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Comparison of Pharmacological Properties between the Kappa Opioid Receptor Agonist Nalfurafine and 42B, Its 3-Dehydroxy Analogue: Disconnect between in Vitro Agonist Bias and in Vivo Pharmacological Effects. ACS Chem Neurosci. 2020 10 07; 11(19):3036-3050.
Cao D, Huang P, Chiu YT, Chen C, Wang H, Li M, Zheng Y, Ehlert FJ, Zhang Y, Liu-Chen LY. PMID: 32897695; PMCID: PMC8336721.
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PubMed Mentions:
13 Fields:
Translation:
Animals
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Quantitating Ligand Bias Using the Competitive Model of Ligand Activity. Methods Mol Biol. 2019; 1957:235-247.
Stahl EL, Ehlert FJ, Bohn LM. PMID: 30919358.
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PubMed Mentions:
3 Fields:
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Analysis of Biased Agonism. Prog Mol Biol Transl Sci. 2018; 160:63-104.
Ehlert FJ. PMID: 30470293.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimals
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PDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β2-Adrenergic Receptors and Adenylyl Cyclase 6. Am J Respir Cell Mol Biol. 2018 04; 58(4):530-541.
Johnstone TB, Smith KH, Koziol-White CJ, Li F, Kazarian AG, Corpuz ML, Shumyatcher M, Ehlert FJ, Himes BE, Panettieri RA, Ostrom RS. PMID: 29262264; PMCID: PMC5894499.
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PubMed Mentions:
23 Fields:
Translation:
HumansCells
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Estimation of the receptor-state affinity constants of ligands in functional studies using wild type and constitutively active mutant receptors: Implications for estimation of agonist bias. J Pharmacol Toxicol Methods. 2017 Jan - Feb; 83:94-106.
Ehlert FJ, Stein RS. PMID: 27725245; PMCID: PMC5769967.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Cooperativity Has Empirical and Ultimate Levels of Explanation. Trends Pharmacol Sci. 2016 08; 37(8):620-623.
Ehlert FJ. PMID: 27364140.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Functional studies cast light on receptor states. Trends Pharmacol Sci. 2015 Sep; 36(9):596-604.
Ehlert FJ. PMID: 26123416; PMCID: PMC4562878.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Intrinsic relative activities of κ opioid agonists in activating Gα proteins and internalizing receptor: Differences between human and mouse receptors. Eur J Pharmacol. 2015 Aug 15; 761:235-44.
DiMattio KM, Ehlert FJ, Liu-Chen LY. PMID: 26057692; PMCID: PMC4532598.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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A novel method for analyzing extremely biased agonism at G protein-coupled receptors. Mol Pharmacol. 2015 May; 87(5):866-77.
Stahl EL, Zhou L, Ehlert FJ, Bohn LM. PMID: 25680753; PMCID: PMC4407734.
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PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
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A kinetic model of GPCRs: analysis of G protein activity, occupancy, coupling and receptor-state affinity constants. J Recept Signal Transduct Res. 2015; 35(4):269-83.
Stein RS, Ehlert FJ. PMID: 25353707.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands. Pharmacol Rev. 2014 Oct; 66(4):918-47.
Christopoulos A, Changeux JP, Catterall WA, Fabbro D, Burris TP, Cidlowski JA, Olsen RW, Peters JA, Neubig RR, Pin JP, Sexton PM, Kenakin TP, Ehlert FJ, Spedding M, Langmead CJ. PMID: 25026896; PMCID: PMC11060431.
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PubMed Mentions:
68 Fields:
Translation:
HumansCells
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Estimation of ligand affinity constants for receptor states in functional studies involving the allosteric modulation of G protein-coupled receptors: implications for ligand bias. J Pharmacol Toxicol Methods. 2014 May-Jun; 69(3):253-79.
Ehlert FJ, Griffin MT. PMID: 24434717; PMCID: PMC4028174.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Effects of asparagine mutagenesis of conserved aspartic acids in helix 2 (D2.50) and 3 (D3.32) of M1-M4 muscarinic receptors on the irreversible binding of nitrogen mustard analogs of acetylcholine and McN-A-343. Biochemistry. 2013 Jul 23; 52(29):4914-28.
Suga H, Ehlert FJ. PMID: 23826889; PMCID: PMC3855626.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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What ligand-gated ion channels can tell us about the allosteric regulation of G protein-coupled receptors. Prog Mol Biol Transl Sci. 2013; 115:291-347.
Ehlert FJ. PMID: 23415097.
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PubMed Mentions:
1 Fields:
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HumansAnimalsCells
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Muscarinic agonists and antagonists: effects on gastrointestinal function. Handb Exp Pharmacol. 2012; (208):343-74.
Ehlert FJ, Pak KJ, Griffin MT. PMID: 22222706.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Quantifying agonist activity at G protein-coupled receptors. J Vis Exp. 2011 Dec 26; (58):e3179.
Ehlert FJ, Suga H, Griffin MT. PMID: 22231636; PMCID: PMC3369663.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Characterization of muscarinic receptors in the human bladder mucosa: direct quantification of subtypes using 4-DAMP mustard. Urology. 2011 Sep; 78(3):721.e7-721.e12.
Yoshida A, Seki M, Nasrin S, Otsuka A, Ozono S, Takeda M, Masuyama K, Araki I, Ehlert FJ, Yamada S. PMID: 21777958.
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PubMed Mentions: Fields:
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HumansCells
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Analysis of agonism and inverse agonism in functional assays with constitutive activity: estimation of orthosteric ligand affinity constants for active and inactive receptor states. J Pharmacol Exp Ther. 2011 Aug; 338(2):671-86.
Ehlert FJ, Suga H, Griffin MT. PMID: 21576379; PMCID: PMC3141894.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Analysis of functional responses at G protein-coupled receptors: estimation of relative affinity constants for the inactive receptor state. J Pharmacol Exp Ther. 2011 Aug; 338(2):658-70.
Ehlert FJ, Griffin MT, Suga H. PMID: 21576380; PMCID: PMC3141892.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Mutagenesis of nucleophilic residues near the orthosteric binding pocket of M1 and M2 muscarinic receptors: effect on the binding of nitrogen mustard analogs of acetylcholine and McN-A-343. Mol Pharmacol. 2010 Oct; 78(4):745-55.
Suga H, Sawyer GW, Ehlert FJ. PMID: 20643905; PMCID: PMC2981396.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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The M2-muscarinic receptor inhibits the development of streptozotocin-induced neuropathy in mouse urinary bladder. J Pharmacol Exp Ther. 2010 Oct; 335(1):239-48.
Pak KJ, Ostrom RS, Matsui M, Ehlert FJ. PMID: 20624991; PMCID: PMC2957779.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Investigating the interaction of McN-A-343 with the M muscarinic receptor using its nitrogen mustard derivative and ACh mustard. Br J Pharmacol. 2010 Jul; 160(6):1534-49.
Figueroa KW, Suga H, Ehlert FJ. PMID: 20590642; PMCID: PMC2938823.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Impaired M3 and enhanced M2 muscarinic receptor contractile function in a streptozotocin model of mouse diabetic urinary bladder. Naunyn Schmiedebergs Arch Pharmacol. 2010 May; 381(5):441-54.
Pak KJ, Ostrom RS, Matsui M, Ehlert FJ. PMID: 20349044; PMCID: PMC2862252.
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PubMed Mentions:
10 Fields:
Translation:
Animals
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Investigating the interaction of McN-A-343 with the M2 muscarinic receptor using its nitrogen mustard derivative. Biochem Pharmacol. 2010 Apr 01; 79(7):1025-35.
Suga H, Ehlert FJ. PMID: 19913516; PMCID: PMC2815195.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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A conserved motif in the membrane proximal C-terminal tail of human muscarinic m1 acetylcholine receptors affects plasma membrane expression. J Pharmacol Exp Ther. 2010 Jan; 332(1):76-86.
Sawyer GW, Ehlert FJ, Shults CA. PMID: 19841475; PMCID: PMC2802481.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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The guinea pig ileum lacks the direct, high-potency, M(2)-muscarinic, contractile mechanism characteristic of the mouse ileum. Naunyn Schmiedebergs Arch Pharmacol. 2009 Oct; 380(4):327-35.
Griffin MT, Matsui M, Ostrom RS, Ehlert FJ. PMID: 19582435; PMCID: PMC2749929.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Estimation of relative microscopic affinity constants of agonists for the active state of the receptor in functional studies on M2 and M3 muscarinic receptors. Mol Pharmacol. 2009 Feb; 75(2):381-96.
Tran JA, Chang A, Matsui M, Ehlert FJ. PMID: 18996972; PMCID: PMC2684900.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Selectivity of agonists for the active state of M1 to M4 muscarinic receptor subtypes. J Pharmacol Exp Ther. 2009 Jan; 328(1):331-42.
Figueroa KW, Griffin MT, Ehlert FJ. PMID: 18824613; PMCID: PMC2644050.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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Use of acetylcholine mustard to study allosteric interactions at the M(2) muscarinic receptor. J Pharmacol Exp Ther. 2008 Nov; 327(2):518-28.
Suga H, Figueroa KW, Ehlert FJ. PMID: 18682569; PMCID: PMC2677819.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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5th International Symposium on receptor mechanisms, signal transduction and drug effects. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jun; 377(4-6):267-8.
Yamada S, Ehlert FJ, Hollenberg MD. PMID: 18357439.
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PubMed Mentions: Fields:
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HumansCells
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Two-state models and the analysis of the allosteric effect of gallamine at the M2 muscarinic receptor. J Pharmacol Exp Ther. 2008 Jun; 325(3):1039-60.
Ehlert FJ, Griffin MT. PMID: 18305010.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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On the analysis of ligand-directed signaling at G protein-coupled receptors. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jun; 377(4-6):549-77.
Ehlert FJ. PMID: 18253722.
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PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
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Cysteine pairs in the third intracellular loop of the muscarinic m1 acetylcholine receptor play a role in agonist-induced internalization. J Pharmacol Exp Ther. 2008 Jan; 324(1):196-205.
Sawyer GW, Ehlert FJ, Shults CA. PMID: 17540859.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Neuronally released acetylcholine acts on the M2 muscarinic receptor to oppose the relaxant effect of isoproterenol on cholinergic contractions in mouse urinary bladder. J Pharmacol Exp Ther. 2007 Aug; 322(2):631-7.
Ehlert FJ, Ahn S, Pak KJ, Park GJ, Sangnil MS, Tran JA, Matsui M. PMID: 17473176.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Estimation of agonist activity at G protein-coupled receptors: analysis of M2 muscarinic receptor signaling through Gi/o,Gs, and G15. J Pharmacol Exp Ther. 2007 Jun; 321(3):1193-207.
Griffin MT, Figueroa KW, Liller S, Ehlert FJ. PMID: 17392404.
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PubMed Mentions:
57 Fields:
Translation:
HumansAnimalsCells
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Differential coupling of muscarinic M1, M2, and M3 receptors to phosphoinositide hydrolysis in urinary bladder and longitudinal muscle of the ileum of the mouse. J Pharmacol Exp Ther. 2006 Aug; 318(2):649-56.
Tran JA, Matsui M, Ehlert FJ. PMID: 16675640.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Determination of the rate of muscarinic M1 receptor plasma membrane delivery using a regulated secretion/aggregation system. J Pharmacol Toxicol Methods. 2006 May-Jun; 53(3):219-33.
Sawyer GW, Ehlert FJ, Hart JP. PMID: 16213169.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Analysis of allosterism in functional assays. J Pharmacol Exp Ther. 2005 Nov; 315(2):740-54.
Ehlert FJ. PMID: 16046613.
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PubMed Mentions:
46 Fields:
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The M2 muscarinic receptor mediates contraction through indirect mechanisms in mouse urinary bladder. J Pharmacol Exp Ther. 2005 Apr; 313(1):368-78.
Ehlert FJ, Griffin MT, Abe DM, Vo TH, Taketo MM, Manabe T, Matsui M. PMID: 15608083.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Functional analysis of muscarinic acetylcholine receptors using knockout mice. Life Sci. 2004 Nov 05; 75(25):2971-81.
Matsui M, Yamada S, Oki T, Manabe T, Taketo MM, Ehlert FJ. PMID: 15474550.
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PubMed Mentions:
25 Fields:
Translation:
Animals
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Comparison of the antimuscarinic action of p-fluorohexahydrosiladifenidol in ileal and tracheal smooth muscle. J Pharmacol Exp Ther. 2005 Feb; 312(2):592-600.
Ehlert FJ, Hsu JC, Leung K, Lee AG, Shehnaz D, Griffin MT. PMID: 15456838.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Contractile role of M2 and M3 muscarinic receptors in gastrointestinal, airway and urinary bladder smooth muscle. Life Sci. 2003 Dec 05; 74(2-3):355-66.
Ehlert FJ. PMID: 14607264.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
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Muscarinic agonist-mediated heterologous desensitization in isolated ileum requires activation of both muscarinic M2 and M3 receptors. J Pharmacol Exp Ther. 2004 Jan; 308(1):339-49.
Griffin MT, Matsui M, Shehnaz D, Ansari KZ, Taketo MM, Manabe T, Ehlert FJ. PMID: 14563784.
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PubMed Mentions:
7 Fields:
Translation:
Animals
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[Case report: Porcine circovirus type 2 infection in an European wild boar (Sus scrofa) in the state of Brandenburg, Germany]. Dtsch Tierarztl Wochenschr. 2003 Oct; 110(10):426-8.
Schulze C, Neumann G, Grütze I, Engelhardt A, Mirle C, Ehlert F, Hlinak A. PMID: 14650740.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Comparison of the pharmacological antagonism of M2 and M3 muscarinic receptors expressed in isolation and in combination. Biochem Pharmacol. 2003 Apr 15; 65(8):1227-41.
Griffin MT, Hsu JC, Shehnaz D, Ehlert FJ. PMID: 12694864.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Increased relaxant action of forskolin and isoproterenol against muscarinic agonist-induced contractions in smooth muscle from M2 receptor knockout mice. J Pharmacol Exp Ther. 2003 Apr; 305(1):106-13.
Matsui M, Griffin MT, Shehnaz D, Taketo MM, Ehlert FJ. PMID: 12649358.
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PubMed Mentions:
19 Fields:
Translation:
Animals
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Pharmacological analysis of the contractile role of M2 and M3 muscarinic receptors in smooth muscle. Recept Channels. 2003; 9(4):261-77.
Ehlert FJ. PMID: 12893538.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor. J Biol Chem. 2002 May 31; 277(22):19276-80.
Lin DC, Bullock CM, Ehlert FJ, Chen JL, Tian H, Zhou QY. PMID: 11886876.
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PubMed Mentions:
107 Fields:
Translation:
HumansAnimalsCells
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Acetylcholine-induced desensitization of muscarinic contractile response in Guinea pig ileum is inhibited by pertussis toxin treatment. J Pharmacol Exp Ther. 2001 Dec; 299(3):1126-32.
Ehlert FJ, Ansari KZ, Shehnaz D, Sawyer GW, Griffin MT. PMID: 11714903.
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PubMed Mentions: Fields:
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AnimalsCells
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Acetylcholine-induced desensitization of the contractile response to histamine in Guinea pig ileum is prevented by either pertussis toxin treatment or by selective inactivation of muscarinic M(3) receptors. J Pharmacol Exp Ther. 2001 Jun; 297(3):1152-9.
Shehnaz D, Ansari KZ, Ehlert FJ. PMID: 11356941.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle. Mol Pharmacol. 2001 Apr; 59(4):692-8.
Li M, Bullock CM, Knauer DJ, Ehlert FJ, Zhou QY. PMID: 11259612.
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PubMed Mentions:
112 Fields:
Translation:
HumansAnimalsCells
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Human urotensin II mediates vasoconstriction via an increase in inositol phosphates. Eur J Pharmacol. 2000 Oct 13; 406(2):265-71.
Saetrum Opgaard O, Nothacker H, Ehlert FJ, Krause DN. PMID: 11020490.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Functional role of muscarinic M(2) receptors in alpha,beta-methylene ATP induced, neurogenic contractions in guinea-pig ileum. Br J Pharmacol. 2000 Apr; 129(7):1458-64.
Sawyer GW, Lambrecht G, Ehlert FJ. PMID: 10742302; PMCID: PMC1571964.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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The delta-opioid receptor: molecular pharmacology, signal transduction, and the determination of drug efficacy. Pharmacol Rev. 1999 Sep; 51(3):503-32.
Quock RM, Burkey TH, Varga E, Hosohata Y, Hosohata K, Cowell SM, Slate CA, Ehlert FJ, Roeske WR, Yamamura HI. PMID: 10471416.
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PubMed Mentions:
44 Fields:
Translation:
HumansAnimalsCells
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A simple method for estimation of agonist activity at receptor subtypes: comparison of native and cloned M3 muscarinic receptors in guinea pig ileum and transfected cells. J Pharmacol Exp Ther. 1999 May; 289(2):981-92.
Ehlert FJ, Griffin MT, Sawyer GW, Bailon R. PMID: 10215678.
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PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
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Muscarinic M3 receptor inactivation reveals a pertussis toxin-sensitive contractile response in the guinea pig colon: evidence for M2/M3 receptor interactions. J Pharmacol Exp Ther. 1999 Apr; 289(1):464-76.
Sawyer GW, Ehlert FJ. PMID: 10087039.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Comparison of functional antagonism between isoproterenol and M2 muscarinic receptors in guinea pig ileum and trachea. J Pharmacol Exp Ther. 1999 Mar; 288(3):969-76.
Ostrom RS, Ehlert FJ. PMID: 10027833.
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PubMed Mentions:
7 Fields:
Translation:
Animals
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Pertussis toxin increases isoproterenol induced relaxation in field-stimulated ileum. Eur J Pharmacol. 1999 Feb 12; 367(1):81-4.
Sawyer G, Ehlert F. PMID: 10082268.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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Contractile role of M2 and M3 muscarinic receptors in gastrointestinal smooth muscle. Life Sci. 1999; 64(6-7):387-94.
Ehlert FJ, Sawyer GW, Esqueda EE. PMID: 10069501.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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Characterization of the "silent" 5-HT1B receptors of rabbit iliac artery. Ann N Y Acad Sci. 1998 Dec 15; 861:259.
Yildiz O, Ehlert F, Purdy RE. PMID: 9928277.
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PubMed Mentions: Fields:
Translation:
Animals
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M2 muscarinic receptors inhibit forskolin- but not isoproterenol-mediated relaxation in bovine tracheal smooth muscle. J Pharmacol Exp Ther. 1998 Jul; 286(1):234-42.
Ostrom RS, Ehlert FJ. PMID: 9655865.
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PubMed Mentions:
8 Fields:
Translation:
Animals
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The use of irreversible ligands to inactivate receptor subtypes: 4-DAMP mustard and muscarinic receptors in smooth muscle. Life Sci. 1998; 62(17-18):1659-64.
Ehlert FJ, Griffin MT. PMID: 9585153.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Contractile roles of the M2 and M3 muscarinic receptors in the guinea pig colon. J Pharmacol Exp Ther. 1998 Jan; 284(1):269-77.
Sawyer GW, Ehlert FJ. PMID: 9435187.
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PubMed Mentions:
14 Fields:
Translation:
Animals
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The efficacy of delta-opioid receptor-selective drugs. Life Sci. 1998; 62(17-18):1531-6.
Burkey TH, Ehlert FJ, Hosohata Y, Quock RM, Cowell S, Hosohata K, Varga E, Stropova D, Li X, Slate C, Nagase H, Porreca F, Hruby VJ, Roeske WR, Yamamura HI. PMID: 9585131.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Relative efficacies of cannabinoid CB1 receptor agonists in the mouse brain. Eur J Pharmacol. 1997 Oct 08; 336(2-3):295-8.
Burkey TH, Quock RM, Consroe P, Ehlert FJ, Hosohata Y, Roeske WR, Yamamura HI. PMID: 9384246.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Subtypes of the muscarinic receptor in smooth muscle. Life Sci. 1997; 61(18):1729-40.
Ehlert FJ, Ostrom RS, Sawyer GW. PMID: 9365220.
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PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
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M2 muscarinic receptor inhibition of agonist-induced cyclic adenosine monophosphate accumulation and relaxation in the guinea pig ileum. J Pharmacol Exp Ther. 1997 Jan; 280(1):189-99.
Ostrom RS, Ehlert FJ. PMID: 8996196.
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PubMed Mentions:
6 Fields:
Translation:
Animals
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The interaction of the enantiomers of aceclidine with subtypes of the muscarinic receptor. J Pharmacol Exp Ther. 1996 Dec; 279(3):1335-44.
Ehlert FJ, Griffin MT, Glidden PF. PMID: 8968358.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Plasticity of contractile endothelin-B receptors in human arteries after organ culture. Br J Pharmacol. 1996 Nov; 119(6):1159-66.
Adner M, Cantera L, Ehlert F, Nilsson L, Edvinsson L. PMID: 8937719; PMCID: PMC1915908.
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PubMed Mentions:
16 Fields:
Translation:
Humans
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Stimulation of cyclic AMP accumulation and phosphoinositide hydrolysis by M3 muscarinic receptors in the rat peripheral lung. Biochem Pharmacol. 1996 Aug 23; 52(4):643-58.
Esqueda EE, Gerstin EH, Griffin MT, Ehlert FJ. PMID: 8759038.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Involvement of the M2 muscarinic receptor in contractions of the guinea pig trachea, guinea pig esophagus, and rat fundus. Biochem Pharmacol. 1996 Mar 22; 51(6):779-88.
Thomas EA, Ehlert FJ. PMID: 8602873.
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PubMed Mentions:
6 Fields:
Translation:
Animals
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The quaternary transformation products of N-(3-chloropropyl)-4-piperidinyl diphenylacetate and N-(2-chloroethyl)-4-piperidinyl diphenylacetate (4-DAMP mustard) have differential affinity for subtypes of the muscarinic receptor. J Pharmacol Exp Ther. 1996 Feb; 276(2):405-10.
Ehlert FJ, Oliff HS, Griffin MT. PMID: 8632303.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Inhibition of muscarinic stimulated phosphoinositide hydrolysis in the rat parotid gland by cAMP. Life Sci. 1996; 58(2):145-53.
Gerstin EH, Ehlert FJ. PMID: 8606623.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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The interaction of 4-DAMP mustard with subtypes of the muscarinic receptor. Life Sci. 1996; 58(22):1971-8.
Ehlert FJ. PMID: 8637426.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Cell cycle regulation of cdc25C transcription is mediated by the periodic repression of the glutamine-rich activators NF-Y and Sp1. Nucleic Acids Res. 1995 Oct 11; 23(19):3822-30.
Zwicker J, Gross C, Lucibello FC, Truss M, Ehlert F, Engeland K, Müller R. PMID: 7479023; PMCID: PMC307297.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Functional role of M2 muscarinic receptors in the guinea pig ileum. Life Sci. 1995; 56(11-12):965-71.
Ehlert FJ, Thomas EA. PMID: 10188800.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Pertussis toxin blocks M2 muscarinic receptor-mediated effects on contraction and cyclic AMP in the guinea pig ileum, but not M3-mediated contractions and phosphoinositide hydrolysis. J Pharmacol Exp Ther. 1994 Nov; 271(2):1042-50.
Thomas EA, Ehlert FJ. PMID: 7965766.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Muscarinic receptors and novel strategies for the treatment of age-related brain disorders. Life Sci. 1994; 55(25-26):2135-45.
Ehlert FJ, Roeske WR, Yamamura HI. PMID: 7997072.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Kinetics of activation and in vivo muscarinic receptor binding of N-(2-bromoethyl)-4-piperidinyl diphenylacetate: an analog of 4-DAMP mustard. J Pharmacol Exp Ther. 1993 Jul; 266(1):301-5.
Griffin MT, Thomas EA, Ehlert FJ. PMID: 8331565.
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1 Fields:
Translation:
Animals
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Functional role for the M2 muscarinic receptor in smooth muscle of guinea pig ileum. Mol Pharmacol. 1993 Jul; 44(1):102-10.
Thomas EA, Baker SA, Ehlert FJ. PMID: 8393516.
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PubMed Mentions:
22 Fields:
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AnimalsCells
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Heparin, dextran and trypan blue allosterically modulate M2 muscarinic receptor binding properties and interfere with receptor-mediated inhibition of adenylate cyclase. J Pharmacol Exp Ther. 1992 Dec; 263(3):910-7.
Gerstin EH, Luong T, Ehlert FJ. PMID: 1281880.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Specific inhibition of isoproterenol-stimulated cyclic AMP accumulation by M2 muscarinic receptors in rat intestinal smooth muscle. J Pharmacol Exp Ther. 1992 Oct; 263(1):221-5.
Griffin MT, Ehlert FJ. PMID: 1328607.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Conversion of N-(2-chloroethyl)-4-piperidinyl diphenylacetate (4-DAMP mustard) to an aziridinium ion and its interaction with muscarinic receptors in various tissues. Mol Pharmacol. 1992 Apr; 41(4):718-26.
Thomas EA, Hsu HH, Griffin MT, Hunter AL, Luong T, Ehlert FJ. PMID: 1569923.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Allosterism and drug action. Proc West Pharmacol Soc. 1992; 35:215-9.
Ehlert FJ. PMID: 1502228.
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1 Fields:
Translation:
HumansAnimalsCells
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Irreversible effects of 4-DAMP mustard on muscarinic receptors in vivo. Proc West Pharmacol Soc. 1992; 35:233-7.
Thomas EA, Ehlert FJ. PMID: 1502231.
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Animals
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Multiple interdependent regulatory sites in the mouse c-fos promoter determine basal level transcription: cell type-specific effects. Nucleic Acids Res. 1991 Jul 11; 19(13):3583-91.
Lucibello FC, Ehlert F, Müller R. PMID: 1906603; PMCID: PMC328383.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Heterogeneity of muscarinic receptor subtypes in cerebral blood vessels. J Pharmacol Exp Ther. 1991 Jul 01; 258(1):304-10.
Garcia-Villalon AL, Krause DN, Ehlert FJ, Duckles SP. PMID: 1649298.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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N-[3H]methylscopolamine labeling of non-M1, non-M2 muscarinic receptor binding sites in rat brain. J Pharmacol Exp Ther. 1991 Mar; 256(3):1173-81.
Smith TD, Annis SJ, Ehlert FJ, Leslie FM. PMID: 2005579.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Differential coupling of subtypes of the muscarinic receptor to signaling mechanisms in brain and peripheral tissues. Adv Exp Med Biol. 1991; 287:301-12.
Ehlert FJ, Delen FM, Yun SH, Tran P. PMID: 1759614.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Regional distribution of M1, M2 and non-M1, non-M2 subtypes of muscarinic binding sites in rat brain. J Pharmacol Exp Ther. 1990 Dec; 255(3):1148-57.
Ehlert FJ, Tran LP. PMID: 2262898.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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Differential coupling of subtypes of the muscarinic receptor to adenylate cyclase and phosphoinositide hydrolysis in the longitudinal muscle of the rat ileum. Mol Pharmacol. 1990 Nov; 38(5):689-97.
Candell LM, Yun SH, Tran LL, Ehlert FJ. PMID: 2172776.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Signaling through the muscarinic receptor-adenylate cyclase system of the heart is buffered against GTP over a range of concentrations. Mol Pharmacol. 1990 Jul; 38(1):148-58.
Ehlert FJ, Rathbun BE. PMID: 2370853.
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PubMed Mentions:
9 Fields:
Translation:
Animals
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Influence of pH on the binding of scopolamine and N-methylscopolamine to muscarinic receptors in the corpus striatum and heart of rats. Mol Pharmacol. 1990 Jul; 38(1):143-7.
Ehlert FJ, Delen FM. PMID: 2370852.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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The interaction of amitriptyline, doxepin, imipramine and their N-methyl quaternary ammonium derivatives with subtypes of muscarinic receptors in brain and heart. J Pharmacol Exp Ther. 1990 Apr; 253(1):13-9.
Ehlert FJ, Delen FM, Yun SH, Liem HA. PMID: 2329499.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Tertiary 2-haloethylamine derivatives of the muscarinic agent McN-A-343, [4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]trimethylammonium chloride. J Med Chem. 1990 Jan; 33(1):281-6.
Ringdahl B, Mellin C, Ehlert FJ, Roch M, Rice KM, Jenden DJ. PMID: 2296024.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Muscarinic M1 receptors stimulate phosphoinositide hydrolysis in bovine cerebral arteries. Life Sci. 1990; 47(23):2163-9.
Garcia-Villalon AL, Ehlert FJ, Krause DN, Duckles SP. PMID: 2176261.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Coupling of subtypes of the muscarinic receptor to adenylate cyclase in the corpus striatum and heart. J Pharmacol Exp Ther. 1989 Nov; 251(2):660-71.
Ehlert FJ, Delen FM, Yun SH, Friedman DJ, Self DW. PMID: 2810116.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Gallamine allosterically antagonizes muscarinic receptor-mediated inhibition of adenylate cyclase activity in the rat myocardium. J Pharmacol Exp Ther. 1988 Nov; 247(2):596-602.
Ehlert FJ. PMID: 3183955.
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PubMed Mentions:
9 Fields:
Translation:
Animals
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Means of clarifying mechanisms of desensitization. Energetics of conformational changes in receptors. Trends Pharmacol Sci. 1988 Nov; 9(11):393-4.
Ehlert FJ. PMID: 3270959.
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Cells
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Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods. Mol Pharmacol. 1988 Feb; 33(2):187-94.
Ehlert FJ. PMID: 2828914.
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PubMed Mentions:
84 Fields:
Translation:
HumansAnimalsCells
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Correlation between the binding parameters of muscarinic agonists and their inhibition of adenylate cyclase activity. Adv Exp Med Biol. 1988; 236:265-76.
Ehlert FJ. PMID: 3071111.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Effects of an alkylating derivative of oxotremorine (BM 123A) on heart rate, muscarinic receptors and adenylate cyclase activity in the rabbit myocardium. J Pharmacol Exp Ther. 1987 Jun; 241(3):804-11.
Ehlert FJ. PMID: 3598904.
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Translation:
Animals
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Coupling of muscarinic receptors to adenylate cyclase in the rabbit myocardium: effects of receptor inactivation. J Pharmacol Exp Ther. 1987 Jan; 240(1):23-30.
Ehlert FJ. PMID: 3806386.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Relation between behaviorally augmented tolerance and upregulation of muscarinic receptors in the CNS: effects of chronic administration of chronic administration of scopolamine. Psychopharmacology (Berl). 1986; 88(1):33-9.
Russell RW, Ehlert FJ, Hwa JJ. PMID: 3080776.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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The relationship between muscarinic receptor occupancy and adenylate cyclase inhibition in the rabbit myocardium. Mol Pharmacol. 1985 Nov; 28(5):410-21.
Ehlert FJ. PMID: 4058422.
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PubMed Mentions:
41 Fields:
Translation:
Animals
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The binding of a 2-chloroethylamine derivative of oxotremorine (BM 123) to muscarinic receptors in the rat cerebral cortex. Mol Pharmacol. 1985 Aug; 28(2):107-19.
Ehlert FJ, Jenden DJ. PMID: 3839562.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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The conversion of 2-chloroalkylamine analogues of oxotremorine to aziridinium ions and their interactions with muscarinic receptors in the guinea pig ileum. Mol Pharmacol. 1984 Sep; 26(2):170-9.
Ringdahl B, Resul B, Ehlert FJ, Jenden DJ, Dahlbom R. PMID: 6332977.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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A comparison of the effects of cinnarizine and related compounds on [3H]nitrendipine binding in the brain, heart and ileum. Life Sci. 1984 Jun 11; 34(24):2347-55.
Ehlert FJ, Yamamura HI. PMID: 6328164.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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An alkylating derivative of oxotremorine interacts irreversibly with the muscarinic receptor. Life Sci. 1984 Mar 05; 34(10):985-91.
Ehlert FJ, Jenden DJ, Ringdahl B. PMID: 6700365.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Comparison of the muscarinic receptor binding activity of some tertiary amines and their quaternary ammonium analogues. Mol Pharmacol. 1984 Jan; 25(1):46-50.
Ehlert FJ, Jenden DJ. PMID: 6708935.
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AnimalsCells
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An allosteric model for benzodiazepine receptor function. Biochem Pharmacol. 1983 Aug 15; 32(16):2375-83.
Ehlert FJ, Roeske WR, Gee KW, Yamamura HI. PMID: 6311215.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimals
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Differential effect of gamma-aminobutyric acid on benzodiazepine receptor subtypes labeled by [3H]propyl beta-carboline-3-carboxylate in rat brain. J Pharmacol Exp Ther. 1983 Apr; 225(1):132-7.
Gee KW, Ehlert FJ, Yamamura HI. PMID: 6300371.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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The benzodiazepine receptor: complex binding properties and the influence of GABA. Adv Biochem Psychopharmacol. 1983; 36:209-20.
Ehlert FJ, Roeske WR, Yamamura SH, Yamamura HI. PMID: 6305148.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Recent advances in muscarinic receptor heterogeneity and regulation. Adv Biochem Psychopharmacol. 1983; 36:15-30.
Roeske WR, Ehlert FJ, Barritt DS, Yamanaka K, Rosenberger LB, Yamada S, Yamamura S, Yamamura HI. PMID: 6344563.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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A simple and rapid radio-receptor assay for the estimation of acetylcholine. Life Sci. 1982 Jul 26; 31(4):347-54.
Ehlert FJ, Roeske WR, Yamamura HI. PMID: 7144444.
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AnimalsCells
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The influence of temperature and gamma-aminobutyric acid on benzodiazepine receptor subtypes in the hippocampus of the rat. Biochem Biophys Res Commun. 1982 Jun 30; 106(4):1134-40.
Gee KW, Ehlert FJ, Yamamura HI. PMID: 6288041.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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The binding of [3H]nitrendipine to receptors for calcium channel antagonists in the heart, cerebral cortex, and ileum of rats. Life Sci. 1982 Jun 21; 30(25):2191-202.
Ehlert FJ, Roeske WR, Itoga E, Yamamura HI. PMID: 7109844.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Modulation of benzodiazepine receptor binding: insight into pharmacological efficacy. Eur J Pharmacol. 1982 Feb 26; 78(2):249-53.
Ehlert FJ, Ragan P, Chen A, Roeske WR, Yamamura HI. PMID: 6281035.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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The interaction of [3H]nitrendipine with receptors for calcium antagonists in the cerebral cortex and heart of rats. Biochem Biophys Res Commun. 1982 Feb 11; 104(3):937-43.
Ehlert FJ, Itoga E, Roeske WR, Yamamura HI. PMID: 7073736.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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A radioreceptor assay for estimation of acetylcholine. Proc West Pharmacol Soc. 1982; 25:237-9.
Ehlert FJ, Roeske WR, Yamamura HI. PMID: 7122497.
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Translation:
AnimalsCells
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Multiple benzodiazepine receptors and their regulation by gamma-aminobutyric acid. Life Sci. 1981 Jul 20; 29(3):235-48.
Ehlert FJ, Roeske WR, Yamamura HI. PMID: 6270491.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Striatal muscarinic receptors: regulation by dopaminergic agonists. Life Sci. 1981 May 21; 28(21):2441-8.
Ehlert FJ, Roeske WR, Yamamura HI. PMID: 7253832.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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Mathematical analysis of the kinetics of competitive inhibition in neurotransmitter receptor binding assays. Mol Pharmacol. 1981 May; 19(3):367-71.
Ehlert FJ, Roeske WR, Yamamura HI. PMID: 6267444.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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gamma-Aminobutyric acid regulation of the benzodiazepine receptor: biochemical evidence for pharmacologically different effects of benzodiazepines and propyl beta-carboline-3-carboxylate. Eur J Pharmacol. 1981 Apr 09; 70(4):593-5.
Ehlert FJ, Roeske WR, Braestrup C, Yamamura SH, Yamamura HI. PMID: 6113152.
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PubMed Mentions:
4 Fields:
Translation:
Cells
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Muscarinic receptor: regulation by guanine nucleotides, ions, and N-ethylmaleimide. Fed Proc. 1981 Feb; 40(2):153-9.
Ehlert FJ, Roeske WR, Yamamura HI. PMID: 7461140.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Age-related alterations in neurotransmitter receptors: an electrophysiological and biochemical analysis. Neurobiol Aging. 1981; 2(1):3-8.
Lippa AS, Critchett DJ, Ehlert F, Yamamura HI, Enna SJ, Bartus RT. PMID: 6115325.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Dopaminergic regulation of muscarinic receptor binding in the corpus striatum. Proc West Pharmacol Soc. 1981; 24:93-5.
Ehlert FJ, Roeske WR, Yamamura HI. PMID: 7255494.
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Translation:
Animals
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Differential regulation of muscarinic agonist binding sites following chronic cholinesterase inhibition. Eur J Pharmacol. 1980 Sep 05; 66(4):379-80.
Smit MH, Ehlert FJ, Yamamura S, Roeske WR, Yamamura HI. PMID: 7418725.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Failure of septal lesions to alter muscarinic cholinergic or benzodiazepine binding sites in hippocampus of rat brain. Brain Res. 1980 Aug 11; 195(1):203-7.
Overstreet DH, Speth RC, Hruska RE, Ehlert F, Dumont Y, Yamamura HI. PMID: 6105004.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Muscarinic receptor subsensitivity in the longitudinal muscle of the rat ileum following chronic anticholinesterase treatment with diisopropylfluorophosphate. Biochem Pharmacol. 1980 May 15; 29(10):1391-7.
Ehlert FJ, Kokka N, Fairhurst AS. PMID: 7396975.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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Muscarinic receptor binding in rat brain using the agonist, [3H]cis methyldioxolane. Life Sci. 1980 Mar 24; 26(12):961-7.
Ehlert FJ, Dumont Y, Roeske WR, Yamamura HI. PMID: 7392777.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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The influence of guanyl-5'-yl imidodiphosphate and sodium chloride on the binding of the muscarinic agonist, [3H] cis methyldioxolane. Eur J Pharmacol. 1980 Feb 08; 61(3):317-8.
Ehlert FJ, Yamamura HI, Triggle DJ, Roeske WR. PMID: 7363942.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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Differential supersensitivity of beta-receptor subtypes in rat cortex and cerebellum after central noradrenergic denervation. Life Sci. 1980 Feb 04; 26(5):355-64.
U'Prichard DC, Reisine TD, Yamamura S, Mason ST, Fibiger HC, Ehlert F, Yamamura HI. PMID: 6245317.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Interactions of D600 (methoxyverapamil) and local anesthetics with rat brain alpha-adrenergic and muscarinic receptors. Biochem Pharmacol. 1980 Feb; 29(2):155-62.
Fairhurst AS, Whittaker ML, Ehlert FJ. PMID: 6244833.
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PubMed Mentions:
14 Fields:
Translation:
Animals
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The influence of guanyl-5'-yl imidodiphosphate and sodium on muscarinic receptor binding in the rat brain and longitudinal muscle of the rat ileum. Life Sci. 1980 Jan 21; 26(3):245-52.
Ehlert FJ, Roeske WR, Rosenberger LB, Yamamura HI. PMID: 7360006.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Altered [3H]quinuclidinyl benzilate binding in the striatum of rats following chronic cholinesterase inhibition with diisopropylfluorophosphate. Mol Pharmacol. 1980 Jan; 17(1):24-30.
Ehlert FJ, Kokka N, Fairhurst AS. PMID: 7383017.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Regulation of muscarinic receptor binding by guanine nucleotides and N-ethylmaleimide. J Supramol Struct. 1980; 14(2):149-62.
Ehlert FJ, Roeske WR, Yamamura HI. PMID: 7230804.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Decrease in (3H)-quinuclidinyl bezilate binding to the muscarinic cholinergic receptor in the longitudinal muscle of the rat ileum following chronic administration of diisopropylfuorophosphate. Proc West Pharmacol Soc. 1977; 20:1-7.
Ehlert FJ, Kokka N. PMID: 896813.
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Translation:
AnimalsCells