK, Parker I, Aswad DW. PMID: 19788886; PMCID: PMC2808431.
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    74. Imaging the quantal substructure of single IP3R channel activity during Ca2+ puffs in intact mammalian cells. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6404-9. Smith IF, Parker I. PMID: 19332787; PMCID: PMC2669345.
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    75. cADPR stimulates SERCA activity in Xenopus oocytes. Cell Calcium. 2009 Mar; 45(3):293-9. Yamasaki-Mann M, Demuro A, Parker I. PMID: 19131109; PMCID: PMC2688955.
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    76. Chapter 16. Two-photon microscopy and multidimensional analysis of cell dynamics. Methods Enzymol. 2009; 461:349-78. Zinselmeyer BH, Dempster J, Wokosin DL, Cannon JJ, Pless R, Parker I, Miller MJ. PMID: 19480927.
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    77. Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block. Immunity. 2008 Oct 17; 29(4):602-14. Matheu MP, Beeton C, Garcia A, Chi V, Rangaraju S, Safrina O, Monaghan K, Uemura MI, Li D, Pal S, de la Maza LM, Monuki E, Flügel A, Pennington MW, Parker I, Chandy KG, Cahalan MD. PMID: 18835197; PMCID: PMC2732399.
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    78. Quantum dots for tracking dendritic cells and priming an immune response in vitro and in vivo. PLoS One. 2008 Sep 29; 3(9):e3290. Sen D, Deerinck TJ, Ellisman MH, Parker I, Cahalan MD. PMID: 18820727; PMCID: PMC2538605.
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    79. The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers. Nature. 2008 Nov 06; 456(7218):116-20. Penna A, Demuro A, Yeromin AV, Zhang SL, Safrina O, Parker I, Cahalan MD. PMID: 18820677; PMCID: PMC2597643.
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    80. Imaging effector memory T cells in the ear after induction of adoptive DTH. J Vis Exp. 2008 Aug 14; (18). Matheu MP, Beeton C, Parker I, Chandy KG, D Cahalan M. PMID: 19066497; PMCID: PMC3253563.
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    81. Modeling Ca2+ feedback on a single inositol 1,4,5-trisphosphate receptor and its modulation by Ca2+ buffers. Biophys J. 2008 Oct; 95(8):3738-52. Shuai J, Pearson JE, Parker I. PMID: 18641077; PMCID: PMC2553123.
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    82. Localization of puff sites adjacent to the plasma membrane: functional and spatial characterization of Ca2+ signaling in SH-SY5Y cells utilizing membrane-permeant caged IP3. Cell Calcium. 2009 Jan; 45(1):65-76. Smith IF, Wiltgen SM, Parker I. PMID: 18639334; PMCID: PMC2666303.
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    83. Generation of bone marrow derived murine dendritic cells for use in 2-photon imaging. J Vis Exp. 2008 Jul 09; (17). Matheu MP, Sen D, Cahalan MD, Parker I. PMID: 19066518; PMCID: PMC3278326.
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    84. SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. J Cell Biol. 2008 Jun 30; 181(7):1107-16. Green KN, Demuro A, Akbari Y, Hitt BD, Smith IF, Parker I, LaFerla FM. PMID: 18591429; PMCID: PMC2442205.
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    85. Choreography of cell motility and interaction dynamics imaged by two-photon microscopy in lymphoid organs. Annu Rev Immunol. 2008; 26:585-626. Cahalan MD, Parker I. PMID: 18173372; PMCID: PMC2732400.
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    86. Mode switching is the major mechanism of ligand regulation of InsP3 receptor calcium release channels. J Gen Physiol. 2007 Dec; 130(6):631-45. Ionescu L, White C, Cheung KH, Shuai J, Parker I, Pearson JE, Foskett JK, Mak DO. PMID: 17998395; PMCID: PMC2151663.
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    87. Lymphocyte cell motility: the twisting, turning tale of phosphoinositide 3-kinase. Biochem Soc Trans. 2007 Nov; 35(Pt 5):1109-13. Oak JS, Matheu MP, Parker I, Cahalan MD, Fruman DA. PMID: 17956290; PMCID: PMC2953540.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    88. Dissection and 2-photon imaging of peripheral lymph nodes in mice. J Vis Exp. 2007; (7):265. Matheu MP, Parker I, Cahalan MD. PMID: 18989436; PMCID: PMC2565854.
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    89. Multi-dimensional resolution of elementary Ca2+ signals by simultaneous multi-focal imaging. Cell Calcium. 2008 Apr; 43(4):367-74. Demuro A, Parker I. PMID: 17716727; PMCID: PMC2701662.
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    90. Class IA phosphoinositide 3-kinase modulates basal lymphocyte motility in the lymph node. J Immunol. 2007 Aug 15; 179(4):2261-9. Matheu MP, Deane JA, Parker I, Fruman DA, Cahalan MD. PMID: 17675487.
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    91. Ca2+ signals in CD4+ T cells during early contacts with antigen-bearing dendritic cells in lymph node. J Immunol. 2007 Aug 01; 179(3):1586-94. Wei SH, Safrina O, Yu Y, Garrod KR, Cahalan MD, Parker I. PMID: 17641025.
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    92. Natural killer cells actively patrol peripheral lymph nodes forming stable conjugates to eliminate MHC-mismatched targets. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12081-6. Garrod KR, Wei SH, Parker I, Cahalan MD. PMID: 17609379; PMCID: PMC1924574.
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    93. A kinetic model of single and clustered IP3 receptors in the absence of Ca2+ feedback. Biophys J. 2007 Aug 15; 93(4):1151-62. Shuai J, Pearson JE, Foskett JK, Mak DO, Parker I. PMID: 17526578; PMCID: PMC1929031.
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    94. Enhanced ryanodine-mediated calcium release in mutant PS1-expressing Alzheimer's mouse models. Ann N Y Acad Sci. 2007 Feb; 1097:265-77. Stutzmann GE, Smith I, Caccamo A, Oddo S, Parker I, Laferla F. PMID: 17413028.
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    95. Imaging single-channel calcium microdomains. Cell Calcium. 2006 Nov-Dec; 40(5-6):413-22. Demuro A, Parker I. PMID: 17067668; PMCID: PMC1694561.
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    96. 'Trigger' events precede calcium puffs in Xenopus oocytes. Biophys J. 2006 Dec 01; 91(11):4024-32. Rose HJ, Dargan S, Shuai J, Parker I. PMID: 16980363; PMCID: PMC1635674.
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    97. The number and spatial distribution of IP3 receptors underlying calcium puffs in Xenopus oocytes. Biophys J. 2006 Dec 01; 91(11):4033-44. Shuai J, Rose HJ, Parker I. PMID: 16980372; PMCID: PMC1635656.
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    98. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol. 2006 Aug; 2(8):434-41. Sanna MG, Wang SK, Gonzalez-Cabrera PJ, Don A, Marsolais D, Matheu MP, Wei SH, Parker I, Jo E, Cheng WC, Cahalan MD, Wong CH, Rosen H. PMID: 16829954.
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    99. Imaging the choreography of lymphocyte trafficking and the immune response. Curr Opin Immunol. 2006 Aug; 18(4):476-82. Cahalan MD, Parker I. PMID: 16765574; PMCID: PMC2749663.
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    100. Plasmalemmal Ca2+ signaling in arterial smooth muscle: it's elementary! J Gen Physiol. 2006 Jun; 127(6):605-9. Parker I. PMID: 16702356; PMCID: PMC2151537.
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    101. Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice. J Neurosci. 2006 May 10; 26(19):5180-9. Stutzmann GE, Smith I, Caccamo A, Oddo S, Laferla FM, Parker I. PMID: 16687509; PMCID: PMC6674246.
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    102. Analysis of puff dynamics in oocytes: interdependence of puff amplitude and interpuff interval. Biophys J. 2006 Jun 01; 90(11):3897-907. Fraiman D, Pando B, Dargan S, Parker I, Dawson SP. PMID: 16533853; PMCID: PMC1459518.
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    103. Imaging Ca2+ signals in Xenopus oocytes. Methods Mol Biol. 2006; 322:103-19. Dargan SL, Demuro A, Parker I. PMID: 16739719.
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    104. Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat Immunol. 2005 Dec; 6(12):1228-35. Wei SH, Rosen H, Matheu MP, Sanna MG, Wang SK, Jo E, Wong CH, Parker I, Cahalan MD. PMID: 16273098.
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    105. Close encounters of the first and second kind: T-DC and T-B interactions in the lymph node. Semin Immunol. 2005 Dec; 17(6):442-51. Cahalan MD, Parker I. PMID: 16263308; PMCID: PMC2953541.
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    106. "Optical patch-clamping": single-channel recording by imaging Ca2+ flux through individual muscle acetylcholine receptor channels. J Gen Physiol. 2005 Sep; 126(3):179-92. Demuro A, Parker I. PMID: 16103278; PMCID: PMC2266576.
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    107. In situ characterization of CD4+ T cell behavior in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance. J Exp Med. 2005 Jun 06; 201(11):1815-23. Zinselmeyer BH, Dempster J, Gurney AM, Wokosin D, Miller M, Ho H, Millington OR, Smith KM, Rush CM, Parker I, Cahalan M, Brewer JM, Garside P. PMID: 15928201; PMCID: PMC2213276.
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    108. Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol. 2005 Jun; 3(6):e150. Okada T, Miller MJ, Parker I, Krummel MF, Neighbors M, Hartley SB, O'Garra A, Cahalan MD, Cyster JG. PMID: 15857154; PMCID: PMC1088276.
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    109. Optical single-channel recording by imaging Ca2+ flux through individual ion channels: theoretical considerations and limits to resolution. Cell Calcium. 2005 Apr; 37(4):283-99. Shuai J, Parker I. PMID: 15755490.
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    110. Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers. J Biol Chem. 2005 Apr 29; 280(17):17294-300. Demuro A, Mina E, Kayed R, Milton SC, Parker I, Glabe CG. PMID: 15722360.
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    111. Dynamic multiphoton imaging: a live view from cells to systems. Physiology (Bethesda). 2005 Feb; 20:15-21. Stutzmann GE, Parker I. PMID: 15653835.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    112. A model-independent algorithm to derive Ca2+ fluxes underlying local cytosolic Ca2+ transients. Biophys J. 2005 Apr; 88(4):2403-21. Ventura AC, Bruno L, Demuro A, Parker I, Dawson SP. PMID: 15681645; PMCID: PMC1305340.
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    113. Two phases of zymogen granule lifetime in mouse pancreas: ghost granules linger after exocytosis of contents. J Physiol. 2005 Mar 01; 563(Pt 2):433-42. Thorn P, Parker I. PMID: 15637100; PMCID: PMC1665585.
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    114. Optical single-channel recording: imaging Ca2+ flux through individual ion channels with high temporal and spatial resolution. J Biomed Opt. 2005 Jan-Feb; 10(1):11002. Demuro A, Parker I. PMID: 15847568.
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    115. Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes. J Exp Med. 2004 Oct 04; 200(7):847-56. Miller MJ, Safrina O, Parker I, Cahalan MD. PMID: 15466619; PMCID: PMC2213293.
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    116. Imaging the activity and localization of single voltage-gated Ca(2+) channels by total internal reflection fluorescence microscopy. Biophys J. 2004 May; 86(5):3250-9. Demuro A, Parker I. PMID: 15111438; PMCID: PMC1304190.
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    117. Spatiotemporal patterning of IP3-mediated Ca2+ signals in Xenopus oocytes by Ca2+-binding proteins. J Physiol. 2004 Apr 15; 556(Pt 2):447-61. Dargan SL, Schwaller B, Parker I. PMID: 14755000; PMCID: PMC1664953.
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    118. Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability. J Neurosci. 2004 Jan 14; 24(2):508-13. Stutzmann GE, Caccamo A, LaFerla FM, Parker I. PMID: 14724250; PMCID: PMC6729995.
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    119. T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node. Proc Natl Acad Sci U S A. 2004 Jan 27; 101(4):998-1003. Miller MJ, Hejazi AS, Wei SH, Cahalan MD, Parker I. PMID: 14722354; PMCID: PMC327133.
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    120. Imaging single-channel calcium microdomains by total internal reflection microscopy. Biol Res. 2004; 37(4):675-9. Demuro A, Parker I. PMID: 15709697.
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    121. Optical single-channel recording: imaging Ca2+ flux through individual N-type voltage-gated channels expressed in Xenopus oocytes. Cell Calcium. 2003 Dec; 34(6):499-509. Demuro A, Parker I. PMID: 14572808.
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    122. Buffer kinetics shape the spatiotemporal patterns of IP3-evoked Ca2+ signals. J Physiol. 2003 Dec 15; 553(Pt 3):775-88. Dargan SL, Parker I. PMID: 14555715; PMCID: PMC2343635.
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    123. A stochastic view of lymphocyte motility and trafficking within the lymph node. Immunol Rev. 2003 Oct; 195:136-59. Wei SH, Parker I, Miller MJ, Cahalan MD. PMID: 12969316.
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    124. Real-time imaging of lymphocytes in vivo. Curr Opin Immunol. 2003 Aug; 15(4):372-7. Cahalan MD, Parker I, Wei SH, Miller MJ. PMID: 12900266; PMCID: PMC2953535.
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    125. Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2604-9. Miller MJ, Wei SH, Cahalan MD, Parker I. PMID: 12601158; PMCID: PMC151387.
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    126. Ca2+ signaling in mouse cortical neurons studied by two-photon imaging and photoreleased inositol triphosphate. J Neurosci. 2003 Feb 01; 23(3):758-65. Stutzmann GE, LaFerla FM, Parker I. PMID: 12574404; PMCID: PMC6741910.
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    127. Photonics for biologists. Methods Enzymol. 2003; 360:345-82. Parker I. PMID: 12622159.
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    128. Video-rate confocal microscopy. Methods Enzymol. 2003; 360:447-81. Sanderson MJ, Parker I. PMID: 12622163.
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    129. Cell biology of the human thiamine transporter-1 (hTHTR1). Intracellular trafficking and membrane targeting mechanisms. J Biol Chem. 2003 Feb 07; 278(6):3976-84. Subramanian VS, Marchant JS, Parker I, Said HM. PMID: 12454006.
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    130. Two-photon tissue imaging: seeing the immune system in a fresh light. Nat Rev Immunol. 2002 Nov; 2(11):872-80. Cahalan MD, Parker I, Wei SH, Miller MJ. PMID: 12415310; PMCID: PMC2749751.
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    131. Intracellular trafficking and membrane targeting mechanisms of the human reduced folate carrier in Mammalian epithelial cells. J Biol Chem. 2002 Sep 06; 277(36):33325-33. Marchant JS, Subramanian VS, Parker I, Said HM. PMID: 12087110.
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    132. Structural and functional relationships between Ca2+ puffs and mitochondria in Xenopus oocytes. Am J Physiol Cell Physiol. 2002 Jun; 282(6):C1374-86. Marchant JS, Ramos V, Parker I. PMID: 11997252.
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    133. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science. 2002 Jun 07; 296(5574):1869-73. Miller MJ, Wei SH, Parker I, Cahalan MD. PMID: 12016203.
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    134. Two-photon imaging in intact lymphoid tissue. Adv Exp Med Biol. 2002; 512:203-8. Wei SH, Miller MJ, Cahalan MD, Parker I. PMID: 12405205.
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    135. Construction of a two-photon microscope for video-rate Ca(2+) imaging. Cell Calcium. 2001 Dec; 30(6):383-93. Nguyen QT, Callamaras N, Hsieh C, Parker I. PMID: 11728133.
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    136. Multiphoton-evoked color change of DsRed as an optical highlighter for cellular and subcellular labeling. Nat Biotechnol. 2001 Jul; 19(7):645-9. Marchant JS, Stutzmann GE, Leissring MA, LaFerla FM, Parker I. PMID: 11433276.
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    137. Subcellular mechanisms of presenilin-mediated enhancement of calcium signaling. Neurobiol Dis. 2001 Jun; 8(3):469-78. Leissring MA, LaFerla FM, Callamaras N, Parker I. PMID: 11442355.
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    138. Xenopus tropicalis oocytes as an advantageous model system for the study of intracellular Ca(2+) signalling. Br J Pharmacol. 2001 Apr; 132(7):1396-410. Marchant JS, Parker I. PMID: 11264232; PMCID: PMC1572681.
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    139. Role of elementary Ca(2+) puffs in generating repetitive Ca(2+) oscillations. EMBO J. 2001 Jan 15; 20(1-2):65-76. Marchant JS, Parker I. PMID: 11226156; PMCID: PMC140189.
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    140. Functional interactions in Ca(2+) signaling over different time and distance scales. J Gen Physiol. 2000 Nov; 116(5):691-6. Marchant JS, Parker I. PMID: 11055997; PMCID: PMC2229487.
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    141. Calsenilin reverses presenilin-mediated enhancement of calcium signaling. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8590-3. Leissring MA, Yamasaki TR, Wasco W, Buxbaum JD, Parker I, LaFerla FM. PMID: 10900016; PMCID: PMC26992.
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    142. Phasic characteristic of elementary Ca(2+) release sites underlies quantal responses to IP(3). EMBO J. 2000 Jul 17; 19(14):3608-17. Callamaras N, Parker I. PMID: 10899115; PMCID: PMC313983.
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    143. Ca(2+)-dependent activation of Cl(-) currents in Xenopus oocytes is modulated by voltage. Am J Physiol Cell Physiol. 2000 Apr; 278(4):C667-75. Callamaras N, Parker I. PMID: 10751316.
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    144. Construction of a confocal microscope for real-time x-y and x-z imaging. Cell Calcium. 1999 Dec; 26(6):271-9. Callamaras N, Parker I. PMID: 10668565.
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    145. Presenilin-2 mutations modulate amplitude and kinetics of inositol 1, 4,5-trisphosphate-mediated calcium signals. J Biol Chem. 1999 Nov 12; 274(46):32535-8. Leissring MA, Parker I, LaFerla FM. PMID: 10551803.
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    146. Initiation of IP(3)-mediated Ca(2+) waves in Xenopus oocytes. EMBO J. 1999 Oct 01; 18(19):5285-99. Marchant J, Callamaras N, Parker I. PMID: 10508162; PMCID: PMC1171599.
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    147. Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes. J Neurochem. 1999 Mar; 72(3):1061-8. Leissring MA, Paul BA, Parker I, Cotman CW, LaFerla FM. PMID: 10037477.
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    148. Radial localization of inositol 1,4,5-trisphosphate-sensitive Ca2+ release sites in Xenopus oocytes resolved by axial confocal linescan imaging. J Gen Physiol. 1999 Feb; 113(2):199-213. Callamaras N, Parker I. PMID: 9925819; PMCID: PMC2223371.
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    149. Construction of line-scan confocal microscope for physiological recording. Methods Enzymol. 1999; 307:152-69. Callamaras N, Parker I. PMID: 10506973.
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    150. Hemispheric asymmetry of macroscopic and elementary calcium signals mediated by InsP3 in Xenopus oocytes. J Physiol. 1998 Sep 01; 511 ( Pt 2):395-405. Callamaras N, Sun XP, Ivorra I, Parker I. PMID: 9706018; PMCID: PMC2231135.
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    151. A continuum of InsP3-mediated elementary Ca2+ signalling events in Xenopus oocytes. J Physiol. 1998 May 15; 509 ( Pt 1):67-80. Sun XP, Callamaras N, Marchant JS, Parker I. PMID: 9547382; PMCID: PMC2230949.
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    152. Activation and co-ordination of InsP3-mediated elementary Ca2+ events during global Ca2+ signals in Xenopus oocytes. J Physiol. 1998 May 15; 509 ( Pt 1):81-91. Callamaras N, Marchant JS, Sun XP, Parker I. PMID: 9547383; PMCID: PMC2230929.
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    153. Caged inositol 1,4,5-trisphosphate for studying release of Ca2+ from intracellular stores. Methods Enzymol. 1998; 291:380-403. Callamaras N, Parker I. PMID: 9661160.
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    154. A high-resolution, confocal laser-scanning microscope and flash photolysis system for physiological studies. Cell Calcium. 1997 Jun; 21(6):441-52. Parker I, Callamaras N, Wier WG. PMID: 9223680.
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    155. Elementary events of InsP3-induced Ca2+ liberation in Xenopus oocytes: hot spots, puffs and blips. Cell Calcium. 1996 Aug; 20(2):105-21. Parker I, Choi J, Yao Y. PMID: 8889202.
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    156. Ca2+ transients associated with openings of inositol trisphosphate-gated channels in Xenopus oocytes. J Physiol. 1996 Mar 15; 491 ( Pt 3):663-8. Parker I, Yao Y. PMID: 8815201; PMCID: PMC1158808.
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    157. Fast kinetics of calcium liberation induced in Xenopus oocytes by photoreleased inositol trisphosphate. Biophys J. 1996 Jan; 70(1):222-37. Parker I, Yao Y, Ilyin V. PMID: 8770200; PMCID: PMC1224922.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    158. Quantal puffs of intracellular Ca2+ evoked by inositol trisphosphate in Xenopus oocytes. J Physiol. 1995 Feb 01; 482 ( Pt 3):533-53. Yao Y, Choi J, Parker I. PMID: 7738847; PMCID: PMC1157780.
      View in: PubMed   Mentions: 145     Fields:    Translation:AnimalsCells
    159. Calcium puffs in Xenopus oocytes. Ciba Found Symp. 1995; 188:50-60; discussion 60-5. Parker I, Yao Y. PMID: 7587623.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    160. Role of cytosolic Ca2+ in inhibition of InsP3-evoked Ca2+ release in Xenopus oocytes. J Physiol. 1994 Jun 15; 477 ( Pt 3):503-9. Ilyin V, Parker I. PMID: 7932238; PMCID: PMC1155614.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    161. Ca2+ influx modulation of temporal and spatial patterns of inositol trisphosphate-mediated Ca2+ liberation in Xenopus oocytes. J Physiol. 1994 Apr 01; 476(1):17-28. Yao Y, Parker I. PMID: 8046631; PMCID: PMC1160415.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    162. Relation between intracellular Ca2+ signals and Ca(2+)-activated Cl- current in Xenopus oocytes. Cell Calcium. 1994 Apr; 15(4):276-88. Parker I, Yao Y. PMID: 8055544.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    163. Inositol 1,4,5-trisphosphate receptors in Xenopus laevis oocytes: localization and modulation by Ca2+. Cell Calcium. 1994 Jan; 15(1):66-78. Callamaras N, Parker I. PMID: 8149406.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    164. Inositol trisphosphate-mediated Ca2+ influx into Xenopus oocytes triggers Ca2+ liberation from intracellular stores. J Physiol. 1993 Aug; 468:275-95. Yao Y, Parker I. PMID: 8254510; PMCID: PMC1143826.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    165. Confocal microfluorimetry of Ca2+ signals evoked in Xenopus oocytes by photoreleased inositol trisphosphate. J Physiol. 1993 Feb; 461:133-65. Parker I, Ivorra I. PMID: 8350261; PMCID: PMC1175250.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    166. Potentiation of inositol trisphosphate-induced Ca2+ mobilization in Xenopus oocytes by cytosolic Ca2+. J Physiol. 1992 Dec; 458:319-38. Yao Y, Parker I. PMID: 1284567; PMCID: PMC1175158.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    167. Characteristics of membrane currents evoked by photoreleased inositol trisphosphate in Xenopus oocytes. Am J Physiol. 1992 Jul; 263(1 Pt 1):C154-65. Parker I, Ivorra I. PMID: 1636674.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    168. Effects of alcohols on responses evoked by inositol trisphosphate in Xenopus oocytes. J Physiol. 1992 Mar; 448:339-54. Ilyin V, Parker I. PMID: 1375639; PMCID: PMC1176203.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    169. Messenger RNAs coding for receptors and channels in the cerebral cortex of adult and aged rats. Brain Res Mol Brain Res. 1992 Mar; 13(1-2):1-5. Carpenter MK, Parker I, Miledi R. PMID: 1374502.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    170. Regenerative release of calcium from functionally discrete subcellular stores by inositol trisphosphate. Proc Biol Sci. 1991 Dec 23; 246(1317):269-74. Parker I, Yao Y. PMID: 1686093.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    171. Microinjection into Xenopus oocytes: a precise semi-automatic instrument and optimal parameters for injection of mRNAs. J Biochem Biophys Methods. 1991 Apr; 22(3):243-52. Tigyi G, Parker I. PMID: 1865055.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    172. Receptors of the serotonin 1C subtype expressed from cloned DNA mediate the closing of K+ membrane channels encoded by brain mRNA. Proc Natl Acad Sci U S A. 1991 Mar 15; 88(6):2560-2. Panicker MM, Parker I, Miledi R. PMID: 2006190; PMCID: PMC51272.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    173. Inositol tetrakisphosphate liberates stored Ca2+ in Xenopus oocytes and facilitates responses to inositol trisphosphate. J Physiol. 1991 Feb; 433:207-27. Parker I, Ivorra I. PMID: 1841939; PMCID: PMC1181367.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    174. Caffeine inhibits inositol trisphosphate-mediated liberation of intracellular calcium in Xenopus oocytes. J Physiol. 1991 Feb; 433:229-40. Parker I, Ivorra I. PMID: 1844813; PMCID: PMC1181368.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    175. Inositol 1,3,4,6-tetrakisphosphate mobilizes calcium in Xenopus oocytes with high potency. Biochem J. 1991 Jan 15; 273(Pt 2):317-21. Ivorra I, Gigg R, Irvine RF, Parker I. PMID: 1991032; PMCID: PMC1149848.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    176. Localized all-or-none calcium liberation by inositol trisphosphate. Science. 1990 Nov 16; 250(4983):977-9. Parker I, Ivorra I. PMID: 2237441.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    177. Changes in messenger RNAs coding for neurotransmitter receptors and voltage-operated channels in the developing rat cerebral cortex. Dev Biol. 1990 Apr; 138(2):313-23. Carpenter MK, Parker I, Miledi R. PMID: 1690672.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    178. A slowly inactivating potassium current in native oocytes of Xenopus laevis. Proc R Soc Lond B Biol Sci. 1990 Jan 22; 238(1293):369-81. Parker I, Ivorra I. PMID: 1968644.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    179. Inhibition by Ca2+ of inositol trisphosphate-mediated Ca2+ liberation: a possible mechanism for oscillatory release of Ca2+. Proc Natl Acad Sci U S A. 1990 Jan; 87(1):260-4. Parker I, Ivorra I. PMID: 2296584; PMCID: PMC53242.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    180. Serotonin receptors expressed in Xenopus oocytes by mRNA from brain mediate a closing of K+ membrane channels. Brain Res Mol Brain Res. 1990 Jan; 7(1):31-8. Parker I, Panicker MM, Miledi R. PMID: 2153892.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    181. Nonlinearity and facilitation in phosphoinositide signaling studied by the use of caged inositol trisphosphate in Xenopus oocytes. J Neurosci. 1989 Nov; 9(11):4068-77. Parker I, Miledi R. PMID: 2555462; PMCID: PMC6569949.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    182. Membrane currents elicited by divalent cations in Xenopus oocytes. J Physiol. 1989 Oct; 417:173-95. Miledi R, Parker I, Woodward RM. PMID: 2482882; PMCID: PMC1189261.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    183. Ionic and charge-displacement currents evoked by temperature jumps in Xenopus oocytes. Proc R Soc Lond B Biol Sci. 1989 Aug 22; 237(1288):379-87. Parker I. PMID: 2571159.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    184. Latencies of membrane currents evoked in Xenopus oocytes by receptor activation, inositol trisphosphate and calcium. J Physiol. 1989 Aug; 415:189-210. Miledi R, Parker I. PMID: 2484206; PMCID: PMC1189173.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    185. Calcium transients evoked by electrical stimulation of smooth muscle from guinea-pig ileum recorded by the use of Fura-2. J Physiol. 1988 Dec; 407:117-34. Ito Y, Kuriyama H, Parker I. PMID: 3256613; PMCID: PMC1191194.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    186. Effect of tunicamycin on the expression of functional brain neurotransmitter receptors and voltage-operated channels in Xenopus oocytes. Brain Res. 1988 Nov; 464(3):191-9. Sumikawa K, Parker I, Miledi R. PMID: 2463055.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    187. Expression of GABA and glycine receptors by messenger RNAs from the developing rat cerebral cortex. Proc R Soc Lond B Biol Sci. 1988 Jul 22; 234(1275):159-70. Carpenter MK, Parker I, Miledi R. PMID: 2905459.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    188. Transient potassium current in native Xenopus oocytes. Proc R Soc Lond B Biol Sci. 1988 Jun 22; 234(1274):45-53. Parker I, Miledi R. PMID: 2457925.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    189. Expression of ACh-activated channels and sodium channels by messenger RNAs from innervated and denervated muscle. Proc R Soc Lond B Biol Sci. 1988 Apr 22; 233(1272):235-46. Parker I, Sumikawa K, Gundersen CB, Miledi R. PMID: 2454478.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    190. A calcium-independent chloride current activated by hyperpolarization in Xenopus oocytes. Proc R Soc Lond B Biol Sci. 1988 Mar 22; 233(1271):191-9. Parker I, Miledi R. PMID: 2454476.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    191. Responses to GABA, glycine and beta-alanine induced in Xenopus oocytes by messenger RNA from chick and rat brain. Proc R Soc Lond B Biol Sci. 1988 Mar 22; 233(1271):201-16. Parker I, Sumikawa K, Miledi R. PMID: 2898147.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    192. Tetrodotoxin-sensitive sodium current in native Xenopus oocytes. Proc R Soc Lond B Biol Sci. 1987 Dec 22; 232(1268):289-96. Parker I, Miledi R. PMID: 2449697.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    193. Injection of inositol 1,3,4,5-tetrakisphosphate into Xenopus oocytes generates a chloride current dependent upon intracellular calcium. Proc R Soc Lond B Biol Sci. 1987 Oct 22; 232(1266):59-70. Parker I, Miledi R. PMID: 2446333.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
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