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Harry T Haigler

Title(s)Professor Emeritus, Physiology and Biophysics
Address1001 Health Sciences Road
Irvine CA 92697-3950
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    Structure and Function of Annexins on Membranes
    NIH R01GM055651Jun 1, 1997 - Dec 31, 2005
    Role: Principal Investigator
    EGF-STIMULATED PROTEIN-TYR KINASES AND THEIR SUBSTRATES
    NIH R01GM037844Jan 1, 1987 - Dec 31, 1989
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Annexin B12 is a sensor of membrane curvature and undergoes major curvature-dependent structural changes. J Biol Chem. 2007 Mar 30; 282(13):9996-10004. Fischer T, Lu L, Haigler HT, Langen R. PMID: 17267400.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    2. A novel calcium-independent peripheral membrane-bound form of annexin B12. Biochemistry. 2006 Jan 24; 45(3):934-42. Hegde BG, Isas JM, Zampighi G, Haigler HT, Langen R. PMID: 16411769.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    3. Calcium- and membrane-induced changes in the structure and dynamics of three helical hairpins in annexin B12. Biochemistry. 2005 Dec 20; 44(50):16435-44. Isas JM, Kim YE, Jao CC, Hegde PB, Haigler HT, Langen R. PMID: 16342936.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    4. A helical hairpin region of soluble annexin B12 refolds and forms a continuous transmembrane helix at mildly acidic pH. J Biol Chem. 2005 Sep 16; 280(37):32398-404. Kim YE, Isas JM, Haigler HT, Langen R. PMID: 15975928.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    5. Reversible transition between the surface trimer and membrane-inserted monomer of annexin 12. Biochemistry. 2005 Mar 08; 44(9):3402-9. Ladokhin AS, Haigler HT. PMID: 15736950.
      View in: PubMed   Mentions:
    6. The conserved core domains of annexins A1, A2, A5, and B12 can be divided into two groups with different Ca2+-dependent membrane-binding properties. Biochemistry. 2005 Mar 01; 44(8):2833-44. Patel DR, Isas JM, Ladokhin AS, Jao CC, Kim YE, Kirsch T, Langen R, Haigler HT. PMID: 15723527.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    7. Structure and dynamics of a helical hairpin that mediates calcium-dependent membrane binding of annexin B12. J Biol Chem. 2004 Jul 30; 279(31):32492-8. Isas JM, Langen R, Hubbell WL, Haigler HT. PMID: 15143059.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    8. Diffusion of single cardiac ryanodine receptors in lipid bilayers is decreased by annexin 12. Biophys J. 2004 Jan; 86(1 Pt 1):145-51. Peng S, Publicover NG, Airey JA, Hall JE, Haigler HT, Jiang D, Chen SR, Sutko JL. PMID: 14695258.
      View in: PubMed   Mentions:
    9. Structure and dynamics of annexin 12 bound to a planar lipid bilayer. Phys Rev Lett. 2003 Oct 31; 91(18):188101. Risse T, Hubbell WL, Isas JM, Haigler HT. PMID: 14611318.
      View in: PubMed   Mentions: 5     Fields:    
    10. Global structural changes in annexin 12. The roles of phospholipid, Ca2+, and pH. J Biol Chem. 2003 Aug 08; 278(32):30227-34. Isas JM, Patel DR, Jao C, Jayasinghe S, Cartailler JP, Haigler HT, Langen R. PMID: 12756261.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    11. Determining the membrane topology of proteins: insertion pathway of a transmembrane helix of annexin 12. Biochemistry. 2002 Nov 19; 41(46):13617-26. Ladokhin AS, Isas JM, Haigler HT, White SH. PMID: 12427023.
      View in: PubMed   Mentions:
    12. Structure and dynamics of a helical hairpin and loop region in annexin 12: a site-directed spin labeling study. Biochemistry. 2002 Feb 05; 41(5):1464-73. Isas JM, Langen R, Haigler HT, Hubbell WL. PMID: 11814339.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    13. Calcium-dependent binding of annexin 12 to phospholipid bilayers: stoichiometry and implications. Biochemistry. 2001 Jun 19; 40(24):7054-60. Patel DR, Jao CC, Mailliard WS, Isas JM, Langen R, Haigler HT. PMID: 11401549.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    14. Annexins V and XII alter the properties of planar lipid bilayers seen by conductance probes. J Gen Physiol. 2000 May; 115(5):571-82. Sokolov Y, Mailliard WS, Tranngo N, Isas M, Luecke H, Haigler HT, Hall JE. PMID: 10779315.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    15. Annexins V and XII insert into bilayers at mildly acidic pH and form ion channels. Biochemistry. 2000 Mar 21; 39(11):3015-22. Isas JM, Cartailler JP, Sokolov Y, Patel DR, Langen R, Luecke H, Hall JE, Haigler HT. PMID: 10715122.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    16. Annexin XII E105K crystal structure: identification of a pH-dependent switch for mutant hexamerization. Biochemistry. 2000 Mar 14; 39(10):2475-83. Cartailler JP, Haigler HT, Luecke H. PMID: 10704197.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    17. Annexin 5 mediates a peroxide-induced Ca(2+) influx in B cells. Curr Biol. 1999 Dec 02; 9(23):1403-6. Kubista H, Hawkins TE, Patel DR, Haigler HT, Moss SE. PMID: 10607568.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    18. A transmembrane form of annexin XII detected by site-directed spin labeling. Proc Natl Acad Sci U S A. 1998 Nov 24; 95(24):14060-5. Langen R, Isas JM, Hubbell WL, Haigler HT. PMID: 9826653.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    19. CCG1/TAF(II)250 regulates epidermal growth factor receptor gene transcription in cell cycle mutant ts13. J Cell Physiol. 1998 Sep; 176(3):642-7. Vargas GA, Isas JM, Fantino E, Gargus JJ, Haigler HT. PMID: 9699517.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    20. Membrane-mediated assembly of annexins studied by site-directed spin labeling. J Biol Chem. 1998 Aug 28; 273(35):22453-7. Langen R, Isas JM, Luecke H, Haigler HT, Hubbell WL. PMID: 9712869.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    21. Annexin XII forms calcium-dependent multimers in solution and on phospholipid bilayers: a chemical cross-linking study. Biochemistry. 1997 Jul 22; 36(29):9045-50. Mailliard WS, Luecke H, Haigler HT. PMID: 9220993.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    22. Reduced epidermal growth factor receptor expression in hypohidrotic ectodermal dysplasia and Tabby mice. J Clin Invest. 1996 Jun 01; 97(11):2426-32. Vargas GA, Fantino E, George-Nascimento C, Gargus JJ, Haigler HT. PMID: 8647934.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    23. Calcium-dependent binding of S100C to the N-terminal domain of annexin I. J Biol Chem. 1996 Jan 12; 271(2):719-25. Mailliard WS, Haigler HT, Schlaepfer DD. PMID: 8557678.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    24. Crystal structure of the annexin XII hexamer and implications for bilayer insertion. Nature. 1995 Nov 30; 378(6556):512-5. Luecke H, Chang BT, Mailliard WS, Schlaepfer DD, Haigler HT. PMID: 7477411.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    25. Identification and characterization of columbid annexin Icp37. Insights into the evolution of annexin I phosphorylation sites. J Biol Chem. 1992 Sep 25; 267(27):19123-9. Haigler HT, Mangili JA, Gao Y, Jones J, Horseman ND. PMID: 1388165.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    26. Distinct cellular expression pattern of annexins in Hydra vulgaris. J Cell Biol. 1992 Aug; 118(4):911-28. Schlaepfer DD, Bode HR, Haigler HT. PMID: 1500430.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    27. Identification of a novel annexin in Hydra vulgaris. Characterization, cDNA cloning, and protein kinase C phosphorylation of annexin XII. J Biol Chem. 1992 May 15; 267(14):9529-39. Schlaepfer DD, Fisher DA, Brandt ME, Bode HR, Jones JM, Haigler HT. PMID: 1339458.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    28. Identification of annexins as calcium channels in biological membranes. Bone Miner. 1992 May; 17(2):214-8. Rojas E, Arispe N, Haigler HT, Burns AL, Pollard HB. PMID: 1319252.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    29. Inhibition of protein kinase C by annexin V. Biochemistry. 1992 Feb 18; 31(6):1886-91. Schlaepfer DD, Jones J, Haigler HT. PMID: 1310621.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    30. Selective secretion of annexin 1, a protein without a signal sequence, by the human prostate gland. J Biol Chem. 1991 Feb 05; 266(4):2499-507. Christmas P, Callaway J, Fallon J, Jones J, Haigler HT. PMID: 1824943.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    31. Calcium-activated endonexin II forms calcium channels across acidic phospholipid bilayer membranes. J Biol Chem. 1990 Dec 05; 265(34):21207-15. Rojas E, Pollard HB, Haigler HT, Parra C, Burns AL. PMID: 2174439.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    32. Annexin 1 is secreted by the human prostate. Biochem Soc Trans. 1990 Dec; 18(6):1104-6. Haigler HT, Christmas P. PMID: 2150940.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    33. Expression of annexins as a function of cellular growth state. J Cell Biol. 1990 Jul; 111(1):229-38. Schlaepfer DD, Haigler HT. PMID: 2142163.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    34. Expression of lipocortin 1 and endonexin II as a function of cellular growth state. Prog Clin Biol Res. 1990; 349:91-8. Haigler HT, Schlaepfer DD. PMID: 2144648.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    35. Lack of phosphorylation of lipocortin I in A431 epidermoid carcinoma cells treated with phorbol esters. Biochem Biophys Res Commun. 1989 Apr 28; 160(2):474-9. William F, Haigler HT, Kraft AS. PMID: 2524194.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    36. Two lipocortin-like proteins, endonexin II and anchorin CII, may be alternate splices of the same gene. Trends Biochem Sci. 1989 Feb; 14(2):48-50. Haigler HT, Fitch JM, Jones JM, Schlaepfer DD. PMID: 2539661.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    37. Purification and biochemical assay of synexin and of the homologous calcium-dependent membrane-binding proteins, endonexin II and lipocortin I. Methods Cell Biol. 1989; 31:207-27. Pollard HB, Burns AL, Rojas E, Schlaepfer DD, Haigler H, Brocklehurst K. PMID: 2528669.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    38. Cloning and expression of cDNA for human endonexin II, a Ca2+ and phospholipid binding protein. J Biol Chem. 1988 Jun 15; 263(17):8037-43. Kaplan R, Jaye M, Burgess WH, Schlaepfer DD, Haigler HT. PMID: 2967291.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    39. In vitro protein kinase C phosphorylation sites of placental lipocortin. Biochemistry. 1988 Jun 14; 27(12):4253-8. Schlaepfer DD, Haigler HT. PMID: 2971390.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    40. Structural and functional characterization of endonexin II, a calcium- and phospholipid-binding protein. Proc Natl Acad Sci U S A. 1987 Sep; 84(17):6078-82. Schlaepfer DD, Mehlman T, Burgess WH, Haigler HT. PMID: 2957692.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    41. Characterization of Ca2+-dependent phospholipid binding and phosphorylation of lipocortin I. J Biol Chem. 1987 May 15; 262(14):6931-7. Schlaepfer DD, Haigler HT. PMID: 2952659.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    42. Characterization of lipocortin I and an immunologically unrelated 33-kDa protein as epidermal growth factor receptor/kinase substrates and phospholipase A2 inhibitors. J Biol Chem. 1987 May 15; 262(14):6921-30. Haigler HT, Schlaepfer DD, Burgess WH. PMID: 3032981.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    43. Electric field-induced redistribution and postfield relaxation of epidermal growth factor receptors on A431 cells. J Cell Biol. 1987 May; 104(5):1291-7. Giugni TD, Braslau DL, Haigler HT. PMID: 3494733.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    44. Epidermal growth factor dependent phosphorylation of a 35-kilodalton protein in placental membranes. Biochemistry. 1987 Feb 24; 26(4):1164-72. Sheets EE, Giugni TD, Coates GG, Schlaepfer DD, Haigler HT. PMID: 3105577.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    45. Epidermal growth factor stimulates tyrosine phosphorylation of specific proteins in permeabilized human fibroblasts. J Biol Chem. 1985 Dec 05; 260(28):15081-90. Giugni TD, James LC, Haigler HT. PMID: 3877722.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    46. Altered degradation of epidermal growth factor in a diphtheria toxin-resistant clone of KB cells. J Cell Physiol. 1985 Aug; 124(2):322-30. Haigler HT, Wiley HS, Moehring JM, Moehring TJ. PMID: 3876344.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    47. Radiation inactivation of ricin occurs with transfer of destructive energy across a disulfide bridge. Proc Natl Acad Sci U S A. 1985 Aug; 82(16):5357-9. Haigler HT, Woodbury DJ, Kempner ES. PMID: 3860867.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    48. Molecular size of the epidermal growth factor receptor-kinase as determined by radiation inactivation. J Biol Chem. 1985 Feb 25; 260(4):2178-84. Haigler HT, End D, Kempner E. PMID: 2982812.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    49. The morphologic pathway of binding and internalization of epidermal growth factor in cultured cells. Studies on A431, KB, and 3T3 cells, using multiple methods of labelling. Exp Cell Res. 1983 Jun; 146(1):163-75. Willingham MC, Haigler HT, Fitzgerald DJ, Gallo MG, Rutherford AV, Pastan IH. PMID: 6190668.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    50. Receptor-mediated endocytosis of epidermal growth factor. Methods Enzymol. 1983; 98:283-90. Haigler HT. PMID: 6321903.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    51. The influence of low temperature on the radiation sensitivity of enzymes. J Biol Chem. 1982 Nov 25; 257(22):13297-9. Kempner ES, Haigler HT. PMID: 7142147.
      View in: PubMed   Mentions: 22     Fields:    
    52. Binding, surface mobility, internalization, and degradation of rhodamine-labeled alpha 2-macroglobulin. Biochemistry. 1981 Sep 01; 20(18):5353-8. Maxfield FR, Willingham MC, Haigler HT, Dragsten P, Pastan IH. PMID: 6170323.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    53. Inhibitors of 125I-epidermal growth factor internalization. Biochem Biophys Res Commun. 1980 May 30; 94(2):630-7. Haigler HT, Willingham MC, Pastan I. PMID: 6967318.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    54. Production and characterization of antibody blocking epidermal growth factor:receptor interactions. Biochim Biophys Acta. 1980 May 23; 598(2):314-25. Haigler HT, Carpenter G. PMID: 6246948.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    55. Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells. J Biol Chem. 1980 Feb 25; 255(4):1239-41. Haigler HT, Maxfield FR, Willingham MC, Pastan I. PMID: 6243633.
      View in: PubMed   Mentions: 152     Fields:    Translation:AnimalsCells
    56. Hormone receptor topology and dynamics: morphological analysis using ferritin-labeled epidermal growth factor. Proc Natl Acad Sci U S A. 1979 Nov; 76(11):5689-93. McKanna JA, Haigler HT, Cohen S. PMID: 230489.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    57. Rapid stimulation of pinocytosis in human carcinoma cells A-431 by epidermal growth factor. J Cell Biol. 1979 Oct; 83(1):82-90. Haigler HT, McKanna JA, Cohen S. PMID: 315944.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimals
    58. Direct visualization of the binding and internalization of a ferritin conjugate of epidermal growth factor in human carcinoma cells A-431. J Cell Biol. 1979 May; 81(2):382-95. Haigler HT, McKanna JA, Cohen S. PMID: 313931.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansCells
    59. Visualization by fluorescence of the binding and internalization of epidermal growth factor in human carcinoma cells A-431. Proc Natl Acad Sci U S A. 1978 Jul; 75(7):3317-21. Haigler H, Ash JF, Singer SJ, Cohen S. PMID: 356052.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansCells
    60. Carnitine synthesis in rat tissue slices. Biochem Biophys Res Commun. 1974 Feb 04; 56(3):676-81. Haigler HT, Broquist HP. PMID: 4826875.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
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