Harry T Haigler

Title(s)Professor Emeritus, Physiology and Biophysics
Address1001 Health Sciences Road
Irvine CA 92697-3950
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    Structure and Function of Annexins on Membranes
    NIH R01GM055651Jun 1, 1997 - Feb 28, 2010
    Role: Principal Investigator
    EGF-STIMULATED PROTEIN-TYR KINASES AND THEIR SUBSTRATES
    NIH R01GM037844Jan 1, 1987 - Dec 31, 1989
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Annexin B12 is a sensor of membrane curvature and undergoes major curvature-dependent structural changes. J Biol Chem. 2007 Mar 30; 282(13):9996-10004. Fischer T, Lu L, Haigler HT, Langen R. PMID: 17267400.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    2. A novel calcium-independent peripheral membrane-bound form of annexin B12. Biochemistry. 2006 Jan 24; 45(3):934-42. Hegde BG, Isas JM, Zampighi G, Haigler HT, Langen R. PMID: 16411769.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    3. Calcium- and membrane-induced changes in the structure and dynamics of three helical hairpins in annexin B12. Biochemistry. 2005 Dec 20; 44(50):16435-44. Isas JM, Kim YE, Jao CC, Hegde PB, Haigler HT, Langen R. PMID: 16342936.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    4. A helical hairpin region of soluble annexin B12 refolds and forms a continuous transmembrane helix at mildly acidic pH. J Biol Chem. 2005 Sep 16; 280(37):32398-404. Kim YE, Isas JM, Haigler HT, Langen R. PMID: 15975928.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    5. Reversible transition between the surface trimer and membrane-inserted monomer of annexin 12. Biochemistry. 2005 Mar 08; 44(9):3402-9. Ladokhin AS, Haigler HT. PMID: 15736950.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    6. The conserved core domains of annexins A1, A2, A5, and B12 can be divided into two groups with different Ca2+-dependent membrane-binding properties. Biochemistry. 2005 Mar 01; 44(8):2833-44. Patel DR, Isas JM, Ladokhin AS, Jao CC, Kim YE, Kirsch T, Langen R, Haigler HT. PMID: 15723527.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    7. Structure and dynamics of a helical hairpin that mediates calcium-dependent membrane binding of annexin B12. J Biol Chem. 2004 Jul 30; 279(31):32492-8. Isas JM, Langen R, Hubbell WL, Haigler HT. PMID: 15143059.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    8. Structure and dynamics of annexin 12 bound to a planar lipid bilayer. Phys Rev Lett. 2003 Oct 31; 91(18):188101. Risse T, Hubbell WL, Isas JM, Haigler HT. PMID: 14611318.
      View in: PubMed   Mentions: 5     Fields:    
    9. Global structural changes in annexin 12. The roles of phospholipid, Ca2+, and pH. J Biol Chem. 2003 Aug 08; 278(32):30227-34. Isas JM, Patel DR, Jao C, Jayasinghe S, Cartailler JP, Haigler HT, Langen R. PMID: 12756261.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    10. Determining the membrane topology of proteins: insertion pathway of a transmembrane helix of annexin 12. Biochemistry. 2002 Nov 19; 41(46):13617-26. Ladokhin AS, Isas JM, Haigler HT, White SH. PMID: 12427023.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    11. Structure and dynamics of a helical hairpin and loop region in annexin 12: a site-directed spin labeling study. Biochemistry. 2002 Feb 05; 41(5):1464-73. Isas JM, Langen R, Haigler HT, Hubbell WL. PMID: 11814339.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    12. Calcium-dependent binding of annexin 12 to phospholipid bilayers: stoichiometry and implications. Biochemistry. 2001 Jun 19; 40(24):7054-60. Patel DR, Jao CC, Mailliard WS, Isas JM, Langen R, Haigler HT. PMID: 11401549.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    13. Annexins V and XII alter the properties of planar lipid bilayers seen by conductance probes. J Gen Physiol. 2000 May; 115(5):571-82. Sokolov Y, Mailliard WS, Tranngo N, Isas M, Luecke H, Haigler HT, Hall JE. PMID: 10779315.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    14. Annexins V and XII insert into bilayers at mildly acidic pH and form ion channels. Biochemistry. 2000 Mar 21; 39(11):3015-22. Isas JM, Cartailler JP, Sokolov Y, Patel DR, Langen R, Luecke H, Hall JE, Haigler HT. PMID: 10715122.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    15. Annexin XII E105K crystal structure: identification of a pH-dependent switch for mutant hexamerization. Biochemistry. 2000 Mar 14; 39(10):2475-83. Cartailler JP, Haigler HT, Luecke H. PMID: 10704197.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    16. Annexin 5 mediates a peroxide-induced Ca(2+) influx in B cells. Curr Biol. 1999 Dec 02; 9(23):1403-6. Kubista H, Hawkins TE, Patel DR, Haigler HT, Moss SE. PMID: 10607568.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    17. A transmembrane form of annexin XII detected by site-directed spin labeling. Proc Natl Acad Sci U S A. 1998 Nov 24; 95(24):14060-5. Langen R, Isas JM, Hubbell WL, Haigler HT. PMID: 9826653.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    18. CCG1/TAF(II)250 regulates epidermal growth factor receptor gene transcription in cell cycle mutant ts13. J Cell Physiol. 1998 Sep; 176(3):642-7. Vargas GA, Isas JM, Fantino E, Gargus JJ, Haigler HT. PMID: 9699517.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    19. Membrane-mediated assembly of annexins studied by site-directed spin labeling. J Biol Chem. 1998 Aug 28; 273(35):22453-7. Langen R, Isas JM, Luecke H, Haigler HT, Hubbell WL. PMID: 9712869.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    20. Annexin XII forms calcium-dependent multimers in solution and on phospholipid bilayers: a chemical cross-linking study. Biochemistry. 1997 Jul 22; 36(29):9045-50. Mailliard WS, Luecke H, Haigler HT. PMID: 9220993.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    21. Calcium-dependent binding of S100C to the N-terminal domain of annexin I. J Biol Chem. 1996 Jan 12; 271(2):719-25. Mailliard WS, Haigler HT, Schlaepfer DD. PMID: 8557678.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    22. Crystal structure of the annexin XII hexamer and implications for bilayer insertion. Nature. 1995 Nov 30; 378(6556):512-5. Luecke H, Chang BT, Mailliard WS, Schlaepfer DD, Haigler HT. PMID: 7477411.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    23. Identification and characterization of columbid annexin Icp37. Insights into the evolution of annexin I phosphorylation sites. J Biol Chem. 1992 Sep 25; 267(27):19123-9. Haigler HT, Mangili JA, Gao Y, Jones J, Horseman ND. PMID: 1388165.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    24. Inhibition of protein kinase C by annexin V. Biochemistry. 1992 Feb 18; 31(6):1886-91. Schlaepfer DD, Jones J, Haigler HT. PMID: 1310621.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    25. Calcium-activated endonexin II forms calcium channels across acidic phospholipid bilayer membranes. J Biol Chem. 1990 Dec 05; 265(34):21207-15. Rojas E, Pollard HB, Haigler HT, Parra C, Burns AL. PMID: 2174439.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    26. Expression of lipocortin 1 and endonexin II as a function of cellular growth state. Prog Clin Biol Res. 1990; 349:91-8. Haigler HT, Schlaepfer DD. PMID: 2144648.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    27. In vitro protein kinase C phosphorylation sites of placental lipocortin. Biochemistry. 1988 Jun 14; 27(12):4253-8. Schlaepfer DD, Haigler HT. PMID: 2971390.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    28. Characterization of Ca2+-dependent phospholipid binding and phosphorylation of lipocortin I. J Biol Chem. 1987 May 15; 262(14):6931-7. Schlaepfer DD, Haigler HT. PMID: 2952659.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    29. Epidermal growth factor dependent phosphorylation of a 35-kilodalton protein in placental membranes. Biochemistry. 1987 Feb 24; 26(4):1164-72. Sheets EE, Giugni TD, Coates GG, Schlaepfer DD, Haigler HT. PMID: 3105577.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
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