Eric Tzy-shi Wang

Title(s)Professor, Neurology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(714) 456-6808
ORCID ORCID Icon0000-0003-2655-5525 Additional info
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    Collapse Overview 
    Collapse overview
    Repeat expansion diseases, RNA biology, therapeutic approaches to genetic disease

    Collapse Biography 
    Collapse education and training
    Harvard CollegeB.A.Biochemistry
    Harvard-MIT Division of Health Sciences and TechnologyPh.D.Medical Engineering/Medical Physics
    Collapse awards and honors
    International Myotonic Dystrophy Consortium2026Steinert Basic Sciences Award in Myotonic Dystrophy
    The University at Albany2025Inaugural Center of Excellence in RNA Research & Therapeutics (CERRT) SPARK Award
    University of Florida2025UF Innovator of the Year Award
    University of Florida2023UF College of Medicine Doctoral Dissertation Advisor/Mentoring Award
    University of Florida2023UF Research Foundation Professorship Award
    Chan-Zuckerberg Initiative2018  - 2023Chan-Zuckerberg Initiative Ben Barres Career Acceleration Award
    University of Florida2016Thomas H. Maren Junior Investigator Award
    NIH2013  - 2018NIH Early Independence Award

    Collapse Research 

    Collapse Bibliographic 
    Collapse publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tissue-specific CTG•CAG expansion rate and disease severity are modified by DNA repair genes expression levels in myotonic dystrophy type 1 patients. DNA Repair (Amst). 2026 Sep; 165:103950. Palma-Jiménez M, Ramirez-Carvajal L, Olafson H, Wang ET, Morales F. PMID: 42419013.
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    2. A new era for myotonic dystrophy: Improved delivery of a DMPK-targeted oligonucleotide modulates muscle transcriptomes and function. Mol Ther. 2026 Jul 01; 34(7):3729-3730. Wang ET. PMID: 42341747; PMCID: PMC13330047.
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    3. Muscleblind-like proteins dimerize by forming disulfide bonds to regulate alternative splicing and pathogenic RNA foci formation. Nucleic Acids Res. 2026 May 20; 54(10). Knudson LA, Kosti A, Hildebrandt RP, Jennings E, Zhou EX, Moss KR, Shi L, Nguyen GN, Janusz-Kaminska A, Wang ET, Bassell GJ. PMID: 42227335; PMCID: PMC13227107.
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    4. Enhanced antisense oligonucleotide delivery reveals that transcript turnover impacts apparent splicing rescue in myotonic dystrophy. Mol Ther. 2026 Aug 05; 34(8):4844-4855. Shea EN, Olafson HR, Muscato DR, Adams LM, Valero MC, McKee KK, Shen X, Dougherty PG, Hicks AN, Liu N, Kheirabadi M, Streeter M, Li X, Mon P, Girgenrath M, Sethuraman N, Qian Z, Wang ET. PMID: 42163456; PMCID: PMC13464307.
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    5. Myonuclear Domain-Associated and Central Nucleation-Dependent Spatial Restriction of Dystrophin Protein Expression. J Cachexia Sarcopenia Muscle. 2026 Apr; 17(2):e70284. Chwalenia K, Feng VY, Hemmer N, Hildyard JCW, Roskrow LE, Piercy RJ, Wang ET, Aartsma-Rus A, van Putten M, Wood MJA, Roberts TC. PMID: 41944729; PMCID: PMC13055465.
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    6. Muscleblind-like proteins dimerize by forming disulfide bonds to regulate alternative splicing and pathogenic RNA foci formation. bioRxiv. 2026 Mar 26. Knudson LA, Kosti A, Moss KR, Shi L, Nguyen GN, Janusz-Kaminska A, Zhou EX, Hildebrandt RP, Wang ET, Bassell GJ. PMID: 41929128; PMCID: PMC13041988.
      View in: PubMed   Mentions:
    7. Metformin improves RAN protein pathology, alternative splicing, and behavioral phenotypes in SCA8 mice. Life Sci Alliance. 2026 May; 9(5). Romano LE, Tsukagoshi S, Davey-Osuch EE, Ajredini R, Manasi K, Ortiz TV, Rijos E, Bourgon NJ, Ames SE, Garrett TJ, Cleary JD, Wang ET, Ranum LP. PMID: 41771688; PMCID: PMC12954051.
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    8. Analysis of muscle and blood RNA samples from patients with myotonic dystrophy type 1 reveals the presence of new mis-splicing biomarkers of disease severity. J Med Genet. 2026 Feb 20; 63(3):164-173. Palma-Jiménez M, Ramirez-Carvajal L, Corrales E, Olafson H, Wang ET, Morales F. PMID: 41161721.
      View in: PubMed   Mentions:
    9. Modified Polycyclic Compounds Rescue Mis-splicing in Myotonic Dystrophy Type 1 Disease Models. ACS Chem Biol. 2026 Mar 20; 21(3):502-518. Frias JA, Hicks SM, Mazdiyasni H, Mishra SK, Sarkar K, Yeboah C, LeFever NM, Scotti MM, Zeghal H, Brandt N, Vangaveti S, Chakma P, Wang T, Reid TS, McMichael O, Crumbaugh C, Provenzano M, Hale MA, Cleary JD, Johnson NE, Wang ET, Reddy K, Berglund JA. PMID: 41716008; PMCID: PMC13010256.
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    10. Interventionally targeting somatic CAG expansions can be a rapid disease-modifying therapeutic avenue: Preclinical evidence. bioRxiv. 2025 Apr 28. Gall-Duncan T, Ko SY, Quick IK, Khan M, Feng K, Kelley CP, Coleman A, Touze A, Tang S, Mehkary M, Yokoi K, Herrington CR, You J, Lambie SC, Prasolava TK, Panigrahi GB, Park J, Nakatani K, Byrne LM, Wang P, Schneekloth JS, Nakamori M, Frankland PW, Wang ET, Pearson CE. PMID: 40330856; PMCID: PMC12051495.
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    11. CASP8 intronic expansion identified by poly-glycine-arginine pathology increases Alzheimer's disease risk. Proc Natl Acad Sci U S A. 2025 Feb 18; 122(7):e2416885122. Nguyen L, Ajredini R, Guo S, Romano LEL, Tomas RF, Bell LR, Ranum PT, Zu T, Bañez Coronel M, Kelley CP, Redding-Ochoa J, Nizamis E, Melloni A, Connors TR, Gaona A, Thangaraju K, Pletnikova O, Clark HB, Davidson BL, Yachnis AT, Golde TE, Lou X, Wang ET, Renton AE, Goate A, Valdmanis PN, Prokop S, Troncoso JC, Hyman BT, Ranum LPW. PMID: 39937857; PMCID: PMC11848317.
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