Hirofumi Kusumoto

Title(s)Clinical Instructor, Orthopaedic Surgery
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Physiological assessment of coronary microvascular dysfunction and short-term outcomes in severely calcified coronary lesions: a comparison between rotational atherectomy and intravascular lithotripsy. Cardiovasc Interv Ther. 2026 Jul 25. Kusumoto H, Shishikura D, Sakaguchi K, Fujioka S, Yamauchi Y, Fujisaka T, Kanzaki Y, Harada-Shiba M, Morita H. PMID: 42501239.
      View in: PubMed   Mentions:    Fields:    
    2. Myocardial infarction due to nonbacterial thrombotic endocarditis in a patient with advanced bladder cancer. Cardiovasc Interv Ther. 2026 Jul; 41(3):833-834. Kusumoto H, Inoue M, Shishikura D, Kanzaki Y, Harada-Shiba M, Morita H. PMID: 41917561.
      View in: PubMed   Mentions:    Fields:    
    3. Comparison of Clinical Characterization and Therapeutic Strategies between Homozygous Familial Hypercholesterolemia and Heterozygous Familial Hypercholesterolemia. J Atheroscler Thromb. 2026 Jul 01; 33(7):884-894. Shishikura D, Harada-Shiba M, Michikura M, Sakaguchi K, Kusumoto H, Fujioka S, Fujisaka T, Kanzaki Y, Morita H. PMID: 41905938; PMCID: PMC13345719.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Impact of High-Intensity Statins and Low-Density Lipoprotein Cholesterol on the Outcomes of Coronary Intervention for Chronic Coronary Syndrome in Japan. J Atheroscler Thromb. 2026 Jul 01; 33(7):922-936. Yamauchi Y, Kanzaki Y, Shishikura D, Sakaguchi K, Fujioka S, Kusumoto H, Tsuda K, Sakane K, Fujisaka T, Michikura M, Harada-Shiba M, Morita H. PMID: 41905939; PMCID: PMC13345711.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Transpedal intervention for common femoral artery stenosis caused by a suture-mediated vascular closure device after transcatheter aortic valve replacement. Cardiovasc Interv Ther. 2026 Jul; 41(3):839-840. Kusumoto H, Takiuchi S, Ishibuchi K, Otsuji S. PMID: 41845173.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Safety and clinical outcomes of micro-axial intravascular flow pump compared to intra-aortic balloon pump in cardiogenic shock. Cardiovasc Diagn Ther. 2026 Feb 28; 16(1):2. Makino M, Shishikura D, Kusumoto H, Yamauchi Y, Sakane K, Fujisaka T, Zushi R, Kanzaki Y, Hoshiga M, Morita H. PMID: 41815572; PMCID: PMC12973085.
      View in: PubMed   Mentions:
    7. Association of Achilles Tendon Thickness with Severity of Coronary Artery Disease in Non -Familial Hypercholesterolemia. J Atheroscler Thromb. 2026 May 01; 33(5):578-588. Fujioka S, Shishikura D, Sakaguchi K, Kusumoto H, Michikura M, Kanzaki Y, Harada-Shiba M, Morita H. PMID: 41443833; PMCID: PMC13158046.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Discordance in Achilles Tendon Assessment between Radiography and Ultrasonography due to Torsion. J Atheroscler Thromb. 2026 Apr 01; 33(4):417-427. Sakaguchi K, Fujioka S, Shishikura D, Michikura M, Kusumoto H, Kanzaki Y, Harada-Shiba M, Morita H. PMID: 41139505; PMCID: PMC13053201.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Immediate supraphysiologic load bearing of the spine appears safe after gunshot-related spinal cord injury: a case-control study. Spinal Cord. 2025 12; 63(12):660-663. Kusumoto H, Alvarez IM, Fukunaga D, Dreyer SD, Rolfe KW. PMID: 41094116.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Flexibility radiographs in pediatric spine surgery are often used but lack consistency. Eur Spine J. 2025 Jul; 34(7):2695-2700. Kusumoto H, Tetreault TA, Heffernan MJ, Sponseller PD, Cheung KMC, Gomez JA, Hwang SW, Gupta P, Pediatric Spine Study Group, Andras LM. PMID: 40108038.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Characterization of lipidic plaque features in association with LDL-C<70 mg/dL and lipoprotein(a) <50 mg/dL. J Clin Lipidol. 2025 May-Jun; 19(3):509-520. Shishikura D, Kataoka Y, Nicholls SJ, Ray KK, Puri R, Kusumoto H, Yamauchi Y, Sakane K, Fujisaka T, Morita H, Murai K, Iwai T, Sawada K, Matama H, Honda S, Fujino M, Yoneda S, Takagi K, Nakao K, Otsuka F, Nishihira K, Takamisawa I, Asaumi Y, Noguchi T, Harada-Shiba M, Hoshiga M. PMID: 39955203.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    12. Clinical impact of ≥50% reduction of low density lipoprotein cholesterol following lipid lowering therapy on cardiovascular outcomes in patients with acute coronary syndrome. J Clin Lipidol. 2025 Mar-Apr; 19(2):247-255. Fujioka S, Shishikura D, Kusumoto H, Yamauchi Y, Sakane K, Fujisaka T, Shibata K, Morita H, Kanzaki Y, Michikura M, Harada-Shiba M, Hoshiga M. PMID: 40024838.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor. Cell Mol Life Sci. 2024 Mar 28; 81(1):153. Xu Y, Song R, Perszyk RE, Chen W, Kim S, Park KL, Allen JP, Nocilla KA, Zhang J, XiangWei W, Tankovic A, McDaniels ED, Sheikh R, Mizu RK, Karamchandani MM, Hu C, Kusumoto H, Pecha J, Cappuccio G, Gaitanis J, Sullivan J, Shashi V, Petrovski S, Jauss RT, Lee HK, Bozarth X, Lynch DR, Helbig I, Pierson TM, Boerkoel CF, Myers SJ, Lemke JR, Benke TA, Yuan H, Traynelis SF. PMID: 38538865; PMCID: PMC10973091.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    14. Usefulness of transpedal intervention for inferior epigastric artery bleeding following catheter ablation: a case report. Eur Heart J Case Rep. 2022 May; 6(5):ytac181. Kusumoto H, Ishibuchi K, Takiuchi S, Otsuji S. PMID: 35542825; PMCID: PMC9081598.
      View in: PubMed   Mentions:
    15. Trans-coronary pacing via Rota wire prevents bradycardia during rotational atherectomy: a case report. Eur Heart J Case Rep. 2022 Feb; 6(2):ytac013. Kusumoto H, Ishibuchi K, Hasegawa K, Otsuji S. PMID: 35295733; PMCID: PMC8922706.
      View in: PubMed   Mentions: 6  
    16. Factors Contributing to Diurnal Variation in Athletic Performance and Methods to Reduce Within-Day Performance Variation: A Systematic Review. J Strength Cond Res. 2021 Dec 01; 35(Suppl 12):S119-S135. Kusumoto H, Ta C, Brown SM, Mulcahey MK. PMID: 32868676.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    17. Short term outcomes of an enhanced recovery after surgery (ERAS) pathway versus a traditional discharge pathway after posterior spinal fusion for adolescent idiopathic scoliosis. Spine Deform. 2021 07; 9(4):1013-1019. Fletcher ND, Murphy JS, Austin TM, Bruce RW, Harris H, Bush P, Yu A, Kusumoto H, Schmitz ML, Devito DP, Fabregas JA, Miyanji F. PMID: 33460022.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    18. A novel treatment using a guide extension catheter and distal protection device for refractory coronary embolism: case report. Eur Heart J Case Rep. 2021 Jan; 5(1):ytaa507. Kusumoto H, Hasegawa K, Ishibuchi K, Otsuji S. PMID: 34263112; PMCID: PMC8274647.
      View in: PubMed   Mentions: 1  
    19. Late peri-stent contrast staining appearance due to rupture of atherogenic neointima following drug-eluting stent. J Cardiol Cases. 2021 May; 23(5):210-213. Tamaru H, Fujii K, Otsuji S, Takiuchi S, Hasegawa K, Ishibuchi K, Ishii R, Yamamoto W, Nakabayashi S, Yasuda S, Kusumoto H, Taniguchi Y, Kakishita M, Shimatani Y, Higashino Y. PMID: 33995698; PMCID: PMC8103349.
      View in: PubMed   Mentions:
    20. Acute myocardial infarction in a patient with uncorrected tetralogy of Fallot accompanied by coronary artery ectasia: A case report. J Cardiol Cases. 2021 Mar; 23(3):119-122. Yamamoto W, Otsuji S, Takiuchi S, Kakishita M, Shimatani Y, Hasegawa K, Ishibuchi K, Tamaru H, Ishii R, Yasuda S, Taniguchi Y, Nakabayashi S, Kusumoto H, Higashino Y. PMID: 33717376; PMCID: PMC7917400.
      View in: PubMed   Mentions: 1  
    21. Successful percutaneous removal of dislodged ring-marker of optical coherence tomography catheter using the twisted wire technique with a guide-extension catheter: A case report. J Cardiol Cases. 2020 Nov; 22(5):242-245. Yamamoto W, Otsuji S, Takiuchi S, Kakishita M, Shimatani Y, Hasegawa K, Ishibuchi K, Tamaru H, Ishii R, Yasuda S, Taniguchi Y, Nakabayashi S, Kusumoto H, Higashino Y. PMID: 33133319; PMCID: PMC7588481.
      View in: PubMed   Mentions:
    22. Management of Orthopaedic Emergencies During a Pandemic: Compartment Syndrome of the Hand in a Patient with COVID-19: A Case Report. JBJS Case Connect. 2020 Jul-Sep; 10(3):e20.00377. Hill KL, Wu VJ, Kusumoto H, Sherman WF, Savoie FH. PMID: 32960013.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCellsPHPublic Health
    23. Effect of neointimal tissue morphology on vascular response to balloon angioplasty in lesions with in-stent restenosis after drug-eluting stent deployment: an optical coherence tomography analysis. Heart Vessels. 2020 Sep; 35(9):1193-1200. Yamamoto W, Fujii K, Otsuji S, Takiuchi S, Kakishita M, Shimatani Y, Hasegawa K, Ishibuchi K, Tamaru H, Ishii R, Yasuda S, Taniguchi Y, Nakabayashi S, Kusumoto H, Higashino Y. PMID: 32253529.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    24. Heterogeneous clinical and functional features of GRIN2D-related developmental and epileptic encephalopathy. Brain. 2019 10 01; 142(10):3009-3027. XiangWei W, Kannan V, Xu Y, Kosobucki GJ, Schulien AJ, Kusumoto H, Moufawad El Achkar C, Bhattacharya S, Lesca G, Nguyen S, Helbig KL, Cuisset JM, Fenger CD, Marjanovic D, Schuler E, Wu Y, Bao X, Zhang Y, Dirkx N, Schoonjans AS, Syrbe S, Myers SJ, Poduri A, Aizenman E, Traynelis SF, Lemke JR, Yuan H, Jiang Y. PMID: 31504254; PMCID: PMC6763743.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    25. De novo GRIN variants in NMDA receptor M2 channel pore-forming loop are associated with neurological diseases. Hum Mutat. 2019 12; 40(12):2393-2413. Li J, Zhang J, Tang W, Mizu RK, Kusumoto H, XiangWei W, Xu Y, Chen W, Amin JB, Hu C, Kannan V, Keller SR, Wilcox WR, Lemke JR, Myers SJ, Swanger SA, Wollmuth LP, Petrovski S, Traynelis SF, Yuan H. PMID: 31429998; PMCID: PMC6874887.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    26. Utility and Validity of Intracoronary Administration of Nicorandil Alone for the Measurement of Fractional Flow Reserve in Patients With Intermediate Coronary Stenosis. Circ J. 2019 09 25; 83(10):2010-2016. Ishibuchi K, Fujii K, Otsuji S, Takiuchi S, Hasegawa K, Tamaru H, Ishii R, Yasuda S, Nakabayashi S, Yamamoto W, Kusumoto H, Taniguchi Y, Kakishita M, Shimatani Y, Higashino Y. PMID: 31413232.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    27. Optical coherence tomography characteristics of in-stent restenosis after drug-eluting stent implantation: a novel classification and its clinical significance. Heart Vessels. 2020 Jan; 35(1):38-45. Yamamoto W, Fujii K, Otsuji S, Takiuchi S, Kakishita M, Ibuki M, Hasegawa K, Ishibuchi K, Tamaru H, Yasuda S, Ishii R, Nakabayashi S, Kusumoto H, Higashino Y. PMID: 31250131.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    28. The GluN2B-Glu413Gly NMDA receptor variant arising from a de novo GRIN2B mutation promotes ligand-unbinding and domain opening. Proteins. 2018 12; 86(12):1265-1276. Wells G, Yuan H, McDaniel MJ, Kusumoto H, Snyder JP, Liotta DC, Traynelis SF. PMID: 30168177; PMCID: PMC6774441.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    29. An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups. Elife. 2018 05 24; 7. Perszyk R, Katzman BM, Kusumoto H, Kell SA, Epplin MP, Tahirovic YA, Moore RL, Menaldino D, Burger P, Liotta DC, Traynelis SF. PMID: 29792594; PMCID: PMC5967867.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    30. A novel missense mutation in GRIN2A causes a nonepileptic neurodevelopmental disorder. Mov Disord. 2018 Jul; 33(6):992-999. Fernández-Marmiesse A, Kusumoto H, Rekarte S, Roca I, Zhang J, Myers SJ, Traynelis SF, Couce ML, Gutierrez-Solana L, Yuan H. PMID: 29644724; PMCID: PMC6105539.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    31. De novo mutations in GRIN1 cause extensive bilateral polymicrogyria. Brain. 2018 03 01; 141(3):698-712. Fry AE, Fawcett KA, Zelnik N, Yuan H, Thompson BAN, Shemer-Meiri L, Cushion TD, Mugalaasi H, Sims D, Stoodley N, Chung SK, Rees MI, Patel CV, Brueton LA, Layet V, Giuliano F, Kerr MP, Banne E, Meiner V, Lerman-Sagie T, Helbig KL, Kofman LH, Knight KM, Chen W, Kannan V, Hu C, Kusumoto H, Zhang J, Swanger SA, Shaulsky GH, Mirzaa GM, Muir AM, Mefford HC, Dobyns WB, Mackenzie AB, Mullins JGL, Lemke JR, Bahi-Buisson N, Traynelis SF, Iago HF, Pilz DT. PMID: 29365063; PMCID: PMC5837214.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    32. The Bioactive Protein-Ligand Conformation of GluN2C-Selective Positive Allosteric Modulators Bound to the NMDA Receptor. Mol Pharmacol. 2018 02; 93(2):141-156. Kaiser TM, Kell SA, Kusumoto H, Shaulsky G, Bhattacharya S, Epplin MP, Strong KL, Miller EJ, Cox BD, Menaldino DS, Liotta DC, Traynelis SF, Burger PB. PMID: 29242355; PMCID: PMC5767683.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    33. GRIN2B encephalopathy: novel findings on phenotype, variant clustering, functional consequences and treatment aspects. J Med Genet. 2017 07; 54(7):460-470. Platzer K, Yuan H, Schütz H, Winschel A, Chen W, Hu C, Kusumoto H, Heyne HO, Helbig KL, Tang S, Willing MC, Tinkle BT, Adams DJ, Depienne C, Keren B, Mignot C, Frengen E, Strømme P, Biskup S, Döcker D, Strom TM, Mefford HC, Myers CT, Muir AM, LaCroix A, Sadleir L, Scheffer IE, Brilstra E, van Haelst MM, van der Smagt JJ, Bok LA, Møller RS, Jensen UB, Millichap JJ, Berg AT, Goldberg EM, De Bie I, Fox S, Major P, Jones JR, Zackai EH, Abou Jamra R, Rolfs A, Leventer RJ, Lawson JA, Roscioli T, Jansen FE, Ranza E, Korff CM, Lehesjoki AE, Courage C, Linnankivi T, Smith DR, Stanley C, Mintz M, McKnight D, Decker A, Tan WH, Tarnopolsky MA, Brady LI, Wolff M, Dondit L, Pedro HF, Parisotto SE, Jones KL, Patel AD, Franz DN, Vanzo R, Marco E, Ranells JD, Di Donato N, Dobyns WB, Laube B, Traynelis SF, Lemke JR. PMID: 28377535; PMCID: PMC5656050.
      View in: PubMed   Mentions: 134     Fields:    Translation:Humans
    34. A de novo loss-of-function GRIN2A mutation associated with childhood focal epilepsy and acquired epileptic aphasia. PLoS One. 2017; 12(2):e0170818. Gao K, Tankovic A, Zhang Y, Kusumoto H, Zhang J, Chen W, XiangWei W, Shaulsky GH, Hu C, Traynelis SF, Yuan H, Jiang Y. PMID: 28182669; PMCID: PMC5300259.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    35. Functional Evaluation of a De Novo GRIN2A Mutation Identified in a Patient with Profound Global Developmental Delay and Refractory Epilepsy. Mol Pharmacol. 2017 04; 91(4):317-330. Chen W, Tankovic A, Burger PB, Kusumoto H, Traynelis SF, Yuan H. PMID: 28126851; PMCID: PMC5363715.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    36. Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology. PLoS Genet. 2017 Jan; 13(1):e1006536. Ogden KK, Chen W, Swanger SA, McDaniel MJ, Fan LZ, Hu C, Tankovic A, Kusumoto H, Kosobucki GJ, Schulien AJ, Su Z, Pecha J, Bhattacharya S, Petrovski S, Cohen AE, Aizenman E, Traynelis SF, Yuan H. PMID: 28095420; PMCID: PMC5240934.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    37. Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains. Am J Hum Genet. 2016 Dec 01; 99(6):1261-1280. Swanger SA, Chen W, Wells G, Burger PB, Tankovic A, Bhattacharya S, Strong KL, Hu C, Kusumoto H, Zhang J, Adams DR, Millichap JJ, Petrovski S, Traynelis SF, Yuan H. PMID: 27839871; PMCID: PMC5142120.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansCells
    38. GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers. Am J Hum Genet. 2016 Oct 06; 99(4):802-816. Li D, Yuan H, Ortiz-Gonzalez XR, Marsh ED, Tian L, McCormick EM, Kosobucki GJ, Chen W, Schulien AJ, Chiavacci R, Tankovic A, Naase C, Brueckner F, von Stülpnagel-Steinbeis C, Hu C, Kusumoto H, Hedrich UB, Elsen G, Hörtnagel K, Aizenman E, Lemke JR, Hakonarson H, Traynelis SF, Falk MJ. PMID: 27616483; PMCID: PMC5065652.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
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