Parker, Ian

InstitutionUniversity of California, Irvine
DepartmentNeurobiology & Behavior
Address1217 McGaugh Hall
Zot 4550
Irvine CA 92697
Phone(949) 824-7332, 7833
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    Collapse Research 
    Collapse Research Activities and Funding
    Multi-scale observation and modeling of IP3/Ca signaling
    NIH/NIGMS R01GM065830Aug 1, 2002 - Nov 30, 2017
    Role: Co-Principal Investigator
    Elementary Events of Intracellular Calcium Signaling
    NIH/NIGMS R37GM048071Aug 1, 1992 - Aug 31, 2021
    Role: Principal Investigator
    Elementary Events of Intracellular Calcium Signaling
    NIH/NIGMS R01GM048071Aug 1, 1992 - Aug 31, 2012
    Role: Principal Investigator
    NIH/NIGMS R29GM039831Jul 1, 1988 - Jun 30, 1993
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Shah SI, Demuro A, Mak DD, Parker I, Pearson JE, Ullah G. TraceSpecks: A Software for Automated Idealization of Noisy Patch-Clamp and Imaging Data. Biophys J. 2018 Jul 03; 115(1):9-21. PMID: 29972815.
      View in: PubMed
    2. Ma Z, Taruno A, Ohmoto M, Jyotaki M, Lim JC, Miyazaki H, Niisato N, Marunaka Y, Lee RJ, Hoff H, Payne R, Demuro A, Parker I, Mitchell CH, Henao-Mejia J, Tanis JE, Matsumoto I, Tordoff MG, Foskett JK. CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes. Neuron. 2018 May 02; 98(3):547-561.e10. PMID: 29681531.
      View in: PubMed
    3. Dong TX, Othy S, Greenberg ML, Jairaman A, Akunwafo C, Leverrier S, Yu Y, Parker I, Dynes JL, Cahalan MD. Intermittent Ca2+ signals mediated by Orai1 regulate basal T cell motility. Elife. 2017 12 14; 6. PMID: 29239723.
      View in: PubMed
    4. Dong TX, Othy S, Jairaman A, Skupsky J, Zavala A, Parker I, Dynes JL, Cahalan MD. T-cell calcium dynamics visualized in a ratiometric tdTomato-GCaMP6f transgenic reporter mouse. Elife. 2017 12 14; 6. PMID: 29239725.
      View in: PubMed
    5. Ellefsen KL, Parker I. Dynamic Ca2+ imaging with a simplified lattice light-sheet microscope: A sideways view of subcellular Ca2+ puffs. Cell Calcium. 2018 May; 71:34-44. PMID: 29604962.
      View in: PubMed
    6. Parker I, Evans KT, Ellefsen K, Lawson DA, Smith IF. Lattice light sheet imaging of membrane nanotubes between human breast cancer cells in culture and in brain metastases. Sci Rep. 2017 Sep 08; 7(1):11029. PMID: 28887508.
      View in: PubMed
    7. Schmunk G, Nguyen RL, Ferguson DL, Kumar K, Parker I, Gargus JJ. High-throughput screen detects calcium signaling dysfunction in typical sporadic autism spectrum disorder. Sci Rep. 2017 Feb 01; 7:40740. PMID: 28145469.
      View in: PubMed
    8. Lock JT, Smith IF, Parker I. Comparison of Ca2+ puffs evoked by extracellular agonists and photoreleased IP3. Cell Calcium. 2017 05; 63:43-47. PMID: 28108028.
      View in: PubMed
    9. Dickinson GD, Ellefsen KL, Dawson SP, Pearson JE, Parker I. Hindered cytoplasmic diffusion of inositol trisphosphate restricts its cellular range of action. Sci Signal. 2016 11 08; 9(453):ra108. PMID: 27919026.
      View in: PubMed
    10. Lock JT, Parker I, Smith IF. Communication of Ca(2+) signals via tunneling membrane nanotubes is mediated by transmission of inositol trisphosphate through gap junctions. Cell Calcium. 2016 10; 60(4):266-72. PMID: 27388952.
      View in: PubMed
    11. Lock JT, Parker I, Smith IF. A comparison of fluorescent Ca²? indicators for imaging local Ca²? signals in cultured cells. Cell Calcium. 2015 Dec; 58(6):638-48. PMID: 26572560; PMCID: PMC4658286 [Available on 12/01/16].
    12. Ullah G, Demuro A, Parker I, Pearson JE. Analyzing and Modeling the Kinetics of Amyloid Beta Pores Associated with Alzheimer's Disease Pathology. PLoS One. 2015; 10(9):e0137357. PMID: 26348728; PMCID: PMC4562663.
    13. Ellefsen KL, Dynes JL, Parker I. Spinning-Spot Shadowless TIRF Microscopy. PLoS One. 2015; 10(8):e0136055. PMID: 26308212; PMCID: PMC4550233.
    14. Demuro A, Parker I. Picomolar sensitivity to inositol trisphosphate in Xenopus oocytes. Cell Calcium. 2015 Nov; 58(5):511-7. PMID: 26344104; PMCID: PMC4708890 [Available on 11/01/16].
    15. Lock JT, Ellefsen KL, Settle B, Parker I, Smith IF. Imaging local Ca2+ signals in cultured mammalian cells. J Vis Exp. 2015 Mar 03; (97). PMID: 25867132; PMCID: PMC4401178.
    16. Weinger JG, Greenberg ML, Matheu MP, Parker I, Walsh CM, Lane TE, Cahalan MD. Two-photon imaging of cellular dynamics in the mouse spinal cord. J Vis Exp. 2015 Feb 22; (96). PMID: 25742043; PMCID: PMC4354666.
    17. Matheu MP, Othy S, Greenberg ML, Dong TX, Schuijs M, Deswarte K, Hammad H, Lambrecht BN, Parker I, Cahalan MD. Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming. Nat Commun. 2015 Feb 05; 6:6219. PMID: 25653051; PMCID: PMC4347855.
    18. Amcheslavsky A, Wood ML, Yeromin AV, Parker I, Freites JA, Tobias DJ, Cahalan MD. Molecular biophysics of Orai store-operated Ca2+ channels. Biophys J. 2015 Jan 20; 108(2):237-46. PMID: 25606672; PMCID: PMC4302196.
    19. Rückl M, Parker I, Marchant JS, Nagaiah C, Johenning FW, Rüdiger S. Modulation of elementary calcium release mediates a transition from puffs to waves in an IP3R cluster model. PLoS Comput Biol. 2015 Jan; 11(1):e1003965. PMID: 25569772; PMCID: PMC4288706.
    20. Sanderson MJ, Smith I, Parker I, Bootman MD. Fluorescence microscopy. Cold Spring Harb Protoc. 2014 Oct 01; 2014(10):pdb.top071795. PMID: 25275114; PMCID: PMC4711767.
    21. Smith IF, Swaminathan D, Dickinson GD, Parker I. Single-molecule tracking of inositol trisphosphate receptors reveals different motilities and distributions. Biophys J. 2014 Aug 19; 107(4):834-45. PMID: 25140418; PMCID: PMC4142249.
    22. Wiltgen SM, Dickinson GD, Swaminathan D, Parker I. Termination of calcium puffs and coupled closings of inositol trisphosphate receptor channels. Cell Calcium. 2014 Sep; 56(3):157-68. PMID: 25016315; PMCID: PMC4162808.
    23. Ellefsen KL, Settle B, Parker I, Smith IF. An algorithm for automated detection, localization and measurement of local calcium signals from camera-based imaging. Cell Calcium. 2014 Sep; 56(3):147-56. PMID: 25047761; PMCID: PMC4162823.
    24. Greenberg ML, Weinger JG, Matheu MP, Carbajal KS, Parker I, Macklin WB, Lane TE, Cahalan MD. Two-photon imaging of remyelination of spinal cord axons by engrafted neural precursor cells in a viral model of multiple sclerosis. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):E2349-55. PMID: 24843159; PMCID: PMC4050611.
    25. Dickinson GD, Parker I. Factors determining the recruitment of inositol trisphosphate receptor channels during calcium puffs. Biophys J. 2013 Dec 03; 105(11):2474-84. PMID: 24314078; PMCID: PMC3853323.
    26. Matheu MP, Teijaro JR, Walsh KB, Greenberg ML, Marsolais D, Parker I, Rosen H, Oldstone MB, Cahalan MD. Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy. PLoS One. 2013; 8(3):e58033. PMID: 23533579; PMCID: PMC3606384.
    27. Greenberg ML, Yu Y, Leverrier S, Zhang SL, Parker I, Cahalan MD. Orai1 function is essential for T cell homing to lymph nodes. J Immunol. 2013 Apr 01; 190(7):3197-206. PMID: 23455504; PMCID: PMC3608704.
    28. Demuro A, Parker I. Cytotoxicity of intracellular aß42 amyloid oligomers involves Ca2+ release from the endoplasmic reticulum by stimulated production of inositol trisphosphate. J Neurosci. 2013 Feb 27; 33(9):3824-33. PMID: 23447594; PMCID: PMC3708452.
    29. Dickinson GD, Parker I. Temperature dependence of IP3-mediated local and global Ca2+ signals. Biophys J. 2013 Jan 22; 104(2):386-95. PMID: 23442860; PMCID: PMC3552255.
    30. Siebert AP, Ma Z, Grevet JD, Demuro A, Parker I, Foskett JK. Structural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexins. J Biol Chem. 2013 Mar 01; 288(9):6140-53. PMID: 23300080; PMCID: PMC3585051.
    31. Yamasaki-Mann M, Demuro A, Parker I. Cytosolic [Ca2+] regulation of InsP3-evoked puffs. Biochem J. 2013 Jan 01; 449(1):167-73. PMID: 23035871; PMCID: PMC3718855.
    32. Ullah G, Parker I, Mak DO, Pearson JE. Multi-scale data-driven modeling and observation of calcium puffs. Cell Calcium. 2012 Aug; 52(2):152-60. PMID: 22682010; PMCID: PMC3560535.
    33. Dickinson GD, Swaminathan D, Parker I. The probability of triggering calcium puffs is linearly related to the number of inositol trisphosphate receptors in a cluster. Biophys J. 2012 Apr 18; 102(8):1826-36. PMID: 22768938; PMCID: PMC3328715.
    34. Matheu MP, Su Y, Greenberg ML, Blanc CA, Parker I, Scott DW, Cahalan MD. Toll-like receptor 4-activated B cells out-compete Toll-like receptor 9-activated B cells to establish peripheral immunological tolerance. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):E1258-66. PMID: 22511718; PMCID: PMC3356607.
    35. Thurley K, Smith IF, Tovey SC, Taylor CW, Parker I, Falcke M. Timescales of IP(3)-evoked Ca(2+) spikes emerge from Ca(2+) puffs only at the cellular level. Biophys J. 2011 Dec 07; 101(11):2638-44. PMID: 22261051; PMCID: PMC3297781.
    36. Demuro A, Smith M, Parker I. Single-channel Ca(2+) imaging implicates Aß1-42 amyloid pores in Alzheimer's disease pathology. J Cell Biol. 2011 Oct 31; 195(3):515-24. PMID: 22024165; PMCID: PMC3206345.
    37. Demuro A, Penna A, Safrina O, Yeromin AV, Amcheslavsky A, Cahalan MD, Parker I. Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):17832-7. PMID: 21987805; PMCID: PMC3203769.
    38. Yamasaki-Mann M, Parker I. Enhanced ER Ca2+ store filling by overexpression of SERCA2b promotes IP3-evoked puffs. Cell Calcium. 2011 Jul; 50(1):36-41. PMID: 21616533; PMCID: PMC3138822.
    39. Smith IF, Shuai J, Parker I. Active generation and propagation of Ca2+ signals within tunneling membrane nanotubes. Biophys J. 2011 Apr 20; 100(8):L37-9. PMID: 21504718; PMCID: PMC3077701.
    40. Matheu MP, Cahalan MD, Parker I. General approach to adoptive transfer and cell labeling for immunoimaging. Cold Spring Harb Protoc. 2011 Feb 01; 2011(2):pdb.prot5565. PMID: 21285265.
      View in: PubMed
    41. Matheu MP, Cahalan MD, Parker I. Immunoimaging: studying immune system dynamics using two-photon microscopy. Cold Spring Harb Protoc. 2011 Feb 01; 2011(2):pdb.top99. PMID: 21285279.
      View in: PubMed
    42. Matheu MP, Cahalan MD, Parker I. Induction of an immune response for imaging antigen-presenting cell/T-cell interactions. Cold Spring Harb Protoc. 2011 Feb 01; 2011(2):pdb.prot5566. PMID: 21285266.
      View in: PubMed
    43. Matheu MP, Cahalan MD, Parker I. In vivo lymph node imaging. Cold Spring Harb Protoc. 2011 Feb 01; 2011(2):pdb.prot5568. PMID: 21285268.
      View in: PubMed
    44. Matheu MP, Cahalan MD, Parker I. In situ lymph node imaging. Cold Spring Harb Protoc. 2011 Feb 01; 2011(2):pdb.prot5567. PMID: 21285267.
      View in: PubMed
    45. Parker I, Smith IF. Recording single-channel activity of inositol trisphosphate receptors in intact cells with a microscope, not a patch clamp. J Gen Physiol. 2010 Aug; 136(2):119-27. PMID: 20660654; PMCID: PMC2912063.
    46. Cárdenas C, Miller RA, Smith I, Bui T, Molgó J, Müller M, Vais H, Cheung KH, Yang J, Parker I, Thompson CB, Birnbaum MJ, Hallows KR, Foskett JK. Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell. 2010 Jul 23; 142(2):270-83. PMID: 20655468; PMCID: PMC2911450.
    47. Wiltgen SM, Smith IF, Parker I. Superresolution localization of single functional IP3R channels utilizing Ca2+ flux as a readout. Biophys J. 2010 Jul 21; 99(2):437-46. PMID: 20643061; PMCID: PMC2905071.
    48. Reissner KJ, Pu L, Schaffhausen JH, Boyle HD, Smith IF, Parker I, Carew TJ. A novel postsynaptic mechanism for heterosynaptic sharing of short-term plasticity. J Neurosci. 2010 Jun 30; 30(26):8797-806. PMID: 20592201; PMCID: PMC2911352.
    49. Yamasaki-Mann M, Demuro A, Parker I. Modulation of endoplasmic reticulum Ca2+ store filling by cyclic ADP-ribose promotes inositol trisphosphate (IP3)-evoked Ca2+ signals. J Biol Chem. 2010 Aug 06; 285(32):25053-61. PMID: 20538594; PMCID: PMC2915741.
    50. Sen D, Forrest L, Kepler TB, Parker I, Cahalan MD. Selective and site-specific mobilization of dermal dendritic cells and Langerhans cells by Th1- and Th2-polarizing adjuvants. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8334-9. PMID: 20404167; PMCID: PMC2889549.
    51. Demuro A, Parker I, Stutzmann GE. Calcium signaling and amyloid toxicity in Alzheimer disease. J Biol Chem. 2010 Apr 23; 285(17):12463-8. PMID: 20212036; PMCID: PMC2857063.
    52. Garrod KR, Liu FC, Forrest LE, Parker I, Kang SM, Cahalan MD. NK cell patrolling and elimination of donor-derived dendritic cells favor indirect alloreactivity. J Immunol. 2010 Mar 01; 184(5):2329-36. PMID: 20139277; PMCID: PMC3125519.
    53. Smith IF, Wiltgen SM, Shuai J, Parker I. Ca(2+) puffs originate from preestablished stable clusters of inositol trisphosphate receptors. Sci Signal. 2009 Nov 24; 2(98):ra77. PMID: 19934435; PMCID: PMC2897231.
    54. Khoury MK, Parker I, Aswad DW. Acquisition of chemiluminescent signals from immunoblots with a digital single-lens reflex camera. Anal Biochem. 2010 Feb 01; 397(1):129-31. PMID: 19788886; PMCID: PMC2808431.
    55. Smith IF, Parker I. Imaging the quantal substructure of single IP3R channel activity during Ca2+ puffs in intact mammalian cells. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6404-9. PMID: 19332787; PMCID: PMC2669345.
    56. Yamasaki-Mann M, Demuro A, Parker I. cADPR stimulates SERCA activity in Xenopus oocytes. Cell Calcium. 2009 Mar; 45(3):293-9. PMID: 19131109; PMCID: PMC2688955.
    57. Zinselmeyer BH, Dempster J, Wokosin DL, Cannon JJ, Pless R, Parker I, Miller MJ. Chapter 16. Two-photon microscopy and multidimensional analysis of cell dynamics. Methods Enzymol. 2009; 461:349-78. PMID: 19480927.
      View in: PubMed
    58. Matheu MP, Beeton C, Garcia A, Chi V, Rangaraju S, Safrina O, Monaghan K, Uemura MI, Li D, Pal S, de la Maza LM, Monuki E, Flügel A, Pennington MW, Parker I, Chandy KG, Cahalan MD. Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block. Immunity. 2008 Oct 17; 29(4):602-14. PMID: 18835197; PMCID: PMC2732399.
    59. Sen D, Deerinck TJ, Ellisman MH, Parker I, Cahalan MD. Quantum dots for tracking dendritic cells and priming an immune response in vitro and in vivo. PLoS One. 2008 Sep 29; 3(9):e3290. PMID: 18820727; PMCID: PMC2538605.
    60. Penna A, Demuro A, Yeromin AV, Zhang SL, Safrina O, Parker I, Cahalan MD. The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers. Nature. 2008 Nov 06; 456(7218):116-20. PMID: 18820677; PMCID: PMC2597643.
    61. Matheu MP, Beeton C, Parker I, Chandy KG, D Cahalan M. Imaging effector memory T cells in the ear after induction of adoptive DTH. J Vis Exp. 2008 Aug 14; (18). PMID: 19066497; PMCID: PMC3253563.
    62. Shuai J, Pearson JE, Parker I. Modeling Ca2+ feedback on a single inositol 1,4,5-trisphosphate receptor and its modulation by Ca2+ buffers. Biophys J. 2008 Oct; 95(8):3738-52. PMID: 18641077; PMCID: PMC2553123.
    63. Smith IF, Wiltgen SM, Parker I. Localization of puff sites adjacent to the plasma membrane: functional and spatial characterization of Ca2+ signaling in SH-SY5Y cells utilizing membrane-permeant caged IP3. Cell Calcium. 2009 Jan; 45(1):65-76. PMID: 18639334; PMCID: PMC2666303.
    64. Matheu MP, Sen D, Cahalan MD, Parker I. Generation of bone marrow derived murine dendritic cells for use in 2-photon imaging. J Vis Exp. 2008 Jul 09; (17). PMID: 19066518; PMCID: PMC3278326.
    65. Green KN, Demuro A, Akbari Y, Hitt BD, Smith IF, Parker I, LaFerla FM. SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. J Cell Biol. 2008 Jun 30; 181(7):1107-16. PMID: 18591429; PMCID: PMC2442205.
    66. Cahalan MD, Parker I. Choreography of cell motility and interaction dynamics imaged by two-photon microscopy in lymphoid organs. Annu Rev Immunol. 2008; 26:585-626. PMID: 18173372; PMCID: PMC2732400.
    67. Ionescu L, White C, Cheung KH, Shuai J, Parker I, Pearson JE, Foskett JK, Mak DO. Mode switching is the major mechanism of ligand regulation of InsP3 receptor calcium release channels. J Gen Physiol. 2007 Dec; 130(6):631-45. PMID: 17998395; PMCID: PMC2151663.
    68. Matheu MP, Parker I, Cahalan MD. Dissection and 2-photon imaging of peripheral lymph nodes in mice. J Vis Exp. 2007; (7):265. PMID: 18989436; PMCID: PMC2565854.
    69. Demuro A, Parker I. Multi-dimensional resolution of elementary Ca2+ signals by simultaneous multi-focal imaging. Cell Calcium. 2008 Apr; 43(4):367-74. PMID: 17716727; PMCID: PMC2701662.
    70. Matheu MP, Deane JA, Parker I, Fruman DA, Cahalan MD. Class IA phosphoinositide 3-kinase modulates basal lymphocyte motility in the lymph node. J Immunol. 2007 Aug 15; 179(4):2261-9. PMID: 17675487.
      View in: PubMed
    71. Wei SH, Safrina O, Yu Y, Garrod KR, Cahalan MD, Parker I. Ca2+ signals in CD4+ T cells during early contacts with antigen-bearing dendritic cells in lymph node. J Immunol. 2007 Aug 01; 179(3):1586-94. PMID: 17641025.
      View in: PubMed
    72. Garrod KR, Wei SH, Parker I, Cahalan MD. Natural killer cells actively patrol peripheral lymph nodes forming stable conjugates to eliminate MHC-mismatched targets. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12081-6. PMID: 17609379; PMCID: PMC1924574.
    73. Shuai J, Pearson JE, Foskett JK, Mak DO, Parker I. A kinetic model of single and clustered IP3 receptors in the absence of Ca2+ feedback. Biophys J. 2007 Aug 15; 93(4):1151-62. PMID: 17526578; PMCID: PMC1929031.
    74. Stutzmann GE, Smith I, Caccamo A, Oddo S, Parker I, Laferla F. Enhanced ryanodine-mediated calcium release in mutant PS1-expressing Alzheimer's mouse models. Ann N Y Acad Sci. 2007 Feb; 1097:265-77. PMID: 17413028.
      View in: PubMed
    75. Demuro A, Parker I. Imaging single-channel calcium microdomains. Cell Calcium. 2006 Nov-Dec; 40(5-6):413-22. PMID: 17067668; PMCID: PMC1694561.
    76. Shuai J, Rose HJ, Parker I. The number and spatial distribution of IP3 receptors underlying calcium puffs in Xenopus oocytes. Biophys J. 2006 Dec 01; 91(11):4033-44. PMID: 16980372; PMCID: PMC1635656.
    77. Rose HJ, Dargan S, Shuai J, Parker I. 'Trigger' events precede calcium puffs in Xenopus oocytes. Biophys J. 2006 Dec 01; 91(11):4024-32. PMID: 16980363; PMCID: PMC1635674.
    78. Sanna MG, Wang SK, Gonzalez-Cabrera PJ, Don A, Marsolais D, Matheu MP, Wei SH, Parker I, Jo E, Cheng WC, Cahalan MD, Wong CH, Rosen H. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol. 2006 Aug; 2(8):434-41. PMID: 16829954.
      View in: PubMed
    79. Cahalan MD, Parker I. Imaging the choreography of lymphocyte trafficking and the immune response. Curr Opin Immunol. 2006 Aug; 18(4):476-82. PMID: 16765574; PMCID: PMC2749663.
    80. Parker I. Plasmalemmal Ca2+ signaling in arterial smooth muscle: it's elementary! J Gen Physiol. 2006 Jun; 127(6):605-9. PMID: 16702356; PMCID: PMC2151537.
    81. Stutzmann GE, Smith I, Caccamo A, Oddo S, Laferla FM, Parker I. Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice. J Neurosci. 2006 May 10; 26(19):5180-9. PMID: 16687509.
      View in: PubMed
    82. Fraiman D, Pando B, Dargan S, Parker I, Dawson SP. Analysis of puff dynamics in oocytes: interdependence of puff amplitude and interpuff interval. Biophys J. 2006 Jun 01; 90(11):3897-907. PMID: 16533853; PMCID: PMC1459518.
    83. Dargan SL, Demuro A, Parker I. Imaging Ca2+ signals in Xenopus oocytes. Methods Mol Biol. 2006; 322:103-19. PMID: 16739719.
      View in: PubMed
    84. Wei SH, Rosen H, Matheu MP, Sanna MG, Wang SK, Jo E, Wong CH, Parker I, Cahalan MD. Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat Immunol. 2005 Dec; 6(12):1228-35. PMID: 16273098.
      View in: PubMed
    85. Cahalan MD, Parker I. Close encounters of the first and second kind: T-DC and T-B interactions in the lymph node. Semin Immunol. 2005 Dec; 17(6):442-51. PMID: 16263308; PMCID: PMC2953541.
    86. Demuro A, Parker I. "Optical patch-clamping": single-channel recording by imaging Ca2+ flux through individual muscle acetylcholine receptor channels. J Gen Physiol. 2005 Sep; 126(3):179-92. PMID: 16103278; PMCID: PMC2266576.
    87. Zinselmeyer BH, Dempster J, Gurney AM, Wokosin D, Miller M, Ho H, Millington OR, Smith KM, Rush CM, Parker I, Cahalan M, Brewer JM, Garside P. In situ characterization of CD4+ T cell behavior in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance. J Exp Med. 2005 Jun 06; 201(11):1815-23. PMID: 15928201.
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    88. Okada T, Miller MJ, Parker I, Krummel MF, Neighbors M, Hartley SB, O'Garra A, Cahalan MD, Cyster JG. Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol. 2005 Jun; 3(6):e150. PMID: 15857154; PMCID: PMC1088276.
    89. Shuai J, Parker I. Optical single-channel recording by imaging Ca2+ flux through individual ion channels: theoretical considerations and limits to resolution. Cell Calcium. 2005 Apr; 37(4):283-99. PMID: 15755490.
      View in: PubMed
    90. Demuro A, Mina E, Kayed R, Milton SC, Parker I, Glabe CG. Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers. J Biol Chem. 2005 Apr 29; 280(17):17294-300. PMID: 15722360.
      View in: PubMed
    91. Stutzmann GE, Parker I. Dynamic multiphoton imaging: a live view from cells to systems. Physiology (Bethesda). 2005 Feb; 20:15-21. PMID: 15653835.
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    92. Ventura AC, Bruno L, Demuro A, Parker I, Dawson SP. A model-independent algorithm to derive Ca2+ fluxes underlying local cytosolic Ca2+ transients. Biophys J. 2005 Apr; 88(4):2403-21. PMID: 15681645; PMCID: PMC1305340.
    93. Thorn P, Parker I. Two phases of zymogen granule lifetime in mouse pancreas: ghost granules linger after exocytosis of contents. J Physiol. 2005 Mar 01; 563(Pt 2):433-42. PMID: 15637100; PMCID: PMC1665585.
    94. Demuro A, Parker I. Optical single-channel recording: imaging Ca2+ flux through individual ion channels with high temporal and spatial resolution. J Biomed Opt. 2005 Jan-Feb; 10(1):11002. PMID: 15847568.
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    95. Miller MJ, Safrina O, Parker I, Cahalan MD. Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes. J Exp Med. 2004 Oct 04; 200(7):847-56. PMID: 15466619; PMCID: PMC2213293.
    96. Demuro A, Parker I. Imaging the activity and localization of single voltage-gated Ca(2+) channels by total internal reflection fluorescence microscopy. Biophys J. 2004 May; 86(5):3250-9. PMID: 15111438; PMCID: PMC1304190.
    97. Dargan SL, Schwaller B, Parker I. Spatiotemporal patterning of IP3-mediated Ca2+ signals in Xenopus oocytes by Ca2+-binding proteins. J Physiol. 2004 Apr 15; 556(Pt 2):447-61. PMID: 14755000; PMCID: PMC1664953.
    98. Stutzmann GE, Caccamo A, LaFerla FM, Parker I. Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability. J Neurosci. 2004 Jan 14; 24(2):508-13. PMID: 14724250.
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    99. Miller MJ, Hejazi AS, Wei SH, Cahalan MD, Parker I. T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node. Proc Natl Acad Sci U S A. 2004 Jan 27; 101(4):998-1003. PMID: 14722354; PMCID: PMC327133.
    100. Demuro A, Parker I. Imaging single-channel calcium microdomains by total internal reflection microscopy. Biol Res. 2004; 37(4):675-9. PMID: 15709697.
      View in: PubMed
    101. Demuro A, Parker I. Optical single-channel recording: imaging Ca2+ flux through individual N-type voltage-gated channels expressed in Xenopus oocytes. Cell Calcium. 2003 Dec; 34(6):499-509. PMID: 14572808.
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    102. Dargan SL, Parker I. Buffer kinetics shape the spatiotemporal patterns of IP3-evoked Ca2+ signals. J Physiol. 2003 Dec 15; 553(Pt 3):775-88. PMID: 14555715; PMCID: PMC2343635.
    103. Wei SH, Parker I, Miller MJ, Cahalan MD. A stochastic view of lymphocyte motility and trafficking within the lymph node. Immunol Rev. 2003 Oct; 195:136-59. PMID: 12969316.
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    106. Stutzmann GE, LaFerla FM, Parker I. Ca2+ signaling in mouse cortical neurons studied by two-photon imaging and photoreleased inositol triphosphate. J Neurosci. 2003 Feb 01; 23(3):758-65. PMID: 12574404.
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    107. Parker I. Photonics for biologists. Methods Enzymol. 2003; 360:345-82. PMID: 12622159.
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    108. Sanderson MJ, Parker I. Video-rate confocal microscopy. Methods Enzymol. 2003; 360:447-81. PMID: 12622163.
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    109. Subramanian VS, Marchant JS, Parker I, Said HM. Cell biology of the human thiamine transporter-1 (hTHTR1). Intracellular trafficking and membrane targeting mechanisms. J Biol Chem. 2003 Feb 07; 278(6):3976-84. PMID: 12454006.
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    111. Marchant JS, Subramanian VS, Parker I, Said HM. Intracellular trafficking and membrane targeting mechanisms of the human reduced folate carrier in Mammalian epithelial cells. J Biol Chem. 2002 Sep 06; 277(36):33325-33. PMID: 12087110.
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    112. Marchant JS, Ramos V, Parker I. Structural and functional relationships between Ca2+ puffs and mitochondria in Xenopus oocytes. Am J Physiol Cell Physiol. 2002 Jun; 282(6):C1374-86. PMID: 11997252.
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    113. Miller MJ, Wei SH, Parker I, Cahalan MD. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science. 2002 Jun 07; 296(5574):1869-73. PMID: 12016203.
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    114. Wei SH, Miller MJ, Cahalan MD, Parker I. Two-photon imaging in intact lymphoid tissue. Adv Exp Med Biol. 2002; 512:203-8. PMID: 12405205.
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    116. Parker I, Choi J, Yao Y. Elementary events of InsP3-induced Ca2+ liberation in Xenopus oocytes: hot spots, puffs and blips. Cell Calcium. 1996 Aug; 20(2):105-21. PMID: 8889202.
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